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inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryChemical Name Methyl (R)-(-)-3-hydroxybutyrate Synonyms (R)-(-)-methyl 3-hydroxybutyrate CAS No. 3976-69-0 EINECS No. 223-610-0
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryMethyl (R)-(-)-3-hydroxybutyrate CAS:3976-69-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality o
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiry3976-69-0Appearance:white powder Storage:keep cold Package:according to customers' requirements Application:Pharmaceutical intermediates 3976-69-0 Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or accordin
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inquiryMethyl (R)-(-)-3-hydroxybutyrate Basic information Product Name: Methyl (R)-(-)-3-hydroxybutyrate Synonyms: METHYL 3-HYDROXYBUTANOATE;Methyl-3-hydroxybutyrate;METHYL (R)-(-)-3-HYDROXYBUTYRATE;METHYL (R)-3-HYDROXYBUTYRATE;METHYL D-(R)-3-HYDROXY
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquiryProduct name Methyl R-3-hydroxybutanoate Content ≥98% CAS NO. 3976-69-0 Package Structure Formula Appearance:Colorl
Cas:3976-69-0
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inquirydiazomethane
(R)-3-hydroxybutyric acid
Methyl (R)-3-hydroxybutyrate
Conditions | Yield |
---|---|
In diethyl ether | 100% |
In methanol; diethyl ether at -10℃; | 76% |
acetoacetic acid methyl ester
A
(S)-3-hydroxybutyric acid methyl ester
B
Methyl (R)-3-hydroxybutyrate
Conditions | Yield |
---|---|
With Ru2Cl4-(S)-(2,2'-bis(diphenylphosphino)-1,1'-binaphthyl)2*NEt3; hydrogen In methanol at 35℃; under 76000.1 Torr; for 48h; Title compound not separated from byproducts; | A 100% B n/a |
With <((R)-(1,1'-binaphthyl-2,2'-diyl)bis(diphenylphosphine))RuCl2>2NEt3; hydrogen In methanol at 35℃; under 76000.1 Torr; for 48h; Title compound not separated from byproducts; | A n/a B 100% |
With hydrogen; Ru(BICP)Br2 In methanol at 40 - 65℃; under 750.075 - 3750.38 Torr; | A n/a B 95% |
Conditions | Yield |
---|---|
With cat; hydrogen In methanol; dichloromethane at 25℃; under 77572.2 Torr; for 48h; | 100% |
With (R)-MeOBiphepRuBr2; hydrogen In methanol at 50℃; under 15200 Torr; for 48h; | 100% |
With (S)-4,12-bis(diphenylphosphino)-<2.2>paracyclophane-Ru(II)bis(trifluoroacetate); hydrogen; tetra-(n-butyl)ammonium iodide In methanol; water at -5℃; under 2585.7 Torr; for 18h; | 100% |
Conditions | Yield |
---|---|
scandium tris(trifluoromethanesulfonate) at 64℃; for 10h; | 98% |
(EtO)3TiO(CH2)2OTi(OEt)3 autoclave, 1.) 160 deg C, 17 bar, 2 h; 2.) 115 deg C, 3.5 bar, 27 h; | 82% |
tert-butyl acetoacetate
A
Methyl (R)-3-hydroxybutyrate
B
tert-butyl (R)-3-hydroxybutanoate
Conditions | Yield |
---|---|
With hydrogenchloride; hydrogen; [RuCl2-((R)-binap)]*NEt3 In methanol at 40℃; under 2585.7 Torr; for 8h; Kinetics; effect of acid, other substrate; | A 3% B 97% |
With hydrogenchloride; hydrogen; <(R)-(BINAP)RuCl2>2*NEt3 In methanol at 40℃; under 2585.7 Torr; for 8h; | A 3% B 97% |
acetoacetic acid methyl ester
A
(S)-3-hydroxybutyric acid methyl ester
B
Methyl (R)-3-hydroxybutyrate
C
3,3-bismethoxybutyric acid methyl ester
Conditions | Yield |
---|---|
With hydrogen; {RuI((R)-2,2'-bis(diphenylphospino)-1,1'-binaphthyl)(p-cymene)}I In methanol at 30℃; under 76000 Torr; for 35h; Product distribution; other: catalysts, solvents, time, pressure, temperatures; | A 97% B n/a C 3% |
methanol
carbon monoxide
(R)-propylene oxide
Methyl (R)-3-hydroxybutyrate
Conditions | Yield |
---|---|
With 3-HYDROXYPYRIDINE; dicobalt octacarbonyl In tetrahydrofuran at 65℃; under 31028.9 Torr; for 9h; | 92% |
(S)-3-Hydroxy-4-((R)-toluene-4-sulfinyl)-butyric acid methyl ester
Methyl (R)-3-hydroxybutyrate
Conditions | Yield |
---|---|
With nickel | 90% |
methanol
A
methyl (3R)-3-hydroxypentanoate
B
Methyl (R)-3-hydroxybutyrate
Conditions | Yield |
---|---|
With sulfuric acid In 1,2-dichloro-ethane for 48h; Heating; | A 62% B 87% |
Methyl (S)-4-(p-Chlorophenylthio)-3-hydroxybutanoate
Methyl (R)-3-hydroxybutyrate
Conditions | Yield |
---|---|
nickel | 80% |
Conditions | Yield |
---|---|
With sulfuric acid In dichloromethane for 48h; Heating; | 78% |
Methyl (R)-3-hydroxybutyrate
Conditions | Yield |
---|---|
With nickel In ethanol for 0.5h; Ambient temperature; | 75% |
Conditions | Yield |
---|---|
With sulfuric acid In 1,2-dichloro-ethane at 80℃; for 120h; Heating / reflux; | 73% |
Methyl (R)-3-hydroxybutyrate
Conditions | Yield |
---|---|
With sulfuric acid In methanol; 1,2-dichloro-ethane for 72h; depolymerization; Heating; | 71% |
(R)-methyl 3-(dimethyl(phenyl)silyl)butanoate
Methyl (R)-3-hydroxybutyrate
Conditions | Yield |
---|---|
With peracetic acid; palladium diacetate; mercury(II) diacetate In acetic acid for 2h; Ambient temperature; | 43% |
diazomethane
3-Hydroxybutyric acid
Methyl (R)-3-hydroxybutyrate
Conditions | Yield |
---|---|
In diethyl ether |
Methyl (R)-3-hydroxybutyrate
Conditions | Yield |
---|---|
With Raney Ni W-4 Yield given; |
(R)-3-(benzyloxy)butanoic acid methyl ester
Methyl (R)-3-hydroxybutyrate
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In acetic acid Product distribution; Ambient temperature; |
Conditions | Yield |
---|---|
With sulfuric acid |
Conditions | Yield |
---|---|
With sulfuric acid 1.) 1,2-dichloroethane, reflux, 2 h; 2.) reflux, 48 h; Yield given. Multistep reaction; |
methanol
A
methyl (3R)-3-hydroxypentanoate
B
Methyl (R)-3-hydroxybutyrate
Conditions | Yield |
---|---|
With sulfuric acid 1.) 1,2-dichloroethane, reflux, 1 h; 2.) 1,2-dichloroethane, reflux, 3 d; Yield given. Multistep reaction. Yields of byproduct given; |
Conditions | Yield |
---|---|
With sulfuric acid; toluene-4-sulfonic acid 1.) 1,2-dichloroethane, reflux, 34 h; 2.) 1,2-dichloroethane, reflux, 12 h; Yield given; Multistep reaction; |
diazomethane
(+)-macrosphelide E
A
Methyl (R)-3-hydroxybutyrate
B
methyl (E,4R,5S)-4,5-dihydroxy-2-hexenoate
Conditions | Yield |
---|---|
Stage #1: (+)-macrosphelide E With potassium carbonate In methanol at 20℃; Stage #2: diazomethane In diethyl ether at 20℃; for 2h; Further stages.; |
methanol
(+)-macrosphelide E
A
Methyl (R)-3-hydroxybutyrate
B
methyl (E,4R,5S)-4,5-dihydroxy-2-hexenoate
Conditions | Yield |
---|---|
With sulfuric acid at 20℃; Title compound not separated from byproducts.; |
3-hydroxybutyric acid methyl ester
A
(S)-3-hydroxybutyric acid methyl ester
B
Methyl (R)-3-hydroxybutyrate
Conditions | Yield |
---|---|
With air; cells of Geotrichum candidum IFO5767 In water at 30℃; for 24h; Product distribution; | |
With pentyl cage-coated capillary column Resolution of racemate; | |
With homochiral metal-organic cage [Zn3(deprotonated [3+3] macrocyclic Schiff base of trans-1,2-diaminocyclohexane and 4-tert-butyl-2,6-diformylphenol)2] coated capillary column In dichloromethane at 112℃; Resolution of racemate; enantioselective reaction; |
acetoacetic acid methyl ester
isopropyl alcohol
A
Methyl (R)-3-hydroxybutyrate
Conditions | Yield |
---|---|
With hydrogen; (S)-Ru-BINAP at 60℃; under 30002.4 Torr; for 1h; Product distribution; Further Variations:; Reagents; Solvents; |
(R)-3-hydroxybutyric acid
diazomethyl-trimethyl-silane
Methyl (R)-3-hydroxybutyrate
Methyl 4-(4-Chlorophenylthio)-3-oxobutanoate
Methyl (R)-3-hydroxybutyrate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Candida guilliermondii 2: 80 percent / Raney nickel View Scheme |
Methyl (R)-3-hydroxybutyrate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 89 percent / Et3N / tetrahydrofuran / 1 h / 0 °C 2: 75 percent / Raney nickel / ethanol / 0.5 h / Ambient temperature View Scheme |
triisopropylsilyl trifluoromethanesulfonate
Methyl (R)-3-hydroxybutyrate
methyl 3(R)-<oxy>butanoate
Conditions | Yield |
---|---|
With 2,6-dimethylpyridine for 3h; Ambient temperature; | 100% |
With 2,6-dimethylpyridine In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere; | 95% |
Methyl (R)-3-hydroxybutyrate
tert-butyldimethylsilyl chloride
methyl (R)-(-)-3-(tert-butyldimethylsilyloxy)butyrate
Conditions | Yield |
---|---|
With 1H-imidazole In N,N-dimethyl-formamide at 23℃; for 12h; Addition; | 100% |
With 1H-imidazole In dichloromethane at 0 - 20℃; for 18h; Inert atmosphere; | 100% |
With 1H-imidazole In dichloromethane at 0 - 20℃; for 18h; Inert atmosphere; | 100% |
(R)-methoxytrifluoromethylphenylacetyl chloride
Methyl (R)-3-hydroxybutyrate
Conditions | Yield |
---|---|
With pyridine In tetrachloromethane for 12h; Ambient temperature; | 100% |
Methyl (R)-3-hydroxybutyrate
(S)-chlorofluoroacetic acid
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Esterification; | 100% |
{ONOMe,Cumyl}Y[N(SiHMe2)2](THF)(Et2O)
Methyl (R)-3-hydroxybutyrate
Conditions | Yield |
---|---|
In benzene-d6 for 0.166667h; Inert atmosphere; Glovebox; | 99% |
Methyl (R)-3-hydroxybutyrate
benzylamine
(R)-N-benzyl-3-hydroxybutanamide
Conditions | Yield |
---|---|
With ammonium nitrate In neat (no solvent) at 20℃; for 12h; Green chemistry; | 99% |
Methyl (R)-3-hydroxybutyrate
ethyl vinyl ether
methyl (1'RS,3R)-3-(1-ethoxyethoxy)butyrate
Conditions | Yield |
---|---|
With trifluoroacetic acid for 12h; Ambient temperature; | 98% |
With trifluoroacetic acid 1) 0 deg C, 22 h, 2) r.t., 3 h; | 94% |
With pyridinium p-toluenesulfonate In dichloromethane at 20℃; for 24h; |
Methyl (R)-3-hydroxybutyrate
p-toluenesulfonyl chloride
methyl (R)-3-(p-toluenesulfonyloxy)butyrate
Conditions | Yield |
---|---|
With pyridine at 0℃; for 24h; | 98% |
With pyridine; triethylamine In toluene at 0 - 20℃; Inert atmosphere; | 84% |
With pyridine Ambient temperature; | 82.4% |
2-Methoxyethoxymethyl chloride
Methyl (R)-3-hydroxybutyrate
(R)-3-(2-Methoxy-ethoxymethoxy)-butyric acid methyl ester
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane Ambient temperature; | 98% |
Methyl (R)-3-hydroxybutyrate
chloromethyl methyl ether
(R)-methyl 3-(methoxy)methoxybutyrate
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine | 97% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃; for 42h; | 95% |
With N-ethyl-N,N-diisopropylamine In dichloromethane | |
With N-ethyl-N,N-diisopropylamine In dichloromethane for 42h; Ambient temperature; |
Methyl (R)-3-hydroxybutyrate
tert-butylchlorodiphenylsilane
(R)-3-(tert-Butyldiphenylsilanyloxy)butyric acid methyl ester
Conditions | Yield |
---|---|
Stage #1: Methyl (R)-3-hydroxybutyrate With 1H-imidazole In dichloromethane at 0℃; for 0.166667h; Stage #2: tert-butylchlorodiphenylsilane In dichloromethane at 25℃; for 4h; Further stages.; | 97% |
Stage #1: Methyl (R)-3-hydroxybutyrate With 1H-imidazole In dichloromethane at 0℃; for 0.166667h; silylation; Stage #2: tert-butylchlorodiphenylsilane In dichloromethane at 0 - 25℃; for 4h; silylation; Further stages.; | 97% |
With 1H-imidazole In dichloromethane at 20℃; for 4.5h; | 91.2% |
3,4-dihydro-2H-pyran
Methyl (R)-3-hydroxybutyrate
methyl (R)-3-tetrahydropyranyloxybutanoate
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In dichloromethane at 0℃; for 2h; Etherification; | 96% |
With toluene-4-sulfonic acid In diethyl ether for 10h; Ambient temperature; | 91% |
With toluene-4-sulfonic acid In diethyl ether at 0 - 25℃; | 65% |
chlorodimethyl(1,1,2-trimethylpropyl)silane
Methyl (R)-3-hydroxybutyrate
(R)-3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-butyric acid methyl ester
Conditions | Yield |
---|---|
96% |
Conditions | Yield |
---|---|
With 4-vinylpyridine In dichloromethane at 20℃; for 6h; | 96% |
Methyl (R)-3-hydroxybutyrate
O-(4-methoxybenzyl)-trichloroacetimidate
(R)-methyl 3-((4-methoxybenzyl)oxy)butanoate
Conditions | Yield |
---|---|
With camphor-10-sulfonic acid In dichloromethane at 20℃; for 36h; Etherification; | 95% |
With camphorsulfonic acid In dichloromethane at 20℃; Inert atmosphere; | 94% |
With camphor-10-sulfonic acid In dichloromethane at 20℃; Inert atmosphere; | 93.7% |
Conditions | Yield |
---|---|
In 2-methyltetrahydrofuran at 90℃; for 3h; Solvent; Temperature; Large scale; | 95% |
In dichloromethane at 90℃; for 4h; Solvent; Temperature; Large scale; |
Conditions | Yield |
---|---|
Stage #1: Methyl (R)-3-hydroxybutyrate With potassium hydroxide In water at 0 - 20℃; for 48h; Inert atmosphere; Stage #2: With hydrogenchloride In water pH=1; Inert atmosphere; | 94% |
With potassium hydroxide In water at 4℃; for 480h; | 91% |
Stage #1: Methyl (R)-3-hydroxybutyrate With potassium hydroxide; water at 0℃; for 25.5h; Stage #2: With hydrogenchloride; water at 5℃; | 87% |
Methyl (R)-3-hydroxybutyrate
aniline
A
methyl (R)-3-(phenylamino)butanoate
B
(S)-phenylamino-butyric acid methyl ester
Conditions | Yield |
---|---|
Stage #1: Methyl (R)-3-hydroxybutyrate With trifluoromethanesulfonic acid anhydride; diisopropylamine In dichloromethane at -78℃; for 1h; Stage #2: aniline at -78 - -40℃; for 16h; | A n/a B 94% |
Methyl (R)-3-hydroxybutyrate
benzyl bromide
(R)-3-(benzyloxy)butanoic acid methyl ester
Conditions | Yield |
---|---|
With tetra-(n-butyl)ammonium iodide; sodium hydride In tetrahydrofuran at 20℃; Inert atmosphere; | 94% |
Methyl (R)-3-hydroxybutyrate
O-(4-methoxybenzyl)-trichloroacetimidate
Conditions | Yield |
---|---|
With camphor-10-sulfonic acid In dichloromethane at 0 - 20℃; | 94% |
Methyl (R)-3-hydroxybutyrate
sodium (R)-3-hydroxybutyrate
Conditions | Yield |
---|---|
With water; sodium hydroxide In methanol at 15℃; for 12h; Inert atmosphere; | 93.69% |
With sodium hydroxide In water at 10 - 30℃; for 6h; | 85% |
chloro-trimethyl-silane
Methyl (R)-3-hydroxybutyrate
methyl (R)-(-)-3-(tert-butyldimethylsilyloxy)butyrate
Conditions | Yield |
---|---|
With 1H-imidazole In dichloromethane at 20℃; for 23h; | 92% |
Methyl (R)-3-hydroxybutyrate
Conditions | Yield |
---|---|
With calcium hydroxide In water at 8℃; for 6h; | 91.1% |
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