As a leading and professional manufacturer of APIs and API intermediates in China,Anhui Dexinjia Biopharm Co., Ltd founded in 2006, Except for the R&D center, our company has built a close cooperation relation with Chinese Academy of Sciences,
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Cas:498-45-3
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inquiryUnique advantages for Scopine Cas 498-45-3 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Applica
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:498-45-3
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inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s
Cas:498-45-3
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1 Factory price 2 High qualityDetails Product Name: Scopine Synonyms: SCOPINE;(1alpha,2beta,4beta,5alpha,7beta)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02.4]nonan-7-ol;SCOPINE, 97
Cas:498-45-3
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inquiryScopine Basic information Product Name: Scopine Synonyms: SCOPINE;(1alpha,2beta,4beta,5alpha,7beta)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02.4]nonan-7-ol;SCOPINE, 97+%;(1α,2β,4&b
Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:498-45-3
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryScopine Chemical Properties Melting point 73.0 to 77.0 °C Boiling point 281.3±40.0 °C(Predicted) density 1.284±0.06 g/cm3(Predicted) storage temp. Inert atmosphere,Store in freezer, under -20°C pka 14 +-.0
Scopine CAS: 498-45-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, ste
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Product Name: Scopine Synonyms: SCOPINE;(1alpha,2beta,4beta,5alpha,7beta)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02.4]nonan-7-ol;SCOPINE, 97+%;(1α,2β,4β,5α)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7β-ol;(1β,2&al
Cas:498-45-3
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Scopine Appearance:White to white crystal powder Storage:2-8°C Package:according to customers' requirements Application:API intermediates;Tiotropium Bromide Intermediates;Inhibitors Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by se
Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:498-45-3
Min.Order:10 Gram
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inquiryProduct name: Scopine CAS No.:498-45-3 Molecule Formula:C8H13NO2 Molecule Weight:155.19 Purity: 97% Package: 25kg/drum Description:White to off-white powder Manufacture Standards:Enterprise Standard TESTING ITEMS
Cas:498-45-3
Min.Order:1 Kilogram
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED
Cas:498-45-3
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:498-45-3
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inquiryscopolamine
scopine
Conditions | Yield |
---|---|
With 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine In toluene at 25℃; for 48h; | 99.3% |
Stage #1: scopolamine With sodium tetrahydroborate In ethanol at 0 - 20℃; for 24h; Stage #2: With hydrogenchloride In diethyl ether; ethanol at 20℃; for 24h; | 50% |
With ammonium chloride; ammonia at 30℃; |
Conditions | Yield |
---|---|
With sodium tetrahydroborate In ethanol at 20℃; Cooling with ice; | 87% |
scopine t-butyldimethylsilyl ether
scopine
Conditions | Yield |
---|---|
With tert-butyl-ammonium fluoride | 82% |
With tetrabutyl ammonium fluoride In tetrahydrofuran for 18h; | 81% |
scopine benzyl ether
scopine
Conditions | Yield |
---|---|
With hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal 1) EtOH, 5 atm, r.t, 12h; Yield given. Multistep reaction; |
scopine
Conditions | Yield |
---|---|
With NH3-NH4Cl-buffer solution | |
With bis-1-chloroethyl ether anschliessende Hydrolyse mit wss. Ba(OH)2 und dann mit wss. HCl; |
scopine
Conditions | Yield |
---|---|
With sodium hydroxide; acetone |
Tropilidenoxid
scopine
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: LiAlH4 / diethyl ether / 1 h 2: Me4N(1+)IO4(1-) / CH2Cl2 3: 1.) Me4N(1+)*IO4(1-), 2.) Imidazole, 3.) Na(Hg), Na3PO4, 4.) MCPBA 4: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, RT, 1.5 h 5: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C 6: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C 7: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating 8: 81 percent / TBAF / tetrahydrofuran / 18 h View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: Me4N(1+)IO4(1-) / CH2Cl2 2: 1.) Me4N(1+)*IO4(1-), 2.) Imidazole, 3.) Na(Hg), Na3PO4, 4.) MCPBA 3: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, RT, 1.5 h 4: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C 5: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C 6: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating 7: 81 percent / TBAF / tetrahydrofuran / 18 h View Scheme | |
Multi-step reaction with 9 steps 1: NaH / tetrahydrofuran / 15 h / 50 °C 2: 63 percent / LiCl, p-benzoquinone, glacial acetic acid / Pd(OAc)2 / acetic acid / 36 h 3: 96 percent / DIBAL / tetrahydrofuran; hexane / 0.75 h / 2 °C 4: 66 percent / Pd(PPh3)4 / acetonitrile / 4 h 5: 76 percent / LiCl, MsCl, 2,4,6-trimethylpyridine / dimethylformamide / 0 deg C to r.t., overnight 6: 86 percent / m-CPBA / CH2Cl2 / 48 h / Ambient temperature 7: 95 percent / K2CO3 / methanol / 56 h / Ambient temperature 8: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min 9: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: aq. CH3COOOH, Na2CO3 / CH2Cl2 / 3 h / 0 °C 2: LiAlH4 / diethyl ether / 1 h 3: Me4N(1+)IO4(1-) / CH2Cl2 4: 1.) Me4N(1+)*IO4(1-), 2.) Imidazole, 3.) Na(Hg), Na3PO4, 4.) MCPBA 5: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, RT, 1.5 h 6: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C 7: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C 8: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating 9: 81 percent / TBAF / tetrahydrofuran / 18 h View Scheme |
scopine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 68 percent / MCPBA / CH2Cl2 / 3 h / Ambient temperature 2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, RT, 1.5 h 3: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C 4: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C 5: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating 6: 81 percent / TBAF / tetrahydrofuran / 18 h View Scheme | |
Multi-step reaction with 6 steps 1: MCPBA / CH2Cl2 / 3 h / Ambient temperature 2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, RT, 1.5 h 3: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C 4: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C 5: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating 6: 81 percent / TBAF / tetrahydrofuran / 18 h View Scheme |
N-benzyloxycarbonyl-3α-<(t-butyldimethylsilyl)oxy>-6β,7β-epoxy-8-azabicyclo<3.2.1>octane
scopine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating 2: 81 percent / TBAF / tetrahydrofuran / 18 h View Scheme |
scopine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, RT, 1.5 h 2: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C 3: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C 4: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating 5: 81 percent / TBAF / tetrahydrofuran / 18 h View Scheme |
scopine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C 2: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating 3: 81 percent / TBAF / tetrahydrofuran / 18 h View Scheme |
scopine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C 2: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C 3: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating 4: 81 percent / TBAF / tetrahydrofuran / 18 h View Scheme |
scopine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 1.) Me4N(1+)*IO4(1-), 2.) Imidazole, 3.) Na(Hg), Na3PO4, 4.) MCPBA 2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, RT, 1.5 h 3: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C 4: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C 5: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating 6: 81 percent / TBAF / tetrahydrofuran / 18 h View Scheme |
6-(benzyloxy)-1,3-cycloheptadiene
scopine
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 63 percent / LiCl, p-benzoquinone, glacial acetic acid / Pd(OAc)2 / acetic acid / 36 h 2: 96 percent / DIBAL / tetrahydrofuran; hexane / 0.75 h / 2 °C 3: 66 percent / Pd(PPh3)4 / acetonitrile / 4 h 4: 76 percent / LiCl, MsCl, 2,4,6-trimethylpyridine / dimethylformamide / 0 deg C to r.t., overnight 5: 86 percent / m-CPBA / CH2Cl2 / 48 h / Ambient temperature 6: 95 percent / K2CO3 / methanol / 56 h / Ambient temperature 7: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min 8: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h View Scheme |
1β-hydroxy-4β-chloro-6α-(benzyloxy)-2-cycloheptene
scopine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 66 percent / Pd(PPh3)4 / acetonitrile / 4 h 2: 76 percent / LiCl, MsCl, 2,4,6-trimethylpyridine / dimethylformamide / 0 deg C to r.t., overnight 3: 86 percent / m-CPBA / CH2Cl2 / 48 h / Ambient temperature 4: 95 percent / K2CO3 / methanol / 56 h / Ambient temperature 5: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min 6: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h View Scheme |
1β-acetoxy-4β-chloro-6α-(benzyloxy)-2-cycloheptene
scopine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 96 percent / DIBAL / tetrahydrofuran; hexane / 0.75 h / 2 °C 2: 66 percent / Pd(PPh3)4 / acetonitrile / 4 h 3: 76 percent / LiCl, MsCl, 2,4,6-trimethylpyridine / dimethylformamide / 0 deg C to r.t., overnight 4: 86 percent / m-CPBA / CH2Cl2 / 48 h / Ambient temperature 5: 95 percent / K2CO3 / methanol / 56 h / Ambient temperature 6: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min 7: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h View Scheme |
1β-(p-toluenesulfonamido)-4-chloro-6α-(benzyloxy)-2-cycloheptene
scopine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 86 percent / m-CPBA / CH2Cl2 / 48 h / Ambient temperature 2: 95 percent / K2CO3 / methanol / 56 h / Ambient temperature 3: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min 4: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h View Scheme |
1β-(p-toluenesulfonamido)-2β,3β-epoxy-4α-chloro-6α-(benzyloxy)-2-cycloheptene
scopine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 95 percent / K2CO3 / methanol / 56 h / Ambient temperature 2: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min 3: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h View Scheme |
1β-(p-toluenesulfonamido)-4β-hydroxy-6α-(benzyloxy)-2-cycloheptene
scopine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 76 percent / LiCl, MsCl, 2,4,6-trimethylpyridine / dimethylformamide / 0 deg C to r.t., overnight 2: 86 percent / m-CPBA / CH2Cl2 / 48 h / Ambient temperature 3: 95 percent / K2CO3 / methanol / 56 h / Ambient temperature 4: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min 5: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h View Scheme |
3α-(benzyloxy)-6β,7β-epoxy-8-(p-toluenesulfonyl)-1β-azabicyclo<3.2.1>octane
scopine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min 2: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h View Scheme |
Conditions | Yield |
---|---|
With ruthenium trichloride; potassium metaperiodate; diperiodatocuprate(III) dihydrate; water; potassium nitrate; potassium hydroxide at 28℃; for 6h; Kinetics; Catalytic behavior; Concentration; Temperature; Inert atmosphere; |
scopine
methyl iodide
(1R,2R,4S,5S,7S)-7-hydroxy-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumiodide (N-methylscopinium)
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 48h; Inert atmosphere; | 85% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 16h; Product distribution / selectivity; | 83% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 16h; Reagent/catalyst; Solvent; Concentration; | 83% |
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h; Product distribution / selectivity; |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 4h; | 82.3% |
hydroxy-di-thiophen-2-yl-acetic acid methyl ester
scopine
N-demethyltiotropium
Conditions | Yield |
---|---|
With potassium tert-butylate; 1-butyl-3-methylimidazolium Tetrafluoroborate In tetrahydrofuran at 20℃; for 18h; Solvent; Concentration; Reagent/catalyst; Temperature; Time; Molecular sieve; | 73% |
Stage #1: hydroxy-di-thiophen-2-yl-acetic acid methyl ester; scopine at 70℃; under 210 Torr; for 1h; Stage #2: With sodium hydride at 70℃; under 210 Torr; for 3h; | 42% |
With sodium hydride In toluene; mineral oil at 90℃; for 2h; | 33% |
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 70℃; under 15.0015 Torr; for 19h; |
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at -35 - 20℃; | 67.9% |
hydroxy-di-thiophen-2-yl-acetic acid methyl ester
scopine
A
N-demethyltiotropium
Conditions | Yield |
---|---|
Stage #1: hydroxy-di-thiophen-2-yl-acetic acid methyl ester; scopine With sodium t-butanolate In tetrahydrofuran; toluene at 70 - 90℃; under 375.038 Torr; for 4.41667h; Inert atmosphere; Stage #2: With hydrogenchloride In dichloromethane; water Cooling with ice; Stage #3: With sodium carbonate In water Reagent/catalyst; Solvent; Time; Temperature; Pressure; Concentration; Overall yield = 37.2 g; | A 58% B 5.3 %Chromat. C 6.1 %Chromat. |
Stage #1: hydroxy-di-thiophen-2-yl-acetic acid methyl ester; scopine With potassium tert-butylate In toluene at 70 - 90℃; under 225.023 - 300.03 Torr; for 4.25h; Inert atmosphere; Stage #2: With hydrogenchloride In dichloromethane; water Cooling with ice; Stage #3: With sodium carbonate In water Reagent/catalyst; Temperature; Time; Overall yield = 0.82 g; | A 41% B 18.4 %Chromat. C 5.6 %Chromat. |
Stage #1: hydroxy-di-thiophen-2-yl-acetic acid methyl ester; scopine With sodium hydride In toluene; mineral oil at 70 - 90℃; under 225.023 - 300.03 Torr; for 4.25h; Inert atmosphere; Stage #2: With hydrogenchloride In water; toluene; mineral oil Cooling with ice; Stage #3: With sodium carbonate In water Overall yield = 1.01 g; | A 21% B 35.7 %Chromat. C 30.4 %Chromat. |
Conditions | Yield |
---|---|
In dichloromethane at 40℃; for 24h; | 47% |
hydroxy-di-thiophen-2-yl-acetic acid methyl ester
scopine
A
N-demethyltiotropium
Conditions | Yield |
---|---|
Stage #1: hydroxy-di-thiophen-2-yl-acetic acid methyl ester; scopine With sodium t-butanolate In toluene at 70 - 90℃; under 225.023 - 300.03 Torr; for 4.25h; Inert atmosphere; Stage #2: With hydrogenchloride In dichloromethane; water Cooling with ice; Stage #3: With sodium carbonate In water Time; Concentration; | A 33% B 26.3 %Chromat. |
Stage #1: hydroxy-di-thiophen-2-yl-acetic acid methyl ester; scopine With sodium methylate In toluene at 70 - 90℃; under 75.0075 - 225.023 Torr; for 5.25h; Inert atmosphere; Stage #2: With hydrogenchloride In water; toluene Cooling with ice; Stage #3: With sodium carbonate In water | A 11.6 %Chromat. B 57.3 %Chromat. |
Conditions | Yield |
---|---|
Stage #1: bis(trichloromethyl) carbonate; scopine In acetonitrile at 0 - 20℃; for 36h; Stage #2: 2-amino-5-fluorobiphenyl With pyridine at 60℃; for 24h; | 8% |
1-chloro-4-(diazo(phenyl)methyl)benzene
scopine
7t-(4-chloro-benzhydryloxy)-9-methyl-(1rN,2tH,4tH,5cN)-3-oxa-9-aza-tricyclo[3.3.1.02,4]nonane
Conditions | Yield |
---|---|
In benzene at 95 - 100℃; for 5.5h; |
diazodiphenylmethane
scopine
7t-benzhydryloxy-9-methyl-(1rN,2tH,4tH,5cN)-3-oxa-9-aza-tricyclo[3.3.1.02,4]nonane
Conditions | Yield |
---|---|
In benzene at 80 - 85℃; for 3h; |
scopine
Conditions | Yield |
---|---|
bei der Destillation; |
Conditions | Yield |
---|---|
at 50 - 60℃; |
Conditions | Yield |
---|---|
at 20℃; |
3-acetoxy-2-phenyl-propionyl chloride
scopine
scopine
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