As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:172900-83-3
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:172900-83-3
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:172900-83-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:172900-83-3
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryHunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as
Cas:172900-83-3
Min.Order:0 Metric Ton
Negotiable
Type:Manufacturers
inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou
factory?direct?sale Application:healing drugs
Cas:172900-83-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquirygood quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran
Carbamic acid,[3-[[4-(1,1-dimethylethyl)phenyl]methyl]-1-formyl-4-methylpentyl]-,1,1-dimethylethyl ester, [S-(R*,R*)]-Carbamic acid,Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:phar
Cas:172900-83-3
Min.Order:0
Negotiable
Type:Other
inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China
Cas:172900-83-3
Min.Order:0
Negotiable
Type:Trading Company
inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
Our mission is to provide high-quality and innovative products to our customers. By offering a broad range of products, custom synthesis and personalized services, Bide can help scientists speeding up their research in the chemical and pharmaceutical
Cas:172900-83-3
Min.Order:0
Negotiable
Type:Other
inquiry1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G
Cas:172900-83-3
Min.Order:10 Milligram
Negotiable
Type:Lab/Research institutions
inquirywe have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and development production of reagent tens of thousands of species. our aim is quality strives for the survi
Cas:172900-83-3
Min.Order:10 Gram
FOB Price: $1.0
Type:Trading Company
inquiryWe are able to provide you best product with best price. Application:medical intermediate Port:shanghai,ningbo
Cas:172900-83-3
Min.Order:100 Kilogram
Negotiable
Type:Trading Company
inquirytert-Butyl ((2S,4S)-4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-methyl-1-oxohexan-2-yl)carbamate Application:80077214
Cas:172900-83-3
Min.Order:1 Gram
FOB Price: $500.0
Type:Trading Company
inquiryCas:172900-83-3
Min.Order:0
Negotiable
Type:Other
inquiryGood Price, prompt shipment Application:Medical intermediate; Used in organic synthesis
Package:5KG; 1KG; 500G; 100G
Cas:172900-83-3
Min.Order:0
Negotiable
Type:Trading Company
inquiryCas:172900-83-3
Min.Order:0
Negotiable
Type:Trading Company
inquiryR & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates
(2S,4S)-2-{[(tert-butoxy)carbonyl]amino}-4-[4-methoxy-3-(3-methoxypropoxy)benzyl]-5-methylhexan-1-ol
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With sulfur trioxide pyridine complex; triethylamine In dimethyl sulfoxide at 0 - 20℃; for 1h; | 100% |
With sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine at 0 - 20℃; for 1h; | 100% |
With oxalyl dichloride; dimethyl sulfoxide; triethylamine In dichloromethane Swern oxidation; | 89% |
methyl (2S,4S)-2-{[(tert-butoxy)carbonyl]amino}-4-[4-methoxy-3-(3-methoxypropoxy)benzyl]-5-methylhexanoate
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With diisobutylaluminium hydride In toluene at -75℃; for 0.833333h; | |
Multi-step reaction with 2 steps 1: lithium borohydride / tetrahydrofuran / 15 h / 20 °C 2: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / 1 h / 0 - 20 °C View Scheme |
(2R,5S)-3,6-diethoxy-2-isopropyl-5-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-2,5-dihydropyrazine
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: HCl / acetonitrile 2: Et3N 3: NaBH4 / ethanol 4: 89 percent / DMSO; ClC(O)C(O)Cl; Et3N / CH2Cl2 View Scheme |
isovanillin
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 12 steps 1: 98 percent / K2CO3 / acetonitrile 2: NaBH4 / ethanol 3: PBr3 / CH2Cl2 4: 76 percent / LiHMDS / tetrahydrofuran 5: 81 percent / LiOH; H2O2 6: 95 percent / LAH / tetrahydrofuran 7: 97 percent / PPh3; NBS / CH2Cl2 8: 68 percent / n-BuLi 9: HCl / acetonitrile 10: Et3N 11: NaBH4 / ethanol 12: 89 percent / DMSO; ClC(O)C(O)Cl; Et3N / CH2Cl2 View Scheme | |
Multi-step reaction with 11 steps 1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 24 h / 20 °C 2.1: sodium tetrahydroborate; ethanol / 20 °C 3.1: pyridine; phosphorus tribromide / diethyl ether / 3 h / 20 °C 4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / Cooling with acetone-dry ice 4.2: 20 °C / Cooling with acetone-dry ice 5.1: lithium borohydride; water / diethyl ether / 0.67 h / 0 °C 6.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 3 h 7.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / Cooling with acetone-dry ice 7.2: 16.17 h / -78 °C / Cooling with acetone-dry ice 8.1: hydrogenchloride; water / acetonitrile / 3 h / 20 °C 8.2: 0 °C 9.1: dichloromethane / 14 h / 20 °C 10.1: lithium borohydride / tetrahydrofuran / 15 h / 20 °C 11.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / 1 h / 0 - 20 °C View Scheme |
(R)-4-benzyl-3-(3-methylbutyryl)oxazolidin-2-one
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: 76 percent / LiHMDS / tetrahydrofuran 2: 81 percent / LiOH; H2O2 3: 95 percent / LAH / tetrahydrofuran 4: 97 percent / PPh3; NBS / CH2Cl2 5: 68 percent / n-BuLi 6: HCl / acetonitrile 7: Et3N 8: NaBH4 / ethanol 9: 89 percent / DMSO; ClC(O)C(O)Cl; Et3N / CH2Cl2 View Scheme | |
Multi-step reaction with 8 steps 1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / Cooling with acetone-dry ice 1.2: 20 °C / Cooling with acetone-dry ice 2.1: lithium borohydride; water / diethyl ether / 0.67 h / 0 °C 3.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 3 h 4.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / Cooling with acetone-dry ice 4.2: 16.17 h / -78 °C / Cooling with acetone-dry ice 5.1: hydrogenchloride; water / acetonitrile / 3 h / 20 °C 5.2: 0 °C 6.1: dichloromethane / 14 h / 20 °C 7.1: lithium borohydride / tetrahydrofuran / 15 h / 20 °C 8.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / 1 h / 0 - 20 °C View Scheme |
4-methoxy-3-(3-methoxypropoxy)benzaldehyde
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1: NaBH4 / ethanol 2: PBr3 / CH2Cl2 3: 76 percent / LiHMDS / tetrahydrofuran 4: 81 percent / LiOH; H2O2 5: 95 percent / LAH / tetrahydrofuran 6: 97 percent / PPh3; NBS / CH2Cl2 7: 68 percent / n-BuLi 8: HCl / acetonitrile 9: Et3N 10: NaBH4 / ethanol 11: 89 percent / DMSO; ClC(O)C(O)Cl; Et3N / CH2Cl2 View Scheme | |
Multi-step reaction with 10 steps 1.1: sodium tetrahydroborate; ethanol / 20 °C 2.1: pyridine; phosphorus tribromide / diethyl ether / 3 h / 20 °C 3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / Cooling with acetone-dry ice 3.2: 20 °C / Cooling with acetone-dry ice 4.1: lithium borohydride; water / diethyl ether / 0.67 h / 0 °C 5.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 3 h 6.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / Cooling with acetone-dry ice 6.2: 16.17 h / -78 °C / Cooling with acetone-dry ice 7.1: hydrogenchloride; water / acetonitrile / 3 h / 20 °C 7.2: 0 °C 8.1: dichloromethane / 14 h / 20 °C 9.1: lithium borohydride / tetrahydrofuran / 15 h / 20 °C 10.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / 1 h / 0 - 20 °C View Scheme |
(R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutanol
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 97 percent / PPh3; NBS / CH2Cl2 2: 68 percent / n-BuLi 3: HCl / acetonitrile 4: Et3N 5: NaBH4 / ethanol 6: 89 percent / DMSO; ClC(O)C(O)Cl; Et3N / CH2Cl2 View Scheme | |
Multi-step reaction with 6 steps 1.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 3 h 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / Cooling with acetone-dry ice 2.2: 16.17 h / -78 °C / Cooling with acetone-dry ice 3.1: hydrogenchloride; water / acetonitrile / 3 h / 20 °C 3.2: 0 °C 4.1: dichloromethane / 14 h / 20 °C 5.1: lithium borohydride / tetrahydrofuran / 15 h / 20 °C 6.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / 1 h / 0 - 20 °C View Scheme |
(R)-3-[4-methoxy-3-(3-methoxypropoxy)phenyl]-2-(1-methylethyl)propanoic acid
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 95 percent / LAH / tetrahydrofuran 2: 97 percent / PPh3; NBS / CH2Cl2 3: 68 percent / n-BuLi 4: HCl / acetonitrile 5: Et3N 6: NaBH4 / ethanol 7: 89 percent / DMSO; ClC(O)C(O)Cl; Et3N / CH2Cl2 View Scheme |
4-(bromomethyl)-1-methoxy-2-(3-methoxypropoxy)-benzene
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: 76 percent / LiHMDS / tetrahydrofuran 2: 81 percent / LiOH; H2O2 3: 95 percent / LAH / tetrahydrofuran 4: 97 percent / PPh3; NBS / CH2Cl2 5: 68 percent / n-BuLi 6: HCl / acetonitrile 7: Et3N 8: NaBH4 / ethanol 9: 89 percent / DMSO; ClC(O)C(O)Cl; Et3N / CH2Cl2 View Scheme | |
Multi-step reaction with 8 steps 1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / Cooling with acetone-dry ice 1.2: 20 °C / Cooling with acetone-dry ice 2.1: lithium borohydride; water / diethyl ether / 0.67 h / 0 °C 3.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 3 h 4.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / Cooling with acetone-dry ice 4.2: 16.17 h / -78 °C / Cooling with acetone-dry ice 5.1: hydrogenchloride; water / acetonitrile / 3 h / 20 °C 5.2: 0 °C 6.1: dichloromethane / 14 h / 20 °C 7.1: lithium borohydride / tetrahydrofuran / 15 h / 20 °C 8.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / 1 h / 0 - 20 °C View Scheme |
[4-methoxy-3-(3-methoxypropoxy)-phenyl]methanol
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: PBr3 / CH2Cl2 2: 76 percent / LiHMDS / tetrahydrofuran 3: 81 percent / LiOH; H2O2 4: 95 percent / LAH / tetrahydrofuran 5: 97 percent / PPh3; NBS / CH2Cl2 6: 68 percent / n-BuLi 7: HCl / acetonitrile 8: Et3N 9: NaBH4 / ethanol 10: 89 percent / DMSO; ClC(O)C(O)Cl; Et3N / CH2Cl2 View Scheme | |
Multi-step reaction with 9 steps 1.1: pyridine; phosphorus tribromide / diethyl ether / 3 h / 20 °C 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / Cooling with acetone-dry ice 2.2: 20 °C / Cooling with acetone-dry ice 3.1: lithium borohydride; water / diethyl ether / 0.67 h / 0 °C 4.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 3 h 5.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / Cooling with acetone-dry ice 5.2: 16.17 h / -78 °C / Cooling with acetone-dry ice 6.1: hydrogenchloride; water / acetonitrile / 3 h / 20 °C 6.2: 0 °C 7.1: dichloromethane / 14 h / 20 °C 8.1: lithium borohydride / tetrahydrofuran / 15 h / 20 °C 9.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / 1 h / 0 - 20 °C View Scheme |
(R)-4-(2-(bromomethyl)-3-methylbutyl)-1-methoxy-2-(3-methoxypropoxy)benzene
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 68 percent / n-BuLi 2: HCl / acetonitrile 3: Et3N 4: NaBH4 / ethanol 5: 89 percent / DMSO; ClC(O)C(O)Cl; Et3N / CH2Cl2 View Scheme |
(2S,4S)-2-Amino-4-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-5-methyl-hexanoic acid ethyl ester
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Et3N 2: NaBH4 / ethanol 3: 89 percent / DMSO; ClC(O)C(O)Cl; Et3N / CH2Cl2 View Scheme |
ethyl (2S,4S)-2-{[(tert-butoxy)carbonyl]amino}-4-[4-methoxy-3-(3-methoxypropoxy)benzyl]-5-methylhexanoate
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaBH4 / ethanol 2: 89 percent / DMSO; ClC(O)C(O)Cl; Et3N / CH2Cl2 View Scheme |
(4R)-3-{(2R)-2-{[4-methoxy-3-(methoxypropoxy)phenyl]methyl-3-methyl}-1-oxobutyl}-4-(phenylmethyl)oxazolidin-2-one
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 81 percent / LiOH; H2O2 2: 95 percent / LAH / tetrahydrofuran 3: 97 percent / PPh3; NBS / CH2Cl2 4: 68 percent / n-BuLi 5: HCl / acetonitrile 6: Et3N 7: NaBH4 / ethanol 8: 89 percent / DMSO; ClC(O)C(O)Cl; Et3N / CH2Cl2 View Scheme | |
Multi-step reaction with 7 steps 1.1: lithium borohydride; water / diethyl ether / 0.67 h / 0 °C 2.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 3 h 3.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / Cooling with acetone-dry ice 3.2: 16.17 h / -78 °C / Cooling with acetone-dry ice 4.1: hydrogenchloride; water / acetonitrile / 3 h / 20 °C 4.2: 0 °C 5.1: dichloromethane / 14 h / 20 °C 6.1: lithium borohydride / tetrahydrofuran / 15 h / 20 °C 7.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / 1 h / 0 - 20 °C View Scheme |
(R)-4-(2-(iodomethyl)-3-methylbutyl)-1-methoxy-2-(3-methoxypropoxy)benzene
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / Cooling with acetone-dry ice 1.2: 16.17 h / -78 °C / Cooling with acetone-dry ice 2.1: hydrogenchloride; water / acetonitrile / 3 h / 20 °C 2.2: 0 °C 3.1: dichloromethane / 14 h / 20 °C 4.1: lithium borohydride / tetrahydrofuran / 15 h / 20 °C 5.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / 1 h / 0 - 20 °C View Scheme |
isopentanoyl chloride
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / Cooling with acetone-dry ice 1.2: 2.33 h / 0 °C / Cooling with acetone-dry ice 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / Cooling with acetone-dry ice 2.2: 20 °C / Cooling with acetone-dry ice 3.1: lithium borohydride; water / diethyl ether / 0.67 h / 0 °C 4.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 3 h 5.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / Cooling with acetone-dry ice 5.2: 16.17 h / -78 °C / Cooling with acetone-dry ice 6.1: hydrogenchloride; water / acetonitrile / 3 h / 20 °C 6.2: 0 °C 7.1: dichloromethane / 14 h / 20 °C 8.1: lithium borohydride / tetrahydrofuran / 15 h / 20 °C 9.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / 1 h / 0 - 20 °C View Scheme |
methyl (2S,4S)-2-amino-4-[4-methoxy-3-(3-methoxypropoxy)benzyl]-5-methylhexanoate
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: dichloromethane / 14 h / 20 °C 2: lithium borohydride / tetrahydrofuran / 15 h / 20 °C 3: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / 1 h / 0 - 20 °C View Scheme |
(2S,5R)-2,5-dihydro-3,6-dimethoxy-2-{(2S)-2-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-3-methylbutyl}-5-(1-methylethyl)pyrazine
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: hydrogenchloride; water / acetonitrile / 3 h / 20 °C 1.2: 0 °C 2.1: dichloromethane / 14 h / 20 °C 3.1: lithium borohydride / tetrahydrofuran / 15 h / 20 °C 4.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / 1 h / 0 - 20 °C View Scheme |
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
(2S)-(benzyloxymethyl)-3-methyl-butyl bromide
Conditions | Yield |
---|---|
Stage #1: (2S)-(benzyloxymethyl)-3-methyl-butyl bromide With magnesium; ethylene dibromide In tetrahydrofuran at 55℃; for 0.333333h; Stage #2: (1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester In tetrahydrofuran at 20℃; for 3h; Further stages.; | 53% |
With magnesium | |
Stage #1: (2S)-(benzyloxymethyl)-3-methyl-butyl bromide With magnesium; ethylene dibromide In tetrahydrofuran at 55℃; for 0.833333h; Stage #2: (1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester In tetrahydrofuran at 5 - 20℃; for 3h; |
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
tert-butyl (1S,3S)-3-(3-(3-methoxypropoxy)-4-methoxybenzyl)-4-methyl-1-((R)-oxiran-2-yl)pentylcarbamate
Conditions | Yield |
---|---|
Stage #1: trimethylsulfoxonium iodide With sodium hydride In dimethyl sulfoxide at 20℃; for 1h; Stage #2: (1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester In tetrahydrofuran; dimethyl sulfoxide at 20℃; for 1h; | 46% |
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
trimethylsulfoxonium iodide
tert-butyl (1S,3S)-3-(3-(3-methoxypropoxy)-4-methoxybenzyl)-4-methyl-1-((R)-oxiran-2-yl)pentylcarbamate
Conditions | Yield |
---|---|
Stage #1: trimethylsulfoxonium iodide With sodium hydride In dimethyl sulfoxide at 20℃; for 1h; Stage #2: (1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester In tetrahydrofuran; dimethyl sulfoxide at 20℃; for 1h; Product distribution / selectivity; | 46% |
Stage #1: trimethylsulfoxonium iodide With potassium tert-butylate at 20℃; Stage #2: (1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester In tetrahydrofuran; dimethyl sulfoxide at 0℃; for 2h; |
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
methacrylic acid N-(butyl)amide
Conditions | Yield |
---|---|
Stage #1: methacrylic acid N-(butyl)amide With n-butyllithium In tetrahydrofuran; hexane at -78 - 0℃; for 0.5h; Stage #2: With triisopropoxytitanium(IV) chloride In tetrahydrofuran; hexane at -78℃; for 0.916667h; Stage #3: (1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester In tetrahydrofuran; hexane at -78℃; for 1.5h; Further stages.; | A 76 g B 188 g |
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Mg 2: H2 / Pd(OH)2/C 3: TPAP; NMMO View Scheme |
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
tert-butyl {(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl}carbamate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Mg 2: 23 percent / H2 / Pd(OH)2/C 3: 38 percent / TPAP; NMMO View Scheme |
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
((1S,2R,4S)-2-Hydroxy-4-hydroxymethyl-1-{(S)-2-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-3-methyl-butyl}-5-methyl-hexyl)-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Mg 2: H2 / Pd(OH)2/C View Scheme |
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
((1S,2S,4S)-2-hydroxy-4-hydroxymethyl-1-((S)-2-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-3-methyl-butyl)-5-methyl-hexyl)-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Mg 2: 23 percent / H2 / Pd(OH)2/C View Scheme |
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: Mg 2: H2 / Pd(OH)2/C 3: TPAP; NMMO 4: 2-hydroxypyridine; Et3N 5: TMSCl; phenol / CH2Cl2 View Scheme |
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: Mg 2: H2 / Pd(OH)2/C 3: TPAP; NMMO 4: 2-hydroxypyridine; Et3N View Scheme |
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
tert-butyl (3S,5S,6S,8S)-8-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-ylcarbamate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: Mg 2: 23 percent / H2 / Pd(OH)2/C 3: 38 percent / TPAP; NMMO 4: 65 percent / 2-hydroxypyridine; Et3N View Scheme |
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
(2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: Mg 2: 23 percent / H2 / Pd(OH)2/C 3: 38 percent / TPAP; NMMO 4: 65 percent / 2-hydroxypyridine; Et3N 5: TMSCl; phenol / CH2Cl2 View Scheme |
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
propynoic acid ethyl ester
(4S,5S,7S)-5-tert-Butoxycarbonylamino-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnon-2-ynoic acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: propynoic acid ethyl ester With lithium diisopropyl amide In tetrahydrofuran for 0.5h; Stage #2: (1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester In tetrahydrofuran at -78℃; for 1h; |
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
tert-butyl {1(S)-(2-amino-1(S)-hydroxyethyl)-3(S)-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl}carbamate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydride / dimethyl sulfoxide / 1 h / 20 °C 1.2: 1 h / 20 °C 2.1: ammonia; water / methanol / 20 °C View Scheme |
(1S,3S)-{1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydride / dimethyl sulfoxide / 1 h / 20 °C 1.2: 1 h / 20 °C 2.1: acetonitrile / 0.33 h / 90 °C / Microwave View Scheme |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View