Dayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantiti
Cas:165727-45-7
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:165727-45-7
Min.Order:0 Metric Ton
Negotiable
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:165727-45-7
Min.Order:1
Negotiable
Type:Other
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:165727-45-7
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:165727-45-7
Min.Order:1 Kilogram
FOB Price: $100.0 / 150.0
Type:Trading Company
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:165727-45-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:165727-45-7
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:165727-45-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;
Cas:165727-45-7
Min.Order:0 Metric Ton
Negotiable
Type:Trading Company
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:165727-45-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:165727-45-7
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Negotiable
Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Cas:165727-45-7
Min.Order:0
Negotiable
Type:Manufacturers
inquiryAppearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:packaged in foil bags or tins Application:Use only for laboratory research Transportation:Sea,Air,DHL/TNT/FEdex/UPS/EMS Por
Cas:165727-45-7
Min.Order:10 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryWe are concentrating on the R&D and technical service of APIs and pharmaceutical intermediates Application:Pharmaceutical intermediate Port:Chinese main port
Cas:165727-45-7
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:165727-45-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry(1S, 2S)-(1-benzyl-3-chloro-2-hydroxy-propyl)-carbamic acid tert-butyl esterAppearance:White crystal Storage:IN SHADE Package:according to customers' requirements Application:chemical research Transportation:By air(EMS or EUB or FedEx or TNT ect...)
Cas:165727-45-7
Min.Order:1 Gram
Negotiable
Type:Other
inquiryProduct name: (3S)-3-(Tert-Butoxycarbonyl)Amino-1-Chloro-4-Phenyl-(2S)-Butanol CAS No.:165727-45-7 Molecule Formula:C15H22ClNO3 Molecule Weight:299.79 Purity: 99.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards
Cas:165727-45-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:165727-45-7
Min.Order:1 Metric Ton
FOB Price: $7.0 / 8.0
Type:Trading Company
inquiryLocated in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h
Cas:165727-45-7
Min.Order:0
Negotiable
Type:Other
inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
Cas:165727-45-7
Min.Order:0
Negotiable
Type:Manufacturers
inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
Cas:165727-45-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquirySAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe
Cas:165727-45-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
Cas:165727-45-7
Min.Order:0
Negotiable
Type:Trading Company
inquiryLower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
Cas:165727-45-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryShanghai Lonwin Chemical company is a subsidiary of Lonwin Industry Group Limited, was established in 2011 and is headquartered in Shanghai, adjacent to China National Convention and Exhibition Center and Hongqiao transportation hub.Lonwinchem is
Cas:165727-45-7
Min.Order:100 Kilogram
FOB Price: $100.0 / 150.0
Type:Other
inquiryJinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands
Cas:165727-45-7
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryR & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates
Cas:165727-45-7
Min.Order:0
Negotiable
Type:Manufacturers
inquiryQ1: Are you a manufacturer Answer: Yes, we are factory founded on 2012.Q2: How to contact with us Click "contact supplier" And then send us message the product you interest in, you will get reply within 12 hours.Q3:Which kind of payment terms do you
Cas:165727-45-7
Min.Order:0
Negotiable
Type:Trading Company
inquiryhigh quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea
Cas:165727-45-7
Min.Order:0
Negotiable
Type:Manufacturers
inquiryOur clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS
Cas:165727-45-7
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Negotiable
Type:Manufacturers
inquiry(S)-tert-butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
With isopropyl alcohol; aluminum tri-tert-butoxide In dichloromethane at 50℃; Product distribution / selectivity; Meerwein-Ponndorf-Verley Reduction; Inert atmosphere; | 95% |
With aluminum sec-butoxide In 2-methyl-propan-1-ol; toluene at 15 - 20℃; Large scale; | 95% |
With C38H40ClN2O3RhS In dichloromethane at 25℃; for 1h; Catalytic behavior; Schlenk technique; diastereoselective reaction; | 93% |
(S)-tert-butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate
isopropyl alcohol
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
With diisobutylaluminium hydride In toluene | 90% |
(S)-tert-butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate
A
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
B
(2R,3S)-1-Chloro-2-hydroxy-3-N-(tert-butoxycarbonyl)amino-4-phenylbutane
D
(1R,2S)[3-chloro-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid 1,1-dimethylethyl ester
Conditions | Yield |
---|---|
With potassium phosphate buffer; Streptomyces nodosus SC 13149 at 28℃; for 48h; pH=6.8; microbial reduction; | A 62% B n/a C n/a D n/a |
(S)-tert-butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate
A
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
B
(2R,3S)-1-Chloro-2-hydroxy-3-N-(tert-butoxycarbonyl)amino-4-phenylbutane
Conditions | Yield |
---|---|
With sodium tetrahydroborate In tetrahydrofuran; water at 0℃; for 0.75h; | A 50% B n/a |
With sodium tetrahydroborate In tetrahydrofuran; water at 0℃; for 0.75h; | A n/a B 50% |
With sodium tetrahydroborate In ethanol; toluene at -78 - 0℃; for 8h; | A 7.8 g B n/a |
(S)-tert-butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
With sodium borohydrid In tetrahydrofuran; water; ethyl acetate | 50% |
di-tert-butyl dicarbonate
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
With triethylamine | |
With triethylamine In tetrahydrofuran at 20℃; Cooling with ice; |
(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: LDA / tetrahydrofuran / 0.5 h / -78 °C 2: 7.8 g / NaBH4 / toluene; ethanol / 8 h / -78 - 0 °C View Scheme |
N-t-butoxycarbonyl-L-phenylalanine 4-nitrophenyl ester
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: t-BuOK / tetrahydrofuran / 2 h / Heating 1.2: tetrahydrofuran / 4 h / 0 °C 2.1: 81 percent / LiCl; MeSO3H / tetrahydrofuran / 2 h / 70 °C 3.1: 50 percent / NaBH4 / tetrahydrofuran; H2O / 0.75 h / 0 °C View Scheme |
tert-butyl (S)-(4-(dimethyl(oxo)-λ6-sulfanylidene)-3-oxo-1-phenylbutan-2-yl)carbamate
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 81 percent / LiCl; MeSO3H / tetrahydrofuran / 2 h / 70 °C 2: 50 percent / NaBH4 / tetrahydrofuran; H2O / 0.75 h / 0 °C View Scheme |
(2S)-N,N-dibenzylphenylalaninal
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Li / tetrahydrofuran / -55 °C 2: 97 percent / H2 / Pd(OH)2/C / 760 Torr 3: Et3N View Scheme | |
Multi-step reaction with 3 steps 1: lithium / tetrahydrofuran / 3 h / -65 °C / Inert atmosphere 2: palladium hydroxide on carbon; hydrogen / methanol / 4 h / 20 °C / 760.05 Torr 3: triethylamine / tetrahydrofuran / 20 °C / Cooling with ice View Scheme |
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 97 percent / H2 / Pd(OH)2/C / 760 Torr 2: Et3N View Scheme | |
Multi-step reaction with 2 steps 1: palladium hydroxide on carbon; hydrogen / methanol / 4 h / 20 °C / 760.05 Torr 2: triethylamine / tetrahydrofuran / 20 °C / Cooling with ice View Scheme |
(S)-2-(dibenzylamino)-3-phenylpropan-1-ol
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 99 percent / pyridine*SO3, DMSO, Et3N / 10 °C 2: Li / tetrahydrofuran / -55 °C 3: 97 percent / H2 / Pd(OH)2/C / 760 Torr 4: Et3N View Scheme | |
Multi-step reaction with 4 steps 1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 1.08 h / 15 °C / Cooling with ice 2: lithium / tetrahydrofuran / 3 h / -65 °C / Inert atmosphere 3: palladium hydroxide on carbon; hydrogen / methanol / 4 h / 20 °C / 760.05 Torr 4: triethylamine / tetrahydrofuran / 20 °C / Cooling with ice View Scheme |
N-tert-butoxycarbonyl-L-phenylalanine
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 4-methylmorpholine / tetrahydrofuran / 0.33 h / -25 - -20 °C 2: diethyl ether / a) 0 deg C, 2 h, b) RT, overnight 3: 92 percent / HCl / dioxane; diethyl ether / 1 h / 0 °C 4: NaBH4 / tetrahydrofuran; H2O / 0.75 h / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1: triethylamine 2: aluminum sec-butoxide / toluene; 2-methyl-propan-1-ol / 15 - 20 °C / Large scale View Scheme |
(3S)-tert-butyl 1-benzyl-3-diazo-2-oxopropylcarbamate
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 92 percent / HCl / dioxane; diethyl ether / 1 h / 0 °C 2: NaBH4 / tetrahydrofuran; H2O / 0.75 h / 0 °C View Scheme |
Boc-Phe-O-COO-isoBu
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: diethyl ether / a) 0 deg C, 2 h, b) RT, overnight 2: 92 percent / HCl / dioxane; diethyl ether / 1 h / 0 °C 3: NaBH4 / tetrahydrofuran; H2O / 0.75 h / 0 °C View Scheme |
triisobutylaluminum
(S)-tert-butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate
isopropyl alcohol
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
In hexane; toluene |
Triisopropyl borate
triisobutylaluminum
(S)-tert-butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
In hexane; toluene |
diethyl(ethoxy)aluminum
(S)-tert-butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
With hydrogenchloride In toluene |
1,1-Diphenylmethanol
triisobutylaluminum
(S)-tert-butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
With methanesulfonic acid In hexane; toluene |
(2S,3R)-2-amino-4-chloro-1-phenylbutan-3-ol hydrochloride
di-tert-butyl dicarbonate
A
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
B
(2R,3S)-1-Chloro-2-hydroxy-3-N-(tert-butoxycarbonyl)amino-4-phenylbutane
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; water; toluene at 25℃; for 3h; pH=7; Product distribution / selectivity; |
L-phenylalanine
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: sodium tetrahydroborate; iodine / tetrahydrofuran / Cooling with ice; Reflux 2.1: potassium carbonate / methanol; water / 0.17 h / Reflux 2.2: 1 h / Heating 3.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 1.08 h / 15 °C / Cooling with ice 4.1: lithium / tetrahydrofuran / 3 h / -65 °C / Inert atmosphere 5.1: palladium hydroxide on carbon; hydrogen / methanol / 4 h / 20 °C / 760.05 Torr 6.1: triethylamine / tetrahydrofuran / 20 °C / Cooling with ice View Scheme |
L-Phenylalaninol
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: potassium carbonate / methanol; water / 0.17 h / Reflux 1.2: 1 h / Heating 2.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 1.08 h / 15 °C / Cooling with ice 3.1: lithium / tetrahydrofuran / 3 h / -65 °C / Inert atmosphere 4.1: palladium hydroxide on carbon; hydrogen / methanol / 4 h / 20 °C / 760.05 Torr 5.1: triethylamine / tetrahydrofuran / 20 °C / Cooling with ice View Scheme |
C15H20N3O3(1+)
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride 2: aluminum isopropoxide / isopropyl alcohol / 3 h / Reflux View Scheme |
(S)-3-(tert-butoxycarbonyl)amino-4-phenyl-2-butanone
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / ethyl acetate; water / 2.5 h / 20 °C 2: sodium carbonate; hydrogen; C44H48FeIrNO2P(1+)*C32H12BF24(1-) / methanol / 2 h / 20 °C View Scheme |
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With potassium carbonate In methanol | 100% |
With potassium tert-butylate In tetrahydrofuran; isopropyl alcohol at 16℃; for 0.5h; | 96% |
With potassium carbonate; citric acid In ethanol; n-heptane; water; toluene | 95% |
methanesulfonyl chloride
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
With triethylamine In toluene at 35℃; for 2h; Temperature; Inert atmosphere; | 99.1% |
isobutylamine
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol at 15 - 20℃; Large scale; | 97.3% |
With sodium carbonate In water at 60 - 65℃; for 3h; | 105 g |
With sodium carbonate In water at 60 - 65℃; for 3h; | 105 g |
isopropyl alcohol
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
citric acid
(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With sodium hydroxide In water | 87% |
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; ethanol at 0 - 20℃; for 4.5h; Time; | 74% |
Multi-step reaction with 3 steps 1: thionyl chloride / tert-butyl methyl ether / 8 h / 10 - 55 °C 2: triethylamine; dmap / tert-butyl methyl ether / 8 h / 10 - 20 °C 3: potassium hydroxide / ethanol / 0.5 h / 5 °C View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / toluene / 2 h / 35 °C / Inert atmosphere 2: 18-crown-6 ether / toluene / 3 h / 70 °C 3: potassium hydroxide / tetrahydrofuran; ethanol / 2 h / -15 °C / Inert atmosphere View Scheme |
tetrabutylammonium acetate
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
(2S, 3S)-1-acetoxy-3-(t-butoxycarbonylamino)-2-hydroxy-4-phenylbutane
Conditions | Yield |
---|---|
In acetonitrile for 18h; Heating / reflux; | 70% |
In methanol; water; ethyl acetate; acetonitrile |
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
(4R)-4-{1-[(S)-(tert-butoxycarbonyl)amino]-2-phenylethyl}-γ-butyrolactone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 89 percent / KOH / ethanol / 2 h / 20 °C 2: 90 percent / EtONa / ethanol / 20 °C 3: LiOH / dimethylformamide; H2O / 6 h / 50 °C 4: toluene / 5 h / Heating View Scheme |
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
3-carbethoxy-5(R)-<1'-(S)-<(tert-butyloxycarbonyl)amino>-2-phenylethyl>dihydrofuran-2(3H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 89 percent / KOH / ethanol / 2 h / 20 °C 2: 90 percent / EtONa / ethanol / 20 °C View Scheme |
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 89 percent / KOH / ethanol / 2 h / 20 °C 2: 90 percent / EtONa / ethanol / 20 °C 3: LiOH / dimethylformamide; H2O / 6 h / 50 °C View Scheme |
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: 89 percent / KOH / ethanol / 2 h / 20 °C 2.1: 90 percent / EtONa / ethanol / 20 °C 3.1: LiOH / dimethylformamide; H2O / 6 h / 50 °C 4.1: toluene / 5 h / Heating 5.1: LDA / tetrahydrofuran / 0.5 h / -78 °C 5.2: tetrahydrofuran / 0.5 h / -78 °C 5.3: 80 percent / Ac2O; Et3N / 1 h / 120 °C 6.1: H2 / Pd/C / ethyl acetate / 24 h / 20 °C View Scheme |
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
tert-butyl (S)-(1-((R)-4-(2-phenyl-1,3-dioxolan-2-yl)benzylidene)-tetrahydro-5-oxofuran-2-yl)-2-phenylethylcarbamate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 89 percent / KOH / ethanol / 2 h / 20 °C 2.1: 90 percent / EtONa / ethanol / 20 °C 3.1: LiOH / dimethylformamide; H2O / 6 h / 50 °C 4.1: toluene / 5 h / Heating 5.1: LDA / tetrahydrofuran / 0.5 h / -78 °C 5.2: tetrahydrofuran / 0.5 h / -78 °C 5.3: 80 percent / Ac2O; Et3N / 1 h / 120 °C View Scheme |
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
tert-butyl (S)-(1-((2R,4R)-4-(2-phenyl-1,3-dioxolan-2-yl)benzyl)-tetrahydro-5-oxofuran-2-yl)-2-phenylethylcarbamate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: 89 percent / KOH / ethanol / 2 h / 20 °C 2.1: 90 percent / EtONa / ethanol / 20 °C 3.1: LiOH / dimethylformamide; H2O / 6 h / 50 °C 4.1: toluene / 5 h / Heating 5.1: LDA / tetrahydrofuran / 0.5 h / -78 °C 5.2: tetrahydrofuran / 0.5 h / -78 °C 5.3: 80 percent / Ac2O; Et3N / 1 h / 120 °C 6.1: 90 percent / H2 / PtO2 / ethyl acetate / 2 h / 20 °C View Scheme |
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
(2R,4R,5S)-5-tert-Butoxycarbonylamino-4-hydroxy-6-phenyl-2-[4-(2-phenyl-[1,3]dioxolan-2-yl)-benzyl]-hexanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: 89 percent / KOH / ethanol / 2 h / 20 °C 2.1: 90 percent / EtONa / ethanol / 20 °C 3.1: LiOH / dimethylformamide; H2O / 6 h / 50 °C 4.1: toluene / 5 h / Heating 5.1: LDA / tetrahydrofuran / 0.5 h / -78 °C 5.2: tetrahydrofuran / 0.5 h / -78 °C 5.3: 80 percent / Ac2O; Et3N / 1 h / 120 °C 6.1: 90 percent / H2 / PtO2 / ethyl acetate / 2 h / 20 °C 7.1: LiOH / dimethylformamide; H2O / 20 °C View Scheme |
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
5(S)-tert-butoxycarbonylamino-4(R)-(tert-butyldimethylsilanyloxy)-6-phenyl-2-(4-(2-phenyl-1,3-dioxolan-2-yl)-benzyl)hexanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: 89 percent / KOH / ethanol / 2 h / 20 °C 2.1: 90 percent / EtONa / ethanol / 20 °C 3.1: LiOH / dimethylformamide; H2O / 6 h / 50 °C 4.1: toluene / 5 h / Heating 5.1: LDA / tetrahydrofuran / 0.5 h / -78 °C 5.2: tetrahydrofuran / 0.5 h / -78 °C 5.3: 80 percent / Ac2O; Et3N / 1 h / 120 °C 6.1: 90 percent / H2 / PtO2 / ethyl acetate / 2 h / 20 °C 7.1: LiOH / dimethylformamide; H2O / 20 °C 8.1: imidazole / dimethylformamide / 20 °C 8.2: MeOH / dimethylformamide / 2 h View Scheme |
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
{1S-benzyl-4R-[1-(1S-carbamoyl-2-phenyl-ethylcarbamoyl)-3-(1S)-methyl-butylcarbamoyl]-2R-hydroxy-5-[4-(2-phenyl-[1.3]dioxolan-2-yl)phenyl]-pentyl}carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: 89 percent / KOH / ethanol / 2 h / 20 °C 2.1: 90 percent / EtONa / ethanol / 20 °C 3.1: LiOH / dimethylformamide; H2O / 6 h / 50 °C 4.1: toluene / 5 h / Heating 5.1: LDA / tetrahydrofuran / 0.5 h / -78 °C 5.2: tetrahydrofuran / 0.5 h / -78 °C 5.3: 80 percent / Ac2O; Et3N / 1 h / 120 °C 6.1: 90 percent / H2 / PtO2 / ethyl acetate / 2 h / 20 °C 7.1: LiOH / dimethylformamide; H2O / 20 °C 8.1: imidazole / dimethylformamide / 20 °C 8.2: MeOH / dimethylformamide / 2 h 9.1: 88 percent / 1-(dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; Hunig's base / dimethylformamide / 20 °C 10.1: 71 percent / tetrabutylammonium fluoride / tetrahydrofuran / 20 °C View Scheme |
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
{1S-benzyl-2R-(tert-butyldimethylsilanyloxy)-4R-[1-(1S-carbamoyl-2-phenyl-ethylcarbamoyl)-3-(1S)-methyl-butylcarbamoyl]-5-[4-(2-phenyl-[1.3]dioxolan-2-yl)phenyl]-pentyl}carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: 89 percent / KOH / ethanol / 2 h / 20 °C 2.1: 90 percent / EtONa / ethanol / 20 °C 3.1: LiOH / dimethylformamide; H2O / 6 h / 50 °C 4.1: toluene / 5 h / Heating 5.1: LDA / tetrahydrofuran / 0.5 h / -78 °C 5.2: tetrahydrofuran / 0.5 h / -78 °C 5.3: 80 percent / Ac2O; Et3N / 1 h / 120 °C 6.1: 90 percent / H2 / PtO2 / ethyl acetate / 2 h / 20 °C 7.1: LiOH / dimethylformamide; H2O / 20 °C 8.1: imidazole / dimethylformamide / 20 °C 8.2: MeOH / dimethylformamide / 2 h 9.1: 88 percent / 1-(dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; Hunig's base / dimethylformamide / 20 °C View Scheme |
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: KOH / methanol 2: 1.) basic alumina, 2.) conc. HCl / 1.) THF, 45-50 deg C, 23 h, 2.) H2O, 1 h View Scheme |
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
(2S,4R)-1-((2R,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-4-(pyridin-4-ylmethoxy)-piperidine-2-carboxylic acid tert-butylamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: KOH / methanol 2: 1.) basic alumina, 2.) conc. HCl / 1.) THF, 45-50 deg C, 23 h, 2.) H2O, 1 h View Scheme |
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: KOH / methanol 2: basic alumina / tetrahydrofuran / 50 °C View Scheme |
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