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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

5-Hydroxy-1-methylpyrazole

Cas:33641-15-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price OLED 99% 33641-15-5 5-Hydroxy-1-methylpyrazole Manufacturer

Cas:33641-15-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

5-Hydroxy-1-methylpyrazole

Cas:33641-15-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent out in 24 hours after payment.Tracking number available 2) Secure and disc

5-Hydroxy-1-methylpyrazole CAS:33641-15-5

Cas:33641-15-5

Min.Order:1 Kilogram

FOB Price: $150.0 / 200.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--33641-15-5--High purity 5-Hydroxy-1-methylpyrazole factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established s

TIANFUCHEM--33641-15-5--High purity 5-Hydroxy-1-methylpyrazole factory price

Cas:33641-15-5

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 33641-15-5 with competitive price

Cas:33641-15-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

5-Hydroxy-1-methylpyrazole 33641-15-5

Cas:33641-15-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

5-Hydroxy-1-methylpyrazole CAS:33641-15-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organi

5-Hydroxy-1-methylpyrazole CAS:33641-15-5

Cas:33641-15-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

5-Hydroxy-1-methylpyrazole

Cas:33641-15-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

5-Hydroxy-1-methylpyrazole CAS 33641-15-5

Cas:33641-15-5

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

5-Hydroxy-1-methylpyrazole cas:33641-15-5

Cas:33641-15-5

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

5-Hydroxy-1-methylpyrazole

Cas:33641-15-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or yellowish white flaky crystal Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Sea/

5-Hydroxy-1-methylpyrazole

Cas:33641-15-5

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

5-HYDROXY-1-METHYL-1H-PYRAZOLE

Cas:33641-15-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

5-Hydroxy-1-methylpyrazole

Cas:33641-15-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

5-Hydroxy-1-methylpyrazole

Cas:33641-15-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

5-Hydroxy-1-methylpyrazole

Cas:33641-15-5

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

5-Hydroxy-1-methylpyrazole

Cas:33641-15-5

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

5-Hydroxy-1-methylpyrazole

Cas:33641-15-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

5-Hydroxy-1-methylpyrazole

Cas:33641-15-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Send Pharmaceutical Technology Co., Ltd.

stock,low price,high quality,high purity,good sevice Appearance:33641-15-5 Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:5g,10g,100g,1kg,5kg.... Application:R&D Transportation:by land,by ai

5-Hydroxy-1-methylpyrazole

Cas:33641-15-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in

SAGECHEM/ 5-Hydroxy-1-methylpyrazole /Manufacturer in China

Cas:33641-15-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

5-hydroxy-1-methylpyrazole

Cas:33641-15-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

5-Hydroxy-1-methylpyrazole

Cas:33641-15-5

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratoryAppearance:Off-white to light yellow crystal Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

5-Hydroxy-1-methylpyrazole cas no. 33641-15-5 96%

Cas:33641-15-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

5-Hydroxy-1-methylpyrazole

Cas:33641-15-5

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air

5-Hydroxy-1-methylpyrazole

Cas:33641-15-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

5-Hydroxy-1-methylpyrazole

Cas:33641-15-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

with high qualityAppearance:white powder Storage:Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Package:25kg/drum Application:as intermediates Transportation:by courier, air or sea Port:At any port from China

5-Hydroxy-1-methylpyrazole 33641-15-5 Pharmaceutical Intermediates

Cas:33641-15-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec 5-Hydroxy-1-methylpyrazole 100g

Cas:33641-15-5

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

1-methyl-5-hydroxypyrazol-4-carboxylic acid ethyl ester
88398-78-1

1-methyl-5-hydroxypyrazol-4-carboxylic acid ethyl ester

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

Conditions
ConditionsYield
Stage #1: 1-methyl-5-hydroxypyrazol-4-carboxylic acid ethyl ester With sodium hydroxide In water at 40℃; for 3h;
Stage #2: With hydrogenchloride for 3h; Reflux;
98%
at 120℃; for 6h; Temperature;
methyl 3-methoxyprop-2-enoate
34846-90-7

methyl 3-methoxyprop-2-enoate

methylhydrazine
60-34-4

methylhydrazine

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

Conditions
ConditionsYield
In methanol at 0℃; for 4.66667h; Heating / reflux;73%
In water at 10℃; Temperature;69.6%
In methanol for 8h; Reflux; Inert atmosphere;
In methanol; water for 2h; Cooling with ice;
aqueous monomethylhydrazine

aqueous monomethylhydrazine

β-isobutoxyacryl chloride
75945-54-9

β-isobutoxyacryl chloride

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

Conditions
ConditionsYield
With hydrogenchloride; triethylamine In tetrahydrofuran
methyl (2E)-3-methoxy-2-propenoate
5788-17-0

methyl (2E)-3-methoxy-2-propenoate

methylhydrazine
60-34-4

methylhydrazine

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

Conditions
ConditionsYield
In methanol at 90℃; for 12 - 18h;
methylhydrazine
60-34-4

methylhydrazine

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

Conditions
ConditionsYield
In methanol for 16h; Reflux; Inert atmosphere;
C6H8N2O3

C6H8N2O3

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

Conditions
ConditionsYield
With sulfuric acid at 65℃; for 8h; Temperature;18.6 g
1,4-dioxane
123-91-1

1,4-dioxane

3-(3-bromo-2-methyl-6-(methylsulfonyl)phenyl)-4,5-dihydroisoxazole
247922-29-8

3-(3-bromo-2-methyl-6-(methylsulfonyl)phenyl)-4,5-dihydroisoxazole

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

topramezone
210631-68-8

topramezone

Conditions
ConditionsYield
With carbon monoxide; potassium carbonate; triethylamine; triphenylphosphine; palladium(II) chloride In water100%
With hydrogenchloride; potassium carbonate; triethylamine; bis(triphenylphosphine)palladium(II) dichloride In water
4-methylsulphonyl-2-nitrobenzoyl chloride
110964-80-2

4-methylsulphonyl-2-nitrobenzoyl chloride

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

(1-methyl-5-hydroxypyrazol-4-yl)-(4-methanesulfonyl-2-nitrophenyl)methanone

(1-methyl-5-hydroxypyrazol-4-yl)-(4-methanesulfonyl-2-nitrophenyl)methanone

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane at 5 - 40℃; for 2h;96%
2-methyl-3-ethylsulfinyl-4-methylsulfonylbenzoic acid
1196958-18-5

2-methyl-3-ethylsulfinyl-4-methylsulfonylbenzoic acid

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

[3-(ethylsulfinyl)-2-methyl-4-(methylsulfonyl)phenyl](5-hydroxy-1-methyl-1H-pyrazol-4-yl)methanone
1196958-05-0

[3-(ethylsulfinyl)-2-methyl-4-(methylsulfonyl)phenyl](5-hydroxy-1-methyl-1H-pyrazol-4-yl)methanone

Conditions
ConditionsYield
With pyridine; thionyl chloride In ethyl acetate at -25 - 0℃; Inert atmosphere;91%
2-methyl-3-(methylsulfinyl)-4-(trifluoromethyl)benzoic acid
1070761-73-7

2-methyl-3-(methylsulfinyl)-4-(trifluoromethyl)benzoic acid

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

(5-hydroxy-1-methyl-1H-pyrazol-4-yl)[2-methyl-3-(methyl-sulfinyl)-4-(trifluoromethyl)phenyl]methanone
1070761-52-2

(5-hydroxy-1-methyl-1H-pyrazol-4-yl)[2-methyl-3-(methyl-sulfinyl)-4-(trifluoromethyl)phenyl]methanone

Conditions
ConditionsYield
With pyridine; thionyl chloride In ethyl acetate at -25 - 0℃; Inert atmosphere;90.7%
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

1-methyl-1H-pyrazol-5-yl tosylate

1-methyl-1H-pyrazol-5-yl tosylate

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; water at 0 - 20℃; for 2h; Green chemistry;88%
2-chloro-3-fluoro-4-trifluoromethylbenzoyl chloride

2-chloro-3-fluoro-4-trifluoromethylbenzoyl chloride

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

(2-chloro-3-fluoro-4-trifluoromethylphenyl)(5-hydroxy-1-methyl-1H-pyrazol-4-yl)methanone

(2-chloro-3-fluoro-4-trifluoromethylphenyl)(5-hydroxy-1-methyl-1H-pyrazol-4-yl)methanone

Conditions
ConditionsYield
With triethylamine In 1,2-dichloro-ethane at -5 - 20℃;86.9%
2-methoxy-3-methylsulfinyl-4-trifluoromethylbenzoic acid
1262652-20-9

2-methoxy-3-methylsulfinyl-4-trifluoromethylbenzoic acid

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

(5-hydroxy-1-methyl-1H-pyrazol-4-yl)[2-methoxy-3-(methylsulfinyl)-4-(trifluoromethyl)phenyl]methanone
1262671-11-3

(5-hydroxy-1-methyl-1H-pyrazol-4-yl)[2-methoxy-3-(methylsulfinyl)-4-(trifluoromethyl)phenyl]methanone

Conditions
ConditionsYield
With thionyl chloride; 3-Methylpyridine In ethyl acetate at -25 - -20℃; Product distribution / selectivity; Inert atmosphere;86.5%
2,4-dichlorobenzoyl chloride
89-75-8

2,4-dichlorobenzoyl chloride

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

1-methyl-5-(2,4-dichlorobenzoyloxy)-pyrazole
91436-74-7

1-methyl-5-(2,4-dichlorobenzoyloxy)-pyrazole

Conditions
ConditionsYield
With sodium hydroxide In chloroform86%
3-(3-bromo-2-methyl-6-(methylsulfonyl)phenyl)-4,5-dihydroisoxazole
247922-29-8

3-(3-bromo-2-methyl-6-(methylsulfonyl)phenyl)-4,5-dihydroisoxazole

formyl radical
2597-44-6

formyl radical

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

topramezone
210631-68-8

topramezone

Conditions
ConditionsYield
Stage #1: 3-(3-bromo-2-methyl-6-(methylsulfonyl)phenyl)-4,5-dihydroisoxazole With potassium carbonate In 1,4-dioxane Reflux;
Stage #2: 1-methyl-5-hydroxypyrazole With triphenylphosphine; sodium iodide In 1,4-dioxane at 60℃; for 0.5h;
Stage #3: formyl radical With palladium on activated charcoal In 1,4-dioxane at 120℃; under 11251.1 Torr; for 20h; Reagent/catalyst; Temperature;
84.4%
3-(4,5-dihydroisoxazol-3-yl)-4-methylsulfonyl-2-methylbenzoic acid
223646-24-0

3-(4,5-dihydroisoxazol-3-yl)-4-methylsulfonyl-2-methylbenzoic acid

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

topramezone
210631-68-8

topramezone

Conditions
ConditionsYield
Stage #1: 3-(4,5-dihydroisoxazol-3-yl)-4-methylsulfonyl-2-methylbenzoic acid With pyridine; thionyl chloride In benzene for 3h; Reflux;
Stage #2: 1-methyl-5-hydroxypyrazole With triethylamine In 1,4-dioxane at 20℃; for 3h;
Stage #3: With potassium carbonate for 6h; Reflux;
81.46%
Stage #1: 3-(4,5-dihydroisoxazol-3-yl)-4-methylsulfonyl-2-methylbenzoic acid With pyridine; thionyl chloride In toluene for 3h; Reflux;
Stage #2: 1-methyl-5-hydroxypyrazole With triethylamine In 1,4-dioxane at 20℃; for 3h;
80.5%
Stage #1: 3-(4,5-dihydroisoxazol-3-yl)-4-methylsulfonyl-2-methylbenzoic acid With thionyl chloride for 2h; Reflux;
Stage #2: With triethylamine In 1,2-dichloro-ethane at 20 - 30℃; for 0.5h;
Stage #3: 1-methyl-5-hydroxypyrazole In 1,2-dichloro-ethane for 4h; Reflux;
20.87%
pentafluorobenzenesulonyl chloride
832-53-1

pentafluorobenzenesulonyl chloride

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

1-methyl-1H-pyrazol-5-yl 2,3,4,5,6-pentafluorobenzenesulfonate

1-methyl-1H-pyrazol-5-yl 2,3,4,5,6-pentafluorobenzenesulfonate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;81%
3-(3-bromo-2-methyl-6-(methylsulfonyl)phenyl)-4,5-dihydroisoxazole
247922-29-8

3-(3-bromo-2-methyl-6-(methylsulfonyl)phenyl)-4,5-dihydroisoxazole

carbon monoxide
201230-82-2

carbon monoxide

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

[3-(4,5-dihydro-1,2-oxazol-3-yl)-4-mesyl-o-tolyl](5-hydroxy-1-methylpyrazol-4-yl)methanone

[3-(4,5-dihydro-1,2-oxazol-3-yl)-4-mesyl-o-tolyl](5-hydroxy-1-methylpyrazol-4-yl)methanone

Conditions
ConditionsYield
With potassium carbonate; triethylamine; triphenylphosphine; palladium dichloride In 1,4-dioxane at 120℃; under 4125.41 - 4875.49 Torr; for 40h; Autoclave;81%
C18H16N2O5

C18H16N2O5

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

C22H20N4O5

C22H20N4O5

Conditions
ConditionsYield
Stage #1: C18H16N2O5 With thionyl chloride In tetrahydrofuran at 20 - 80℃; for 1.5h;
Stage #2: 1-methyl-5-hydroxypyrazole With triethylamine In dichloromethane for 0.5h;
80%
N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

5-chloro-1-methyl-1H-pyrazole-4-carbaldehyde
117007-77-9

5-chloro-1-methyl-1H-pyrazole-4-carbaldehyde

Conditions
ConditionsYield
Stage #1: N,N-dimethyl-formamide; 1-methyl-5-hydroxypyrazole With trichlorophosphate at 80℃; for 6.16667h;
Stage #2: With sodium hydrogencarbonate In water
77%
With trichlorophosphate In methanol at 0 - 80℃; for 7h; Inert atmosphere;12.87 g
With trichlorophosphate at 0 - 80℃; for 12h; Inert atmosphere;16.31 g
3-(4,5-dihydroisoxazol-3-yl)-4-methylsulfonyl-2-methylbenzoic acid
223646-24-0

3-(4,5-dihydroisoxazol-3-yl)-4-methylsulfonyl-2-methylbenzoic acid

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

[3-(4,5-dihydro-1,2-oxazol-3-yl)-4-mesyl-o-tolyl](5-hydroxy-1-methylpyrazol-4-yl)methanone

[3-(4,5-dihydro-1,2-oxazol-3-yl)-4-mesyl-o-tolyl](5-hydroxy-1-methylpyrazol-4-yl)methanone

Conditions
ConditionsYield
Stage #1: 3-(4,5-dihydroisoxazol-3-yl)-4-methylsulfonyl-2-methylbenzoic acid With thionyl chloride for 3h; Reflux;
Stage #2: 1-methyl-5-hydroxypyrazole With triethylamine In tetrahydrofuran at 20℃; for 3h;
Stage #3: With potassium carbonate In tetrahydrofuran for 2h; Reflux;
76.2%
methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

1-methylpyrazole-5-yl methanesulfonate

1-methylpyrazole-5-yl methanesulfonate

Conditions
ConditionsYield
With triethylamine In ethyl acetate at 0 - 20℃; for 0.166667h; Green chemistry;74%
With triethylamine In tetrahydrofuran at 0℃; for 2h;7.04 g
trimethoxonium tetrafluoroborate
420-37-1

trimethoxonium tetrafluoroborate

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

1,2-dimethyl-1,2-dihydropyrazol-3-on
3514-11-2

1,2-dimethyl-1,2-dihydropyrazol-3-on

Conditions
ConditionsYield
In nitromethane at 20℃; for 24h;71%
p-methoxybenzyl chloride
824-94-2

p-methoxybenzyl chloride

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

A

1-(4-Methoxy-benzyl)-2-methyl-1,2-dihydro-pyrazol-3-one

1-(4-Methoxy-benzyl)-2-methyl-1,2-dihydro-pyrazol-3-one

B

5-(4-Methoxy-benzyloxy)-1-methyl-1H-pyrazole

5-(4-Methoxy-benzyloxy)-1-methyl-1H-pyrazole

Conditions
ConditionsYield
In methanol at 20℃; for 24h;A 70%
B 5%
9-methoxy-6-chloroformyl-3a,4-dihydro-3H-chromeno[4,3-c]isoxazoline
293312-46-6

9-methoxy-6-chloroformyl-3a,4-dihydro-3H-chromeno[4,3-c]isoxazoline

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

(5-hydroxy-1-methyl-1H-pyrazol-4-yl)-(9-methoxy-3a,4-dihydro-3H-chromeno[4,3-c]isoxazolin-6-yl)methanone
293312-16-0

(5-hydroxy-1-methyl-1H-pyrazol-4-yl)-(9-methoxy-3a,4-dihydro-3H-chromeno[4,3-c]isoxazolin-6-yl)methanone

Conditions
ConditionsYield
Stage #1: 9-methoxy-6-chloroformyl-3a,4-dihydro-3H-chromeno[4,3-c]isoxazoline; 1-methyl-5-hydroxypyrazole With trimethylamine In acetonitrile at 0 - 20℃;
Stage #2: With potassium carbonate In 1,4-dioxane for 7h; Heating / reflux;
68%
1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

benzyl alcohol
100-51-6

benzyl alcohol

5-(benzyloxy)-1-methyl-1H-pyrazole

5-(benzyloxy)-1-methyl-1H-pyrazole

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at -60 - -30℃; for 19h;66%
3-(2-fluoro-4-methylphenyl)-2-methyl-4-oxo-3,4-dihydroquinazoline-6-carboxylic acid

3-(2-fluoro-4-methylphenyl)-2-methyl-4-oxo-3,4-dihydroquinazoline-6-carboxylic acid

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

1-methyl-1H-pyrazol-5-yl 3-(2-fluoro-4-methylphenyl)-2-methyl-4-oxo-3,4-dihydroquinazoline-6-carboxylate

1-methyl-1H-pyrazol-5-yl 3-(2-fluoro-4-methylphenyl)-2-methyl-4-oxo-3,4-dihydroquinazoline-6-carboxylate

Conditions
ConditionsYield
Stage #1: 3-(2-fluoro-4-methylphenyl)-2-methyl-4-oxo-3,4-dihydroquinazoline-6-carboxylic acid With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 1h;
Stage #2: 1-methyl-5-hydroxypyrazole With dmap In dichloromethane at 20℃;
65%
(2-trimethylethylsilylethoxy)methyl chloride
76513-69-4

(2-trimethylethylsilylethoxy)methyl chloride

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

2-methyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1,2-dihydro-3H-pyrazol-3-one

2-methyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1,2-dihydro-3H-pyrazol-3-one

Conditions
ConditionsYield
Stage #1: 1-methyl-5-hydroxypyrazole With potassium carbonate In acetonitrile at 20℃; for 0.5h;
Stage #2: (2-trimethylethylsilylethoxy)methyl chloride In acetonitrile at 20℃; for 14h;
63%
With potassium carbonate In acetonitrile at 20℃; for 16h;10 g
2-chloro-6-methyl-isonicotinic acid methyl ester
3998-90-1

2-chloro-6-methyl-isonicotinic acid methyl ester

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

methyl 2-(5-hydroxy-1-methyl-1H-pyrazol-4-yl)-6-methylisonicotinate hydrochloride

methyl 2-(5-hydroxy-1-methyl-1H-pyrazol-4-yl)-6-methylisonicotinate hydrochloride

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate at 130℃; for 16h; Inert atmosphere;61%
3-(4-chloro-2-methylphenyl)-2-methyl-4-oxo-3,4-dihydroquinazoline-6-carboxylic acid

3-(4-chloro-2-methylphenyl)-2-methyl-4-oxo-3,4-dihydroquinazoline-6-carboxylic acid

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

1-methyl-1H-pyrazol-5-yl 3-(4-chloro-2-methylphenyl)-2-methyl-4-oxo-3,4-dihydroquinazoline-6-carboxylate

1-methyl-1H-pyrazol-5-yl 3-(4-chloro-2-methylphenyl)-2-methyl-4-oxo-3,4-dihydroquinazoline-6-carboxylate

Conditions
ConditionsYield
Stage #1: 3-(4-chloro-2-methylphenyl)-2-methyl-4-oxo-3,4-dihydroquinazoline-6-carboxylic acid With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 1h;
Stage #2: 1-methyl-5-hydroxypyrazole With dmap In dichloromethane at 20℃;
60%
6-amino-5-chloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-pyrimidine-4-carboxylic acid

6-amino-5-chloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-pyrimidine-4-carboxylic acid

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

C16H12Cl2FN5O3

C16H12Cl2FN5O3

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine In dichloromethane at 25℃; for 4h;59%
2-chloro-4-methoxy-3-(1-oxothianylideneamino)benzoic acid
1207343-99-4

2-chloro-4-methoxy-3-(1-oxothianylideneamino)benzoic acid

2-hydroxy-2-methylpropanenitrile
75-86-5

2-hydroxy-2-methylpropanenitrile

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

2-chloro-1-[(5-hydroxy-1-methylpyrazole-4-yl)carbonyl]-4-methoxy-3-(1-oxothianylideneamino)benzene
1207341-28-3

2-chloro-1-[(5-hydroxy-1-methylpyrazole-4-yl)carbonyl]-4-methoxy-3-(1-oxothianylideneamino)benzene

Conditions
ConditionsYield
Stage #1: 2-chloro-4-methoxy-3-(1-oxothianylideneamino)benzoic acid With 1,1'-carbonyldiimidazole In chloroform at 20℃; for 1h;
Stage #2: 1-methyl-5-hydroxypyrazole With triethylamine In chloroform for 1h; Reflux;
Stage #3: 2-hydroxy-2-methylpropanenitrile With triethylamine In acetonitrile at 20℃;
55%
3-(4-chlorophenyl)-2-methyl-4-oxo-3,4-dihydroquinazoline-6-carboxylic acid

3-(4-chlorophenyl)-2-methyl-4-oxo-3,4-dihydroquinazoline-6-carboxylic acid

1-methyl-5-hydroxypyrazole
33641-15-5

1-methyl-5-hydroxypyrazole

1-methyl-1H-pyrazol-5-yl 3-(4-chlorophenyl)-2-methyl-4-oxo-3,4-dihydroquinazoline-6-carboxylate

1-methyl-1H-pyrazol-5-yl 3-(4-chlorophenyl)-2-methyl-4-oxo-3,4-dihydroquinazoline-6-carboxylate

Conditions
ConditionsYield
Stage #1: 3-(4-chlorophenyl)-2-methyl-4-oxo-3,4-dihydroquinazoline-6-carboxylic acid With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 1h;
Stage #2: 1-methyl-5-hydroxypyrazole With dmap In dichloromethane at 20℃;
53%

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