Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h
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Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
Name Dimebolin Synonyms 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-1H-pyrido[4,3-b]indole Molecular Structure
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Nanjing Sunsure Chemical Technology Co., Ltd., established in 2009, has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. Sunsure covers whole
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inquiry2-methyl-5-vinylpyridine
2.8-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
dimebon
Conditions | Yield |
---|---|
With potassium phosphate In ISOPROPYLAMIDE at 100℃; for 24h; Inert atmosphere; | 80% |
With potassium hydroxide In 1-methyl-pyrrolidin-2-one at 100℃; | 55% |
With potassium hydroxide In diethylene glycol dimethyl ether at 120℃; for 42h; Product distribution / selectivity; | 52% |
With sodium ethanolate; sodium In dimethyl sulfoxide at 90 - 95℃; | |
With potassium phosphate In ISOPROPYLAMIDE at 130℃; |
tert-butyl 8-methyl-5-(2-(6-methylpyridin-3-yl)ethyl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate
dimebon
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran for 2h; Reflux; | 70% |
1-Methyl-4-piperidone
2-methyl-5-{2-[1-(4-methylphenyl)hydrazinyl]ethyl}pyridine
dimebon
Conditions | Yield |
---|---|
With acetic acid In water at 20℃; for 4h; Inert atmosphere; Reflux; | |
With hydrogenchloride In isopropyl alcohol for 0.25h; |
N'-(1-methyl-piperidin-4-ylidene)-N-[2-(6-methyl-pyridin-3-yl)-ethyl]-N-p-tolyl-hydrazine
dimebon
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water at 100℃; for 0.5h; | |
Stage #1: N'-(1-methyl-piperidin-4-ylidene)-N-[2-(6-methyl-pyridin-3-yl)-ethyl]-N-p-tolyl-hydrazine With hydrogenchloride; water In ethanol at 80℃; for 1.5h; Stage #2: With sodium hydroxide In ethanol; water pH=14; | |
Stage #1: N'-(1-methyl-piperidin-4-ylidene)-N-[2-(6-methyl-pyridin-3-yl)-ethyl]-N-p-tolyl-hydrazine With hydrogenchloride In ethanol at 80℃; for 1.5h; Reflux; Stage #2: With sodium hydroxide In ethanol; water pH=14; |
dimebon
Conditions | Yield |
---|---|
With sodium hydroxide In 2-methyltetrahydrofuran; water for 1.25h; |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0 °C / Reflux; Inert atmosphere 1.2: 1 h / Inert atmosphere 2.1: phosphorus tribromide / diethyl ether / 3 h / 0 °C / Inert atmosphere 3.1: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere 4.1: sodium tetrahydroborate / methanol; water / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: potassium phosphate / ISOPROPYLAMIDE / 22 h / 100 °C 2: hydrogenchloride / isopropyl alcohol / 0.25 h View Scheme |
2-(6-methylpyridin-3-yl) ethan-1-ol
dimebon
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: phosphorus tribromide / diethyl ether / 3 h / 0 °C / Inert atmosphere 2: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere 3: sodium tetrahydroborate / methanol; water / Inert atmosphere View Scheme |
dimebon
Conditions | Yield |
---|---|
With sodium tetrahydroborate In methanol; water Inert atmosphere; | 0.046 g |
3-(2-azido-5-methylphenyl)pyridine
dimebon
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: dichloromethane / 20 °C / Inert atmosphere 2: dirhodium(II) tetrakis(perfluorobutyrate) / toluene / 15 h / 90 °C / Inert atmosphere; Molecular sieve 3: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere 4: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere 5: sodium tetrahydroborate / methanol; water / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1: dichloromethane / 20 °C / Inert atmosphere 2: ruthenium trichloride hydrate / Isopropyl acetate / 15 h / 80 °C / Inert atmosphere 3: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere 4: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere 5: sodium tetrahydroborate / methanol; water / Inert atmosphere View Scheme |
1-methyl-3-(2-azido-5-methylphenyl)pyridinium triflate
dimebon
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: dirhodium(II) tetrakis(perfluorobutyrate) / toluene / 15 h / 90 °C / Inert atmosphere; Molecular sieve 2: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere 3: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere 4: sodium tetrahydroborate / methanol; water / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1: ruthenium trichloride hydrate / Isopropyl acetate / 15 h / 80 °C / Inert atmosphere 2: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere 3: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere 4: sodium tetrahydroborate / methanol; water / Inert atmosphere View Scheme |
CF3O3S(1-)*C13H13N2(1+)
dimebon
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere 2: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere 3: sodium tetrahydroborate / methanol; water / Inert atmosphere View Scheme |
3-(2-amino-5-methylphenyl)pyridine
dimebon
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: acetic acid; sodium nitrite / water / 1.5 h / 0 °C / Inert atmosphere 1.2: 0 - 20 °C / Inert atmosphere 2.1: dichloromethane / 20 °C / Inert atmosphere 3.1: dirhodium(II) tetrakis(perfluorobutyrate) / toluene / 15 h / 90 °C / Inert atmosphere; Molecular sieve 4.1: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere 5.1: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere 6.1: sodium tetrahydroborate / methanol; water / Inert atmosphere View Scheme | |
Multi-step reaction with 6 steps 1.1: acetic acid; sodium nitrite / water / 1.5 h / 0 °C / Inert atmosphere 1.2: 0 - 20 °C / Inert atmosphere 2.1: dichloromethane / 20 °C / Inert atmosphere 3.1: ruthenium trichloride hydrate / Isopropyl acetate / 15 h / 80 °C / Inert atmosphere 4.1: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere 5.1: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere 6.1: sodium tetrahydroborate / methanol; water / Inert atmosphere View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 2.5 h / 80 °C / Inert atmosphere 2.1: acetic acid; sodium nitrite / water / 1.5 h / 0 °C / Inert atmosphere 2.2: 0 - 20 °C / Inert atmosphere 3.1: dichloromethane / 20 °C / Inert atmosphere 4.1: dirhodium(II) tetrakis(perfluorobutyrate) / toluene / 15 h / 90 °C / Inert atmosphere; Molecular sieve 5.1: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere 6.1: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere 7.1: sodium tetrahydroborate / methanol; water / Inert atmosphere View Scheme | |
Multi-step reaction with 7 steps 1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 2.5 h / 80 °C / Inert atmosphere 2.1: acetic acid; sodium nitrite / water / 1.5 h / 0 °C / Inert atmosphere 2.2: 0 - 20 °C / Inert atmosphere 3.1: dichloromethane / 20 °C / Inert atmosphere 4.1: ruthenium trichloride hydrate / Isopropyl acetate / 15 h / 80 °C / Inert atmosphere 5.1: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere 6.1: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere 7.1: sodium tetrahydroborate / methanol; water / Inert atmosphere View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 2.5 h / 80 °C / Inert atmosphere 2.1: acetic acid; sodium nitrite / water / 1.5 h / 0 °C / Inert atmosphere 2.2: 0 - 20 °C / Inert atmosphere 3.1: dichloromethane / 20 °C / Inert atmosphere 4.1: dirhodium(II) tetrakis(perfluorobutyrate) / toluene / 15 h / 90 °C / Inert atmosphere; Molecular sieve 5.1: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere 6.1: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere 7.1: sodium tetrahydroborate / methanol; water / Inert atmosphere View Scheme | |
Multi-step reaction with 7 steps 1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 2.5 h / 80 °C / Inert atmosphere 2.1: acetic acid; sodium nitrite / water / 1.5 h / 0 °C / Inert atmosphere 2.2: 0 - 20 °C / Inert atmosphere 3.1: dichloromethane / 20 °C / Inert atmosphere 4.1: ruthenium trichloride hydrate / Isopropyl acetate / 15 h / 80 °C / Inert atmosphere 5.1: potassium hydroxide / water / 2 h / 90 °C / Inert atmosphere 6.1: N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere 7.1: sodium tetrahydroborate / methanol; water / Inert atmosphere View Scheme |
2-methyl-5-{2-[1-(4-methylphenyl)hydrazinyl]ethyl}pyridine
dimebon
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: toluene / 24 h / 120 °C 2.1: hydrogenchloride; water / ethanol / 1.5 h / 80 °C 2.2: pH 14 View Scheme | |
Multi-step reaction with 2 steps 1.1: toluene / 24 h / 120 °C 2.1: hydrogenchloride / ethanol / 1.5 h / 80 °C / Reflux 2.2: pH 14 View Scheme |
dimebon
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydroxide / ethanol; water / 0.5 h / 60 °C / Inert atmosphere 1.2: 12 h / 60 °C / Inert atmosphere 2.1: toluene / 24 h / 120 °C 3.1: hydrogenchloride; water / ethanol / 1.5 h / 80 °C 3.2: pH 14 View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: sodium hydride / N,N-dimethyl-formamide; toluene / 10 h / 80 °C 1.2: 2 h / 110 °C 1.3: pH 9 2.1: sulfur / 7 h / 110 °C 3.1: sodium hydroxide; water / ethanol / 17 h / 80 °C 3.2: pH 2 4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C 5.1: sodium tetrahydroborate; acetic acid / 1,4-dioxane / 3.5 h / 10 - 105 °C 6.1: hydrogenchloride / water / 30 °C 6.2: 1 h / 0 - 20 °C 6.3: 1 h 7.1: sodium hydroxide / ethanol; water / 0.5 h / 60 °C / Inert atmosphere 7.2: 12 h / 60 °C / Inert atmosphere 8.1: toluene / 24 h / 120 °C 9.1: hydrogenchloride / ethanol / 1.5 h / 80 °C / Reflux 9.2: pH 14 View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C 2.1: sodium tetrahydroborate; acetic acid / 1,4-dioxane / 3.5 h / 10 - 105 °C 3.1: hydrogenchloride / water / 30 °C 3.2: 1 h / 0 - 20 °C 3.3: 1 h 4.1: sodium hydroxide / ethanol; water / 0.5 h / 60 °C / Inert atmosphere 4.2: 12 h / 60 °C / Inert atmosphere 5.1: toluene / 24 h / 120 °C 6.1: hydrogenchloride / ethanol / 1.5 h / 80 °C / Reflux 6.2: pH 14 View Scheme |
2-(6-methylpyridin-3-yl)acetic acid
dimebon
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C 2.1: sodium tetrahydroborate; acetic acid / 1,4-dioxane / 3.5 h / 10 - 105 °C 3.1: hydrogenchloride / water / 30 °C 3.2: 1 h / 0 - 20 °C 3.3: 1 h 4.1: sodium hydroxide / ethanol; water / 0.5 h / 60 °C / Inert atmosphere 4.2: 12 h / 60 °C / Inert atmosphere 5.1: toluene / 24 h / 120 °C 6.1: hydrogenchloride / ethanol / 1.5 h / 80 °C / Reflux 6.2: pH 14 View Scheme |
1-(6-methyl-pyridin-3-yl)-ethanone
dimebon
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: sulfur / 7 h / 110 °C 2.1: sodium hydroxide; water / ethanol / 17 h / 80 °C 2.2: pH 2 3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C 4.1: sodium tetrahydroborate; acetic acid / 1,4-dioxane / 3.5 h / 10 - 105 °C 5.1: hydrogenchloride / water / 30 °C 5.2: 1 h / 0 - 20 °C 5.3: 1 h 6.1: sodium hydroxide / ethanol; water / 0.5 h / 60 °C / Inert atmosphere 6.2: 12 h / 60 °C / Inert atmosphere 7.1: toluene / 24 h / 120 °C 8.1: hydrogenchloride / ethanol / 1.5 h / 80 °C / Reflux 8.2: pH 14 View Scheme |
N-(4-methylphenyl)-2-(6-methylpyridin-3-yl)acetamide
dimebon
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium tetrahydroborate; acetic acid / 1,4-dioxane / 3.5 h / 10 - 105 °C 2.1: hydrogenchloride / water / 30 °C 2.2: 1 h / 0 - 20 °C 2.3: 1 h 3.1: sodium hydroxide / ethanol; water / 0.5 h / 60 °C / Inert atmosphere 3.2: 12 h / 60 °C / Inert atmosphere 4.1: toluene / 24 h / 120 °C 5.1: hydrogenchloride / ethanol / 1.5 h / 80 °C / Reflux 5.2: pH 14 View Scheme |
4-methyl-N-(2-(6-methylpyridin-3-yl)ethyl)aniline
dimebon
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: hydrogenchloride / water / 30 °C 1.2: 1 h / 0 - 20 °C 1.3: 1 h 2.1: sodium hydroxide / ethanol; water / 0.5 h / 60 °C / Inert atmosphere 2.2: 12 h / 60 °C / Inert atmosphere 3.1: toluene / 24 h / 120 °C 4.1: hydrogenchloride / ethanol / 1.5 h / 80 °C / Reflux 4.2: pH 14 View Scheme |
4-methyl-N-[2-(6-methylpyridin-3-yl)ethyl]-N-nitrosoaniline
dimebon
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydroxide / ethanol; water / 0.5 h / 60 °C / Inert atmosphere 1.2: 12 h / 60 °C / Inert atmosphere 2.1: toluene / 24 h / 120 °C 3.1: hydrogenchloride / ethanol / 1.5 h / 80 °C / Reflux 3.2: pH 14 View Scheme |
4-[(6-methyl-pyridin-3-yl)-thioacetyl]-morpholine
dimebon
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: sodium hydroxide; water / ethanol / 17 h / 80 °C 1.2: pH 2 2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C 3.1: sodium tetrahydroborate; acetic acid / 1,4-dioxane / 3.5 h / 10 - 105 °C 4.1: hydrogenchloride / water / 30 °C 4.2: 1 h / 0 - 20 °C 4.3: 1 h 5.1: sodium hydroxide / ethanol; water / 0.5 h / 60 °C / Inert atmosphere 5.2: 12 h / 60 °C / Inert atmosphere 6.1: toluene / 24 h / 120 °C 7.1: hydrogenchloride / ethanol / 1.5 h / 80 °C / Reflux 7.2: pH 14 View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrogenchloride / water / 20 - 55 °C / Industry scale 1.2: 2.5 h / 5 - 45 °C / pH 12.4 / Industry scale 2.1: potassium hydroxide / diethylene glycol dimethyl ether / 42 h / 120 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrogenchloride / water / 20 - 55 °C / Industry scale 1.2: 2.5 h / 5 - 45 °C / pH 12.4 / Industry scale 2.1: potassium hydroxide / diethylene glycol dimethyl ether / 42 h / 120 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium phosphate / ISOPROPYLAMIDE / 22 h / 100 °C 2: hydrogenchloride / isopropyl alcohol / 0.25 h View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: butyl magnesium bromide; methyllithium / tetrahydrofuran / 0.5 h / -10 - 0 °C 1.2: 1 h 1.3: 1 h / 40 °C 2.1: thionyl chloride; sodium hydroxide / Isopropyl acetate 2.2: 4 h / 50 °C 3.1: potassium hydroxide / diethylene glycol dimethyl ether / 42 h / 120 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: butyl magnesium bromide; methyllithium / tetrahydrofuran / 0.5 h / -10 - 0 °C 1.2: 1 h 1.3: 1 h / 40 °C 2.1: thionyl chloride; sodium hydroxide / Isopropyl acetate 2.2: 4 h / 50 °C 3.1: potassium phosphate / ISOPROPYLAMIDE / 22 h / 100 °C 4.1: hydrogenchloride / isopropyl alcohol / 0.25 h View Scheme |
dimebon
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: thionyl chloride; sodium hydroxide / Isopropyl acetate 1.2: 4 h / 50 °C 2.1: potassium hydroxide / diethylene glycol dimethyl ether / 42 h / 120 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: thionyl chloride; sodium hydroxide / Isopropyl acetate 1.2: 4 h / 50 °C 2.1: potassium phosphate / ISOPROPYLAMIDE / 22 h / 100 °C 3.1: hydrogenchloride / isopropyl alcohol / 0.25 h View Scheme |
dimebon
Conditions | Yield |
---|---|
In ethanol at 45 - 50℃; | 93.9% |
dimebon
Conditions | Yield |
---|---|
With hydrogenchloride In acetone at 45 - 65℃; for 0.666667h; Inert atmosphere; | 84% |
With hydrogenchloride In methanol; water at 0℃; for 2h; pH=2 - 3; | 83% |
With hydrogenchloride In methanol at 0℃; for 2h; pH=2 - 3; | 83% |
With hydrogenchloride In methanol; water at 20℃; for 2h; | 70% |
iodomethyl diisopropylcarbamate
dimebon
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; | 39% |
iodomethyl diisopropylcarbamate
dimebon
2-(((diisopropylcarbamoyl)oxy)methyl)-2,8-dimethyl-5-(2-(6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-2-ium iodide
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; | 15% |
dimebon
2,3,4,5-tetrahydro-2,8-dimethyl-5-(2-(6-methylpyridin-3-yl)ethyl)-1H-pyrido[4,3-b]indole N,N'-dioxide
Conditions | Yield |
---|---|
With dihydrogen peroxide; acetic acid In water at 65 - 70℃; for 20h; |
dimebon
C21H21N3O3
Conditions | Yield |
---|---|
With selenium(IV) oxide In pyridine at 80℃; for 48h; |
dimebon
2,8-dimethyl-5-(2-(6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 2-oxide
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 25℃; for 24h; |
dimebon
Conditions | Yield |
---|---|
With borane-THF In tetrahydrofuran at 20℃; |
dimebon
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium tetrahydroborate; trifluoroacetic acid / 3 h / 20 °C 1.2: pH 10 - 10.5 2.1: hydrogen bromide / ethanol; water / 0.5 h View Scheme |
dimebon
Conditions | Yield |
---|---|
Stage #1: dimebon With sodium tetrahydroborate; trifluoroacetic acid at 20℃; for 3h; Stage #2: With sodium hydroxide In water pH=10 - 10.5; stereoselective reaction; |
dimebon
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: borane-THF / tetrahydrofuran / 20 °C 2.1: hydrogenchloride / 1,4-dioxane; water / 2 h / Reflux 2.2: pH 10 - 10.5 3.1: hydrogen bromide / ethanol; water / 0.5 h View Scheme |
dimebon
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: borane-THF / tetrahydrofuran / 20 °C 2.1: hydrogenchloride / 1,4-dioxane; water / 2 h / Reflux 2.2: pH 10 - 10.5 View Scheme |
dimebon
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium tetrahydroborate; trifluoroacetic acid / 3 h / 20 °C 1.2: pH 10 - 10.5 2.1: hydrogen bromide / ethanol; water / 0.5 h 3.1: oxygen / ethanol View Scheme |
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