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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% LONAFARNIB 193275-84-2 GMP Manufacturer

Cas:193275-84-2

Min.Order:1 Gram

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 193275-84-2 with best quality

Cas:193275-84-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

LONAFARNIB CAS:193275-84-2

Cas:193275-84-2

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

Supply High Quality Lonafarnib CAS 193275-84-2 For research Use only

Cas:193275-84-2

Min.Order:1 Gram

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Qingdao Beluga Import and Export Co., LTD

LONAFARNIB CAS:193275-84-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

LONAFARNIB CAS:193275-84-2

Cas:193275-84-2

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

SCH66336 Lonafarnib 193275-84-2

Cas:193275-84-2

Min.Order:200 Milligram

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Lonafarnib

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceuti

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Lonafarnib

Cas:193275-84-2

Min.Order:1 Milligram

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Hebei Mojin Biotechnology Co.,Ltd

1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

LONAFARNIB

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Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

LONAFARNIB

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Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

LONAFARNIB

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Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

LONAFARNIB

Cas:193275-84-2

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice.pls contact with us freely for getting detailed product spec

LONAFARNIB

Cas:193275-84-2

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

BOC Sciences

GMP factory Packing with pallet as buyer's special request Best service after shipment with e-mail Cargos together with container sales seervice available Api, inhibitor, and fine chemicals for more

Lonafarnib cas 193275-84-2

Cas:193275-84-2

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Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

LONAFARNIB CAS No.193275-84-2

Cas:193275-84-2

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DB BIOTECH CO., LTD

best seller Application:API

LONAFARNIB

Cas:193275-84-2

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Hangzhou Fandachem Co.,Ltd

1-Piperidinecarboxamide,4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Ap

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

LONAFARNIB

Cas:193275-84-2

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Shanghai Yuanye Bio-Technology Co., Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:5mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any port

Lonafarnib

Cas:193275-84-2

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Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

LONAFARNIB

Cas:193275-84-2

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Hebei Muhuang Technology Co., Ltd

best seller Application:API

LONAFARNIB

Cas:193275-84-2

Min.Order:0

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Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

Lonafarnib

Cas:193275-84-2

Min.Order:0

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Synthetic route

VI, N-α-t-boc L-asparagin

VI, N-α-t-boc L-asparagin

sodium isocyanate
917-61-3

sodium isocyanate

lonafarnib
193275-84-2

lonafarnib

Conditions
ConditionsYield
With sodium carbonate In tetrahydrofuran; water at 20 - 50℃; for 4h;95%
trimethylsilyl isocyanate
1118-02-1

trimethylsilyl isocyanate

(+)-4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11(R)-yl)-1-<(4-piperidinyl)acetyl>piperidine
193276-77-6

(+)-4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11(R)-yl)-1-<(4-piperidinyl)acetyl>piperidine

lonafarnib
193275-84-2

lonafarnib

Conditions
ConditionsYield
In dichloromethane at 25℃; for 48h;82%
urea
57-13-6

urea

(+)-4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11(R)-yl)-1-<(4-piperidinyl)acetyl>piperidine
193276-77-6

(+)-4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11(R)-yl)-1-<(4-piperidinyl)acetyl>piperidine

lonafarnib
193275-84-2

lonafarnib

Conditions
ConditionsYield
With sodium hydroxide In 1-methyl-pyrrolidin-2-one; ethanol at 110℃; for 10h; pH=9;5.44 g
2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid
157688-46-5

2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid

lonafarnib
193275-84-2

lonafarnib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 80 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide; toluene / 18 h / 20 °C
2: hydrochloric acid / ethanol / 6 h / 20 °C
3: 5.44 g / NaOH / ethanol; 1-methyl-pyrrolidin-2-one / 10 h / 110 °C / pH 9
View Scheme
Multi-step reaction with 3 steps
1: HOBT, DEC / dimethylformamide / 24 h / 25 °C
2: TFA / CH2Cl2 / 24 h / 25 °C
3: 82 percent / CH2Cl2 / 48 h / 25 °C
View Scheme
3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-one
193276-55-0

3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-one

lonafarnib
193275-84-2

lonafarnib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 84 percent / zinc dust; acetic anhydride; trifluoroacetic acid / tetrahydrofuran / 24 h / -25 - 18 °C
2.1: lithium diisopropylamide*THF; quinine; water / toluene; cyclohexane / 21 h / 5 - 25 °C
2.2: 10.5 g / sulfuric acid / toluene / 4 h / 85 °C
3.1: 80 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide; toluene / 18 h / 20 °C
4.1: hydrochloric acid / ethanol / 6 h / 20 °C
5.1: 5.44 g / NaOH / ethanol; 1-methyl-pyrrolidin-2-one / 10 h / 110 °C / pH 9
View Scheme
(R)-(+)-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11-yl)-1-piperidine
193276-49-2

(R)-(+)-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11-yl)-1-piperidine

lonafarnib
193275-84-2

lonafarnib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 80 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide; toluene / 18 h / 20 °C
2: hydrochloric acid / ethanol / 6 h / 20 °C
3: 5.44 g / NaOH / ethanol; 1-methyl-pyrrolidin-2-one / 10 h / 110 °C / pH 9
View Scheme
Multi-step reaction with 3 steps
1: HOBT, DEC / dimethylformamide / 24 h / 25 °C
2: TFA / CH2Cl2 / 24 h / 25 °C
3: 82 percent / CH2Cl2 / 48 h / 25 °C
View Scheme
(+)-1,1-dimethylethyl<<<4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11(R)-yl)-1-piperidinyl>-carbonyl>-methyl>-1-piperidinecarboxylate
193276-76-5

(+)-1,1-dimethylethyl<<<4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11(R)-yl)-1-piperidinyl>-carbonyl>-methyl>-1-piperidinecarboxylate

lonafarnib
193275-84-2

lonafarnib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrochloric acid / ethanol / 6 h / 20 °C
2: 5.44 g / NaOH / ethanol; 1-methyl-pyrrolidin-2-one / 10 h / 110 °C / pH 9
View Scheme
Multi-step reaction with 2 steps
1: TFA / CH2Cl2 / 24 h / 25 °C
2: 82 percent / CH2Cl2 / 48 h / 25 °C
View Scheme
8-chloro-3,10-dibromo-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridine
272107-22-9

8-chloro-3,10-dibromo-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridine

lonafarnib
193275-84-2

lonafarnib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: lithium diisopropylamide*THF; quinine; water / toluene; cyclohexane / 21 h / 5 - 25 °C
1.2: 10.5 g / sulfuric acid / toluene / 4 h / 85 °C
2.1: 80 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide; toluene / 18 h / 20 °C
3.1: hydrochloric acid / ethanol / 6 h / 20 °C
4.1: 5.44 g / NaOH / ethanol; 1-methyl-pyrrolidin-2-one / 10 h / 110 °C / pH 9
View Scheme
ethyl 4-(3-bromo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate
165740-12-5

ethyl 4-(3-bromo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate

lonafarnib
193275-84-2

lonafarnib

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 86 percent / H2SO4, NaNO3 / 2 h / -5 °C
2: 85 percent / iron filings, CaCl2, H2O / ethanol / 16 h / Heating
3: 70 percent / Br2, AcOH / 16 h / Ambient temperature
4: 1.) conc HCl, NaNO2, 2.) 50 percent H3PO2 / 1.) from -10 deg C to 0 deg C, 2 h, 2.) RT, overnight
5: 93 percent / conc. HCl / 16 h / Heating
6: DIBAL-H / toluene / 0.67 h / Heating
8: HOBT, DEC / dimethylformamide / 24 h / 25 °C
9: TFA / CH2Cl2 / 24 h / 25 °C
10: 82 percent / CH2Cl2 / 48 h / 25 °C
View Scheme
(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11-yl)-1-piperidine
193276-48-1

(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11-yl)-1-piperidine

lonafarnib
193275-84-2

lonafarnib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
2: HOBT, DEC / dimethylformamide / 24 h / 25 °C
3: TFA / CH2Cl2 / 24 h / 25 °C
4: 82 percent / CH2Cl2 / 48 h / 25 °C
View Scheme
4-<3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11-ylidene>-1-piperidine
193276-47-0, 218453-59-9, 218453-60-2

4-<3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11-ylidene>-1-piperidine

lonafarnib
193275-84-2

lonafarnib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: DIBAL-H / toluene / 0.67 h / Heating
3: HOBT, DEC / dimethylformamide / 24 h / 25 °C
4: TFA / CH2Cl2 / 24 h / 25 °C
5: 82 percent / CH2Cl2 / 48 h / 25 °C
View Scheme
4-<3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11-ylidene>-1-piperidinecarboxylic acid ethyl ester
193276-46-9

4-<3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11-ylidene>-1-piperidinecarboxylic acid ethyl ester

lonafarnib
193275-84-2

lonafarnib

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 93 percent / conc. HCl / 16 h / Heating
2: DIBAL-H / toluene / 0.67 h / Heating
4: HOBT, DEC / dimethylformamide / 24 h / 25 °C
5: TFA / CH2Cl2 / 24 h / 25 °C
6: 82 percent / CH2Cl2 / 48 h / 25 °C
View Scheme
4-<3-bromo-8-chloro-5,6-dihydro-9-amino-11H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11-ylidene>-1-piperidinecarboxylic acid ethyl ester
193276-44-7

4-<3-bromo-8-chloro-5,6-dihydro-9-amino-11H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11-ylidene>-1-piperidinecarboxylic acid ethyl ester

lonafarnib
193275-84-2

lonafarnib

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 70 percent / Br2, AcOH / 16 h / Ambient temperature
2: 1.) conc HCl, NaNO2, 2.) 50 percent H3PO2 / 1.) from -10 deg C to 0 deg C, 2 h, 2.) RT, overnight
3: 93 percent / conc. HCl / 16 h / Heating
4: DIBAL-H / toluene / 0.67 h / Heating
6: HOBT, DEC / dimethylformamide / 24 h / 25 °C
7: TFA / CH2Cl2 / 24 h / 25 °C
8: 82 percent / CH2Cl2 / 48 h / 25 °C
View Scheme
4-<3-bromo-8-chloro-5,6-dihydro-9-nitro-11H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11-ylidene>-1-piperidinecarboxylic acid ethyl ester
193276-34-5

4-<3-bromo-8-chloro-5,6-dihydro-9-nitro-11H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11-ylidene>-1-piperidinecarboxylic acid ethyl ester

lonafarnib
193275-84-2

lonafarnib

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 85 percent / iron filings, CaCl2, H2O / ethanol / 16 h / Heating
2: 70 percent / Br2, AcOH / 16 h / Ambient temperature
3: 1.) conc HCl, NaNO2, 2.) 50 percent H3PO2 / 1.) from -10 deg C to 0 deg C, 2 h, 2.) RT, overnight
4: 93 percent / conc. HCl / 16 h / Heating
5: DIBAL-H / toluene / 0.67 h / Heating
7: HOBT, DEC / dimethylformamide / 24 h / 25 °C
8: TFA / CH2Cl2 / 24 h / 25 °C
9: 82 percent / CH2Cl2 / 48 h / 25 °C
View Scheme
4-<3,10-dibromo-8-chloro-5,6-dihydro-9-amino-11H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11-ylidene>-1-piperidinecarboxylic acid ethyl ester
193276-45-8

4-<3,10-dibromo-8-chloro-5,6-dihydro-9-amino-11H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11-ylidene>-1-piperidinecarboxylic acid ethyl ester

lonafarnib
193275-84-2

lonafarnib

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 1.) conc HCl, NaNO2, 2.) 50 percent H3PO2 / 1.) from -10 deg C to 0 deg C, 2 h, 2.) RT, overnight
2: 93 percent / conc. HCl / 16 h / Heating
3: DIBAL-H / toluene / 0.67 h / Heating
5: HOBT, DEC / dimethylformamide / 24 h / 25 °C
6: TFA / CH2Cl2 / 24 h / 25 °C
7: 82 percent / CH2Cl2 / 48 h / 25 °C
View Scheme
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