Welcome to LookChem.com Sign In|Join Free

CAS

  • or

478149-53-0

478149-53-0

Post Buying Request

478149-53-0 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

478149-53-0 Usage

General Description

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride, also known as PHA 543613 hydrochloride, is a chemical compound with potential pharmaceutical applications. It belongs to the class of furo[2,3-c]pyridine derivatives and is believed to have activity as a nicotinic acetylcholine receptor agonist. N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride may have potential use in the treatment of neurological disorders and other conditions related to acetylcholine receptor function. Its precise pharmacological properties and potential therapeutic uses are still being investigated in preclinical and clinical studies.

Check Digit Verification of cas no

The CAS Registry Mumber 478149-53-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,8,1,4 and 9 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 478149-53:
(8*4)+(7*7)+(6*8)+(5*1)+(4*4)+(3*9)+(2*5)+(1*3)=190
190 % 10 = 0
So 478149-53-0 is a valid CAS Registry Number.

478149-53-0 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail

  • Sigma

  • (PZ0135)  PHA-543613  ≥98% (HPLC)

  • 478149-53-0

  • PZ0135-5MG

  • 1,236.69CNY

  • Detail

  • Sigma

  • (PZ0135)  PHA-543613  ≥98% (HPLC)

  • 478149-53-0

  • PZ0135-25MG

  • 4,947.93CNY

  • Detail

478149-53-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide

1.2 Other means of identification

Product number -
Other names N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-c]pyridine-5-carboxamide,hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:478149-53-0 SDS

478149-53-0Synthetic route

furo[2,3-c]pyridine-5-carboxylic acid
478148-62-8

furo[2,3-c]pyridine-5-carboxylic acid

(R)-quinuclidine-3-amine hydrochloride
137661-31-5

(R)-quinuclidine-3-amine hydrochloride

PHA-543613
478149-53-0

PHA-543613

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In chloroform at 20℃; for 16h;66%
furo[2,3-c]pyridine-5-carboxylic acid
478148-62-8

furo[2,3-c]pyridine-5-carboxylic acid

(3R)-quinuclidin-3-amine dihydrochloride
6530-09-2, 119904-90-4, 120538-52-5, 123536-14-1, 124577-62-4, 126358-22-3, 137661-30-4, 137661-31-5

(3R)-quinuclidin-3-amine dihydrochloride

PHA-543613
478149-53-0

PHA-543613

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 3h;
With N-ethyl-N,N-diisopropylamine; HATU In DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 2.5h;
furo[2,3-c]pyridine-5-carbaldehyde
478148-61-7

furo[2,3-c]pyridine-5-carbaldehyde

PHA-543613
478149-53-0

PHA-543613

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. KH2PO4; sodium chlorite / dimethylsulfoxide
2: diisopropylethylamine; O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF6 / dimethylformamide / 3 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C
2: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C
View Scheme
furo[2,3-c]pyridin-5-yl methanol
478148-60-6

furo[2,3-c]pyridin-5-yl methanol

PHA-543613
478149-53-0

PHA-543613

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 86 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
2: aq. KH2PO4; sodium chlorite / dimethylsulfoxide
3: diisopropylethylamine; O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF6 / dimethylformamide / 3 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C
1.2: 1 h / -78 - 20 °C
2.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C
3.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C
View Scheme
2-chloro-3-hydroxypyridine
6636-78-8

2-chloro-3-hydroxypyridine

PHA-543613
478149-53-0

PHA-543613

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: aq. NaHCO3 / 15 h / 90 °C
2: aq. NaHCO3; I2 / 48 h / 20 °C
3: 11.4 g / Pd(PPh3)2Cl2; CuI; Et3N / tetrahydrofuran; CHCl3 / 3 h / 20 °C
4: CuI; diisopropylamine / methanol / 6 h / 45 - 50 °C
5: 19.5 g / Zn; aq. HCl / ethanol / 1 h / Heating
6: 86 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
7: aq. KH2PO4; sodium chlorite / dimethylsulfoxide
8: diisopropylethylamine; O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF6 / dimethylformamide / 3 h / 20 °C
View Scheme
Multi-step reaction with 8 steps
1.1: sodium hydrogencarbonate / water / 26.5 h / 90 °C
2.1: iodine; sodium hydrogencarbonate / water / 20 °C
3.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; chloroform / 3 h / 20 °C
4.1: triethylamine / copper(l) iodide / ethanol / 3.5 h / 70 °C
5.1: hydrogenchloride; zinc / ethanol; water / 1 h / 70 °C / Heating / reflux
6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C
6.2: 1 h / -78 - 20 °C
7.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C
8.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C
View Scheme
Multi-step reaction with 8 steps
1.1: sodium hydrogencarbonate / water / 26.5 h / 90 °C
2.1: iodine; sodium hydrogencarbonate / water / 20 °C
3.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; chloroform / 3 h / 20 °C
4.1: diisopropylamine / copper(l) iodide / methanol / 6 h / 45 - 50 °C
5.1: hydrogenchloride; zinc / ethanol; water / 1 h / 70 °C / Heating / reflux
6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C
6.2: 1 h / -78 - 20 °C
7.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C
8.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C
View Scheme
Multi-step reaction with 9 steps
1.1: sodium hydrogencarbonate / water / 26.5 h / 90 °C
2.1: iodine; sodium hydrogencarbonate / water / 20 °C
3.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; chloroform / 3 h / 20 °C
4.1: triethylamine / copper(l) iodide / ethanol / 3.5 h / 70 °C
5.1: palladium 10% on activated carbon; cyclohexene / ethanol / 2.5 h / Heating / reflux
6.1: sodium hydroxide / methanol; water / 1.5 h / 20 °C
7.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C
7.2: 1 h / -78 - 20 °C
8.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C
9.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C
View Scheme
2-chloro-6-(hydroxymethyl)-3-pyridinol
208519-41-9

2-chloro-6-(hydroxymethyl)-3-pyridinol

PHA-543613
478149-53-0

PHA-543613

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: aq. NaHCO3; I2 / 48 h / 20 °C
2: 11.4 g / Pd(PPh3)2Cl2; CuI; Et3N / tetrahydrofuran; CHCl3 / 3 h / 20 °C
3: CuI; diisopropylamine / methanol / 6 h / 45 - 50 °C
4: 19.5 g / Zn; aq. HCl / ethanol / 1 h / Heating
5: 86 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
6: aq. KH2PO4; sodium chlorite / dimethylsulfoxide
7: diisopropylethylamine; O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF6 / dimethylformamide / 3 h / 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: iodine; sodium hydrogencarbonate / water / 20 °C
2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; chloroform / 3 h / 20 °C
3.1: triethylamine / copper(l) iodide / ethanol / 3.5 h / 70 °C
4.1: hydrogenchloride; zinc / ethanol; water / 1 h / 70 °C / Heating / reflux
5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C
5.2: 1 h / -78 - 20 °C
6.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C
7.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: iodine; sodium hydrogencarbonate / water / 20 °C
2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; chloroform / 3 h / 20 °C
3.1: diisopropylamine / copper(l) iodide / methanol / 6 h / 45 - 50 °C
4.1: hydrogenchloride; zinc / ethanol; water / 1 h / 70 °C / Heating / reflux
5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C
5.2: 1 h / -78 - 20 °C
6.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C
7.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C
View Scheme
Multi-step reaction with 8 steps
1.1: iodine; sodium hydrogencarbonate / water / 20 °C
2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; chloroform / 3 h / 20 °C
3.1: triethylamine / copper(l) iodide / ethanol / 3.5 h / 70 °C
4.1: palladium 10% on activated carbon; cyclohexene / ethanol / 2.5 h / Heating / reflux
5.1: sodium hydroxide / methanol; water / 1.5 h / 20 °C
6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C
6.2: 1 h / -78 - 20 °C
7.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C
8.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C
View Scheme
(7-chlorofuro[2,3-c]pyridin-5-yl)methanol
208519-39-5

(7-chlorofuro[2,3-c]pyridin-5-yl)methanol

PHA-543613
478149-53-0

PHA-543613

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 19.5 g / Zn; aq. HCl / ethanol / 1 h / Heating
2: 86 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
3: aq. KH2PO4; sodium chlorite / dimethylsulfoxide
4: diisopropylethylamine; O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF6 / dimethylformamide / 3 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: hydrogenchloride; zinc / ethanol; water / 1 h / 70 °C / Heating / reflux
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C
2.2: 1 h / -78 - 20 °C
3.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C
4.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C
View Scheme
2-chloro-3-hydroxy-6-(hydroxymethyl)-4-iodopyridine
208519-37-3

2-chloro-3-hydroxy-6-(hydroxymethyl)-4-iodopyridine

PHA-543613
478149-53-0

PHA-543613

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 11.4 g / Pd(PPh3)2Cl2; CuI; Et3N / tetrahydrofuran; CHCl3 / 3 h / 20 °C
2: CuI; diisopropylamine / methanol / 6 h / 45 - 50 °C
3: 19.5 g / Zn; aq. HCl / ethanol / 1 h / Heating
4: 86 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
5: aq. KH2PO4; sodium chlorite / dimethylsulfoxide
6: diisopropylethylamine; O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF6 / dimethylformamide / 3 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; chloroform / 3 h / 20 °C
2.1: triethylamine / copper(l) iodide / ethanol / 3.5 h / 70 °C
3.1: hydrogenchloride; zinc / ethanol; water / 1 h / 70 °C / Heating / reflux
4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C
4.2: 1 h / -78 - 20 °C
5.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C
6.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; chloroform / 3 h / 20 °C
2.1: diisopropylamine / copper(l) iodide / methanol / 6 h / 45 - 50 °C
3.1: hydrogenchloride; zinc / ethanol; water / 1 h / 70 °C / Heating / reflux
4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C
4.2: 1 h / -78 - 20 °C
5.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C
6.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran; chloroform / 3 h / 20 °C
2.1: triethylamine / copper(l) iodide / ethanol / 3.5 h / 70 °C
3.1: palladium 10% on activated carbon; cyclohexene / ethanol / 2.5 h / Heating / reflux
4.1: sodium hydroxide / methanol; water / 1.5 h / 20 °C
5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C
5.2: 1 h / -78 - 20 °C
6.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C
7.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C
View Scheme
2-chloro-6-(hydroxymethyl)-4-[(trimethylsilyl)ethynyl]-3-pyridinol
208519-38-4

2-chloro-6-(hydroxymethyl)-4-[(trimethylsilyl)ethynyl]-3-pyridinol

PHA-543613
478149-53-0

PHA-543613

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: CuI; diisopropylamine / methanol / 6 h / 45 - 50 °C
2: 19.5 g / Zn; aq. HCl / ethanol / 1 h / Heating
3: 86 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
4: aq. KH2PO4; sodium chlorite / dimethylsulfoxide
5: diisopropylethylamine; O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF6 / dimethylformamide / 3 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: triethylamine / copper(l) iodide / ethanol / 3.5 h / 70 °C
2.1: hydrogenchloride; zinc / ethanol; water / 1 h / 70 °C / Heating / reflux
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C
3.2: 1 h / -78 - 20 °C
4.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C
5.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: diisopropylamine / copper(l) iodide / methanol / 6 h / 45 - 50 °C
2.1: hydrogenchloride; zinc / ethanol; water / 1 h / 70 °C / Heating / reflux
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C
3.2: 1 h / -78 - 20 °C
4.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C
5.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: triethylamine / copper(l) iodide / ethanol / 3.5 h / 70 °C
2.1: palladium 10% on activated carbon; cyclohexene / ethanol / 2.5 h / Heating / reflux
3.1: sodium hydroxide / methanol; water / 1.5 h / 20 °C
4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C
4.2: 1 h / -78 - 20 °C
5.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C
6.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C
View Scheme
5-hydroxymethyl-2-trimethylsilyl-furo[2,3-c]pyridine
478148-59-3

5-hydroxymethyl-2-trimethylsilyl-furo[2,3-c]pyridine

PHA-543613
478149-53-0

PHA-543613

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydroxide / methanol; water / 1.5 h / 20 °C
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C
2.2: 1 h / -78 - 20 °C
3.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C
4.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C
View Scheme
[7-chloro-2-(trimethylsilyl)furo[2,3-c]pyridin-5-yl]methanol
441044-90-2

[7-chloro-2-(trimethylsilyl)furo[2,3-c]pyridin-5-yl]methanol

PHA-543613
478149-53-0

PHA-543613

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: palladium 10% on activated carbon; cyclohexene / ethanol / 2.5 h / Heating / reflux
2.1: sodium hydroxide / methanol; water / 1.5 h / 20 °C
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C
3.2: 1 h / -78 - 20 °C
4.1: sodium chlorite; potassium dihydrogenphosphate / water; dimethyl sulfoxide / 3 h / 20 °C
5.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 2.5 h / 0 - 20 °C
View Scheme
PHA-543613
478149-53-0

PHA-543613

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, mono-fumarate salt
708261-37-4

N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, mono-fumarate salt

Conditions
ConditionsYield
In water; butan-1-ol at 70 - 80℃;87%
In methanol; isopropyl alcohol; acetone86%
PHA-543613
478149-53-0

PHA-543613

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, hemi-fumarate salt

N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, hemi-fumarate salt

Conditions
ConditionsYield
In isopropyl alcohol at 20 - 75℃; for 7 - 22h;87%
PHA-543613
478149-53-0

PHA-543613

PHA-543,613

PHA-543,613

Conditions
ConditionsYield
With hydrogenchloride In ethyl acetate at 20℃; for 0.166667h;84%

478149-53-0Downstream Products

478149-53-0Relevant articles and documents

ANTIPRURITIC AGENT

-

Paragraph 0190; 0191; 0192; 0193; 0194; 0195, (2014/05/20)

An antipruritic which exerts an antipruritic effect based on a novel action mechanism and is effective for pruritus. The antipruritic contains as an effective ingredient a compound which activates a central type nicotinic acetylcholine receptor.

CRYSTALLINE FUMARATE SALTS OF 1-AZABICYCLO[2.2.2]OCT SUBSTITUTED FURO[2,3-C]PYRIDINYL CARBOXAMIDE AND COMPOSITIONS AND PREPARATIONS THEREOF

-

, (2008/06/13)

The invention provides fumarate salts of N-[1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, compositions, racemic mixtures, or pure enantiomers thereof, and preparation thereof. The fumarate salts are useful to treat diseases or conditions in which α7 nAChR is known to be involved. Formula (I).

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 478149-53-0