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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 6-Aminopenicillanic Acid supplier in China

Cas:551-16-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White or almost white crystalline powder white crystalline powder Assay

High purity Various Specifications 6-Aminopenicillanic acid CAS:551-16-6

Cas:551-16-6

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

High quality 6-Aminopenicillanic Acid supplier in China

Cas:551-16-6

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Hefei TNJ chemical industry co.,ltd

Good quality Competitive price On time delivery Our Advantages: Full experience of large numbers containers loading in main Chinese seaports Packing with pallet as buyer's special request Best service after shipment with e-mail

CAS 551-16-6, 6-Aminopenicillanic acid price

Cas:551-16-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 6-aminopenicillanic acid

Cas:551-16-6

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 6-Aminopenicillanic acid 551-16-6 ISO Producer

Cas:551-16-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

6-Aminopenicillanic acid

Cas:551-16-6

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

6-Aminopenicillanic acid Manufacturer/High quality/Best price/In stock

Cas:551-16-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

6-Aminopenicillanic acid

Cas:551-16-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

6-Aminopenicillanic acid

Cas:551-16-6

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Low price CAS 551-16-6 with high quality products

Cas:551-16-6

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

6-Aminopenicillanic acid

Cas:551-16-6

Min.Order:1 Kilogram

FOB Price: $2.5 / 5.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High qu

Highest Quality 99% 6-Aminopenicillanic Acid CAS: 551-16-6

Cas:551-16-6

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White to cream fine powder Storage:Room temperature Package:25kg/drum Application:Pharmaceutical intermediates Transportation:Express/Sea/Air Port:Any port in china

High Quality 6-Aminopenicillanic acid (6-APA) Amoxicillin Impurity A

Cas:551-16-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

6-Aminopenicillanic acid 551-16-6

Cas:551-16-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

6-Aminopenicillanic acid

Cas:551-16-6

Min.Order:1 Kilogram

FOB Price: $55.0 / 60.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

6-Aminopenicillanic acid CAS:551-16-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic in

6-Aminopenicillanic acid CAS:551-16-6

Cas:551-16-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

6-Aminopenicillanic acid

Cas:551-16-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

6-aminopenicilanic acid(6-APA) CAS 551-16-6

Cas:551-16-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

6-Aminopenicillanic acid CAS NO.551-16-6 CAS NO.551-16-6

Cas:551-16-6

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

inquiry

Leader Biochemical Group

PRODUCT DETAILS

China Largest Factory Manufacturer sales 6-Aminopenicillanic acid/6-APA CAS 551-16-6

Cas:551-16-6

Min.Order:500 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

6-Aminopenicillanic acid

Cas:551-16-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/Courie

6-Aminopenicillanic acid

Cas:551-16-6

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Zhengzhou Yuanli Biological Technology Co., Ltd.

Product Name:6-Aminopenicillanic acid CAS No.:551-16-6 MF:C8H12N2O3S MW:216.26 Appearance : White to cream fine powder Packaging : 1kg/Bag, or depends on your requirements EINECS NO :208-993-4 Shipping: Timely delivery after your payment Adv

Good quality 6-Aminopenicillanic acid

Cas:551-16-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

6-Aminopenicillanic acid

Cas:551-16-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

6-Aminopenicillanic acid

Cas:551-16-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd

6-APA 6-Aminopenicillanic acid

Cas:551-16-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

6-Aminopenicillanic acid

Cas:551-16-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hefei Zhaobo Technology Co., Ltd.

Our Advantages Production: Advanced chemical equipment with years of experience.Staffs for producing various extract products. Quality Control:A complete set of Testing Professional and Analysis Equipment ensures the Quality Requirements and Speci

6-Aminopenicillanic Acid CAS 551-16-6

Cas:551-16-6

Min.Order:1 Kilogram

FOB Price: $150.0 / 180.0

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 6-Aminopenicillanic Acid

Cas:551-16-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Synthetic route

(2S,5R,6R)-Benzyl 6-Azido-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate
129096-81-7

(2S,5R,6R)-Benzyl 6-Azido-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethyl acetate for 3h; Ambient temperature;59%
penicillin G
61-33-6

penicillin G

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

Conditions
ConditionsYield
With penicillin-amidase from penicillium chrysogenum-stems
With penicillin G acylase; water at 28 - 29℃; pH=Ca. 8; Enzymatic reaction;
6R(β)-tritylaminopenicillanic acid
40124-92-3

6R(β)-tritylaminopenicillanic acid

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

Conditions
ConditionsYield
With hydrogenchloride; isopropyl alcohol
(i) aq. H3PO4, benzene, (ii) aq. HCl, iPrOH; Multistep reaction;
Penicillin G potassium
113-98-4

Penicillin G potassium

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

Conditions
ConditionsYield
Multistep reaction;
With sodium hydroxide In aq. phosphate buffer at 55℃; pH=7.8; Catalytic behavior; Kinetics; Reagent/catalyst; Temperature; pH-value; Enzymatic reaction;
6β-(3-oxo-3H-isobenzofuran-1-ylideneamino)-penicillanic acid
55151-71-8

6β-(3-oxo-3H-isobenzofuran-1-ylideneamino)-penicillanic acid

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

Conditions
ConditionsYield
With hydrazine In tetrahydrofuran
penicillin G
61-33-6

penicillin G

A

phenylacetic acid
103-82-2

phenylacetic acid

B

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

Conditions
ConditionsYield
With sodium hydroxide at 28℃; Equilibrium constant; penicillin G amidase (E.C. 3.5.1.11) immobilized on polyacrylamide, pH 8; var. substrate concentrations;
With penicillin G acylase immobilized on aminopropyl functionalized mesocellular foam silica crooslinked using glutaraldehyde In aq. phosphate buffer at 50℃; pH=7; Kinetics; pH-value; Temperature; Concentration; Reagent/catalyst; Enzymatic reaction;
penicillins to 6β-amino-penicillanic acid

penicillins to 6β-amino-penicillanic acid

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

Conditions
ConditionsYield
fermentative und enzymatische Spaltung;
chemische Spaltung;
fermentative und enzymatische Spaltung;
chemische Spaltung;
penicillin G
61-33-6

penicillin G

penicillin-amidase

penicillin-amidase

penicillium chrysogenum-stems

penicillium chrysogenum-stems

A

phenylacetic acid
103-82-2

phenylacetic acid

B

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

Conditions
ConditionsYield
Hydrolysis;
(2S,5R,6R)-1-aza-3,3'-dimethyl-6-(4-carboxybutanamido)-7-oxo-4-thiabicyclo<3.2.0>heptane-2-carboxylic acid
26939-76-4

(2S,5R,6R)-1-aza-3,3'-dimethyl-6-(4-carboxybutanamido)-7-oxo-4-thiabicyclo<3.2.0>heptane-2-carboxylic acid

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

Conditions
ConditionsYield
With sodium hydroxide; glutaryl-7-aminocephalosporanic acid acylase In water at 25℃; pH=8.0; Enzyme kinetics; Enzymatic reaction;
6-N-[3-(2,2,5,5-tetramethyl-1-oxypyrrolin-3-yl)-propen-2-oyl]penicillanic acid

6-N-[3-(2,2,5,5-tetramethyl-1-oxypyrrolin-3-yl)-propen-2-oyl]penicillanic acid

A

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

B

(E)-3-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)acrylic acid
86073-81-6

(E)-3-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)acrylic acid

Conditions
ConditionsYield
With class A TEM-1 β-lactamase; HEPES buffer In water; dimethyl sulfoxide at 24℃; pH=7; Kinetics; Further Variations:; Reagents; Enzymatic reaction;
(3S,4R)-3-<(tert-Butyldiphenylsilyl)oxy>-4-<(2-methyl-3-buten-2-yl)thio>-2-azetidinone
128971-90-4

(3S,4R)-3-<(tert-Butyldiphenylsilyl)oxy>-4-<(2-methyl-3-buten-2-yl)thio>-2-azetidinone

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 90 percent / 2,6-lutidine / tetrahydrofuran / 2 h / -78 °C
2: 1) ozone, 2) Me2S / 1) CH2Cl2, -78 deg C, 2) 0 deg C, 15 min
3: 1) t-BuOK / 1) THF, t-BuOH, 0 deg C, 15 min, 2) 0 deg C, 40 h
4: 62 percent / Et3N, AcCl / CH2Cl2 / 20 h / 0 °C
5: 1) tetrabutylammonium fluoride, 2) ozone / 1) THF, -78 deg C, 1 h, 2) CH2Cl2, -78 deg C
6: 89 percent / DBU / CH2Cl2 / 8 h / Ambient temperature
7: 40 mg / Et3N / CH2Cl2 / 0.25 h / 0 °C
8: 90 percent / LiN3 / dimethylformamide / 18 h / Ambient temperature
9: 59 percent / H2 / 10 percent Pd/C / ethyl acetate / 3 h / Ambient temperature
View Scheme
(2S,5R,6S)-Benzyl 3,3-Dimethyl-7-oxo-6-<<(trifluoromethyl)sulfonyl>oxy>-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate
128971-96-0

(2S,5R,6S)-Benzyl 3,3-Dimethyl-7-oxo-6-<<(trifluoromethyl)sulfonyl>oxy>-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / LiN3 / dimethylformamide / 18 h / Ambient temperature
2: 59 percent / H2 / 10 percent Pd/C / ethyl acetate / 3 h / Ambient temperature
View Scheme
(3S,4R)-3-<(tert-Butyldiphenylsilyl)oxy>-1-<(2,3-dimethyl-2-butyl)dimethylsilyl>-4-<(2-methyl-3-buten-2-yl)thio>-2-azetidinone
128971-91-5

(3S,4R)-3-<(tert-Butyldiphenylsilyl)oxy>-1-<(2,3-dimethyl-2-butyl)dimethylsilyl>-4-<(2-methyl-3-buten-2-yl)thio>-2-azetidinone

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 1) ozone, 2) Me2S / 1) CH2Cl2, -78 deg C, 2) 0 deg C, 15 min
2: 1) t-BuOK / 1) THF, t-BuOH, 0 deg C, 15 min, 2) 0 deg C, 40 h
3: 62 percent / Et3N, AcCl / CH2Cl2 / 20 h / 0 °C
4: 1) tetrabutylammonium fluoride, 2) ozone / 1) THF, -78 deg C, 1 h, 2) CH2Cl2, -78 deg C
5: 89 percent / DBU / CH2Cl2 / 8 h / Ambient temperature
6: 40 mg / Et3N / CH2Cl2 / 0.25 h / 0 °C
7: 90 percent / LiN3 / dimethylformamide / 18 h / Ambient temperature
8: 59 percent / H2 / 10 percent Pd/C / ethyl acetate / 3 h / Ambient temperature
View Scheme
(3S,4R)-3-<(tert-Butyldiphenylsilyl)oxy>-1-<(2,3-dimethyl-2-butyl)dimethylsilyl>-4-<(2-methyl-3-oxo-2-propyl)thio>-2-azetidinone
128971-92-6

(3S,4R)-3-<(tert-Butyldiphenylsilyl)oxy>-1-<(2,3-dimethyl-2-butyl)dimethylsilyl>-4-<(2-methyl-3-oxo-2-propyl)thio>-2-azetidinone

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 1) t-BuOK / 1) THF, t-BuOH, 0 deg C, 15 min, 2) 0 deg C, 40 h
2: 62 percent / Et3N, AcCl / CH2Cl2 / 20 h / 0 °C
3: 1) tetrabutylammonium fluoride, 2) ozone / 1) THF, -78 deg C, 1 h, 2) CH2Cl2, -78 deg C
4: 89 percent / DBU / CH2Cl2 / 8 h / Ambient temperature
5: 40 mg / Et3N / CH2Cl2 / 0.25 h / 0 °C
6: 90 percent / LiN3 / dimethylformamide / 18 h / Ambient temperature
7: 59 percent / H2 / 10 percent Pd/C / ethyl acetate / 3 h / Ambient temperature
View Scheme
(3S,4R)-3-<(tert-Butyldiphenylsilyl)oxy>-1-<(2,3-dimethyl-2-butyl)dimethylsilyl>-4-<<4-(benzyloxy)-3-hydroxy-2-methyl-4-nitro-2-butyl>thio>-2-azetidinone
128971-93-7

(3S,4R)-3-<(tert-Butyldiphenylsilyl)oxy>-1-<(2,3-dimethyl-2-butyl)dimethylsilyl>-4-<<4-(benzyloxy)-3-hydroxy-2-methyl-4-nitro-2-butyl>thio>-2-azetidinone

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 62 percent / Et3N, AcCl / CH2Cl2 / 20 h / 0 °C
2: 1) tetrabutylammonium fluoride, 2) ozone / 1) THF, -78 deg C, 1 h, 2) CH2Cl2, -78 deg C
3: 89 percent / DBU / CH2Cl2 / 8 h / Ambient temperature
4: 40 mg / Et3N / CH2Cl2 / 0.25 h / 0 °C
5: 90 percent / LiN3 / dimethylformamide / 18 h / Ambient temperature
6: 59 percent / H2 / 10 percent Pd/C / ethyl acetate / 3 h / Ambient temperature
View Scheme
(3S,4R)-3-<(tert-Butyldiphenylsilyl)oxy>-1-<(2,3-dimethyl-2-butyl)dimethylsilyl>-4-<<4-(benzyloxy)-2-methyl-4-nitro-3(Z)-buten-2-yl>thio>-2-azetidinone
128971-94-8

(3S,4R)-3-<(tert-Butyldiphenylsilyl)oxy>-1-<(2,3-dimethyl-2-butyl)dimethylsilyl>-4-<<4-(benzyloxy)-2-methyl-4-nitro-3(Z)-buten-2-yl>thio>-2-azetidinone

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1) tetrabutylammonium fluoride, 2) ozone / 1) THF, -78 deg C, 1 h, 2) CH2Cl2, -78 deg C
2: 89 percent / DBU / CH2Cl2 / 8 h / Ambient temperature
3: 40 mg / Et3N / CH2Cl2 / 0.25 h / 0 °C
4: 90 percent / LiN3 / dimethylformamide / 18 h / Ambient temperature
5: 59 percent / H2 / 10 percent Pd/C / ethyl acetate / 3 h / Ambient temperature
View Scheme
(2R,S,5R,6S)-Benzyl 6-Hydroxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate
15139-36-3, 51056-25-8, 128971-95-9

(2R,S,5R,6S)-Benzyl 6-Hydroxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 89 percent / DBU / CH2Cl2 / 8 h / Ambient temperature
2: 40 mg / Et3N / CH2Cl2 / 0.25 h / 0 °C
3: 90 percent / LiN3 / dimethylformamide / 18 h / Ambient temperature
4: 59 percent / H2 / 10 percent Pd/C / ethyl acetate / 3 h / Ambient temperature
View Scheme
(2S,5R,6S)-Benzyl 6-Hydroxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate
51056-25-8

(2S,5R,6S)-Benzyl 6-Hydroxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 40 mg / Et3N / CH2Cl2 / 0.25 h / 0 °C
2: 90 percent / LiN3 / dimethylformamide / 18 h / Ambient temperature
3: 59 percent / H2 / 10 percent Pd/C / ethyl acetate / 3 h / Ambient temperature
View Scheme
methyl 6β-(triphenylmethylamino)penicillinate
21027-18-9

methyl 6β-(triphenylmethylamino)penicillinate

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aqueous NaOH; pyridine
2: aqueous HCl; isopropyl alcohol
View Scheme
(2S,5R,6R)-6-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
20425-27-8

(2S,5R,6R)-6-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Na2S*9H2O / acetone; H2O
2: DCC
3: N2H4 / tetrahydrofuran
View Scheme
6β-(2-carboxy-benzoylamino)-penicillanic acid
47449-42-3

6β-(2-carboxy-benzoylamino)-penicillanic acid

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: DCC
2: N2H4 / tetrahydrofuran
View Scheme
penicilin V
87-08-1

penicilin V

A

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

B

2-phenoxyacetic acid
122-59-8

2-phenoxyacetic acid

Conditions
ConditionsYield
With ammonia; pen V amidase In water pH=8.2; Enzymatic reaction;
ampicillin
69-53-4

ampicillin

A

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

B

(R)-phenylglycine
875-74-1

(R)-phenylglycine

Conditions
ConditionsYield
With α-amino ester hydrolase from Xanthomonas campestris pv. campestris (ATCC 33913) at 25℃; pH=7; Kinetics; Reagent/catalyst; pH-value; Temperature; aq. phosphate buffer; Enzymatic reaction; chemospecific reaction;
amoxicillin
26787-78-0

amoxicillin

A

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

B

p-hydroxyphenylglycine
6324-01-2

p-hydroxyphenylglycine

Conditions
ConditionsYield
With penicillin G acylase; water at 20℃; Enzymatic reaction;
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

C8H12N2O3S*C7H12N2

C8H12N2O3S*C7H12N2

Conditions
ConditionsYield
In dichloromethane at 20℃; for 1.5h;100%
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

N,N,N',N'-tetramethylguanidine
80-70-6

N,N,N',N'-tetramethylguanidine

C8H12N2O3S*C5H13N3

C8H12N2O3S*C5H13N3

Conditions
ConditionsYield
In dichloromethane at 20℃; for 1.5h;99%
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

6,6-dibromopenicillanic acid
24158-88-1

6,6-dibromopenicillanic acid

Conditions
ConditionsYield
With hydrogen bromide; bromine; sodium nitrite In water at -15 - -5℃; for 0.366667h; Time;97.4%
Stage #1: 6-Aminopenicillanic Acid With sulfuric acid; hydrogen bromide; sodium nitrite In water at 0 - 5℃; for 1.5h; pH=Ca. 2.5;
Stage #2: With dihydrogen peroxide In water at 0 - 5℃; for 1h;
93%
With sulfuric acid; bromine; sodium nitrite In dichloromethane85%
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

(S)-formyloxy(phenyl)acetyl chloride
80543-51-7

(S)-formyloxy(phenyl)acetyl chloride

(2'S,3S,5R,6R)-6-formyloxy(phenyl)acetylaminopenicillanic acid
95107-10-1

(2'S,3S,5R,6R)-6-formyloxy(phenyl)acetylaminopenicillanic acid

Conditions
ConditionsYield
With triethylamine In dichloromethane for 0.5h;97%
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

ampicillin
69-53-4

ampicillin

Conditions
ConditionsYield
With (S)-Phenylglycine methyl ester In ethylene glycol at 20℃; for 48h; Enzymatic reaction;96.7%
3,5-Dibromosalicylaldehyde
90-59-5

3,5-Dibromosalicylaldehyde

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

(2S,5R,6R)-6-{[1-(3,5-Dibromo-2-hydroxy-phenyl)-meth-(Z)-ylidene]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

(2S,5R,6R)-6-{[1-(3,5-Dibromo-2-hydroxy-phenyl)-meth-(Z)-ylidene]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

Conditions
ConditionsYield
In ethanol; acetic acid at 40℃; for 72h;96%
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

6-aminopenicillanic acid methyl ester
13789-47-4

6-aminopenicillanic acid methyl ester

Conditions
ConditionsYield
In dichloromethane at 20℃;95%
In dichloromethane at 20℃; for 1h;95%
In diethyl ether; water
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

Chloromethyl pivalate
18997-19-8

Chloromethyl pivalate

(pivaloyloxy)methyl 6β-aminopenicillinate
25031-08-7

(pivaloyloxy)methyl 6β-aminopenicillinate

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane; acetonitrile at 20℃; for 1h;95%
With triethylamine In N,N-dimethyl-formamide Ambient temperature;
With triethylamine In N,N-dimethyl-formamide
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

methyl 2-phenoxyacetate
2065-23-8

methyl 2-phenoxyacetate

penicilin V
87-08-1

penicilin V

Conditions
ConditionsYield
With recombinant Streptomyces lavendulae penicillinacylase In dimethyl sulfoxide at 30℃; for 10.8h; pH=7; Catalytic behavior; Kinetics; Concentration; pH-value; Solvent; Time; Enzymatic reaction;94.5%
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

D-2-phenyl-2-formyloxyacetyl chloride
29169-64-0

D-2-phenyl-2-formyloxyacetyl chloride

(2'R,3S,5R,6R)-6-formyloxy(phenyl)acetylaminopenicillanic acid
95107-09-8

(2'R,3S,5R,6R)-6-formyloxy(phenyl)acetylaminopenicillanic acid

Conditions
ConditionsYield
With triethylamine In dichloromethane for 0.5h;94%
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

acetylacetone
123-54-6

acetylacetone

6β-(1-methyl-3-oxobut-1-enylamino)penicillanic acid
81651-32-3

6β-(1-methyl-3-oxobut-1-enylamino)penicillanic acid

Conditions
ConditionsYield
In methanol for 16h;94%
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

phenyl chloroformate
1885-14-9

phenyl chloroformate

phenoxycarbonylaminopenicillanic acid
63019-62-5

phenoxycarbonylaminopenicillanic acid

Conditions
ConditionsYield
With potassium hydroxide In tetrahydrofuran; water at 5 - 10℃; pH 7-8;92%
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

phenyl isocyanate
103-71-9

phenyl isocyanate

triethylamine
121-44-8

triethylamine

triethylammonium (2S,5R,6R)-6-[(anilinocarbonyl)amino]-penicillanate
53093-29-1

triethylammonium (2S,5R,6R)-6-[(anilinocarbonyl)amino]-penicillanate

Conditions
ConditionsYield
Stage #1: 6-Aminopenicillanic Acid; triethylamine In N,N-dimethyl-formamide at -5℃; for 0.5h;
Stage #2: phenyl isocyanate In N,N-dimethyl-formamide at 20℃; for 3.25h;
92%
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

1,8-diazabicyclo[5.4.0]undec-7-ene
6674-22-2

1,8-diazabicyclo[5.4.0]undec-7-ene

C8H12N2O3S*C9H16N2

C8H12N2O3S*C9H16N2

Conditions
ConditionsYield
In dichloromethane at 20℃; for 1.5h;92%
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

6,6-dimethyl-3-phenyl-1,5,2-dioxathiane-4-one-2,2-dioxide

6,6-dimethyl-3-phenyl-1,5,2-dioxathiane-4-one-2,2-dioxide

(2S,5R,6R)-3,3-dimethyl-6-(2-phenyl-2-sulfoacetylamino)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid disodium salt
28002-18-8, 36417-90-0, 36417-91-1, 37544-62-0, 76194-04-2

(2S,5R,6R)-3,3-dimethyl-6-(2-phenyl-2-sulfoacetylamino)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid disodium salt

Conditions
ConditionsYield
Stage #1: 6-Aminopenicillanic Acid With N,O-bis-(trimethylsilyl)-acetamide In acetone at 30 - 35℃; for 3h;
Stage #2: 6,6-dimethyl-3-phenyl-1,5,2-dioxathiane-4-one-2,2-dioxide In acetone at 40 - 45℃; for 5h;
Stage #3: With sodium 2-ethylhexanoic acid In water; acetone at 5 - 20℃; for 2h; Temperature;
91.5%
6-Aminopenicillanic Acid

6-Aminopenicillanic Acid

6-bromopenicillanic acid
24138-28-1

6-bromopenicillanic acid

tert-butyl isothiocyanate
590-42-1

tert-butyl isothiocyanate

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

triethylamine
121-44-8

triethylamine

triethylammonium (2S,5R,6R)-6-{[(tert-butylamino)-carbonothioyl]amino}penicillanate
1584804-32-9

triethylammonium (2S,5R,6R)-6-{[(tert-butylamino)-carbonothioyl]amino}penicillanate

Conditions
ConditionsYield
Stage #1: 6-Aminopenicillanic Acid; triethylamine In N,N-dimethyl-formamide at -5℃; for 0.5h;
Stage #2: tert-butyl isothiocyanate In N,N-dimethyl-formamide at 20℃; for 3.25h;
91%
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

benzophenone hydrazone
5350-57-2

benzophenone hydrazone

diphenylmethyl (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide

diphenylmethyl (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide

Conditions
ConditionsYield
With peracetic acid In dichloromethane; water; acetone at -5 - 5℃; for 1h;91%
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

carbon dioxide
124-38-9

carbon dioxide

sodium hydrogencarbonate
144-55-8

sodium hydrogencarbonate

8-hydroxypenillic acid (3,3-dimethyl-8-oxo-4-thia-1,7-diazabicyclo[3.3.0]octane-2,6-dicarboxylic acid) disodium

8-hydroxypenillic acid (3,3-dimethyl-8-oxo-4-thia-1,7-diazabicyclo[3.3.0]octane-2,6-dicarboxylic acid) disodium

Conditions
ConditionsYield
In water at 20℃; for 24h;90%
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

carbon dioxide
124-38-9

carbon dioxide

8-hydroxypenillic acid (3,3-dimethyl-8-oxo-4-thia-1,7-diazabicyclo[3.3.0]octane-2,6-dicarboxylic acid) disodium

8-hydroxypenillic acid (3,3-dimethyl-8-oxo-4-thia-1,7-diazabicyclo[3.3.0]octane-2,6-dicarboxylic acid) disodium

Conditions
ConditionsYield
With sodium hydrogencarbonate In water at 20℃; for 24h;90%
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(2S,5R,6R)-6-(tert-butoxycarbonylamino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
26531-14-6

(2S,5R,6R)-6-(tert-butoxycarbonylamino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane; water at 20℃; for 24h;90%
With triethylamine In 1,4-dioxane; water at 20℃; for 24h;
With triethylamine In dichloromethane at 20℃; for 5h;
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

racemic α-sulfophenylacetic acid
41360-32-1

racemic α-sulfophenylacetic acid

(2S,5R,6R)-3,3-dimethyl-6-(2-phenyl-2-sulfoacetylamino)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid disodium salt
28002-18-8, 36417-90-0, 36417-91-1, 37544-62-0, 76194-04-2

(2S,5R,6R)-3,3-dimethyl-6-(2-phenyl-2-sulfoacetylamino)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid disodium salt

Conditions
ConditionsYield
Stage #1: racemic α-sulfophenylacetic acid With triethanolamine; 1,1'-carbonyldiimidazole In dichloromethane; toluene at -10℃; for 1.5h;
Stage #2: 6-Aminopenicillanic Acid In dichloromethane; water; isopropyl alcohol; acetone; toluene at -5 - 10℃; for 0.75h;
Stage #3: With sodium hydroxide In water pH=6 - 7; Concentration; Solvent;
88.1%
Stage #1: racemic α-sulfophenylacetic acid With propionyl chloride; triethylamine In dichloromethane at 0 - 25℃; for 3h;
Stage #2: 6-Aminopenicillanic Acid With 2,2,2-trifluoro-N,N-bis(trimethylsilyl)-acetamide In ethyl acetate at 50℃; for 2h; Inert atmosphere;
Stage #3: With hydrogenchloride; sodium isooctanoate In ethanol; water at 0 - 25℃; for 0.75h; Reflux;
84%
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

benzyl chloroformate
501-53-1

benzyl chloroformate

<2S-<2α,5α,6β>>-3,3-dimethyl-7-oxo-6-<<(phenylmethoxy)carbonyl>amino>-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid
23536-59-6

<2S-<2α,5α,6β>>-3,3-dimethyl-7-oxo-6-<<(phenylmethoxy)carbonyl>amino>-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In diethyl ether; water for 2h;88%
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

coumarin 3-carboxylic acid chloride
3757-06-0

coumarin 3-carboxylic acid chloride

(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(2-oxo-2H-chromene-3-carbonyl)-amino]-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(2-oxo-2H-chromene-3-carbonyl)-amino]-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

Conditions
ConditionsYield
With triethylamine In acetone at 30℃; for 24h;88%
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

penicillanic acid
87-53-6

penicillanic acid

Conditions
ConditionsYield
Stage #1: 6-Aminopenicillanic Acid With sulfuric acid; sodium nitrite In water at -10 - 5℃; for 1h;
Stage #2: With sodium hypophosphite In water at -5 - 30℃; for 2h;
88%
Multi-step reaction with 2 steps
1: NaBr, NaNO2 / H2SO4; H2O / 1 h / 0 °C
2: hydrogen / 5 percent palladium-on-CaCO3 / various solvent(s) / 24 h / 20 °C / 2068.6 Torr
View Scheme
Stage #1: 6-Aminopenicillanic Acid With hydrogenchloride; sodium nitrite In water at -5℃; for 5h;
Stage #2: With hypophosphorous acid; copper In ethanol; dichloromethane; water at 5℃; for 3h; Solvent; Reagent/catalyst; Heating;
N,N-Bis(trimethylsilyl)urea
57397-48-5

N,N-Bis(trimethylsilyl)urea

6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

Conditions
ConditionsYield
With chloro-trimethyl-silane; triethylamine In dichloromethane87.6%
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

diazodiphenylmethane
908093-98-1

diazodiphenylmethane

6-aminopenicillanic acid diphenylmethyl ester
47547-28-4, 78184-79-9

6-aminopenicillanic acid diphenylmethyl ester

Conditions
ConditionsYield
In methanol; dichloromethane at 20℃;87%
In methanol; dichloromethane at 20℃; for 15h;40%
With methanol In dichloromethane
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

3,5-dichlorosalicyclaldehyde
90-60-8

3,5-dichlorosalicyclaldehyde

(2S,5R,6R)-6-{[1-(3,5-Dichloro-2-hydroxy-phenyl)-meth-(Z)-ylidene]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

(2S,5R,6R)-6-{[1-(3,5-Dichloro-2-hydroxy-phenyl)-meth-(Z)-ylidene]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

Conditions
ConditionsYield
In ethanol; acetic acid at 40℃; for 72h;86%
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

A

(R)-phenylglycine
875-74-1

(R)-phenylglycine

B

ampicillin
69-53-4

ampicillin

Conditions
ConditionsYield
With A. faecalis; immobilised penicillin acylase (EC 3.5.1.11) In water; acetonitrile at 0℃; Product distribution; Kinetics; Further Variations:; Solvents; reusing run; Enzymatic reaction;A n/a
B 86%
6-Aminopenicillanic Acid
551-16-6

6-Aminopenicillanic Acid

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

diazodiphenylmethane
908093-98-1

diazodiphenylmethane

Diphenylmethyl 6-aminopenicillanate p-toluenesulphonic acid salt
34642-75-6

Diphenylmethyl 6-aminopenicillanate p-toluenesulphonic acid salt

Conditions
ConditionsYield
In water; acetone for 1h;85%
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