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Anhui Dexinjia Biopharm Co., Ltd

As a leading and professional manufacturer of APIs and API intermediates in China,Anhui Dexinjia Biopharm Co., Ltd founded in 2006, Except for the R&D center, our company has built a close cooperation relation with Chinese Academy of Sciences,

Ethyl (S)-nipecotate

Cas:37675-18-6

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Ethyl (3S)-piperidine-3-carboxylate Manufacturer/High quality/Best price/In stock

Cas:37675-18-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Ethyl (S)-(+)-3-Piperidinecarboxylate

Cas:37675-18-6

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Ethyl (3S)-piperidine-3-carboxylate

Cas:37675-18-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(S)-(+)-Ethyl nipecotate

Cas:37675-18-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Ethyl (3S)-piperidine-3-carboxylate Basic information Product Name: Ethyl (3S)-piperidine-3-carboxylate Synonyms: (S)-(+)-ETHYL NIPECOTATE;(S)-ETHYL-NIPECOTATE;(S)-

Ethyl (3S)-piperidine-3-carboxylate

Cas:37675-18-6

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 37675-18-6 with competitive price

Cas:37675-18-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam

Ethyl (3S)-piperidine-3-carboxylate CAS37675-18-6

Cas:37675-18-6

Min.Order:1 Kilogram

FOB Price: $7.0 / 10.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

(S)-Ethyl piperidine-3-carboxylate CAS NO. 37675-18-6 CAS NO.37675-18-6

Cas:37675-18-6

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ethyl (3S)-piperidine-3-carboxylate 37675-18-6

Cas:37675-18-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Ethyl (3S)-piperidine-3-carboxylate CAS:37675-18-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quali

Ethyl (3S)-piperidine-3-carboxylate CAS:37675-18-6

Cas:37675-18-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:37675-18-6

Cas:37675-18-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Ethyl (3S)-piperidine-3-carboxylate Synonyms: 3-Piperidinecarboxylicacid, ethyl ester, (S)-;(S)-(+)-ETHYL NIPECOTATE;(S)-ETHYL-NIPECOTATE;(S)-ETHYL PIPERIDINE-3-CARBOXYLATE;(S)-(+)-NIPECOTIC ACID ETHYL ESTER;(S)-NIPECOTIC ACID ETHY

Ethyl (3S)-piperidine-3-carboxylate supplier best quality

Cas:37675-18-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

(S)-Ethyl piperidine-3-carboxylate

Cas:37675-18-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Ethyl (S)-nipecotate

Cas:37675-18-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Ethyl (S)-nipecotate

Cas:37675-18-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(S)-Piperidine-3-Carboxylic Acid EthylEster

Cas:37675-18-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethyl (3S)-piperidine-3-carboxylate

Cas:37675-18-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Ethyl (3S)-piperidine-3-carboxylate

Cas:37675-18-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

In stock (S)-Ethyl piperidine-3-carboxylate 37675-18-6Appearance:light yellow liquid Storage:room temperature Package:according to customers' requirements Application:Organic intermediates Transportation:By air(EMS or EUB or FedEx or TNT ect...) or b

In stock (S)-Ethyl piperidine-3-carboxylate 37675-18-6

Cas:37675-18-6

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hebei Kunsui Technology Co., Ltd.

1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m

Organic Intermediate Ethyl (3S)-piperidine-3-carboxylate CAS 37675-18-6

Cas:37675-18-6

Min.Order:1 Liter

FOB Price: $4.5 / 5.0

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply Ethyl (3S)-piperidine-3-carboxylate

Cas:37675-18-6

Min.Order:0

Negotiable

Type:Other

inquiry

Siwei Development Group Ltd.

Product name: Ethyl (S)-Nipecotate CAS No.:37675-18-6 Molecule Formula:C8H15NO2 Molecule Weight:157.21 Purity: 99% Package: 25kg/drum Description:Colorless to yellowish liquid Manufacture Standards:Enterprise Standard TESTING ITE

High Quality Ethyl (S)-Nipecotate in stock

Cas:37675-18-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developmen

(S)-Ethyl piperidine-3-carboxylate CAS NO.37675-18-6

Cas:37675-18-6

Min.Order:1 Kilogram

FOB Price: $2.0 / 6.0

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Ethyl (3S)-piperidine-3-carboxylate

Cas:37675-18-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Ethyl (3S)-piperidine-3-carboxylate Basic information Product Name: Ethyl (3S)-piperidine-3-carboxylate Synonyms: (S)-(+)-ETHYL NIPECOTATE;(S)-ETHYL-NIPECOTATE;3-Piperidinecarboxylicacid, ethyl ester, (S)-;(3s)-(+)-ethyl Nipecotate;(S)-ETHYL P

Ethyl (3S)-piperidine-3-carboxylate

Cas:37675-18-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Ethyl (S)-nipecotate

Cas:37675-18-6

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

Ethyl (3S)-piperidine-3-carboxylate

Cas:37675-18-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Ethyl (3S)-piperidine-3-carboxylate

Cas:37675-18-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Ethyl (S)-nipecotate

Cas:37675-18-6

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Synthetic route

(S)-ethyl nipecotate (S,S)-hydrogen tartrate

(S)-ethyl nipecotate (S,S)-hydrogen tartrate

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

Conditions
ConditionsYield
With sodium hydroxide In water at 0℃;89%
With sodium hydroxide In water at 0℃;89%
In water at 0℃; pH=13; Decomposition;65%
With sodium hydroxide In water
C4H6O6*C8H15NO2
183316-65-6

C4H6O6*C8H15NO2

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

Conditions
ConditionsYield
With sodium hydroxide In water89%
Ethyl nipecotate
71962-74-8

Ethyl nipecotate

A

(R)-ethyl nipecotate
25137-01-3

(R)-ethyl nipecotate

B

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

Conditions
ConditionsYield
Stage #1: Ethyl nipecotate With L-Tartaric acid
Stage #2: With potassium carbonate
A 20%
B n/a
With L-Tartaric acid In ethanol; acetone at 20℃; resolution;
With L-Tartaric acid In ethanol Resolution of racemate; optical yield given as %ee;
With L-Tartaric acid Resolution of racemate;
Ethyl nipecotate
71962-74-8

Ethyl nipecotate

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

Conditions
ConditionsYield
With D-tartaric acid
Resolution of racemate;
(3S)-Piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester
174699-11-7

(3S)-Piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

Conditions
ConditionsYield
With hydrogen; acetic acid; palladium on activated charcoal In ethanol for 3h;
(4R)-3-({(3S)-1-[(benzyloxy)carbonyl]piperidin-3-yl}carbonyl)-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one
868632-22-8

(4R)-3-({(3S)-1-[(benzyloxy)carbonyl]piperidin-3-yl}carbonyl)-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 85 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 4 h / 0 °C
2: rac. camphersulfonic acid / 15 h / Heating
3: H2; AcOH / Pd/C / ethanol / 3 h
View Scheme
5-bromovaleroyl chloride
4509-90-4

5-bromovaleroyl chloride

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: BuLi / tetrahydrofuran / 0.17 h / -30 °C
1.2: 87 percent / tetrahydrofuran / 2 h / 0 °C
2.1: TiCl4; Et3N / CH2Cl2 / 0.5 h / -15 °C
2.2: TiCl4 / CH2Cl2 / 3 h / 0 °C
3.1: 80 percent / NaH; Bu4NI / dimethylformamide / 3 h / 70 °C
4.1: 85 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 4 h / 0 °C
5.1: rac. camphersulfonic acid / 15 h / Heating
6.1: H2; AcOH / Pd/C / ethanol / 3 h
View Scheme
(3S)-1-phenylmethoxycarbonylpiperidine-3-carboxylic acid
88466-74-4

(3S)-1-phenylmethoxycarbonylpiperidine-3-carboxylic acid

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: rac. camphersulfonic acid / 15 h / Heating
2: H2; AcOH / Pd/C / ethanol / 3 h
View Scheme
(4R)-3-(5-bromo-1-oxopentyl)-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one
637337-43-0

(4R)-3-(5-bromo-1-oxopentyl)-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: TiCl4; Et3N / CH2Cl2 / 0.5 h / -15 °C
1.2: TiCl4 / CH2Cl2 / 3 h / 0 °C
2.1: 80 percent / NaH; Bu4NI / dimethylformamide / 3 h / 70 °C
3.1: 85 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 4 h / 0 °C
4.1: rac. camphersulfonic acid / 15 h / Heating
5.1: H2; AcOH / Pd/C / ethanol / 3 h
View Scheme
(4R)-3-[(2S)-2-({[(benzyloxy)carbonyl]amino}methyl)-5-bromo-1-oxopentyl]-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one
637337-59-8

(4R)-3-[(2S)-2-({[(benzyloxy)carbonyl]amino}methyl)-5-bromo-1-oxopentyl]-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 80 percent / NaH; Bu4NI / dimethylformamide / 3 h / 70 °C
2: 85 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 4 h / 0 °C
3: rac. camphersulfonic acid / 15 h / Heating
4: H2; AcOH / Pd/C / ethanol / 3 h
View Scheme
3-pyridinecarboxylic acid ethyl ester
614-18-6

3-pyridinecarboxylic acid ethyl ester

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Raney nickel; dioxane / 165 °C / 110326 - 220652 Torr / Hydrogenation
2: Dg-tartaric acid
View Scheme
salt of (D)-2-(4-hydroxyphenoxy)propionic acid with ethyl 3-piperidinecarboxylate

salt of (D)-2-(4-hydroxyphenoxy)propionic acid with ethyl 3-piperidinecarboxylate

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

Conditions
ConditionsYield
With sodium carbonate In diethyl ether at 20℃; for 2h;1.15 g
ethanol
64-17-5

ethanol

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

Conditions
ConditionsYield
With thionyl chloride at 100℃; for 6h; Inert atmosphere;
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

ethyl N-carbethoxy-piperidine-3S-carboxylate
1346514-04-2

ethyl N-carbethoxy-piperidine-3S-carboxylate

Conditions
ConditionsYield
With 4-methyl-morpholine In chloroform at 0 - 20℃;100%
(R)-2-fluoro-4-(1-hydroxybutyl)benzoic acid

(R)-2-fluoro-4-(1-hydroxybutyl)benzoic acid

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

(S)-1-(2-fluoro-4-((1R)-1-hydroxybutyl)benzoyl)piperidine-3-carboxylic acid ethyl ester

(S)-1-(2-fluoro-4-((1R)-1-hydroxybutyl)benzoyl)piperidine-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 2h;99%
acetic anhydride
108-24-7

acetic anhydride

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

(S)-nipecotic acid ethyl ester

(S)-nipecotic acid ethyl ester

Conditions
ConditionsYield
In dichloromethane at 20℃; for 24h;99%
(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

Conditions
ConditionsYield
Stage #1: (S)-(+)-nipecotic acid ethyl ester With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 20℃; for 0.333333h; Heating / reflux;
Stage #2: With sodium sulfate In tetrahydrofuran; diethyl ether; water
98%
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 20℃; for 2.33333h; Heating / reflux;98%
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 20℃; for 2.33333h; Heating / reflux;98%
Stage #1: (S)-(+)-nipecotic acid ethyl ester With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 3h;
Stage #2: With potassium hydroxide In tetrahydrofuran; water at 0 - 20℃; for 15h;
With sodium tetrahydroborate; zinc(II) chloride In tetrahydrofuran at 50 - 66℃; for 4.5h; Inert atmosphere;
isopentanoyl chloride
108-12-3

isopentanoyl chloride

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

(S)-ethyl 1-(3-methylbutanoyl)piperidine-3-carboxylate
1554631-89-8

(S)-ethyl 1-(3-methylbutanoyl)piperidine-3-carboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 6h;97.5%
9-methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxylic acid
1121526-82-6

9-methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxylic acid

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

(3S)-ethyl 1-(9-methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carbonyl)piperidine-3-carboxylate
1121527-59-0

(3S)-ethyl 1-(9-methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carbonyl)piperidine-3-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 1h;97%
2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole-5-sulfonyl chloride
952674-99-6

2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole-5-sulfonyl chloride

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

ethyl (3S)-1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)piperidine-3-carboxylate

ethyl (3S)-1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)piperidine-3-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In 1,1-dichloroethane at 80℃; for 1h;96%
With N-ethyl-N,N-diisopropylamine In 1,1-dichloroethane at 80℃; for 1h;96%
(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

(S)-2-(benzyloxycarbonylaminomethyl)-3-phenylpropanoic acid
261174-46-3

(S)-2-(benzyloxycarbonylaminomethyl)-3-phenylpropanoic acid

Cbz-(S)β2hPhe-(S)β2hPro-OEt
764704-88-3

Cbz-(S)β2hPhe-(S)β2hPro-OEt

Conditions
ConditionsYield
With 4-methyl-morpholine; HATU In dichloromethane at 0 - 25℃;95%
(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

(S)-piperidine-3-carboxylic acid ethyl ester hydrochloride

(S)-piperidine-3-carboxylic acid ethyl ester hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water; toluene at 60℃; Cooling;95%
Multi-step reaction with 3 steps
1: 74 percent / CH2Cl2 / 16 h / 20 °C
2: 90 percent / LiOH / methanol; H2O / 72 h / 20 °C
3: HCl / 1.5 h / 110 °C
View Scheme
formic acid
64-18-6

formic acid

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

C9H17NO2

C9H17NO2

Conditions
ConditionsYield
In methanol at 0℃; for 6h; Reflux;93.4%
4-[(4-chloro-2-(2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid
922161-60-2

4-[(4-chloro-2-(2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

ethyl (3S)-1-(4-[(4-chloro-2-(2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate
922161-61-3

ethyl (3S)-1-(4-[(4-chloro-2-(2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h;92%
N-(3,5-dichlorophenyl)picolinamide
879824-11-0

N-(3,5-dichlorophenyl)picolinamide

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

C20H21Cl2N3O3

C20H21Cl2N3O3

Conditions
ConditionsYield
With [bis(acetoxy)iodo]benzene; copper(II) acetate monohydrate; magnesium chloride In 1,4-dioxane at 20℃; for 4h; Inert atmosphere;92%
3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propionic acid
937054-53-0

3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propionic acid

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

ethyl (3S)-1-(3-((4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)propanoyl)-3-piperidinecarboxylate
937055-14-6

ethyl (3S)-1-(3-((4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)propanoyl)-3-piperidinecarboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;91%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 14.6h;
4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)-methyl]-6-(3-hydroxypropoxy)phenyl)(2,2-dimethylpropyl)-amino]-4-oxobutanoic acid
922161-64-6

4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)-methyl]-6-(3-hydroxypropoxy)phenyl)(2,2-dimethylpropyl)-amino]-4-oxobutanoic acid

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

ethyl (3S)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxypropoxy)phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate
1334531-23-5

ethyl (3S)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxypropoxy)phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h;88%
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

(S)-ethyl 1-(2-chloropyrimidin-4-yl)piperidine-3-carboxylate
1347758-03-5

(S)-ethyl 1-(2-chloropyrimidin-4-yl)piperidine-3-carboxylate

Conditions
ConditionsYield
With triethylamine In ethanol at 0 - 23℃; for 18h; Inert atmosphere;88%
formic acid
64-18-6

formic acid

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

ethyl (3S)-1-formylpiperidine-3-carboxylate

ethyl (3S)-1-formylpiperidine-3-carboxylate

Conditions
ConditionsYield
In toluene for 4.5h; Reflux; Dean-Stark;88%
formaldehyd
50-00-0

formaldehyd

ethanol
64-17-5

ethanol

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

ethyl 1-(ethoxymethyl)piperidine-3-carboxylate

ethyl 1-(ethoxymethyl)piperidine-3-carboxylate

Conditions
ConditionsYield
Stage #1: ethanol; (S)-(+)-nipecotic acid ethyl ester With potassium carbonate at 0℃; for 0.25h; Inert atmosphere;
Stage #2: formaldehyd at 25℃; for 6h; Inert atmosphere;
88%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

ethyl (S)-1-[(tert-butoxy)carbonyl]piperidine-3-carboxylate
191599-51-6

ethyl (S)-1-[(tert-butoxy)carbonyl]piperidine-3-carboxylate

Conditions
ConditionsYield
In dichloromethane87%
With triethylamine In dichloromethane at 20℃; for 3h;87%
With triethylamine In dichloromethane at 20℃; for 3h;87%
(3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid
88495-54-9

(3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

Boc-(S)-β2-HPro-(S)-β2-HPro-OEt
253790-54-4

Boc-(S)-β2-HPro-(S)-β2-HPro-OEt

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In chloroform at 0℃; for 16h; Acylation; peptide coupling;87%
4-[(4-chloro-2-(3-hydroxy-2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid
922161-76-0

4-[(4-chloro-2-(3-hydroxy-2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

ethyl (3S)-1-(4-[(4-chloro-2-(3-hydroxy-2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate
922161-77-1

ethyl (3S)-1-(4-[(4-chloro-2-(3-hydroxy-2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h;87%
3-chloro-2-methylbenzoic acid
7499-08-3

3-chloro-2-methylbenzoic acid

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

(S)-ethyl 1-(3-chloro-2-methylbenzoyl)piperidine-3-carboxylate
1430424-36-4

(S)-ethyl 1-(3-chloro-2-methylbenzoyl)piperidine-3-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Inert atmosphere;86%
(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

tert-butyl 2-(3-bromophenoxy)-2-methylpropanoate
393186-07-7

tert-butyl 2-(3-bromophenoxy)-2-methylpropanoate

ethyl (S)-1-(3-((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)phenyl)piperidine-3-carboxylate

ethyl (S)-1-(3-((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)phenyl)piperidine-3-carboxylate

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; ruphos In toluene at 80℃;82%
4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)-methyl]-6-(3-hydroxy-3-methylbutoxy)phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid
922161-82-8

4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)-methyl]-6-(3-hydroxy-3-methylbutoxy)phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

ethyl (3S)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxy-3-methylbutoxy)phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate
922161-83-9

ethyl (3S)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxy-3-methylbutoxy)phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h;81%
2-bromo-4-fluoro-pyridine
357927-50-5

2-bromo-4-fluoro-pyridine

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

(S)-ethyl 1-(2-bromopyridin-4-yl)piperidine-3-carboxylate

(S)-ethyl 1-(2-bromopyridin-4-yl)piperidine-3-carboxylate

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 100℃;81%
With potassium carbonate In dimethyl sulfoxide at 100℃;81%
(S)-(+)-2-(4-cyanophenyl)oxirane
179694-33-8

(S)-(+)-2-(4-cyanophenyl)oxirane

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

ethyl (3S)-1-[(2S)-2-(4-cyanophenyl)-2-hydroxyethyl]piperidine-3-carboxylate
1265323-48-5

ethyl (3S)-1-[(2S)-2-(4-cyanophenyl)-2-hydroxyethyl]piperidine-3-carboxylate

Conditions
ConditionsYield
With dmap In isopropyl alcohol at 50℃; Inert atmosphere; stereospecific reaction;80%
Stage #1: (S)-(+)-2-(4-cyanophenyl)oxirane; (S)-(+)-nipecotic acid ethyl ester In isopropyl alcohol at 55℃; for 4h; Inert atmosphere;
Stage #2: With dmap In isopropyl alcohol at 50℃; for 12h;
72%
4-(3-methyl-2-thienyl)-4-(2-thienyl)-3-butenyl 4-methylbenzenesulfonate
148319-31-7

4-(3-methyl-2-thienyl)-4-(2-thienyl)-3-butenyl 4-methylbenzenesulfonate

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

ethyl (S)-1-<4-(3-methyl-2-thienyl)-4-(2-thienyl)-3-butenyl>-3-piperidinecarboxylate
148319-28-2

ethyl (S)-1-<4-(3-methyl-2-thienyl)-4-(2-thienyl)-3-butenyl>-3-piperidinecarboxylate

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetone for 44h; Ambient temperature;79%
4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-methoxyphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid
922160-87-0

4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-methoxyphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

ethyl (3S)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-methoxyphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate
922160-92-7

ethyl (3S)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-methoxyphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h;74%
4-[(4-chloro-2-ethoxy-6-[(S)-hydroxy(2-methoxyphenyl)-methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid
922161-43-1

4-[(4-chloro-2-ethoxy-6-[(S)-hydroxy(2-methoxyphenyl)-methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid

(S)-(+)-nipecotic acid ethyl ester
37675-18-6

(S)-(+)-nipecotic acid ethyl ester

A

ethyl (3S)-1-(4-[(4-chloro-2-ethoxy-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate
922161-44-2

ethyl (3S)-1-(4-[(4-chloro-2-ethoxy-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate

B

ethyl (3S)-1-(4-[(4-chloro-2-ethoxy-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate
922161-44-2

ethyl (3S)-1-(4-[(4-chloro-2-ethoxy-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h;A 7%
B 74%

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