Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:551-16-6
Min.Order:1 Kilogram
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inquiryItems Standard Result Appearance White or almost white crystalline powder white crystalline powder Assay
Cas:551-16-6
Min.Order:1 Gram
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Type:Manufacturers
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:551-16-6
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inquiryGood quality Competitive price On time delivery Our Advantages: Full experience of large numbers containers loading in main Chinese seaports Packing with pallet as buyer's special request Best service after shipment with e-mail
Cas:551-16-6
Min.Order:1 Kilogram
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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Cas:551-16-6
Min.Order:1 Gram
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inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:551-16-6
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:551-16-6
Min.Order:5 Kiloliter
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Type:Manufacturers
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:551-16-6
Min.Order:1 Kilogram
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Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:551-16-6
Min.Order:10 Gram
FOB Price: $146.0 / 176.0
Type:Trading Company
inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
Cas:551-16-6
Min.Order:1 Kilogram
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Type:Trading Company
inquiryOur Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High qu
Cas:551-16-6
Min.Order:100 Gram
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Type:Other
inquiryAppearance:White to cream fine powder Storage:Room temperature Package:25kg/drum Application:Pharmaceutical intermediates Transportation:Express/Sea/Air Port:Any port in china
Cas:551-16-6
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:551-16-6
Min.Order:1 Kilogram
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:551-16-6
Min.Order:1 Kilogram
FOB Price: $55.0 / 60.0
Type:Trading Company
inquiry6-Aminopenicillanic acid CAS:551-16-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic in
Cas:551-16-6
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:551-16-6
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:551-16-6
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryProduct Detail Minimum Order Qty. 10 Gram
Cas:551-16-6
Min.Order:20 Metric Ton
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Type:Trading Company
inquiryPRODUCT DETAILS
Cas:551-16-6
Min.Order:500 Kilogram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Appearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/Courie
Cas:551-16-6
Min.Order:100 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryProduct Name:6-Aminopenicillanic acid CAS No.:551-16-6 MF:C8H12N2O3S MW:216.26 Appearance : White to cream fine powder Packaging : 1kg/Bag, or depends on your requirements EINECS NO :208-993-4 Shipping: Timely delivery after your payment Adv
Cas:551-16-6
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:551-16-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:551-16-6
Min.Order:0 Metric Ton
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Type:Lab/Research institutions
inquiryPacking: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Our Advantages Production: Advanced chemical equipment with years of experience.Staffs for producing various extract products. Quality Control:A complete set of Testing Professional and Analysis Equipment ensures the Quality Requirements and Speci
Cas:551-16-6
Min.Order:1 Kilogram
FOB Price: $150.0 / 180.0
Type:Trading Company
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:551-16-6
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiry(2S,5R,6R)-Benzyl 6-Azido-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate
6-Aminopenicillanic Acid
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In ethyl acetate for 3h; Ambient temperature; | 59% |
Conditions | Yield |
---|---|
With penicillin-amidase from penicillium chrysogenum-stems | |
With penicillin G acylase; water at 28 - 29℃; pH=Ca. 8; Enzymatic reaction; |
6R(β)-tritylaminopenicillanic acid
6-Aminopenicillanic Acid
Conditions | Yield |
---|---|
With hydrogenchloride; isopropyl alcohol | |
(i) aq. H3PO4, benzene, (ii) aq. HCl, iPrOH; Multistep reaction; |
Conditions | Yield |
---|---|
Multistep reaction; | |
With sodium hydroxide In aq. phosphate buffer at 55℃; pH=7.8; Catalytic behavior; Kinetics; Reagent/catalyst; Temperature; pH-value; Enzymatic reaction; |
6β-(3-oxo-3H-isobenzofuran-1-ylideneamino)-penicillanic acid
6-Aminopenicillanic Acid
Conditions | Yield |
---|---|
With hydrazine In tetrahydrofuran |
Conditions | Yield |
---|---|
With sodium hydroxide at 28℃; Equilibrium constant; penicillin G amidase (E.C. 3.5.1.11) immobilized on polyacrylamide, pH 8; var. substrate concentrations; | |
With penicillin G acylase immobilized on aminopropyl functionalized mesocellular foam silica crooslinked using glutaraldehyde In aq. phosphate buffer at 50℃; pH=7; Kinetics; pH-value; Temperature; Concentration; Reagent/catalyst; Enzymatic reaction; |
6-Aminopenicillanic Acid
Conditions | Yield |
---|---|
fermentative und enzymatische Spaltung; | |
chemische Spaltung; | |
fermentative und enzymatische Spaltung; | |
chemische Spaltung; |
Conditions | Yield |
---|---|
Hydrolysis; |
(2S,5R,6R)-1-aza-3,3'-dimethyl-6-(4-carboxybutanamido)-7-oxo-4-thiabicyclo<3.2.0>heptane-2-carboxylic acid
6-Aminopenicillanic Acid
Conditions | Yield |
---|---|
With sodium hydroxide; glutaryl-7-aminocephalosporanic acid acylase In water at 25℃; pH=8.0; Enzyme kinetics; Enzymatic reaction; |
A
6-Aminopenicillanic Acid
B
(E)-3-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)acrylic acid
Conditions | Yield |
---|---|
With class A TEM-1 β-lactamase; HEPES buffer In water; dimethyl sulfoxide at 24℃; pH=7; Kinetics; Further Variations:; Reagents; Enzymatic reaction; |
(3S,4R)-3-<(tert-Butyldiphenylsilyl)oxy>-4-<(2-methyl-3-buten-2-yl)thio>-2-azetidinone
6-Aminopenicillanic Acid
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: 90 percent / 2,6-lutidine / tetrahydrofuran / 2 h / -78 °C 2: 1) ozone, 2) Me2S / 1) CH2Cl2, -78 deg C, 2) 0 deg C, 15 min 3: 1) t-BuOK / 1) THF, t-BuOH, 0 deg C, 15 min, 2) 0 deg C, 40 h 4: 62 percent / Et3N, AcCl / CH2Cl2 / 20 h / 0 °C 5: 1) tetrabutylammonium fluoride, 2) ozone / 1) THF, -78 deg C, 1 h, 2) CH2Cl2, -78 deg C 6: 89 percent / DBU / CH2Cl2 / 8 h / Ambient temperature 7: 40 mg / Et3N / CH2Cl2 / 0.25 h / 0 °C 8: 90 percent / LiN3 / dimethylformamide / 18 h / Ambient temperature 9: 59 percent / H2 / 10 percent Pd/C / ethyl acetate / 3 h / Ambient temperature View Scheme |
(2S,5R,6S)-Benzyl 3,3-Dimethyl-7-oxo-6-<<(trifluoromethyl)sulfonyl>oxy>-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate
6-Aminopenicillanic Acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / LiN3 / dimethylformamide / 18 h / Ambient temperature 2: 59 percent / H2 / 10 percent Pd/C / ethyl acetate / 3 h / Ambient temperature View Scheme |
(3S,4R)-3-<(tert-Butyldiphenylsilyl)oxy>-1-<(2,3-dimethyl-2-butyl)dimethylsilyl>-4-<(2-methyl-3-buten-2-yl)thio>-2-azetidinone
6-Aminopenicillanic Acid
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 1) ozone, 2) Me2S / 1) CH2Cl2, -78 deg C, 2) 0 deg C, 15 min 2: 1) t-BuOK / 1) THF, t-BuOH, 0 deg C, 15 min, 2) 0 deg C, 40 h 3: 62 percent / Et3N, AcCl / CH2Cl2 / 20 h / 0 °C 4: 1) tetrabutylammonium fluoride, 2) ozone / 1) THF, -78 deg C, 1 h, 2) CH2Cl2, -78 deg C 5: 89 percent / DBU / CH2Cl2 / 8 h / Ambient temperature 6: 40 mg / Et3N / CH2Cl2 / 0.25 h / 0 °C 7: 90 percent / LiN3 / dimethylformamide / 18 h / Ambient temperature 8: 59 percent / H2 / 10 percent Pd/C / ethyl acetate / 3 h / Ambient temperature View Scheme |
(3S,4R)-3-<(tert-Butyldiphenylsilyl)oxy>-1-<(2,3-dimethyl-2-butyl)dimethylsilyl>-4-<(2-methyl-3-oxo-2-propyl)thio>-2-azetidinone
6-Aminopenicillanic Acid
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 1) t-BuOK / 1) THF, t-BuOH, 0 deg C, 15 min, 2) 0 deg C, 40 h 2: 62 percent / Et3N, AcCl / CH2Cl2 / 20 h / 0 °C 3: 1) tetrabutylammonium fluoride, 2) ozone / 1) THF, -78 deg C, 1 h, 2) CH2Cl2, -78 deg C 4: 89 percent / DBU / CH2Cl2 / 8 h / Ambient temperature 5: 40 mg / Et3N / CH2Cl2 / 0.25 h / 0 °C 6: 90 percent / LiN3 / dimethylformamide / 18 h / Ambient temperature 7: 59 percent / H2 / 10 percent Pd/C / ethyl acetate / 3 h / Ambient temperature View Scheme |
(3S,4R)-3-<(tert-Butyldiphenylsilyl)oxy>-1-<(2,3-dimethyl-2-butyl)dimethylsilyl>-4-<<4-(benzyloxy)-3-hydroxy-2-methyl-4-nitro-2-butyl>thio>-2-azetidinone
6-Aminopenicillanic Acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 62 percent / Et3N, AcCl / CH2Cl2 / 20 h / 0 °C 2: 1) tetrabutylammonium fluoride, 2) ozone / 1) THF, -78 deg C, 1 h, 2) CH2Cl2, -78 deg C 3: 89 percent / DBU / CH2Cl2 / 8 h / Ambient temperature 4: 40 mg / Et3N / CH2Cl2 / 0.25 h / 0 °C 5: 90 percent / LiN3 / dimethylformamide / 18 h / Ambient temperature 6: 59 percent / H2 / 10 percent Pd/C / ethyl acetate / 3 h / Ambient temperature View Scheme |
(3S,4R)-3-<(tert-Butyldiphenylsilyl)oxy>-1-<(2,3-dimethyl-2-butyl)dimethylsilyl>-4-<<4-(benzyloxy)-2-methyl-4-nitro-3(Z)-buten-2-yl>thio>-2-azetidinone
6-Aminopenicillanic Acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 1) tetrabutylammonium fluoride, 2) ozone / 1) THF, -78 deg C, 1 h, 2) CH2Cl2, -78 deg C 2: 89 percent / DBU / CH2Cl2 / 8 h / Ambient temperature 3: 40 mg / Et3N / CH2Cl2 / 0.25 h / 0 °C 4: 90 percent / LiN3 / dimethylformamide / 18 h / Ambient temperature 5: 59 percent / H2 / 10 percent Pd/C / ethyl acetate / 3 h / Ambient temperature View Scheme |
(2R,S,5R,6S)-Benzyl 6-Hydroxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate
6-Aminopenicillanic Acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 89 percent / DBU / CH2Cl2 / 8 h / Ambient temperature 2: 40 mg / Et3N / CH2Cl2 / 0.25 h / 0 °C 3: 90 percent / LiN3 / dimethylformamide / 18 h / Ambient temperature 4: 59 percent / H2 / 10 percent Pd/C / ethyl acetate / 3 h / Ambient temperature View Scheme |
(2S,5R,6S)-Benzyl 6-Hydroxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate
6-Aminopenicillanic Acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 40 mg / Et3N / CH2Cl2 / 0.25 h / 0 °C 2: 90 percent / LiN3 / dimethylformamide / 18 h / Ambient temperature 3: 59 percent / H2 / 10 percent Pd/C / ethyl acetate / 3 h / Ambient temperature View Scheme |
methyl 6β-(triphenylmethylamino)penicillinate
6-Aminopenicillanic Acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: aqueous NaOH; pyridine 2: aqueous HCl; isopropyl alcohol View Scheme |
(2S,5R,6R)-6-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
6-Aminopenicillanic Acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Na2S*9H2O / acetone; H2O 2: DCC 3: N2H4 / tetrahydrofuran View Scheme |
6β-(2-carboxy-benzoylamino)-penicillanic acid
6-Aminopenicillanic Acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: DCC 2: N2H4 / tetrahydrofuran View Scheme |
Conditions | Yield |
---|---|
With ammonia; pen V amidase In water pH=8.2; Enzymatic reaction; |
Conditions | Yield |
---|---|
With α-amino ester hydrolase from Xanthomonas campestris pv. campestris (ATCC 33913) at 25℃; pH=7; Kinetics; Reagent/catalyst; pH-value; Temperature; aq. phosphate buffer; Enzymatic reaction; chemospecific reaction; |
Conditions | Yield |
---|---|
With penicillin G acylase; water at 20℃; Enzymatic reaction; |
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 1.5h; | 100% |
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 1.5h; | 99% |
6-Aminopenicillanic Acid
6,6-dibromopenicillanic acid
Conditions | Yield |
---|---|
With hydrogen bromide; bromine; sodium nitrite In water at -15 - -5℃; for 0.366667h; Time; | 97.4% |
Stage #1: 6-Aminopenicillanic Acid With sulfuric acid; hydrogen bromide; sodium nitrite In water at 0 - 5℃; for 1.5h; pH=Ca. 2.5; Stage #2: With dihydrogen peroxide In water at 0 - 5℃; for 1h; | 93% |
With sulfuric acid; bromine; sodium nitrite In dichloromethane | 85% |
6-Aminopenicillanic Acid
(S)-formyloxy(phenyl)acetyl chloride
(2'S,3S,5R,6R)-6-formyloxy(phenyl)acetylaminopenicillanic acid
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 0.5h; | 97% |
Conditions | Yield |
---|---|
With (S)-Phenylglycine methyl ester In ethylene glycol at 20℃; for 48h; Enzymatic reaction; | 96.7% |
Conditions | Yield |
---|---|
In ethanol; acetic acid at 40℃; for 72h; | 96% |
diazomethane
6-Aminopenicillanic Acid
6-aminopenicillanic acid methyl ester
Conditions | Yield |
---|---|
In dichloromethane at 20℃; | 95% |
In dichloromethane at 20℃; for 1h; | 95% |
In diethyl ether; water |
6-Aminopenicillanic Acid
Chloromethyl pivalate
(pivaloyloxy)methyl 6β-aminopenicillinate
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane; acetonitrile at 20℃; for 1h; | 95% |
With triethylamine In N,N-dimethyl-formamide Ambient temperature; | |
With triethylamine In N,N-dimethyl-formamide |
Conditions | Yield |
---|---|
With recombinant Streptomyces lavendulae penicillinacylase In dimethyl sulfoxide at 30℃; for 10.8h; pH=7; Catalytic behavior; Kinetics; Concentration; pH-value; Solvent; Time; Enzymatic reaction; | 94.5% |
6-Aminopenicillanic Acid
D-2-phenyl-2-formyloxyacetyl chloride
(2'R,3S,5R,6R)-6-formyloxy(phenyl)acetylaminopenicillanic acid
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 0.5h; | 94% |
6-Aminopenicillanic Acid
acetylacetone
6β-(1-methyl-3-oxobut-1-enylamino)penicillanic acid
Conditions | Yield |
---|---|
In methanol for 16h; | 94% |
6-Aminopenicillanic Acid
phenyl chloroformate
phenoxycarbonylaminopenicillanic acid
Conditions | Yield |
---|---|
With potassium hydroxide In tetrahydrofuran; water at 5 - 10℃; pH 7-8; | 92% |
6-Aminopenicillanic Acid
phenyl isocyanate
triethylamine
triethylammonium (2S,5R,6R)-6-[(anilinocarbonyl)amino]-penicillanate
Conditions | Yield |
---|---|
Stage #1: 6-Aminopenicillanic Acid; triethylamine In N,N-dimethyl-formamide at -5℃; for 0.5h; Stage #2: phenyl isocyanate In N,N-dimethyl-formamide at 20℃; for 3.25h; | 92% |
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 1.5h; | 92% |
6-Aminopenicillanic Acid
(2S,5R,6R)-3,3-dimethyl-6-(2-phenyl-2-sulfoacetylamino)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid disodium salt
Conditions | Yield |
---|---|
Stage #1: 6-Aminopenicillanic Acid With N,O-bis-(trimethylsilyl)-acetamide In acetone at 30 - 35℃; for 3h; Stage #2: 6,6-dimethyl-3-phenyl-1,5,2-dioxathiane-4-one-2,2-dioxide In acetone at 40 - 45℃; for 5h; Stage #3: With sodium 2-ethylhexanoic acid In water; acetone at 5 - 20℃; for 2h; Temperature; | 91.5% |
6-bromopenicillanic acid
tert-butyl isothiocyanate
6-Aminopenicillanic Acid
triethylamine
triethylammonium (2S,5R,6R)-6-{[(tert-butylamino)-carbonothioyl]amino}penicillanate
Conditions | Yield |
---|---|
Stage #1: 6-Aminopenicillanic Acid; triethylamine In N,N-dimethyl-formamide at -5℃; for 0.5h; Stage #2: tert-butyl isothiocyanate In N,N-dimethyl-formamide at 20℃; for 3.25h; | 91% |
Conditions | Yield |
---|---|
With peracetic acid In dichloromethane; water; acetone at -5 - 5℃; for 1h; | 91% |
Conditions | Yield |
---|---|
In water at 20℃; for 24h; | 90% |
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water at 20℃; for 24h; | 90% |
6-Aminopenicillanic Acid
di-tert-butyl dicarbonate
(2S,5R,6R)-6-(tert-butoxycarbonylamino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane; water at 20℃; for 24h; | 90% |
With triethylamine In 1,4-dioxane; water at 20℃; for 24h; | |
With triethylamine In dichloromethane at 20℃; for 5h; |
6-Aminopenicillanic Acid
racemic α-sulfophenylacetic acid
(2S,5R,6R)-3,3-dimethyl-6-(2-phenyl-2-sulfoacetylamino)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid disodium salt
Conditions | Yield |
---|---|
Stage #1: racemic α-sulfophenylacetic acid With triethanolamine; 1,1'-carbonyldiimidazole In dichloromethane; toluene at -10℃; for 1.5h; Stage #2: 6-Aminopenicillanic Acid In dichloromethane; water; isopropyl alcohol; acetone; toluene at -5 - 10℃; for 0.75h; Stage #3: With sodium hydroxide In water pH=6 - 7; Concentration; Solvent; | 88.1% |
Stage #1: racemic α-sulfophenylacetic acid With propionyl chloride; triethylamine In dichloromethane at 0 - 25℃; for 3h; Stage #2: 6-Aminopenicillanic Acid With 2,2,2-trifluoro-N,N-bis(trimethylsilyl)-acetamide In ethyl acetate at 50℃; for 2h; Inert atmosphere; Stage #3: With hydrogenchloride; sodium isooctanoate In ethanol; water at 0 - 25℃; for 0.75h; Reflux; | 84% |
6-Aminopenicillanic Acid
benzyl chloroformate
<2S-<2α,5α,6β>>-3,3-dimethyl-7-oxo-6-<<(phenylmethoxy)carbonyl>amino>-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In diethyl ether; water for 2h; | 88% |
Conditions | Yield |
---|---|
With triethylamine In acetone at 30℃; for 24h; | 88% |
Conditions | Yield |
---|---|
Stage #1: 6-Aminopenicillanic Acid With sulfuric acid; sodium nitrite In water at -10 - 5℃; for 1h; Stage #2: With sodium hypophosphite In water at -5 - 30℃; for 2h; | 88% |
Multi-step reaction with 2 steps 1: NaBr, NaNO2 / H2SO4; H2O / 1 h / 0 °C 2: hydrogen / 5 percent palladium-on-CaCO3 / various solvent(s) / 24 h / 20 °C / 2068.6 Torr View Scheme | |
Stage #1: 6-Aminopenicillanic Acid With hydrogenchloride; sodium nitrite In water at -5℃; for 5h; Stage #2: With hypophosphorous acid; copper In ethanol; dichloromethane; water at 5℃; for 3h; Solvent; Reagent/catalyst; Heating; |
N,N-Bis(trimethylsilyl)urea
6-Aminopenicillanic Acid
ampicillin trihydrate
Conditions | Yield |
---|---|
With chloro-trimethyl-silane; triethylamine In dichloromethane | 87.6% |
6-Aminopenicillanic Acid
diazodiphenylmethane
6-aminopenicillanic acid diphenylmethyl ester
Conditions | Yield |
---|---|
In methanol; dichloromethane at 20℃; | 87% |
In methanol; dichloromethane at 20℃; for 15h; | 40% |
With methanol In dichloromethane |
Conditions | Yield |
---|---|
In ethanol; acetic acid at 40℃; for 72h; | 86% |
6-Aminopenicillanic Acid
(R)-phenylglycine amide
A
(R)-phenylglycine
B
ampicillin
Conditions | Yield |
---|---|
With A. faecalis; immobilised penicillin acylase (EC 3.5.1.11) In water; acetonitrile at 0℃; Product distribution; Kinetics; Further Variations:; Solvents; reusing run; Enzymatic reaction; | A n/a B 86% |
6-Aminopenicillanic Acid
toluene-4-sulfonic acid
diazodiphenylmethane
Diphenylmethyl 6-aminopenicillanate p-toluenesulphonic acid salt
Conditions | Yield |
---|---|
In water; acetone for 1h; | 85% |
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