Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:219861-08-2
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:219861-08-2
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryItems Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------
Cas:219861-08-2
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Trading Company
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White crystalline powder Storage:-20°C Freezer Package:1kg/fo
Cas:219861-08-2
Min.Order:1 Kilogram
FOB Price: $1000.0 / 1200.0
Type:Trading Company
inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
Cas:219861-08-2
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
Escitalopram oxalate English name: Escitalopram oxalate Chemical name: 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1, 3-dihydro-5-isobenzofuran-carbonitrile oxalate Category involved:
Cas:219861-08-2
Min.Order:1 Kilogram
FOB Price: $2.0 / 3.0
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:219861-08-2
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:219861-08-2
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
Cas:219861-08-2
Min.Order:1 Kilogram
FOB Price: $0.9 / 1.0
Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:219861-08-2
Min.Order:1 Kilogram
FOB Price: $9.0 / 99.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:219861-08-2
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ We can
Cas:219861-08-2
Min.Order:1 Kilogram
FOB Price: $15.0 / 20.0
Type:Trading Company
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv
Cas:219861-08-2
Min.Order:10 Gram
Negotiable
Type:Other
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:219861-08-2
Min.Order:1 Kilogram
FOB Price: $200.0 / 400.0
Type:Trading Company
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem (China) Co.,Ltd is Sp
Cas:219861-08-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:219861-08-2
Min.Order:10 Gram
FOB Price: $3.5
Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:219861-08-2
Min.Order:1 Gram
FOB Price: $86.0 / 100.0
Type:Trading Company
inquiryEscitalopram oxalate CAS:219861-08-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic int
Cas:219861-08-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:219861-08-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct Name: Escitalopram oxalate Synonyms: (S)-CITALOPRAM;1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran-carbonitrile oxalate;ESCITALOPRAM OXALATE;S-(+)-CITAPROLAM OXALATE;S-(+)-1-3-(dimethyl-amino)propyl-1-(p-fluoro
Cas:219861-08-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Cas:219861-08-2
Min.Order:1 Kilogram
FOB Price: $40.0 / 50.0
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Appearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:By Sea/Air/Courier Port:Qingdao
Cas:219861-08-2
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:219861-08-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:219861-08-2
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryHubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:219861-08-2
Min.Order:1 Kilogram
FOB Price: $3.0 / 5.0
Type:Trading Company
inquiryoxalic acid
(S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(hydroxymethyl)benzonitrile
escitalopram oxalate
Conditions | Yield |
---|---|
Stage #1: (S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(hydroxymethyl)benzonitrile With methanesulfonyl chloride; triethylamine In dichloromethane at 5℃; for 2h; Stage #2: oxalic acid | 65% |
Stage #1: (S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(hydroxymethyl)benzonitrile With potassium carbonate; 2,5-dichloronitrobenzene In dimethyl sulfoxide at 20 - 100℃; for 15h; Stage #2: oxalic acid In acetone at 30℃; | |
Stage #1: (S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(hydroxymethyl)benzonitrile With bis(phenyl) carbonate; sodium methylate In acetonitrile at 79 - 80℃; for 4h; Stage #2: oxalic acid In ethyl acetate for 3h; Reagent/catalyst; Reflux; | 3.02 g |
Conditions | Yield |
---|---|
Stage #1: (1S)-4-[4-(dimethylamino)-1-(4'-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile hemi-(+)-di-(p-toluoyl) tartaric acid salt With sodium hydroxide In diethyl ether; water at 25℃; for 0.5h; Stage #2: With triethylamine In diethyl ether; water; toluene at 5℃; for 0.5h; Stage #3: oxalic acid Further stages; | 85% |
Stage #1: (1S)-4-[4-(dimethylamino)-1-(4'-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile hemi-(+)-di-(p-toluoyl) tartaric acid salt With ammonia In dichloromethane; water pH=9; Stage #2: With triethylamine; p-toluenesulfonyl chloride In dichloromethane at 5℃; for 1h; Stage #3: oxalic acid In acetone | n/a |
Conditions | Yield |
---|---|
Stage #1: (S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(4-nitrobenzoyloxymethyl)benzonitrile hydrochloride With sodium hydrogencarbonate In water; ethyl acetate Stage #2: With potassium carbonate In dimethyl sulfoxide at 90 - 100℃; for 2h; Stage #3: oxalic acid | 82% |
Conditions | Yield |
---|---|
In acetone at 25 - 30℃; Industry scale; | 98.57% |
In acetonitrile at 50℃; for 0.5h; | 89% |
In acetone at 25 - 45℃; for 1.5h; | 85% |
(S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(2-nitro-4-chlorophenoxymethyl)benzonitrile hydrochloride
oxalic acid
escitalopram oxalate
Conditions | Yield |
---|---|
Stage #1: (S)-(-)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl]-3-(2-nitro-4-chlorophenoxymethyl)benzonitrile hydrochloride With potassium carbonate at 100℃; for 0.5h; Stage #2: oxalic acid | 64% |
Conditions | Yield |
---|---|
Stage #1: 1-(3-aminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile; (-)-di-p-toluoyl tartaric acid salt With sodium hydroxide In water; toluene pH=11 - 13; Stage #2: formaldehyd; formic acid In water at 95 - 100℃; for 3 - 4h; Stage #3: oxalic acid With hydrogenchloride more than 3 stages; |
Conditions | Yield |
---|---|
Stage #1: (S)-citalopram (L)-tartrate With sodium hydroxide In water; ethyl acetate pH=10; Stage #2: oxalic acid In ethyl acetate |
escitalopram
escitalopram oxalate
Conditions | Yield |
---|---|
With oxalic acid In acetone at 10℃; for 1h; | |
With oxalic acid In ethanol at 5 - 20℃; for 10.5h; Product distribution / selectivity; |
oxalic acid
escitalopram oxalate
Conditions | Yield |
---|---|
Stage #1: escitalopram With hydrogen bromide In isopropyl alcohol at 20℃; for 2.16667h; pH=3.5 - 4; Stage #2: With ammonia In water; ethyl acetate for 0.5h; pH=9 - 9.5; Stage #3: oxalic acid In isopropyl alcohol at 20 - 40℃; for 2.16667h; Purification / work up; | |
Stage #1: oxalic acid With ammonia In water; ethyl acetate pH=9 - 9.5; Stage #2: oxalic acid In isopropyl alcohol at 20 - 40℃; for 2.16667h; Purification / work up; | |
Stage #1: (+)-(S)-citalopram hydrobromide With ammonia In water; ethyl acetate pH=9 - 9.5; Stage #2: oxalic acid In isopropyl alcohol at 20 - 40℃; for 2.16667h; Purification / work up; |
4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile
escitalopram oxalate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: isopropyl alcohol / 3 h / 20 - 45 °C 2.1: ammonia / water / pH ~ 9 2.2: 3 h / -5 °C 3.1: isopropyl alcohol / 0.5 h / 50 - 60 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: isopropyl alcohol / 25 - 70 °C / Resolution of racemate 2.1: ammonium hydroxide / dichloromethane; water / 1 h / 5 - 15 °C 2.2: -5 - 5 °C 3.1: acetone / 20 - 40 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: isopropyl alcohol / 25 - 35 °C 2.1: sodium hydroxide / diethyl ether; water / 0.5 h / 25 °C 3.1: triethylamine / toluene / 0.5 h / 5 °C 3.2: 1 h / 5 °C 4.1: acetone / 1.5 h / 25 - 45 °C View Scheme |
Conditions | Yield |
---|---|
With stainless steel column (100 mm L x 4.6 mm i.d) packed with iniferter-mediated grafting of molecularly imprinted polymers on porous silica beads In acetonitrile at 40℃; pH=3; Resolution of racemate; |
4-flourophenylmagnesium bromide
escitalopram oxalate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: tetrahydrofuran / 0.25 h / -5 °C 1.2: 0.5 h / -5 - 20 °C 1.3: pH 2 2.1: isopropyl alcohol / 3 h / 20 - 45 °C 3.1: ammonia / water / pH ~ 9 3.2: 3 h / -5 °C 4.1: isopropyl alcohol / 0.5 h / 50 - 60 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: tetrahydrofuran / 4 h / 5 - 15 °C / Inert atmosphere 1.2: 4 h / 0 - 15 °C 2.1: hydrogen bromide / 1.5 h / 5 - 30 °C 3.1: sodium hydroxide / water / 0.5 h / 25 °C 3.2: 4 h / 25 - 40 °C 4.1: sodium hydroxide / water; toluene / 0.5 h / 25 °C 4.2: 0.25 h / 25 °C 4.3: 1 h / -15 °C 5.1: acetonitrile / 4.5 h / 25 - 50 °C View Scheme |
3-(N,N-dimethylamino)propylmagnesium chloride
escitalopram oxalate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: tetrahydrofuran / 0.25 h / -5 °C 1.2: 0.5 h / -5 - 20 °C 1.3: pH 2 2.1: isopropyl alcohol / 3 h / 20 - 45 °C 3.1: ammonia / water / pH ~ 9 3.2: 3 h / -5 °C 4.1: isopropyl alcohol / 0.5 h / 50 - 60 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: tetrahydrofuran / 4 h / 5 - 15 °C / Inert atmosphere 1.2: 4 h / 0 - 15 °C 2.1: hydrogen bromide / 1.5 h / 5 - 30 °C 3.1: sodium hydroxide / water / 0.5 h / 25 °C 3.2: 4 h / 25 - 40 °C 4.1: sodium hydroxide / water; toluene / 0.5 h / 25 °C 4.2: 0.25 h / 25 °C 4.3: 1 h / -15 °C 5.1: acetonitrile / 4.5 h / 25 - 50 °C View Scheme |
1-Bromo-4-fluorobenzene
escitalopram oxalate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: iodine; magnesium / tetrahydrofuran / 5 h / 80 - 85 °C / Reflux 2.1: tetrahydrofuran / 0.25 h / -5 °C 2.2: 0.5 h / -5 - 20 °C 2.3: pH 2 3.1: isopropyl alcohol / 3 h / 20 - 45 °C 4.1: ammonia / water / pH ~ 9 4.2: 3 h / -5 °C 5.1: isopropyl alcohol / 0.5 h / 50 - 60 °C View Scheme |
3-(dimethylamino)propyl chloride hydrochloride
escitalopram oxalate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: potassium hydroxide / water / 0 - 5 °C 1.2: 4 h / 100 - 110 °C / Reflux 2.1: tetrahydrofuran / 0.25 h / -5 °C 2.2: 0.5 h / -5 - 20 °C 2.3: pH 2 3.1: isopropyl alcohol / 3 h / 20 - 45 °C 4.1: ammonia / water / pH ~ 9 4.2: 3 h / -5 °C 5.1: isopropyl alcohol / 0.5 h / 50 - 60 °C View Scheme |
(R)-4-(4-dimethylamino-1-(4'-fluorophenyl)-1-hydroxybutyl)-3-hydroxymethylbenzonitrile, salt with (+)-O,O'-di-p-toluoyltartaric acid
escitalopram oxalate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: ammonia / water / pH ~ 9 1.2: 3 h / -5 °C 2.1: isopropyl alcohol / 0.5 h / 50 - 60 °C View Scheme |
escitalopram oxalate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: ammonium hydroxide / dichloromethane; water / 1 h / 5 - 15 °C 1.2: -5 - 5 °C 2.1: acetone / 20 - 40 °C View Scheme |
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile
escitalopram oxalate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: tetrahydrofuran / 4 h / 5 - 15 °C / Inert atmosphere 1.2: 4 h / 0 - 15 °C 2.1: hydrogen bromide / 1.5 h / 5 - 30 °C 3.1: sodium hydroxide / water / 0.5 h / 25 °C 3.2: 4 h / 25 - 40 °C 4.1: sodium hydroxide / water; toluene / 0.5 h / 25 °C 4.2: 0.25 h / 25 °C 4.3: 1 h / -15 °C 5.1: acetonitrile / 4.5 h / 25 - 50 °C View Scheme |
4-(4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile hydrobromide
escitalopram oxalate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydroxide / water / 0.5 h / 25 °C 1.2: 4 h / 25 - 40 °C 2.1: sodium hydroxide / water; toluene / 0.5 h / 25 °C 2.2: 0.25 h / 25 °C 2.3: 1 h / -15 °C 3.1: acetonitrile / 4.5 h / 25 - 50 °C View Scheme |
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