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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Methyl (R)-(-)-3-hydroxybutyrate Manufacturer/High quality/Best price/In stock

Cas:3976-69-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Methyl R-3-Hydroxybutanoate with high purity

Cas:3976-69-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Sinoway Industrial Co., Ltd.

Assay: 98% up by GC; Stable supply with over 50Mt annually; Appearance:Colorless transparent liquid Storage:room temprature Package:25kg/drum Application:Intermediate of Dorzolamide Port:Beijing/Shanghai/Shenzhen/Hangzhou

Methyl (R)-(-)-3-hydroxybutyrate

Cas:3976-69-0

Min.Order:1 Kilogram

FOB Price: $100.0

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Methyl (R)-(-)-3-hydroxybutyrate

Cas:3976-69-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Methyl (R)-(-)-3-hydroxybutyrate

Cas:3976-69-0

Min.Order:1

Negotiable

Type:Other

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Methyl (R)-(-)-3-hydroxybutyrate

Cas:3976-69-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our advantage:Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scient

TIANFU-CHEM Methyl (R)-(-)-3-hydroxybutyrate

Cas:3976-69-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New product CAS 3976-69-0 with high quality products

Cas:3976-69-0

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Chemical Name Methyl (R)-(-)-3-hydroxybutyrate Synonyms (R)-(-)-methyl 3-hydroxybutyrate CAS No. 3976-69-0 EINECS No. 223-610-0

(R)-(-)-methyl 3-hydroxybutyrate

Cas:3976-69-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Methyl (R)-(-)-3-hydroxybutyrate

Cas:3976-69-0

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Methyl (R)-(-)-3-hydroxybutyrate 3976-69-0

Cas:3976-69-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Methyl (R)-(-)-3-hydroxybutyrate CAS:3976-69-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality o

Methyl (R)-(-)-3-hydroxybutyrate CAS:3976-69-0

Cas:3976-69-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Methyl (R)-(-)-3-hydroxybutyrate

Cas:3976-69-0

Min.Order:1 Kilogram

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Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Methyl (R)-(-)-3-hydroxybutyrate/ LIDE PHARMA- Factory supply / Best price

Cas:3976-69-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Methyl (R)-(-)-3-hydroxybutyrate

Cas:3976-69-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TIANFUCHEM--3976-69-0--High purity Methyl (R)-(-)-3-hydroxybutyrate factory price

Cas:3976-69-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(R)-(-)-3-Hydroxybutyric acid methyl ester

Cas:3976-69-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

METHYL (R)-(-)-3-HYDROXYBUTYRATE

Cas:3976-69-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Methyl (R)-(-)-3-hydroxybutyra

Cas:3976-69-0

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Methyl (R)-(-)-3-hydroxybutyrate

Cas:3976-69-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products Methyl (R)-(-)-3-hydroxybutyrate

Cas:3976-69-0

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Methyl (R)-(-)-3-hydroxybutyrate

Cas:3976-69-0

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Methyl R-3-Hydroxybutanoate

Cas:3976-69-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

3976-69-0Appearance:white powder Storage:keep cold Package:according to customers' requirements Application:Pharmaceutical intermediates 3976-69-0 Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or accordin

3976-69-0

Cas:3976-69-0

Min.Order:1 Gram

Negotiable

Type:Other

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HANGZHOU YUNUO CHEMICAL CO.,LTD

moderate price & quick delivery Appearance:clear colorless liquid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:Used as Pharmaceutical Inte

(R)-(-)-3-hydroxybutyrate

Cas:3976-69-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

Methyl (R)-(-)-3-hydroxybutyrate Basic information Product Name: Methyl (R)-(-)-3-hydroxybutyrate Synonyms: METHYL 3-HYDROXYBUTANOATE;Methyl-3-hydroxybutyrate;METHYL (R)-(-)-3-HYDROXYBUTYRATE;METHYL (R)-3-HYDROXYBUTYRATE;METHYL D-(R)-3-HYDROXY

Methyl (R)-(-)-3-hydroxybutyrate

Cas:3976-69-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

(R)-(-)-3-Hydroxybutyric acid methyl ester

Cas:3976-69-0

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

TIANFUCHEM--3976-69-0--High purity Methyl (R)-(-)-3-hydroxybutyrate factory price

Cas:3976-69-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

(R)-(-)-3-Hydroxybutyric acid methyl ester

Cas:3976-69-0

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Product name Methyl R-3-hydroxybutanoate Content ≥98% CAS NO. 3976-69-0 Package Structure Formula Appearance:Colorl

Methyl (R)-(-)-3-Hydroxybutyrate supplier

Cas:3976-69-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Synthetic route

(R)-3-hydroxybutyric acid
625-72-9

(R)-3-hydroxybutyric acid

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
In diethyl ether100%
In methanol; diethyl ether at -10℃;76%
acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

A

(S)-3-hydroxybutyric acid methyl ester
53562-86-0

(S)-3-hydroxybutyric acid methyl ester

B

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
With Ru2Cl4-(S)-(2,2'-bis(diphenylphosphino)-1,1'-binaphthyl)2*NEt3; hydrogen In methanol at 35℃; under 76000.1 Torr; for 48h; Title compound not separated from byproducts;A 100%
B n/a
With <((R)-(1,1'-binaphthyl-2,2'-diyl)bis(diphenylphosphine))RuCl2>2NEt3; hydrogen In methanol at 35℃; under 76000.1 Torr; for 48h; Title compound not separated from byproducts;A n/a
B 100%
With hydrogen; Ru(BICP)Br2 In methanol at 40 - 65℃; under 750.075 - 3750.38 Torr;A n/a
B 95%
acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
With cat; hydrogen In methanol; dichloromethane at 25℃; under 77572.2 Torr; for 48h;100%
With (R)-MeOBiphepRuBr2; hydrogen In methanol at 50℃; under 15200 Torr; for 48h;100%
With (S)-4,12-bis(diphenylphosphino)-<2.2>paracyclophane-Ru(II)bis(trifluoroacetate); hydrogen; tetra-(n-butyl)ammonium iodide In methanol; water at -5℃; under 2585.7 Torr; for 18h;100%
methanol
67-56-1

methanol

Ethyl (R)-3-hydroxybutanoate
24915-95-5

Ethyl (R)-3-hydroxybutanoate

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
scandium tris(trifluoromethanesulfonate) at 64℃; for 10h;98%
(EtO)3TiO(CH2)2OTi(OEt)3 autoclave, 1.) 160 deg C, 17 bar, 2 h; 2.) 115 deg C, 3.5 bar, 27 h;82%
tert-butyl acetoacetate
1694-31-1

tert-butyl acetoacetate

A

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

B

tert-butyl (R)-3-hydroxybutanoate
110171-06-7

tert-butyl (R)-3-hydroxybutanoate

Conditions
ConditionsYield
With hydrogenchloride; hydrogen; [RuCl2-((R)-binap)]*NEt3 In methanol at 40℃; under 2585.7 Torr; for 8h; Kinetics; effect of acid, other substrate;A 3%
B 97%
With hydrogenchloride; hydrogen; <(R)-(BINAP)RuCl2>2*NEt3 In methanol at 40℃; under 2585.7 Torr; for 8h;A 3%
B 97%
acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

A

(S)-3-hydroxybutyric acid methyl ester
53562-86-0

(S)-3-hydroxybutyric acid methyl ester

B

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

C

3,3-bismethoxybutyric acid methyl ester
29267-46-7

3,3-bismethoxybutyric acid methyl ester

Conditions
ConditionsYield
With hydrogen; {RuI((R)-2,2'-bis(diphenylphospino)-1,1'-binaphthyl)(p-cymene)}I In methanol at 30℃; under 76000 Torr; for 35h; Product distribution; other: catalysts, solvents, time, pressure, temperatures;A 97%
B n/a
C 3%
methanol
67-56-1

methanol

carbon monoxide
201230-82-2

carbon monoxide

(R)-propylene oxide
15448-47-2

(R)-propylene oxide

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
With 3-HYDROXYPYRIDINE; dicobalt octacarbonyl In tetrahydrofuran at 65℃; under 31028.9 Torr; for 9h;92%
(S)-3-Hydroxy-4-((R)-toluene-4-sulfinyl)-butyric acid methyl ester
142176-67-8

(S)-3-Hydroxy-4-((R)-toluene-4-sulfinyl)-butyric acid methyl ester

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
With nickel90%
methanol
67-56-1

methanol

PHB/PHV biopolymer

PHB/PHV biopolymer

A

methyl (3R)-3-hydroxypentanoate
42558-50-9, 56009-31-5, 60793-22-8, 133098-13-2

methyl (3R)-3-hydroxypentanoate

B

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
With sulfuric acid In 1,2-dichloro-ethane for 48h; Heating;A 62%
B 87%
Methyl (S)-4-(p-Chlorophenylthio)-3-hydroxybutanoate
114607-86-2

Methyl (S)-4-(p-Chlorophenylthio)-3-hydroxybutanoate

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
nickel80%
methanol
67-56-1

methanol

poly(3(R)-hydroxybutyric acid)

poly(3(R)-hydroxybutyric acid)

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
With sulfuric acid In dichloromethane for 48h; Heating;78%
(2R,3R)-3-Hydroxy-2-phenylsulfanyl-butyric acid methyl ester

(2R,3R)-3-Hydroxy-2-phenylsulfanyl-butyric acid methyl ester

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
With nickel In ethanol for 0.5h; Ambient temperature;75%
methanol
67-56-1

methanol

poly([R]-3-hydroxybutyrate)

poly([R]-3-hydroxybutyrate)

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
With sulfuric acid In 1,2-dichloro-ethane at 80℃; for 120h; Heating / reflux;73%
poly[(R)-3-hydroxy butyric acid]

poly[(R)-3-hydroxy butyric acid]

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
With sulfuric acid In methanol; 1,2-dichloro-ethane for 72h; depolymerization; Heating;71%
(R)-methyl 3-(dimethyl(phenyl)silyl)butanoate
166020-21-9

(R)-methyl 3-(dimethyl(phenyl)silyl)butanoate

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
With peracetic acid; palladium diacetate; mercury(II) diacetate In acetic acid for 2h; Ambient temperature;43%
3-Hydroxybutyric acid
300-85-6, 625-71-8

3-Hydroxybutyric acid

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
In diethyl ether
(S)-4-Benzenesulfonyl-3-hydroxy-butyric acid methyl ester

(S)-4-Benzenesulfonyl-3-hydroxy-butyric acid methyl ester

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
With Raney Ni W-4 Yield given;
(R)-3-(benzyloxy)butanoic acid methyl ester
116761-24-1

(R)-3-(benzyloxy)butanoic acid methyl ester

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In acetic acid Product distribution; Ambient temperature;
methanol
67-56-1

methanol

poly(R)-3-hydroxybutanoic acid (PHB)

poly(R)-3-hydroxybutanoic acid (PHB)

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
With sulfuric acid
methanol
67-56-1

methanol

poly-(R)-3-hydroxybuttersaeure

poly-(R)-3-hydroxybuttersaeure

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
With sulfuric acid 1.) 1,2-dichloroethane, reflux, 2 h; 2.) reflux, 48 h; Yield given. Multistep reaction;
methanol
67-56-1

methanol

Biopol (73percent (R)-3-hydroxybutanoic acid - 27percent (R)-3-hydroxyvaleric acid copolymer)

Biopol (73percent (R)-3-hydroxybutanoic acid - 27percent (R)-3-hydroxyvaleric acid copolymer)

A

methyl (3R)-3-hydroxypentanoate
42558-50-9, 56009-31-5, 60793-22-8, 133098-13-2

methyl (3R)-3-hydroxypentanoate

B

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
With sulfuric acid 1.) 1,2-dichloroethane, reflux, 1 h; 2.) 1,2-dichloroethane, reflux, 3 d; Yield given. Multistep reaction. Yields of byproduct given;
methanol
67-56-1

methanol

poly<(R)-3-hydroxybutanoic acid>

poly<(R)-3-hydroxybutanoic acid>

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
With sulfuric acid; toluene-4-sulfonic acid 1.) 1,2-dichloroethane, reflux, 34 h; 2.) 1,2-dichloroethane, reflux, 12 h; Yield given; Multistep reaction;
(+)-macrosphelide E
200335-76-8

(+)-macrosphelide E

A

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

B

methyl (E,4R,5S)-4,5-dihydroxy-2-hexenoate
63357-08-4

methyl (E,4R,5S)-4,5-dihydroxy-2-hexenoate

Conditions
ConditionsYield
Stage #1: (+)-macrosphelide E With potassium carbonate In methanol at 20℃;
Stage #2: diazomethane In diethyl ether at 20℃; for 2h; Further stages.;
methanol
67-56-1

methanol

(+)-macrosphelide E
200335-76-8

(+)-macrosphelide E

A

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

B

methyl (E,4R,5S)-4,5-dihydroxy-2-hexenoate
63357-08-4

methyl (E,4R,5S)-4,5-dihydroxy-2-hexenoate

Conditions
ConditionsYield
With sulfuric acid at 20℃; Title compound not separated from byproducts.;
3-hydroxybutyric acid methyl ester
1487-49-6

3-hydroxybutyric acid methyl ester

A

(S)-3-hydroxybutyric acid methyl ester
53562-86-0

(S)-3-hydroxybutyric acid methyl ester

B

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
With air; cells of Geotrichum candidum IFO5767 In water at 30℃; for 24h; Product distribution;
With pentyl cage-coated capillary column Resolution of racemate;
With homochiral metal-organic cage [Zn3(deprotonated [3+3] macrocyclic Schiff base of trans-1,2-diaminocyclohexane and 4-tert-butyl-2,6-diformylphenol)2] coated capillary column In dichloromethane at 112℃; Resolution of racemate; enantioselective reaction;
acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

isopropyl alcohol
67-63-0

isopropyl alcohol

A

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

B

3,3-diisopropoxy-butyric acid methyl ester

3,3-diisopropoxy-butyric acid methyl ester

Conditions
ConditionsYield
With hydrogen; (S)-Ru-BINAP at 60℃; under 30002.4 Torr; for 1h; Product distribution; Further Variations:; Reagents; Solvents;
(R)-3-hydroxybutyric acid
625-72-9

(R)-3-hydroxybutyric acid

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Methyl 4-(4-Chlorophenylthio)-3-oxobutanoate
114607-75-9

Methyl 4-(4-Chlorophenylthio)-3-oxobutanoate

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Candida guilliermondii
2: 80 percent / Raney nickel
View Scheme
(4S,5R)-5-Methyl-2-oxo-[1,3]dioxolane-4-carboxylic acid methyl ester

(4S,5R)-5-Methyl-2-oxo-[1,3]dioxolane-4-carboxylic acid methyl ester

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 89 percent / Et3N / tetrahydrofuran / 1 h / 0 °C
2: 75 percent / Raney nickel / ethanol / 0.5 h / Ambient temperature
View Scheme
triisopropylsilyl trifluoromethanesulfonate
80522-42-5

triisopropylsilyl trifluoromethanesulfonate

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

methyl 3(R)-<oxy>butanoate
126249-06-7, 122358-09-2

methyl 3(R)-<oxy>butanoate

Conditions
ConditionsYield
With 2,6-dimethylpyridine for 3h; Ambient temperature;100%
With 2,6-dimethylpyridine In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;95%
Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

methyl (R)-(-)-3-(tert-butyldimethylsilyloxy)butyrate
104524-19-8

methyl (R)-(-)-3-(tert-butyldimethylsilyloxy)butyrate

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 23℃; for 12h; Addition;100%
With 1H-imidazole In dichloromethane at 0 - 20℃; for 18h; Inert atmosphere;100%
With 1H-imidazole In dichloromethane at 0 - 20℃; for 18h; Inert atmosphere;100%
(R)-methoxytrifluoromethylphenylacetyl chloride
20445-33-4, 39637-99-5

(R)-methoxytrifluoromethylphenylacetyl chloride

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

methyl (3R)-3-<(S)-(-)-α-methoxy-α-(trifluoromethyl)phenylacetyl>butyrate

methyl (3R)-3-<(S)-(-)-α-methoxy-α-(trifluoromethyl)phenylacetyl>butyrate

Conditions
ConditionsYield
With pyridine In tetrachloromethane for 12h; Ambient temperature;100%
Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

(S)-chlorofluoroacetic acid
25197-75-5

(S)-chlorofluoroacetic acid

Methyl (3R)-3-[(2S)-2-chloro-2-fluoroacetoxy]butanoate

Methyl (3R)-3-[(2S)-2-chloro-2-fluoroacetoxy]butanoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Esterification;100%
{ONOMe,Cumyl}Y[N(SiHMe2)2](THF)(Et2O)
1510836-92-6

{ONOMe,Cumyl}Y[N(SiHMe2)2](THF)(Et2O)

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

{ONOMe,Cumyl}Y((R)-OCH(CH3)CH2COOMe)

{ONOMe,Cumyl}Y((R)-OCH(CH3)CH2COOMe)

Conditions
ConditionsYield
In benzene-d6 for 0.166667h; Inert atmosphere; Glovebox;99%
Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

benzylamine
100-46-9

benzylamine

(R)-N-benzyl-3-hydroxybutanamide
146679-25-6

(R)-N-benzyl-3-hydroxybutanamide

Conditions
ConditionsYield
With ammonium nitrate In neat (no solvent) at 20℃; for 12h; Green chemistry;99%
Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

ethyl vinyl ether
109-92-2

ethyl vinyl ether

methyl (1'RS,3R)-3-(1-ethoxyethoxy)butyrate
208459-11-4

methyl (1'RS,3R)-3-(1-ethoxyethoxy)butyrate

Conditions
ConditionsYield
With trifluoroacetic acid for 12h; Ambient temperature;98%
With trifluoroacetic acid 1) 0 deg C, 22 h, 2) r.t., 3 h;94%
With pyridinium p-toluenesulfonate In dichloromethane at 20℃; for 24h;
Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

methyl (R)-3-(p-toluenesulfonyloxy)butyrate
91366-12-0

methyl (R)-3-(p-toluenesulfonyloxy)butyrate

Conditions
ConditionsYield
With pyridine at 0℃; for 24h;98%
With pyridine; triethylamine In toluene at 0 - 20℃; Inert atmosphere;84%
With pyridine Ambient temperature;82.4%
2-Methoxyethoxymethyl chloride
3970-21-6

2-Methoxyethoxymethyl chloride

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

(R)-3-(2-Methoxy-ethoxymethoxy)-butyric acid methyl ester
160482-01-9

(R)-3-(2-Methoxy-ethoxymethoxy)-butyric acid methyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane Ambient temperature;98%
Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

chloromethyl methyl ether
107-30-2

chloromethyl methyl ether

(R)-methyl 3-(methoxy)methoxybutyrate
99274-56-3

(R)-methyl 3-(methoxy)methoxybutyrate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine97%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃; for 42h;95%
With N-ethyl-N,N-diisopropylamine In dichloromethane
With N-ethyl-N,N-diisopropylamine In dichloromethane for 42h; Ambient temperature;
Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

(R)-3-(tert-Butyldiphenylsilanyloxy)butyric acid methyl ester
178246-78-1

(R)-3-(tert-Butyldiphenylsilanyloxy)butyric acid methyl ester

Conditions
ConditionsYield
Stage #1: Methyl (R)-3-hydroxybutyrate With 1H-imidazole In dichloromethane at 0℃; for 0.166667h;
Stage #2: tert-butylchlorodiphenylsilane In dichloromethane at 25℃; for 4h; Further stages.;
97%
Stage #1: Methyl (R)-3-hydroxybutyrate With 1H-imidazole In dichloromethane at 0℃; for 0.166667h; silylation;
Stage #2: tert-butylchlorodiphenylsilane In dichloromethane at 0 - 25℃; for 4h; silylation; Further stages.;
97%
With 1H-imidazole In dichloromethane at 20℃; for 4.5h;91.2%
3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

methyl (R)-3-tetrahydropyranyloxybutanoate
77234-51-6

methyl (R)-3-tetrahydropyranyloxybutanoate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In dichloromethane at 0℃; for 2h; Etherification;96%
With toluene-4-sulfonic acid In diethyl ether for 10h; Ambient temperature;91%
With toluene-4-sulfonic acid In diethyl ether at 0 - 25℃;65%
chlorodimethyl(1,1,2-trimethylpropyl)silane
67373-56-2

chlorodimethyl(1,1,2-trimethylpropyl)silane

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

(R)-3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-butyric acid methyl ester
133260-92-1

(R)-3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-butyric acid methyl ester

Conditions
ConditionsYield
96%
Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

4-methyl-benzoyl chloride
874-60-2

4-methyl-benzoyl chloride

4-Methyl-benzoic acid (R)-2-methoxycarbonyl-1-methyl-ethyl ester

4-Methyl-benzoic acid (R)-2-methoxycarbonyl-1-methyl-ethyl ester

Conditions
ConditionsYield
With 4-vinylpyridine In dichloromethane at 20℃; for 6h;96%
Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

O-(4-methoxybenzyl)-trichloroacetimidate
89238-99-3

O-(4-methoxybenzyl)-trichloroacetimidate

(R)-methyl 3-((4-methoxybenzyl)oxy)butanoate
185030-60-8

(R)-methyl 3-((4-methoxybenzyl)oxy)butanoate

Conditions
ConditionsYield
With camphor-10-sulfonic acid In dichloromethane at 20℃; for 36h; Etherification;95%
With camphorsulfonic acid In dichloromethane at 20℃; Inert atmosphere;94%
With camphor-10-sulfonic acid In dichloromethane at 20℃; Inert atmosphere;93.7%
Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

C8H15NO3

C8H15NO3

Conditions
ConditionsYield
In 2-methyltetrahydrofuran at 90℃; for 3h; Solvent; Temperature; Large scale;95%
In dichloromethane at 90℃; for 4h; Solvent; Temperature; Large scale;
Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

(R)-3-hydroxybutyric acid
625-72-9

(R)-3-hydroxybutyric acid

Conditions
ConditionsYield
Stage #1: Methyl (R)-3-hydroxybutyrate With potassium hydroxide In water at 0 - 20℃; for 48h; Inert atmosphere;
Stage #2: With hydrogenchloride In water pH=1; Inert atmosphere;
94%
With potassium hydroxide In water at 4℃; for 480h;91%
Stage #1: Methyl (R)-3-hydroxybutyrate With potassium hydroxide; water at 0℃; for 25.5h;
Stage #2: With hydrogenchloride; water at 5℃;
87%
Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

aniline
62-53-3

aniline

A

methyl (R)-3-(phenylamino)butanoate
63430-94-4

methyl (R)-3-(phenylamino)butanoate

B

(S)-phenylamino-butyric acid methyl ester
142826-92-4

(S)-phenylamino-butyric acid methyl ester

Conditions
ConditionsYield
Stage #1: Methyl (R)-3-hydroxybutyrate With trifluoromethanesulfonic acid anhydride; diisopropylamine In dichloromethane at -78℃; for 1h;
Stage #2: aniline at -78 - -40℃; for 16h;
A n/a
B 94%
Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

benzyl bromide
100-39-0

benzyl bromide

(R)-3-(benzyloxy)butanoic acid methyl ester
116761-24-1

(R)-3-(benzyloxy)butanoic acid methyl ester

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide; sodium hydride In tetrahydrofuran at 20℃; Inert atmosphere;94%
Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

O-(4-methoxybenzyl)-trichloroacetimidate
89238-99-3

O-(4-methoxybenzyl)-trichloroacetimidate

(R)-methyl 3-((4-methoxybenzyl)oxy)butanoate

(R)-methyl 3-((4-methoxybenzyl)oxy)butanoate

Conditions
ConditionsYield
With camphor-10-sulfonic acid In dichloromethane at 0 - 20℃;94%
Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

sodium (R)-3-hydroxybutyrate
13613-65-5

sodium (R)-3-hydroxybutyrate

Conditions
ConditionsYield
With water; sodium hydroxide In methanol at 15℃; for 12h; Inert atmosphere;93.69%
With sodium hydroxide In water at 10 - 30℃; for 6h;85%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

methyl (R)-(-)-3-(tert-butyldimethylsilyloxy)butyrate
104524-19-8

methyl (R)-(-)-3-(tert-butyldimethylsilyloxy)butyrate

Conditions
ConditionsYield
With 1H-imidazole In dichloromethane at 20℃; for 23h;92%
Methyl (R)-3-hydroxybutyrate
3976-69-0

Methyl (R)-3-hydroxybutyrate

calcium (R)-3-hydroxybutyrate

calcium (R)-3-hydroxybutyrate

Conditions
ConditionsYield
With calcium hydroxide In water at 8℃; for 6h;91.1%

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