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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

2-Chloro-6-fluoroaniline Manufacturer/High quality/Best price/In stock

Cas:363-51-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: 2-Chloro-6-fluoroaniline Synonyms: 2-Chloro-6-fluoroani;2-Amino-3-fluorochlorobenzene;2-Chloro-6-fluoroaniline, 99% 1GR;2-Chloro-6-fluoroaniline 98+%;Chloro-6-fluoroanil;2-chloro-6-fluorobenzenamine;2-CHLORO-6-FLU

363-51-9 2-Chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:1 Kilogram

FOB Price: $8900.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 363-51-9 with fast shipping

Cas:363-51-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzenamine, 2-chloro-6-fluoro- 363-51-9

Cas:363-51-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At presen

2-Chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:1 Gram

FOB Price: $95.0 / 100.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:363-51-9

Cas:363-51-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Factory Supply High Quality CAS 363-51-9 ,2-Chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

superior quality Appearance: Clear pale yellow liquid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceutical Intermediates Transpo

2-chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-Chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

2-Chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply 2-chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:0

Negotiable

Type:Other

inquiry

Siwei Development Group Ltd.

Product name: 2-Chloro-6-Fluoroaniline CAS No.:363-51-9 Molecule Formula:C6H5ClFN Molecule Weight:145.56 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard

High Quality 2-Chloro-6-Fluoroaniline

Cas:363-51-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

2-Chloro-6-fluoroaniline Basic information Product Name: 2-Chloro-6-fluoroaniline Synonyms: 2-Chloro-6-fluoroani;2-Amino-3-fluorochlorobenzene;2-Chloro-6-fluoroaniline, 99% 1GR;2-Chloro-6-fluoroaniline 98+%;Chloro-6-fluoroanil;2-chloro-6-fluoro

2-Chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

2-Chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2-Chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-Chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

2-Chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermediat

2-Chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:1 Kilogram

FOB Price: $5.0 / 15.0

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

2-Chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

2-Chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2-Chloro-6-Fluoroaniline cas no. 363-51-9 98%

Cas:363-51-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

2-chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

2-Chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

2-Chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

2-Chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

2-chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

2-Chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

2-Chloro-6-fluoroaniline

Cas:363-51-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

2'-Chloro-6'-fluorobenzanilide
90493-88-2

2'-Chloro-6'-fluorobenzanilide

2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

Conditions
ConditionsYield
With sulfuric acid for 3h; Heating;71%
2-chloro-6-fluorobenzoic acid
434-75-3

2-chloro-6-fluorobenzoic acid

2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

Conditions
ConditionsYield
With sodium azide; sulfuric acid
With hydrogenchloride; sodium hydroxide; sulfuric acid In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; chloroform
N-(2-fluorophenyl)hydroxylamine
2369-21-3

N-(2-fluorophenyl)hydroxylamine

2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaHCO3 / diethyl ether; H2O / 1 h / T < 5 deg C; or in benzene
2: 75 percent / SOCl2 / diethyl ether / 1 h / T < 5 deg C
3: 71 percent / 70percent H2SO4 / 3 h / Heating
View Scheme
N-(2-Fluorophenyl)benzohydroxamic acid
90493-82-6

N-(2-Fluorophenyl)benzohydroxamic acid

2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 75 percent / SOCl2 / diethyl ether / 1 h / T < 5 deg C
2: 71 percent / 70percent H2SO4 / 3 h / Heating
View Scheme
ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Zinc dust, NH4Cl (or NH4Br)
2: NaHCO3 / diethyl ether; H2O / 1 h / T < 5 deg C; or in benzene
3: 75 percent / SOCl2 / diethyl ether / 1 h / T < 5 deg C
4: 71 percent / 70percent H2SO4 / 3 h / Heating
View Scheme
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

(2-ethoxyphenyl)boronic acid
213211-69-9

(2-ethoxyphenyl)boronic acid

C14H14FNO

C14H14FNO

Conditions
ConditionsYield
With palladium diacetate; 2-dicyclohexylphosphino-2',6'-dimethylbiphenyl In toluene at 100℃; for 3h;99%
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

4-nitro-benzoic acid
62-23-7

4-nitro-benzoic acid

C13H8ClFN2O3

C13H8ClFN2O3

Conditions
ConditionsYield
With covalent organic polymer from p-aminophenol and cyanuric chloride In 1,4-dioxane at 20℃; for 0.666667h;94%
4-Cyanochlorobenzene
623-03-0

4-Cyanochlorobenzene

2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

4-(2-chloro-6-fluorophenylamino)benzonitrile
817621-48-0

4-(2-chloro-6-fluorophenylamino)benzonitrile

Conditions
ConditionsYield
Stage #1: 2-chloro-6-fluoroaniline With sodium hydride In N,N-dimethyl-formamide at 0 - 4℃; for 1h;
Stage #2: 4-Cyanochlorobenzene In N,N-dimethyl-formamide at 50 - 55℃; for 20h;
91%
para-bromotoluene
106-38-7

para-bromotoluene

2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

N-(2-chloro-6-fluoro-phenyl)-4-methylaniline
332903-74-9

N-(2-chloro-6-fluoro-phenyl)-4-methylaniline

Conditions
ConditionsYield
With tri-tert-butyl phosphine; sodium t-butanolate; bis(dibenzylideneacetone)-palladium(0) In toluene at 110℃; for 14h; Buchwald-Hartwig coupling;90%
o-fluorobenzyl bromide
446-48-0

o-fluorobenzyl bromide

2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

potassium ethyl xanthogenate
140-89-6

potassium ethyl xanthogenate

4-fluoro-2-(2-fluoro-benzylsulfanyl)-benzothiazole

4-fluoro-2-(2-fluoro-benzylsulfanyl)-benzothiazole

Conditions
ConditionsYield
Stage #1: 2-chloro-6-fluoroaniline; potassium ethyl xanthogenate In N,N-dimethyl-formamide at 120℃; for 0.25h; microwave irradiation;
Stage #2: o-fluorobenzyl bromide In N,N-dimethyl-formamide at 90℃; for 0.1h; microwave irradiation;
90%
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

4-bromo-2-chloro-6-fluorobenzeneamine

4-bromo-2-chloro-6-fluorobenzeneamine

Conditions
ConditionsYield
With bromine In chloroform88%
With bromine In chloroform at 20℃; for 2h;83%
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

acetic anhydride
108-24-7

acetic anhydride

N-(2-chloro-6-fluorophenyl)acetamide
343-73-7

N-(2-chloro-6-fluorophenyl)acetamide

Conditions
ConditionsYield
With acetic acid at 90℃; for 2h;88%
With acetic acid at 90℃; for 1h;
Stage #1: 2-chloro-6-fluoroaniline; acetic anhydride With acetic acid at 90℃; for 1h;
Stage #2: With sodium hydroxide In water
With acetic acid at 90℃; for 2h;
With acetic acid at 90℃; for 2h;
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

4-bromo-2-butoxy-5-fluorobenzoic acid

4-bromo-2-butoxy-5-fluorobenzoic acid

4-bromo-2-butoxy-N-(2-chloro-6-fluorophenyl)-5-fluorobenzamide

4-bromo-2-butoxy-N-(2-chloro-6-fluorophenyl)-5-fluorobenzamide

Conditions
ConditionsYield
Stage #1: 4-bromo-2-butoxy-5-fluorobenzoic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide for 1h;
Stage #2: 2-chloro-6-fluoroaniline With triethylamine In dichloromethane for 1h;
88%
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

2,6-Difluorobenzyl bromide
85118-00-9

2,6-Difluorobenzyl bromide

potassium ethyl xanthogenate
140-89-6

potassium ethyl xanthogenate

2-(2,6-difluoro-benzylsulfanyl)-4-fluoro-benzothiazole

2-(2,6-difluoro-benzylsulfanyl)-4-fluoro-benzothiazole

Conditions
ConditionsYield
Stage #1: 2-chloro-6-fluoroaniline; potassium ethyl xanthogenate In N,N-dimethyl-formamide at 120℃; for 0.25h; microwave irradiation;
Stage #2: 2,6-Difluorobenzyl bromide In N,N-dimethyl-formamide at 90℃; for 0.1h; microwave irradiation;
86%
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

potassium ethyl xanthogenate
140-89-6

potassium ethyl xanthogenate

alpha-bromo-3,4-difluorotoluene
85118-01-0

alpha-bromo-3,4-difluorotoluene

2-(3,4-difluoro-benzylsulfanyl)-4-fluoro-benzothiazole

2-(3,4-difluoro-benzylsulfanyl)-4-fluoro-benzothiazole

Conditions
ConditionsYield
Stage #1: 2-chloro-6-fluoroaniline; potassium ethyl xanthogenate In N,N-dimethyl-formamide at 120℃; for 0.25h; microwave irradiation;
Stage #2: alpha-bromo-3,4-difluorotoluene In N,N-dimethyl-formamide at 90℃; for 0.1h; microwave irradiation;
86%
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

isopropyl 6-(3-((benzyloxy)methyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-2-(2-ethoxyvinyl)-5-fluoronicotinate

isopropyl 6-(3-((benzyloxy)methyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-2-(2-ethoxyvinyl)-5-fluoronicotinate

2-(3-((benzyloxy)methyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-6-(2-chloro-6-fluorophenyl)-3-fluoro-1,6-naphthyridin-5(6H)-one

2-(3-((benzyloxy)methyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-6-(2-chloro-6-fluorophenyl)-3-fluoro-1,6-naphthyridin-5(6H)-one

Conditions
ConditionsYield
Stage #1: 2-chloro-6-fluoroaniline With trimethylaluminum In dichloromethane at 0℃; for 0.0833333h; Inert atmosphere;
Stage #2: isopropyl 6-(3-((benzyloxy)methyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-2-(2-ethoxyvinyl)-5-fluoronicotinate In dichloromethane; toluene at 20 - 50℃;
86%
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

4-bromo-5-fluoro-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}benzoyl chloride

4-bromo-5-fluoro-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}benzoyl chloride

4-bromo-N-(2-chloro-6-fluorophenyl)-5-fluoro-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}benzamide

4-bromo-N-(2-chloro-6-fluorophenyl)-5-fluoro-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}benzamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 0.5h;84.5%
With triethylamine In dichloromethane at 20℃; for 0.5h;84.5%
With triethylamine In dichloromethane at 20℃; for 0.5h;39.3 g
With triethylamine In dichloromethane at 25℃; for 16.5h;
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

2,4,5-trifluorobenzoyl chloride
88419-56-1

2,4,5-trifluorobenzoyl chloride

N-(2-chloro-6-fluorophenyl)-2,4,5-trifluorobenzamide

N-(2-chloro-6-fluorophenyl)-2,4,5-trifluorobenzamide

Conditions
ConditionsYield
With pyridine In dichloromethane at 25℃; for 16h; Inert atmosphere;83.43%
5-bromo-1,3-xylene
556-96-7

5-bromo-1,3-xylene

2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

(2-chloro-6-fluorophenyl)(3,5-dimethylphenyl)amine
1041144-10-8

(2-chloro-6-fluorophenyl)(3,5-dimethylphenyl)amine

Conditions
ConditionsYield
With sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate; palladium diacetate In toluene for 18h; Heating;83%
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

trifluoroacetic acid
76-05-1

trifluoroacetic acid

(Z)-N-(2-chloro-6-fluorophenyl)-2,2,2-trifluoroacetimidoyl chloride

(Z)-N-(2-chloro-6-fluorophenyl)-2,2,2-trifluoroacetimidoyl chloride

Conditions
ConditionsYield
Stage #1: trifluoroacetic acid With tetrachloromethane; triethylamine; triphenylphosphine at 0℃; for 0.5h; Inert atmosphere;
Stage #2: 2-chloro-6-fluoroaniline With tetrachloromethane at 80℃; for 3.16667h; Inert atmosphere;
82%
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

5-((benzyloxy)methyl)-4-ethyl-2-(7-fluoro-4-isopropyl-1-oxo-1H-isochromen-6-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one

5-((benzyloxy)methyl)-4-ethyl-2-(7-fluoro-4-isopropyl-1-oxo-1H-isochromen-6-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one

6-(3-((benzyloxy)methyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-2-(2-chloro-6-fluorophenyl)-7-fluoro-4-isopropylisoquinolin-1(2H)-one

6-(3-((benzyloxy)methyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-2-(2-chloro-6-fluorophenyl)-7-fluoro-4-isopropylisoquinolin-1(2H)-one

Conditions
ConditionsYield
Stage #1: 2-chloro-6-fluoroaniline With trimethylaluminum In dichloromethane at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 5-((benzyloxy)methyl)-4-ethyl-2-(7-fluoro-4-isopropyl-1-oxo-1H-isochromen-6-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one In dichloromethane at 20℃; Inert atmosphere;
82%
4-chloroquinoline
611-35-8

4-chloroquinoline

2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

10-fluoro-11H-indolo[3,2-c]quinoline
1111618-76-8

10-fluoro-11H-indolo[3,2-c]quinoline

Conditions
ConditionsYield
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine In 1,4-dioxane; toluene at 125℃; for 24h; Inert atmosphere;80%
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

2-methoxy-4,6-dimethylbenzeneboronic acid
355836-08-7

2-methoxy-4,6-dimethylbenzeneboronic acid

C15H16FNO

C15H16FNO

Conditions
ConditionsYield
With palladium diacetate; 2-dicyclohexylphosphino-2',6'-dimethylbiphenyl In toluene at 100℃; for 1.5h;80%
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

isopropyl 6-(3-((benzyloxy)methyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-2-chloro-5-fluoronicotinate

isopropyl 6-(3-((benzyloxy)methyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-2-chloro-5-fluoronicotinate

6-(3-((benzyloxy)methyl)-4-ethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)-2-chloro-N-(2-chloro-6-fluorophenyl)-5-fluoronicotinamide

6-(3-((benzyloxy)methyl)-4-ethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)-2-chloro-N-(2-chloro-6-fluorophenyl)-5-fluoronicotinamide

Conditions
ConditionsYield
With trimethylaluminium In tetrahydrofuran; dichloromethane at 0 - 60℃; for 18.5h; Inert atmosphere;79%
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

(1-adamantyl)methyl isocyanate
69887-12-3

(1-adamantyl)methyl isocyanate

1-(adamantan-1-ylmethyl)-3-(6-chloro-2-fluorophenyl)urea

1-(adamantan-1-ylmethyl)-3-(6-chloro-2-fluorophenyl)urea

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 25℃; for 12h;79%
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

4-bromo-5-fluoro-2-[(2S)-pentan-2-yloxy]benzoic acid

4-bromo-5-fluoro-2-[(2S)-pentan-2-yloxy]benzoic acid

4-bromo-N-(2-chloro-6-fluorophenyl)-5-fluoro-2-[(2S)-pentan-2-yloxy]benzamide

4-bromo-N-(2-chloro-6-fluorophenyl)-5-fluoro-2-[(2S)-pentan-2-yloxy]benzamide

Conditions
ConditionsYield
Stage #1: 4-bromo-5-fluoro-2-[(2S)-pentan-2-yloxy]benzoic acid With 1-chloro-1-(dimethylamino)-2-methyl-1-propene In dichloromethane at 20℃; for 0.5h;
Stage #2: 2-chloro-6-fluoroaniline With pyridine In dichloromethane at 20℃; for 1h;
78%
3,3-dimethyl acrylaldehyde
107-86-8

3,3-dimethyl acrylaldehyde

2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

N-(2-chloro-6-fluorophenyl)-3-methylbut-2-en-1-imine

N-(2-chloro-6-fluorophenyl)-3-methylbut-2-en-1-imine

Conditions
ConditionsYield
With titanium tetrachloride; triethylamine In dichloromethane at 0 - 25℃; for 5h; Inert atmosphere;78%
With titanium tetrachloride; triethylamine In dichloromethane at 0 - 25℃; for 5h;
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

(S)-7-(3-((benzyloxy)methyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-6-fluoro-1-(pentan-2-yl)-1H-benzo[d][1,3]oxazine-2,4-dione

(S)-7-(3-((benzyloxy)methyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-6-fluoro-1-(pentan-2-yl)-1H-benzo[d][1,3]oxazine-2,4-dione

(S)-4-(3-((benzyloxy)methyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol- 1-yl)-N-(2-chloro-6-fluorophenyl)-5-fluoro-2-(pentan-2-ylamino)benzamide

(S)-4-(3-((benzyloxy)methyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol- 1-yl)-N-(2-chloro-6-fluorophenyl)-5-fluoro-2-(pentan-2-ylamino)benzamide

Conditions
ConditionsYield
Stage #1: 2-chloro-6-fluoroaniline With trimethylaluminium In toluene at 15℃; for 0.5h; Inert atmosphere;
Stage #2: (S)-7-(3-((benzyloxy)methyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-6-fluoro-1-(pentan-2-yl)-1H-benzo[d][1,3]oxazine-2,4-dione In toluene at 50℃; for 16h; Inert atmosphere;
77%
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

(5-methyl-2-oxo-cyclohexylidene)acetic acid ethyl ester
817621-74-2

(5-methyl-2-oxo-cyclohexylidene)acetic acid ethyl ester

1-(2-chloro-6-fluoro-phenyl)-5-methyl-1,4,5,6-tetrahydro-indol-2-one
817621-77-5

1-(2-chloro-6-fluoro-phenyl)-5-methyl-1,4,5,6-tetrahydro-indol-2-one

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 18h; Heating;76%
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

2,4-dichloropyrimidine-5-carbonyl chloride
2972-52-3

2,4-dichloropyrimidine-5-carbonyl chloride

2,4-dichloro-N-(2-chloro-6-fluorophenyl)pyrimidine-5-carboxamide

2,4-dichloro-N-(2-chloro-6-fluorophenyl)pyrimidine-5-carboxamide

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 15h; Inert atmosphere;75%
In tetrahydrofuran at 20℃; for 15h; Inert atmosphere;75%
3-methyl-2-pentenal
3592-19-6

3-methyl-2-pentenal

2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

6-(3-((benzyloxy)methyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-2-(2-chloro-6-fluorophenyl)-4-(3,3,3-trifluoroprop-1-en-2-yl)isoquinolin-1(2H)-one

6-(3-((benzyloxy)methyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-2-(2-chloro-6-fluorophenyl)-4-(3,3,3-trifluoroprop-1-en-2-yl)isoquinolin-1(2H)-one

Conditions
ConditionsYield
With titanium tetrachloride; triethylamine In dichloromethane at 0 - 20℃; for 5h; Inert atmosphere;70%
3-methyl-2-pentenal
3592-19-6

3-methyl-2-pentenal

2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

2-chloro-6-fluoro-N-(3-methylpent-2-en-1-ylidene)aniline

2-chloro-6-fluoro-N-(3-methylpent-2-en-1-ylidene)aniline

Conditions
ConditionsYield
With titanium tetrachloride In dichloromethane at 0 - 20℃; for 5h; Inert atmosphere;69.87%
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

trifluoroacetic acid
76-05-1

trifluoroacetic acid

N-(2-chloro-6-hydroxyphenyl)-2,2,2-trifluoroacetamide

N-(2-chloro-6-hydroxyphenyl)-2,2,2-trifluoroacetamide

Conditions
ConditionsYield
With Oxone In 1,4-dioxane at 90℃; Schlenk technique; Inert atmosphere; chemoselective reaction;65%
2-chloro-6-fluoroaniline
363-51-9

2-chloro-6-fluoroaniline

1-bromo-2,5-dimethoxy-3,4-dimethylbenzene
103323-61-1

1-bromo-2,5-dimethoxy-3,4-dimethylbenzene

1-fluoro-5,8-dimethoxy-6,7-dimethyl-9H-carbazole
1432270-58-0

1-fluoro-5,8-dimethoxy-6,7-dimethyl-9H-carbazole

Conditions
ConditionsYield
With palladium diacetate; sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate In toluene at 160℃; for 3h; Buchwald-Hartwig Coupling; Inert atmosphere; Microwave irradiation;62%

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