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Hangzhou Think Chemical Co. Ltd

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp

Alpha-Cyclopentylmandelic Acid / CPMA, CAS:427-49-6, manufacturer ,fresh stock

Cas:427-49-6

Min.Order:1 Kilogram

FOB Price: $200.0 / 250.0

Type:Other

inquiry

Anhui Dexinjia Biopharm Co., Ltd

As a leading and professional manufacturer of APIs and API intermediates in China,Anhui Dexinjia Biopharm Co., Ltd founded in 2006, Except for the R&D center, our company has built a close cooperation relation with Chinese Academy of Sciences,

Alpha-Cyclopentylmandelic Acid,Manufacturer/High quality/Best price/In stock

Cas:427-49-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

alpha-Cyclopentylmandelic acid

Cas:427-49-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Alpha-Cyclopentylmandelic Acid supplier in China

Cas:427-49-6

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Cyclopentylphenylglycolic acid

Cas:427-49-6

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality Oled CAS 427-49-6 Benzeneacetic acid, a-cyclopentyl-a-hydroxy-

Cas:427-49-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

alpha-Cyclopentylmandelic acid

Cas:427-49-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

alpha-Cyclopentylmandelic acid

Cas:427-49-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

427-49-6 alpha-Cyclopentylmandelic acid

Cas:427-49-6

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 427-49-6 with best quality

Cas:427-49-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powder 2. Fact

alpha-Cyclopentylmandelic acid CAS427-49-6

Cas:427-49-6

Min.Order:1 Kilogram

FOB Price: $20.0 / 30.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzeneacetic acid, a-cyclopentyl-a-hydroxy- 427-49-6

Cas:427-49-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

alpha-Cyclopentylmandelic acid

Cas:427-49-6

Min.Order:1 Kilogram

FOB Price: $76.0 / 85.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

alpha-Cyclopentylmandelic acid CAS:427-49-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality orga

alpha-Cyclopentylmandelic acid CAS:427-49-6

Cas:427-49-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzeneacetic acid, a-cyclopentyl-a-hydroxy-

Cas:427-49-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

alpha-Cyclopentylmandelic acid

Cas:427-49-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Lonwin Chemical Group Limited

alpha-Cyclopentylmandelic acid CAS: 427-49-6 Specification Item Standard Identification A.H-NMR:Comply with the structure B.LC-MS:Comply with the structure C.The

Factory supply alpha-Cyclopentylmandelic acid

Cas:427-49-6

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

alpha-Cyclopentylmandelic acid

Cas:427-49-6

Min.Order:1 Kilogram

FOB Price: $5.0 / 20.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzeneacetic acid, a-cyclopentyl-a-hydroxy-

Cas:427-49-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Alpha-Cyclopentylmandelic Acid

Cas:427-49-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

alpha-Cyclopentylmandelic acid 427-49-6

Cas:427-49-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

alpha-Cyclopentylmandelic acid

Cas:427-49-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

2-CYCLOPENTYL-2-HYDROXY-2-PHENYLACETIC ACID

Cas:427-49-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Hope Chem Co., Ltd

1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product

alpha-Cyclopentylmandelic Acid

Cas:427-49-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzeneacetic acid, a-cyclopentyl-a-hydroxy-

Cas:427-49-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

alpha-Cyclopentylmandelic acid

Cas:427-49-6

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Alpha-Cyclopentylmandelic Acid

Cas:427-49-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

alpha-Cyclopentylmandelic acid

Cas:427-49-6

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used in organic synthesis Transport

alpha-Cyclopentylmandelic acid

Cas:427-49-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

alpha-Cyclopentylmandelic acid Basic information Product Name: alpha-Cyclopentylmandelic acid Synonyms: ALPHA-CYCLOPENTYLMANDELIC ACID;CM ACID;CYCLOPENTYL-HYDROXY-PHENYL-ACETIC ACID;CYCLOPENTYL MANDELIC ACID;CYCLOPENTYLPHENYLGLYCOLIC ACID;TIMTEC-

427-49-6 alpha-Cyclopentylmandelic acid

Cas:427-49-6

Min.Order:1 Kilogram

FOB Price: $480.0

Type:Lab/Research institutions

inquiry

Synthetic route

glycopyrronium bromide
596-51-0

glycopyrronium bromide

A

3-hydroxy-1,1-dimethyl pyrrolidinium bromide

3-hydroxy-1,1-dimethyl pyrrolidinium bromide

B

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃;A 3.87 g
B 92%
Benzoylformic acid
611-73-4

Benzoylformic acid

cyclopentylmagnesium bromide
33240-34-5

cyclopentylmagnesium bromide

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

Conditions
ConditionsYield
In diethyl ether at 0 - 20℃; for 24.5h;36.4%
Stage #1: Benzoylformic acid; cyclopentylmagnesium bromide In diethyl ether at 0 - 20℃; for 24.5h;
Stage #2: With hydrogenchloride In diethyl ether; water
36.4%
2-Cyclopentyl-2-hydroxy-2-phenylacetic acid methyl ester
19833-96-6

2-Cyclopentyl-2-hydroxy-2-phenylacetic acid methyl ester

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

Conditions
ConditionsYield
With sodium hydroxide In methanol; water at 20℃; Inert atmosphere;25%
2-cyclopentyl-2-hydroxy-2-phenylacetic acid ethyl ester
16098-80-9

2-cyclopentyl-2-hydroxy-2-phenylacetic acid ethyl ester

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

Conditions
ConditionsYield
With potassium hydroxide In methanol at 20℃;
phenylglyoxylic acid ethyl ester
1603-79-8

phenylglyoxylic acid ethyl ester

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrahydrofuran / 0 - 20 °C
2: KOH / methanol / 20 °C
View Scheme
cyclopentylmagnesium bromide
33240-34-5

cyclopentylmagnesium bromide

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrahydrofuran / 0 - 20 °C
2: KOH / methanol / 20 °C
View Scheme
methyl 2-oxo-2-phenylacetate
15206-55-0

methyl 2-oxo-2-phenylacetate

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: iodine; magnesium / tetrahydrofuran / 0 °C / Reflux; Inert atmosphere
1.2: 10 - 20 °C / Inert atmosphere
2.1: sodium hydroxide / water; methanol / 20 °C / Inert atmosphere
View Scheme
Cyclozil chloromethacryloyloxymethylate
74240-38-3

Cyclozil chloromethacryloyloxymethylate

A

formaldehyd
50-00-0

formaldehyd

B

2-(N,N-dimethylamino)ethanol
108-01-0

2-(N,N-dimethylamino)ethanol

C

poly(methacrylic acid)
79-41-4

poly(methacrylic acid)

D

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

Conditions
ConditionsYield
With potassium chloride In methanol at 24.9℃; Rate constant; Kinetics; Mechanism; different pH values from 298-323 K, different ion strength of KCl solution;
2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

(2R)-2-cyclopentyl-2-hydroxy-2-phenylacetic acid
64471-45-0

(2R)-2-cyclopentyl-2-hydroxy-2-phenylacetic acid

Conditions
ConditionsYield
Stage #1: 2-cyclopentyl-2-hydroxy-2-phenylacetic acid With D-tyrosine methyl ester In water; acetonitrile at 0℃; for 4h; Reflux;
Stage #2: With hydrogenchloride In water; toluene at 40℃;
83.4%
With L-Tyr-OMe In acetonitrile Reflux;71%
Stage #1: 2-cyclopentyl-2-hydroxy-2-phenylacetic acid With 12-epi-strychnine In methanol at 20℃;
Stage #2: With (+)-1-phenylethylamine In ethyl acetate
33.3%
N-{[1-(Benzyl)-3-pyrrolidinyl]methyl}-N-methylamine
91189-05-8

N-{[1-(Benzyl)-3-pyrrolidinyl]methyl}-N-methylamine

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

N-(l-benzyl-pvrrolidin-3-vlmethvf)-2-cvclopentvl-2-hvdroxv-N-methyl-2-phenyl-acetamide

N-(l-benzyl-pvrrolidin-3-vlmethvf)-2-cvclopentvl-2-hvdroxv-N-methyl-2-phenyl-acetamide

Conditions
ConditionsYield
Stage #1: 2-cyclopentyl-2-hydroxy-2-phenylacetic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap In N,N-dimethyl-formamide at 15 - 20℃; for 2h;
Stage #2: N-{[1-(Benzyl)-3-pyrrolidinyl]methyl}-N-methylamine With 4-methyl-morpholine In N,N-dimethyl-formamide at 15 - 20℃; for 1 - 14h;
Stage #3: With water for 0.25h;
75.34%
2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

(3S)-1-benzyl-3-pyrrolidinamine
114715-38-7

(3S)-1-benzyl-3-pyrrolidinamine

2-cyclopentyl-2-hydroxy-N-[(3S)-1-benzyl-pyrrolidin-3-yl]-2-phenylacetamide
719278-59-8

2-cyclopentyl-2-hydroxy-N-[(3S)-1-benzyl-pyrrolidin-3-yl]-2-phenylacetamide

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol In DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 20h;95%
(R)-N-benzyl-3-hydroxypyrrolidine
101385-90-4, 101930-07-8, 101979-03-7, 775-15-5

(R)-N-benzyl-3-hydroxypyrrolidine

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

(3S)-1-benzylpyrrolidin-3-yl-cyclopentyl(hydroxy)phenyl acetate
719278-61-2

(3S)-1-benzylpyrrolidin-3-yl-cyclopentyl(hydroxy)phenyl acetate

Conditions
ConditionsYield
With triphenylphosphine In tetrahydrofuran at 20℃; for 20h;91%
2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

[1α,5α,6α]-6-Aminomethyl-3-benzyl-3-azabicyclo[3.1.0]hexane
134575-10-3

[1α,5α,6α]-6-Aminomethyl-3-benzyl-3-azabicyclo[3.1.0]hexane

(1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide
646035-40-7

(1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 0 - 20℃;95%
(1α,5α,6α)-6-aminomethyl-3-benzyl-3-azabicyclo[3.1.0]hexane
720680-79-5

(1α,5α,6α)-6-aminomethyl-3-benzyl-3-azabicyclo[3.1.0]hexane

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

(1α,5α,6α)-N-(3-benzyl-3-azabicyclo[3.1.0]hex-6-ylmethyl)-2-cyclopentyl-2-hydroxy-2-phenyl-acetamide

(1α,5α,6α)-N-(3-benzyl-3-azabicyclo[3.1.0]hex-6-ylmethyl)-2-cyclopentyl-2-hydroxy-2-phenyl-acetamide

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 0 - 20℃;95%
2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

methyl iodide
74-88-4

methyl iodide

2-Cyclopentyl-2-hydroxy-2-phenylacetic acid methyl ester
19833-96-6

2-Cyclopentyl-2-hydroxy-2-phenylacetic acid methyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;64%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;35%
l-((R)-α-methyl benzyl)-3-pyrrolidin methanol

l-((R)-α-methyl benzyl)-3-pyrrolidin methanol

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

(2R,2S)-[(3'R, 3'S)-1'-((R)-α-methvl-benzvl)-pvrrolidin-3'-vlmethvl]-2-hvdroxv-2-cvcopentvl-2-phenvlacetic acid ester

(2R,2S)-[(3'R, 3'S)-1'-((R)-α-methvl-benzvl)-pvrrolidin-3'-vlmethvl]-2-hvdroxv-2-cvcopentvl-2-phenvlacetic acid ester

Conditions
ConditionsYield
Stage #1: l-((R)-α-methyl benzyl)-3-pyrrolidin methanol; 2-cyclopentyl-2-hydroxy-2-phenylacetic acid With 4-methyl-morpholine; benzotriazol-1-ol In N,N-dimethyl-formamide at 0 - 5℃; for 1h;
Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 30℃; for 16h;
17%
4-amino-1-benzylpiperidine
50541-93-0

4-amino-1-benzylpiperidine

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

N-(1-benzyl-piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenyl-acetamide
186755-46-4

N-(1-benzyl-piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenyl-acetamide

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In chloroform at 20℃; for 14h;94%
4-(1,5-dimethyl-3-azabicyclo[3.1.0]hex-3-yl)-2-butynol

4-(1,5-dimethyl-3-azabicyclo[3.1.0]hex-3-yl)-2-butynol

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

4-[(1R,5S)-1,5-dimethyl-3-aza-bicyclo[3.1.0]hex-3-yl]but-2-ynyl-2-cyclopentyl-2-hydroxy phenylacetate

4-[(1R,5S)-1,5-dimethyl-3-aza-bicyclo[3.1.0]hex-3-yl]but-2-ynyl-2-cyclopentyl-2-hydroxy phenylacetate

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 60h;
[1α,5α,6α]-6-(N-Methyl)tert-butoxycarbonylamino-3-azabicyclo[3.1.0]hexane
134575-41-0

[1α,5α,6α]-6-(N-Methyl)tert-butoxycarbonylamino-3-azabicyclo[3.1.0]hexane

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

tert-butyl {3-[cyclopentyl(hydroxy)phenylacetyl]-3-azabicyclo [3.1.0]hex-6-yl}methylcarbamate

tert-butyl {3-[cyclopentyl(hydroxy)phenylacetyl]-3-azabicyclo [3.1.0]hex-6-yl}methylcarbamate

Conditions
ConditionsYield
Stage #1: [1α,5α,6α]-6-(N-Methyl)tert-butoxycarbonylamino-3-azabicyclo[3.1.0]hexane; 2-cyclopentyl-2-hydroxy-2-phenylacetic acid With 4-methyl-morpholine; benzotriazol-1-ol In N,N-dimethyl-formamide at 0℃; for 1h;
Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃;
2-(1H-imidazol-1-yl)ethanamine hydrochloride
154094-97-0

2-(1H-imidazol-1-yl)ethanamine hydrochloride

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

2-cyclopentyl-2-hydroxy-N-[2-(1H-imidazol-1-yl)ethyl]-2-phenylacetamide

2-cyclopentyl-2-hydroxy-N-[2-(1H-imidazol-1-yl)ethyl]-2-phenylacetamide

Conditions
ConditionsYield
Stage #1: 2-(1H-imidazol-1-yl)ethanamine hydrochloride With 4-methyl-morpholine In chloroform at 20℃; for 0.0833333 - 0.166667h;
Stage #2: 2-cyclopentyl-2-hydroxy-2-phenylacetic acid With benzotriazol-1-ol In chloroform at 20℃; for 0.5 - 0.75h;
Stage #3: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In chloroform
2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

1-cyclopentylidene-1-phenylacetic acid
126497-27-6

1-cyclopentylidene-1-phenylacetic acid

Conditions
ConditionsYield
With hydrogenchloride In water for 48h; Reflux;81%
With hydrogenchloride In water for 49h; Reflux; Inert atmosphere;63%
With hydrogenchloride In water for 48h; Reflux;
2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

C22H32N2O4

C22H32N2O4

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;
N,N',N'-trimethylenediamine
142-25-6

N,N',N'-trimethylenediamine

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

C18H28N2O2

C18H28N2O2

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;
benzyl chloride
100-44-7

benzyl chloride

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

C20H22O3

C20H22O3

Conditions
ConditionsYield
Stage #1: 2-cyclopentyl-2-hydroxy-2-phenylacetic acid With sodium hydroxide In N,N-dimethyl-formamide at 60℃; for 1h;
Stage #2: benzyl chloride In N,N-dimethyl-formamide at 110℃; for 3h;
285 g
2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

1-methylpyrrolidin-3-yl methanesulfonate
91832-73-4

1-methylpyrrolidin-3-yl methanesulfonate

3-(2-cyclopentyl-2-hydroxy-2-phenylacetyloxy)-1-methylpyrrolidine
13118-11-1

3-(2-cyclopentyl-2-hydroxy-2-phenylacetyloxy)-1-methylpyrrolidine

Conditions
ConditionsYield
With sodium carbonate In acetonitrile at 75 - 80℃;30 g
toluene-4-sulfonic acid 1-methylpyrrolidin-3-yl ester
60499-30-1

toluene-4-sulfonic acid 1-methylpyrrolidin-3-yl ester

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

3-(2-cyclopentyl-2-hydroxy-2-phenylacetyloxy)-1-methylpyrrolidine
13118-11-1

3-(2-cyclopentyl-2-hydroxy-2-phenylacetyloxy)-1-methylpyrrolidine

Conditions
ConditionsYield
With sodium carbonate In acetonitrile at 75 - 80℃;11.5 g
metoclopramide
364-62-5

metoclopramide

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

2-chloro-4-{[2-(diethylamino)ethyl]carbamoyl}-5-methoxyanilinium-2-cyclopentyl-2-hydroxy-2-phenylacetate

2-chloro-4-{[2-(diethylamino)ethyl]carbamoyl}-5-methoxyanilinium-2-cyclopentyl-2-hydroxy-2-phenylacetate

Conditions
ConditionsYield
In acetone for 6h; Inert atmosphere; Reflux;80%
2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

N-(piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenylacetamide
185030-18-6

N-(piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenylacetamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 94 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / CHCl3 / 14 h / 20 °C
2: 74 percent / H2 / 20percent Pd(OH)2 / ethanol / 8 h / 760.05 Torr
View Scheme
With sodium hydroxide In ethyl acetate
2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

2-cyclopentyl-2-hydroxy-1-(1H-imidazol-1-yl)-2-phenylethanone
1246930-41-5

2-cyclopentyl-2-hydroxy-1-(1H-imidazol-1-yl)-2-phenylethanone

Conditions
ConditionsYield
In acetonitrile at 0 - 20℃; for 2h;
In acetonitrile at 0 - 20℃; for 2h; Inert atmosphere;7.3 g
1-methyl-3-pyrrolidinol
13220-33-2

1-methyl-3-pyrrolidinol

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

3-(2-cyclopentyl-2-hydroxy-2-phenylacetyloxy)-1-methylpyrrolidine
13118-11-1

3-(2-cyclopentyl-2-hydroxy-2-phenylacetyloxy)-1-methylpyrrolidine

Conditions
ConditionsYield
Stage #1: 2-cyclopentyl-2-hydroxy-2-phenylacetic acid With 1,1'-carbonyldiimidazole In toluene at 20℃; for 0.5h;
Stage #2: 1-methyl-3-pyrrolidinol In toluene at 20℃;
71%
Stage #1: 2-cyclopentyl-2-hydroxy-2-phenylacetic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 18℃;
Stage #2: 1-methyl-3-pyrrolidinol In N,N-dimethyl-formamide at 18 - 60℃; for 19h; Product distribution / selectivity;
With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 18 - 60℃; for 19h; Inert atmosphere;
Stage #1: 2-cyclopentyl-2-hydroxy-2-phenylacetic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 20℃; for 0.333333h;
Stage #2: 1-methyl-3-pyrrolidinol In N,N-dimethyl-formamide at 60℃;
Ca.580 g
2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

phenyl cyclopentyl ketone
5422-88-8

phenyl cyclopentyl ketone

Conditions
ConditionsYield
With oxygen; copper diacetate In dimethyl sulfoxide at 120℃; for 10h; Sealed tube;93%
2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

cyclopentylphenylmethanol
110480-94-9, 4397-01-7

cyclopentylphenylmethanol

Conditions
ConditionsYield
With sodium tetrahydroborate; [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; oxygen; caesium carbonate In dichloromethane at 40℃; for 40h; Irradiation;92%
3-benzyl-1-methanesulphonyl-3-azabicyclo[3.1.0]hexane

3-benzyl-1-methanesulphonyl-3-azabicyclo[3.1.0]hexane

2-cyclopentyl-2-hydroxy-2-phenylacetic acid
427-49-6

2-cyclopentyl-2-hydroxy-2-phenylacetic acid

(1α,5α)-[3-benzyl-3-azabicyclo[3.1.0]hex-1-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenylcarboxylic ester

(1α,5α)-[3-benzyl-3-azabicyclo[3.1.0]hex-1-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenylcarboxylic ester

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene for 2h; Heating / reflux;

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