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Jinon Pharma (Wuhan) Co., Ltd.

1. best service, high quality and reasonable price 2. it's customers' right to choose the package (ems, dhl, fedex, ups); 3. it's customers' right to choose the packing way for his products from many recent effective pac

3-Trifluoromethylbenzylcyanide

Cas:2338-76-3

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

3-Trifluoromethylbenzylcyanide Manufacturer/High quality/Best price/In stock

Cas:2338-76-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Jinan Finer Chemical Co., Ltd

Product description: Product name 3-Trifluoromethylbenzylcyanide CAS number 2338-76-3 Assay ≥99% Appearance Colorless transparent liquid Capacity 200mt/year Application Pharm

3-Trifluoromethylbenzylcyanide

Cas:2338-76-3

Min.Order:100 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Henan Allgreen Chemical Co.,Ltd

Located in Zhengdong New District, Zhengzhou of Henan province, Henan Allgreen Chemical Co.,Ltd is comprehensive high-tech modern enterprises integrating professional R&D, production and sales. Strong technical force, with a long-term professio

3-TrifluoroMethylbenzylcyanide

Cas:2338-76-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

3-(Trifluoromethyl)Phenylacetonitrile

Cas:2338-76-3

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-(Trifluoromethyl)-phenylacetonitrile

Cas:2338-76-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

3-(TrifluoroMethyl)phenylacetonitrile

Cas:2338-76-3

Min.Order:5 Metric Ton

FOB Price: $360.0 / 400.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 2338-76-3 with best quality

Cas:2338-76-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name:3-Trifluoromethylbenzylcyanide Other name: 3-(Trifluoromethyl)phenylacetonitrile Synonyms:2-[3-(Trifluoromethyl)phenyl]acetonitrile Cas: 2338-76-3 EINECS: 219-053-8 Keywords:3-trifluoromethylbenzylcyanide;3-(Trifluoromethyl)phenylace

3-Trifluoromethylbenzylcyanide CAS No.: 2338-76-3

Cas:2338-76-3

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Benzeneacetonitrile,3-(trifluoromethyl)-

Cas:2338-76-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

3-Trifluoromethylbenzylcyanide CAS:2338-76-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality org

3-Trifluoromethylbenzylcyanide CAS:2338-76-3

Cas:2338-76-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzeneacetonitrile,3-(trifluoromethyl)-

Cas:2338-76-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:2338-76-3

Cas:2338-76-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

3-(Trifluoromethyl)benzyl cyanide cas:2338-76-3

Cas:2338-76-3

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

3-(Trifluoromethyl)benzyl cyanide

Cas:2338-76-3

Min.Order:1 Kilogram

FOB Price: $6.0 / 10.0

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-(Trifluoromethyl)phenylacetonitrile

Cas:2338-76-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

3,4,5-Triiodobenzoic acid

Cas:2338-76-3

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3-(trifluoromethyl)phenylacetonitrile

Cas:2338-76-3

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

3-(TrifluoroMethyl)phenylacetonitrile

Cas:2338-76-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

3-Trifluoromethylbenzylcyanide,2338-76-3

Cas:2338-76-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: 3-(Trifluoromethyl)Phenylacetonitrile CAS No.:2338-76-3 Molecule Formula:C9H6F3N Molecule Weight:185.14 Purity: 99% Package: 25kg/drum Description:Yellow liquid Manufacture Standards:Enterprise Standard TESTING ITEM

High Quality 3-(Trifluoromethyl)Phenylacetonitrile in stock

Cas:2338-76-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

3-Trifluoromethylbenzylcyanide

Cas:2338-76-3

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermediat

3-(Trifluoromethyl)benzyl cyanide

Cas:2338-76-3

Min.Order:1 Kilogram

FOB Price: $5.0 / 15.0

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

3-Trifluoromethylbenzylcyanide

Cas:2338-76-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Henan Kanbei Chemical Co.,LTD

High quality, competitive price, fast delivery and first-class service we possesses have won the trust and praise of customers. Standard: BP/USP/EP The purity is equal or greater than 99%. As a supplier, we can provide high-quality products. Cle

hot sale 3-(Trifluoromethyl)phenylacetonitrile

Cas:2338-76-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

3-(Trifluoromethyl)phenylacetonitrile

Cas:2338-76-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:light yellow liquid Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Inter

3-Trifluoromethylbenzylcyanide

Cas:2338-76-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

3-(Trifluoromethyl)Phenylacetonitrile cas no. 2338-76-3 98%

Cas:2338-76-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

3-(trifluoromethyl)phenylacetonitrile

Cas:2338-76-3

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

3-(TrifluoroMethyl)phenylacetonitrile

Cas:2338-76-3

Min.Order:0

Negotiable

Type:Manufacturers

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Synthetic route

potassium cyanide
151-50-8

potassium cyanide

1-bromomethyl-3-trifluoromethylbenzene
402-23-3

1-bromomethyl-3-trifluoromethylbenzene

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

Conditions
ConditionsYield
In ethanol; water for 1.5h; Heating / reflux;100%
In dimethyl sulfoxide
sodium cyanide
773837-37-9

sodium cyanide

3-Trifluoromethylbenzyl chloride
705-29-3

3-Trifluoromethylbenzyl chloride

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride In water at 55 - 65℃; for 10h; Temperature;91%
3-chlorotrifluoromethylbenzene
98-15-7

3-chlorotrifluoromethylbenzene

ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

Conditions
ConditionsYield
Stage #1: 3-chlorotrifluoromethylbenzene; ethyl 2-cyanoacetate With N-(2-methylnaphthalen-1-yl)-N’-(pyridin-2-ylmethyl)oxalamide; copper(I) bromide; sodium t-butanolate In isopropyl alcohol at 105℃; for 24h; Schlenk technique; Inert atmosphere;
Stage #2: With water In isopropyl alcohol at 105℃; for 12h; Schlenk technique; Inert atmosphere; Cooling;
71%
potassium cyanide
151-50-8

potassium cyanide

3-Trifluoromethylbenzyl chloride
705-29-3

3-Trifluoromethylbenzyl chloride

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

Conditions
ConditionsYield
With potassium iodide In methanol
(+/-)-ethyl cyano[3-(trifluoromethyl)phenyl]acetate
91322-61-1

(+/-)-ethyl cyano[3-(trifluoromethyl)phenyl]acetate

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

Conditions
ConditionsYield
With sulfuric acid In water; acetic acid at 80 - 90℃; for 3h; Yield given;
sodium cyanide
143-33-9

sodium cyanide

3-Trifluoromethylbenzyl chloride
705-29-3

3-Trifluoromethylbenzyl chloride

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

C9H5F3NNa

C9H5F3NNa

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

Conditions
ConditionsYield
With methanol In dimethyl sulfoxide at 25℃; Equilibrium constant;
sodium cyanide
143-33-9

sodium cyanide

1-bromomethyl-3-trifluoromethylbenzene
402-23-3

1-bromomethyl-3-trifluoromethylbenzene

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

1-methyl-3-trifluoromethyl-benzene
401-79-6

1-methyl-3-trifluoromethyl-benzene

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NBS
View Scheme
3-bromo-1-trifluoromethylbenzene
401-78-5

3-bromo-1-trifluoromethylbenzene

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaH, CuI / hexamethylphosphoric acid triamide / 5 h / 150 - 160 °C
2: H2SO4 / H2O; acetic acid / 3 h / 80 - 90 °C
View Scheme
3-(trifluoromethyl)benzyl alcohol
349-75-7

3-(trifluoromethyl)benzyl alcohol

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (bromination)
2: dimethylsulfoxide
View Scheme
3-(trifluoromethyl)phenylmagnesium bromide
402-26-6

3-(trifluoromethyl)phenylmagnesium bromide

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
2: (bromination)
3: dimethylsulfoxide
View Scheme
3-Trifluoromethylbenzyl chloride
705-29-3

3-Trifluoromethylbenzyl chloride

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

Conditions
ConditionsYield
In dimethyl sulfoxide
In dimethyl sulfoxide
In dimethyl sulfoxide
(α,α,α-trifluoro-m-tolyl)acetamide
22902-93-8

(α,α,α-trifluoro-m-tolyl)acetamide

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

Conditions
ConditionsYield
In acetonitrile
In acetonitrile
1-Bromo-2-chloroethane
107-04-0

1-Bromo-2-chloroethane

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

1-(3-(trifluoromethyl)phenyl)cyclopropane-1-carbonitrile

1-(3-(trifluoromethyl)phenyl)cyclopropane-1-carbonitrile

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 50℃;100%
With benzyltriethylammonium bromide; sodium hydroxide In water; toluene at 0 - 20℃; for 96h; Inert atmosphere;72%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 50℃;
ethylene dibromide
106-93-4

ethylene dibromide

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

1-(3-(trifluoromethyl)phenyl)cyclopropane-1-carbonitrile

1-(3-(trifluoromethyl)phenyl)cyclopropane-1-carbonitrile

Conditions
ConditionsYield
Stage #1: 3-trifluoromethylphenylacetonitrile With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.166667h;
Stage #2: ethylene dibromide In N,N-dimethyl-formamide at 20℃; for 3h;
100%
2-Aminonicotinaldehyde
7521-41-7

2-Aminonicotinaldehyde

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

3-[3-(trifluoromethyl)phenyl][1,8]naphthyridin-2-amine
1082325-94-7

3-[3-(trifluoromethyl)phenyl][1,8]naphthyridin-2-amine

Conditions
ConditionsYield
With potassium hydroxide for 0.0416667h; Microwave irradiation;98%
phenylacetyl chloride
103-80-0

phenylacetyl chloride

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

(3-trifluoromethylphenyl)benzylcarbonylacetonitrile
68084-26-4

(3-trifluoromethylphenyl)benzylcarbonylacetonitrile

Conditions
ConditionsYield
With sodium t-butanolate In tetrahydrofuran at 10℃; for 24h; Reagent/catalyst; Solvent; Temperature; Autoclave;94.1%
methyl 2-bromo-3-methylbutanoic ester
69367-52-8, 70332-52-4, 114528-93-7, 26330-51-8

methyl 2-bromo-3-methylbutanoic ester

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

methyl 2-isopropyl-3-oxo-4-(3-trifluoromethylphenyl)butyrate
1015701-13-9

methyl 2-isopropyl-3-oxo-4-(3-trifluoromethylphenyl)butyrate

Conditions
ConditionsYield
With zinc In tetrahydrofuran for 0.5h; Heating;94%
3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

3-trifluoromethylbenzamide
1801-10-1

3-trifluoromethylbenzamide

Conditions
ConditionsYield
With ammonium hydroxide; ruthenium-carbon composite In tetrahydrofuran at 30℃; for 25h; Time;94%
With ammonium hydroxide; 5 wt% ruthenium/carbon; oxygen In tetrahydrofuran at 30℃; for 25h;94%
naphthalen-2-yl tosylate
7385-85-5

naphthalen-2-yl tosylate

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

2-(naphthalen-2-yl)-2-(3-(trifluoromethyl)phenyl)acetonitrile

2-(naphthalen-2-yl)-2-(3-(trifluoromethyl)phenyl)acetonitrile

Conditions
ConditionsYield
With potassium phosphate; palladium diacetate; XPhos In dichloromethane; tert-butyl alcohol at 110℃; for 4h; Inert atmosphere; Schlenk technique; Sealed tube;93%
3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

2-(3-(trifluoromethyl)phenyl)ethanethioamide
952182-78-4

2-(3-(trifluoromethyl)phenyl)ethanethioamide

Conditions
ConditionsYield
With hydrogenchloride; O,O-Diethyl hydrogen phosphorodithioate In ethyl acetate at 20℃; Product distribution / selectivity;92%
With hydrogenchloride; O,O-Diethyl hydrogen phosphorodithioate In ethyl acetate at 0 - 20℃;65%
cyclohexylamine
108-91-8

cyclohexylamine

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

N-cyclohexyl-3-(trifluoromethyl)benzamide
418795-69-4

N-cyclohexyl-3-(trifluoromethyl)benzamide

Conditions
ConditionsYield
With 5 wt% ruthenium/carbon; oxygen In tetrahydrofuran at 30℃; for 23h;92%
3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

2-bromobutyric acid ethyl ester
533-68-6

2-bromobutyric acid ethyl ester

ethyl 2-ethyl-3-oxo-4-(3-trifluoromethylphenyl)butyrate
1015701-12-8

ethyl 2-ethyl-3-oxo-4-(3-trifluoromethylphenyl)butyrate

Conditions
ConditionsYield
With zinc In tetrahydrofuran for 0.5h; Heating;91%
methyllithium
917-54-4

methyllithium

1,2-Epoxy-3-bromopropane
3132-64-7

1,2-Epoxy-3-bromopropane

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

3-hydroxy-1-[3-(trifluoromethyl)phenyl]cyclobutanecarbonitrile
1432050-72-0

3-hydroxy-1-[3-(trifluoromethyl)phenyl]cyclobutanecarbonitrile

Conditions
ConditionsYield
Stage #1: methyllithium; 3-trifluoromethylphenylacetonitrile In tetrahydrofuran; diethyl ether at -75℃; for 1h;
Stage #2: 1,2-Epoxy-3-bromopropane In tetrahydrofuran; diethyl ether at -75℃; for 1h;
Stage #3: With hydrogenchloride; methylmagnesium bromide In tetrahydrofuran; diethyl ether; water at -75 - 20℃;
91%
1,2-Epoxy-3-bromopropane
3132-64-7

1,2-Epoxy-3-bromopropane

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

3-hydroxy-1-[3-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile
1432050-56-0

3-hydroxy-1-[3-(trifluoromethoxy)phenyl]cyclobutanecarbonitrile

Conditions
ConditionsYield
Stage #1: 3-trifluoromethylphenylacetonitrile In tetrahydrofuran; diethyl ether at -75℃; for 1h;
Stage #2: 1,2-Epoxy-3-bromopropane In tetrahydrofuran; diethyl ether at -75℃; for 1h;
Stage #3: With hydrogenchloride; methylmagnesium bromide In tetrahydrofuran; diethyl ether; water at -75 - 20℃;
91%
1,2-Epoxy-3-bromopropane
3132-64-7

1,2-Epoxy-3-bromopropane

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

3-hydroxy-1-[3-(trifluoromethyl)phenyl]cyclobutanecarbonitrile
1432050-72-0

3-hydroxy-1-[3-(trifluoromethyl)phenyl]cyclobutanecarbonitrile

Conditions
ConditionsYield
Stage #1: 3-trifluoromethylphenylacetonitrile With methyllithium In tetrahydrofuran; diethyl ether at -75℃; for 1h;
Stage #2: 1,2-Epoxy-3-bromopropane In tetrahydrofuran; diethyl ether at -75℃; for 1h;
Stage #3: With methylmagnesium bromide In tetrahydrofuran; diethyl ether at 20℃;
91%
Stage #1: 3-trifluoromethylphenylacetonitrile With methyllithium In tetrahydrofuran; diethyl ether at -75℃; for 1h;
Stage #2: 1,2-Epoxy-3-bromopropane With methylmagnesium bromide In tetrahydrofuran; diethyl ether at -75℃; for 1h;
Stage #3: With methylmagnesium bromide In tetrahydrofuran; diethyl ether at -75 - 20℃; for 16h;
91%
3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

1,2,3,4-tetrahydroquinoline-8-carboxylic acid methyl ester

1,2,3,4-tetrahydroquinoline-8-carboxylic acid methyl ester

3-amino-2-(3-trifluoromethylphenyl)-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinolin-1-one

3-amino-2-(3-trifluoromethylphenyl)-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinolin-1-one

Conditions
ConditionsYield
With pyridine; sodium t-butanolate for 6h; Reflux;90%
piperidine
110-89-4

piperidine

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

(piperidin-1-yl)(3-(trifluoromethyl)phenyl)methanone
69001-08-7

(piperidin-1-yl)(3-(trifluoromethyl)phenyl)methanone

Conditions
ConditionsYield
With 5 wt% ruthenium/carbon; oxygen In tetrahydrofuran at 30℃; for 21h;88%
ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
4506-71-2

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

2-(3-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydrothieno[2,3-d]pyrimidin-4(3H)-one

2-(3-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydrothieno[2,3-d]pyrimidin-4(3H)-one

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane at 20℃; for 18h;88%
3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

3-(trifluoromethyl)phenylacetic acid
351-35-9

3-(trifluoromethyl)phenylacetic acid

Conditions
ConditionsYield
Stage #1: 3-trifluoromethylphenylacetonitrile With sodium hydroxide; water Heating / reflux;
Stage #2: With hydrogenchloride In water pH=2;
87%
With sodium hydroxide In ethanol
With sulfuric acid; acetic acid
salicylaldehyde
90-02-8

salicylaldehyde

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

4-methyl-N-(3-(3-(trifluoromethyl)phenyl)-2H-chromen-2-ylidene)benzenesulfonamide

4-methyl-N-(3-(3-(trifluoromethyl)phenyl)-2H-chromen-2-ylidene)benzenesulfonamide

Conditions
ConditionsYield
Stage #1: salicylaldehyde; 3-trifluoromethylphenylacetonitrile With 1,4-diaza-bicyclo[2.2.2]octane In 2-methyltetrahydrofuran at 80℃; for 8h; Reflux;
Stage #2: p-toluenesulfonyl chloride With 1,4-diaza-bicyclo[2.2.2]octane In 2-methyltetrahydrofuran at 0℃;
87%
3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

C18H8F6N2

C18H8F6N2

Conditions
ConditionsYield
With 5% active carbon-supported ruthenium; potassium carbonate In 1,2-dichloro-benzene at 160℃; for 35h;87%
With methanol; iodine; sodium In diethyl ether at -78 - 0℃; for 2.25h; Inert atmosphere;65%
2-hydroxy-4,6-dimethoxybenzaldehyde
708-76-9

2-hydroxy-4,6-dimethoxybenzaldehyde

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

5,7-dimethoxy-3-(3'-trifluoromethylphenyl)iminocoumarin

5,7-dimethoxy-3-(3'-trifluoromethylphenyl)iminocoumarin

Conditions
ConditionsYield
With Amberlite IRA 900 (OH-) In cyclohexane for 15h; Condensation; Heating;85%
3-oxa-1,5-dichloropentane
111-44-4

3-oxa-1,5-dichloropentane

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

4-(3-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carbonitrile
1035261-83-6

4-(3-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carbonitrile

Conditions
ConditionsYield
In N,N-dimethyl-formamide; mineral oil at 20 - 55℃; for 21.5h; Inert atmosphere;85%
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20 - 55℃; for 21.5h;85%
Stage #1: 3-trifluoromethylphenylacetonitrile With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Cooling with ice;
Stage #2: 3-oxa-1,5-dichloropentane In N,N-dimethyl-formamide at 0℃; for 0.5h;
84%
Stage #1: 3-trifluoromethylphenylacetonitrile With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 0.5h; Cooling with ice;
Stage #2: 3-oxa-1,5-dichloropentane In N,N-dimethyl-formamide at 20℃; for 2h;
Stage #3: With lithium chloride In N,N-dimethyl-formamide
84%
Stage #1: 3-trifluoromethylphenylacetonitrile With potassium tert-butylate In N,N-dimethyl-formamide at 0℃; for 0.166667h;
Stage #2: 3-oxa-1,5-dichloropentane In N,N-dimethyl-formamide at 0 - 20℃; for 6h;
N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

N,N-dimethyl 3-(trifluoromethyl)benzamide
90238-10-1

N,N-dimethyl 3-(trifluoromethyl)benzamide

Conditions
ConditionsYield
With copper(I) oxide; 1,10-Phenanthroline; oxygen; toluene-4-sulfonic acid at 140℃; under 760.051 Torr; for 24h; Sealed tube;84%
benzyl alcohol
100-51-6

benzyl alcohol

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

3-phenyl-2-(3-(trifluoromethyl)phenyl)propanamide

3-phenyl-2-(3-(trifluoromethyl)phenyl)propanamide

Conditions
ConditionsYield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; triphenylphosphine; potassium hydroxide In tert-Amyl alcohol at 130℃; for 2h; Microwave irradiation;84%
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; triphenylphosphine; potassium hydroxide at 130℃; for 2h; Microwave irradiation; Green chemistry;84%
carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

methyl (3-trifluoromethylphenyl)cyanoacetate

methyl (3-trifluoromethylphenyl)cyanoacetate

Conditions
ConditionsYield
With sodium methylate In methanol; toluene at 75 - 80℃; for 12h;83%
salicylaldehyde
90-02-8

salicylaldehyde

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

3-(3-(trifluoromethyl)phenyl)-2H-chromen-2-imine

3-(3-(trifluoromethyl)phenyl)-2H-chromen-2-imine

Conditions
ConditionsYield
Stage #1: salicylaldehyde With amberlite IRA-900 form OH In toluene at 85℃; for 3h; Inert atmosphere;
Stage #2: 3-trifluoromethylphenylacetonitrile In toluene for 12h; Reflux; Inert atmosphere;
83%
4-[(E)-2-{4-[(E)-2-(4-formylphenyl)ethenyl]-2,5-bis(octyloxy)phenyl}ethenyl]benzaldehyde
370563-61-4

4-[(E)-2-{4-[(E)-2-(4-formylphenyl)ethenyl]-2,5-bis(octyloxy)phenyl}ethenyl]benzaldehyde

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

(2Z)-3-[4-{(E)-2-[4-{(E)-2-[4-{(Z)-2-cyano-2-[3-(trifluoromethyl)phenyl]ethenyl}phenyl]ethenyl}-2,5-bis(octyloxy)phenyl]ethenyl}phenyl]-2-[3-(trifluoromethyl)phenyl]-2-propenenitrile

(2Z)-3-[4-{(E)-2-[4-{(E)-2-[4-{(Z)-2-cyano-2-[3-(trifluoromethyl)phenyl]ethenyl}phenyl]ethenyl}-2,5-bis(octyloxy)phenyl]ethenyl}phenyl]-2-[3-(trifluoromethyl)phenyl]-2-propenenitrile

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran; tert-butyl alcohol79%
Knoevenagel condensation;
triethylbenzylammonium chloride (TEBA)

triethylbenzylammonium chloride (TEBA)

ethylene dibromide
106-93-4

ethylene dibromide

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

1-(3-(trifluoromethyl)phenyl)cyclopropane-1-carbonitrile

1-(3-(trifluoromethyl)phenyl)cyclopropane-1-carbonitrile

Conditions
ConditionsYield
With sodium hydroxide79%
naphthalen-2-yl methanesulfonate
10290-91-2

naphthalen-2-yl methanesulfonate

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

2-(naphthalen-2-yl)-2-(3-(trifluoromethyl)phenyl)acetonitrile

2-(naphthalen-2-yl)-2-(3-(trifluoromethyl)phenyl)acetonitrile

Conditions
ConditionsYield
With potassium phosphate; palladium diacetate; XPhos In dichloromethane; tert-butyl alcohol at 110℃; for 4h; Inert atmosphere; Schlenk technique; Sealed tube;79%

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