As a leading and professional manufacturer of APIs and API intermediates in China,Anhui Dexinjia Biopharm Co., Ltd founded in 2006, Except for the R&D center, our company has built a close cooperation relation with Chinese Academy of Sciences,
DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:37675-18-6
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
Cas:37675-18-6
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:37675-18-6
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:37675-18-6
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryEthyl (3S)-piperidine-3-carboxylate Basic information Product Name: Ethyl (3S)-piperidine-3-carboxylate Synonyms: (S)-(+)-ETHYL NIPECOTATE;(S)-ETHYL-NIPECOTATE;(S)-
Cas:37675-18-6
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:37675-18-6
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam
Cas:37675-18-6
Min.Order:1 Kilogram
FOB Price: $7.0 / 10.0
Type:Trading Company
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
Cas:37675-18-6
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:37675-18-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryEthyl (3S)-piperidine-3-carboxylate CAS:37675-18-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quali
Cas:37675-18-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Product Name: Ethyl (3S)-piperidine-3-carboxylate Synonyms: 3-Piperidinecarboxylicacid, ethyl ester, (S)-;(S)-(+)-ETHYL NIPECOTATE;(S)-ETHYL-NIPECOTATE;(S)-ETHYL PIPERIDINE-3-CARBOXYLATE;(S)-(+)-NIPECOTIC ACID ETHYL ESTER;(S)-NIPECOTIC ACID ETHY
Cas:37675-18-6
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
Cas:37675-18-6
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:37675-18-6
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:37675-18-6
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:37675-18-6
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:37675-18-6
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryIn stock (S)-Ethyl piperidine-3-carboxylate 37675-18-6Appearance:light yellow liquid Storage:room temperature Package:according to customers' requirements Application:Organic intermediates Transportation:By air(EMS or EUB or FedEx or TNT ect...) or b
Cas:37675-18-6
Min.Order:1 Gram
Negotiable
Type:Other
inquiry1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m
Cas:37675-18-6
Min.Order:1 Liter
FOB Price: $4.5 / 5.0
Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h
Cas:37675-18-6
Min.Order:0
Negotiable
Type:Other
inquiryProduct name: Ethyl (S)-Nipecotate CAS No.:37675-18-6 Molecule Formula:C8H15NO2 Molecule Weight:157.21 Purity: 99% Package: 25kg/drum Description:Colorless to yellowish liquid Manufacture Standards:Enterprise Standard TESTING ITE
Cas:37675-18-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developmen
Cas:37675-18-6
Min.Order:1 Kilogram
FOB Price: $2.0 / 6.0
Type:Trading Company
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:37675-18-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryEthyl (3S)-piperidine-3-carboxylate Basic information Product Name: Ethyl (3S)-piperidine-3-carboxylate Synonyms: (S)-(+)-ETHYL NIPECOTATE;(S)-ETHYL-NIPECOTATE;3-Piperidinecarboxylicacid, ethyl ester, (S)-;(3s)-(+)-ethyl Nipecotate;(S)-ETHYL P
Cas:37675-18-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:37675-18-6
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryWe Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
Cas:37675-18-6
Min.Order:0
Negotiable
Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:37675-18-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:37675-18-6
Min.Order:1 Metric Ton
FOB Price: $1.5
Type:Trading Company
inquiry(S)-(+)-nipecotic acid ethyl ester
Conditions | Yield |
---|---|
With sodium hydroxide In water at 0℃; | 89% |
With sodium hydroxide In water at 0℃; | 89% |
In water at 0℃; pH=13; Decomposition; | 65% |
With sodium hydroxide In water |
C4H6O6*C8H15NO2
(S)-(+)-nipecotic acid ethyl ester
Conditions | Yield |
---|---|
With sodium hydroxide In water | 89% |
Ethyl nipecotate
A
(R)-ethyl nipecotate
B
(S)-(+)-nipecotic acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: Ethyl nipecotate With L-Tartaric acid Stage #2: With potassium carbonate | A 20% B n/a |
With L-Tartaric acid In ethanol; acetone at 20℃; resolution; | |
With L-Tartaric acid In ethanol Resolution of racemate; optical yield given as %ee; | |
With L-Tartaric acid Resolution of racemate; |
Ethyl nipecotate
(S)-(+)-nipecotic acid ethyl ester
Conditions | Yield |
---|---|
With D-tartaric acid | |
Resolution of racemate; |
(3S)-Piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester
(S)-(+)-nipecotic acid ethyl ester
Conditions | Yield |
---|---|
With hydrogen; acetic acid; palladium on activated charcoal In ethanol for 3h; |
(4R)-3-({(3S)-1-[(benzyloxy)carbonyl]piperidin-3-yl}carbonyl)-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one
(S)-(+)-nipecotic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 85 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 4 h / 0 °C 2: rac. camphersulfonic acid / 15 h / Heating 3: H2; AcOH / Pd/C / ethanol / 3 h View Scheme |
5-bromovaleroyl chloride
(S)-(+)-nipecotic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: BuLi / tetrahydrofuran / 0.17 h / -30 °C 1.2: 87 percent / tetrahydrofuran / 2 h / 0 °C 2.1: TiCl4; Et3N / CH2Cl2 / 0.5 h / -15 °C 2.2: TiCl4 / CH2Cl2 / 3 h / 0 °C 3.1: 80 percent / NaH; Bu4NI / dimethylformamide / 3 h / 70 °C 4.1: 85 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 4 h / 0 °C 5.1: rac. camphersulfonic acid / 15 h / Heating 6.1: H2; AcOH / Pd/C / ethanol / 3 h View Scheme |
(3S)-1-phenylmethoxycarbonylpiperidine-3-carboxylic acid
(S)-(+)-nipecotic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: rac. camphersulfonic acid / 15 h / Heating 2: H2; AcOH / Pd/C / ethanol / 3 h View Scheme |
(4R)-3-(5-bromo-1-oxopentyl)-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one
(S)-(+)-nipecotic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: TiCl4; Et3N / CH2Cl2 / 0.5 h / -15 °C 1.2: TiCl4 / CH2Cl2 / 3 h / 0 °C 2.1: 80 percent / NaH; Bu4NI / dimethylformamide / 3 h / 70 °C 3.1: 85 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 4 h / 0 °C 4.1: rac. camphersulfonic acid / 15 h / Heating 5.1: H2; AcOH / Pd/C / ethanol / 3 h View Scheme |
(4R)-3-[(2S)-2-({[(benzyloxy)carbonyl]amino}methyl)-5-bromo-1-oxopentyl]-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one
(S)-(+)-nipecotic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 80 percent / NaH; Bu4NI / dimethylformamide / 3 h / 70 °C 2: 85 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 4 h / 0 °C 3: rac. camphersulfonic acid / 15 h / Heating 4: H2; AcOH / Pd/C / ethanol / 3 h View Scheme |
3-pyridinecarboxylic acid ethyl ester
(S)-(+)-nipecotic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Raney nickel; dioxane / 165 °C / 110326 - 220652 Torr / Hydrogenation 2: Dg-tartaric acid View Scheme |
(S)-(+)-nipecotic acid ethyl ester
Conditions | Yield |
---|---|
With sodium carbonate In diethyl ether at 20℃; for 2h; | 1.15 g |
ethanol
(S)-nipecotic acid
(S)-(+)-nipecotic acid ethyl ester
Conditions | Yield |
---|---|
With thionyl chloride at 100℃; for 6h; Inert atmosphere; |
chloroformic acid ethyl ester
(S)-(+)-nipecotic acid ethyl ester
ethyl N-carbethoxy-piperidine-3S-carboxylate
Conditions | Yield |
---|---|
With 4-methyl-morpholine In chloroform at 0 - 20℃; | 100% |
(S)-(+)-nipecotic acid ethyl ester
Conditions | Yield |
---|---|
With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 2h; | 99% |
acetic anhydride
(S)-(+)-nipecotic acid ethyl ester
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 24h; | 99% |
(S)-(+)-nipecotic acid ethyl ester
(S)-(hydroxymethyl)piperidine
Conditions | Yield |
---|---|
Stage #1: (S)-(+)-nipecotic acid ethyl ester With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 20℃; for 0.333333h; Heating / reflux; Stage #2: With sodium sulfate In tetrahydrofuran; diethyl ether; water | 98% |
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 20℃; for 2.33333h; Heating / reflux; | 98% |
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 20℃; for 2.33333h; Heating / reflux; | 98% |
Stage #1: (S)-(+)-nipecotic acid ethyl ester With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 3h; Stage #2: With potassium hydroxide In tetrahydrofuran; water at 0 - 20℃; for 15h; | |
With sodium tetrahydroborate; zinc(II) chloride In tetrahydrofuran at 50 - 66℃; for 4.5h; Inert atmosphere; |
isopentanoyl chloride
(S)-(+)-nipecotic acid ethyl ester
(S)-ethyl 1-(3-methylbutanoyl)piperidine-3-carboxylate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; for 6h; | 97.5% |
9-methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxylic acid
(S)-(+)-nipecotic acid ethyl ester
(3S)-ethyl 1-(9-methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carbonyl)piperidine-3-carboxylate
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 1h; | 97% |
2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole-5-sulfonyl chloride
(S)-(+)-nipecotic acid ethyl ester
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In 1,1-dichloroethane at 80℃; for 1h; | 96% |
With N-ethyl-N,N-diisopropylamine In 1,1-dichloroethane at 80℃; for 1h; | 96% |
(S)-(+)-nipecotic acid ethyl ester
(S)-2-(benzyloxycarbonylaminomethyl)-3-phenylpropanoic acid
Cbz-(S)β2hPhe-(S)β2hPro-OEt
Conditions | Yield |
---|---|
With 4-methyl-morpholine; HATU In dichloromethane at 0 - 25℃; | 95% |
(S)-(+)-nipecotic acid ethyl ester
Conditions | Yield |
---|---|
With hydrogenchloride In water; toluene at 60℃; Cooling; | 95% |
Multi-step reaction with 3 steps 1: 74 percent / CH2Cl2 / 16 h / 20 °C 2: 90 percent / LiOH / methanol; H2O / 72 h / 20 °C 3: HCl / 1.5 h / 110 °C View Scheme |
Conditions | Yield |
---|---|
In methanol at 0℃; for 6h; Reflux; | 93.4% |
4-[(4-chloro-2-(2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid
(S)-(+)-nipecotic acid ethyl ester
ethyl (3S)-1-(4-[(4-chloro-2-(2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h; | 92% |
N-(3,5-dichlorophenyl)picolinamide
(S)-(+)-nipecotic acid ethyl ester
Conditions | Yield |
---|---|
With [bis(acetoxy)iodo]benzene; copper(II) acetate monohydrate; magnesium chloride In 1,4-dioxane at 20℃; for 4h; Inert atmosphere; | 92% |
3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propionic acid
(S)-(+)-nipecotic acid ethyl ester
ethyl (3S)-1-(3-((4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)propanoyl)-3-piperidinecarboxylate
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; | 91% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 14.6h; |
4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)-methyl]-6-(3-hydroxypropoxy)phenyl)(2,2-dimethylpropyl)-amino]-4-oxobutanoic acid
(S)-(+)-nipecotic acid ethyl ester
ethyl (3S)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxypropoxy)phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h; | 88% |
2,6-Dichloropyrimidine
(S)-(+)-nipecotic acid ethyl ester
(S)-ethyl 1-(2-chloropyrimidin-4-yl)piperidine-3-carboxylate
Conditions | Yield |
---|---|
With triethylamine In ethanol at 0 - 23℃; for 18h; Inert atmosphere; | 88% |
formic acid
(S)-(+)-nipecotic acid ethyl ester
Conditions | Yield |
---|---|
In toluene for 4.5h; Reflux; Dean-Stark; | 88% |
Conditions | Yield |
---|---|
Stage #1: ethanol; (S)-(+)-nipecotic acid ethyl ester With potassium carbonate at 0℃; for 0.25h; Inert atmosphere; Stage #2: formaldehyd at 25℃; for 6h; Inert atmosphere; | 88% |
di-tert-butyl dicarbonate
(S)-(+)-nipecotic acid ethyl ester
ethyl (S)-1-[(tert-butoxy)carbonyl]piperidine-3-carboxylate
Conditions | Yield |
---|---|
In dichloromethane | 87% |
With triethylamine In dichloromethane at 20℃; for 3h; | 87% |
With triethylamine In dichloromethane at 20℃; for 3h; | 87% |
(3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid
(S)-(+)-nipecotic acid ethyl ester
Boc-(S)-β2-HPro-(S)-β2-HPro-OEt
Conditions | Yield |
---|---|
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In chloroform at 0℃; for 16h; Acylation; peptide coupling; | 87% |
4-[(4-chloro-2-(3-hydroxy-2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid
(S)-(+)-nipecotic acid ethyl ester
ethyl (3S)-1-(4-[(4-chloro-2-(3-hydroxy-2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h; | 87% |
3-chloro-2-methylbenzoic acid
(S)-(+)-nipecotic acid ethyl ester
(S)-ethyl 1-(3-chloro-2-methylbenzoyl)piperidine-3-carboxylate
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Inert atmosphere; | 86% |
(S)-(+)-nipecotic acid ethyl ester
tert-butyl 2-(3-bromophenoxy)-2-methylpropanoate
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; ruphos In toluene at 80℃; | 82% |
4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)-methyl]-6-(3-hydroxy-3-methylbutoxy)phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid
(S)-(+)-nipecotic acid ethyl ester
ethyl (3S)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxy-3-methylbutoxy)phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h; | 81% |
2-bromo-4-fluoro-pyridine
(S)-(+)-nipecotic acid ethyl ester
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide at 100℃; | 81% |
With potassium carbonate In dimethyl sulfoxide at 100℃; | 81% |
(S)-(+)-2-(4-cyanophenyl)oxirane
(S)-(+)-nipecotic acid ethyl ester
ethyl (3S)-1-[(2S)-2-(4-cyanophenyl)-2-hydroxyethyl]piperidine-3-carboxylate
Conditions | Yield |
---|---|
With dmap In isopropyl alcohol at 50℃; Inert atmosphere; stereospecific reaction; | 80% |
Stage #1: (S)-(+)-2-(4-cyanophenyl)oxirane; (S)-(+)-nipecotic acid ethyl ester In isopropyl alcohol at 55℃; for 4h; Inert atmosphere; Stage #2: With dmap In isopropyl alcohol at 50℃; for 12h; | 72% |
4-(3-methyl-2-thienyl)-4-(2-thienyl)-3-butenyl 4-methylbenzenesulfonate
(S)-(+)-nipecotic acid ethyl ester
ethyl (S)-1-<4-(3-methyl-2-thienyl)-4-(2-thienyl)-3-butenyl>-3-piperidinecarboxylate
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In acetone for 44h; Ambient temperature; | 79% |
4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-methoxyphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid
(S)-(+)-nipecotic acid ethyl ester
ethyl (3S)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-methoxyphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h; | 74% |
4-[(4-chloro-2-ethoxy-6-[(S)-hydroxy(2-methoxyphenyl)-methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid
(S)-(+)-nipecotic acid ethyl ester
A
ethyl (3S)-1-(4-[(4-chloro-2-ethoxy-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate
B
ethyl (3S)-1-(4-[(4-chloro-2-ethoxy-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h; | A 7% B 74% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View