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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

High quality 183133-96-2 with best price

Cas:183133-96-2

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White or off-white powder Storage:2-8°C Package:1g/PE bottle;

Good quality Cabazitaxel CAS 183133-96-2 supplied by manufacturer

Cas:183133-96-2

Min.Order:1 Gram

FOB Price: $120.0 / 200.0

Type:Trading Company

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Hubei Vanz Pharm Co.,Ltd

We are manufacture for the materials, and other sarms,steriods ,we also produce, price is very competitive, quality very good. Appearance:white powder Application:Pharmaceutical

Cabazitaxel CAS 183133-96-2

Cas:183133-96-2

Min.Order:1 Gram

FOB Price: $10.0

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Cabazitaxel

Cas:183133-96-2

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Cabazitaxel 183133-96-2 ISO Producer

Cas:183133-96-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Cabazitaxel

Cas:183133-96-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Cabazitaxel Manufacturer/High quality/Best price/In stock

Cas:183133-96-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Cabazitaxel

Cas:183133-96-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Facotry Supply Cabazitaxel CAS: 183133-96-2

Cas:183133-96-2

Min.Order:1 Gram

FOB Price: $200.0

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

cabazitaxel

Cas:183133-96-2

Min.Order:1000 Gram

FOB Price: $500.0

Type:Trading Company

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Hubei DiBo chemical co., LTD

Name:TAX-258 CAS:183133-96-2 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability Prod

Good quality Cabazitaxel CAS 183133-96-2 supplied by manufacturer

Cas:183133-96-2

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Product Name: Cabazitaxel Synonyms: Cabazitaxel;TXD-258;(αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxybenzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11

Cabazitaxel

Cas:183133-96-2

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Cabazitaxel

Cas:183133-96-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 183133-96-2 with best quality

Cas:183133-96-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

cabazitaxel CAS183133-96-2

Cas:183133-96-2

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Chemical Name: Cabazitaxel Cas No.: 183133-96-2 Molecular Formula: C45H57NO14 Molecular Structure: Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25k

Cabazitaxel

Cas:183133-96-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

Cabazitaxel

Cas:183133-96-2

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our

Factory Supply Pharmaceutical Cabazitaxel CAS 183133-96-2

Cas:183133-96-2

Min.Order:10 Gram

Negotiable

Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Factory Price Anti-Cancer Raw Powder CAS 183133-96-2 Cabazitaxel

Cas:183133-96-2

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate

High quality Cabazitaxel 99% with lower price

Cas:183133-96-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

Supply High Quality Cabazitaxel CAS 183133-96-2 For research Use only

Cas:183133-96-2

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE CAS:183133-96-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qu

3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE CAS:183133-96-2

Cas:183133-96-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Cabazitaxel

Cas:183133-96-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Cabazitaxel/ LIDE PHARMA- Factory supply / Best price

Cas:183133-96-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

High Purity Cabazitaxel

Cas:183133-96-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Cabazitaxel

Cas:183133-96-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Triumph International Development Limilted

Appearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:By Sea/Air/Courier Port:Qingdao/Shanghai

Sell/Synthesis Cabazitaxel|183133-96-2 99.9% white powder

Cas:183133-96-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

cabazitaxel

Cas:183133-96-2

Min.Order:1 Kilogram

FOB Price: $30.0 / 50.0

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Cabazitaxel

Cas:183133-96-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

XRP-6258 Cabazitaxel 183133-96-2

Cas:183133-96-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

1-hydroxy-7β,10β-di-methoxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-trethylsilyloxy-3-phenylpropanoate}
1380584-07-5

1-hydroxy-7β,10β-di-methoxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-trethylsilyloxy-3-phenylpropanoate}

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
With pyridine; hydrogen fluoride In acetonitrile at -8 - 0℃; for 23.5h;97%
With pyridine; hydrogen fluoride In acetonitrile at -8 - 0℃; for 23.5h;97%
With toluene-4-sulfonic acid In tetrahydrofuran; methanol at 0 - 5℃; for 1h;90%
C49H65NO15

C49H65NO15

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
With methanol at 20℃; for 2h;96.1%
2’-(1-ethoxyethyl)cabazitaxel
1357159-78-4

2’-(1-ethoxyethyl)cabazitaxel

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; ethanol at -8 - 0℃; for 23.5h;95%
With hydrogenchloride In tetrahydrofuran; ethanol at -8 - 0℃; for 23.5h;95%
(2α,5β,7β,10β,13α)-4-(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-[2-methoxy-2-prop-2-yl oxy]-3-phenylpropionyl}oxy)-1-hydroxy-7,10-dimethoxy-9-oxo-5,20-epoxy-11-ene-2-yl benzoate

(2α,5β,7β,10β,13α)-4-(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-[2-methoxy-2-prop-2-yl oxy]-3-phenylpropionyl}oxy)-1-hydroxy-7,10-dimethoxy-9-oxo-5,20-epoxy-11-ene-2-yl benzoate

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; water at 20 - 25℃; for 3h;90%
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxen-13α-yl (2R,4S,5S)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate
1354900-66-5

4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxen-13α-yl (2R,4S,5S)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
With hydrogenchloride In ethanol at -5 - -2℃; Inert atmosphere;89%
With hydrogenchloride; water In ethyl acetate at 0 - 5℃;
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-amino-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-amino-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
With potassium carbonate In dichloromethane; water at 20℃; for 4h;85.7%
In methanol at 25 - 35℃; for 14h;40 g
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β-hydroxy-7β,10β-dimethoxy-9-oxo-11-taxene-13α-yl (2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate
183133-95-1

4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β-hydroxy-7β,10β-dimethoxy-9-oxo-11-taxene-13α-yl (2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
With hydrogenchloride; water In methanol at 20℃;83%
With hydrogenchloride In 2-methyltetrahydrofuran; methanol; water at 20℃; for 0.5h;81%
With hydrogenchloride In ethanol at 0 - 5℃; Concentration; Inert atmosphere;
With hydrogenchloride In methanol; dichloromethane; water at 0℃; for 1h;
2'-(tetrahydrpyran)cabazitaxel
1372883-35-6

2'-(tetrahydrpyran)cabazitaxel

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
With acetic acid In tetrahydrofuran; water at 50℃; for 4h; Inert atmosphere;83%
With acetic acid In tetrahydrofuran; water at 50℃; for 4h; Inert atmosphere;83%
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxen-13α-yl (2R,4S,5S)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate

4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxen-13α-yl (2R,4S,5S)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
With hydrogenchloride In ethyl acetate at 0℃;71%
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxen-13α-yl-(2S,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate

4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxen-13α-yl-(2S,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
With hydrogenchloride In ethyl acetate at 0℃;71%
7,10-O-demethyl-7,10-O-(methylthiomethyl)cabazitaxel

7,10-O-demethyl-7,10-O-(methylthiomethyl)cabazitaxel

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
With hydrogen In ethanol at 50℃; under 2280.15 Torr; for 12h;66%
10-deacetylbaccatin III
32981-86-5

10-deacetylbaccatin III

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydride; caesium bromide / N,N-dimethyl-formamide; tetrahydrofuran; mineral oil / 2 h / -20 - 20 °C / Inert atmosphere
2: sodium hydride; iron(III) chloride / tetrahydrofuran; mineral oil / 2.5 h / -15 - 20 °C / Inert atmosphere
3: hydrogenchloride / water; methanol / -5 - 5 °C / pH 1 - 2
View Scheme
Multi-step reaction with 3 steps
1: sodium hydride / tetrahydrofuran; mineral oil / 45 °C
2: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere
3: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium hydride / tetrahydrofuran; mineral oil / 45 °C
2: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere
3: toluene-4-sulfonic acid / butan-1-ol / 1 h / 50 °C
View Scheme
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
183133-94-0

4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene

tert-butyl (3R,4S)-2-oxo-4-phenyl-3-(triethylsilyloxy)azetidine-1-carboxylate
149198-47-0

tert-butyl (3R,4S)-2-oxo-4-phenyl-3-(triethylsilyloxy)azetidine-1-carboxylate

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere
2: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C
View Scheme
7,13-diacetyl baccatin III
92950-44-2

7,13-diacetyl baccatin III

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: hydrazine hydrate / N,N-dimethyl-formamide / 20 h / 0 °C / Inert atmosphere
2: acetic anhydride; acetic acid / 120 h / 23 °C / Inert atmosphere
3: water / Raney nickel / methanol / 23 °C
4: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere
5: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere
6: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C
View Scheme
Multi-step reaction with 6 steps
1: hydrazine hydrate / N,N-dimethyl-formamide / 20 h / 0 °C / Inert atmosphere
2: acetic anhydride; acetic acid / 120 h / 23 °C / Inert atmosphere
3: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere
4: water / Raney nickel / methanol / 23 °C
5: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere
6: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C
View Scheme
Multi-step reaction with 6 steps
1: hydrazine hydrate / N,N-dimethyl-formamide / 20 h / 0 °C / Inert atmosphere
2: acetic anhydride; acetic acid / 120 h / 23 °C / Inert atmosphere
3: water / Raney nickel / methanol / 23 °C
4: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere
5: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere
6: toluene-4-sulfonic acid / butan-1-ol / 1 h / 50 °C
View Scheme
Multi-step reaction with 6 steps
1: hydrazine hydrate / N,N-dimethyl-formamide / 20 h / 0 °C / Inert atmosphere
2: acetic anhydride; acetic acid / 120 h / 23 °C / Inert atmosphere
3: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere
4: water / Raney nickel / methanol / 23 °C
5: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere
6: toluene-4-sulfonic acid / butan-1-ol / 1 h / 50 °C
View Scheme
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
183133-94-0

4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene

C17H23NO5

C17H23NO5

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere
2: toluene-4-sulfonic acid / butan-1-ol / 1 h / 50 °C
View Scheme
13-acetyl-10-deacetyl baccatin III
110258-96-3

13-acetyl-10-deacetyl baccatin III

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: acetic anhydride; acetic acid / 120 h / 23 °C / Inert atmosphere
2: water / Raney nickel / methanol / 23 °C
3: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere
4: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere
5: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C
View Scheme
Multi-step reaction with 5 steps
1: acetic anhydride; acetic acid / 120 h / 23 °C / Inert atmosphere
2: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere
3: water / Raney nickel / methanol / 23 °C
4: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere
5: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C
View Scheme
Multi-step reaction with 5 steps
1: acetic anhydride; acetic acid / 120 h / 23 °C / Inert atmosphere
2: water / Raney nickel / methanol / 23 °C
3: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere
4: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere
5: toluene-4-sulfonic acid / butan-1-ol / 1 h / 50 °C
View Scheme
Multi-step reaction with 5 steps
1: acetic anhydride; acetic acid / 120 h / 23 °C / Inert atmosphere
2: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere
3: water / Raney nickel / methanol / 23 °C
4: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere
5: toluene-4-sulfonic acid / butan-1-ol / 1 h / 50 °C
View Scheme
13-acetyl-7,10-methylthiomethyl-10-DAB
1402820-66-9

13-acetyl-7,10-methylthiomethyl-10-DAB

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: water / Raney nickel / methanol / 23 °C
2: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere
3: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere
4: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C
View Scheme
Multi-step reaction with 4 steps
1: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere
2: water / Raney nickel / methanol / 23 °C
3: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere
4: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C
View Scheme
Multi-step reaction with 4 steps
1: water / Raney nickel / methanol / 23 °C
2: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere
3: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere
4: toluene-4-sulfonic acid / butan-1-ol / 1 h / 50 °C
View Scheme
Multi-step reaction with 4 steps
1: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere
2: water / Raney nickel / methanol / 23 °C
3: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere
4: toluene-4-sulfonic acid / butan-1-ol / 1 h / 50 °C
View Scheme
7,10-methylthiomethyl-10-deacetylbaccatin III
709673-79-0

7,10-methylthiomethyl-10-deacetylbaccatin III

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: water / Raney nickel / methanol / 23 °C
2: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere
3: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C
View Scheme
Multi-step reaction with 3 steps
1: water / Raney nickel / methanol / 23 °C
2: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere
3: toluene-4-sulfonic acid / butan-1-ol / 1 h / 50 °C
View Scheme
Multi-step reaction with 3 steps
1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -50 °C / Inert atmosphere
2: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / pH 7 / Inert atmosphere
3: hydrogen / ethanol / 12 h / 50 °C / 2280.15 Torr
View Scheme
13-acetyl-7,10-dimethoxy-10-DAB
1402820-67-0

13-acetyl-7,10-dimethoxy-10-DAB

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere
2: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere
3: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C
View Scheme
Multi-step reaction with 3 steps
1: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere
2: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere
3: toluene-4-sulfonic acid / butan-1-ol / 1 h / 50 °C
View Scheme
C48H63NO15

C48H63NO15

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
With toluene-4-sulfonic acid In butan-1-ol at 50℃; for 1h; Product distribution / selectivity;
7-triethylsilyl-10-deacetylbaccatin III
115437-18-8

7-triethylsilyl-10-deacetylbaccatin III

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 - 20 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
3: potassium hydride / tetrahydrofuran / 0 - 20 °C
4: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran
5: water; hydrogenchloride / methanol / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: sodium hydride / N,N-dimethyl acetamide / -15 - -5 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 25 °C
3: sodium hydride / N,N-dimethyl acetamide / 1 h / -15 - -5 °C
4: dmap / tetrahydrofuran / 0.5 h / 20 - 30 °C
5: hydrogenchloride / ethyl acetate / 0 °C
View Scheme
Multi-step reaction with 6 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -40 °C
1.2: 0 - 20 °C
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 23 °C
3.1: pyridine / dichloromethane / 20 °C
4.1: hydrogen / N,N-dimethyl-formamide / 15 h / 20 °C / 2584.17 Torr
5.1: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 2 h / 20 °C
6.1: hydrogenchloride / methanol; water; 2-methyltetrahydrofuran / 0.5 h / 20 °C
View Scheme
4α-acetoxy-2α-benzoyIoxy-5β,20-epoxy-1β,13α-dihydroxy-10β-methoxy-9-oxo-7β-triethylsilyloxy-11-taxene
160084-70-8

4α-acetoxy-2α-benzoyIoxy-5β,20-epoxy-1β,13α-dihydroxy-10β-methoxy-9-oxo-7β-triethylsilyloxy-11-taxene

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
2: potassium hydride / tetrahydrofuran / 0 - 20 °C
3: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran
4: water; hydrogenchloride / methanol / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 25 °C
2: sodium hydride / N,N-dimethyl acetamide / 1 h / -15 - -5 °C
3: dmap / tetrahydrofuran / 0.5 h / 20 - 30 °C
4: hydrogenchloride / ethyl acetate / 0 °C
View Scheme
Multi-step reaction with 5 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 23 °C
2: pyridine / dichloromethane / 20 °C
3: hydrogen / N,N-dimethyl-formamide / 15 h / 20 °C / 2584.17 Torr
4: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 2 h / 20 °C
5: hydrogenchloride / methanol; water; 2-methyltetrahydrofuran / 0.5 h / 20 °C
View Scheme
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-10β-methoxy-9-oxo-1β,13α,7β-trihydroxy-11-taxene
183133-97-3

4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-10β-methoxy-9-oxo-1β,13α,7β-trihydroxy-11-taxene

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium hydride / tetrahydrofuran / 0 - 20 °C
2: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran
3: water; hydrogenchloride / methanol / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium hydride / N,N-dimethyl acetamide / 1 h / -15 - -5 °C
2: dmap / tetrahydrofuran / 0.5 h / 20 - 30 °C
3: hydrogenchloride / ethyl acetate / 0 °C
View Scheme
Multi-step reaction with 4 steps
1: pyridine / dichloromethane / 20 °C
2: hydrogen / N,N-dimethyl-formamide / 15 h / 20 °C / 2584.17 Torr
3: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 2 h / 20 °C
4: hydrogenchloride / methanol; water; 2-methyltetrahydrofuran / 0.5 h / 20 °C
View Scheme
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
183133-94-0

4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran
2: water; hydrogenchloride / methanol / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: dmap / tetrahydrofuran / 0.5 h / 20 - 30 °C
2: hydrogenchloride / ethyl acetate / 0 °C
View Scheme
Multi-step reaction with 2 steps
1: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 2 h / 20 °C
2: hydrogenchloride / methanol; water; 2-methyltetrahydrofuran / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 5 h / 60 °C
2: formic acid / 4 h / 20 °C
3: methanol / 14 h / 25 - 35 °C
View Scheme
Multi-step reaction with 2 steps
1: dicyclohexyl-carbodiimide; dmap / ethyl acetate / 3 h / 20 °C
2: hydrogenchloride / dichloromethane; methanol; water / 1 h / 0 °C
View Scheme
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,10β-dihydroxy-9-oxo-7β,13α-di(triethylsilyloxy)-11-taxene
183133-99-5

4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,10β-dihydroxy-9-oxo-7β,13α-di(triethylsilyloxy)-11-taxene

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: sodium hydride / tetrahydrofuran / -5 - 0 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere
3: sodium hydride / tetrahydrofuran / -5 - 0 °C
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere
5: dmap / tetrahydrofuran / 0.5 h / 20 - 30 °C
6: hydrogenchloride / ethyl acetate / 0 °C
View Scheme
Multi-step reaction with 6 steps
1: sodium hydride / tetrahydrofuran / -5 - 0 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere
3: sodium hydride / -5 - 0 °C
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere
5: dmap; diisopropyl-carbodiimide / tetrahydrofuran / 20 - 30 °C
6: hydrogenchloride / ethyl acetate / 0 °C
View Scheme
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β-hydroxy-9-oxo-10β-methoxy-7β,13α-di(triethylsilyloxy)-11-taxene
183133-98-4

4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β-hydroxy-9-oxo-10β-methoxy-7β,13α-di(triethylsilyloxy)-11-taxene

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere
2: sodium hydride / tetrahydrofuran / -5 - 0 °C
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere
4: dmap / tetrahydrofuran / 0.5 h / 20 - 30 °C
5: hydrogenchloride / ethyl acetate / 0 °C
View Scheme
Multi-step reaction with 5 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere
2: sodium hydride / -5 - 0 °C
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere
4: dmap; diisopropyl-carbodiimide / tetrahydrofuran / 20 - 30 °C
5: hydrogenchloride / ethyl acetate / 0 °C
View Scheme
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,7β-dihydroxy-9-oxo-10β-methoxy-13α-triethylsilyloxy-11-taxene
1433749-82-6

4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,7β-dihydroxy-9-oxo-10β-methoxy-13α-triethylsilyloxy-11-taxene

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydride / tetrahydrofuran / -5 - 0 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere
3: dmap / tetrahydrofuran / 0.5 h / 20 - 30 °C
4: hydrogenchloride / ethyl acetate / 0 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium hydride / -5 - 0 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere
3: dmap; diisopropyl-carbodiimide / tetrahydrofuran / 20 - 30 °C
4: hydrogenchloride / ethyl acetate / 0 °C
View Scheme
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β-hydroxy-7β,10β-dimethoxy-9-oxo-13-(triethylsilyloxy)-11-taxene
1396601-24-3

4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β-hydroxy-7β,10β-dimethoxy-9-oxo-13-(triethylsilyloxy)-11-taxene

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere
2: dmap / tetrahydrofuran / 0.5 h / 20 - 30 °C
3: hydrogenchloride / ethyl acetate / 0 °C
View Scheme
Multi-step reaction with 3 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere
2: dmap; diisopropyl-carbodiimide / tetrahydrofuran / 20 - 30 °C
3: hydrogenchloride / ethyl acetate / 0 °C
View Scheme
2′-O-(tert-butyldimethylsilyl) cabazitaxel
1352816-81-9

2′-O-(tert-butyldimethylsilyl) cabazitaxel

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
With pyridine; hydrogen fluoride In acetonitrile at -8 - 0℃; for 23.5h;
With pyridine; hydrogenchloride In acetonitrile at -8 - -3℃; for 1.5h;
2’-(triethylsilyl)-7,10-(trichloroethoxycarbonyl)docetaxel
152089-14-0

2’-(triethylsilyl)-7,10-(trichloroethoxycarbonyl)docetaxel

carbazitaxel
183133-96-2

carbazitaxel

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: zinc; ammonium chloride / methanol; water / 4 h / 35 - 40 °C
2: n-butyllithium / tetrahydrofuran / 1 h / -10 - -5 °C
3: hydrogen fluoride; pyridine / acetonitrile / 23.5 h / -8 - 0 °C
View Scheme
Multi-step reaction with 3 steps
1: zinc; ammonium chloride / methanol / 1 h / 20 °C
2: sodium hydride / 1 h / -10 - -5 °C
3: pyridine; hydrogen fluoride / acetonitrile / 23.5 h / -8 - 0 °C
View Scheme
4-nitrophenyl 2-(2-(pyridin-2-yl)disulfanyl)ethyl carbonate
874302-76-8

4-nitrophenyl 2-(2-(pyridin-2-yl)disulfanyl)ethyl carbonate

carbazitaxel
183133-96-2

carbazitaxel

cabazitaxel 2-(2-pyridyldithio)ethylcarbonate

cabazitaxel 2-(2-pyridyldithio)ethylcarbonate

Conditions
ConditionsYield
With dmap In dichloromethane at 20℃;99%
With dmap In dichloromethane at 20℃;99%
With dmap In dichloromethane at 20℃;99%
carbazitaxel
183133-96-2

carbazitaxel

N-Cbz-Ala
1142-20-7

N-Cbz-Ala

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-2-((((benzyloxy)carbonyl)-L-alanyl)oxy)-3-((tert-butoxycarbonyl)amino)-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-2-((((benzyloxy)carbonyl)-L-alanyl)oxy)-3-((tert-butoxycarbonyl)amino)-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;99%
succinic acid anhydride
108-30-5

succinic acid anhydride

carbazitaxel
183133-96-2

carbazitaxel

cabazitaxel-2′-succinyl
1375468-12-4

cabazitaxel-2′-succinyl

Conditions
ConditionsYield
With pyridine; dmap at 25℃; for 3h;98%
With triethylamine In dichloromethane for 4h;87.3%
With pyridine; potassium hydroxide at 30℃; Inert atmosphere;80%
With dmap In dichloromethane at 20℃;
With dmap In dichloromethane at 20℃;
1,4-dioxane-2,6-dione
4480-83-5

1,4-dioxane-2,6-dione

carbazitaxel
183133-96-2

carbazitaxel

diglycolyl-cabazitaxel
1375468-21-5

diglycolyl-cabazitaxel

Conditions
ConditionsYield
With dmap In dichloromethane at 25℃; Inert atmosphere;96%
With dmap In dichloromethane; acetone at 22℃; Inert atmosphere;5.04 g
carbazitaxel
183133-96-2

carbazitaxel

10-{[(1R,3aS,5aR,5bR,9S,11aR)-3a-(methoxycarbonyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yl]oxy}-10-oxodecanoic acid

10-{[(1R,3aS,5aR,5bR,9S,11aR)-3a-(methoxycarbonyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yl]oxy}-10-oxodecanoic acid

C86H121NO19

C86H121NO19

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 25℃; Inert atmosphere;95%
carbazitaxel
183133-96-2

carbazitaxel

monosuccinate monohexanoate cisplatin(IV)
1613484-34-6

monosuccinate monohexanoate cisplatin(IV)

C55H77Cl2N3O19Pt

C55H77Cl2N3O19Pt

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 16h; Inert atmosphere;94%
carbazitaxel
183133-96-2

carbazitaxel

2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-hexanoic acid
55750-53-3

2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-hexanoic acid

C55H68N2O17

C55H68N2O17

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 72h;93%
carbazitaxel
183133-96-2

carbazitaxel

6-(benzyloxycarbonylamino)hexanoic acid
1947-00-8

6-(benzyloxycarbonylamino)hexanoic acid

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-2-((6-(((benzyloxy)carbonyl)amino)hexanoyl)oxy)-3-((tertbutoxycarbonyl)amino)-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
1308398-77-7

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-2-((6-(((benzyloxy)carbonyl)amino)hexanoyl)oxy)-3-((tertbutoxycarbonyl)amino)-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;92%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at -5 - 2℃; for 33h; Product distribution / selectivity;
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at -5 - 0℃; for 35h;
carbazitaxel
183133-96-2

carbazitaxel

C35H52O23

C35H52O23

C80H107NO36

C80H107NO36

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 45℃;91.5%
carbazitaxel
183133-96-2

carbazitaxel

4-Nitrophenyl chloroformate
7693-46-1

4-Nitrophenyl chloroformate

cabazitaxel-2’-p-nitrophenylcarbonate
1616776-04-5

cabazitaxel-2’-p-nitrophenylcarbonate

Conditions
ConditionsYield
With pyridine In dichloromethane at -40℃; for 1h;91%
With pyridine In dichloromethane at -40℃; for 2h;80%
With pyridine In dichloromethane at -40℃; for 2h;80%
With pyridine In dichloromethane at -40℃; for 2h;80%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃; for 5h;61.3%
carbazitaxel
183133-96-2

carbazitaxel

linoleic acid
60-33-3

linoleic acid

C63H87NO15

C63H87NO15

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃;91%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride
carbazitaxel
183133-96-2

carbazitaxel

N-(Benzyloxycarbonyl)glycine
1138-80-3

N-(Benzyloxycarbonyl)glycine

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-2-((((benzyloxy)carbonyl)glycyl)oxy)-3-((tert-butoxycarbonyl)amino)-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
1308398-68-6

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-2-((((benzyloxy)carbonyl)glycyl)oxy)-3-((tert-butoxycarbonyl)amino)-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;90%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at -5 - 2℃; for 33h; Product distribution / selectivity;
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at -5 - 2℃; for 34h;
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at -5 - -2℃;
carbazitaxel
183133-96-2

carbazitaxel

acetic acid
64-19-7

acetic acid

C47H59NO15

C47H59NO15

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃;90%
2,2'-oxybis-acetic acid
110-99-6

2,2'-oxybis-acetic acid

carbazitaxel
183133-96-2

carbazitaxel

diglycolyl-cabazitaxel
1375468-21-5

diglycolyl-cabazitaxel

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 1.5h;88.5%
carbazitaxel
183133-96-2

carbazitaxel

(9Z,12Z,15Z)-octadeca-9-12,15-trienoic acid
463-40-1

(9Z,12Z,15Z)-octadeca-9-12,15-trienoic acid

C63H85NO15

C63H85NO15

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃;87%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride
carbazitaxel
183133-96-2

carbazitaxel

C65H92O43

C65H92O43

C110H147NO56

C110H147NO56

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 45℃;83.6%
carbazitaxel
183133-96-2

carbazitaxel

C18H24Cl3NO4

C18H24Cl3NO4

C63H80Cl2N2O18

C63H80Cl2N2O18

Conditions
ConditionsYield
With triethylamine In chloroform at 20℃;83.5%
4-(pyridin-2-yldisulfanyl) butyric acid
250266-79-6

4-(pyridin-2-yldisulfanyl) butyric acid

carbazitaxel
183133-96-2

carbazitaxel

cabazitaxel butyrate pyridyldisulfide
1616776-02-3

cabazitaxel butyrate pyridyldisulfide

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane; water; acetonitrile at 20℃; for 16h;83%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h;83%
carbazitaxel
183133-96-2

carbazitaxel

hexandiol isopropenyl ether

hexandiol isopropenyl ether

C60H89NO16Si

C60H89NO16Si

Conditions
ConditionsYield
With dichloro-acetic acid In dichloromethane at 20℃; for 4h; Inert atmosphere;79%
carbazitaxel
183133-96-2

carbazitaxel

cis-Octadecenoic acid
112-80-1

cis-Octadecenoic acid

C63H89NO15

C63H89NO15

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃;76%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride
carbazitaxel
183133-96-2

carbazitaxel

C50H100O24

C50H100O24

C95H157NO38

C95H157NO38

Conditions
ConditionsYield
With dichloro-acetic acid In dichloromethane at 20℃; for 4h; Inert atmosphere;73%
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