CAS No.75-86-5,2-Hydroxy-2-methylpropanenitrile Suppliers

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Synthetic route

: potassium cyanide

: 67-64-1
acetone

: 75-86-5
2-hydroxy-2-methylpropanenitrile

Conditions

Conditions	Yield
With acetic acid In water at 30℃; Microreactor technology; Continuous flow system;	99%
With sodium metabisulfite In water at 20℃; for 0.5h;
Stage #1: acetone With sodium hydrogen sulfite In water at 0℃; for 1h; Stage #2: potassium cyanide In water for 14h;

: 74-90-8
hydrogen cyanide

: 67-64-1
acetone

: 75-86-5
2-hydroxy-2-methylpropanenitrile

Conditions

Conditions	Yield
With sodium hydroxide; sulfuric acid; sodium cyanide In water at 10℃; for 1.5h; pH=7.3;	95%
With pyridine
With quinoline

: 19355-69-2
2-amino-2-cyanopropane

A: 18992-13-7
2-cyano-2-nitropropane

B: 40561-27-1
1-cyano-1-methylethylnitrate

C: 58102-56-0
tris-(1-cyano-1-methyl-ethyl)-hydroxylamine

D: 75-86-5
2-hydroxy-2-methylpropanenitrile

Conditions

Conditions	Yield
With perchloric acid; sodium nitrite at 25℃; Product distribution; var. α-aminonitriles; other conditions, also radical scavengers;	A 47.4% B 0.4% C 13.9% D 37.3%

...Expand

: 773837-37-9
sodium cyanide

: 67-64-1
acetone

: 75-86-5
2-hydroxy-2-methylpropanenitrile

Conditions

Conditions	Yield
With sulfuric acid In water at 20℃;	29%

: 74-90-8
hydrogen cyanide

: 75-86-5
2-hydroxy-2-methylpropanenitrile

Conditions

Conditions	Yield
With aluminum oxide at 150 - 300℃; Beim Leiten von Aceton-Dampf im den Gemisch;
With dipotassium hydrogenphosphate; kieselguhr at 60℃; Beim Leiten von Aceton-Dampf im den Gemisch;

: 151-50-8
potassium cyanide

: 540-92-1
acetone sodium bisulfite

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 67-56-1
methanol

: 74-90-8
hydrogen cyanide

: 67-64-1
acetone

: 75-86-5
2-hydroxy-2-methylpropanenitrile

Conditions

Conditions	Yield
at 20℃; Kinetics; Verlauf der Reaktion; auch in anderen Loesungsmitteln;
at 20℃; Rate constant; und in anderen Loesungsmitteln;

...Expand

: 60-29-7
diethyl ether

: 74-90-8
hydrogen cyanide

: 67-64-1
acetone

: 75-86-5
2-hydroxy-2-methylpropanenitrile

...Expand

: 74-90-8
hydrogen cyanide

: 143-33-9
sodium cyanide

: 67-64-1
acetone

: 75-86-5
2-hydroxy-2-methylpropanenitrile

...Expand

: 74-90-8
hydrogen cyanide

: 151-50-8
potassium cyanide

: 67-64-1
acetone

: 75-86-5
2-hydroxy-2-methylpropanenitrile

...Expand

: 143-33-9
sodium cyanide

: 67-64-1
acetone

: 75-86-5
2-hydroxy-2-methylpropanenitrile

Conditions

Conditions	Yield
With sulfur dioxide; water
With sulfuric acid
With ammonium chloride In diethyl ether; water at 0 - 10℃; for 1h;
With sulfuric acid at 10 - 15℃;

: 151-50-8
potassium cyanide

: 67-64-1
acetone

: 75-86-5
2-hydroxy-2-methylpropanenitrile

Conditions

Conditions	Yield
With methanol; sulfuric acid
Stage #1: acetone With sodium hydrogensulfite In water at 0℃; for 2h; Stage #2: potassium cyanide In water at 20℃;

: 67-64-1
acetone

: 75-86-5
2-hydroxy-2-methylpropanenitrile

Conditions

Conditions	Yield
With sodium disulfite man gibt nach dem Erkalten eine gesaettigte waessr.Kaliumcyanidloesung hinzu;

: 74-90-8
hydrogen cyanide

: 7732-18-5
water

: 67-64-1
acetone

: 75-86-5
2-hydroxy-2-methylpropanenitrile

Conditions

Conditions	Yield
at 20℃; Kinetics; Verlauf der Reaktion;

...Expand

: 67-64-1
acetone

alkali cyanide: alkali cyanide

: 75-86-5
2-hydroxy-2-methylpropanenitrile

Conditions

Conditions	Yield
With sodium hydrogensulfite

: 74-90-8
hydrogen cyanide

: 67-64-1
acetone

calcium cyanide: calcium cyanide

: 75-86-5
2-hydroxy-2-methylpropanenitrile

...Expand

: 74-90-8
hydrogen cyanide

: 67-64-1
acetone

copper (I)-cyanide: copper (I)-cyanide

: 75-86-5
2-hydroxy-2-methylpropanenitrile

...Expand

: 74-90-8
hydrogen cyanide

: 67-64-1
acetone

K2CO3: K2CO3

: 75-86-5
2-hydroxy-2-methylpropanenitrile

...Expand

: 74-90-8
hydrogen cyanide

: 67-64-1
acetone

KOH: KOH

: 75-86-5
2-hydroxy-2-methylpropanenitrile

...Expand

: 7677-24-9
trimethylsilyl cyanide

: 67-64-1
acetone

: 75-86-5
2-hydroxy-2-methylpropanenitrile

Conditions

Conditions	Yield
Stage #1: trimethylsilyl cyanide; acetone With zinc(II) iodide Addition; Stage #2: With hydrogenchloride Substitution;

: 532-28-5, 613-88-7
(RS)-mandelonitrile

: 67-64-1
acetone

A: 100-52-7
benzaldehyde

B: 75-86-5
2-hydroxy-2-methylpropanenitrile

Conditions

Conditions	Yield
With Amberlite IRA904 OH(1-) In toluene at 25℃; for 5h; Equilibrium constant;

...Expand

: trifluoro-methanesulfonic acid cyano-dimethyl-methyl ester

A: 75-86-5
2-hydroxy-2-methylpropanenitrile

B: 126-98-7
methacrylonitrile

Conditions

Conditions	Yield
In dimethylsulfoxide-d6; chloroform-d1 at 25℃; Kinetics; Product distribution; Further Variations:; Solvents;	A n/a B 53 % Spectr.

: methacrylamide sulphate

: 75-86-5
2-hydroxy-2-methylpropanenitrile

Conditions

Conditions	Yield
In water

: 773837-37-9
sodium cyanide

: 3483-11-2
lithium acetoacetate

A: 89417-57-2
2-Hydroxy-2-methyl-bernsteinsaeuremonoamid

B: 75-86-5
2-hydroxy-2-methylpropanenitrile

C: 67-64-1
acetone

Conditions

Conditions	Yield
With hydrogenchloride In water at 0 - 20℃; for 48h; pH=4.5;

...Expand

: 108-94-1
cyclohexanone

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 931-97-5
1-hydroxy-1-cyclohexanecarbonitrile

Conditions

Conditions	Yield
With Hevea brasiliensis (S)-hydroxynitrile lyase pH=4.5; aq. buffer; Enzymatic reaction;	100%
With titanium(IV) isopropylate; dl-3-(2-hydroxy-1-naphthylidene)-imino-ε-caprolactam (Nap-ACL) In dichloromethane for 3h; Ambient temperature;	99%
With ytterbium(III) isopropoxide In tetrahydrofuran for 0.5h; Ambient temperature;	94%

: 122-78-1
phenylacetaldehyde

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 50353-47-4
phenyl acetaldehyde cyanohydrin

Conditions

Conditions	Yield
With potassium carbonate In ethanol for 2h; Ambient temperature;	100%

: 110-62-3
pentanal

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 10021-65-5
D-2-Hydroxy-hexansaeurenitril

Conditions

Conditions	Yield
With citrate buffer In di-isopropyl ether for 13h; Ambient temperature; mandelonitrile lyase, pH 5.5;	100%
oxynitrilase;	82%

: 112-44-7
undecylaldehyde

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 130273-76-6
(RS)-2-hydroxy-dodecanenitrile

Conditions

Conditions	Yield
With titanium(IV) isopropylate for 21h; Ambient temperature;	100%
With triethylamine for 1.5h; Ambient temperature;	99%

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 1885-14-9
phenyl chloroformate

: 130312-20-8
1-cyano-1-methyl-ethylphenylcarbonate

Conditions

Conditions	Yield
With pyridine for 0.5h;	100%

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 2043-61-0
cyclohexanecarbaldehyde

: 100007-62-3, 107485-34-7, 4354-47-6
2-cyclohexyl-2-hydroxyacetonitrile

Conditions

Conditions	Yield
With titanium(IV) isopropylate for 44h; Ambient temperature;	100%
With titanium(IV) isopropylate; dl-3-(2-hydroxy-1-naphthylidene)-imino-ε-caprolactam (Nap-ACL) In dichloromethane for 2.5h; Ambient temperature;	99%
With ytterbium(III) isopropoxide In tetrahydrofuran for 0.5h; Ambient temperature;	86%

: 66086-70-2
3-(4-nitro-phenyl)-6-phenyl-[1,2,4]triazine 4-oxide

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 3-(4-nitro-phenyl)-6-phenyl-[1,2,4]triazine-5-carbonitrile

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 0.333333h; Heating;	100%

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 3,6-bis-(4-chloro-phenyl)-[1,2,4]triazine 4-oxide

: 3,6-bis-(4-chloro-phenyl)-[1,2,4]triazine-5-carbonitrile

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 0.333333h; Heating;	100%

: 2627-86-3
(S)-1-phenyl-ethylamine

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 882182-35-6
2-methyl-2-(((1S)-1-phenylethyl)amino)propanenitrile

Conditions

Conditions	Yield
In methanol at 20℃; for 24h;	100%
In methanol at 20℃; for 10h;	47%

: 104062-70-6
(1-formyl-pentyl)-carbamic acid tert-butyl ester

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 180779-12-8
[1-(cyano-hydroxy-methyl)-pentyl]-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 20h;	100%
With triethylamine In dichloromethane at 20℃;

: 1079-66-9
chloro-diphenylphosphine

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 2-[(diphenylphosphino)oxy]-2-methylpropionitrile

Conditions

Conditions	Yield
With dmap; triethylamine In tetrahydrofuran at 20℃; for 2h;	100%

: 63-05-8
Androstenedione

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 77881-13-1
17β-cyano-17α-hydroxy-4-androsten-3-one

Conditions

Conditions	Yield
With sodium carbonate In methanol; water at 17 - 40℃; for 29h; pH=8 - 9;	100%
With water; sodium carbonate In methanol at 38 - 42℃; for 4h; pH=8 - 9;	100%
With methanol; potassium hydroxide at 50℃; for 6h; Autoclave; Large scale;	95.9%

: 1134620-82-8
(2S)-(7-methyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)propanal

: 75-86-5
2-hydroxy-2-methylpropanenitrile

C12H17N3O: C12H17N3O

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; Inert atmosphere;	100%

2-hydroxy-2-methylpropanenitrile: 2-hydroxy-2-methylpropanenitrile

: 31007-06-4
2-(4-methoxyphenyl)propionitrile

Conditions

Conditions	Yield
With 3-[bis-(4-methoxy-phenyl)-phosphanyl]-2H-isoquinolin-1-one; N-{6-[bis-(4-methoxy-phenyl)-phosphanyl]-pyridin-2-yl}-2,2-dimethyl-propionamide; bis(1,5-cyclooctadiene)nickel (0) In toluene at 35℃; for 25h; Inert atmosphere; regioselective reaction;	100%

: 622-97-9
1-ethenyl-4-methylbenzene

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 75920-45-5
(+/-)-2-(4'-methylphenyl)-propionitrile

Conditions

Conditions	Yield
With 3-[bis-(4-methoxy-phenyl)-phosphanyl]-2H-isoquinolin-1-one; N-{6-[bis-(4-methoxy-phenyl)-phosphanyl]-pyridin-2-yl}-2,2-dimethyl-propionamide; bis(1,5-cyclooctadiene)nickel (0) In toluene at 35℃; for 25h; Inert atmosphere; regioselective reaction;	100%

: 405-99-2
para-fluorostyrene

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 51965-61-8
4-fluoro-α-methylbenzeneacetonitrile

Conditions

Conditions	Yield
With 3-[bis-(4-methoxy-phenyl)-phosphanyl]-2H-isoquinolin-1-one; N-{6-[bis-(4-methoxy-phenyl)-phosphanyl]-pyridin-2-yl}-2,2-dimethyl-propionamide; bis(1,5-cyclooctadiene)nickel (0) In toluene at 35℃; for 25h; Inert atmosphere; regioselective reaction;	100%

: 2628-16-2
p-acetoxystyrene

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 1132795-53-9
2-(4-acetoxyphenyl)propanenitrile

Conditions

Conditions	Yield
With 3-[bis-(4-methoxy-phenyl)-phosphanyl]-2H-isoquinolin-1-one; N-{6-[bis-(4-methoxy-phenyl)-phosphanyl]-pyridin-2-yl}-2,2-dimethyl-propionamide; bis(1,5-cyclooctadiene)nickel (0) In toluene at 35℃; for 40h; Inert atmosphere; regioselective reaction;	100%

p-vinylbiphenyl: p-vinylbiphenyl

: 75-86-5
2-hydroxy-2-methylpropanenitrile

Conditions

Conditions	Yield
With 3-[bis-(4-methoxy-phenyl)-phosphanyl]-2H-isoquinolin-1-one; N-{6-[bis-(4-methoxy-phenyl)-phosphanyl]-pyridin-2-yl}-2,2-dimethyl-propionamide; bis(1,5-cyclooctadiene)nickel (0) In toluene at 35℃; for 25h; Inert atmosphere; regioselective reaction;	100%

Conditions

Conditions	Yield
With 3-[bis-(4-methoxy-phenyl)-phosphanyl]-2H-isoquinolin-1-one; N-{6-[bis-(4-methoxy-phenyl)-phosphanyl]-pyridin-2-yl}-2,2-dimethyl-propionamide; bis(1,5-cyclooctadiene)nickel (0) In toluene at 35℃; for 25h; Inert atmosphere; regioselective reaction;	100%

2-hydroxy-2-methylpropanenitrile: 2-hydroxy-2-methylpropanenitrile

: 35666-81-0
2-methyl-2-(morpholin-4-yl)propanenitrile

Conditions

Conditions	Yield
In acetone at 20℃; for 24h;	100%
In acetone at 20℃; for 24h;	100%
at 100℃; for 1h;	76%

: 105499-11-4
2-(Boc-amino)propionaldehyde

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 103865-01-6
C9H16N2O3

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 20h;	100%

: 123285-52-9
2-(S)-[N-(tert-butoxycarbonyl)amino]-3-methylbutanal

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 163218-15-3
C11H20N2O3

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 20h;	100%

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 346690-97-9
N-(tert-butoxycarbonyl)-2-aminobutanal

: 166196-01-6
tert-butyl (1-cyano-1-hydroxybutan-2-yl)carbamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 20h;	100%

: 1256750-19-2
tert-butyl (1,1-dideutero-3-oxo-1-(perdeuterocyclobutyl)propan-2-yl)carbamate

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 1256750-20-5
tert-butyl (1,1-dideutero-3-cyano-3-hydroxy-1-(perdeuterocyclobutyl)propan-2-yl)carbamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 15h;	100%

: 2-(2-cyclopropylidenevinyl)naphthalene

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: (E)-1-(2-(naphthalen-2-yl)vinyl)cyclopropanecarbonitrile

Conditions

Conditions	Yield
With triphenyl phosphite; tetrakis(triphenylphosphite)nickel(0) In toluene at 100℃; for 1h;	100%

: 498-66-8
norborn-2-ene

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 2234-26-6
2-norbornanecarbonitrile

Conditions

Conditions	Yield
With nickel(II) acetate tetrahydrate; triphenylphosphine; zinc In N,N-dimethyl-formamide at 90℃; for 15h; Reagent/catalyst; Solvent; Autoclave;	100%
With nickel(II) chloride hexahydrate; 1,3-bis-(diphenylphosphino)propane; zinc In N,N-dimethyl-formamide at 90℃; under 3750.38 Torr; for 15h; Catalytic behavior; Reagent/catalyst; Solvent; Autoclave; Inert atmosphere;	94%

: 2-(2-cyclopropylidenevinyl)naphthalene

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: C16H13N

Conditions

Conditions	Yield
With tetrakis(triphenylphosphite)nickel(0); phosphorous acid trimethyl ester In toluene at 100℃; for 1h; stereoselective reaction;	100%

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 19355-69-2
2-amino-2-cyanopropane

: 34241-39-9
azobisisobutyronitrile

Conditions

Conditions	Yield
	99.8%

: manganese(II) sulfate

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 13027-88-8
2-hydroxyisobutyramide

Conditions

Conditions	Yield
With potassium permanganate; manganese dioxide; sulfuric acid In water; acetone	99.5%

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 594-61-6
2-methyllactic acid

Conditions

Conditions	Yield
Stage #1: 2-hydroxy-2-methylpropanenitrile With sulfuric acid; water; 1-Nitropropane at 40 - 55℃; for 0.5h; Stage #2: With water; 1-Nitropropane at 130℃; for 1h; Product distribution / selectivity;	99.2%
Stage #1: 2-hydroxy-2-methylpropanenitrile With nitromethane; sulfuric acid; water at 40 - 55℃; for 0.25 - 0.5h; Stage #2: With nitromethane; water at 120 - 130℃; for 0.5 - 1h; Product distribution / selectivity;	98%
Stage #1: 2-hydroxy-2-methylpropanenitrile With Nitroethane; sulfuric acid; water at 40 - 55℃; for 0.333333h; Stage #2: With Nitroethane; water at 120 - 130℃; for 0.75 - 1h; Product distribution / selectivity;	98%

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