Cas no. 184475-71-6 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol Gefinitinib Intermediates Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below:
Cas:184475-71-6
Min.Order:100 Gram
Negotiable
Type:Trading Company
inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s
Cas:184475-71-6
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:184475-71-6
Min.Order:0 Metric Ton
Negotiable
Type:Manufacturers
inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
Cas:184475-71-6
Min.Order:1 Kilogram
FOB Price: $0.9 / 1.0
Type:Lab/Research institutions
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:184475-71-6
Min.Order:1
Negotiable
Type:Other
inquiryHigh quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr
Cas:184475-71-6
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:184475-71-6
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/571.html Product Name 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol
Cas:184475-71-6
Min.Order:1 Gram
FOB Price: $53.0
Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:184475-71-6
Min.Order:1 Kilogram
FOB Price: $9.0 / 99.0
Type:Trading Company
inquiryHenan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com
Cas:184475-71-6
Min.Order:1 Gram
FOB Price: $1000.0
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:184475-71-6
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;
Cas:184475-71-6
Min.Order:0 Metric Ton
Negotiable
Type:Trading Company
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:184475-71-6
Min.Order:10 Gram
Negotiable
Type:Other
inquiryProduct: Gefitinib Intermediate Chemical name:4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ol Batch NO: 20210405 Analysis Date: 2021-04-25 Expiry Date: 2023-04-24 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integ
Cas:184475-71-6
Min.Order:1 Kilogram
FOB Price: $480.0 / 500.0
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:184475-71-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:184475-71-6
Min.Order:1 Kilogram
FOB Price: $51.0 / 58.0
Type:Trading Company
inquiry4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol CAS:184475-71-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, sp
Cas:184475-71-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:184475-71-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry4-(3-chloro-4-fluorophenylami-no)-7-methoxyquinazolin-6-ol(CAS:184475-71-6) is an important pharmaceutical intermediate of Gefitinib and one of the most competitive products in our company. Please feel free to contact us for more details. Appearance:
Cas:184475-71-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Cas:184475-71-6
Min.Order:0
Negotiable
Type:Manufacturers
inquiryOur Service 1.Own made fine chemical products 2.Out sourcing and quality controlling service in China 3. COM for Chemical synthesis 4.Lab custom synthesis of API and intermadiates Quality Assurance 1. NMR,HPLC and COA can be supplied 2. Free
Cas:184475-71-6
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s
Cas:184475-71-6
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:184475-71-6
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:184475-71-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:184475-71-6
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryChemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Cas:184475-71-6
Min.Order:100 Gram
Negotiable
Type:Other
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:184475-71-6
Min.Order:10 Gram
FOB Price: $10.0 / 100.0
Type:Lab/Research institutions
inquiryProduct name: 4-(3-Chloro-4-Fluorophenylamino)-7-Methoxyquinazolin-6-ol CAS No.: 184475-71-6 Molecule Formula:C15H11ClFN3O2 Molecule Weight:319.72 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Stand
Cas:184475-71-6
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryHuarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.
Cas:184475-71-6
Min.Order:1 Gram
FOB Price: $1.0 / 2.0
Type:Trading Company
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:184475-71-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
With ammonium hydroxide In methanol at 20℃; for 13h; Inert atmosphere; | 99% |
With sodium methylate In methanol for 3h; Reflux; | 95.3% |
With methanol; ammonium hydroxide at 20℃; for 3h; | 95% |
3-chloro-4-fluorophenylamine
N,N-dimethyl-formamide dimethyl acetal
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
With acetic acid In toluene at 65℃; for 7h; Solvent; Temperature; Concentration; Reagent/catalyst; Inert atmosphere; | 97% |
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Stage #1: 4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl acetate hydrochloride With lithium hydroxide; water In methanol at 20℃; for 0.5h; Stage #2: With acetic acid In methanol; water | 94% |
With lithium hydroxide; water In methanol at 20℃; for 0.5h; | 94% |
Stage #1: 4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl acetate hydrochloride With methanol; lithium hydroxide; water at 20℃; for 0.5h; Stage #2: With acetic acid In water | 94% |
6-(benzyloxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
With methanesulfonic acid In chloroform for 5h; Reflux; | 91% |
With trifluoroacetic acid at 75℃; for 4h; | 90% |
With palladium 10% on activated carbon; hydrogen In methanol under 3102.97 Torr; for 24h; | 82% |
N,N'-bis(3-chloro-4-fluorophenyl)formamidine
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene at 110℃; for 5h; | 84.2% |
3-chloro-4-fluorophenylamine
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Stage #1: 4-chloro-7-methoxyquinazolin-6-yl acetate hydrochloride salt; 3-chloro-4-fluorophenylamine In N,N-dimethyl-formamide at 80℃; for 1h; Stage #2: With ammonia; water In methanol for 2h; Reflux; | 75% |
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane at 20℃; not specified; | 44% |
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: propan-2-ol / 5 h / 90 °C 2: 90 percent / ammonia / methanol; H2O / 24 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: toluene; isopropyl alcohol / 3 h / 20 - 65 °C 2: lithium hydroxide / water; methanol / 1 h / 20 °C View Scheme |
6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 92 percent / N,N-diethylaniline; phosphoryl chloride / 1 h / 80 - 100 °C 2: propan-2-ol / 5 h / 90 °C 3: 90 percent / ammonia / methanol; H2O / 24 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: SOCl2 2: NH4OH / methanol View Scheme | |
Multi-step reaction with 3 steps 1: trichlorophosphate / toluene / Reflux 2: pyridine / isopropyl alcohol / Reflux 3: water; sodium hydroxide / methanol View Scheme |
3H-6,7-dimethoxyquinazolin-4-one
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: L-methionine; methanesulfonic acid / 12 h / Heating 2: pyridine; 4-(dimethylamino)pyridine / 6 h / 100 °C 3: 92 percent / N,N-diethylaniline; phosphoryl chloride / 1 h / 80 - 100 °C 4: propan-2-ol / 5 h / 90 °C 5: 90 percent / ammonia / methanol; H2O / 24 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1: methionine; MeSO3H / 3 h / 100 °C 2: pyridine 3: SOCl2 4: NH4OH / methanol View Scheme | |
Multi-step reaction with 5 steps 1: methanesulfonic acid; L-methionine / 120 °C 2: pyridine; dmap / 100 °C 3: trichlorophosphate / toluene / Reflux 4: pyridine / isopropyl alcohol / Reflux 5: water; sodium hydroxide / methanol View Scheme |
6-hydroxy-7-methoxyquinazolin-4(3H)-one
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: pyridine; 4-(dimethylamino)pyridine / 6 h / 100 °C 2: 92 percent / N,N-diethylaniline; phosphoryl chloride / 1 h / 80 - 100 °C 3: propan-2-ol / 5 h / 90 °C 4: 90 percent / ammonia / methanol; H2O / 24 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: pyridine 2: SOCl2 3: NH4OH / methanol View Scheme | |
Multi-step reaction with 4 steps 1: pyridine; dmap / 100 °C 2: trichlorophosphate / toluene / Reflux 3: pyridine / isopropyl alcohol / Reflux 4: water; sodium hydroxide / methanol View Scheme |
6-acetoxy-4-chloro-7-methoxyquinazoline
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NH4OH / methanol View Scheme | |
Multi-step reaction with 2 steps 1: pyridine / isopropyl alcohol / Reflux 2: water; sodium hydroxide / methanol View Scheme | |
Multi-step reaction with 2 steps 1: isopropyl alcohol / 5 h / 88 °C 2: water; sodium hydroxide / methanol / 6 h / 20 °C View Scheme |
2-carboethoxy-4,5-dimethoxyaniline
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 160 - 170 °C 2: methanesulfonic acid; L-methionine / 120 °C 3: pyridine; dmap / 100 °C 4: trichlorophosphate / toluene / Reflux 5: pyridine / isopropyl alcohol / Reflux 6: water; sodium hydroxide / methanol View Scheme | |
Multi-step reaction with 6 steps 1: 165 - 170 °C 2: L-methionine; methanesulfonic acid 3: pyridine / 100 °C 4: thionyl chloride; N,N-dimethyl-formamide / 90 °C 5: isopropyl alcohol / Reflux 6: ammonia / water; methanol / 24 h / 20 °C View Scheme |
ethyl 2-nitro-4,5-dimethoxybenzoate
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: palladium on activated charcoal; hydrogen 2: 160 - 170 °C 3: methanesulfonic acid; L-methionine / 120 °C 4: pyridine; dmap / 100 °C 5: trichlorophosphate / toluene / Reflux 6: pyridine / isopropyl alcohol / Reflux 7: water; sodium hydroxide / methanol View Scheme | |
Multi-step reaction with 7 steps 1: iron; hydrogenchloride / ethanol; water / Reflux 2: 165 - 170 °C 3: L-methionine; methanesulfonic acid 4: pyridine / 100 °C 5: thionyl chloride; N,N-dimethyl-formamide / 90 °C 6: isopropyl alcohol / Reflux 7: ammonia / water; methanol / 24 h / 20 °C View Scheme |
ethyl veratrate
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: nitric acid; acetic acid / 0 - 5 °C 2: palladium on activated charcoal; hydrogen 3: 160 - 170 °C 4: methanesulfonic acid; L-methionine / 120 °C 5: pyridine; dmap / 100 °C 6: trichlorophosphate / toluene / Reflux 7: pyridine / isopropyl alcohol / Reflux 8: water; sodium hydroxide / methanol View Scheme | |
Multi-step reaction with 8 steps 1: nitric acid / 0 °C 2: iron; hydrogenchloride / ethanol; water / Reflux 3: 165 - 170 °C 4: L-methionine; methanesulfonic acid 5: pyridine / 100 °C 6: thionyl chloride; N,N-dimethyl-formamide / 90 °C 7: isopropyl alcohol / Reflux 8: ammonia / water; methanol / 24 h / 20 °C View Scheme |
Veratric acid
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: sulfuric acid / Reflux 2: nitric acid; acetic acid / 0 - 5 °C 3: palladium on activated charcoal; hydrogen 4: 160 - 170 °C 5: methanesulfonic acid; L-methionine / 120 °C 6: pyridine; dmap / 100 °C 7: trichlorophosphate / toluene / Reflux 8: pyridine / isopropyl alcohol / Reflux 9: water; sodium hydroxide / methanol View Scheme | |
Multi-step reaction with 9 steps 1: sulfuric acid 2: nitric acid / 0 °C 3: iron; hydrogenchloride / ethanol; water / Reflux 4: 165 - 170 °C 5: L-methionine; methanesulfonic acid 6: pyridine / 100 °C 7: thionyl chloride; N,N-dimethyl-formamide / 90 °C 8: isopropyl alcohol / Reflux 9: ammonia / water; methanol / 24 h / 20 °C View Scheme |
2-Amino-4,5-dimethoxybenzoic acid
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: trimethyl orthoformate / methanol / 4 h / 70 °C / Reflux 2.1: methanesulfonic acid; DL-methionine / 3 h / 130 °C / Cooling with ice 2.2: pH 7 3.1: pyridine / 3 h / 20 - 100 °C 4.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 70 °C 5.1: isopropyl alcohol / 5 h / 88 °C 6.1: water; sodium hydroxide / methanol / 6 h / 20 °C View Scheme | |
Multi-step reaction with 6 steps 1: trimethyl orthoformate / methanol / 4 h / 70 °C 2: DL-methionine; methanesulfonic acid / 3 h / 130 °C 3: pyridine / 3 h / 100 °C 4: thionyl chloride / N,N-dimethyl-formamide / 3 h / 70 °C 5: isopropyl alcohol / 5 h / 88 °C 6: sodium hydroxide; methanol / 6 h / 20 °C View Scheme | |
Multi-step reaction with 6 steps 1: water / Microwave irradiation 2: magnesium sulfate; methanesulfonic acid 3: pyridine / 20 °C 4: triethylamine; trichlorophosphate / acetonitrile / 80 °C 5: 1,4-dioxane 6: sodium hydroxide / water; tetrahydrofuran / 4 h / 20 °C View Scheme |
methyl 2-amino-4,5-dimethoxybenzoate
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: formamide / 2 h / 190 - 200 °C 2: methanesulfonic acid; L-methionine / 5 h / 150 - 160 °C 3: pyridine / 3 h / Heating / reflux 4: trichlorophosphate / 3 h / Heating / reflux 5: isopropyl alcohol / 3 h / Heating / reflux 6: methanol; lithium hydroxide; water / 0.5 h / 20 °C View Scheme | |
Multi-step reaction with 6 steps 1: methanol; N,N-dimethyl-formamide / Inert atmosphere 2: methanesulfonic acid; DL-methionine / Inert atmosphere 3: pyridine / Inert atmosphere 4: thionyl chloride / N,N-dimethyl-formamide / Inert atmosphere 5: isopropyl alcohol / Inert atmosphere 6: ammonium hydroxide / 3 h / Inert atmosphere; Reflux View Scheme |
3-chloro-4-fluorophenylamine
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: triethylamine; trichlorophosphate / toluene / 20 - 60 °C 1.2: 2 h / 65 °C 2.1: lithium hydroxide; water / methanol / 0.5 h / 20 °C View Scheme |
6-(benzyloxy)-4-chloro-7-methoxyquinazoline
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 60 - 65 °C 2: methanesulfonic acid / chloroform / 5 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: isopropyl alcohol / Reflux 2: trifluoroacetic acid / 1 h / Reflux View Scheme |
isovanillin
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: aminosulfonic acid; sodium chlorite / water / 2 h / 5 - 8 °C 2.1: hydrogenchloride / 4 h / 50 - 55 °C 3.1: potassium carbonate; potassium iodide / acetone / 25 - 30 °C 3.2: Reflux 4.1: nitric acid; acetic acid / 14 h / 25 - 35 °C 5.1: acetic acid; iron / 50 - 60 °C 6.1: ethyl acetate / 12 h / Reflux 7.1: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / chloroform / 12 h / 60 - 65 °C 8.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 60 - 65 °C 9.1: methanesulfonic acid / chloroform / 5 h / Reflux View Scheme | |
Multi-step reaction with 7 steps 1: sodium formate; formic acid; hydroxyammonium sulfate / 85 °C 2: potassium carbonate / acetonitrile / 1.5 h / Reflux 3: acetic acid; nitric acid / 1 h / Cooling with ice 4: tin(ll) chloride; hydrogenchloride / water; acetic acid / 1 h / 60 °C 5: acetic acid / benzene / 2 h / 105 °C / Dean-Stark 6: acetic acid / 3 h / 130 - 140 °C 7: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 3102.97 Torr View Scheme |
Isovanillic acid
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: hydrogenchloride / 4 h / 50 - 55 °C 2.1: potassium carbonate; potassium iodide / acetone / 25 - 30 °C 2.2: Reflux 3.1: nitric acid; acetic acid / 14 h / 25 - 35 °C 4.1: acetic acid; iron / 50 - 60 °C 5.1: ethyl acetate / 12 h / Reflux 6.1: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / chloroform / 12 h / 60 - 65 °C 7.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 60 - 65 °C 8.1: methanesulfonic acid / chloroform / 5 h / Reflux View Scheme | |
Multi-step reaction with 8 steps 1: sulfuric acid / methanol / Reflux 2: potassium carbonate / butanone / Reflux 3: nitric acid; acetic acid / 30 °C 4: iron; ammonium chloride / methanol; water / Reflux 5: acetic acid; formamide / Reflux 6: trichlorophosphate; N,N-dimethyl-formamide / Reflux 7: isopropyl alcohol / Reflux 8: trifluoroacetic acid / 1 h / Reflux View Scheme |
3-hydroxy-4-methoxybenzoate
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: potassium carbonate; potassium iodide / acetone / 25 - 30 °C 1.2: Reflux 2.1: nitric acid; acetic acid / 14 h / 25 - 35 °C 3.1: acetic acid; iron / 50 - 60 °C 4.1: ethyl acetate / 12 h / Reflux 5.1: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / chloroform / 12 h / 60 - 65 °C 6.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 60 - 65 °C 7.1: methanesulfonic acid / chloroform / 5 h / Reflux View Scheme | |
Multi-step reaction with 7 steps 1: potassium carbonate / butanone / Reflux 2: nitric acid; acetic acid / 30 °C 3: iron; ammonium chloride / methanol; water / Reflux 4: acetic acid; formamide / Reflux 5: trichlorophosphate; N,N-dimethyl-formamide / Reflux 6: isopropyl alcohol / Reflux 7: trifluoroacetic acid / 1 h / Reflux View Scheme |
methyl 3-(benzyloxy)-4-methoxy-benzoate
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: nitric acid; acetic acid / 14 h / 25 - 35 °C 2: acetic acid; iron / 50 - 60 °C 3: ethyl acetate / 12 h / Reflux 4: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / chloroform / 12 h / 60 - 65 °C 5: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 60 - 65 °C 6: methanesulfonic acid / chloroform / 5 h / Reflux View Scheme | |
Multi-step reaction with 6 steps 1: nitric acid; acetic acid / 30 °C 2: iron; ammonium chloride / methanol; water / Reflux 3: acetic acid; formamide / Reflux 4: trichlorophosphate; N,N-dimethyl-formamide / Reflux 5: isopropyl alcohol / Reflux 6: trifluoroacetic acid / 1 h / Reflux View Scheme |
methyl 5-(benzyloxy)-4-methoxy-2-nitrobenzoate
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: acetic acid; iron / 50 - 60 °C 2: ethyl acetate / 12 h / Reflux 3: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / chloroform / 12 h / 60 - 65 °C 4: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 60 - 65 °C 5: methanesulfonic acid / chloroform / 5 h / Reflux View Scheme | |
Multi-step reaction with 5 steps 1: iron; ammonium chloride / methanol; water / Reflux 2: acetic acid; formamide / Reflux 3: trichlorophosphate; N,N-dimethyl-formamide / Reflux 4: isopropyl alcohol / Reflux 5: trifluoroacetic acid / 1 h / Reflux View Scheme |
methyl 2-amino-5-(benzyloxy)-4-methoxybenzoate
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: ethyl acetate / 12 h / Reflux 2: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / chloroform / 12 h / 60 - 65 °C 3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 60 - 65 °C 4: methanesulfonic acid / chloroform / 5 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1: acetic acid; formamide / Reflux 2: trichlorophosphate; N,N-dimethyl-formamide / Reflux 3: isopropyl alcohol / Reflux 4: trifluoroacetic acid / 1 h / Reflux View Scheme |
6-(benzyloxy)-7-methoxyquinazolin-4(3H)-one
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / chloroform / 12 h / 60 - 65 °C 2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 60 - 65 °C 3: methanesulfonic acid / chloroform / 5 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: trichlorophosphate; N,N-dimethyl-formamide / Reflux 2: isopropyl alcohol / Reflux 3: trifluoroacetic acid / 1 h / Reflux View Scheme |
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acetic acid / 3 h / 130 - 140 °C 2: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 3102.97 Torr View Scheme |
2-methoxy-5-cyanophenol
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: potassium carbonate / acetonitrile / 1.5 h / Reflux 2: acetic acid; nitric acid / 1 h / Cooling with ice 3: tin(ll) chloride; hydrogenchloride / water; acetic acid / 1 h / 60 °C 4: acetic acid / benzene / 2 h / 105 °C / Dean-Stark 5: acetic acid / 3 h / 130 - 140 °C 6: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 3102.97 Torr View Scheme | |
Multi-step reaction with 4 steps 1: potassium carbonate / methanol / 1 h / 65 °C / Inert atmosphere 2: nitric acid; acetic acid / 0 - 25 °C / Inert atmosphere 3: palladium 10% on activated carbon; hydrogen / methanol / 1.5 h / 20 °C / 1520.1 - 2280.15 Torr 4: acetic acid / toluene / 7 h / 65 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1: potassium carbonate / methanol / 1 h / 65 °C / Inert atmosphere 2: nitric acid; acetic acid / 0 - 25 °C / Inert atmosphere 3: tetrabutylammomium bromide; sodium dithionite; water / methanol / 30 °C / Inert atmosphere 4: acetic acid / 110 °C / Inert atmosphere 5: trifluoroacetic acid / 4 h / 75 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium carbonate / acetonitrile / 0.17 h / 20 °C 1.2: 5 h / Reflux 2.1: acetic acid; nitric acid / 1 h / Cooling with ice 3.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2327.23 Torr 4.1: toluene-4-sulfonic acid / toluene / 5 h / 110 °C View Scheme |
propargyl bromide
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
4-(3'-chloro-4'-fluoroanilino)-6-(prop-2-ynyloxy)-7-methoxyquinazoline
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12h; Inert atmosphere; | 99% |
tert-butyl 3-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]propanoate
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 1h; | 98.5% |
(E)-methyl 3-(4-(2-(tosyloxy)ethoxy)phenyl)acrylate
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
(E)-methyl 3-(4-(2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)ethoxy)phenyl) acrylate
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 24h; | 98% |
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 24h; | 98% |
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 24h; | 98% |
trifluoroacetic acid
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
tert-butyl 4-(3-bromopropyl)-piperazine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: 4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline; tert-butyl 4-(3-bromopropyl)-piperazine-1-carboxylate With potassium carbonate In N,N-dimethyl-formamide at 80℃; Stage #2: trifluoroacetic acid In methanol; water | 97% |
trifluoromethylsulfonic anhydride
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
4-(3'-chloro-4'-fluorophenylamino)-7-methoxy-6-(trifluoromethanesulfonyloxy)quinazoline
Conditions | Yield |
---|---|
With pyridine at 0 - 20℃; Inert atmosphere; | 94% |
With pyridine at -6 - 20℃; | 62% |
N-phthaloylglycine chloride
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
With dmap In dichloromethane at 20℃; for 4.5h; Inert atmosphere; Cooling with ice; | 93.2% |
1-bromo-6-hexanol
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
6-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)hexan-1-ol
Conditions | Yield |
---|---|
Stage #1: 4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline With potassium carbonate In N,N-dimethyl-formamide at 40℃; for 0.166667h; Stage #2: 1-bromo-6-hexanol In N,N-dimethyl-formamide at 60℃; for 6h; | 93% |
methanesulfonic acid 2-[2-(2-{2-[3-(2,2,2-trifluoro-1,1-bis-trifluoromethyl-ethoxy)-2,2-bis-(2,2,2-trifluoro-1,1-bis-trifluoromethyl-ethoxymethyl)-propoxy]-ethoxy}-ethoxy)-ethoxy]-ethyl ester
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 12h; | 93% |
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 130℃; for 6h; | 92.8% |
With potassium carbonate In N,N-dimethyl-formamide at 130℃; for 6h; | 66% |
4-(3-chloropropyl)morpholine
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
gefitinib
Conditions | Yield |
---|---|
With 18-crown-6 ether; potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 60℃; for 3h; Reagent/catalyst; Temperature; | 92% |
With tetrabutylammomium bromide; sodium carbonate; potassium iodide In iso-butanol Reflux; | 90% |
In N,N-dimethyl-formamide at 80 - 90℃; Concentration; | 88% |
1-chloro-3-hydroxypropane
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
M 527301
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In acetonitrile for 12h; Reflux; | 91% |
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 130℃; for 6h; | 89.8% |
With potassium carbonate In N,N-dimethyl-formamide at 130℃; for 6h; | 66% |
3-morpholinopropyl 4-methylbenzenesulfonate
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
gefitinib
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide at 80℃; for 6h; Solvent; Temperature; | 89.5% |
methanesulfonic acid 3-morpholin-4-yl-propyl ester
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
gefitinib
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide at 80℃; for 6h; Solvent; Temperature; | 89.2% |
1,3-chlorobromopropane
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
6-(3-chloropropoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-ylamine
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 40℃; for 6h; | 89% |
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 40℃; for 6h; | 89% |
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 4h; | |
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 4h; Heating; | Ca. 330 mg |
ethyl 5-bromovalerate
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 40℃; for 0.5h; | 88% |
4-(3-chloropropyl)morpholine
ethylene glycol
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 70 - 80℃; for 8h; | 85.9% |
allyl bromide
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 90℃; for 4h; | 82% |
4-bromoethylbutanoate
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
ethyl 4-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)butanoate
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 40℃; for 0.5h; | 81% |
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 80℃; Inert atmosphere; | 80% |
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
6-(3-(4-benzylhexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl)propoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine
Conditions | Yield |
---|---|
With tetra-(n-butyl)ammonium iodide; potassium carbonate In N,N-dimethyl-formamide at 90℃; for 18h; | 79.59% |
With tetra-(n-butyl)ammonium iodide; potassium carbonate In N,N-dimethyl-formamide at 90℃; for 18h; | 79.59% |
2-bromoethyl 2,3,4-tri-O-acetyl-β-D-xylopyranoside
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
Conditions | Yield |
---|---|
Stage #1: 4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.333333h; Stage #2: 2-bromoethyl 2,3,4-tri-O-acetyl-β-D-xylopyranoside In N,N-dimethyl-formamide at 80℃; for 8h; Inert atmosphere; | 79% |
4 (3-bromopropyl)-morpholine
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
gefitinib
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 12h; | 78% |
2-(3-chloropropyl)octahydrocyclopenta[c]pyrrole
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)propoxy)-7-methoxyquinazolin-4-amine
Conditions | Yield |
---|---|
With tetra-(n-butyl)ammonium iodide; potassium carbonate In N,N-dimethyl-formamide at 90℃; for 12h; | 75.59% |
With tetra-(n-butyl)ammonium iodide; potassium carbonate In N,N-dimethyl-formamide at 90℃; for 12h; Inert atmosphere; |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View