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Anhui Dexinjia Biopharm Co., Ltd

As a leading and professional manufacturer of APIs and API intermediates in China,Anhui Dexinjia Biopharm Co., Ltd founded in 2006, Except for the R&D center, our company has built a close cooperation relation with Chinese Academy of Sciences,

Scopine

Cas:498-45-3

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Scopine supplier in China

Cas:498-45-3

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Scopine Cas 498-45-3 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Applica

High quality Scopine Cas498-45-3 with fast delivery

Cas:498-45-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Scopine

Cas:498-45-3

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Scopine 498-45-3 GMP Manufacturer

Cas:498-45-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s

Scopine Manufacturer/High quality/Best price/In stock

Cas:498-45-3

Min.Order:10 Gram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Scopine

Cas:498-45-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

1 Factory price 2 High qualityDetails Product Name: Scopine Synonyms: SCOPINE;(1alpha,2beta,4beta,5alpha,7beta)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02.4]nonan-7-ol;SCOPINE, 97

(1R,2R,4S,5S,7s)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-ol

Cas:498-45-3

Min.Order:20 Kilogram

FOB Price: $2000.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Scopine Basic information Product Name: Scopine Synonyms: SCOPINE;(1alpha,2beta,4beta,5alpha,7beta)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02.4]nonan-7-ol;SCOPINE, 97+%;(1α,2β,4&b

498-45-3

Cas:498-45-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Scopine

Cas:498-45-3

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

99% PureCAS 498-45-3 with competitive price

Cas:498-45-3

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Scopine

Cas:498-45-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

3-Oxa-9-azatricyclo[3.3.1.02,4]nonan-7-ol,9-methyl-, (1a,2b,4b,5a,7b)- 498-45-3

Cas:498-45-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Scopine Chemical Properties Melting point 73.0 to 77.0 °C Boiling point 281.3±40.0 °C(Predicted) density 1.284±0.06 g/cm3(Predicted) storage temp. Inert atmosphere,Store in freezer, under -20°C pka 14 +-.0

Scopine,

Cas:498-45-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Scopine CAS: 498-45-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, ste

Scopine CAS: 498-45-3

Cas:498-45-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Scopine

Cas:498-45-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Scopine Synonyms: SCOPINE;(1alpha,2beta,4beta,5alpha,7beta)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02.4]nonan-7-ol;SCOPINE, 97+%;(1α,2β,4β,5α)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7β-ol;(1β,2&al

Scopine Manufactory best quality

Cas:498-45-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Scopine

Cas:498-45-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Scopine

Cas:498-45-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Scopine

Cas:498-45-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Scopine Appearance:White to white crystal powder Storage:2-8°C Package:according to customers' requirements Application:API intermediates;Tiotropium Bromide Intermediates;Inhibitors Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by se

Scopine

Cas:498-45-3

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products Scopine

Cas:498-45-3

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Scopine supplier

Cas:498-45-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Scopine CAS No.:498-45-3 Molecule Formula:C8H13NO2 Molecule Weight:155.19 Purity: 97% Package: 25kg/drum Description:White to off-white powder Manufacture Standards:Enterprise Standard TESTING ITEMS

High Quality Scopine in stock

Cas:498-45-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Scopine

Cas:498-45-3

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

scopineCAS NO.: 498-45-3

Cas:498-45-3

Min.Order:1 Gram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Scopine

Cas:498-45-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

(1R,2R,4S,5S,7s)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-ol

Cas:498-45-3

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Scopine

Cas:498-45-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

498-45-3 CAS NO.498-45-3

Cas:498-45-3

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Synthetic route

Conditions
ConditionsYield
With 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine In toluene at 25℃; for 48h;99.3%
Stage #1: scopolamine With sodium tetrahydroborate In ethanol at 0 - 20℃; for 24h;
Stage #2: With hydrogenchloride In diethyl ether; ethanol at 20℃; for 24h;
50%
With ammonium chloride; ammonia at 30℃;
hyoscine hydrobromide
114-49-8

hyoscine hydrobromide

scopine
498-45-3

scopine

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol at 20℃; Cooling with ice;87%
scopine t-butyldimethylsilyl ether
182054-94-0

scopine t-butyldimethylsilyl ether

scopine
498-45-3

scopine

Conditions
ConditionsYield
With tert-butyl-ammonium fluoride82%
With tetrabutyl ammonium fluoride In tetrahydrofuran for 18h;81%
scopine benzyl ether
132622-34-5, 132697-33-7

scopine benzyl ether

scopine
498-45-3

scopine

Conditions
ConditionsYield
With hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal 1) EtOH, 5 atm, r.t, 12h; Yield given. Multistep reaction;
(-)-scopolamine

(-)-scopolamine

scopine
498-45-3

scopine

Conditions
ConditionsYield
With NH3-NH4Cl-buffer solution
With bis-1-chloroethyl ether anschliessende Hydrolyse mit wss. Ba(OH)2 und dann mit wss. HCl;
O-acetyl-scopine

O-acetyl-scopine

scopine
498-45-3

scopine

Conditions
ConditionsYield
With sodium hydroxide; acetone
Tropilidenoxid
33250-14-5

Tropilidenoxid

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: LiAlH4 / diethyl ether / 1 h
2: Me4N(1+)IO4(1-) / CH2Cl2
3: 1.) Me4N(1+)*IO4(1-), 2.) Imidazole, 3.) Na(Hg), Na3PO4, 4.) MCPBA
4: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, RT, 1.5 h
5: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C
6: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C
7: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating
8: 81 percent / TBAF / tetrahydrofuran / 18 h
View Scheme
cyclohepta-3,5-dien-1-ol
1121-63-7

cyclohepta-3,5-dien-1-ol

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: Me4N(1+)IO4(1-) / CH2Cl2
2: 1.) Me4N(1+)*IO4(1-), 2.) Imidazole, 3.) Na(Hg), Na3PO4, 4.) MCPBA
3: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, RT, 1.5 h
4: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C
5: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C
6: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating
7: 81 percent / TBAF / tetrahydrofuran / 18 h
View Scheme
Multi-step reaction with 9 steps
1: NaH / tetrahydrofuran / 15 h / 50 °C
2: 63 percent / LiCl, p-benzoquinone, glacial acetic acid / Pd(OAc)2 / acetic acid / 36 h
3: 96 percent / DIBAL / tetrahydrofuran; hexane / 0.75 h / 2 °C
4: 66 percent / Pd(PPh3)4 / acetonitrile / 4 h
5: 76 percent / LiCl, MsCl, 2,4,6-trimethylpyridine / dimethylformamide / 0 deg C to r.t., overnight
6: 86 percent / m-CPBA / CH2Cl2 / 48 h / Ambient temperature
7: 95 percent / K2CO3 / methanol / 56 h / Ambient temperature
8: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min
9: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h
View Scheme
Cyclohepta-1,3,5-triene
544-25-2

Cyclohepta-1,3,5-triene

norcaradiene-(2.4)

norcaradiene-(2.4)

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: aq. CH3COOOH, Na2CO3 / CH2Cl2 / 3 h / 0 °C
2: LiAlH4 / diethyl ether / 1 h
3: Me4N(1+)IO4(1-) / CH2Cl2
4: 1.) Me4N(1+)*IO4(1-), 2.) Imidazole, 3.) Na(Hg), Na3PO4, 4.) MCPBA
5: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, RT, 1.5 h
6: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C
7: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C
8: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating
9: 81 percent / TBAF / tetrahydrofuran / 18 h
View Scheme
1β-hydroxy-4β-<(benzyloxycarbonyl)amino>-6-<(t-butyldimethylsilyl)oxy>cyclohept-2-ene

1β-hydroxy-4β-<(benzyloxycarbonyl)amino>-6-<(t-butyldimethylsilyl)oxy>cyclohept-2-ene

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 68 percent / MCPBA / CH2Cl2 / 3 h / Ambient temperature
2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, RT, 1.5 h
3: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C
4: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C
5: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating
6: 81 percent / TBAF / tetrahydrofuran / 18 h
View Scheme
Multi-step reaction with 6 steps
1: MCPBA / CH2Cl2 / 3 h / Ambient temperature
2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, RT, 1.5 h
3: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C
4: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C
5: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating
6: 81 percent / TBAF / tetrahydrofuran / 18 h
View Scheme
N-benzyloxycarbonyl-3α-<(t-butyldimethylsilyl)oxy>-6β,7β-epoxy-8-azabicyclo<3.2.1>octane
182054-91-7

N-benzyloxycarbonyl-3α-<(t-butyldimethylsilyl)oxy>-6β,7β-epoxy-8-azabicyclo<3.2.1>octane

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating
2: 81 percent / TBAF / tetrahydrofuran / 18 h
View Scheme
1β-hydroxy-2β,3β-epoxy-4β-<(benzyloxycarbonyl)amino>-6α-<(t-butyldimethylsilyl)oxy>cycloheptane

1β-hydroxy-2β,3β-epoxy-4β-<(benzyloxycarbonyl)amino>-6α-<(t-butyldimethylsilyl)oxy>cycloheptane

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, RT, 1.5 h
2: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C
3: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C
4: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating
5: 81 percent / TBAF / tetrahydrofuran / 18 h
View Scheme
1α-chloro-2β,3β-epoxy-4β-<(benzyloxycarbonyl)amino>-6α-<(t-butyldimethylsilyl)oxy>cycloheptane

1α-chloro-2β,3β-epoxy-4β-<(benzyloxycarbonyl)amino>-6α-<(t-butyldimethylsilyl)oxy>cycloheptane

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C
2: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating
3: 81 percent / TBAF / tetrahydrofuran / 18 h
View Scheme
1β-<(p-toluenesulphonyl)oxy>-2β,3β-epoxy-4β-<(benzyloxycarbonyl)amino>-6α-<(t-butyldimethylsilyl)oxy>cycloheptane

1β-<(p-toluenesulphonyl)oxy>-2β,3β-epoxy-4β-<(benzyloxycarbonyl)amino>-6α-<(t-butyldimethylsilyl)oxy>cycloheptane

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C
2: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C
3: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating
4: 81 percent / TBAF / tetrahydrofuran / 18 h
View Scheme
N-benzyloxycarbonyl-3α-hydroxy-6-aza-7-oxabicyclo[3.2.2]non-8-ene

N-benzyloxycarbonyl-3α-hydroxy-6-aza-7-oxabicyclo[3.2.2]non-8-ene

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 1.) Me4N(1+)*IO4(1-), 2.) Imidazole, 3.) Na(Hg), Na3PO4, 4.) MCPBA
2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, RT, 1.5 h
3: 64 percent / LiCl / dimethylsulfoxide / 1.5 h / 55 °C
4: 82 percent / NaH / tetrahydrofuran; 1,2-dimethoxy-ethane / 3 h / 20 - 50 °C
5: 95 percent / LiAlH4 / diethyl ether / 2 h / Heating
6: 81 percent / TBAF / tetrahydrofuran / 18 h
View Scheme
6-(benzyloxy)-1,3-cycloheptadiene
115522-58-2

6-(benzyloxy)-1,3-cycloheptadiene

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 63 percent / LiCl, p-benzoquinone, glacial acetic acid / Pd(OAc)2 / acetic acid / 36 h
2: 96 percent / DIBAL / tetrahydrofuran; hexane / 0.75 h / 2 °C
3: 66 percent / Pd(PPh3)4 / acetonitrile / 4 h
4: 76 percent / LiCl, MsCl, 2,4,6-trimethylpyridine / dimethylformamide / 0 deg C to r.t., overnight
5: 86 percent / m-CPBA / CH2Cl2 / 48 h / Ambient temperature
6: 95 percent / K2CO3 / methanol / 56 h / Ambient temperature
7: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min
8: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h
View Scheme
1β-hydroxy-4β-chloro-6α-(benzyloxy)-2-cycloheptene
132622-29-8

1β-hydroxy-4β-chloro-6α-(benzyloxy)-2-cycloheptene

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 66 percent / Pd(PPh3)4 / acetonitrile / 4 h
2: 76 percent / LiCl, MsCl, 2,4,6-trimethylpyridine / dimethylformamide / 0 deg C to r.t., overnight
3: 86 percent / m-CPBA / CH2Cl2 / 48 h / Ambient temperature
4: 95 percent / K2CO3 / methanol / 56 h / Ambient temperature
5: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min
6: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h
View Scheme
1β-acetoxy-4β-chloro-6α-(benzyloxy)-2-cycloheptene
115522-57-1, 150338-86-6

1β-acetoxy-4β-chloro-6α-(benzyloxy)-2-cycloheptene

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 96 percent / DIBAL / tetrahydrofuran; hexane / 0.75 h / 2 °C
2: 66 percent / Pd(PPh3)4 / acetonitrile / 4 h
3: 76 percent / LiCl, MsCl, 2,4,6-trimethylpyridine / dimethylformamide / 0 deg C to r.t., overnight
4: 86 percent / m-CPBA / CH2Cl2 / 48 h / Ambient temperature
5: 95 percent / K2CO3 / methanol / 56 h / Ambient temperature
6: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min
7: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h
View Scheme
1β-(p-toluenesulfonamido)-4-chloro-6α-(benzyloxy)-2-cycloheptene
132622-31-2, 132697-30-4

1β-(p-toluenesulfonamido)-4-chloro-6α-(benzyloxy)-2-cycloheptene

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 86 percent / m-CPBA / CH2Cl2 / 48 h / Ambient temperature
2: 95 percent / K2CO3 / methanol / 56 h / Ambient temperature
3: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min
4: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h
View Scheme
1β-(p-toluenesulfonamido)-2β,3β-epoxy-4α-chloro-6α-(benzyloxy)-2-cycloheptene
132622-32-3

1β-(p-toluenesulfonamido)-2β,3β-epoxy-4α-chloro-6α-(benzyloxy)-2-cycloheptene

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 95 percent / K2CO3 / methanol / 56 h / Ambient temperature
2: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min
3: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h
View Scheme
1β-(p-toluenesulfonamido)-4β-hydroxy-6α-(benzyloxy)-2-cycloheptene
132622-30-1, 132697-31-5

1β-(p-toluenesulfonamido)-4β-hydroxy-6α-(benzyloxy)-2-cycloheptene

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 76 percent / LiCl, MsCl, 2,4,6-trimethylpyridine / dimethylformamide / 0 deg C to r.t., overnight
2: 86 percent / m-CPBA / CH2Cl2 / 48 h / Ambient temperature
3: 95 percent / K2CO3 / methanol / 56 h / Ambient temperature
4: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min
5: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h
View Scheme
3α-(benzyloxy)-6β,7β-epoxy-8-(p-toluenesulfonyl)-1β-azabicyclo<3.2.1>octane
132622-33-4, 132697-32-6

3α-(benzyloxy)-6β,7β-epoxy-8-(p-toluenesulfonyl)-1β-azabicyclo<3.2.1>octane

scopine
498-45-3

scopine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1) naphthalene, Na / 1) THF, -78 deg C, 30 min
2: 1) aq.2M HCl, H2, 2) 10percent aq. K2CO3 / 1) 10percent Pd/C / 1) EtOH, 5 atm, r.t, 12h
View Scheme
hyoscine-N-butyl bromide
149-64-4

hyoscine-N-butyl bromide

scopine
498-45-3

scopine

Conditions
ConditionsYield
With ruthenium trichloride; potassium metaperiodate; diperiodatocuprate(III) dihydrate; water; potassium nitrate; potassium hydroxide at 28℃; for 6h; Kinetics; Catalytic behavior; Concentration; Temperature; Inert atmosphere;
scopine
498-45-3

scopine

methyl iodide
74-88-4

methyl iodide

(1R,2R,4S,5S,7S)-7-hydroxy-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumiodide (N-methylscopinium)
21662-36-2

(1R,2R,4S,5S,7S)-7-hydroxy-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iumiodide (N-methylscopinium)

Conditions
ConditionsYield
In dichloromethane at 20℃; for 48h; Inert atmosphere;85%
2,2-di(thiophen-2-yl)acetic acid
4408-82-6

2,2-di(thiophen-2-yl)acetic acid

scopine
498-45-3

scopine

C18H19NO3S2
1336913-21-3

C18H19NO3S2

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 16h; Product distribution / selectivity;83%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 16h; Reagent/catalyst; Solvent; Concentration;83%
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h; Product distribution / selectivity;
scopine
498-45-3

scopine

chlorambucil
305-03-3

chlorambucil

C22H30Cl2N2O3

C22H30Cl2N2O3

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 4h;82.3%
hydroxy-di-thiophen-2-yl-acetic acid methyl ester
26447-85-8

hydroxy-di-thiophen-2-yl-acetic acid methyl ester

scopine
498-45-3

scopine

N-demethyltiotropium
136310-64-0

N-demethyltiotropium

Conditions
ConditionsYield
With potassium tert-butylate; 1-butyl-3-methylimidazolium Tetrafluoroborate In tetrahydrofuran at 20℃; for 18h; Solvent; Concentration; Reagent/catalyst; Temperature; Time; Molecular sieve;73%
Stage #1: hydroxy-di-thiophen-2-yl-acetic acid methyl ester; scopine at 70℃; under 210 Torr; for 1h;
Stage #2: With sodium hydride at 70℃; under 210 Torr; for 3h;
42%
With sodium hydride In toluene; mineral oil at 90℃; for 2h;33%
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 70℃; under 15.0015 Torr; for 19h;
benzoic acid
65-85-0

benzoic acid

scopine
498-45-3

scopine

(1R,2R,4S,5S,7r)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl benzoate

(1R,2R,4S,5S,7r)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl benzoate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at -35 - 20℃;67.9%
hydroxy-di-thiophen-2-yl-acetic acid methyl ester
26447-85-8

hydroxy-di-thiophen-2-yl-acetic acid methyl ester

scopine
498-45-3

scopine

A

N-demethyltiotropium
136310-64-0

N-demethyltiotropium

B

scopoline

scopoline

C

di-(2-thienyl)glycolic acid scopoline ester

di-(2-thienyl)glycolic acid scopoline ester

Conditions
ConditionsYield
Stage #1: hydroxy-di-thiophen-2-yl-acetic acid methyl ester; scopine With sodium t-butanolate In tetrahydrofuran; toluene at 70 - 90℃; under 375.038 Torr; for 4.41667h; Inert atmosphere;
Stage #2: With hydrogenchloride In dichloromethane; water Cooling with ice;
Stage #3: With sodium carbonate In water Reagent/catalyst; Solvent; Time; Temperature; Pressure; Concentration; Overall yield = 37.2 g;
A 58%
B 5.3 %Chromat.
C 6.1 %Chromat.
Stage #1: hydroxy-di-thiophen-2-yl-acetic acid methyl ester; scopine With potassium tert-butylate In toluene at 70 - 90℃; under 225.023 - 300.03 Torr; for 4.25h; Inert atmosphere;
Stage #2: With hydrogenchloride In dichloromethane; water Cooling with ice;
Stage #3: With sodium carbonate In water Reagent/catalyst; Temperature; Time; Overall yield = 0.82 g;
A 41%
B 18.4 %Chromat.
C 5.6 %Chromat.
Stage #1: hydroxy-di-thiophen-2-yl-acetic acid methyl ester; scopine With sodium hydride In toluene; mineral oil at 70 - 90℃; under 225.023 - 300.03 Torr; for 4.25h; Inert atmosphere;
Stage #2: With hydrogenchloride In water; toluene; mineral oil Cooling with ice;
Stage #3: With sodium carbonate In water Overall yield = 1.01 g;
A 21%
B 35.7 %Chromat.
C 30.4 %Chromat.
2,2-diphenylpropionyl chloride
40997-78-2

2,2-diphenylpropionyl chloride

scopine
498-45-3

scopine

scopine 2,2-diphenylpropionate

scopine 2,2-diphenylpropionate

Conditions
ConditionsYield
In dichloromethane at 40℃; for 24h;47%
hydroxy-di-thiophen-2-yl-acetic acid methyl ester
26447-85-8

hydroxy-di-thiophen-2-yl-acetic acid methyl ester

scopine
498-45-3

scopine

A

N-demethyltiotropium
136310-64-0

N-demethyltiotropium

B

scopoline

scopoline

Conditions
ConditionsYield
Stage #1: hydroxy-di-thiophen-2-yl-acetic acid methyl ester; scopine With sodium t-butanolate In toluene at 70 - 90℃; under 225.023 - 300.03 Torr; for 4.25h; Inert atmosphere;
Stage #2: With hydrogenchloride In dichloromethane; water Cooling with ice;
Stage #3: With sodium carbonate In water Time; Concentration;
A 33%
B 26.3 %Chromat.
Stage #1: hydroxy-di-thiophen-2-yl-acetic acid methyl ester; scopine With sodium methylate In toluene at 70 - 90℃; under 75.0075 - 225.023 Torr; for 5.25h; Inert atmosphere;
Stage #2: With hydrogenchloride In water; toluene Cooling with ice;
Stage #3: With sodium carbonate In water
A 11.6 %Chromat.
B 57.3 %Chromat.
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

2-amino-5-fluorobiphenyl
1717-22-2

2-amino-5-fluorobiphenyl

scopine
498-45-3

scopine

(1R,2R,4S,5S,7s,9r)-7-(((5-fluorobiphenyl-2-yl)carbamoyl)oxy)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium chloride

(1R,2R,4S,5S,7s,9r)-7-(((5-fluorobiphenyl-2-yl)carbamoyl)oxy)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium chloride

Conditions
ConditionsYield
Stage #1: bis(trichloromethyl) carbonate; scopine In acetonitrile at 0 - 20℃; for 36h;
Stage #2: 2-amino-5-fluorobiphenyl With pyridine at 60℃; for 24h;
8%
1-chloro-4-(diazo(phenyl)methyl)benzene
1140-33-6

1-chloro-4-(diazo(phenyl)methyl)benzene

scopine
498-45-3

scopine

7t-(4-chloro-benzhydryloxy)-9-methyl-(1rN,2tH,4tH,5cN)-3-oxa-9-aza-tricyclo[3.3.1.02,4]nonane
116603-25-9

7t-(4-chloro-benzhydryloxy)-9-methyl-(1rN,2tH,4tH,5cN)-3-oxa-9-aza-tricyclo[3.3.1.02,4]nonane

Conditions
ConditionsYield
In benzene at 95 - 100℃; for 5.5h;
diazodiphenylmethane
908093-98-1

diazodiphenylmethane

scopine
498-45-3

scopine

7t-benzhydryloxy-9-methyl-(1rN,2tH,4tH,5cN)-3-oxa-9-aza-tricyclo[3.3.1.02,4]nonane
112018-04-9

7t-benzhydryloxy-9-methyl-(1rN,2tH,4tH,5cN)-3-oxa-9-aza-tricyclo[3.3.1.02,4]nonane

Conditions
ConditionsYield
In benzene at 80 - 85℃; for 3h;
3-acetoxy-2-phenyl-propionyl chloride
14510-37-3

3-acetoxy-2-phenyl-propionyl chloride

nitrobenzene
98-95-3

nitrobenzene

scopine
498-45-3

scopine

(+-)-O-acetyl-scopolamine hydrochloride

(+-)-O-acetyl-scopolamine hydrochloride

pyridine
110-86-1

pyridine

scopine
498-45-3

scopine

CrO3

CrO3

A

6exo,7exo-epoxy-tropan-3-one
498-47-5

6exo,7exo-epoxy-tropan-3-one

B

(+-)-N-formyl-norscopolin

(+-)-N-formyl-norscopolin

scopine
498-45-3

scopine

dl-scopolin

dl-scopolin

Conditions
ConditionsYield
bei der Destillation;
scopine
498-45-3

scopine

Cr2O3-H2SO4

Cr2O3-H2SO4

dl-scopolin

dl-scopolin

Conditions
ConditionsYield
at 50 - 60℃;
scopine
498-45-3

scopine

n KOH-solution

n KOH-solution

dl-scopolin

dl-scopolin

Conditions
ConditionsYield
at 20℃;
3-acetoxy-2-phenyl-propionyl chloride
14510-37-3

3-acetoxy-2-phenyl-propionyl chloride

nitrobenzene
98-95-3

nitrobenzene

scopine
498-45-3

scopine

O-<3-acetoxy-2-phenyl-propionyl>-scopolamine hydrochloride

O-<3-acetoxy-2-phenyl-propionyl>-scopolamine hydrochloride

3-acetoxy-2-phenyl-propionyl chloride
14510-37-3

3-acetoxy-2-phenyl-propionyl chloride

scopine
498-45-3

scopine

A

O-acetyl-scopine hydrochloride

O-acetyl-scopine hydrochloride

B

O-<3-acetoxy-2-phenyl>-propionyl>-scopolamine hydrochloride

O-<3-acetoxy-2-phenyl>-propionyl>-scopolamine hydrochloride

scopine
498-45-3

scopine

salts of scopolin

salts of scopolin

chlorosulfonic acid
7790-94-5

chlorosulfonic acid

scopine
498-45-3

scopine

A

scopinesulfuric acid

scopinesulfuric acid

B

dl-scopolinsulfuric acid

dl-scopolinsulfuric acid

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