bulk production goods in stock Chemsigma International Co.,Ltd. is a chemical manufacturer, specialize in custom synthesis and organic chemical manufacturing for overseas customers, in the field of API, pharmaceutical intermediates, chemical i
Cas:36082-50-5
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiry1. High quality: 99%up 2. Big capacity: 50mt per month 3. A lower price with high quality 4. Certificate: GMP, COA 5. Package: Packed with multi-layer paper bags, with polyethylene inner bag, net weight 25kg per bag. 6. Storage should be stored
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:36082-50-5
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/60.html Product Name 5-Bromo-2,4-dichloropyrimidine CAS No. 36082-50-5
Cas:36082-50-5
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inquiryOur company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o
Cas:36082-50-5
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inquiryOur advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity ≥99% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The packag
Cas:36082-50-5
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:36082-50-5
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inquiryName 5-Bromo-2,4-dichloropyrimidine Synonyms 2,4-Dichloro-5-bromo pyrimidine CAS NO. 36082-50-5 Molecular Formula C4HBrCl2N2
Cas:36082-50-5
Min.Order:5 Metric Ton
FOB Price: $1.0 / 2.0
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:light yellow solid or liquid Storage:Store in sealed contai
Cas:36082-50-5
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:36082-50-5
Min.Order:1 Kilogram
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inquiryProduct Name: 5-Bromo-2,4-dichloropyrimidine Synonyms: BUTTPARK 48\06-22;5-BROMO-2,4-DICHLOROPYRIMIDINE;TIMTEC-BB SBB003301;5-Bromo-2,4-Dichloropyridimidine;5-BROMO-2,4-DICHLOROPYRIMIDINE 99%;2,4-DICHLORO-5-BROMO PYRIMIDINE;5-Bromo-2,4-dichL;5-
Cas:36082-50-5
Min.Order:1 Gram
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inquiry5-Bromo-2,4-dichloropyrimidine CAS:36082-50-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality or
Cas:36082-50-5
Min.Order:1 Gram
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:36082-50-5
Min.Order:1 Kilogram
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h
Cas:36082-50-5
Min.Order:100 Metric Ton
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inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensu
Cas:36082-50-5
Min.Order:1 Kilogram
FOB Price: $40.0 / 50.0
Type:Lab/Research institutions
inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:36082-50-5
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:36082-50-5
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:36082-50-5
Min.Order:1 Gram
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:36082-50-5
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:36082-50-5
Min.Order:4 Kilogram
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inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:36082-50-5
Min.Order:1 Gram
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:36082-50-5
Min.Order:10 Gram
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inquiryProduct name: 5-Bromo-2,4-Dichloropyrimidine CAS No.:36082-50-5 Molecule Formula:C4HBrCl2N2 Molecule Weight:227.87 Purity: 98.0% Package: 200kg/drum Description:Light yellow to colorless liquid Manufacture Standards:Enterprise Standar
Cas:36082-50-5
Min.Order:1 Kilogram
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Type:Trading Company
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:36082-50-5
Min.Order:1 Kilogram
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inquiry5-bromouracil
2,4-dichloro-5-bromopyrimidine
Conditions | Yield |
---|---|
With phosphorus pentachloride In 1,1,2-trichloroethane Reagent/catalyst; Solvent; Reflux; | 99.5% |
With N,N-dimethyl-aniline; trichlorophosphate at 120 - 130℃; for 1.33333h; | 96.6% |
With phosgene; Tributylphosphine oxide at -5 - 125℃; for 1.83333h; Inert atmosphere; | 89.7% |
2,4-dihydroxy-5-bromopyrimidine
2,4-dichloro-5-bromopyrimidine
Conditions | Yield |
---|---|
With pyridine; trichlorophosphate at 160℃; for 2h; Autoclave; neat (no solvent); | 91% |
With dmap; thionyl chloride; bis(trichloromethyl) carbonate for 12.5h; Reflux; Green chemistry; | 90% |
With phosphorus pentachloride; trichlorophosphate |
5-bromouracil
phosphorus pentachloride
trichlorophosphate
2,4-dichloro-5-bromopyrimidine
5-bromo-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one
2,4-dichloro-5-bromopyrimidine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; trichlorophosphate at 90℃; |
2,4-dichloro-5-bromopyrimidine
4-amino-5-bromo-2-chloropyrimidine
Conditions | Yield |
---|---|
With ammonia In methanol at 20℃; | 100% |
With ammonium hydroxide In tetrahydrofuran at 20℃; for 12h; | 100% |
With ammonium hydroxide In tetrahydrofuran; water at 20℃; for 1.5h; | 100% |
2,4-dichloro-5-bromopyrimidine
5-bromo-2-chloro-pyrimidin-4(3H)-one
Conditions | Yield |
---|---|
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 6h; Cooling; | 86% |
Stage #1: 2,4-dichloro-5-bromopyrimidine With sodium hydroxide In tetrahydrofuran at 20℃; for 3h; Stage #2: With hydrogenchloride In tetrahydrofuran | 64% |
Stage #1: 2,4-dichloro-5-bromopyrimidine With sodium hydroxide In tetrahydrofuran at 20℃; for 3h; Inert atmosphere; Stage #2: With hydrogenchloride In tetrahydrofuran; water Inert atmosphere; | 64% |
2,4-dichloro-5-bromopyrimidine
(2-aminophenyl)dimethyl phosphorus oxide
(2-((5-bromo-2-chloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide
Conditions | Yield |
---|---|
With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate In N,N-dimethyl-formamide at 65℃; for 8h; | 72% |
With potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate In N,N-dimethyl-formamide at 65℃; for 7h; | 66% |
With tetrabutylammonium hydrogensulfate; potassium carbonate In N,N-dimethyl-formamide at 65℃; for 7h; | 66% |
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 12h; | 2.96 g |
2,4-dichloro-5-bromopyrimidine
N-Boc-1,3-diaminopropane
(3-((5-bromo-2-chloropyrimidin-4-yl)amino)propyl)carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 20℃; for 3.5h; | 100% |
With triethylamine In acetonitrile at 20℃; for 0.5h; | 41% |
With triethylamine In acetonitrile at 0 - 20℃; | |
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol regioselective reaction; | |
With potassium carbonate In isopropyl alcohol at 80℃; for 24h; |
2,4-dichloro-5-bromopyrimidine
(3-aminophenyl)carbamic acid tert-butyl ester
tert-butyl (3-((5-bromo-2-chloropyrimidin-4-yl)amino)phenyl)carbamate
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide | 99% |
With potassium carbonate In N,N-dimethyl-formamide at 21℃; for 16h; Inert atmosphere; | 98% |
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12h; | 98% |
2,4-dichloro-5-bromopyrimidine
methylamine
5-bromo-2-chloro-N-methyl-pyrimidin-4-amine
Conditions | Yield |
---|---|
In methanol at 0 - 20℃; for 3.66667h; | 100% |
In methanol; water Cooling with ice; | 88% |
In methanol; ethanol at 0 - 20℃; for 3h; | 88% |
2,4-dichloro-5-bromopyrimidine
1-(tert-butoxycarbonyl)-4-aminopiperidine
tert-butyl 4-((5-bromo-2-chloropyrimidin-4-yl)amino)piperidine-1-carboxylate
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 20℃; for 0.5h; | 82% |
With trimethylamine In acetonitrile at 20℃; for 2h; | 82% |
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 20℃; | 67% |
2,4-dichloro-5-bromopyrimidine
benzyl alcohol
2,4-bis(benzyloxy)-5-bromopyrimidine
Conditions | Yield |
---|---|
With sodium hydride In toluene at 20 - 25℃; for 12h; | 93% |
With sodium hydride In toluene at 20℃; for 18h; | 91% |
With sodium hydride 1.) toluene, 50 deg C, 2.) toluene, 25 deg C, overnight; Yield given. Multistep reaction; | |
With sodium hydride |
2,4-dichloro-5-bromopyrimidine
4-Aminobutanol
4-((5-bromo-2-chloropyrimidin-4-yl)amino)butan-1-ol
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 0 - 20℃; for 16h; | 98% |
With triethylamine In acetonitrile at 0 - 20℃; for 16h; | 98% |
With triethylamine In butan-1-ol at 125℃; for 1h; Inert atmosphere; Microwave irradiation; | 77% |
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 80℃; for 0.333333h; Microwave irradiation; |
2,4-dichloro-5-bromopyrimidine
(3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine
(S)-tert-butyl 3-(5-bromo-2-chloropyrimidin-4-ylamino)pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane at 10 - 20℃; for 20h; | 67% |
With potassium carbonate In N,N-dimethyl-formamide | |
With potassium carbonate In acetonitrile at 0 - 20℃; | |
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 8h; | |
With potassium carbonate In acetonitrile at 20℃; |
2,4-dichloro-5-bromopyrimidine
1-(5-bromo-2-chloropyrimidine-4-yl)hydrazine
Conditions | Yield |
---|---|
With hydrazine hydrate In ethanol for 12h; Reflux; Inert atmosphere; | 100% |
With hydrazine hydrate In methanol at 20℃; for 1h; Cooling with ice; | 87% |
With hydrazine hydrate In ethanol at 5 - 20℃; for 1h; | 75% |
With hydrazine hydrate; triethylamine In ethanol at 20℃; for 1h; Cooling with ice; |
2,4-dichloro-5-bromopyrimidine
cyclohexylamine
5-bromo-2-chloro-N-cyclohexylpyrimidin-4-amine
Conditions | Yield |
---|---|
In tetrahydrofuran at 50℃; for 12h; | 95% |
With diisopropylamine In 1,4-dioxane at 20℃; for 6h; | 63% |
With sodium hydrogencarbonate In methanol at 20℃; for 6h; | 54% |
2,4-dichloro-5-bromopyrimidine
(R,R)-2,3-butandiol
(2R,3R)-3-[(5-bromo-2-chloropyrimidin-4-yl)oxy]butan-2-ol
Conditions | Yield |
---|---|
Stage #1: (R,R)-2,3-butandiol With sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.166667h; Stage #2: 2,4-dichloro-5-bromopyrimidine In tetrahydrofuran at 20℃; for 12h; | 81% |
Stage #1: (R,R)-2,3-butandiol With sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.166667h; Stage #2: 2,4-dichloro-5-bromopyrimidine In tetrahydrofuran at 0 - 20℃; for 12h; | 81% |
Stage #1: (R,R)-2,3-butandiol With sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.5h; Stage #2: 2,4-dichloro-5-bromopyrimidine In tetrahydrofuran at 0 - 20℃; for 12h; | 57% |
2,4-dichloro-5-bromopyrimidine
N-{3-[(3-cyano-propyl)-methanesulfonyl-amino]-phenyl}-acetamide
Conditions | Yield |
---|---|
Stage #1: 2,4-dichloro-5-bromopyrimidine; N-{3-[(3-cyano-propyl)-methanesulfonyl-amino]-phenyl}-acetamide With hydrogenchloride; hydrogen; platinum(IV) oxide In ethanol; water at 20℃; under 760.051 Torr; for 5h; Stage #2: 2,4-dichloro-5-bromopyrimidine With triethylamine In acetonitrile at 20℃; for 16h; | 43% |
2,4-dichloro-5-bromopyrimidine
2,2-dimethoxyethylamine
Conditions | Yield |
---|---|
With triethylamine In ethanol at 20℃; for 24h; | 83% |
With triethylamine In ethanol at 0 - 20℃; for 12h; | 77% |
Stage #1: 2,4-dichloro-5-bromopyrimidine; 2,2-dimethoxyethylamine In ethanol at 0℃; for 0.166667h; Inert atmosphere; Stage #2: With triethylamine In ethanol Inert atmosphere; | 64% |
With triethylamine In ethanol at 0 - 20℃; for 16.25h; |
2,4-dichloro-5-bromopyrimidine
D-alanine methyl ester hydrochloride
methyl N-(5-bromo-2-chloropyrimidin-4-yl)-D-alaninate
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran; N,N-dimethyl-formamide at 0 - 20℃; for 48h; | 86% |
With triethylamine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 48h; | 86% |
With triethylamine In tetrahydrofuran; N,N-dimethyl-formamide at 0 - 20℃; for 48h; | 86% |
2,4-dichloro-5-bromopyrimidine
meta-nitrophenol
Conditions | Yield |
---|---|
Stage #1: meta-nitrophenol With sodium hydride In dimethyl sulfoxide; N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: 2,4-dichloro-5-bromopyrimidine In dimethyl sulfoxide; N,N-dimethyl-formamide at 20℃; | 93% |
With potassium carbonate In N,N-dimethyl-formamide | |
With N-ethyl-N,N-diisopropylamine In ethanol at 0 - 20℃; |
2,4-dichloro-5-bromopyrimidine
4-fluoroaniline
5-bromo-2-chloro-4-[(4-fluorophenyl)amino]-pyrimidine
Conditions | Yield |
---|---|
With sodium acetate In tetrahydrofuran; water at 20℃; for 18h; | 90% |
With potassium carbonate In water; isopropyl alcohol at 20℃; for 18h; | 90% |
With sodium carbonate In ethanol at 20℃; for 16h; |
2,4-dichloro-5-bromopyrimidine
sodium methylate
5-bromo-2-chloro-4-methoxypyrimidine
Conditions | Yield |
---|---|
With methanol at 20℃; for 4h; | 93% |
In methanol at 20℃; for 4h; Cooling with ice; | 93% |
In methanol at 20℃; for 12h; | 90% |
2,4-dichloro-5-bromopyrimidine
tert-butyl 4-(aminomethyl)piperidine-1-carboxylate
4-[(5-bromo-2-chloro-pyrimidin-4-ylamino)methyl]-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With trimethylamine In acetonitrile at 20℃; for 2h; | 92% |
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 50℃; for 2h; Inert atmosphere; | 75% |
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 80℃; for 0.333333h; Microwave irradiation; |
2,4-dichloro-5-bromopyrimidine
4-methoxy-aniline
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In butan-1-ol at 100℃; | 72% |
With potassium carbonate In water; isopropyl alcohol at 20℃; | 51.4% |
Stage #1: 2,4-dichloro-5-bromopyrimidine; 4-methoxy-aniline In isopropyl alcohol at 20℃; Stage #2: With potassium carbonate In water at 20℃; | 51.4% |
2,4-dichloro-5-bromopyrimidine
5-aminobenzimidazole
(1H-Benzoimidazol-5-yl)-(5-bromo-2-chloro-pyrimidin-4-yl)-amine
Conditions | Yield |
---|---|
With sodium carbonate In ethanol at 20℃; for 24h; | 93% |
With sodium carbonate In ethanol at 20℃; for 16h; |
2,4-dichloro-5-bromopyrimidine
2,2-dimethylpropylamine
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 20℃; for 2h; | 70% |
With sodium hydrogencarbonate In methanol at 20℃; for 6h; | |
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 2h; |
2,4-dichloro-5-bromopyrimidine
sodium thiomethoxide
5-bromo-2-chloro-4-(methylthio)pyrimidine
Conditions | Yield |
---|---|
In acetonitrile at 20℃; | 82.8% |
In acetonitrile at 20℃; for 24h; | 70% |
In acetonitrile at 20℃; for 24h; | 70% |
2,4-dichloro-5-bromopyrimidine
N,N-dimethyl-formamide
2,4-dichloro-5-pyrimidinecarboxaldehyde
Conditions | Yield |
---|---|
Stage #1: 2,4-dichloro-5-bromopyrimidine With TurboGrignard In tetrahydrofuran at -78℃; for 2h; Bouveault Aldehyde Synthesis; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at -78 - -42℃; for 12h; | 38% |
Stage #1: 2,4-dichloro-5-bromopyrimidine With isopropylmagnesium chloride; lithium chloride In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at -78 - -35℃; for 4h; | 31% |
Stage #1: 2,4-dichloro-5-bromopyrimidine With hydrogenchloride In tetrahydrofuran at -78 - 35℃; for 0.5h; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at -78℃; for 2h; | 28% |
4-morpholinecarboxaldehyde
2,4-dichloro-5-bromopyrimidine
2,4-dichloro-5-pyrimidinecarboxaldehyde
Conditions | Yield |
---|---|
Stage #1: 2,4-dichloro-5-bromopyrimidine With TurboGrignard In tetrahydrofuran at -78 - -42℃; for 1.25h; Stage #2: 4-morpholinecarboxaldehyde In tetrahydrofuran at -78 - -42℃; for 3.91667h; | 87% |
Stage #1: 2,4-dichloro-5-bromopyrimidine With TurboGrignard In tetrahydrofuran at 78℃; for 1h; Stage #2: 4-morpholinecarboxaldehyde In tetrahydrofuran at -78 - -35℃; for 1.5h; Stage #3: With hydrogenchloride; water In tetrahydrofuran at -35℃; | 71% |
indole
2,4-dichloro-5-bromopyrimidine
3-(5-Bromo-2-chloropyrimidin-4-yl)-1H-indole
Conditions | Yield |
---|---|
Stage #1: 2,4-dichloro-5-bromopyrimidine With aluminum (III) chloride In 1,2-dichloro-ethane at 80℃; for 0.5h; Stage #2: indole In 1,2-dichloro-ethane at 80℃; for 18h; | 98% |
Stage #1: indole With methylmagnesium bromide In tetrahydrofuran; diethyl ether at 0℃; for 0.75h; Inert atmosphere; Stage #2: 2,4-dichloro-5-bromopyrimidine In tetrahydrofuran; diethyl ether at 0 - 60℃; for 2.25h; Inert atmosphere; | 75% |
2,4-dichloro-5-bromopyrimidine
m-bromobenzoic aldehyde
(3-bromo-phenyl)-(2,4-dichloro-pyrimidin-5-yl)-methanol
Conditions | Yield |
---|---|
Stage #1: 2,4-dichloro-5-bromopyrimidine With isopropylmagnesium chloride In tetrahydrofuran at -35℃; for 1h; Inert atmosphere; Stage #2: m-bromobenzoic aldehyde In tetrahydrofuran at -35℃; for 2h; Inert atmosphere; Stage #3: With water In tetrahydrofuran Inert atmosphere; | 98.8% |
Stage #1: 2,4-dichloro-5-bromopyrimidine With isopropylmagnesium chloride In tetrahydrofuran at -35℃; for 1h; Inert atmosphere; Stage #2: m-bromobenzoic aldehyde at -35℃; for 2h; | 98.8% |
2,4-dichloro-5-bromopyrimidine
1-t-Butoxycarbonylpiperazine
tert-butyl 4-(5-bromo-2-chloropyrimidin-4-yl)piperazine-1-carboxylate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 30℃; for 2h; | 89% |
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 80℃; for 0.333333h; Microwave irradiation; |
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