Multi-target purpose intermediate with wide usage Commercial production from grams to tons, with technical documents package support, and audit and inspection support. With high purity and optimized and stable process. Self Innovation Appeara
Cas:15914-84-8
Min.Order:10 Gram
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Type:Manufacturers
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:15914-84-8
Min.Order:1 Metric Ton
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Type:Manufacturers
inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:15914-84-8
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the
Cas:15914-84-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ
Cas:15914-84-8
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiry(S)-(-)-ALPHA-METHYL-1-NAPHTHALENEMETHANOL CAS:15914-84-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in hig
Cas:15914-84-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:15914-84-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe,
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Min.Order:1 Kilogram
FOB Price: $80.0 / 100.0
Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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Negotiable
Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:15914-84-8
Min.Order:1 Gram
FOB Price: $591.0
Type:Trading Company
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:15914-84-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:15914-84-8
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:15914-84-8
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediates Tr
Cas:15914-84-8
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developmen
Cas:15914-84-8
Min.Order:1 Kilogram
FOB Price: $2.0 / 6.0
Type:Trading Company
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:15914-84-8
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
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inquiryHunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as
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Min.Order:0 Metric Ton
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Type:Manufacturers
inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
Cas:15914-84-8
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Lab/Research institutions
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:15914-84-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquirySAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe
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Min.Order:0
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Type:Lab/Research institutions
inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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Min.Order:0
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Type:Lab/Research institutions
inquiryGOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
Cas:15914-84-8
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry1'-naphthacetophenone
(S)-1-(1-Naphthyl)ethanol
Conditions | Yield |
---|---|
With [(R,R,R)-Ru(BINAP-PO3H2)(DPEN)Cl2] on magnetite nanoparticle; potassium tert-butylate; hydrogen In isopropyl alcohol at 20℃; under 36200.4 Torr; for 20h; | 100% |
With potassium hydroxide; (R,R)-1,2-diphenylethylenediamine; hydrogen; [RuCl2((R)-3,3'-dm-binap)(dmf)n] In isopropyl alcohol at 20℃; under 6080 Torr; | 99% |
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; C53H73FeN2O2PS; hydrogen; lithium tert-butoxide In isopropyl alcohol at 60℃; under 22801.5 Torr; for 12h; Autoclave; enantioselective reaction; | 99% |
1'-naphthacetophenone
A
(S)-1-(1-Naphthyl)ethanol
B
(R)-1-(naphth-1-yl)ethanol
Conditions | Yield |
---|---|
With dimethylsulfide borane complex; (S)-2-(anilinodiphenylmethyl)pyrrolidine In tetrahydrofuran at 20℃; for 2h; enantioselective reaction; | A n/a B 99% |
With dimethylsulfide borane complex In tetrahydrofuran at 20℃; for 2h; enantioselective reaction; | A n/a B 99% |
With (mer-[(S,S)-1,5-dimethyl-2,4-bis(4-phenyl-1,3-oxazolin-2-yl)benzene(1-)]Ru(CO)Cl)2(ZnCl2); hydrogen; sodium methylate In isopropyl alcohol at 40℃; under 22801.5 Torr; for 24h; Inert atmosphere; Autoclave; optical yield given as %ee; enantioselective reaction; | A 96% B n/a |
Conditions | Yield |
---|---|
With Novozyme 435 In toluene at 34℃; for 15h; Enzymatic reaction; | A 97.8% B n/a |
Isopropenyl acetate
1-(1-naphthyl)ethanol
A
(S)-1-(1-Naphthyl)ethanol
B
(R)-1-(naphth-1-yl)ethanol
C
1-(naphthalen-1-yl)ethyl acetate
Conditions | Yield |
---|---|
With Candida antarctica lipase B; dicarbonyl(chloro)(η5-pentaphenylcyclopentadienyl)ruthenium(II); potassium tert-butylate; sodium carbonate In tetrahydrofuran; toluene at 20℃; for 24h; | A n/a B n/a C 97% |
With lipase B from Candida antarctica In neat (no solvent) for 4h; Milling; Resolution of racemate; Enzymatic reaction; enantioselective reaction; | A n/a B n/a C n/a |
2,2,2-trichloroethyl butyrate
1-(1-naphthyl)ethanol
A
(S)-1-(1-Naphthyl)ethanol
B
(R)-1-(1'-naphthyl)ethyl butyrate
Conditions | Yield |
---|---|
With porcine pancreatic lipase In n-heptane at 60℃; for 336h; | A 94% B 96% |
vinyl n-butyrate
1-(1-naphthyl)ethanol
A
(S)-1-(1-Naphthyl)ethanol
B
(R)-1-(1'-naphthyl)ethyl butyrate
Conditions | Yield |
---|---|
With Novozyme 435 In toluene at 37℃; for 18h; Enzymatic reaction; | A 95.4% B n/a |
Conditions | Yield |
---|---|
With Novozyme 435 In toluene at 40℃; for 20h; Enzymatic reaction; | A 90.3% B n/a |
vinyl octanoate
1-(1-naphthyl)ethanol
A
(S)-1-(1-Naphthyl)ethanol
B
C20H26O2
Conditions | Yield |
---|---|
With lipase B from Candida antarctica In cyclohexane at 50℃; for 1.75h; Resolution of racemate; optical yield given as %ee; | A n/a B 90% |
Conditions | Yield |
---|---|
Stage #1: dimethyl zinc(II); 1-naphthaldehyde With N,N-bis(3,5-di-t-butylbenzyl)-O-benzyl-L-α-aspartyl-L-proline methyl ester In toluene at 0 - 20℃; for 48h; Inert atmosphere; Stage #2: With hydrogenchloride In water; toluene Inert atmosphere; optical yield given as %ee; enantioselective reaction; | 74% |
1-(1-naphthyl)ethanol
A
1'-naphthacetophenone
B
(S)-1-(1-Naphthyl)ethanol
C
(R)-1-(naphth-1-yl)ethanol
Conditions | Yield |
---|---|
With (1R)-N-oxyl-1-(N-benzylcarbamoyl)-8-azabicyclo[3.2.1]octane; sodium hydrogencarbonate; sodium bromide In dichloromethane; water at 0℃; Electrochemical reaction; optical yield given as %ee; enantioselective reaction; | A 62% B n/a C n/a |
With palladium dichloro (η-2,5-norbornadiene); oxygen; (-)-sparteine In toluene at 80℃; for 192h; Title compound not separated from byproducts; | A 54% B n/a C n/a |
With 3 A molecular sieve; oxygen; (-)-sparteine; palladium dichloro (η-2,5-norbornadiene) In toluene at 80℃; under 760 Torr; for 192h; | A 54% B n/a C n/a |
vinyl acetate
1-(1-naphthyl)ethanol
A
(S)-1-(1-Naphthyl)ethanol
B
(R)-1-(naphth-1-yl)ethanol
C
1-(naphthalen-1-yl)ethyl acetate
Conditions | Yield |
---|---|
With lipase LIP In octane at 30℃; for 0.15h; Yields of byproduct given; | A n/a B n/a C 46% |
With 4 Anstroem molecular sives; lipase LIP In di-isopropyl ether at 30℃; for 4h; Yields of byproduct given; | A n/a B n/a C 36% |
In di-isopropyl ether at 35℃; for 0.666667h; Kinetics; Reagent/catalyst; Solvent; Enzymatic reaction; enantioselective reaction; | A n/a B n/a C 21.1% |
With Burkholderia cepacia lipase; C36H73O14S(1-)*C7H10N(1+) at 35℃; for 2.33333h; Resolution of racemate; Enzymatic reaction; enantioselective reaction; | A n/a B n/a C 12% |
With IL1; Lipase PS-C In di-isopropyl ether at 35℃; for 24h; | A n/a B n/a C 11% |
1-(1-naphthyl)ethanol
(S)-1-(1-Naphthyl)ethanol
Conditions | Yield |
---|---|
With C46H34I4O6; 1,1,1,3,3,3-hexamethyl-disilazane In dichloromethane at -30℃; for 2h; Reagent/catalyst; Temperature; stereoselective reaction; | 45% |
With C45H32I4O6; 1,1,1,3,3,3-hexamethyl-disilazane In dichloromethane at -30℃; for 2h; stereoselective reaction; | 45% |
1-(1-naphthyl)ethanol
A
(S)-1-(1-Naphthyl)ethanol
B
(S)-(-)-1-(naphthalen-1-yl)ethyl acetate
C
1-(naphthalen-1-yl)ethyl acetate
Conditions | Yield |
---|---|
With vinyl acetate; Lipase PS In octane at 30℃; for 8h; Yields of byproduct given; | A 45% B n/a C n/a |
vinyl acetate
1-(1-naphthyl)ethanol
A
(S)-1-(1-Naphthyl)ethanol
B
1-(naphthalen-1-yl)ethyl acetate
Conditions | Yield |
---|---|
With Candida antarctica lipase B In 1,1,1,2-tetrafluoroethane at 25℃; for 72h; Resolution of racemate; Enzymatic reaction; optical yield given as %ee; | A n/a B 45% |
With Candida antarctica lipase B In diethyl ether at 20℃; Enzymatic reaction; | A 33% B 33% |
With 50 U aminoacylase E.C. 3.5.1.14 In hexane for 168h; Acetylation; | A n/a B 22% |
With Novozyme 435 In toluene at 30℃; for 12h; Enzymatic reaction; Overall yield = 98.8%; Overall yield = 58.4 g; | A n/a B n/a |
1'-naphthacetophenone
Isopropenyl acetate
A
(S)-1-(1-Naphthyl)ethanol
B
(R)-1-(naphth-1-yl)ethanol
C
1-(naphthalen-1-yl)ethyl acetate
Conditions | Yield |
---|---|
Stage #1: 1'-naphthacetophenone With aluminum oxide; sodium tetrahydroborate In hexane at 40℃; for 3h; Stage #2: Isopropenyl acetate With Lipase 'Amano' PS-C II In hexane at 25℃; for 12h; | A n/a B n/a C 42% |
1-(1-naphthyl)ethanol
A
1'-naphthacetophenone
B
(S)-1-(1-Naphthyl)ethanol
Conditions | Yield |
---|---|
With sodium hydrogencarbonate; sodium bromide; chiral azabicyclo-N-oxyl In dichloromethane at 0℃; Electrochemical reaction; | A 40% B n/a |
With [palladium(II)((-)-sparteine)dibromide]; oxygen; caesium carbonate; (-)-sparteine In chloroform at 23℃; for 21h; Molecular sieve; optical yield given as %ee; |
1-(1-naphthyl)ethanol
propionic acid anhydride
A
(S)-1-(1-Naphthyl)ethanol
Conditions | Yield |
---|---|
With (2S,3R)-3-isopropyl-2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine; N-ethyl-N,N-diisopropylamine In chloroform at 20 - 25℃; for 28h; optical yield given as %ee; enantioselective reaction; | A 39% B n/a C n/a |
With (R)-7-chloro-2-phenyl-2,3-dihydroimidazo[1,2-a]quinoline; N-ethyl-N,N-diisopropylamine In chloroform at 0℃; for 8h; |
1-(1-naphthyl)ethanol
propionic acid anhydride
A
(S)-1-(1-Naphthyl)ethanol
B
(R)-1-(naphth-1-yl)ethanol
Conditions | Yield |
---|---|
With (2S,3R)-3-isopropyl-2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine; N-ethyl-N,N-diisopropylamine In toluene at -40℃; for 1h; optical yield given as %ee; enantioselective reaction; | A 39% B n/a C n/a |
ethene
1-Bromonaphthalene
bis(pinacol)diborane
A
(S)-1-(1-Naphthyl)ethanol
B
(R)-1-(naphth-1-yl)ethanol
Conditions | Yield |
---|---|
Stage #1: ethene; 1-Bromonaphthalene; bis(pinacol)diborane With (1,2-dimethoxyethane)dichloronickel(II); (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; lithium methanolate In 1,4-dioxane at 30℃; for 20h; Glovebox; Inert atmosphere; Sealed tube; Stage #2: With dihydrogen peroxide; sodium hydroxide In tetrahydrofuran; water at 0 - 25℃; Overall yield = 38 percent; Optical yield = 70 percent ee; | A n/a B 38% |
Isopropenyl acetate
1-(1-naphthyl)ethanol
A
(S)-1-(1-Naphthyl)ethanol
B
1-(naphthalen-1-yl)ethyl acetate
Conditions | Yield |
---|---|
With Candida antarctica lipase B In diethyl ether at 20℃; Enzymatic reaction; | A 31% B 31% |
With potassium phosphate; Novozym 435; (CO)2ClRu(benzyloxytetraphenylpentadienyl) In toluene at 25℃; for 20h; | |
With immobilized Candida antarctica Lipase B In diethyl ether at 20℃; for 30h; |
1-ethylnapthelene
A
1'-naphthacetophenone
B
(S)-1-(1-Naphthyl)ethanol
C
(R)-1-(naphth-1-yl)ethanol
Conditions | Yield |
---|---|
With iodosylbenzene; iron(III) meso-tetraphenylporhinato chloride In dichloromethane at 0℃; for 1h; Yield given. Yields of byproduct given; |
1-(1-naphthyl)ethanol
A
(S)-1-(1-Naphthyl)ethanol
B
(R)-1-(naphth-1-yl)ethanol
Conditions | Yield |
---|---|
hydrolysis of (+)-hydrogen phthalate salt; | |
Stage #1: 1-(1-naphthyl)ethanol With (R,R)-1,2-diphenylethylenediamine; cyclohexanone; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; dihydridotetrakis(triphenylphosphine)ruthenium In tetrahydrofuran at 60℃; for 4h; Stage #2: With hydrogen In tetrahydrofuran at 40℃; under 7500.6 Torr; for 16h; Title compound not separated from byproducts; | |
With MCCD-HPS packed column In hydrogenchloride; acetonitrile pH=8.6; |
dimethyl zinc(II)
1-naphthaldehyde
A
(S)-1-(1-Naphthyl)ethanol
B
(R)-1-(naphth-1-yl)ethanol
Conditions | Yield |
---|---|
With tricarbonyl(η6-arene)chromium(0) complex derived from (1S,2R)-N,N-dibutylnorephedrine In hexane; toluene at 0℃; for 12h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; | |
With (1S,2S,5R)-1-N,N-dimethylaminopropyl-2-isopropyl-5-methylcyclohexan-1-ol In diethyl ether for 160h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; | |
With Boc-(S)-CH(i-Pr)-CONHCH2CH2-(morpholin-4-yl) In hexane at 0℃; Title compound not separated from byproducts; |
methylmagnesium chloride
1-naphthaldehyde
A
(S)-1-(1-Naphthyl)ethanol
B
(R)-1-(naphth-1-yl)ethanol
Conditions | Yield |
---|---|
With C9H21ClO3Ti*C9H18O2 In tetrahydrofuran Yield given. Yields of byproduct given; | |
Stage #1: methylmagnesium chloride With titanium(IV) isopropylate In dichloromethane at -78℃; for 0.166667h; Inert atmosphere; Stage #2: 1-naphthaldehyde With (R)-3-(3,5-diphenylphenyl)-2,2'-dihydroxy-1,1'-binaphthyl In tetrahydrofuran; dichloromethane at 0℃; for 3h; Inert atmosphere; Stage #3: With hydrogenchloride; water In tetrahydrofuran; dichloromethane at 0℃; Inert atmosphere; optical yield given as %ee; enantioselective reaction; |
1-naphthaldehyde
tetramethyl titanium
A
(S)-1-(1-Naphthyl)ethanol
B
(R)-1-(naphth-1-yl)ethanol
Conditions | Yield |
---|---|
With isopropyl alcohol; trans-N-(1-hydroxy-1-phenylpropan-2-yl)-4-methylbenzenesulfonamide Product distribution; 1.) ether, 30 min, -30 to -10 grad C, 2.) from -78 grad C to room temp., overnight; Further sulphonamide derivatives of norephedrine were investigated.; | |
With norephedrine mesitylsulphonamide; isopropyl alcohol 1.) ether, 30 min, -30 to -10 grad C, 2.) from -78 grad C to room temp., overnight; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; |
Conditions | Yield |
---|---|
at -60 - 20℃; for 3h; |
C42H70O35*C12H10O
A
(S)-1-(1-Naphthyl)ethanol
B
(R)-1-(naphth-1-yl)ethanol
Conditions | Yield |
---|---|
With sodium tetrahydroborate In solid for 120h; Product distribution; Ambient temperature; other variant: ultrasonic irradiation, 2 d; |
1-(1-naphthyl)ethanol
A
(S)-1-(1-Naphthyl)ethanol
B
(R)-1-(naphth-1-yl)ethanol
C
1-(naphthalen-1-yl)ethyl acetate
Conditions | Yield |
---|---|
With vinyl acetate; 4 Anstroem molecular sives; lipase LIP In di-isopropyl ether at 30℃; for 3h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
A
(S)-1-(1-Naphthyl)ethanol
B
(R)-1-(naphth-1-yl)ethanol
Conditions | Yield |
---|---|
With sodium hydroxide In tetrahydrofuran; methanol for 3h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
N,N-diisopropylcarbamoyl chloride
(S)-1-(1-Naphthyl)ethanol
(S)-N,N-diisopropyl O-[1-(1-naphthyl)]ethyl carbamate
Conditions | Yield |
---|---|
Stage #1: (S)-1-(1-Naphthyl)ethanol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; Inert atmosphere; Stage #2: N,N-diisopropylcarbamoyl chloride In tetrahydrofuran; mineral oil at 20℃; for 48h; Inert atmosphere; | 98% |
With triethylamine In dichloromethane for 94h; Inert atmosphere; Reflux; | 1.61 g |
(S)-1-(1-Naphthyl)ethanol
(2,4-dinitro-phenyl)-hydrazine
1-acetonaphthone 2,4-dinitrophenylhydrazone
Conditions | Yield |
---|---|
Stage #1: (S)-1-(1-Naphthyl)ethanol With peracetic acid; C9H17NO5S(1-)*C12H11IN(1+); acetic acid In 1,1,1,3',3',3'-hexafluoro-propanol at 20℃; for 18h; Stage #2: (2,4-dinitro-phenyl)-hydrazine With sulfuric acid In diethyl ether; ethanol; water | 95% |
(S)-1-(1-Naphthyl)ethanol
(3S)-4-(1-methyl-1H-imidazolylcarbonyl)-3-(4-bromophenyl)butyric acid
(1'S,3S)-1'-naphthylethyl-4-(1-methyl-1H-imidazolylcarbonyl)-3-(4-bromophenyl)butyrate
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; Inert atmosphere; optical yield given as %de; | 92% |
(S)-1-(1-Naphthyl)ethanol
1'-naphthacetophenone
Conditions | Yield |
---|---|
With 2-azaadamantane-N-oxyl; oxygen In aq. acetate buffer at 20℃; for 8h; pH=4.5; Reagent/catalyst; Green chemistry; Enzymatic reaction; chemoselective reaction; | 92% |
(S)-1-(1-Naphthyl)ethanol
Conditions | Yield |
---|---|
With diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 0 - 20℃; for 18h; Inert atmosphere; | 92% |
(S)-1-(1-Naphthyl)ethanol
Conditions | Yield |
---|---|
With Na In neat (no solvent) naphthylethanol and Na were stirred under Ar at 100°C, finely powdered complex was added at 70°C, stirred for 30 min at 70°C and diminished pressure (1.5 kPa); dissolved in CH2Cl2, chromy. on silica gel column, hexane-CH2Cl2 1:1, asfoam, the mixt. of (S,S) and (R,S)-diastereomers; | 85% |
(S)-1-(1-Naphthyl)ethanol
(3S)-4-(1-methyl-1H-imidazolylcarbonyl)-3-phenylbutyric acid
(1'S,3S)-1'-naphthylethyl-4-(1-methyl-1H-imidazolylcarbonyl)-3-phenylbutyrate
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; Inert atmosphere; optical yield given as %de; | 85% |
(S)-1-(1-Naphthyl)ethanol
Conditions | Yield |
---|---|
With Na In neat (no solvent) naphthylethanol and Na were stirred under Ar at 100°C, finely powdered complex was added at 70°C, stirred for 30 min at 70°C and diminished pressure (1.5 kPa); dissolved in CH2Cl2, chromy. on silica gel column, hexane-CH2Cl2 1:1, asfoam, the mixt. of (S,S) and (R,S)-diastereomers; | 83% |
(S)-1-(1-Naphthyl)ethanol
Conditions | Yield |
---|---|
With Na In neat (no solvent) naphthylethanol and Na were stirred under Ar at 100°C, finely powdered complex was added at 70°C, stirred for 2 h at 70°C and diminished pressure (1.5 kPa); dissolved in CH2Cl2, chromy. on silica gel column, hexane-CH2Cl2 1:1, asfoam, the mixt. of (S,S) and (R,S)-diastereomers; | 83% |
(S)-1-(1-Naphthyl)ethanol
pivaloyl chloride
(S)-1-(naphthalen-1-yl)ethyl pivalate
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 20℃; for 12h; | 81% |
(S)-1-(1-Naphthyl)ethanol
(1S,5R,7S)-1,5,7-Trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carbonyl chloride
Conditions | Yield |
---|---|
70% |
(S)-1-(1-Naphthyl)ethanol
1-Phenyl-2-propyn-1-ol
Conditions | Yield |
---|---|
With ammonium tetrafluoroborate; [(Cp*)RuCl(SMe)]2 In 1,2-dichloro-ethane at 60℃; for 1h; | 64% |
4-carbethoxypiperidine
(S)-1-(1-Naphthyl)ethanol
Conditions | Yield |
---|---|
Stage #1: (S)-1-(1-Naphthyl)ethanol With N-ethyl-N,N-diisopropylamine; Methanesulfonic anhydride In dichloromethane at 0℃; for 0.666667h; Stage #2: 4-carbethoxypiperidine In dichloromethane at 20℃; for 16h; | 54% |
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