As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryHebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. After many years of efforts, we have established stable
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryWe are leading fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Orga
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inquiry1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;
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inquirytert-Butyl [(1S,2R)-1-Benzyl-2-hydroxy-3-(isobutylamino)propyl]carbamate CAS:160232-08-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical int
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:160232-08-6
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryChemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryProduct name: Tert-Butyl[(1S,2R)-1-Benzyl-2-Hydroxy-3-(Isobutylamino)propyl]carbamate CAS No.:160232-08-6 Molecule Formula:C19H32N2O3 Molecule Weight:336.47 Purity: 98.0% Package: 25kg/drum Description:Light yellow powder Manufacture
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inquiryhigh purity Application:Pharmaceutical intermediates
Cas:160232-08-6
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Type:Trading Company
inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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inquirySAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe
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inquiryLower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
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inquiry1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re
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inquiryJinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands
Cas:160232-08-6
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inquiryhigh quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea
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inquiryOur clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS
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inquiryTAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp
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inquiryKONING PHARMCHEM CO., LTD. has committed itself to a strategy of providing a unique service for companies involved in the manufacture of pharmaceuticals, healthcare products, food, cosmetics and other fine chemicals. Our products including but not li
Cas:160232-08-6
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquiryAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China
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inquiryisobutylamine
(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
In isopropyl alcohol at 20℃; | 100% |
In isopropyl alcohol at 60℃; for 6h; | 100% |
In isopropyl alcohol at 60℃; Inert atmosphere; | 100% |
isobutylamine
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol at 15 - 20℃; Large scale; | 97.3% |
With sodium carbonate In water at 60 - 65℃; for 3h; | 105 g |
With sodium carbonate In water at 60 - 65℃; for 3h; | 105 g |
isobutylamine
(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
In isopropyl alcohol at 20 - 30℃; Solvent; | 94.67% |
In isopropyl alcohol at 80℃; for 2.5h; | 93% |
In isopropyl alcohol at 80℃; for 2.5h; |
isobutyraldehyde
(1S,2R)-(3-amino-1-benzyl-2-hydroxy-propyl)-carbamic acid tert butyl ester
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
With sodium tris(acetoxy)borohydride In ethanol at 0 - 20℃; for 5h; Reagent/catalyst; | 81.6% |
With hydrogen; platinum(IV) oxide In methanol under 7600 Torr; for 2h; Ambient temperature; | 80% |
isobutylamine
(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane
B
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
In toluene at 20 - 30℃; Solvent; | A n/a B 80% |
isobutylamine
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
With 3S-(N-t-butoxycarbonyl)amino-2R-hydroxy-4-phenylbut-1-yl toluenesulfonate In isopropyl alcohol; toluene at 80 - 85℃; for 1.5h; | 76.8% |
C19H31N3O4
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
With hydrogen; nickel In tetrahydrofuran under 760 Torr; Ambient temperature; | 64% |
2(R)-((tert-butyloxycarbonyl)amino)-1,4-dichloro-3(S)-hydroxybutane
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: p-TsOH*H2O / CH2Cl2 2.1: NaH / tetrahydrofuran 3.1: CuBr*SMe2 / tetrahydrofuran 4.1: p-TsOH*H2O 4.2: KOH / methanol 5.1: 90 percent / propan-2-ol / 5 h / 50 °C View Scheme | |
Multi-step reaction with 5 steps 1: 100 percent / imidazole; DMAP / dimethylformamide / 12 h / 50 °C 2: 100 percent / NaH / tetrahydrofuran / 5 h / 0 °C 3: 75 percent / CuBr*Me2S / toluene; tetrahydrofuran / -78 - -20 °C 4: Bu4NF / tetrahydrofuran 5: 90 percent / propan-2-ol / 5 h / 50 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: 100 percent / imidazole; DMAP / dimethylformamide / 12 h / 50 °C 2.1: 100 percent / NaH / tetrahydrofuran / 5 h / 0 °C 3.1: 82 percent / Et3N / methanol / 18 h / 20 °C 4.1: TBAF / tetrahydrofuran / 0.67 h / 20 °C 4.2: 75 percent / KOH / methanol / 2 h / 20 °C 5.1: 90 percent / propan-2-ol / 5 h / 50 °C View Scheme |
N-t-butyloxycarbonyl-2(S)-(1(S)-t-butyldimethylsilyloxy-2-chloroethyl)aziridine
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 75 percent / CuBr*Me2S / toluene; tetrahydrofuran / -78 - -20 °C 2: Bu4NF / tetrahydrofuran 3: 90 percent / propan-2-ol / 5 h / 50 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: 82 percent / Et3N / methanol / 18 h / 20 °C 2.1: TBAF / tetrahydrofuran / 0.67 h / 20 °C 2.2: 75 percent / KOH / methanol / 2 h / 20 °C 3.1: 90 percent / propan-2-ol / 5 h / 50 °C View Scheme |
(S)-2-[(S)-2-Chloro-1-(tetrahydro-pyran-2-yloxy)-ethyl]-aziridine-1-carboxylic acid tert-butyl ester
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: CuBr*SMe2 / tetrahydrofuran 2.1: p-TsOH*H2O 2.2: KOH / methanol 3.1: 90 percent / propan-2-ol / 5 h / 50 °C View Scheme |
2(S)-t-butyldimethylsilyloxy-3(R)-(t-butyloxycarbonyl)amino-1,4-dichlorobutane
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 100 percent / NaH / tetrahydrofuran / 5 h / 0 °C 2: 75 percent / CuBr*Me2S / toluene; tetrahydrofuran / -78 - -20 °C 3: Bu4NF / tetrahydrofuran 4: 90 percent / propan-2-ol / 5 h / 50 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: 100 percent / NaH / tetrahydrofuran / 5 h / 0 °C 2.1: 82 percent / Et3N / methanol / 18 h / 20 °C 3.1: TBAF / tetrahydrofuran / 0.67 h / 20 °C 3.2: 75 percent / KOH / methanol / 2 h / 20 °C 4.1: 90 percent / propan-2-ol / 5 h / 50 °C View Scheme |
[(1R,2S)-3-Chloro-1-chloromethyl-2-(tetrahydro-pyran-2-yloxy)-propyl]-carbamic acid tert-butyl ester
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: NaH / tetrahydrofuran 2.1: CuBr*SMe2 / tetrahydrofuran 3.1: p-TsOH*H2O 3.2: KOH / methanol 4.1: 90 percent / propan-2-ol / 5 h / 50 °C View Scheme |
[(1S,2S)-1-Benzyl-3-chloro-2-(tetrahydro-pyran-2-yloxy)-propyl]-carbamic acid tert-butyl ester
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: p-TsOH*H2O 1.2: KOH / methanol 2.1: 90 percent / propan-2-ol / 5 h / 50 °C View Scheme |
2(S)-t-butyldimethylsilyloxy-3(S)-(t-butyloxycarbonyl)amino-1-chloro-4-phenylbutane
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Bu4NF / tetrahydrofuran 2: 90 percent / propan-2-ol / 5 h / 50 °C View Scheme |
(3S)-t-butyldimethylsilyloxy-(2R)-(t-butyloxycarbonyl)amino-4-chloro-1-phenylthiobutane
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: TBAF / tetrahydrofuran / 0.67 h / 20 °C 1.2: 75 percent / KOH / methanol / 2 h / 20 °C 2.1: 90 percent / propan-2-ol / 5 h / 50 °C View Scheme |
(2S,3S)-3-Amino-1-benzyloxy-4-phenyl-butan-2-ol
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: CH2Cl2 / 3 h / 23 °C 2: 356 mg / H2 / Pd(OH)2 / ethyl acetate; methanol / 12 h 3: 61 percent / PPh3, DEAD / CHCl3 / 72 h / Heating 4: propan-2-ol / 3.5 h / 68 °C View Scheme |
(4S,5S)-4-benzyl-5-benzyloxymethyl-1,3-oxazolidin-2-one
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: KOH / ethanol; H2O / 17 h / Heating 2: CH2Cl2 / 3 h / 23 °C 3: 356 mg / H2 / Pd(OH)2 / ethyl acetate; methanol / 12 h 4: 61 percent / PPh3, DEAD / CHCl3 / 72 h / Heating 5: propan-2-ol / 3.5 h / 68 °C View Scheme |
((1S,2S)-1-Benzyl-3-benzyloxy-2-hydroxy-propyl)-carbamic acid tert-butyl ester
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 356 mg / H2 / Pd(OH)2 / ethyl acetate; methanol / 12 h 2: 61 percent / PPh3, DEAD / CHCl3 / 72 h / Heating 3: propan-2-ol / 3.5 h / 68 °C View Scheme |
di-tert-butyl dicarbonate
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: CH2Cl2 / 3 h / 23 °C 2: 356 mg / H2 / Pd(OH)2 / ethyl acetate; methanol / 12 h 3: 61 percent / PPh3, DEAD / CHCl3 / 72 h / Heating 4: propan-2-ol / 3.5 h / 68 °C View Scheme |
(2S,3S)-3-(t-butoxycarbonylamino)-4-phenylbutane-1,2-diol
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 61 percent / PPh3, DEAD / CHCl3 / 72 h / Heating 2: propan-2-ol / 3.5 h / 68 °C View Scheme |
N-tert-butoxycarbonyl-L-phenylalanine
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) CDI, 2.) t-BuOK / 1.) THF, room temperature, 2 h, 2.) THF, room temperature, 15 h 2: 69 percent / NaBH4 / methanol; tetrahydrofuran / 1 h / 0 °C 3: 89 percent / H2 / Raney Ni / methanol / 17 h / 35 °C / 30400 Torr 4: 80 percent / H2 / PtO2 / methanol / 2 h / 7600 Torr / Ambient temperature View Scheme | |
Multi-step reaction with 3 steps 1: 1.) CDI, 2.) t-BuOK / 1.) THF, room temperature, 2 h, 2.) THF, room temperature, 15 h 2: NaBH4, TiCl4 / 1,2-dimethoxy-ethane / 1 h / -5 °C 3: 80 percent / H2 / PtO2 / methanol / 2 h / 7600 Torr / Ambient temperature View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine 2: aluminum sec-butoxide / toluene; 2-methyl-propan-1-ol / 15 - 20 °C / Large scale 3: potassium hydroxide / ethanol / 15 - 20 °C / Large scale View Scheme | |
Multi-step reaction with 5 steps 1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 5 h / 20 °C 2.1: potassium hydroxide / N,N-dimethyl-formamide / 1 h / 10 - 25 °C 2.2: 20 - 25 °C 3.1: aluminum tri-tert-butoxide / isopropyl alcohol / 2 h / 60 - 65 °C 4.1: 5%-palladium/activated carbon; hydrogen / ethanol / 5 h / 30 - 40 °C / 3800.26 Torr 5.1: sodium tris(acetoxy)borohydride / ethanol / 5 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 5 h / 20 °C 2.1: potassium tert-butylate / dimethyl sulfoxide / 1 h / 10 - 25 °C 2.2: 20 - 25 °C 3.1: aluminum tri-tert-butoxide / isopropyl alcohol / 2 h / 60 - 65 °C 4.1: 5%-palladium/activated carbon; hydrogen / ethanol / 5 h / 30 - 40 °C / 3800.26 Torr 5.1: sodium tris(acetoxy)borohydride / ethanol / 5 h / 0 - 20 °C View Scheme |
(2S,3R)-N-tert-butyloxycarbonyl-2-amino-3-hydroxy-1-phenyl-4-nitrobutane
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 89 percent / H2 / Raney Ni / methanol / 17 h / 35 °C / 30400 Torr 2: 80 percent / H2 / PtO2 / methanol / 2 h / 7600 Torr / Ambient temperature View Scheme |
(S)-3-tert-butoxycarbonylamino-1-nitro-4-phenyl-2-butanone
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 69 percent / NaBH4 / methanol; tetrahydrofuran / 1 h / 0 °C 2: 89 percent / H2 / Raney Ni / methanol / 17 h / 35 °C / 30400 Torr 3: 80 percent / H2 / PtO2 / methanol / 2 h / 7600 Torr / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: NaBH4, TiCl4 / 1,2-dimethoxy-ethane / 1 h / -5 °C 2: 80 percent / H2 / PtO2 / methanol / 2 h / 7600 Torr / Ambient temperature View Scheme | |
Multi-step reaction with 3 steps 1: aluminum tri-tert-butoxide / isopropyl alcohol / 2 h / 60 - 65 °C 2: 5%-palladium/activated carbon; hydrogen / ethanol / 5 h / 30 - 40 °C / 3800.26 Torr 3: sodium tris(acetoxy)borohydride / ethanol / 5 h / 0 - 20 °C View Scheme |
N-nitroso-N-methylisobutylamine
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 66 percent / LDA / tetrahydrofuran / -78 °C 2: 89 percent / H2 / 20percent Pd(OH)2/C / ethyl acetate / 760 Torr / Ambient temperature 3: 64 percent / H2 / Raney nickel / tetrahydrofuran / 760 Torr / Ambient temperature View Scheme |
(2S)-N,N-dibenzylphenylalaninal
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 66 percent / LDA / tetrahydrofuran / -78 °C 2: 89 percent / H2 / 20percent Pd(OH)2/C / ethyl acetate / 760 Torr / Ambient temperature 3: 64 percent / H2 / Raney nickel / tetrahydrofuran / 760 Torr / Ambient temperature View Scheme | |
Multi-step reaction with 5 steps 1: lithium / tetrahydrofuran / 3 h / -65 °C / Inert atmosphere 2: palladium hydroxide on carbon; hydrogen / methanol / 4 h / 20 °C / 760.05 Torr 3: triethylamine / tetrahydrofuran / 20 °C / Cooling with ice 4: potassium hydroxide / tetrahydrofuran; methanol / Cooling with ice 5: ethanol / 1 h / 78 °C / Inert atmosphere View Scheme |
C28H35N3O2
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 89 percent / H2 / 20percent Pd(OH)2/C / ethyl acetate / 760 Torr / Ambient temperature 2: 64 percent / H2 / Raney nickel / tetrahydrofuran / 760 Torr / Ambient temperature View Scheme |
isopropylamine
(1S,2R)-(3-amino-1-benzyl-2-hydroxy-propyl)-carbamic acid tert butyl ester
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
In ethanol at 85℃; for 72h; | 0.56 g |
isobutylamine
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
In ethanol for 1h; Heating / reflux; |
4-Nitrobenzenesulfonyl chloride
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In dichloromethane; water at 20℃; for 21h; | 100% |
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 25℃; for 4h; | 98.2% |
With sodium hydrogencarbonate In dichloromethane; water at 23℃; for 12h; | 96% |
benzyl chloroformate
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl](2-methylpropyl)carbamic acid phenylmethyl ester
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at -1.5 - 20℃; for 48h; | 100% |
Stage #1: benzyl chloroformate; (2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol With triethylamine In dichloromethane at -1.5 - 20℃; for 48h; Stage #2: With sodium carbonate In dichloromethane; water for 0.166667h; | 100% |
With sodium carbonate In tetrahydrofuran at 5 - 10℃; for 3h; | 77% |
benzothiazole-6-carboxylic acid
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
tert-butyl (2S,3R)-3-hydroxy-4-(N-isobutylbenzo[d]thiazole-6-carboxamido)-1-phenylbutan-2-ylcarbamate
Conditions | Yield |
---|---|
With triethylamine; HATU In dichloromethane at 20℃; | 100% |
3-methyl-1H-indazole-5-sulfonyl chloride
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
{1-benzyl-2-hydroxy-3-[isobutyl-(3-methyl-1H-indazole-5-sulfonyl)-amino]-propyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In dichloromethane; water | 99% |
4-trifluorophenylsulfonyl chloride
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 25℃; for 4h; | 98.4% |
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃; Inert atmosphere; Sealed tube; |
4-Acetylbenzenesulfonyl chloride
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
tert-butyl ((2S,3R)-4-((4-acetyl-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
With sodium carbonate In water; ethyl acetate at 20℃; for 18h; Inert atmosphere; | 98% |
With triethylamine In dichloromethane |
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
(2R,3S)-3-amino-1-(isobutylamino)-4-phenyl-2-butanol
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane for 5h; | 98% |
4-methoxy-phenyl-sulphonyl chloride
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
tert-butyl (1S,2R)-1-benzyl-2-hydroxy-3-{isobutyl[(4-methoxyphenyl)sulfonyl]amino}propylcarbamate
Conditions | Yield |
---|---|
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 25℃; for 4h; | 97.7% |
With sodium hydrogencarbonate In dichloromethane; water at 23℃; for 16h; | 83% |
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 30℃; for 0.5h; Cooling with ice; | 82% |
1-benzofuran-5-sulfonyl chloride
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
C27H36N2O6S
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 2.5h; | 92% |
With triethylamine In dichloromethane at 20℃; for 2.5h; | 92% |
With triethylamine In dichloromethane at 20℃; for 2.5h; | 92% |
With triethylamine In dichloromethane at 20℃; for 2.5h; | 92% |
p-acetylaminobenzenesulfonyl chloride
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl-(4-acetylaminobenzenesulfonyl amino)propyl]carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl acetamide at 25 - 35℃; for 2h; | 90.56% |
With triethylamine In dichloromethane at 0 - 30℃; for 1h; Concentration; Solvent; | 86.8% |
With sodium hydrogencarbonate In dichloromethane; water for 14h; | 714.4 mg |
In dichloromethane; water at 10 - 30℃; for 1h; Time; |
4-(trifluoro-methoxy)benzene-1-sulfonyl chloride
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
N-[(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[[(4-trifluoromethoxy)phenyl]sulfonyl]amino]propyl]carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃; | 89.7% |
With sodium carbonate In dichloromethane at 0 - 20℃; |
(4-(chlorosulfonyl)phenyl)methylene diacetate
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
(acetyloxy)(4-{[{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}(isobutyl)amino]sulfonyl}phenyl)methyl Acetate
Conditions | Yield |
---|---|
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 23℃; for 4h; | 88% |
With triethylamine In tetrahydrofuran at 20℃; for 4h; | |
With triethylamine In tetrahydrofuran at 25℃; for 4h; | |
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃; |
1-acetyl-2,3-dihydro-1H-indole-5-sulfonyl chloride
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
((2S,3R)-4-(1-acetyl-N-isobutylindoline-5-sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In dichloromethane | 86% |
4-bromobenzenesulfonyl chloride
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0℃; for 16h; Inert atmosphere; | 86% |
methyl N-[5-(chlorosulfonyl)-1H-benzimidazol-2-yl]carbamate
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 5h; | 85% |
4-(methylsulfanyl)benzenesulfonyl chloride
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 25℃; | 85% |
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 23℃; for 1h; Inert atmosphere; | 82% |
benzo[1,3]dioxol-5-sulfonyl chloride
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
N-[(1S,2R)-3-[[(benzo-[1,3]-dioxole-5-sulfonyl)](isobutyl)amino]-1-benzyl-2-hydroxypropyl]carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 4h; | 81% |
With N-ethyl-N,N-diisopropylamine; dmap In tetrahydrofuran at 20℃; for 4h; | 81% |
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃; | 71.2% |
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
6-methoxypyridin-3-ylsulfonyl chloride
Conditions | Yield |
---|---|
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 25℃; | 80% |
4-vinylbenzenesulfonyl chloride
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
tert-butyl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-vinylphenylsulfonamido)-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
With sodium carbonate In water; ethyl acetate at 20℃; for 18h; Inert atmosphere; | 77% |
With triethylamine In dichloromethane at 25℃; for 3h; | 54% |
(fluorenylmethoxy)carbonyl chloride
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
C34H42N2O5
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 1h; | 76% |
3,4-dimethoxybenzene-1-sulfonyl chloride
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃; | 65.3% |
With sodium hydrogencarbonate In dichloromethane; water for 14h; | |
With triethylamine In dichloromethane at 20℃; for 24h; Inert atmosphere; |
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