Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:168273-06-1
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquirySpecifications CAS No.: 168273-06-1 Other Names: loss weight Rimonabant MF: C22H21Cl3N4O EINECS No.: 168273-06-1 Place of Origin: Sh
Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi
Cas:168273-06-1
Min.Order:1 Kilogram
FOB Price: $399.0 / 444.0
Type:Manufacturers
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:168273-06-1
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res
With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:168273-06-1
Min.Order:1 Kilogram
FOB Price: $3.0 / 10.0
Type:Trading Company
inquiryTIANFUCHEM--168273-06-1--High purity Rimonabant factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business
Cas:168273-06-1
Min.Order:1 Metric Ton
FOB Price: $2000.0
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod
Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua
Cas:168273-06-1
Min.Order:10 Gram
Negotiable
Type:Other
inquiryName: Rimonabant Cas: 168273-06-1 Appearance: white powder Capacity:1MT/year Application: pharmaceutical raw material Assay: min99% Standard: enterprise Brand: WEDOCHEM Synonyms 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-pi
Cas:168273-06-1
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:168273-06-1
Min.Order:10 Gram
FOB Price: $5.0
Type:Trading Company
inquiry1.Strong backup of factory:hign ability,favorable quality and competitive price. 2.Most of our products in catalogue are have stock. 3.Free sample could be provided. 4.Suitable package to protect the product the product quality. 5.the lead time
Cas:168273-06-1
Min.Order:5 Gram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryRimonabant CAS: 168273-06-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate
Cas:168273-06-1
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe generally use secure shipping methods that do not require you to do any customs clearance. Free shipping to your address without worrying about any customs issues. We have a professional customs clearance team to 100% guarantee the safe delivery o
Cas:168273-06-1
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
Cas:168273-06-1
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Our Advantage 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good qual
Cas:168273-06-1
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Rimonabant CAS 168273-06-1 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 P
Cas:168273-06-1
Min.Order:1 Kilogram
FOB Price: $10.0 / 50.0
Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Rimonabant CAS 168273-06-1 Description Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict qualit
Cas:168273-06-1
Min.Order:1 Kilogram
FOB Price: $10.0 / 50.0
Type:Trading Company
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:168273-06-1
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:168273-06-1
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
Cas:168273-06-1
Min.Order:1 Kilogram
FOB Price: $50.0 / 100.0
Type:Trading Company
inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
High quality, competitive price, fast delivery and first-class service we possesses have won the trust and praise of customers. Standard: BP/USP/EP The purity is equal or greater than 99%. As a supplier, we can provide high-quality products. Cle
Cas:168273-06-1
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryrimonabant hydrochloride
rimonabant
Conditions | Yield |
---|---|
With methanol; potassium hydroxide; water at 0 - 5℃; for 1h; | 93% |
With sodium hydroxide In methanol; water pH=8.5; | |
With sodium hydroxide In methanol; water at 28 - 30℃; for 0.666667h; pH=11; |
1-Aminopiperidine
ethyl 1-(2,4-dichlorophenyl)-4-methyl-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylate
rimonabant
Conditions | Yield |
---|---|
With trimethylaluminum In tetrahydrofuran; toluene at 125℃; for 0.0333333h; | 88% |
magnesium chloride In acetonitrile for 2h; Product distribution / selectivity; Heating / reflux; | 83% |
magnesium bromide In tetrahydrofuran for 2h; Product distribution / selectivity; Heating / reflux; | 81% |
5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid methyl ester
1-Aminopiperidine
rimonabant
Conditions | Yield |
---|---|
magnesium chloride In tetrahydrofuran for 2h; Product distribution / selectivity; Heating / reflux; | 82% |
magnesium chloride In acetonitrile for 2h; Product distribution / selectivity; Heating / reflux; | 80% |
magnesium bromide In tetrahydrofuran for 2h; Product distribution / selectivity; Heating / reflux; | 79% |
1-Aminopiperidine
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carbonyl chloride
rimonabant
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 12h; | 79% |
With triethylamine In dichloromethane at 20℃; for 1.5h; Substitution; | 66% |
With triethylamine Yield given; |
phenyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylate
1-Aminopiperidine
rimonabant
Conditions | Yield |
---|---|
magnesium chloride In acetonitrile for 2h; Product distribution / selectivity; Heating / reflux; | 77% |
magnesium chloride In acetonitrile at 80℃; for 2 - 4h; Product distribution / selectivity; |
N-aminopiperidine hydrochloride
ethyl 1-(2,4-dichlorophenyl)-4-methyl-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylate
rimonabant
Conditions | Yield |
---|---|
With triethylamine; magnesium chloride In acetonitrile for 4h; Product distribution / selectivity; Heating / reflux; | 77% |
Stage #1: N-aminopiperidine hydrochloride With potassium tert-butylate In acetonitrile at 20℃; for 0.5h; Stage #2: ethyl 1-(2,4-dichlorophenyl)-4-methyl-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylate; magnesium chloride In acetonitrile for 4h; Product distribution / selectivity; Heating / reflux; | 61% |
N-aminopiperidine hydrogen sulphate
ethyl 1-(2,4-dichlorophenyl)-4-methyl-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylate
rimonabant
Conditions | Yield |
---|---|
With triethylamine; magnesium chloride In acetonitrile for 4h; Product distribution / selectivity; Heating / reflux; | 77% |
Conditions | Yield |
---|---|
Stage #1: rimonabant acid With benzotriazol-1-ol In dichloromethane for 0.166667h; Stage #2: With dicyclohexyl-carbodiimide In dichloromethane at 25℃; Stage #3: 1-Aminopiperidine Further stages; | 72% |
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 72h; | 68% |
Stage #1: rimonabant acid With thionyl chloride In methyl cyclohexane at 83℃; for 3h; Heating / reflux; Stage #2: With triethylamine In tetrahydrofuran; methyl cyclohexane at 12 - 20℃; for 0.25h; Stage #3: 1-Aminopiperidine With triethylamine In tetrahydrofuran; methyl cyclohexane at 12 - 20℃; Product distribution / selectivity; | |
With 1,1'-carbonyldiimidazole In tetrahydrofuran at 65 - 70℃; for 2.33333h; Product distribution / selectivity; | |
With boric acid In toluene at 29 - 112℃; for 12.83h; Product distribution / selectivity; |
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid(2,6-benzotriazolyl-piperidin-1-yl)amide
rimonabant
Conditions | Yield |
---|---|
With sodium tetrahydroborate In tetrahydrofuran at 20℃; | 46% |
1-Aminopiperidine
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carbonyl chloride
A
rimonabant
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 2h; | A 11.5 g B 645 mg |
4-(4-chlorophenyl)-3-methyl-2,4-dioxo-N-piperidin-1-yl-butyramide
2,4-dichlorophenyl hydrazine hydrochloride
rimonabant
Conditions | Yield |
---|---|
In ethanol for 8h; Product distribution / selectivity; |
5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid benzotriazol-1-yl ester
1-Aminopiperidine
rimonabant
Conditions | Yield |
---|---|
With potassium carbonate In dichloromethane at 30℃; for 0.5h; Product distribution / selectivity; |
N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-3-pyrazole carboxamide fumarate
rimonabant
Conditions | Yield |
---|---|
With sodium hydroxide; water; polyoxyethylene sorbitan monostearate at 30 - 40℃; for 4h; pH=9; Polyoxyethylene; Product distribution / selectivity; | |
With sodium hydroxide; polyoxyethylene sorbitan monooleate In water at 25 - 40℃; for 4h; pH=9; Product distribution / selectivity; |
N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-3-pyrazole carboxamide hydrogensulphate
rimonabant
Conditions | Yield |
---|---|
With ammonia; water at 25 - 30℃; for 4h; pH=9; Product distribution / selectivity; | |
With ammonia; water at 25 - 30℃; for 4h; pH=9; Product distribution / selectivity; |
4'-chloropropiophenone
rimonabant
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 65 percent / LDA; potassium t-butoxide / diethyl ether; tetrahydrofuran; heptane / 2.5 h / 20 °C 2.1: HCl / H2O; CH2Cl2 3.1: ethanol / 2.5 h / Heating 3.2: 89 percent / NaOH / ethanol / 2 h / Heating 4.1: 94 percent / SOCl2 / toluene / 6 h / Heating 5.1: 11.5 g / triethylamine / CH2Cl2 / 2 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: lithium hexamethyldisilazane / methyl cyclohexane / 3 h / 20 °C 1.2: 16 h 1.3: Cooling with ice; Reflux 2.1: potassium hydroxide / ethanol / 12 h / 50 °C 3.1: thionyl chloride / toluene / 2.5 h / 110 °C 4.1: N-ethyl-N,N-diisopropylamine / chloroform / 4 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: lithium hexamethyldisilazane / methyl cyclohexane / 2.5 h / 15 - 25 °C / Inert atmosphere 1.2: Inert atmosphere 2.1: sulfuric acid / ethanol; water / 14 h / 79 °C / Inert atmosphere 3.1: N,N-dimethyl-formamide / toluene / 0 °C / Inert atmosphere 3.2: 4 h / 100 °C / Inert atmosphere 4.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere View Scheme |
4-(4-chlorophenyl)-3-methyl-2,4-dioxobutyric acid ethyl ester
rimonabant
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: ethanol / 2.5 h / Heating 1.2: 89 percent / NaOH / ethanol / 2 h / Heating 2.1: 94 percent / SOCl2 / toluene / 6 h / Heating 3.1: 11.5 g / triethylamine / CH2Cl2 / 2 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 2.1: propionic acid / 16 h / Heating / reflux 2.2: 20 h / 140 - 145 °C View Scheme | |
Multi-step reaction with 2 steps 1: triethylamine / 3 h 2: ethanol / 8 h View Scheme |
rimonabant acid
rimonabant
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 94 percent / SOCl2 / toluene / 6 h / Heating 2: 11.5 g / triethylamine / CH2Cl2 / 2 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: DMF / CH2Cl2 / 3 h / 20 °C 2: 66 percent / triethylamine / CH2Cl2 / 1.5 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: thionyl chloride / toluene / 2.5 h / 110 °C 2: N-ethyl-N,N-diisopropylamine / chloroform / 4 h / 0 - 20 °C View Scheme |
rimonabant
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: HCl / H2O; CH2Cl2 2.1: ethanol / 2.5 h / Heating 2.2: 89 percent / NaOH / ethanol / 2 h / Heating 3.1: 94 percent / SOCl2 / toluene / 6 h / Heating 4.1: 11.5 g / triethylamine / CH2Cl2 / 2 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 95 percent / bromine / acetic acid / 1.5 h / 5 - 20 °C 2: 42 percent / NaH / tetrahydrofuran / 1.5 h / Heating 3: sodium / ethanol / 2.5 h / 0 °C 4: 45 percent / NaOH / ethanol / 1.5 h / Alkaline hydrolysis 5: DMF / CH2Cl2 / 3 h / 20 °C 6: 66 percent / triethylamine / CH2Cl2 / 1.5 h / 20 °C View Scheme |
2-bromo-1-(4-chlorophenyl)-1-propanone
rimonabant
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 42 percent / NaH / tetrahydrofuran / 1.5 h / Heating 2: sodium / ethanol / 2.5 h / 0 °C 3: 45 percent / NaOH / ethanol / 1.5 h / Alkaline hydrolysis 4: DMF / CH2Cl2 / 3 h / 20 °C 5: 66 percent / triethylamine / CH2Cl2 / 1.5 h / 20 °C View Scheme |
2,4-Dichloroaniline
rimonabant
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 24 percent HCl; NaNO2 / H2O / 0 - 5 °C 2: sodium / ethanol / 2.5 h / 0 °C 3: 45 percent / NaOH / ethanol / 1.5 h / Alkaline hydrolysis 4: DMF / CH2Cl2 / 3 h / 20 °C 5: 66 percent / triethylamine / CH2Cl2 / 1.5 h / 20 °C View Scheme |
2,4-dichlorophenyldiazonium chloride
rimonabant
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium / ethanol / 2.5 h / 0 °C 2: 45 percent / NaOH / ethanol / 1.5 h / Alkaline hydrolysis 3: DMF / CH2Cl2 / 3 h / 20 °C 4: 66 percent / triethylamine / CH2Cl2 / 1.5 h / 20 °C View Scheme |
ethyl 1-(2,4-dichlorophenyl)-4-methyl-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylate
rimonabant
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 45 percent / NaOH / ethanol / 1.5 h / Alkaline hydrolysis 2: DMF / CH2Cl2 / 3 h / 20 °C 3: 66 percent / triethylamine / CH2Cl2 / 1.5 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: potassium hydroxide / ethanol / 12 h / 50 °C 2: thionyl chloride / toluene / 2.5 h / 110 °C 3: N-ethyl-N,N-diisopropylamine / chloroform / 4 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: potassium hydroxide; water / methanol / 3 h / Heating / reflux 2: thionyl chloride / toluene / 3 h / Heating / reflux 3: triethylamine / dichloromethane / 3 h / 0 - 20 °C View Scheme |
ethyl [2-acetyl-4-(4-chlorophenyl)-3-methyl-4-oxo]butyrate
rimonabant
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium / ethanol / 2.5 h / 0 °C 2: 45 percent / NaOH / ethanol / 1.5 h / Alkaline hydrolysis 3: DMF / CH2Cl2 / 3 h / 20 °C 4: 66 percent / triethylamine / CH2Cl2 / 1.5 h / 20 °C View Scheme |
1,5-dibromo-pentane
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carbohydrazide
rimonabant
Conditions | Yield |
---|---|
With sodium carbonate In acetonitrile for 45h; Heating / reflux; |
1-Aminopiperidine
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carbonyl chloride
A
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid [5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carbonyl]piperidin-1-yl-amide
B
rimonabant
Conditions | Yield |
---|---|
With potassium carbonate In dichloromethane at 10 - 30℃; Product distribution / selectivity; |
1-Aminopiperidine
ethyl 1-(2,4-dichlorophenyl)-4-methyl-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylate
A
rimonabant acid
B
rimonabant
Conditions | Yield |
---|---|
magnesium chloride In tetrahydrofuran at 80℃; for 2 - 4h; Product distribution / selectivity; | |
magnesium chloride In acetonitrile at 80℃; for 2 - 4h; Product distribution / selectivity; | |
magnesium chloride at 80℃; for 2 - 4h; Product distribution / selectivity; |
5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid methyl ester
1-Aminopiperidine
A
rimonabant acid
B
rimonabant
Conditions | Yield |
---|---|
magnesium chloride In acetonitrile at 80℃; for 2 - 4h; Product distribution / selectivity; |
phenyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylate
1-Aminopiperidine
A
rimonabant acid
B
rimonabant
Conditions | Yield |
---|---|
In acetonitrile at 80℃; for 2 - 4h; Product distribution / selectivity; |
propan-1-ol
rimonabant
Conditions | Yield |
---|---|
at 4 - 20℃; Heating / reflux; | 100% |
at 5 - 50℃; for 5h; |
N-aminopiperidine hydrochloride
rimonabant acid
rimonabant
rimonabant hydrochloride
Conditions | Yield |
---|---|
Stage #1: rimonabant acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; for 6h; Stage #2: N-aminopiperidine hydrochloride With triethylamine In tetrahydrofuran at 60℃; for 1.5h; Stage #3: rimonabant With hydrogenchloride | 92.7% |
1,3-dibromo-propane
rimonabant
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 20℃; for 16h; Reflux; Inert atmosphere; | 70% |
ethyl bromoacetate
rimonabant
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 48h; Reflux; Inert atmosphere; | 55% |
rimonabant
Conditions | Yield |
---|---|
In acetonitrile for 2.5h; Irradiation; | 42% |
rimonabant
A
N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichloro-6-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide
Conditions | Yield |
---|---|
With n-butyllithium; 1,10-Phenanthroline; 1-chloro-2-iodoethane In diethyl ether at -78 - 20℃; | A 17% B 14% |
rimonabant
N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichloro-6-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide
Conditions | Yield |
---|---|
With n-butyllithium; 1-chloro-2-iodoethane In diethyl ether at -15℃; |
rimonabant
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)pyrazole-3-carboxamide hydrate
Conditions | Yield |
---|---|
Stage #1: rimonabant In dichloromethane at 25 - 30℃; for 0.166667h; Stage #2: With water at 25 - 30℃; for 1h; Product distribution / selectivity; | |
With water In acetone at 25 - 50℃; for 6h; Product distribution / selectivity; | |
With water In methanol at 25 - 55℃; for 2h; Product distribution / selectivity; |
rimonabant
butan-1-ol
Conditions | Yield |
---|---|
at 5 - 50℃; for 5h; |
rimonabant
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 17 percent / n-butyllithium; 1-chloro-2-iodoethane; 1,10-phenanthroline / diethyl ether / -78 - 20 °C 2: tritium; Et3N / 10 percent Pd-C / ethanol / 3.5 h View Scheme |
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