Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:163521-12-8
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:163521-12-8
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:163521-12-8
Min.Order:1
Negotiable
Type:Other
inquiryOur advantage: 1: High quality and Competitive price 2: Quality control, GC&HPLC&NMR or as your requested 3: Packing as your requested, and double check before shipment 4: Prompt shipment with professional documents 5: Excellent after-
Cas:163521-12-8
Min.Order:1 Kilogram
FOB Price: $1.0 / 3.0
Type:Trading Company
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
Cas:163521-12-8
Min.Order:1 Kilogram
FOB Price: $0.9 / 1.0
Type:Lab/Research institutions
inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:163521-12-8
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:163521-12-8
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:163521-12-8
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryHubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy.
Cas:163521-12-8
Min.Order:10 Gram
FOB Price: $1500.0 / 2000.0
Type:Other
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:Store in dry、da
Cas:163521-12-8
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryVILAZODONE CAS:163521-12-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates
Cas:163521-12-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:163521-12-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi
Cas:163521-12-8
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:163521-12-8
Min.Order:1 Gram
Negotiable
Type:Other
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:163521-12-8
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:163521-12-8
Min.Order:1 Kilogram
FOB Price: $1.0 / 100000.0
Type:Lab/Research institutions
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:163521-12-8
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:163521-12-8
Min.Order:100 Milligram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
VILAZODONE cas 163521-12-8 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control syst
Cas:163521-12-8
Min.Order:1 Kilogram
FOB Price: $10.0 / 50.0
Type:Trading Company
inquiryPacking: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd
advantage: 1. The best price, satisfactory quality; 2. customers have the right to choose the delivery of parcels (EMS, DHL, FedEx, UPS); 3. customers have the right to choose from the recent effective packaging methods of their products packaging
Cas:163521-12-8
Min.Order:1 Gram
Negotiable
Type:Other
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:163521-12-8
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry1. We can provide customers with "one-stop"packaging service,from research,development,production,export and so on 2. Powerful R&D strength let our technology in a leading level,forever,in turn,to provide customers with better service .
Cas:163521-12-8
Min.Order:100 Gram
FOB Price: $10.0 / 100.0
Type:Trading Company
inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:163521-12-8
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:163521-12-8
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:163521-12-8
Min.Order:100 Gram
FOB Price: $100.0 / 2000.0
Type:Lab/Research institutions
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
methyl 5-{4-[4-(5-cyano-1H-indol-3-yl)-butyl]-piperazin-1-yl}-benzofuran-2-carboxylate
vilazodone
Conditions | Yield |
---|---|
With ammonia In methanol at 25 - 30℃; Concentration; Pressure; Time; | 98.5% |
With ammonia In methanol at 20℃; for 20h; | Ca. 3 g |
With ammonia In methanol at 25 - 30℃; | 11g |
3-(4-chlorobutyl)-5-cyanoindole
5-(1-piperazinyl)benzofuran-2-carboxamide
vilazodone
Conditions | Yield |
---|---|
Stage #1: 3-(4-chlorobutyl)-5-cyanoindole With sodium iodide In N,N-dimethyl-formamide at 25 - 30℃; for 0.25h; Stage #2: 5-(1-piperazinyl)benzofuran-2-carboxamide With tetrabutylammomium bromide; sodium hydrogencarbonate In N,N-dimethyl-formamide at 110 - 115℃; for 1.25h; Reagent/catalyst; Temperature; Time; Solvent; | 95.7% |
With sodium carbonate In water at 90 - 100℃; | 94% |
Stage #1: 5-(1-piperazinyl)benzofuran-2-carboxamide With hydrogenchloride In water at 20 - 35℃; pH=6.5 - 7; Stage #2: 3-(4-chlorobutyl)-5-cyanoindole With sodium carbonate In water; isopropyl alcohol at 75 - 85℃; for 12h; Reagent/catalyst; pH-value; | 94% |
5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-benzofurancarboxylic acid ethyl ester hydrochloride
vilazodone
Conditions | Yield |
---|---|
With ammonium hydroxide In methanol at 50℃; for 22h; Reagent/catalyst; Time; Temperature; Autoclave; | 93% |
Stage #1: 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-benzofurancarboxylic acid ethyl ester hydrochloride With potassium carbonate In dichloromethane Stage #2: With sodium methylate; formamide In tetrahydrofuran at 20 - 30℃; | 90% |
With ammonia In dimethyl sulfoxide at 20 - 35℃; | 81.6% |
With ammonium hydroxide In 1-methyl-pyrrolidin-2-one | 40.5 g |
3-(4-hydroxybutyl)-1H-indole-5-carbonitrile
5-(1-piperazinyl)benzofuran-2-carboxamide
vilazodone
Conditions | Yield |
---|---|
With trifluoroacetic acid at 60℃; for 12h; Temperature; | 91.2% |
vilazodone
Conditions | Yield |
---|---|
Stage #1: ClH*C33H38N4O5 With potassium carbonate In dichloromethane Stage #2: With sodium methylate; formamide In tetrahydrofuran at 20 - 30℃; for 8h; | 90% |
vilazodone
Conditions | Yield |
---|---|
Stage #1: ClH*C34H40N4O5 With potassium carbonate In dichloromethane Stage #2: With sodium methylate; formamide In tetrahydrofuran at 20 - 30℃; | 90% |
vilazodone
Conditions | Yield |
---|---|
Stage #1: n-butyl 5-(4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl)benzofuran-2-carboxylate hydrochloride With potassium carbonate In dichloromethane Stage #2: With sodium methylate; formamide In tetrahydrofuran at 20 - 30℃; Reagent/catalyst; Solvent; Temperature; | 85% |
5-[4-[4-[5-cyano-1-(p-toluenesulfonyl)-1H-indol-3-yl]butyl]piperazin-1-yl]benzofuran-2-carboxamide
vilazodone
Conditions | Yield |
---|---|
With sodium hydroxide In methanol at 20 - 65℃; for 2h; | 84.1% |
With sodium hydroxide In methanol at 60 - 65℃; for 2h; | 81% |
With potassium carbonate In methanol; water for 2h; Inert atmosphere; Reflux; |
3-(4-chlorobutyl)-5-cyanoindole
vilazodone
Conditions | Yield |
---|---|
With potassium hydrogencarbonate; sodium iodide In N,N-dimethyl-formamide at 95 - 105℃; for 20h; | 83% |
vilazodone
Conditions | Yield |
---|---|
With sodium tetrahydroborate; trifluoroacetic acid In dichloromethane at 10 - 45℃; for 16h; | 82.5% |
vilazodone
Conditions | Yield |
---|---|
With ammonia In dimethyl sulfoxide at 20 - 35℃; under 3750.38 - 4500.45 Torr; | 81.6% |
vilazodone
Conditions | Yield |
---|---|
Stage #1: 5-(4-(3-(5-cyano-1H-indol-3-yl)butyl)piperazin-1-yl)-benzofuran-2-carboxylic acid With 1,1'-carbonyldiimidazole In methanol at 20℃; for 1h; Reflux; Large scale; Stage #2: With ammonia In N,N-dimethyl-formamide for 0.5h; Reagent/catalyst; Large scale; | 81% |
3-(4-oxobutyl)-1H-indole-5-carbonitrile
5-(1-piperazinyl)benzofuran-2-carboxamide
vilazodone
Conditions | Yield |
---|---|
Stage #1: 5-(1-piperazinyl)benzofuran-2-carboxamide With sodium cyanoborohydride In methanol at 20℃; Stage #2: 3-(4-oxobutyl)-1H-indole-5-carbonitrile In methanol at 20℃; for 18h; | 75.21% |
5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxylic acid
vilazodone
Conditions | Yield |
---|---|
With N,N-diethyl-N-isopropylamine; 2-chloro-1-methyl-pyridinium iodide; ammonia In 1-methyl-pyrrolidin-2-one | 72% |
5-(4-[4-(5-cyano-3-indolyl)butyl]-1-piperazinyl)benzofuran-2-carboxylic acid ethyl ester
vilazodone
Conditions | Yield |
---|---|
With potassium hydroxide In methanol | 72% |
Multi-step reaction with 2 steps 1: KOH / methanol / 3 h / Heating 2: 72 percent / 1-methyl-2-chloropyridinium iodide; Et2NiPr; NH3(g) / 1-methyl-pyrrolidin-2-one View Scheme | |
With ammonium hydroxide In water; acetonitrile at 0 - 20℃; for 98h; Time; Reagent/catalyst; Temperature; |
3-(4-chlorobutyl)-5-cyanoindole
vilazodone
Conditions | Yield |
---|---|
Stage #1: n-propyl 5-(piperazin-1-yl)benzofuran-2-carboxylate; 3-(4-chlorobutyl)-5-cyanoindole With tetrabutylammomium bromide; potassium carbonate; potassium iodide In acetonitrile Reflux; Stage #2: With ammonium hydroxide In acetonitrile at 25 - 30℃; for 72h; | 72% |
3-(4-chlorobutyl)-5-cyanoindole
vilazodone
Conditions | Yield |
---|---|
Stage #1: isopropyl 5-(piperazin-1-yl)benzofuran-2-carboxylate; 3-(4-chlorobutyl)-5-cyanoindole With tetrabutylammomium bromide; potassium carbonate; potassium iodide In acetonitrile Reflux; Stage #2: With ammonium hydroxide In acetonitrile at 25 - 30℃; for 72h; | 70% |
3-(4-chlorobutyl)-5-cyanoindole
vilazodone
Conditions | Yield |
---|---|
Stage #1: n-butyl 5-(piperazin-1-yl)benzofuran-2-carboxylate; 3-(4-chlorobutyl)-5-cyanoindole With tetrabutylammomium bromide; potassium carbonate; potassium iodide In acetonitrile Reflux; Stage #2: With ammonium hydroxide In acetonitrile at 25 - 30℃; for 72h; | 70% |
3-(4-chlorobutyl)-5-cyanoindole
vilazodone
Conditions | Yield |
---|---|
Stage #1: methyl 5-(1-piperazinyl)-benzofuran-2-carboxylate; 3-(4-chlorobutyl)-5-cyanoindole With tetrabutylammomium bromide; potassium carbonate; potassium iodide In acetonitrile Reflux; Stage #2: With ammonium hydroxide In acetonitrile at 25 - 30℃; for 72h; | 65% |
1H-indole-5-carbonitrile
vilazodone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 73 percent / isobutyl-AlCl2 / CH2Cl2 / 15 - 30 °C 2: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 3: K2CO3; Et3N / acetonitrile / 12 h / Heating 4: KOH / methanol / 3 h / Heating 5: 72 percent / 1-methyl-2-chloropyridinium iodide; Et2NiPr; NH3(g) / 1-methyl-pyrrolidin-2-one View Scheme | |
Multi-step reaction with 4 steps 1: isobutylaluminum dichloride / dichloromethane 2: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran 3: potassium carbonate / acetonitrile 4: potassium hydroxide / methanol View Scheme | |
Multi-step reaction with 5 steps 1.1: isobutylaluminum dichloride / dichloromethane 2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran 3.1: potassium carbonate / acetonitrile 4.1: potassium hydroxide / methanol 5.1: 1,1'-carbonyldiimidazole / methanol / 1 h / 20 °C / Reflux; Large scale 5.2: 0.5 h / Large scale View Scheme |
ethyl 5-nitrobenzo[d]furan-2-carboxylate
vilazodone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 93 percent / H2 / Raney Ni / methanol / 27 h / 28 °C 2: 27 percent / K2CO3 / butan-1-ol / 48 h / Heating 3: K2CO3; Et3N / acetonitrile / 12 h / Heating 4: KOH / methanol / 3 h / Heating 5: 72 percent / 1-methyl-2-chloropyridinium iodide; Et2NiPr; NH3(g) / 1-methyl-pyrrolidin-2-one View Scheme | |
Multi-step reaction with 4 steps 1.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 33 - 38 °C / 3000.3 - 3750.38 Torr 2.1: tetrabutylammomium bromide; potassium carbonate / o-xylene / 32 h / 135 - 140 °C 3.1: tetrabutylammomium bromide; triethylamine / 10 h / 85 - 90 °C 3.2: 50 - 55 °C / pH 2 / Reflux 4.1: ammonia / dimethyl sulfoxide / 20 - 35 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 33 - 38 °C / 3000.3 - 3750.38 Torr 2.1: tetrabutylammomium bromide; potassium carbonate / o-xylene / 32 h / 135 - 140 °C 3.1: tetrabutylammomium bromide; triethylamine / 10 h / 85 - 90 °C 3.2: 50 - 55 °C / pH 2 / Reflux 4.1: ammonia / dimethyl sulfoxide / 20 - 35 °C View Scheme |
vilazodone
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran; water; acetone at 55℃; for 0.5h; pH=1; | 99% |
With hydrogenchloride In isopropyl alcohol at 80℃; Temperature; | 98.7% |
Stage #1: vilazodone With pyrographite In isopropyl alcohol at 25 - 30℃; for 0.0833333h; Stage #2: With isopropanolic hydrochloride In isopropyl alcohol at 20 - 45℃; for 2h; Temperature; Time; Solvent; | 92% |
vilazodone
Conditions | Yield |
---|---|
Stage #1: vilazodone In isopropyl alcohol for 0.75h; Reflux; Stage #2: With hydrogenchloride In isopropyl alcohol at 60 - 70℃; | 98% |
Stage #1: vilazodone With pyrographite In tetrahydrofuran Stage #2: With hydrogenchloride In tetrahydrofuran | 98.7% |
With hydrogenchloride In tetrahydrofuran; water at 35 - 50℃; for 1h; | 95% |
trifluoroacetic acid
vilazodone
Conditions | Yield |
---|---|
In ethyl acetate at 85℃; Solvent; Temperature; | 93.1% |
vilazodone
Conditions | Yield |
---|---|
With sulfuric acid In n-heptane at 95℃; Reagent/catalyst; Solvent; | 92.3% |
Conditions | Yield |
---|---|
With dmap; bis(1,5-cyclooctadiene)nickel(0); trimethylphosphane In toluene at 130℃; for 12h; Glovebox; Sealed tube; | 91% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View