Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
Cas:183133-96-2
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White or off-white powder Storage:2-8°C Package:1g/PE bottle;
Cas:183133-96-2
Min.Order:1 Gram
FOB Price: $120.0 / 200.0
Type:Trading Company
inquiryWe are manufacture for the materials, and other sarms,steriods ,we also produce, price is very competitive, quality very good. Appearance:white powder Application:Pharmaceutical
Cas:183133-96-2
Min.Order:1 Gram
FOB Price: $10.0
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:183133-96-2
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:183133-96-2
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:183133-96-2
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:183133-96-2
Min.Order:1 Gram
FOB Price: $200.0
Type:Trading Company
inquirychengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res
Name:TAX-258 CAS:183133-96-2 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability Prod
Cas:183133-96-2
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryProduct Name: Cabazitaxel Synonyms: Cabazitaxel;TXD-258;(αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxybenzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11
Cas:183133-96-2
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:183133-96-2
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:183133-96-2
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:183133-96-2
Min.Order:1 Kilogram
FOB Price: $7.0 / 9.0
Type:Trading Company
inquiryChemical Name: Cabazitaxel Cas No.: 183133-96-2 Molecular Formula: C45H57NO14 Molecular Structure: Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25k
1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;
Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our
Cas:183133-96-2
Min.Order:10 Gram
Negotiable
Type:Other
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:183133-96-2
Min.Order:1 Kilogram
FOB Price: $200.0 / 400.0
Type:Trading Company
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate
Cas:183133-96-2
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryAbout Product Details Items Specifications Test Results Appearance White to white crystalline powde
Cas:183133-96-2
Min.Order:1 Gram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiry3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE CAS:183133-96-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qu
Cas:183133-96-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:183133-96-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
Cas:183133-96-2
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Appearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:By Sea/Air/Courier Port:Qingdao/Shanghai
Cas:183133-96-2
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures
Cas:183133-96-2
Min.Order:1 Kilogram
FOB Price: $30.0 / 50.0
Type:Lab/Research institutions
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:183133-96-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1-hydroxy-7β,10β-di-methoxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-trethylsilyloxy-3-phenylpropanoate}
carbazitaxel
Conditions | Yield |
---|---|
With pyridine; hydrogen fluoride In acetonitrile at -8 - 0℃; for 23.5h; | 97% |
With pyridine; hydrogen fluoride In acetonitrile at -8 - 0℃; for 23.5h; | 97% |
With toluene-4-sulfonic acid In tetrahydrofuran; methanol at 0 - 5℃; for 1h; | 90% |
carbazitaxel
Conditions | Yield |
---|---|
With methanol at 20℃; for 2h; | 96.1% |
2’-(1-ethoxyethyl)cabazitaxel
carbazitaxel
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran; ethanol at -8 - 0℃; for 23.5h; | 95% |
With hydrogenchloride In tetrahydrofuran; ethanol at -8 - 0℃; for 23.5h; | 95% |
carbazitaxel
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran; water at 20 - 25℃; for 3h; | 90% |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxen-13α-yl (2R,4S,5S)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate
carbazitaxel
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol at -5 - -2℃; Inert atmosphere; | 89% |
With hydrogenchloride; water In ethyl acetate at 0 - 5℃; |
Conditions | Yield |
---|---|
With potassium carbonate In dichloromethane; water at 20℃; for 4h; | 85.7% |
In methanol at 25 - 35℃; for 14h; | 40 g |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β-hydroxy-7β,10β-dimethoxy-9-oxo-11-taxene-13α-yl (2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate
carbazitaxel
Conditions | Yield |
---|---|
With hydrogenchloride; water In methanol at 20℃; | 83% |
With hydrogenchloride In 2-methyltetrahydrofuran; methanol; water at 20℃; for 0.5h; | 81% |
With hydrogenchloride In ethanol at 0 - 5℃; Concentration; Inert atmosphere; | |
With hydrogenchloride In methanol; dichloromethane; water at 0℃; for 1h; |
2'-(tetrahydrpyran)cabazitaxel
carbazitaxel
Conditions | Yield |
---|---|
With acetic acid In tetrahydrofuran; water at 50℃; for 4h; Inert atmosphere; | 83% |
With acetic acid In tetrahydrofuran; water at 50℃; for 4h; Inert atmosphere; | 83% |
carbazitaxel
Conditions | Yield |
---|---|
With hydrogenchloride In ethyl acetate at 0℃; | 71% |
carbazitaxel
Conditions | Yield |
---|---|
With hydrogenchloride In ethyl acetate at 0℃; | 71% |
carbazitaxel
Conditions | Yield |
---|---|
With hydrogen In ethanol at 50℃; under 2280.15 Torr; for 12h; | 66% |
10-deacetylbaccatin III
carbazitaxel
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydride; caesium bromide / N,N-dimethyl-formamide; tetrahydrofuran; mineral oil / 2 h / -20 - 20 °C / Inert atmosphere 2: sodium hydride; iron(III) chloride / tetrahydrofuran; mineral oil / 2.5 h / -15 - 20 °C / Inert atmosphere 3: hydrogenchloride / water; methanol / -5 - 5 °C / pH 1 - 2 View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydride / tetrahydrofuran; mineral oil / 45 °C 2: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere 3: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydride / tetrahydrofuran; mineral oil / 45 °C 2: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere 3: toluene-4-sulfonic acid / butan-1-ol / 1 h / 50 °C View Scheme |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
tert-butyl (3R,4S)-2-oxo-4-phenyl-3-(triethylsilyloxy)azetidine-1-carboxylate
carbazitaxel
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere 2: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C View Scheme |
7,13-diacetyl baccatin III
carbazitaxel
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: hydrazine hydrate / N,N-dimethyl-formamide / 20 h / 0 °C / Inert atmosphere 2: acetic anhydride; acetic acid / 120 h / 23 °C / Inert atmosphere 3: water / Raney nickel / methanol / 23 °C 4: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere 5: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere 6: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 6 steps 1: hydrazine hydrate / N,N-dimethyl-formamide / 20 h / 0 °C / Inert atmosphere 2: acetic anhydride; acetic acid / 120 h / 23 °C / Inert atmosphere 3: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere 4: water / Raney nickel / methanol / 23 °C 5: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere 6: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 6 steps 1: hydrazine hydrate / N,N-dimethyl-formamide / 20 h / 0 °C / Inert atmosphere 2: acetic anhydride; acetic acid / 120 h / 23 °C / Inert atmosphere 3: water / Raney nickel / methanol / 23 °C 4: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere 5: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere 6: toluene-4-sulfonic acid / butan-1-ol / 1 h / 50 °C View Scheme | |
Multi-step reaction with 6 steps 1: hydrazine hydrate / N,N-dimethyl-formamide / 20 h / 0 °C / Inert atmosphere 2: acetic anhydride; acetic acid / 120 h / 23 °C / Inert atmosphere 3: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere 4: water / Raney nickel / methanol / 23 °C 5: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere 6: toluene-4-sulfonic acid / butan-1-ol / 1 h / 50 °C View Scheme |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
carbazitaxel
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere 2: toluene-4-sulfonic acid / butan-1-ol / 1 h / 50 °C View Scheme |
13-acetyl-10-deacetyl baccatin III
carbazitaxel
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: acetic anhydride; acetic acid / 120 h / 23 °C / Inert atmosphere 2: water / Raney nickel / methanol / 23 °C 3: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere 4: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere 5: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 5 steps 1: acetic anhydride; acetic acid / 120 h / 23 °C / Inert atmosphere 2: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere 3: water / Raney nickel / methanol / 23 °C 4: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere 5: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 5 steps 1: acetic anhydride; acetic acid / 120 h / 23 °C / Inert atmosphere 2: water / Raney nickel / methanol / 23 °C 3: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere 4: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere 5: toluene-4-sulfonic acid / butan-1-ol / 1 h / 50 °C View Scheme | |
Multi-step reaction with 5 steps 1: acetic anhydride; acetic acid / 120 h / 23 °C / Inert atmosphere 2: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere 3: water / Raney nickel / methanol / 23 °C 4: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere 5: toluene-4-sulfonic acid / butan-1-ol / 1 h / 50 °C View Scheme |
13-acetyl-7,10-methylthiomethyl-10-DAB
carbazitaxel
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: water / Raney nickel / methanol / 23 °C 2: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere 3: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere 4: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 4 steps 1: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere 2: water / Raney nickel / methanol / 23 °C 3: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere 4: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 4 steps 1: water / Raney nickel / methanol / 23 °C 2: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere 3: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere 4: toluene-4-sulfonic acid / butan-1-ol / 1 h / 50 °C View Scheme | |
Multi-step reaction with 4 steps 1: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere 2: water / Raney nickel / methanol / 23 °C 3: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere 4: toluene-4-sulfonic acid / butan-1-ol / 1 h / 50 °C View Scheme |
7,10-methylthiomethyl-10-deacetylbaccatin III
carbazitaxel
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: water / Raney nickel / methanol / 23 °C 2: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere 3: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 3 steps 1: water / Raney nickel / methanol / 23 °C 2: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere 3: toluene-4-sulfonic acid / butan-1-ol / 1 h / 50 °C View Scheme | |
Multi-step reaction with 3 steps 1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -50 °C / Inert atmosphere 2: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / pH 7 / Inert atmosphere 3: hydrogen / ethanol / 12 h / 50 °C / 2280.15 Torr View Scheme |
13-acetyl-7,10-dimethoxy-10-DAB
carbazitaxel
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere 2: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere 3: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 3 steps 1: hydrazine hydrate / N,N-dimethyl-formamide / 18 h / 23 °C / Inert atmosphere 2: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere 3: toluene-4-sulfonic acid / butan-1-ol / 1 h / 50 °C View Scheme |
carbazitaxel
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In butan-1-ol at 50℃; for 1h; Product distribution / selectivity; |
7-triethylsilyl-10-deacetylbaccatin III
carbazitaxel
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 - 20 °C 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C 3: potassium hydride / tetrahydrofuran / 0 - 20 °C 4: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran 5: water; hydrogenchloride / methanol / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1: sodium hydride / N,N-dimethyl acetamide / -15 - -5 °C 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 25 °C 3: sodium hydride / N,N-dimethyl acetamide / 1 h / -15 - -5 °C 4: dmap / tetrahydrofuran / 0.5 h / 20 - 30 °C 5: hydrogenchloride / ethyl acetate / 0 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -40 °C 1.2: 0 - 20 °C 2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 23 °C 3.1: pyridine / dichloromethane / 20 °C 4.1: hydrogen / N,N-dimethyl-formamide / 15 h / 20 °C / 2584.17 Torr 5.1: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 2 h / 20 °C 6.1: hydrogenchloride / methanol; water; 2-methyltetrahydrofuran / 0.5 h / 20 °C View Scheme |
4α-acetoxy-2α-benzoyIoxy-5β,20-epoxy-1β,13α-dihydroxy-10β-methoxy-9-oxo-7β-triethylsilyloxy-11-taxene
carbazitaxel
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C 2: potassium hydride / tetrahydrofuran / 0 - 20 °C 3: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran 4: water; hydrogenchloride / methanol / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 25 °C 2: sodium hydride / N,N-dimethyl acetamide / 1 h / -15 - -5 °C 3: dmap / tetrahydrofuran / 0.5 h / 20 - 30 °C 4: hydrogenchloride / ethyl acetate / 0 °C View Scheme | |
Multi-step reaction with 5 steps 1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 23 °C 2: pyridine / dichloromethane / 20 °C 3: hydrogen / N,N-dimethyl-formamide / 15 h / 20 °C / 2584.17 Torr 4: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 2 h / 20 °C 5: hydrogenchloride / methanol; water; 2-methyltetrahydrofuran / 0.5 h / 20 °C View Scheme |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-10β-methoxy-9-oxo-1β,13α,7β-trihydroxy-11-taxene
carbazitaxel
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium hydride / tetrahydrofuran / 0 - 20 °C 2: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran 3: water; hydrogenchloride / methanol / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydride / N,N-dimethyl acetamide / 1 h / -15 - -5 °C 2: dmap / tetrahydrofuran / 0.5 h / 20 - 30 °C 3: hydrogenchloride / ethyl acetate / 0 °C View Scheme | |
Multi-step reaction with 4 steps 1: pyridine / dichloromethane / 20 °C 2: hydrogen / N,N-dimethyl-formamide / 15 h / 20 °C / 2584.17 Torr 3: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 2 h / 20 °C 4: hydrogenchloride / methanol; water; 2-methyltetrahydrofuran / 0.5 h / 20 °C View Scheme |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
carbazitaxel
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran 2: water; hydrogenchloride / methanol / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: dmap / tetrahydrofuran / 0.5 h / 20 - 30 °C 2: hydrogenchloride / ethyl acetate / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 2 h / 20 °C 2: hydrogenchloride / methanol; water; 2-methyltetrahydrofuran / 0.5 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 5 h / 60 °C 2: formic acid / 4 h / 20 °C 3: methanol / 14 h / 25 - 35 °C View Scheme | |
Multi-step reaction with 2 steps 1: dicyclohexyl-carbodiimide; dmap / ethyl acetate / 3 h / 20 °C 2: hydrogenchloride / dichloromethane; methanol; water / 1 h / 0 °C View Scheme |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,10β-dihydroxy-9-oxo-7β,13α-di(triethylsilyloxy)-11-taxene
carbazitaxel
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: sodium hydride / tetrahydrofuran / -5 - 0 °C 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere 3: sodium hydride / tetrahydrofuran / -5 - 0 °C 4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere 5: dmap / tetrahydrofuran / 0.5 h / 20 - 30 °C 6: hydrogenchloride / ethyl acetate / 0 °C View Scheme | |
Multi-step reaction with 6 steps 1: sodium hydride / tetrahydrofuran / -5 - 0 °C 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere 3: sodium hydride / -5 - 0 °C 4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere 5: dmap; diisopropyl-carbodiimide / tetrahydrofuran / 20 - 30 °C 6: hydrogenchloride / ethyl acetate / 0 °C View Scheme |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β-hydroxy-9-oxo-10β-methoxy-7β,13α-di(triethylsilyloxy)-11-taxene
carbazitaxel
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere 2: sodium hydride / tetrahydrofuran / -5 - 0 °C 3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere 4: dmap / tetrahydrofuran / 0.5 h / 20 - 30 °C 5: hydrogenchloride / ethyl acetate / 0 °C View Scheme | |
Multi-step reaction with 5 steps 1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere 2: sodium hydride / -5 - 0 °C 3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere 4: dmap; diisopropyl-carbodiimide / tetrahydrofuran / 20 - 30 °C 5: hydrogenchloride / ethyl acetate / 0 °C View Scheme |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,7β-dihydroxy-9-oxo-10β-methoxy-13α-triethylsilyloxy-11-taxene
carbazitaxel
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium hydride / tetrahydrofuran / -5 - 0 °C 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere 3: dmap / tetrahydrofuran / 0.5 h / 20 - 30 °C 4: hydrogenchloride / ethyl acetate / 0 °C View Scheme | |
Multi-step reaction with 4 steps 1: sodium hydride / -5 - 0 °C 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere 3: dmap; diisopropyl-carbodiimide / tetrahydrofuran / 20 - 30 °C 4: hydrogenchloride / ethyl acetate / 0 °C View Scheme |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β-hydroxy-7β,10β-dimethoxy-9-oxo-13-(triethylsilyloxy)-11-taxene
carbazitaxel
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere 2: dmap / tetrahydrofuran / 0.5 h / 20 - 30 °C 3: hydrogenchloride / ethyl acetate / 0 °C View Scheme | |
Multi-step reaction with 3 steps 1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere 2: dmap; diisopropyl-carbodiimide / tetrahydrofuran / 20 - 30 °C 3: hydrogenchloride / ethyl acetate / 0 °C View Scheme |
2′-O-(tert-butyldimethylsilyl) cabazitaxel
carbazitaxel
Conditions | Yield |
---|---|
With pyridine; hydrogen fluoride In acetonitrile at -8 - 0℃; for 23.5h; | |
With pyridine; hydrogenchloride In acetonitrile at -8 - -3℃; for 1.5h; |
2’-(triethylsilyl)-7,10-(trichloroethoxycarbonyl)docetaxel
carbazitaxel
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: zinc; ammonium chloride / methanol; water / 4 h / 35 - 40 °C 2: n-butyllithium / tetrahydrofuran / 1 h / -10 - -5 °C 3: hydrogen fluoride; pyridine / acetonitrile / 23.5 h / -8 - 0 °C View Scheme | |
Multi-step reaction with 3 steps 1: zinc; ammonium chloride / methanol / 1 h / 20 °C 2: sodium hydride / 1 h / -10 - -5 °C 3: pyridine; hydrogen fluoride / acetonitrile / 23.5 h / -8 - 0 °C View Scheme |
4-nitrophenyl 2-(2-(pyridin-2-yl)disulfanyl)ethyl carbonate
carbazitaxel
Conditions | Yield |
---|---|
With dmap In dichloromethane at 20℃; | 99% |
With dmap In dichloromethane at 20℃; | 99% |
With dmap In dichloromethane at 20℃; | 99% |
carbazitaxel
N-Cbz-Ala
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-2-((((benzyloxy)carbonyl)-L-alanyl)oxy)-3-((tert-butoxycarbonyl)amino)-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; | 99% |
Conditions | Yield |
---|---|
With pyridine; dmap at 25℃; for 3h; | 98% |
With triethylamine In dichloromethane for 4h; | 87.3% |
With pyridine; potassium hydroxide at 30℃; Inert atmosphere; | 80% |
With dmap In dichloromethane at 20℃; | |
With dmap In dichloromethane at 20℃; |
Conditions | Yield |
---|---|
With dmap In dichloromethane at 25℃; Inert atmosphere; | 96% |
With dmap In dichloromethane; acetone at 22℃; Inert atmosphere; | 5.04 g |
carbazitaxel
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 25℃; Inert atmosphere; | 95% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 16h; Inert atmosphere; | 94% |
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 72h; | 93% |
carbazitaxel
6-(benzyloxycarbonylamino)hexanoic acid
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-2-((6-(((benzyloxy)carbonyl)amino)hexanoyl)oxy)-3-((tertbutoxycarbonyl)amino)-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; | 92% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at -5 - 2℃; for 33h; Product distribution / selectivity; | |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at -5 - 0℃; for 35h; |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 45℃; | 91.5% |
carbazitaxel
4-Nitrophenyl chloroformate
cabazitaxel-2’-p-nitrophenylcarbonate
Conditions | Yield |
---|---|
With pyridine In dichloromethane at -40℃; for 1h; | 91% |
With pyridine In dichloromethane at -40℃; for 2h; | 80% |
With pyridine In dichloromethane at -40℃; for 2h; | 80% |
With pyridine In dichloromethane at -40℃; for 2h; | 80% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃; for 5h; | 61.3% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃; | 91% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride |
carbazitaxel
N-(Benzyloxycarbonyl)glycine
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-2-((((benzyloxy)carbonyl)glycyl)oxy)-3-((tert-butoxycarbonyl)amino)-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; | 90% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at -5 - 2℃; for 33h; Product distribution / selectivity; | |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at -5 - 2℃; for 34h; | |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at -5 - -2℃; |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃; | 90% |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 1.5h; | 88.5% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃; | 87% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 45℃; | 83.6% |
Conditions | Yield |
---|---|
With triethylamine In chloroform at 20℃; | 83.5% |
4-(pyridin-2-yldisulfanyl) butyric acid
carbazitaxel
cabazitaxel butyrate pyridyldisulfide
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane; water; acetonitrile at 20℃; for 16h; | 83% |
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h; | 83% |
Conditions | Yield |
---|---|
With dichloro-acetic acid In dichloromethane at 20℃; for 4h; Inert atmosphere; | 79% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃; | 76% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride |
Conditions | Yield |
---|---|
With dichloro-acetic acid In dichloromethane at 20℃; for 4h; Inert atmosphere; | 73% |
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