CAS No.478149-53-0,N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride Suppliers,MSDS download

Shandong Hanjiang Chemical Co., Ltd.

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N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

478149-53-0 CAS NO.478149-53-0

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Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride

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Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

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Henan Tianfu Chemical Co., Ltd.

1.Our services：A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride

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Changchun Artel lmport and Export trade company

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Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride

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ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride

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Jilin haofei import and export trade Co.,Ltd

Price, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right

478149-53-0 CAS NO.478149-53-0

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Shanghai united Scientific Co.,Ltd.

United Scientific Company Located in Shanghai of China , is a competitive player in the global specialty and fine chemical market. Fenghua has both the expertise and flexibility to produce a wide range of chemicals. Focusing on developing the innovat

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride

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Chungking Joyinchem Co., Ltd.

Joyinchem have been committed to chemical supply for several years and have built good cooperation records with multinational chemical corporations and importers from all over the world. Our services include:-Spot goods-Contract manufacturing-Custom

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride

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Shanghai AngewChem Co., Ltd.

Shanghai AngewChemCo., Ltd. is an innovative enterprise on fine chemicals and pharmaceuticals. Based on Shanghai R&D center and Hunan chemical manufacturing plant, we offer chemical research, process development, and large-scale production. Complete

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Nanjing Raymon Biotech Co., Ltd.

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochlorideAppearance:Off white to slight yellow solid Storage:Store in dry and cool condition Package:25kg or according to cutomer's demand Application:Chemical research/Pharmace

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride

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Wuxi Morality Chemical Co., Ltd

Do best quality products, erect the morality model Application:please email us, thanks

PHA 543613 hydrochloride;N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxaMidehydrochloride

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Synthetic route

: 478148-62-8
furo[2,3-c]pyridine-5-carboxylic acid

: 137661-31-5
(R)-quinuclidine-3-amine hydrochloride

: 478149-53-0
PHA-543613

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In chloroform at 20℃; for 16h;	66%

: 478148-62-8
furo[2,3-c]pyridine-5-carboxylic acid

: 6530-09-2, 119904-90-4, 120538-52-5, 123536-14-1, 124577-62-4, 126358-22-3, 137661-30-4, 137661-31-5
(3R)-quinuclidin-3-amine dihydrochloride

: 478149-53-0
PHA-543613

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 3h;
With N-ethyl-N,N-diisopropylamine; HATU In DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 2.5h;

: 478148-61-7
furo[2,3-c]pyridine-5-carbaldehyde

: 478149-53-0
PHA-543613

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aq. KH2PO4; sodium chlorite / dimethylsulfoxide 2: diisopropylethylamine; O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF6 / dimethylformamide / 3 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C 2: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C View Scheme

: 478148-60-6
furo[2,3-c]pyridin-5-yl methanol

: 478149-53-0
PHA-543613

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 86 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 20 °C 2: aq. KH2PO4; sodium chlorite / dimethylsulfoxide 3: diisopropylethylamine; O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF6 / dimethylformamide / 3 h / 20 °C View Scheme
Multi-step reaction with 3 steps 1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C 1.2: 1 h / -78 - 20 °C 2.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C 3.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C View Scheme

: 6636-78-8
2-chloro-3-hydroxypyridine

: 478149-53-0
PHA-543613

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1: aq. NaHCO3 / 15 h / 90 °C 2: aq. NaHCO3; I2 / 48 h / 20 °C 3: 11.4 g / Pd(PPh3)2Cl2; CuI; Et3N / tetrahydrofuran; CHCl3 / 3 h / 20 °C 4: CuI; diisopropylamine / methanol / 6 h / 45 - 50 °C 5: 19.5 g / Zn; aq. HCl / ethanol / 1 h / Heating 6: 86 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 20 °C 7: aq. KH2PO4; sodium chlorite / dimethylsulfoxide 8: diisopropylethylamine; O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF6 / dimethylformamide / 3 h / 20 °C View Scheme
Multi-step reaction with 8 steps 1.1: sodium hydrogencarbonate / water / 26.5 h / 90 °C 2.1: iodine; sodium hydrogencarbonate / water / 20 °C 3.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; chloroform / 3 h / 20 °C 4.1: triethylamine / copper(l) iodide / ethanol / 3.5 h / 70 °C 5.1: hydrogenchloride; zinc / ethanol; water / 1 h / 70 °C / Heating / reflux 6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C 6.2: 1 h / -78 - 20 °C 7.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C 8.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C View Scheme
Multi-step reaction with 8 steps 1.1: sodium hydrogencarbonate / water / 26.5 h / 90 °C 2.1: iodine; sodium hydrogencarbonate / water / 20 °C 3.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; chloroform / 3 h / 20 °C 4.1: diisopropylamine / copper(l) iodide / methanol / 6 h / 45 - 50 °C 5.1: hydrogenchloride; zinc / ethanol; water / 1 h / 70 °C / Heating / reflux 6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C 6.2: 1 h / -78 - 20 °C 7.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C 8.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C View Scheme
Multi-step reaction with 9 steps 1.1: sodium hydrogencarbonate / water / 26.5 h / 90 °C 2.1: iodine; sodium hydrogencarbonate / water / 20 °C 3.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; chloroform / 3 h / 20 °C 4.1: triethylamine / copper(l) iodide / ethanol / 3.5 h / 70 °C 5.1: palladium 10% on activated carbon; cyclohexene / ethanol / 2.5 h / Heating / reflux 6.1: sodium hydroxide / methanol; water / 1.5 h / 20 °C 7.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C 7.2: 1 h / -78 - 20 °C 8.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C 9.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C View Scheme

: 208519-41-9
2-chloro-6-(hydroxymethyl)-3-pyridinol

: 478149-53-0
PHA-543613

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: aq. NaHCO3; I2 / 48 h / 20 °C 2: 11.4 g / Pd(PPh3)2Cl2; CuI; Et3N / tetrahydrofuran; CHCl3 / 3 h / 20 °C 3: CuI; diisopropylamine / methanol / 6 h / 45 - 50 °C 4: 19.5 g / Zn; aq. HCl / ethanol / 1 h / Heating 5: 86 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 20 °C 6: aq. KH2PO4; sodium chlorite / dimethylsulfoxide 7: diisopropylethylamine; O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF6 / dimethylformamide / 3 h / 20 °C View Scheme
Multi-step reaction with 7 steps 1.1: iodine; sodium hydrogencarbonate / water / 20 °C 2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; chloroform / 3 h / 20 °C 3.1: triethylamine / copper(l) iodide / ethanol / 3.5 h / 70 °C 4.1: hydrogenchloride; zinc / ethanol; water / 1 h / 70 °C / Heating / reflux 5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C 5.2: 1 h / -78 - 20 °C 6.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C 7.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C View Scheme
Multi-step reaction with 7 steps 1.1: iodine; sodium hydrogencarbonate / water / 20 °C 2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; chloroform / 3 h / 20 °C 3.1: diisopropylamine / copper(l) iodide / methanol / 6 h / 45 - 50 °C 4.1: hydrogenchloride; zinc / ethanol; water / 1 h / 70 °C / Heating / reflux 5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C 5.2: 1 h / -78 - 20 °C 6.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C 7.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C View Scheme
Multi-step reaction with 8 steps 1.1: iodine; sodium hydrogencarbonate / water / 20 °C 2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; chloroform / 3 h / 20 °C 3.1: triethylamine / copper(l) iodide / ethanol / 3.5 h / 70 °C 4.1: palladium 10% on activated carbon; cyclohexene / ethanol / 2.5 h / Heating / reflux 5.1: sodium hydroxide / methanol; water / 1.5 h / 20 °C 6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C 6.2: 1 h / -78 - 20 °C 7.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C 8.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C View Scheme

: 208519-39-5
(7-chlorofuro[2,3-c]pyridin-5-yl)methanol

: 478149-53-0
PHA-543613

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 19.5 g / Zn; aq. HCl / ethanol / 1 h / Heating 2: 86 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 20 °C 3: aq. KH2PO4; sodium chlorite / dimethylsulfoxide 4: diisopropylethylamine; O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF6 / dimethylformamide / 3 h / 20 °C View Scheme
Multi-step reaction with 4 steps 1.1: hydrogenchloride; zinc / ethanol; water / 1 h / 70 °C / Heating / reflux 2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C 2.2: 1 h / -78 - 20 °C 3.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C 4.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C View Scheme

Yield

Multi-step reaction with 4 steps
1: 19.5 g / Zn; aq. HCl / ethanol / 1 h / Heating
2: 86 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
3: aq. KH2PO4; sodium chlorite / dimethylsulfoxide
4: diisopropylethylamine; O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF6 / dimethylformamide / 3 h / 20 °C
View Scheme

Multi-step reaction with 4 steps
1.1: hydrogenchloride; zinc / ethanol; water / 1 h / 70 °C / Heating / reflux
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C
2.2: 1 h / -78 - 20 °C
3.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C
4.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C
View Scheme

: 208519-37-3
2-chloro-3-hydroxy-6-(hydroxymethyl)-4-iodopyridine

: 478149-53-0
PHA-543613

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 11.4 g / Pd(PPh3)2Cl2; CuI; Et3N / tetrahydrofuran; CHCl3 / 3 h / 20 °C 2: CuI; diisopropylamine / methanol / 6 h / 45 - 50 °C 3: 19.5 g / Zn; aq. HCl / ethanol / 1 h / Heating 4: 86 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 20 °C 5: aq. KH2PO4; sodium chlorite / dimethylsulfoxide 6: diisopropylethylamine; O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF6 / dimethylformamide / 3 h / 20 °C View Scheme
Multi-step reaction with 6 steps 1.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; chloroform / 3 h / 20 °C 2.1: triethylamine / copper(l) iodide / ethanol / 3.5 h / 70 °C 3.1: hydrogenchloride; zinc / ethanol; water / 1 h / 70 °C / Heating / reflux 4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C 4.2: 1 h / -78 - 20 °C 5.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C 6.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C View Scheme
Multi-step reaction with 6 steps 1.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; chloroform / 3 h / 20 °C 2.1: diisopropylamine / copper(l) iodide / methanol / 6 h / 45 - 50 °C 3.1: hydrogenchloride; zinc / ethanol; water / 1 h / 70 °C / Heating / reflux 4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C 4.2: 1 h / -78 - 20 °C 5.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C 6.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C View Scheme
Multi-step reaction with 7 steps 1.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; chloroform / 3 h / 20 °C 2.1: triethylamine / copper(l) iodide / ethanol / 3.5 h / 70 °C 3.1: palladium 10% on activated carbon; cyclohexene / ethanol / 2.5 h / Heating / reflux 4.1: sodium hydroxide / methanol; water / 1.5 h / 20 °C 5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C 5.2: 1 h / -78 - 20 °C 6.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C 7.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C View Scheme

: 208519-38-4
2-chloro-6-(hydroxymethyl)-4-[(trimethylsilyl)ethynyl]-3-pyridinol

: 478149-53-0
PHA-543613

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: CuI; diisopropylamine / methanol / 6 h / 45 - 50 °C 2: 19.5 g / Zn; aq. HCl / ethanol / 1 h / Heating 3: 86 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 20 °C 4: aq. KH2PO4; sodium chlorite / dimethylsulfoxide 5: diisopropylethylamine; O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF6 / dimethylformamide / 3 h / 20 °C View Scheme
Multi-step reaction with 5 steps 1.1: triethylamine / copper(l) iodide / ethanol / 3.5 h / 70 °C 2.1: hydrogenchloride; zinc / ethanol; water / 1 h / 70 °C / Heating / reflux 3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C 3.2: 1 h / -78 - 20 °C 4.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C 5.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C View Scheme
Multi-step reaction with 5 steps 1.1: diisopropylamine / copper(l) iodide / methanol / 6 h / 45 - 50 °C 2.1: hydrogenchloride; zinc / ethanol; water / 1 h / 70 °C / Heating / reflux 3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C 3.2: 1 h / -78 - 20 °C 4.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C 5.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C View Scheme
Multi-step reaction with 6 steps 1.1: triethylamine / copper(l) iodide / ethanol / 3.5 h / 70 °C 2.1: palladium 10% on activated carbon; cyclohexene / ethanol / 2.5 h / Heating / reflux 3.1: sodium hydroxide / methanol; water / 1.5 h / 20 °C 4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C 4.2: 1 h / -78 - 20 °C 5.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C 6.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C View Scheme

: 478148-59-3
5-hydroxymethyl-2-trimethylsilyl-furo[2,3-c]pyridine

: 478149-53-0
PHA-543613

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: sodium hydroxide / methanol; water / 1.5 h / 20 °C 2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C 2.2: 1 h / -78 - 20 °C 3.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C 4.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C View Scheme

: 441044-90-2
[7-chloro-2-(trimethylsilyl)furo[2,3-c]pyridin-5-yl]methanol

: 478149-53-0
PHA-543613

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: palladium 10% on activated carbon; cyclohexene / ethanol / 2.5 h / Heating / reflux 2.1: sodium hydroxide / methanol; water / 1.5 h / 20 °C 3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C 3.2: 1 h / -78 - 20 °C 4.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C 5.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C View Scheme

Yield

Multi-step reaction with 5 steps
1.1: palladium 10% on activated carbon; cyclohexene / ethanol / 2.5 h / Heating / reflux
2.1: sodium hydroxide / methanol; water / 1.5 h / 20 °C
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C
3.2: 1 h / -78 - 20 °C
4.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C
5.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C
View Scheme

: 478149-53-0
PHA-543613

: 110-17-8
(2E)-but-2-enedioic acid

: 708261-37-4
N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, mono-fumarate salt

Conditions

Conditions	Yield
In water; butan-1-ol at 70 - 80℃;	87%
In methanol; isopropyl alcohol; acetone	86%

: 478149-53-0
PHA-543613

: 110-17-8
(2E)-but-2-enedioic acid

: N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, hemi-fumarate salt

Conditions

Conditions	Yield
In isopropyl alcohol at 20 - 75℃; for 7 - 22h;	87%

: 478149-53-0
PHA-543613

: PHA-543,613

Conditions

Conditions	Yield
With hydrogenchloride In ethyl acetate at 20℃; for 0.166667h;	84%

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