As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:30766-11-1
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryUnique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white powder Storage:Cool dry place Package:1kg/foill bag;25kg/drum Application:
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryName: 5-Bromo-2-Pyridinecarboxlic Acid Synonyms: 5-bromo-2-pyridine carboxlic acid CAS: 30766-11-1 MF: C6H3BrNO2 Appearance:Colorless clear liquid Storage:Preserve in well-closed, light-resistant and airtight containers. Package:25kg/drum A
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/1811.html Product Name 5-Bromopyridine-2-carboxylic acid CAS No. 307
Cas:30766-11-1
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryProduct Name: 5-Bromopyridine-2-carboxylic acid CAS: 30766-11-1 MF: C6H4BrNO2 MW: 202.01 EINECS: 640-263-4 Mol File: 30766-11-1.mol 5-Bromopyridine-2-carboxylic acid Structure 5-Bromopyridine-2-carboxylic acid Chemical Properties
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
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inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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Cas:30766-11-1
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inquiry5-Bromopyridine-2-Carboxylic AcidAppearance:white powder 5-Bromopyridine-2-carboxylic acid Storage:in dry cool place 5-Bromopyridine-2-carboxylic acid Package:according to customers' requirements Application:5-Bromopyridine-2-carboxylic acid has wide
We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:30766-11-1
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inquirySuperior quality Appearance:white Cryst Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceutical Intermediates Transportation:BY AIR
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inquiryProduct name: 5-Bromopyridine-2-Carboxylic Acid CAS No.:30766-11-1 Molecule Formula:C6H3BrNO2 Molecule Weight:201.00 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard
Cas:30766-11-1
Min.Order:1 Kilogram
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquirytert-butyl 5-bromopyridine-2-carboxylate
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
In hexafluoropropan-2-ol at 100℃; for 3h; Microwave irradiation; | 95% |
methyl 5-bromopicolinate
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
With sodium hydroxide In tetrahydrofuran at 0 - 20℃; for 15h; | 90% |
With lithium hydroxide monohydrate In tetrahydrofuran; water at 20℃; | |
With sodium hydroxide In water at 20℃; for 12h; |
Conditions | Yield |
---|---|
With n-butyllithium In hexane; toluene at -75℃; for 2h; | 64% |
Stage #1: 2,5-dibromopyridine With n-butyllithium In toluene at -78℃; for 2h; Stage #2: carbon dioxide In toluene at -78℃; for 1h; Stage #3: With hydrogenchloride In water; toluene | 47% |
Stage #1: 2,5-dibromopyridine With n-butyllithium In toluene at -78℃; for 2h; Stage #2: carbon dioxide In toluene at -78℃; for 1h; | 47% |
2-Cyano-5-bromopyridine
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
With hydrogenchloride In water Reflux; | 64% |
With hydrogenchloride for 24h; Heating; | |
Stage #1: 2-Cyano-5-bromopyridine With potassium hydroxide; ethanol; water at 80℃; for 24h; Stage #2: With hydrogenchloride; water pH=4; |
5-bromo-2-methylpyridine
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
With potassium permanganate In water at 80℃; | 39% |
With potassium permanganate | |
With potassium permanganate; water at 100℃; for 6h; | |
With potassium permanganate Heating; |
5-amino-pyridine-2-carboxylic acid
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
With hydrogen sulfide; hydrogen bromide; urea; copper(I) bromide; sodium nitrite 1) H2O, 0 deg C, 5 min; 0 deg C, 10 min; 2) 0 deg C, 10 min; reflux; Yield given. Multistep reaction; |
5-nitro-pyridin-2-ylamine
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 1.) 48 percent HBr, Br2; 2.) NaNO2 / 1) 30-40 deg C; 2) -5 deg C, H2O; 10-15 Deg C, 90 min.; 3) 40 deg C. 15 min 2: dimethylsulfoxide / 0.08 h / 180 °C 3: 54 percent / HCl / 1.5 h / Heating 4: 70 percent / H2S, 25 percent NH3 5: 1) 24 percent HBr, NaNO2, urea; 2) CuBr, 48 percent HBr, H2S / 1) H2O, 0 deg C, 5 min; 0 deg C, 10 min; 2) 0 deg C, 10 min; reflux View Scheme |
2-bromo-5-nitropyridine
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: dimethylsulfoxide / 0.08 h / 180 °C 2: 54 percent / HCl / 1.5 h / Heating 3: 70 percent / H2S, 25 percent NH3 4: 1) 24 percent HBr, NaNO2, urea; 2) CuBr, 48 percent HBr, H2S / 1) H2O, 0 deg C, 5 min; 0 deg C, 10 min; 2) 0 deg C, 10 min; reflux View Scheme |
5-nitropyridine-2-carbonitrile
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 54 percent / HCl / 1.5 h / Heating 2: 70 percent / H2S, 25 percent NH3 3: 1) 24 percent HBr, NaNO2, urea; 2) CuBr, 48 percent HBr, H2S / 1) H2O, 0 deg C, 5 min; 0 deg C, 10 min; 2) 0 deg C, 10 min; reflux View Scheme |
5-nitropicolinic acid
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 70 percent / H2S, 25 percent NH3 2: 1) 24 percent HBr, NaNO2, urea; 2) CuBr, 48 percent HBr, H2S / 1) H2O, 0 deg C, 5 min; 0 deg C, 10 min; 2) 0 deg C, 10 min; reflux View Scheme |
5-Amino-2-methylpyridine
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid 2: aqueous KMnO4 View Scheme |
6-methylnicotinamide
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: NaOCl; aqueous KOH 2: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid 3: aqueous KMnO4 View Scheme |
ethyl 6-methylnicotinate
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: aqueous NH3 2: NaOCl; aqueous KOH 3: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid 4: aqueous KMnO4 View Scheme | |
Multi-step reaction with 6 steps 1: N2H4+H2O 2: KNO2; aqueous HCl 4: aqueous KOH 5: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid 6: aqueous KMnO4 View Scheme |
6-methylpyridine-3-carbohydrazide
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: KNO2; aqueous HCl 3: aqueous KOH 4: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid 5: aqueous KMnO4 View Scheme |
6-methyl-nicotinoyl azide
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 2: aqueous KOH 3: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid 4: aqueous KMnO4 View Scheme |
(6-methyl-[3]pyridyl)-carbamic acid ethyl ester
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: aqueous KOH 2: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid 3: aqueous KMnO4 View Scheme |
1,3-bis(6-methylpyridin-3-yl)urea
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: concentrated aqueous HCl / 130 °C 2: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid 3: aqueous KMnO4 View Scheme |
C6H3BrNO2(1-)*Na(1+)
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
With water; acetic acid at 25℃; for 16h; |
5-bromo-pyridine-2-carbaldehyde
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
Stage #1: 5-bromo-pyridine-2-carbaldehyde With potassium permanganate; sodium carbonate In water at 10 - 20℃; Stage #2: With hydrogenchloride In water pH=2 - 4; | |
With 1,4-dithio-D,L-threitol; recombinant aldehyde dehydrogenase from Escherichia coli; water‐forming NADH oxidase from Streptococcus mutans; NAD In aq. phosphate buffer at 40℃; for 4h; pH=8.5; Reagent/catalyst; Green chemistry; Enzymatic reaction; chemoselective reaction; |
2,5-dibromopyridine
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: trimethylsilylmethyllithium / toluene / 0.5 h / -78 - 0 °C 1.2: 3 h 1.3: 18 h / 20 °C 2.1: sodium hydroxide / tetrahydrofuran / 15 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: trimethylsilylmethyllithium / toluene / 0.5 h / -78 - 0 °C 1.2: 3 h 1.3: 18 h / 20 °C 2.1: sodium hydroxide / tetrahydrofuran / 15 h / 0 - 20 °C View Scheme |
5-bromo-pyridine-2-carboxylic acid ethyl ester
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
With sodium hydroxide In tetrahydrofuran at 0 - 20℃; for 15h; |
5-bromoisonicotinic acid
ethanol
5-bromo-pyridine-2-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With thionyl chloride at 20℃; for 18h; | 100% |
With sulfuric acid at 75℃; for 2h; | 86% |
Stage #1: 5-bromoisonicotinic acid With thionyl chloride for 2h; Heating / reflux; Stage #2: ethanol In toluene Heating / reflux; Stage #3: With sodium carbonate In water; toluene pH=8; | 28% |
5-bromoisonicotinic acid
5-bromopyridine-2-carbonyl chloride
Conditions | Yield |
---|---|
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 2h; | 100% |
With thionyl chloride; N,N-dimethyl-formamide at 80℃; for 2h; | 99% |
With thionyl chloride for 2h; Inert atmosphere; Reflux; | 93% |
5-bromoisonicotinic acid
5-bromo-2-carboxypyridin-1-ium-1-olate
Conditions | Yield |
---|---|
Stage #1: 5-bromoisonicotinic acid With urea hydrogen peroxide adduct; trifluoroacetic anhydride In acetonitrile at 0℃; for 4.5h; Stage #2: With sodium thiosulfate In water; acetonitrile at 0℃; for 0.166667h; | 100% |
Stage #1: 5-bromoisonicotinic acid With urea hydrogen peroxide adduct; trifluoroacetic anhydride In acetonitrile at 0℃; for 4.5h; Stage #2: With sodium thiosulfate In water; acetonitrile for 0.166667h; | |
With dihydrogen peroxide; urea; trifluoroacetic anhydride In acetonitrile at 0℃; for 0.5h; | 19.6 g |
With dihydrogen peroxide; urea; trifluoroacetic anhydride In acetonitrile at 0℃; for 0.5h; | 19.6 g |
Stage #1: 5-bromoisonicotinic acid With urea hydrogen peroxide adduct In acetonitrile at 0℃; for 0.333333h; Stage #2: With trifluoroacetic anhydride In acetonitrile at 20℃; |
5-bromoisonicotinic acid
tert-butyl 4-[6-(dimethoxyboryl)-4H-1,3-benzodioxin-2-yl]piperidine-1-carboxylate
5-{2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-4H-1,3-benzodioxin-6-yl}pyridine-2-carboxylic acid
Conditions | Yield |
---|---|
With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In water; acetonitrile at 160℃; for 0.333333h; Irradiation; | 100% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Inert atmosphere; | 100% |
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
Stage #1: 5-bromoisonicotinic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h; Stage #2: ethyl 2-(furan-2-yl)-5-(trifluoromethyl)piperidine-3-carboxylate With triethylamine In dichloromethane at 0 - 20℃; | 99% |
5-bromoisonicotinic acid
2,3,4,5,6-pentafluorophenol
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2h; | 98% |
Conditions | Yield |
---|---|
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 12h; | 96% |
Conditions | Yield |
---|---|
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 12h; | 96% |
Conditions | Yield |
---|---|
With thionyl chloride at -78 - 20℃; for 16.1667h; | 95% |
5-bromoisonicotinic acid
1-t-Butoxycarbonylpiperazine
Conditions | Yield |
---|---|
With 4-methyl-morpholine; HATU In N,N-dimethyl-formamide at 20℃; | 95% |
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
With 1-hydroxy-7-aza-benzotriazole; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 25h; Inert atmosphere; | 95% |
5-bromoisonicotinic acid
tri-n-butyl(vinyl)tin
5-vinylpyridine-2-carboxylic acid
Conditions | Yield |
---|---|
bis-triphenylphosphine-palladium(II) chloride In 1,4-dioxane at 20 - 100℃; Inert atmosphere; | 94.5% |
5-bromoisonicotinic acid
1-ethynyl-3-fluoro-benzene
5-(3-fluoro-phenylethynyl)-pyridine-2-carboxylic acid
Conditions | Yield |
---|---|
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); diethylamine In N,N-dimethyl-formamide at 90℃; for 0.75h; Sonogashira Cross-Coupling; Microwave irradiation; | 94% |
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); diethylamine In N,N-dimethyl-formamide at 90℃; for 0.75h; Microwave irradiation; | 71% |
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine In N,N-dimethyl-formamide at 90℃; for 0.75h; Sonogashira Cross-Coupling; Inert atmosphere; | 65% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; | 93.3% |
5-bromoisonicotinic acid
2-methoxyethylamine
Conditions | Yield |
---|---|
Stage #1: 5-bromoisonicotinic acid; 2-methoxyethylamine With pyridine In dichloromethane at 0℃; for 0.166667h; Stage #2: With trichlorophosphate In dichloromethane at 0 - 20℃; for 1h; | 93% |
Conditions | Yield |
---|---|
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 4h; Inert atmosphere; | 93% |
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 22℃; for 17h; Inert atmosphere; | 93% |
5-bromoisonicotinic acid
5-bromo-2-pyridinecarboxamide
Conditions | Yield |
---|---|
Stage #1: 5-bromoisonicotinic acid With thionyl chloride; N,N-dimethyl-formamide In dichloromethane at 80℃; for 1h; Stage #2: With ammonium hydroxide In dichloromethane at 20℃; for 1.5h; | 92.4% |
With ammonium hydroxide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 1h; | 73% |
Stage #1: 5-bromoisonicotinic acid With thionyl chloride; N,N-dimethyl-formamide In tetrahydrofuran at 0 - 23℃; for 1h; Stage #2: With ammonia In tetrahydrofuran; water at 0℃; for 0.5h; | 50% |
Stage #1: 5-bromoisonicotinic acid With thionyl chloride for 3h; Reflux; Stage #2: With ammonia In tetrahydrofuran; water at 20℃; Cooling with ice; | |
Stage #1: 5-bromoisonicotinic acid With thionyl chloride for 3h; Reflux; Stage #2: With ammonia In tetrahydrofuran; water Cooling with ice; | 43 g |
Conditions | Yield |
---|---|
With sulfuric acid at 0 - 70℃; for 6h; | 92% |
Stage #1: methanol; 5-bromoisonicotinic acid With thionyl chloride at 20℃; for 3h; Reflux; Stage #2: With sodium hydrogencarbonate pH=7; | 86.9% |
With sulfuric acid for 117h; Reflux; | 86% |
5-bromoisonicotinic acid
tert-butylamine
Conditions | Yield |
---|---|
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 20℃; for 16h; | 92% |
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 20℃; for 16h; | 92% |
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 20℃; for 16h; | 92% |
5-bromoisonicotinic acid
dimethyl amine
5-bromo-2-(N,N-dimethylaminocarbonyl)pyridine
Conditions | Yield |
---|---|
Stage #1: 5-bromoisonicotinic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h; Stage #2: dimethyl amine With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; dichloromethane at 20℃; for 3h; | 91.7% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 18h; | |
With oxalyl dichloride In dichloromethane at 0 - 40℃; for 1h; | |
Stage #1: 5-bromoisonicotinic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 16h; Stage #2: dimethyl amine In dichloromethane at 0 - 20℃; for 3h; | |
Stage #1: 5-bromoisonicotinic acid With oxalyl dichloride In dichloromethane at 40℃; for 1h; Stage #2: dimethyl amine With N-ethyl-N,N-diisopropylamine In dichloromethane for 1h; |
5-bromoisonicotinic acid
methoxycarbonylmethylamine
methyl (5-bromopyridine-2-carbonyl)glycinate
Conditions | Yield |
---|---|
With thionyl chloride; N-ethyl-N,N-diisopropylamine | 90% |
5-bromoisonicotinic acid
N,N-diethylethylenediamine
5-bromo-N-(2-(diethylamino)ethyl)picolinamide
Conditions | Yield |
---|---|
Stage #1: 5-bromoisonicotinic acid With O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 60℃; for 3h; Stage #2: N,N-diethylethylenediamine In N,N-dimethyl-formamide at 20℃; for 2h; | 90% |
4-ethylpiperazine
5-bromoisonicotinic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 24h; | 89% |
1-(2-hydroxyethyl)piperazine
5-bromoisonicotinic acid
(5-bromopyridin-2-yl)(4-hydroxyethylpiperazin-1-yl)methanone
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 24h; | 88% |
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h; | 65% |
5-bromoisonicotinic acid
cyclobutylamine
5-bromo-N-cyclobutylpicolinamide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 4h; | 88% |
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