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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2,5-Bis(Trifluoromethyl)Aniline

Cas:328-93-8

Min.Order:0

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Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

2,5-Bis(trifluoromethyl)aniline

Cas:328-93-8

Min.Order:1 Kilogram

FOB Price: $3.0

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2,5-Bis(Trifluoromethyl)Aniline supplier in China

Cas:328-93-8

Min.Order:0 Metric Ton

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Wuhan Fortuna Chemical Co.,Ltd

Manufacturer supply 2,5-Bis(trifluoromethyl)aniline CAS 328-93-8 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed addi

Manufacturer supply 2,5-Bis(trifluoromethyl)aniline CAS 328-93-8

Cas:328-93-8

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Jinan Finer Chemical Co., Ltd

Product description: Product name 2,5-Bis(trifluoromethyl)aniline CAS number 328-93-8 Assay ≥99% Appearance Colorless transparent liquid Capacity 200mt/year Application Organ

2,5-Bis(trifluoromethyl)aniline

Cas:328-93-8

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2,5-Bis(Trifluoromethyl)Aniline

Cas:328-93-8

Min.Order:1

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Type:Other

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Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

2,5-Bis(trifluoromethyl)aniline

Cas:328-93-8

Min.Order:1 Kilogram

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

2,5-Bis(trifluoromethyl)aniline

Cas:328-93-8

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2,5-Bis-(trifluoromethyl)-aniline

Cas:328-93-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

2,5-Bis(trifluoromethyl)aniline Basic information Product Name: 2,5-Bis(trifluoromethyl)aniline Synonyms: ALPHA,ALPHA,ALPHA,ALPHA',ALPHA',ALPHA'-HEXAFLUORO-2,5-XYLIDINE;2,5-D

2,5-Bis(trifluoromethyl)aniline

Cas:328-93-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 328-93-8 with best quality

Cas:328-93-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

2,5-Bis(trifluoromethyl)aniline

Cas:328-93-8

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2,5-Bis(trifluoromethyl)aniline 328-93-8

Cas:328-93-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

2,5-Bis(trifluoromethyl)aniline

Cas:328-93-8

Min.Order:1 Kilogram

FOB Price: $88.0 / 100.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High quality 2,5-Bis(trifluoromethyl)aniline CAS 328-93-8 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2

High quality 2,5-Bis(trifluoromethyl)aniline CAS 328-93-8

Cas:328-93-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2,5-Bis(trifluoromethyl)aniline

Cas:328-93-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

2,5-Bis(trifluoromethyl)aniline/ LIDE PHARMA- Factory supply / Best price

Cas:328-93-8

Min.Order:0

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Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

2,5-bis(trifluoromethyl)aniline/Manufacturer/High quality/Best price

Cas:328-93-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:328-93-8

Cas:328-93-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

2,5-Bis(trifluoromethyl)aniline

Cas:328-93-8

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Triumph International Development Limilted

Appearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:As customer request Port:Qingda

2,5-Di(trifluoromethyl)aniline 328-93-8

Cas:328-93-8

Min.Order:1 Kilogram

FOB Price: $20.0

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2,5-Bis(trifluoromethyl)aniline

Cas:328-93-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2,5-Bis(trifluoromethyl)aniline

Cas:328-93-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

2,5-BIS(TRIFLUOROMETHYL)ANILINE

Cas:328-93-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2,5-bis(trifluoromethyl)aniline/Manufacturer/High quality/Best price

Cas:328-93-8

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2,5-Bis(trifluoromethyl)aniline

Cas:328-93-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

2,5-bis(trifluoromethyl)aniline/Manufacturer/High quality/Best price

Cas:328-93-8

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2,5-Bis(trifluoromethyl)aniline

Cas:328-93-8

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: 2,5-Bis(trifluoromethyl)aniline Synonyms: ALPHA,ALPHA,ALPHA,ALPHA',ALPHA',ALPHA'-HEXAFLUORO-2,5-XYLIDINE;2,5-DI(TRIFLUOROMETHYL)ANILINE;2,5-BIS(TRIFLUOROMETHYL)ANILINE;TIMTEC-BB SBB000691;2,5-BIS(TRIFLUOROMETHYL)AMILIN

2,5-Bis(trifluoromethyl)aniline 328-93-8 C8H5F6N

Cas:328-93-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

2,5-bis(trifluoromethyl)aniline/Manufacturer/High quality/Best price

Cas:328-93-8

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Synthetic route

1,4-Bis(trifluoromethyl)-2-nitro-benzene
320-88-7

1,4-Bis(trifluoromethyl)-2-nitro-benzene

2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

Conditions
ConditionsYield
With hydrogen; nickel In isopropyl alcohol at 70 - 90℃; under 3677.86 Torr; for 8h;73%
With hydrogenchloride; tin(ll) chloride
Stage #1: 1,4-Bis(trifluoromethyl)-2-nitro-benzene With hydrogenchloride; tin(II) chloride dihdyrate In methanol; water at 20 - 50℃;
Stage #2: With sodium hydroxide In water pH=10;
1,4-bis(trifluoromethyl)benzene
433-19-2

1,4-bis(trifluoromethyl)benzene

2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: disulfuric acid; sulfuric acid; nitric acid
2: SnCl2+2H2O; concentrated HCl
View Scheme
Multi-step reaction with 2 steps
1.1: nitric acid; sulfuric acid / 0 - 110 °C
2.1: hydrogenchloride; tin(II) chloride dihdyrate / water; methanol / 20 - 50 °C
2.2: pH 10
View Scheme
durch Nitrierung und Reduktion;
2-chloro 1,4-bis(trifluoromethyl)benzene
328-91-6

2-chloro 1,4-bis(trifluoromethyl)benzene

2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

Conditions
ConditionsYield
With ammonia; water at 200℃;
2-chloro-1,4-bis-(trichloromethyl)-benzene
10388-10-0

2-chloro-1,4-bis-(trichloromethyl)-benzene

2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: SbCl5; HF / 70 - 80 °C
2: water; ammonia / 200 °C
View Scheme
N-[3-(trifluoromethyl)phenyl]-2-pyridinecarboxamide
61350-01-4

N-[3-(trifluoromethyl)phenyl]-2-pyridinecarboxamide

2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper(I) bromide; dipotassium peroxodisulfate / acetonitrile / 12 h / 50 °C
2: hydrogenchloride / ethanol / 12 h / 100 °C
View Scheme
C14H8F6N2O

C14H8F6N2O

2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

Conditions
ConditionsYield
With hydrogenchloride In ethanol at 100℃; for 12h;
2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

salicylaldehyde
90-02-8

salicylaldehyde

(E)-2-(((2,5-bis(trifluoromethyl)phenyl)imino)methyl)phenol

(E)-2-(((2,5-bis(trifluoromethyl)phenyl)imino)methyl)phenol

Conditions
ConditionsYield
With formic acid In ethanol for 6h; Reflux;96%
2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

(S)-3-keto-4-aza-5α-androstane-1-ene-17β-formyl chloride

(S)-3-keto-4-aza-5α-androstane-1-ene-17β-formyl chloride

(5α,17β)-N-(2,5-bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide

(5α,17β)-N-(2,5-bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide

Conditions
ConditionsYield
With pyridine In toluene at 90℃; for 3h; Temperature;95.2%
2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

(5α,17β)-N-[2,5-bis(trifluoromethyl)-phenyl]-3-oxo-4-aza-5-androstane-17-carboxamide
164656-22-8

(5α,17β)-N-[2,5-bis(trifluoromethyl)-phenyl]-3-oxo-4-aza-5-androstane-17-carboxamide

Conditions
ConditionsYield
Stage #1: 3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester With boron tribromide In dichloromethane at 25℃; for 0.333333h;
Stage #2: 2,5-bis(trifluoromethyl)aniline In dichloromethane at 50℃;
93%
2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

androst-4-en-3-one-17β-carboxylic acid
302-97-6

androst-4-en-3-one-17β-carboxylic acid

N-(2',5'-Bistrifluoromethylphenyl)-3-oxo-androst-4-ene-17β-carboxamide
164656-19-3

N-(2',5'-Bistrifluoromethylphenyl)-3-oxo-androst-4-ene-17β-carboxamide

Conditions
ConditionsYield
Stage #1: 2,5-bis(trifluoromethyl)aniline With methylmagnesium chloride In tetrahydrofuran; toluene at 20℃; Large scale;
Stage #2: androst-4-en-3-one-17β-carboxylic acid With dmap; thionyl chloride; potassium carbonate In toluene at 20 - 30℃; for 3h; Large scale;
Stage #3: In tetrahydrofuran; toluene at 50 - 55℃; for 8h; Large scale;
90.14%
3-allyl-2-methylthio-6-trifluoromethyl-4(3H)-pyrimidinone
216016-30-7

3-allyl-2-methylthio-6-trifluoromethyl-4(3H)-pyrimidinone

2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

3-allyl-2-{2,5-bis(trifluoromethyl)phenyl}amino-6-trifluoromethyl-4(3H)pyrimidinone
216240-50-5

3-allyl-2-{2,5-bis(trifluoromethyl)phenyl}amino-6-trifluoromethyl-4(3H)pyrimidinone

Conditions
ConditionsYield
With ammonium chloride In N,N-dimethyl-formamide89%
2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

3-Oxo-4-aza-5α-androst-1-ene-17β-carboxylic acid
104239-97-6

3-Oxo-4-aza-5α-androst-1-ene-17β-carboxylic acid

dutasteride

dutasteride

Conditions
ConditionsYield
Stage #1: 2,5-bis(trifluoromethyl)aniline With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 105 - 110℃;
Stage #2: 3-Oxo-4-aza-5α-androst-1-ene-17β-carboxylic acid In N,N-dimethyl-formamide
88.21%
Stage #1: 3-Oxo-4-aza-5α-androst-1-ene-17β-carboxylic acid With pyridine; thionyl chloride In toluene at 0 - 18℃; for 4.66667h;
Stage #2: 2,5-bis(trifluoromethyl)aniline In toluene at 110℃; for 20h;
Stage #1: 3-Oxo-4-aza-5α-androst-1-ene-17β-carboxylic acid With pyridine; thionyl chloride In toluene at 0 - 18℃; for 5.6h;
Stage #2: 2,5-bis(trifluoromethyl)aniline; dmap In toluene at 110℃; for 20h; Product distribution / selectivity;
2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

acetophenone
98-86-2

acetophenone

(2,5-Bis-trifluoromethyl-phenyl)-[1-phenyl-eth-(E)-ylidene]-amine

(2,5-Bis-trifluoromethyl-phenyl)-[1-phenyl-eth-(E)-ylidene]-amine

Conditions
ConditionsYield
85%
2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

(4R,5S)-4-((2,5-bis(trifluoromethyl)phenyl)amino)-5-phenylcyclopent-2-enone

(4R,5S)-4-((2,5-bis(trifluoromethyl)phenyl)amino)-5-phenylcyclopent-2-enone

Conditions
ConditionsYield
Stage #1: 2,5-bis(trifluoromethyl)aniline With (S)-6,6’-bis(1-pyranyl)-1,1'-spirobiindane-7,7’-diyl hydrogenphosphate In 1,2-dichloro-ethane at 0℃; for 0.5h;
Stage #2: 2-furyl(phenyl)methanol In 1,2-dichloro-ethane at 20℃; for 22h;
83%
2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

C23H33NO4

C23H33NO4

dutasteride

dutasteride

Conditions
ConditionsYield
In tetrahydrofuran for 3h;82.2%
2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

C23H33NO4

C23H33NO4

dutasteride

dutasteride

Conditions
ConditionsYield
In dichloromethane at 20℃; for 3h;81.9%
2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

C21H29NO4

C21H29NO4

dutasteride

dutasteride

Conditions
ConditionsYield
In 1,4-dioxane at 20℃; for 6h;81.2%
2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

C22H31NO4

C22H31NO4

dutasteride

dutasteride

Conditions
ConditionsYield
With pyridine at 20℃; for 3h;80.5%
(5α,17β)-3-oxo-4-aza-5-androstane-17-(ethoxycarbonyl)-carboxylate
1416955-19-5

(5α,17β)-3-oxo-4-aza-5-androstane-17-(ethoxycarbonyl)-carboxylate

2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

(5α,17β)-N-[2,5-bis(trifluoromethyl)-phenyl]-3-oxo-4-aza-5-androstane-17-carboxamide
164656-22-8

(5α,17β)-N-[2,5-bis(trifluoromethyl)-phenyl]-3-oxo-4-aza-5-androstane-17-carboxamide

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In acetonitrile at -10 - -8℃; for 4h;80%
2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

methyl 3-oxo-4-aza-5α-androst-1-ene-17β-carboxylate
103335-41-7

methyl 3-oxo-4-aza-5α-androst-1-ene-17β-carboxylate

dutasteride

dutasteride

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In 2-methyltetrahydrofuran at 80℃; for 12h;78.23%
formaldehyd
50-00-0

formaldehyd

5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazole-2(3H)-thione

5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazole-2(3H)-thione

2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

3-(((2,5-bis(trifluoromethyl)phenyl)amino)methyl)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazole-2(3H)-thione

3-(((2,5-bis(trifluoromethyl)phenyl)amino)methyl)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazole-2(3H)-thione

Conditions
ConditionsYield
In ethanol at 20℃; for 3h;77%
2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

1-(2-fluoro-4-methoxyphenyl)-1-ethanone
74457-86-6

1-(2-fluoro-4-methoxyphenyl)-1-ethanone

N-[2-(dimethylamino)ethyl]-7-trifluoromethyl-2-[(2-fluoro-4-methoxy)phenyl]quinolin-4-amine

N-[2-(dimethylamino)ethyl]-7-trifluoromethyl-2-[(2-fluoro-4-methoxy)phenyl]quinolin-4-amine

Conditions
ConditionsYield
2,5-bis(trifluoromethyl)aniline; 1-(2-fluoro-4-methoxyphenyl)-1-ethanone With toluene-4-sulfonic acid In xylene Heating; Further stages.;75%
2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

cyanoacetic acid
372-09-8

cyanoacetic acid

N-[2,5-bis(trifluoromethyl)phenyl]cyanoacetamide
1140412-67-4

N-[2,5-bis(trifluoromethyl)phenyl]cyanoacetamide

Conditions
ConditionsYield
With diisopropyl-carbodiimide In N,N-dimethyl-formamide at 0 - 20℃; for 48h; Inert atmosphere;75%
Stage #1: 2,5-bis(trifluoromethyl)aniline; cyanoacetic acid In tetrahydrofuran at 0℃; Inert atmosphere;
Stage #2: With diisopropyl-carbodiimide In tetrahydrofuran at 20℃; for 24h; Inert atmosphere;
2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

1-(4-fluorophenyl)ethanone
403-42-9

1-(4-fluorophenyl)ethanone

N-[2-(dimethylamino)ethyl]-7-trifluoromethyl-2-[(4-fluoro)phenyl]quinolin-4-amine

N-[2-(dimethylamino)ethyl]-7-trifluoromethyl-2-[(4-fluoro)phenyl]quinolin-4-amine

Conditions
ConditionsYield
2,5-bis(trifluoromethyl)aniline; 1-(4-fluorophenyl)ethanone With toluene-4-sulfonic acid In xylene Heating; Further stages.;74%
2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

1-azido-2,5-bis(trifluoromethyl)benzene

1-azido-2,5-bis(trifluoromethyl)benzene

Conditions
ConditionsYield
Stage #1: 2,5-bis(trifluoromethyl)aniline With hydrogenchloride In water for 0.0833333h;
Stage #2: With sodium nitrite In water at 0℃; for 2h;
Stage #3: With sodium azide In water at 0 - 20℃; for 2h;
74%
(5α,17β)-3-oxo-4-azaandrost-1-ene-17-(ethoxycarbonyl)carboxylate
1416955-22-0

(5α,17β)-3-oxo-4-azaandrost-1-ene-17-(ethoxycarbonyl)carboxylate

2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

dutasteride

dutasteride

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In acetonitrile at -15 - -8℃; for 4h;73.8%
4-fluorobenzonitrile
1194-02-1

4-fluorobenzonitrile

2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

4,4'-(2,5-bis(trifluoromethyl)phenylazanediyl)dibenzonitrile

4,4'-(2,5-bis(trifluoromethyl)phenylazanediyl)dibenzonitrile

Conditions
ConditionsYield
With cesium fluoride In N,N-dimethyl-formamide at 165℃;73%
2'-Fluoroacetophenone
445-27-2

2'-Fluoroacetophenone

2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

N-<1-(2-fluorophenyl)ethylidene>-2,5-bis(trifluoromethyl)aniline
147218-04-0

N-<1-(2-fluorophenyl)ethylidene>-2,5-bis(trifluoromethyl)aniline

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 15h; Heating;70%
1-(4-trifluoromethylphenyl)ethanone
709-63-7

1-(4-trifluoromethylphenyl)ethanone

2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

2,5-bis(trifluoromethyl)-N-<1-<4-(trifluoromethyl)phenyl>ethylidene>aniline
147218-05-1

2,5-bis(trifluoromethyl)-N-<1-<4-(trifluoromethyl)phenyl>ethylidene>aniline

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 15h; Heating;69%
2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

1-(3-fluorophenyl)ethanone
455-36-7

1-(3-fluorophenyl)ethanone

N-[2-(dimethylamino)ethyl]-7-trifluoromethyl-2-[(3-fluoro)phenyl]quinolin-4-amine

N-[2-(dimethylamino)ethyl]-7-trifluoromethyl-2-[(3-fluoro)phenyl]quinolin-4-amine

Conditions
ConditionsYield
2,5-bis(trifluoromethyl)aniline; 1-(3-fluorophenyl)ethanone With toluene-4-sulfonic acid In xylene Heating; Further stages.;66%
1,1-Diphenylmethanol
91-01-0

1,1-Diphenylmethanol

2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

N-benzhydryl-2,5-bis(trifluoromethyl)aniline

N-benzhydryl-2,5-bis(trifluoromethyl)aniline

Conditions
ConditionsYield
With C15H25Cl2N3NiO3; potassium tert-butylate In octane at 140℃; for 12h; Schlenk technique;57%
2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

3-oxo-4-aza-5α-androstane-17β-carboxylic acid
103335-55-3

3-oxo-4-aza-5α-androstane-17β-carboxylic acid

(5α,17β)-N-[2,5-bis(trifluoromethyl)-phenyl]-3-oxo-4-aza-5-androstane-17-carboxamide
164656-22-8

(5α,17β)-N-[2,5-bis(trifluoromethyl)-phenyl]-3-oxo-4-aza-5-androstane-17-carboxamide

Conditions
ConditionsYield
Stage #1: 3-oxo-4-aza-5α-androstane-17β-carboxylic acid With pyridine; thionyl chloride In toluene at 2 - 20℃; for 2.5h;
Stage #2: 2,5-bis(trifluoromethyl)aniline In toluene at 20℃; for 192h;
56%
2-methylthio-3-propyl-6-trifluoromethyl-4(3H)-pyrimidinone
216240-56-1

2-methylthio-3-propyl-6-trifluoromethyl-4(3H)-pyrimidinone

2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

2-{2,5-bis(trifluoromethyl)phenyl}amino-3-propyl-6-trifluoromethyl-4(3H)-pyrimidinone
216240-34-5

2-{2,5-bis(trifluoromethyl)phenyl}amino-3-propyl-6-trifluoromethyl-4(3H)-pyrimidinone

Conditions
ConditionsYield
In N,N-dimethyl-formamide54.5%
NH-pyrazole
288-13-1

NH-pyrazole

2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

2-(tri(1H-pyrazol-1-yl)methyl)-5-(trifluoromethyl)aniline

2-(tri(1H-pyrazol-1-yl)methyl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
With potassium hydroxide In dimethyl sulfoxide for 1h; Reflux;53%
2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

6-Hydroxy-2-naphthoic acid
16712-64-4

6-Hydroxy-2-naphthoic acid

N-[2,5-bis(trifluoromethyl)phenyl]-6-hydroxynaphthalene-2-carboxamide

N-[2,5-bis(trifluoromethyl)phenyl]-6-hydroxynaphthalene-2-carboxamide

Conditions
ConditionsYield
With phosphorus trichloride In chlorobenzene at 130℃; for 0.666667h; Microwave irradiation;49%

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