As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryOur advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the
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inquiryTRANS-3-HYDROXY-L-PROLINECAS:4298-08-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic i
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:4298-08-2
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryAppearance:light yellow powder Storage:Stored in a dark, cool, ventilated and dry place Package:NW 1kg/foil bag; 20-25kg/drum or carton Application:pharm intermediate Transportation:by air/sea/express,according to demand. Port:Shanghai/ Guangzhou/an
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:4298-08-2
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inquiryTRANS-3-HYDROXY-L-PROLINEAppearance:White to pale beige powder Storage:Keep away from fire and heat Package:according to customers' requirements Application:For Research Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or
Superior quality, moderate price & quick delivery. Appearance:White to light beige powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used
Cas:4298-08-2
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inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Cas:4298-08-2
Min.Order:10 Gram
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Cas:4298-08-2
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inquiryWe product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Product Name:TRANS-3-HYDROXY-L-PROLINE CAS No:4298-
factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:4298-08-2
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inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
Cas:4298-08-2
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:4298-08-2
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe
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inquiryGOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
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inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
Cas:4298-08-2
Min.Order:0
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Type:Lab/Research institutions
inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates
(2S,3S)-N-benzyl-2-hydroxyproline
trans-3-hydroxy-L-proline
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In methanol at 20℃; for 13h; | 98% |
trans-3-hydroxy-L-proline
Conditions | Yield |
---|---|
With hydrogenchloride In water at 20℃; for 16h; | 89% |
trans-3-hydroxy-L-proline
Conditions | Yield |
---|---|
With potassium hydroxide In methanol; water Ambient temperature; | 88% |
Potassium; (2S,3S)-2-amino-3-hydroxy-5,5-dimethoxy-pentanoate
trans-3-hydroxy-L-proline
Conditions | Yield |
---|---|
With hydrogen; trifluoroacetic acid; platinum(IV) oxide In ethanol; water for 15h; Ambient temperature; | 87% |
trans-3-hydroxy-L-proline
Conditions | Yield |
---|---|
With hydrogenchloride In water at 20℃; for 16h; | 87% |
(2S,3S)-1-(tert-butoxycarbonyl)-3-(tert-butyldimethylsiloxy)pyrrolidine-2-carboxylic acid
trans-3-hydroxy-L-proline
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol for 3h; Inert atmosphere; Reflux; | 80% |
With hydrogenchloride for 3h; Heating; | 70% |
A
threo-β-hydroxy-L-glutamic acid (threo-L-BHGA)
B
(R)-β-hydroxypalmitic acid
C
trans-3-hydroxy-L-proline
D
4R-4-hydroxyproline
Conditions | Yield |
---|---|
With hydrogenchloride at 110℃; for 16h; | A 14.7 mg B 19 mg C 14.2 mg D 15.6 mg |
trans-3-hydroxy-L-proline
Conditions | Yield |
---|---|
With Dowex 50W-X8; water In tetrahydrofuran Heating; | 0.14 g |
Conditions | Yield |
---|---|
With α-ketoglutaric acid; iron(II) sulfate; ascorbic acid; Aeromonas caviae In water at 25℃; for 24h; pH=7; Enzymatic reaction; |
trans-3-hydroxy-L-proline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 83 percent / aq. hydrochloric acid / 8 h / 45 - 50 °C 2: 98 percent / H2 / Pd-C / methanol / 13 h / 20 °C View Scheme |
methyl (2S,3S)-3-hydroxy-2-[(9-phenyl-9-fluorenyl)-amino]-4-pentenoate
trans-3-hydroxy-L-proline
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 98 percent / imidazole / dimethylformamide / 12 h / 20 °C 2.1: BH3*SMe2 / tetrahydrofuran / 10 h / 20 °C 2.2: 70 percent / NaOH; aq. H2O2 / tetrahydrofuran 3.1: 87 percent / MsCl; Et3N / tetrahydrofuran / 3 h / 0 °C 4.1: H2 / Pd/C / methanol / 3 h / 60 °C 5.1: 0.14 g / Dowex 50W-X8; H2O / tetrahydrofuran / Heating View Scheme |
trans-3-hydroxy-L-proline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Amberlyst 15 / 65 °C 2: 70 percent / 1.) Pd(dba)2, Dppb, mercaptobenzoic acid, 2.) 1M HCl / tetrahydrofuran / Ambient temperature 3: 88 percent / KOH / methanol; H2O / Ambient temperature View Scheme |
(2S,3S)-1-Allyl-3-hydroxy-pyrrolidine-2-carboxylic acid methyl ester
trans-3-hydroxy-L-proline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 70 percent / 1.) Pd(dba)2, Dppb, mercaptobenzoic acid, 2.) 1M HCl / tetrahydrofuran / Ambient temperature 2: 88 percent / KOH / methanol; H2O / Ambient temperature View Scheme |
(2R,3S)-1-Allyl-3-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-2-carbonitrile
trans-3-hydroxy-L-proline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: HCl / methanol / -20 °C 2: Amberlyst 15 / 65 °C 3: 70 percent / 1.) Pd(dba)2, Dppb, mercaptobenzoic acid, 2.) 1M HCl / tetrahydrofuran / Ambient temperature 4: 88 percent / KOH / methanol; H2O / Ambient temperature View Scheme |
(3R,7aS)-3-phenyl-3,7a-dihydro-1H-pyrrolo[1,2-c]oxazol-5-one
trans-3-hydroxy-L-proline
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 63 percent / t-BuOOH, n-Bu4NF, K2CO3 / dimethylformamide; 2,2,4-trimethyl-pentane; tetrahydrofuran / 2 h 2: 79 percent / aluminum amalgam, NaHCO3 (half sat.) / ethanol; acetone / 2 h 3: 74 percent / imidazole / dimethylformamide / 6 h / 40 °C 4: 1.) BH3*SMe, 2.) TMEDA / 1.) THF, 70 deg C, 2 h, 2.) THF, Et2O, RT, 6 h 5: 80 percent / H2 / 10percent Pd/C / methanol / 3 h / 15001.2 Torr 6: 51 percent / NaIO4, RuCl3 / acetonitrile; CCl4; H2O / 1.5 h / Ambient temperature 7: 70 percent / 6 M aq. HCl / 3 h / Heating View Scheme |
(3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one
trans-3-hydroxy-L-proline
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: 1.) n-BuLi, hexamethyldisilazane / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 2 h 2: 30percent aq. H2O2 / ethyl acetate / 0.67 h / 0 - 22 °C 3: 63 percent / t-BuOOH, n-Bu4NF, K2CO3 / dimethylformamide; 2,2,4-trimethyl-pentane; tetrahydrofuran / 2 h 4: 79 percent / aluminum amalgam, NaHCO3 (half sat.) / ethanol; acetone / 2 h 5: 74 percent / imidazole / dimethylformamide / 6 h / 40 °C 6: 1.) BH3*SMe, 2.) TMEDA / 1.) THF, 70 deg C, 2 h, 2.) THF, Et2O, RT, 6 h 7: 80 percent / H2 / 10percent Pd/C / methanol / 3 h / 15001.2 Torr 8: 51 percent / NaIO4, RuCl3 / acetonitrile; CCl4; H2O / 1.5 h / Ambient temperature 9: 70 percent / 6 M aq. HCl / 3 h / Heating View Scheme |
bicyclic (2R,5R,6R)-6-hydroxy-2-phenyl-3-oxa-1-azabicyclo<3.3.0>octan-8-one
trans-3-hydroxy-L-proline
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 74 percent / imidazole / dimethylformamide / 6 h / 40 °C 2: 1.) BH3*SMe, 2.) TMEDA / 1.) THF, 70 deg C, 2 h, 2.) THF, Et2O, RT, 6 h 3: 80 percent / H2 / 10percent Pd/C / methanol / 3 h / 15001.2 Torr 4: 51 percent / NaIO4, RuCl3 / acetonitrile; CCl4; H2O / 1.5 h / Ambient temperature 5: 70 percent / 6 M aq. HCl / 3 h / Heating View Scheme |
(2R,3S)-1-benzyl-3-tert-butyldimethylsilyloxy-2-hydroxymethylpyrrolidine
trans-3-hydroxy-L-proline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 80 percent / H2 / 10percent Pd/C / methanol / 3 h / 15001.2 Torr 2: 51 percent / NaIO4, RuCl3 / acetonitrile; CCl4; H2O / 1.5 h / Ambient temperature 3: 70 percent / 6 M aq. HCl / 3 h / Heating View Scheme |
tert-butyl (2R,3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-(hydroxymethyl)pyrrolidine-1-carboxylate
trans-3-hydroxy-L-proline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 51 percent / NaIO4, RuCl3 / acetonitrile; CCl4; H2O / 1.5 h / Ambient temperature 2: 70 percent / 6 M aq. HCl / 3 h / Heating View Scheme |
(2R,5R,6S)-6-tert-butyldimethylsiloxy-3-oxa-2-phenyl-1-azabicyclo<3.3.0>octane-8-one
trans-3-hydroxy-L-proline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) BH3*SMe, 2.) TMEDA / 1.) THF, 70 deg C, 2 h, 2.) THF, Et2O, RT, 6 h 2: 80 percent / H2 / 10percent Pd/C / methanol / 3 h / 15001.2 Torr 3: 51 percent / NaIO4, RuCl3 / acetonitrile; CCl4; H2O / 1.5 h / Ambient temperature 4: 70 percent / 6 M aq. HCl / 3 h / Heating View Scheme |
trans-3-hydroxy-L-proline
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 30percent aq. H2O2 / ethyl acetate / 0.67 h / 0 - 22 °C 2: 63 percent / t-BuOOH, n-Bu4NF, K2CO3 / dimethylformamide; 2,2,4-trimethyl-pentane; tetrahydrofuran / 2 h 3: 79 percent / aluminum amalgam, NaHCO3 (half sat.) / ethanol; acetone / 2 h 4: 74 percent / imidazole / dimethylformamide / 6 h / 40 °C 5: 1.) BH3*SMe, 2.) TMEDA / 1.) THF, 70 deg C, 2 h, 2.) THF, Et2O, RT, 6 h 6: 80 percent / H2 / 10percent Pd/C / methanol / 3 h / 15001.2 Torr 7: 51 percent / NaIO4, RuCl3 / acetonitrile; CCl4; H2O / 1.5 h / Ambient temperature 8: 70 percent / 6 M aq. HCl / 3 h / Heating View Scheme |
(2R,5R,6R,7R)-6,7-epoxy-2-phenyl-3-oxa-1-aza-bicyclo<3.3.0>octane-8-one
trans-3-hydroxy-L-proline
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 79 percent / aluminum amalgam, NaHCO3 (half sat.) / ethanol; acetone / 2 h 2: 74 percent / imidazole / dimethylformamide / 6 h / 40 °C 3: 1.) BH3*SMe, 2.) TMEDA / 1.) THF, 70 deg C, 2 h, 2.) THF, Et2O, RT, 6 h 4: 80 percent / H2 / 10percent Pd/C / methanol / 3 h / 15001.2 Torr 5: 51 percent / NaIO4, RuCl3 / acetonitrile; CCl4; H2O / 1.5 h / Ambient temperature 6: 70 percent / 6 M aq. HCl / 3 h / Heating View Scheme |
A
L-erythro-3-amino-butane-1,2,4-triol
B
L-serin
C
L-threonine
D
L-arginine
E
2-(S)-amino-3-(R)-hydroxysuccinic acid
F
trans-3-hydroxy-L-proline
G
L-proline
H
(R)-3-hydroxy-13-methyltetradecanoic acid
Conditions | Yield |
---|---|
With hydrogenchloride; water for 20h; Reflux; |
A
L-serin
B
L-threonine
C
(2S,3S)-3-amino-2,4-dihydroxy-butyric acid
D
L-arginine
E
2-amino-2-deoxy-L-erythronic acid
F
trans-3-hydroxy-L-proline
G
L-proline
H
(R)-3-hydroxy-13-methyltetradecanoic acid
Conditions | Yield |
---|---|
With hydrogenchloride; water for 20h; Reflux; |
A
L-serin
B
L-threonine
C
L-arginine
D
L-threo-3-hydroxyaspartic acid
E
2-(S)-amino-3-(R)-hydroxysuccinic acid
F
trans-3-hydroxy-L-proline
G
L-proline
H
(R)-3-hydroxy-13-methyltetradecanoic acid
Conditions | Yield |
---|---|
With hydrogenchloride; water for 20h; Reflux; |
Conditions | Yield |
---|---|
With His-tagged eukaryotic α-ketoglutarate/FeII-dependent proline hydroxylase F from Glarea lozoyensis ATCC 74030; ascorbate; α-ketoglutarate; iron(II) sulfate In aq. buffer at 20℃; for 1h; pH=6; Kinetics; Enzymatic reaction; stereoselective reaction; |
trans-3-hydroxy-L-proline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 25% Pd(OH)2/C; acetic acid / methanol; water / 20 °C / 3800.26 Torr 2: hydrogenchloride / water / 16 h / 20 °C View Scheme |
di-tert-butyl dicarbonate
trans-3-hydroxy-L-proline
(2S,3S)-1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide In tetrahydrofuran at 20℃; | 100% |
With sodium hydroxide In tetrahydrofuran; water | 100% |
With sodium hydroxide In tetrahydrofuran | 92% |
methanol
trans-3-hydroxy-L-proline
(2S,3S)-methyl 3-hydroxypyrrolidine-2-carboxylate
Conditions | Yield |
---|---|
With thionyl chloride | 100% |
With thionyl chloride | |
With hydrogenchloride |
Conditions | Yield |
---|---|
With thionyl chloride at 0 - 20℃; | 100% |
With hydrogenchloride at 0 - 20℃; | 99% |
With thionyl chloride at 0℃; for 16h; | 99% |
(fluorenylmethoxy)carbonyl chloride
trans-3-hydroxy-L-proline
(2S,3S)-(3-hydroxy)pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In 1,4-dioxane at 0 - 20℃; for 9h; | 98% |
With sodium hydrogencarbonate In 1,4-dioxane at 0 - 20℃; for 9h; | 98% |
With sodium carbonate In 1,4-dioxane; water at 0 - 20℃; for 3h; | 59% |
With sodium carbonate In 1,4-dioxane; water at 0 - 20℃; for 3h; | 59.2% |
With sodium hydrogencarbonate In 1,4-dioxane; water at 4 - 20℃; for 10h; | 58% |
methanol
di-tert-butyl dicarbonate
trans-3-hydroxy-L-proline
(2S,3S)-1-tert-butyl-2-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate
Conditions | Yield |
---|---|
Stage #1: methanol; trans-3-hydroxy-L-proline With thionyl chloride at 0 - 20℃; for 16h; Stage #2: di-tert-butyl dicarbonate With triethylamine In dichloromethane at 20℃; for 2h; | 96% |
di-tert-butyl dicarbonate
benzyl bromide
trans-3-hydroxy-L-proline
2-benzyl 1-(tert-butyl) (2S,3S)-3-hydroxypyrrolidine-1,2-dicarboxylate
Conditions | Yield |
---|---|
Stage #1: di-tert-butyl dicarbonate; trans-3-hydroxy-L-proline With sodium hydroxide; water In tetrahydrofuran at 20℃; for 19h; Stage #2: With hydrogenchloride In tetrahydrofuran; water Stage #3: benzyl bromide With hydrogenchloride; potassium hydrogencarbonate more than 3 stages; | 91% |
Conditions | Yield |
---|---|
With acetyl chloride at 0 - 65℃; for 6h; | 91% |
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile
trans-3-hydroxy-L-proline
(2S,3S)-1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane; methanol; water at 20℃; for 4h; | 88% |
With sodium hydroxide In 1,4-dioxane; water at 0℃; for 12h; |
N-Fmoc L-Phe
trans-3-hydroxy-L-proline
(2S,3S)-1-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionyl]-3-hydroxy-pyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: N-Fmoc L-Phe With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 4h; Stage #2: trans-3-hydroxy-L-proline With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; | 88% |
trans-3-hydroxy-L-proline
benzyl chloroformate
(2S,3S)-1-((benzyloxy)carbonyl)-3-hydroxypyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water for 20h; | 78% |
With N-ethyl-N,N-diisopropylamine In water; N,N-dimethyl-formamide at 0 - 20℃; | |
With sodium hydrogencarbonate |
tert-butyldicarbonate
trans-3-hydroxy-L-proline
(2S,3S)-1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water for 24h; | 75% |
Conditions | Yield |
---|---|
In dichloromethane at -78 - 20℃; for 72h; | 72% |
methanol
trityl chloride
trans-3-hydroxy-L-proline
(2S,3S)-1-(triphenylmethyl)-3-hydroxyproline methyl ester
Conditions | Yield |
---|---|
Stage #1: methanol; trans-3-hydroxy-L-proline With thionyl chloride Stage #2: trityl chloride With triethylamine In dichloromethane at 0 - 20℃; | 72% |
Conditions | Yield |
---|---|
Stage #1: trans-3-hydroxy-L-proline; isobutene With toluene-4-sulfonic acid In dichloromethane at -78 - 20℃; for 72h; Stage #2: With sodium hydroxide In dichloromethane; water at 0℃; for 4h; Stage #3: With hydrogenchloride In dichloromethane; water at 0℃; for 0.5h; | 69% |
trans-3-hydroxy-L-proline
1H,2H,4H-thieno[2,3-d][1,3]oxazine-2,4-dione
(8S,8aS)-8-hydroxy-6,7,8,8a-tetrahydro-4H-pyrrolo[1,2-a]thieno[2,3-e][1,4]diazepine-4,9(10H)-dione
Conditions | Yield |
---|---|
In water Reflux; regioselective reaction; | 35% |
trans-3-hydroxy-L-proline
2-aminobenzaldehyde
1,2,3,3a,4,9-hexahydro-pyrrolo[2,1-b]quinazolin-3-ol
Conditions | Yield |
---|---|
In butan-1-ol at 150℃; for 0.25h; Microwave irradiation; Sealed tube; regioselective reaction; | 11% |
3,5-dichlorobenzensulfonyl chloride
trans-3-hydroxy-L-proline
(2S,3S)-1-(3,5-Dichloro-benzenesulfonyl)-3-hydroxy-pyrrolidine-2-carboxylic acid
Conditions | Yield |
---|---|
With sodium carbonate In water at 20℃; |
trans-3-hydroxy-L-proline
(2S,3R)-N-tert-Butyloxycarbonyl-3-benzoyloxy-2-pyrrolidinecarboxylic Acid Methyl Ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 99 percent / HCl / 0 - 20 °C 2: 80 percent / Et3N / CH2Cl2 / 0 - 20 °C 3: 90 percent / PPh3; DEAD / tetrahydrofuran / 9 h / 0 - 20 °C View Scheme |
trans-3-hydroxy-L-proline
(2S,3S)-N-tert-butyloxycarbonyl-3-(tert-butyldimethylsilyloxy)-2-pyrrolidinecarboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 99 percent / HCl / 0 - 20 °C 2: 80 percent / Et3N / CH2Cl2 / 0 - 20 °C 3: 90 percent / i-Pr2NEt / DMAP / CH2Cl2 / 48 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: acetyl chloride / 6 h / 0 - 65 °C 2: sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C 3: 1H-imidazole / N,N-dimethyl-formamide / 3.5 h View Scheme | |
Multi-step reaction with 3 steps 1: acetyl chloride / 20 h / 0 - 65 °C 2: sodium hydrogencarbonate / tetrahydrofuran / 10 h / 0 - 20 °C 3: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: acetyl chloride / 0 - 65 °C / Cooling with ice bath; Inert atmosphere 2: sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C / Inert atmosphere; Cooling with ice bath 3: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride / 6.17 h / 0 - 20 °C 2: triethylamine / dichloromethane / 0 - 20 °C 3: 1H-imidazole / dichloromethane / 20 °C View Scheme |
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