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Yichang Chanod Biomedical Technology Co,LTD

Appearance:White powder Storage:Dryness Factor (< 25℃) Package:1KG;10KG;100KG Application:pharmaceutical intermediates Transportation:By sea or by air Port:Shang hai

Propanoic acid,3-bromo-2-hydroxy-2-methyl-, (2R)-

Cas:261904-39-6

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material&#39;s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid

Cas:261904-39-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality (2R)-3-Bromo-2-Hydroxy-2-Methylpropanoic Acid supplier in China

Cas:261904-39-6

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

Propanoic acid,3-bromo-2-hydroxy-2-methyl-, (2R) manufacturer/supplier

Cas:261904-39-6

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&amp;D team masters core technology for process-design of target building block

(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid

Cas:261904-39-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 261904-39-6 with competitive price

Cas:261904-39-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the &quot;product quality&quot; and &quot;After Service&quot; Upbio is Specialized

(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid 261904-39-6

Cas:261904-39-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid CAS:261904-39-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing i

(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid CAS:261904-39-6

Cas:261904-39-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I&#39;m Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company&#39;s products and services. If you are interested in our products, please contact us by emai

(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid

Cas:261904-39-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid

Cas:261904-39-6

Min.Order:1 Kilogram

FOB Price: $30.0 / 50.0

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality &amp; Attractive price &amp; Professional service; Trial &amp; Pilot &amp; Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

(2R)-3-Bromo-2-Hydroxy-2-Methylpropanoic Acid

Cas:261904-39-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

(2R)-3-bromo-2-hydroxy-2-methyl-propanoic acid

Cas:261904-39-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Propanoic acid,3-bromo-2-hydroxy-2-methyl-, (2R)-

Cas:261904-39-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Beijing Greenchem Technology Co.,Ltd. ( Panjin Greenchem Technology Co.Ltd .)

Capability on chemical synthesis 1. Beijing High-Tech Enterprises 2. Strong R&amp;D Team 3. 10 years of experiences in R &amp; D of high-tech Catalyst; 4. 5000 production techniques, 69 items of national patents, and 360 kinds of product

(R)-3-bromo-2-hydroxy-2-methylpropanoic acid

Cas:261904-39-6

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&amp;H CHEM R&amp;D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&amp;H CHEM has some Manufacturing base in Jia

(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid

Cas:261904-39-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products (2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid

Cas:261904-39-6

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

cas:261904-39-6

Cas:261904-39-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(2R)-3-Bromo-2-hydroxy-2-methylpropionicaci

Cas:261904-39-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea

(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acidCAS NO.: 261904-39-6

Cas:261904-39-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&amp;D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid

Cas:261904-39-6

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid

Cas:261904-39-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

261904-39-6 CAS NO.261904-39-6

Cas:261904-39-6

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid

Cas:261904-39-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid

Cas:261904-39-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuxi TAA Chemical Industry Co.,LTD.

1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re

(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid CAS 261904-39-6

Cas:261904-39-6

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

high purity, manufacturer Application:Intermediate

(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid

Cas:261904-39-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

(2R)-3-Bromo-2-Hydroxy-2-Methylpropanoic Acid

Cas:261904-39-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Goodqualtiy Appearance:powder Storage:common Package:drum Application:intermediate Transportation:Meet buyer's requirement Port:Shanghai

(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid

Cas:261904-39-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid

Cas:261904-39-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

98% Appearance:White or off-white powder Storage:Room temperature preservation Package:Packaging according to customer requirements Application:used for medicine Transportation:by sea by air express Port:china port

(2R)-3-Bromo-2-hydroxy-2-methylpropanoic acid China manufacture 98%min

Cas:261904-39-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

(3R,8AR)-3-Bromomethyl-3-methyl-tetrahydro-pyrrolo[2,1-c][1,4]oxazine-1,4-dione
106138-80-1

(3R,8AR)-3-Bromomethyl-3-methyl-tetrahydro-pyrrolo[2,1-c][1,4]oxazine-1,4-dione

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

Conditions
ConditionsYield
With hydrogen bromide for 5h; Reflux;91.3%
With hydrogen bromide In water for 1h; Heating / reflux;86%
With water; hydrogen bromide for 1h; Heating / reflux;86%
(3R,8αR)-3-(bromomethyl)-3-methyl-tetrahydro-3H-pyrrolo[2,1-c][1,4]oxazine-1,4-dione

(3R,8αR)-3-(bromomethyl)-3-methyl-tetrahydro-3H-pyrrolo[2,1-c][1,4]oxazine-1,4-dione

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

Conditions
ConditionsYield
With water; hydrogen bromide for 1h; Heating / reflux;85%
With hydrogen bromide at 105℃; for 1.5h;84%
With hydrogen bromide In water at 105℃; Temperature; Large scale;
3-bromomethyl-3-methyl-tetrahydro-pyrrolo[2,1-c][1,4]oxazine-1,4-dione

3-bromomethyl-3-methyl-tetrahydro-pyrrolo[2,1-c][1,4]oxazine-1,4-dione

A

(2R)-3-chloro-2-hydroxy-2-methylpropanoic acid

(2R)-3-chloro-2-hydroxy-2-methylpropanoic acid

B

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

Conditions
ConditionsYield
With hydrogenchloride Hydrolysis; Heating; Title compound not separated from byproducts.;
C9H15BrO3
1250440-74-4

C9H15BrO3

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

Conditions
ConditionsYield
With hydrogenchloride In water for 4h; Reflux; Inert atmosphere;
With hydrogenchloride; water for 4h; Reflux;
(2R)-1-methacryloylpyrrolidin-2-carboxylic acid
106089-24-1

(2R)-1-methacryloylpyrrolidin-2-carboxylic acid

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

Conditions
ConditionsYield
Stage #1: (2R)-1-methacryloylpyrrolidin-2-carboxylic acid With N-Bromosuccinimide In N,N-dimethyl-formamide
Stage #2: With hydrogenchloride In water at 100℃;
3-pentafluorosulfuraniline
2993-22-8

3-pentafluorosulfuraniline

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

(R)-3-bromo-2-hydroxy-2-methyl-N-(3-(pentafluorosulfanyl)phenyl)propanamide

(R)-3-bromo-2-hydroxy-2-methyl-N-(3-(pentafluorosulfanyl)phenyl)propanamide

Conditions
ConditionsYield
Stage #1: (2R)-3-bromo-2-hydroxy-2-methylpropanoic acid With thionyl chloride In N,N-dimethyl acetamide at -10 - -5℃; for 3h; Inert atmosphere;
Stage #2: 3-pentafluorosulfuraniline In N,N-dimethyl acetamide at 20℃; for 16h; Inert atmosphere;
96%
5-amino-2-cyanopyridine
55338-73-3

5-amino-2-cyanopyridine

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

(2R)-3-bromo-N-(6-cyanopyridin-3-yl)-2-hydroxy-2-methylpropanamide

(2R)-3-bromo-N-(6-cyanopyridin-3-yl)-2-hydroxy-2-methylpropanamide

Conditions
ConditionsYield
With thionyl chloride; trimethylamine92%
Stage #1: (2R)-3-bromo-2-hydroxy-2-methylpropanoic acid With thionyl chloride In tetrahydrofuran at 0 - 12℃; for 2.166h;
Stage #2: With triethylamine In tetrahydrofuran at -5 - 12℃; for 0.333333h;
Stage #3: 5-amino-2-cyanopyridine In tetrahydrofuran at 50℃; for 2h;
85%
5-amino-3-(trifluoromethyl)-2-pyridinecarbonitrile
573762-62-6

5-amino-3-(trifluoromethyl)-2-pyridinecarbonitrile

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

(R)-3-bromo-N-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-2-hydroxy-2-methylpropanamide

(R)-3-bromo-N-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-2-hydroxy-2-methylpropanamide

Conditions
ConditionsYield
With thionyl chloride; trimethylamine90%
Stage #1: (2R)-3-bromo-2-hydroxy-2-methylpropanoic acid With thionyl chloride In tetrahydrofuran at 0 - 12℃; for 2.166h;
Stage #2: With triethylamine In tetrahydrofuran at -5 - 12℃; for 0.333333h;
Stage #3: 5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile In tetrahydrofuran at 50℃; for 2h;
85%
Stage #1: (2R)-3-bromo-2-hydroxy-2-methylpropanoic acid With thionyl chloride In tetrahydrofuran at 4℃; for 3h; Inert atmosphere;
Stage #2: With triethylamine In tetrahydrofuran at 4℃; for 0.333333h; Inert atmosphere;
Stage #3: 5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile In tetrahydrofuran at 20℃;
70.2%
bromal
115-17-3

bromal

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

C7H8Br4O3
1003838-02-5

C7H8Br4O3

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃;89%
4-amino-2-chlorobenzonitrile
20925-27-3

4-amino-2-chlorobenzonitrile

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

(2R)-3-bromo-N-(3-chloro-4-cyanophenyl)-2-hydroxy-2-methylpropanamide
1002330-78-0

(2R)-3-bromo-N-(3-chloro-4-cyanophenyl)-2-hydroxy-2-methylpropanamide

Conditions
ConditionsYield
Stage #1: (2R)-3-bromo-2-hydroxy-2-methylpropanoic acid With thionyl chloride In tetrahydrofuran at 0 - 12℃; for 2.166h;
Stage #2: With triethylamine In tetrahydrofuran at -5 - 12℃; for 0.333333h;
Stage #3: 4-amino-2-chlorobenzonitrile In tetrahydrofuran at 50℃; for 2h;
88.6%
Stage #1: (2R)-3-bromo-2-hydroxy-2-methylpropanoic acid With thionyl chloride In tetrahydrofuran at 4℃; for 3h; Inert atmosphere;
Stage #2: 4-amino-2-chlorobenzonitrile With triethylamine In tetrahydrofuran at 20℃;
73%
Stage #1: (2R)-3-bromo-2-hydroxy-2-methylpropanoic acid With thionyl chloride In tetrahydrofuran at 4℃; for 3h; Inert atmosphere;
Stage #2: In tetrahydrofuran for 0.333333h; Inert atmosphere;
Stage #3: 4-amino-2-chlorobenzonitrile In tetrahydrofuran at 20℃; Inert atmosphere;
73%
Stage #1: (2R)-3-bromo-2-hydroxy-2-methylpropanoic acid With thionyl chloride In tetrahydrofuran at 4℃; for 3h; Inert atmosphere;
Stage #2: 4-amino-2-chlorobenzonitrile With triethylamine In tetrahydrofuran at 20℃;
49.4%
With thionyl chloride In tetrahydrofuran at 0℃;
4-(pentafluorosulfanyl)aniline
2993-24-0

4-(pentafluorosulfanyl)aniline

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

(R)-3-bromo-2-hydroxy-2-methyl-N-(4-(pentafluorosulfanyl)phenyl)propanamide

(R)-3-bromo-2-hydroxy-2-methyl-N-(4-(pentafluorosulfanyl)phenyl)propanamide

Conditions
ConditionsYield
Stage #1: (2R)-3-bromo-2-hydroxy-2-methylpropanoic acid With thionyl chloride In N,N-dimethyl acetamide at -10 - -5℃; for 3h; Inert atmosphere;
Stage #2: 4-(pentafluorosulfanyl)aniline In N,N-dimethyl acetamide at 20℃; for 16h; Inert atmosphere;
88%
4-amino-2-trifluoromethylbenzonitrile
654-70-6

4-amino-2-trifluoromethylbenzonitrile

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

(2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide
206193-17-1

(2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide

Conditions
ConditionsYield
Stage #1: (2R)-3-bromo-2-hydroxy-2-methylpropanoic acid With thionyl chloride In N,N-dimethyl acetamide at -10℃; for 3h; Inert atmosphere;
Stage #2: 4-amino-2-trifluoromethylbenzonitrile In N,N-dimethyl acetamide at -10 - 20℃; for 16h; Inert atmosphere;
84%
Stage #1: (2R)-3-bromo-2-hydroxy-2-methylpropanoic acid With thionyl chloride In ISOPROPYLAMIDE at -10℃; Inert atmosphere;
Stage #2: 4-amino-2-trifluoromethylbenzonitrile In ISOPROPYLAMIDE at 20℃;
84%
With thionyl chloride In N,N-dimethyl acetamide at -15 - 40℃; for 3.5h;80.4%
ethanol
64-17-5

ethanol

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

(R)-3-bromo-2-hydroxy-2-methyl-propionic acid ethyl ester

(R)-3-bromo-2-hydroxy-2-methyl-propionic acid ethyl ester

Conditions
ConditionsYield
With toluene-4-sulfonic acid for 7h; Reflux;83%
4-nitro-3-(trifluoromethyl)benzeneamine
393-11-3

4-nitro-3-(trifluoromethyl)benzeneamine

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

N-[4-nitro-3-(trifluoromethyl)phenyl]-(2R)-3-bromo-2-hydroxy-2-methylpropanamide
206193-18-2

N-[4-nitro-3-(trifluoromethyl)phenyl]-(2R)-3-bromo-2-hydroxy-2-methylpropanamide

Conditions
ConditionsYield
With thionyl chloride In N,N-dimethyl acetamide at 20℃;80%
Stage #1: (2R)-3-bromo-2-hydroxy-2-methylpropanoic acid With thionyl chloride In dimethyl amine at -10 - -5℃; for 2h;
Stage #2: 4-nitro-3-(trifluoromethyl)benzeneamine In dimethyl amine at 20℃;
80%
Stage #1: (2R)-3-bromo-2-hydroxy-2-methylpropanoic acid With thionyl chloride In 2,4-dichlorophenoxyacetic acid dimethylamine at -10℃; for 2h;
Stage #2: 4-nitro-3-(trifluoromethyl)benzeneamine In 2,4-dichlorophenoxyacetic acid dimethylamine at 20℃;
80%
Stage #1: (2R)-3-bromo-2-hydroxy-2-methylpropanoic acid With thionyl chloride In tetrahydrofuran at 10℃; for 2.83333h; Inert atmosphere; Large scale;
Stage #2: 4-nitro-3-(trifluoromethyl)benzeneamine With triethylamine In tetrahydrofuran at 10 - 50℃; for 18.75h; Large scale;
70.3%
With thionyl chloride In N,N-dimethyl acetamide at -15 - 40℃; for 8.5h;57.2%
4-amino-5-iodo-2-(trifluoromethyl)benzonitrile
852569-35-8

4-amino-5-iodo-2-(trifluoromethyl)benzonitrile

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

(R)-3-bromo-N-(4-cyano-2-iodo-5-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

(R)-3-bromo-N-(4-cyano-2-iodo-5-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

Conditions
ConditionsYield
With thionyl chloride; triethylamine64.6%
4-amino-2-(pentafluorosulfanyl)benzonitrile
852469-69-3

4-amino-2-(pentafluorosulfanyl)benzonitrile

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

(R)-3-bromo-N-(4-cyano-3-(pentafluorosulfanyl)phenyl)-2-hydroxy-2-methylpropanamide

(R)-3-bromo-N-(4-cyano-3-(pentafluorosulfanyl)phenyl)-2-hydroxy-2-methylpropanamide

Conditions
ConditionsYield
Stage #1: (2R)-3-bromo-2-hydroxy-2-methylpropanoic acid With thionyl chloride In N,N-dimethyl acetamide at -10 - -5℃; for 3h; Inert atmosphere;
Stage #2: 4-amino-2-(pentafluorosulfanyl)benzonitrile In N,N-dimethyl acetamide at 20℃; for 16h; Inert atmosphere;
49%
4-Amino-2-chloropyridine
14432-12-3

4-Amino-2-chloropyridine

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

(R)-3-bromo-N-(2-chloropyridin-4-yl)-2-hydroxy-2-methylpropanamide

(R)-3-bromo-N-(2-chloropyridin-4-yl)-2-hydroxy-2-methylpropanamide

Conditions
ConditionsYield
Stage #1: (2R)-3-bromo-2-hydroxy-2-methylpropanoic acid With thionyl chloride In tetrahydrofuran at 4℃; for 3h; Inert atmosphere;
Stage #2: With triethylamine In tetrahydrofuran at 4℃; for 0.333333h;
Stage #3: 4-Amino-2-chloropyridine In tetrahydrofuran at 4 - 20℃;
43%
2-fluorophenol
367-12-4

2-fluorophenol

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

C10H11FO4
1578263-99-6

C10H11FO4

Conditions
ConditionsYield
With potassium carbonate In butanone for 16h; Reflux;15%
(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

(R)-3-bromo-2-hydroxy-2-methylpropanoyl chloride
1010396-30-1

(R)-3-bromo-2-hydroxy-2-methylpropanoyl chloride

Conditions
ConditionsYield
With thionyl chloride In tetrahydrofuran at 0℃;
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at -10 - -5℃; for 3h;
With thionyl chloride In tetrahydrofuran at 0℃;
bromoacid

bromoacid

4-nitro-3-(trifluoromethyl)benzeneamine
393-11-3

4-nitro-3-(trifluoromethyl)benzeneamine

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

N-[4-nitro-3-(trifluoromethyl)phenyl]-(2R)-3-bromo-2-hydroxy-2-methylpropanamide
206193-18-2

N-[4-nitro-3-(trifluoromethyl)phenyl]-(2R)-3-bromo-2-hydroxy-2-methylpropanamide

Conditions
ConditionsYield
With thionyl chloride In 2,4-dichlorophenoxyacetic acid dimethylamine18.0 g (80%)
With thionyl chloride In 2,4-dichlorophenoxyacetic acid dimethylamine18.0 g (80%)
With thionyl chloride In 2,4-dichlorophenoxyacetic acid dimethylamine18.0 g (80%)
dimethyl amine
124-40-3

dimethyl amine

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

C6H13NO3
936910-33-7

C6H13NO3

Conditions
ConditionsYield
In tetrahydrofuran at 0℃; for 2h;
4-nitro-3-methylaniline
611-05-2

4-nitro-3-methylaniline

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

(2R)-3-bromo-2-hydroxy-2-methyl-N-(3-methyl-4-nitrophenyl)propionamide
821764-69-6

(2R)-3-bromo-2-hydroxy-2-methyl-N-(3-methyl-4-nitrophenyl)propionamide

Conditions
ConditionsYield
Stage #1: (2R)-3-bromo-2-hydroxy-2-methylpropanoic acid With thionyl chloride In ISOPROPYLAMIDE at -10 - -5℃; for 2h; Heating / reflux;
Stage #2: 4-nitro-3-methylaniline In ISOPROPYLAMIDE at 20℃; for 3h;
CH2Cl2/EtOAc

CH2Cl2/EtOAc

4-amino-2-trifluoromethylbenzonitrile
654-70-6

4-amino-2-trifluoromethylbenzonitrile

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

A

(2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide
206193-17-1

(2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide

B

(3R,8AR)-3-Bromomethyl-3-methyl-tetrahydro-pyrrolo[2,1-c][1,4]oxazine-1,4-dione
106138-80-1

(3R,8AR)-3-Bromomethyl-3-methyl-tetrahydro-pyrrolo[2,1-c][1,4]oxazine-1,4-dione

Conditions
ConditionsYield
With thionyl chloride; triethylamine In tetrahydrofuran; waterA n/a
B 55.8 g (73.9%)
CH2Cl2/EtOAc

CH2Cl2/EtOAc

4-amino-2-trifluoromethylbenzonitrile
654-70-6

4-amino-2-trifluoromethylbenzonitrile

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

(2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide
206193-17-1

(2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide

Conditions
ConditionsYield
With thionyl chloride; triethylamine In tetrahydrofuran; water55.8 g (73.9%)
4-Fluorophenol
371-41-5

4-Fluorophenol

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

C10H11FO4

C10H11FO4

Conditions
ConditionsYield
With potassium carbonate In butanone for 16h; Reflux;
4-Fluorothiophenol
371-42-6

4-Fluorothiophenol

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

(R)-3-(4-fluorophenylmercapto)-2-hydroxy-2-methylpropionic acid
335595-52-3

(R)-3-(4-fluorophenylmercapto)-2-hydroxy-2-methylpropionic acid

Conditions
ConditionsYield
With sodium hydroxide In isopropyl alcohol
6-amino-quinazoline
101421-72-1

6-amino-quinazoline

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid
261904-39-6

(2R)-3-bromo-2-hydroxy-2-methylpropanoic acid

(R)-3-bromo-2-hydroxy-2-methyl-N-(quinazolin-6-yl) propanamide

(R)-3-bromo-2-hydroxy-2-methyl-N-(quinazolin-6-yl) propanamide

Conditions
ConditionsYield
With thionyl chloride; trimethylamine0.71 g

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