Ethyl (3S)-piperidine-3-carboxylate supplier

Name
Ethyl (3S)-piperidine-3-carboxylate
EINECS 609-464-4
CAS No. 37675-18-6
Article Data16
CAS DataBase
Density 1.003 g/cm³
Solubility
Melting Point
Formula C₈H₁₅NO₂
Boiling Point 238.6 °C at 760 mmHg
Molecular Weight 157.213
Flash Point 90.6 °C
Transport Information
Appearance liquid
Safety 26-36/37/39-39-36
Risk Codes 36/37/38-41
Molecular Structure
Hazard Symbols Xi
Synonyms 3-Piperidinecarboxylicacid, ethyl ester, (S)-;(+)-Ethyl nipecotate;(S)-(+)-Ethyl nipecotate;(S)-Ethyl nipecotate;Ethyl(S)-3-piperidinecarboxylate;Ethyl (S)-nipecotate;3-Piperidinecarboxylicacid, ethyl ester, (3S)-;
PSA 38.33000
LogP 0.87790

Synthetic route

: (S)-ethyl nipecotate (S,S)-hydrogen tartrate

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

Conditions

Conditions	Yield
With sodium hydroxide In water at 0℃;	89%
With sodium hydroxide In water at 0℃;	89%
In water at 0℃; pH=13; Decomposition;	65%
With sodium hydroxide In water

: 183316-65-6
C4H6O6*C8H15NO2

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

Conditions

Conditions	Yield
With sodium hydroxide In water	89%

: 71962-74-8
Ethyl nipecotate

A: 25137-01-3
(R)-ethyl nipecotate

B: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: Ethyl nipecotate With L-Tartaric acid Stage #2: With potassium carbonate	A 20% B n/a
With L-Tartaric acid In ethanol; acetone at 20℃; resolution;
With L-Tartaric acid In ethanol Resolution of racemate; optical yield given as %ee;
With L-Tartaric acid Resolution of racemate;

: 71962-74-8
Ethyl nipecotate

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

Conditions

Conditions	Yield
With D-tartaric acid
Resolution of racemate;

: 174699-11-7
(3S)-Piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-ethyl ester

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

Conditions

Conditions	Yield
With hydrogen; acetic acid; palladium on activated charcoal In ethanol for 3h;

: 868632-22-8
(4R)-3-({(3S)-1-[(benzyloxy)carbonyl]piperidin-3-yl}carbonyl)-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 85 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 4 h / 0 °C 2: rac. camphersulfonic acid / 15 h / Heating 3: H2; AcOH / Pd/C / ethanol / 3 h View Scheme

: 4509-90-4
5-bromovaleroyl chloride

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: BuLi / tetrahydrofuran / 0.17 h / -30 °C 1.2: 87 percent / tetrahydrofuran / 2 h / 0 °C 2.1: TiCl4; Et3N / CH2Cl2 / 0.5 h / -15 °C 2.2: TiCl4 / CH2Cl2 / 3 h / 0 °C 3.1: 80 percent / NaH; Bu4NI / dimethylformamide / 3 h / 70 °C 4.1: 85 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 4 h / 0 °C 5.1: rac. camphersulfonic acid / 15 h / Heating 6.1: H2; AcOH / Pd/C / ethanol / 3 h View Scheme

Yield

Multi-step reaction with 6 steps
1.1: BuLi / tetrahydrofuran / 0.17 h / -30 °C
1.2: 87 percent / tetrahydrofuran / 2 h / 0 °C
2.1: TiCl4; Et3N / CH2Cl2 / 0.5 h / -15 °C
2.2: TiCl4 / CH2Cl2 / 3 h / 0 °C
3.1: 80 percent / NaH; Bu4NI / dimethylformamide / 3 h / 70 °C
4.1: 85 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 4 h / 0 °C
5.1: rac. camphersulfonic acid / 15 h / Heating
6.1: H2; AcOH / Pd/C / ethanol / 3 h
View Scheme

: 88466-74-4
(3S)-1-phenylmethoxycarbonylpiperidine-3-carboxylic acid

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: rac. camphersulfonic acid / 15 h / Heating 2: H2; AcOH / Pd/C / ethanol / 3 h View Scheme

: 637337-43-0
(4R)-3-(5-bromo-1-oxopentyl)-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: TiCl4; Et3N / CH2Cl2 / 0.5 h / -15 °C 1.2: TiCl4 / CH2Cl2 / 3 h / 0 °C 2.1: 80 percent / NaH; Bu4NI / dimethylformamide / 3 h / 70 °C 3.1: 85 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 4 h / 0 °C 4.1: rac. camphersulfonic acid / 15 h / Heating 5.1: H2; AcOH / Pd/C / ethanol / 3 h View Scheme

: 637337-59-8
(4R)-3-[(2S)-2-({[(benzyloxy)carbonyl]amino}methyl)-5-bromo-1-oxopentyl]-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 80 percent / NaH; Bu4NI / dimethylformamide / 3 h / 70 °C 2: 85 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 4 h / 0 °C 3: rac. camphersulfonic acid / 15 h / Heating 4: H2; AcOH / Pd/C / ethanol / 3 h View Scheme

: 614-18-6
3-pyridinecarboxylic acid ethyl ester

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Raney nickel; dioxane / 165 °C / 110326 - 220652 Torr / Hydrogenation 2: Dg-tartaric acid View Scheme

: salt of (D)-2-(4-hydroxyphenoxy)propionic acid with ethyl 3-piperidinecarboxylate

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

Conditions

Conditions	Yield
With sodium carbonate In diethyl ether at 20℃; for 2h;	1.15 g

: 64-17-5
ethanol

: 498-95-3, 25137-00-2, 59045-82-8, 60252-41-7
(S)-nipecotic acid

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

Conditions

Conditions	Yield
With thionyl chloride at 100℃; for 6h; Inert atmosphere;

: 541-41-3
chloroformic acid ethyl ester

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 1346514-04-2
ethyl N-carbethoxy-piperidine-3S-carboxylate

Conditions

Conditions	Yield
With 4-methyl-morpholine In chloroform at 0 - 20℃;	100%

: (R)-2-fluoro-4-(1-hydroxybutyl)benzoic acid

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: (S)-1-(2-fluoro-4-((1R)-1-hydroxybutyl)benzoyl)piperidine-3-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 2h;	99%

: 108-24-7
acetic anhydride

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: (S)-nipecotic acid ethyl ester

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 24h;	99%

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 4606-65-9, 37675-20-0, 136982-27-9, 144539-77-5
(S)-(hydroxymethyl)piperidine

Conditions

Conditions	Yield
Stage #1: (S)-(+)-nipecotic acid ethyl ester With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 20℃; for 0.333333h; Heating / reflux; Stage #2: With sodium sulfate In tetrahydrofuran; diethyl ether; water	98%
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 20℃; for 2.33333h; Heating / reflux;	98%
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 20℃; for 2.33333h; Heating / reflux;	98%
Stage #1: (S)-(+)-nipecotic acid ethyl ester With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 3h; Stage #2: With potassium hydroxide In tetrahydrofuran; water at 0 - 20℃; for 15h;
With sodium tetrahydroborate; zinc(II) chloride In tetrahydrofuran at 50 - 66℃; for 4.5h; Inert atmosphere;

: 108-12-3
isopentanoyl chloride

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 1554631-89-8
(S)-ethyl 1-(3-methylbutanoyl)piperidine-3-carboxylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 6h;	97.5%

: 1121526-82-6
9-methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxylic acid

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 1121527-59-0
(3S)-ethyl 1-(9-methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carbonyl)piperidine-3-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 1h;	97%

: 952674-99-6
2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole-5-sulfonyl chloride

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: ethyl (3S)-1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)piperidine-3-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In 1,1-dichloroethane at 80℃; for 1h;	96%
With N-ethyl-N,N-diisopropylamine In 1,1-dichloroethane at 80℃; for 1h;	96%

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 261174-46-3
(S)-2-(benzyloxycarbonylaminomethyl)-3-phenylpropanoic acid

: 764704-88-3
Cbz-(S)β2hPhe-(S)β2hPro-OEt

Conditions

Conditions	Yield
With 4-methyl-morpholine; HATU In dichloromethane at 0 - 25℃;	95%

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: (S)-piperidine-3-carboxylic acid ethyl ester hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water; toluene at 60℃; Cooling;	95%
Multi-step reaction with 3 steps 1: 74 percent / CH2Cl2 / 16 h / 20 °C 2: 90 percent / LiOH / methanol; H2O / 72 h / 20 °C 3: HCl / 1.5 h / 110 °C View Scheme

: 64-18-6
formic acid

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: C9H17NO2

Conditions

Conditions	Yield
In methanol at 0℃; for 6h; Reflux;	93.4%

: 922161-60-2
4-[(4-chloro-2-(2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 922161-61-3
ethyl (3S)-1-(4-[(4-chloro-2-(2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h;	92%

: 879824-11-0
N-(3,5-dichlorophenyl)picolinamide

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: C20H21Cl2N3O3

Conditions

Conditions	Yield
With [bis(acetoxy)iodo]benzene; copper(II) acetate monohydrate; magnesium chloride In 1,4-dioxane at 20℃; for 4h; Inert atmosphere;	92%

: 937054-53-0
3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propionic acid

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 937055-14-6
ethyl (3S)-1-(3-((4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)propanoyl)-3-piperidinecarboxylate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	91%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 14.6h;

: 922161-64-6
4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)-methyl]-6-(3-hydroxypropoxy)phenyl)(2,2-dimethylpropyl)-amino]-4-oxobutanoic acid

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 1334531-23-5
ethyl (3S)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxypropoxy)phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h;	88%

: 3934-20-1
2,6-Dichloropyrimidine

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 1347758-03-5
(S)-ethyl 1-(2-chloropyrimidin-4-yl)piperidine-3-carboxylate

Conditions

Conditions	Yield
With triethylamine In ethanol at 0 - 23℃; for 18h; Inert atmosphere;	88%

: 64-18-6
formic acid

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: ethyl (3S)-1-formylpiperidine-3-carboxylate

Conditions

Conditions	Yield
In toluene for 4.5h; Reflux; Dean-Stark;	88%

: 50-00-0
formaldehyd

: 64-17-5
ethanol

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: ethyl 1-(ethoxymethyl)piperidine-3-carboxylate

Conditions

Conditions	Yield
Stage #1: ethanol; (S)-(+)-nipecotic acid ethyl ester With potassium carbonate at 0℃; for 0.25h; Inert atmosphere; Stage #2: formaldehyd at 25℃; for 6h; Inert atmosphere;	88%

...Expand

: 24424-99-5
di-tert-butyl dicarbonate

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 191599-51-6
ethyl (S)-1-[(tert-butoxy)carbonyl]piperidine-3-carboxylate

Conditions

Conditions	Yield
In dichloromethane	87%
With triethylamine In dichloromethane at 20℃; for 3h;	87%
With triethylamine In dichloromethane at 20℃; for 3h;	87%

: 88495-54-9
(3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 253790-54-4
Boc-(S)-β2-HPro-(S)-β2-HPro-OEt

Conditions

Conditions	Yield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In chloroform at 0℃; for 16h; Acylation; peptide coupling;	87%

: 922161-76-0
4-[(4-chloro-2-(3-hydroxy-2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 922161-77-1
ethyl (3S)-1-(4-[(4-chloro-2-(3-hydroxy-2,2-dimethylpropoxy)-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h;	87%

: 7499-08-3
3-chloro-2-methylbenzoic acid

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 1430424-36-4
(S)-ethyl 1-(3-chloro-2-methylbenzoyl)piperidine-3-carboxylate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Inert atmosphere;	86%

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 393186-07-7
tert-butyl 2-(3-bromophenoxy)-2-methylpropanoate

: ethyl (S)-1-(3-((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)phenyl)piperidine-3-carboxylate

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; ruphos In toluene at 80℃;	82%

: 922161-82-8
4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)-methyl]-6-(3-hydroxy-3-methylbutoxy)phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 922161-83-9
ethyl (3S)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxy-3-methylbutoxy)phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h;	81%

: 357927-50-5
2-bromo-4-fluoro-pyridine

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: (S)-ethyl 1-(2-bromopyridin-4-yl)piperidine-3-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 100℃;	81%
With potassium carbonate In dimethyl sulfoxide at 100℃;	81%

: 179694-33-8
(S)-(+)-2-(4-cyanophenyl)oxirane

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 1265323-48-5
ethyl (3S)-1-[(2S)-2-(4-cyanophenyl)-2-hydroxyethyl]piperidine-3-carboxylate

Conditions

Conditions	Yield
With dmap In isopropyl alcohol at 50℃; Inert atmosphere; stereospecific reaction;	80%
Stage #1: (S)-(+)-2-(4-cyanophenyl)oxirane; (S)-(+)-nipecotic acid ethyl ester In isopropyl alcohol at 55℃; for 4h; Inert atmosphere; Stage #2: With dmap In isopropyl alcohol at 50℃; for 12h;	72%

: 148319-31-7
4-(3-methyl-2-thienyl)-4-(2-thienyl)-3-butenyl 4-methylbenzenesulfonate

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 148319-28-2
ethyl (S)-1-<4-(3-methyl-2-thienyl)-4-(2-thienyl)-3-butenyl>-3-piperidinecarboxylate

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In acetone for 44h; Ambient temperature;	79%

: 922160-87-0
4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-methoxyphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 922160-92-7
ethyl (3S)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-methoxyphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h;	74%

: 922161-43-1
4-[(4-chloro-2-ethoxy-6-[(S)-hydroxy(2-methoxyphenyl)-methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

A: 922161-44-2
ethyl (3S)-1-(4-[(4-chloro-2-ethoxy-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate

B: 922161-44-2
ethyl (3S)-1-(4-[(4-chloro-2-ethoxy-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2.5h;	A 7% B 74%

...Expand

Ethyl (3S)-piperidine-3-carboxylate Chemical Properties

Molecular Structure of Ethyl (3S)-piperidine-3-carboxylate (CAS NO.37675-18-6):

IUPAC Name: Ethyl (3S)-piperidine-3-carboxylate
Canonical SMILES: CCOC(=O)C1CCCNC1
Isomeric SMILES: CCOC(=O)[C@H]1CCCNC1
InChI: InChI=1S/C8H15NO2/c1-2-11-8(10)7-4-3-5-9-6-7/h7,9H,2-6H2,1H3/t7-/m0/s1
InChIKey: XIWBSOUNZWSFKU-ZETCQYMHSA-N
Molecular Weight: 157.2102 [g/mol]
Molecular Formula: C₈H₁₅NO₂
XLogP3: 0.1
H-Bond Donor: 1
H-Bond Acceptor: 3
Index of Refraction: 1.448
Molar Refractivity: 41.99 cm³
Molar Volume: 156.6 cm³
Surface Tension: 32 dyne/cm
Density: 1.003 g/cm³
Flash Point: 90.6 °C
Enthalpy of Vaporization: 47.55 kJ/mol
Boiling Point: 238.6 °C at 760 mmHg
Vapour Pressure: 0.042 mmHg at 25 °C
storage temp.: Refrigerator
Product Categories: Nitrogen cyclic compounds; Piperidine; Heterocyclic Compounds; Chiral Building Blocks; Esters (Chiral); Synthetic Organic Chemistry

Ethyl (3S)-piperidine-3-carboxylate Safety Profile

Safety Information of Ethyl (3S)-piperidine-3-carboxylate (CAS NO.37675-18-6):
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38-41
R36/37/38:Irritating to eyes, respiratory system and skin.
R41:Risk of serious damage to the eyes.
Safety Statements: 26-36/37/39-39-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S39:Wear eye / face protection.
S36:Wear suitable protective clothing.

Ethyl (3S)-piperidine-3-carboxylate Specification

Ethyl (3S)-piperidine-3-carboxylate (CAS NO.37675-18-6), its Synonyms are 3-Piperidinecarboxylicacid, ethyl ester, (S)- ; (+)-Ethyl nipecotate ; (S)-(+)-Ethyl nipecotate ; (S)-Ethyl nipecotate ; Ethyl(S)-3-piperidinecarboxylate .

Product Name

Ethyl (3S)-piperidine-3-carboxylate

Synthetic route

Ethyl (3S)-piperidine-3-carboxylate Chemical Properties

Ethyl (3S)-piperidine-3-carboxylate Safety Profile

Ethyl (3S)-piperidine-3-carboxylate Specification

Related Products

Hot Products