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Hebei Miheng Trading Co., Ltd.

Indometacin CAS 53-86-1 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 Prof

Indometacin CAS 53-86-1

Cas:53-86-1

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

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hangzhou verychem science and technology co.ltd

Product name: Indomethacin Cas No: 53-86-1 Spec: BP/EP Hangzhou Verychem Science And Technology Co. Ltd. was set up in year 2004, it’s a young but fast growing company. In the twelve years history, it invested

Indomethacin, manufacturer in China

Cas:53-86-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Anti-inflammatory analgesic drugs Indometacin CAS:53-86-1

Cas:53-86-1

Min.Order:1 Kilogram

FOB Price: $42.0 / 46.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Indometacin/ LIDE PHARMA- Factory supply / Best price

Cas:53-86-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Indometacin Manufacturer/High quality/Best price/In stock

Cas:53-86-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up GMP DMF Indometacin 53-86-1

Cas:53-86-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Kono Chem Co.,Ltd

High quality raw material Indomethacin Description: Indomethacin CAS No.: 53-86-1 MF: C19H15ClNO4 EINECS No.: 200-186-5 Indomethacin, an antiinflammatory agent, inhibits Cox-1 and Cox-2 (cyclooxygenases) w

CAS:53-86-1 Indometacin

Cas:53-86-1

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

ndomethacin API,99% purity

Cas:53-86-1

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Indometacin Cas 53-86-1 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or yellow crystalline powder Storage:Store at RT Package:25kg/drum

Factory high quality Indometacin Cas 53-86-1 with low price and fast delivery

Cas:53-86-1

Min.Order:25 Kilogram

FOB Price: $30.0 / 32.0

Type:Trading Company

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Indomethacin manufacturer with low price

Cas:53-86-1

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Indometacin

Cas:53-86-1

Min.Order:1

Negotiable

Type:Other

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shanghai Tauto Biotech Co., Ltd

20-year experience in Phytochemicals Each product has passed very strict tests (NMR\MS\HPLC) Agents in 13 countries Certified by ISO 9001:2008 quality management system Leader Supplier of Botanical Reference Materials in China 3000 kinds of

Indomethacin

Cas:53-86-1

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Indometacin 53-86-1 ISO Producer

Cas:53-86-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Anhui Dexinjia Biopharm Co., Ltd

As a leading and professional manufacturer of APIs and API intermediates in China,Anhui Dexinjia Biopharm Co., Ltd founded in 2006, Except for the R&D center, our company has built a close cooperation relation with Chinese Academy of Sciences,

Indometacin

Cas:53-86-1

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Chengdu Lemeitian Pharmaceutical Technology Co,. Ltd

ADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,

Indomethacin

Cas:53-86-1

Min.Order:10 Metric Ton

Negotiable

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Indomethacin

Cas:53-86-1

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Chemwill Asia co.,Ltd is one of the leading manufacturer in CHINA.Our main production base is located in Xuzhou industry park. We produce a wide range of organics including Active pharmaceutical ingredients(APIs), V

Indometacin

Cas:53-86-1

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Indometacin CAS NO: 53-86-1 Grade:Medical scientific research and export Molecular formula:C19H16ClNO4 Molecular weight: 53-86-1 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Dat

Indometacin/ CAS:53-86-1 / raw material/ high-quality

Cas:53-86-1

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Indometacin CAS 53-86-1

Cas:53-86-1

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 53-86-1 with best quality

Cas:53-86-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

ndomethacin API,99% purity 53-86-1

Cas:53-86-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Antimex Chemical Limied

buy 53-86-1 98%MIN supplier As 53-86-1 factory and 53-86-1 supplier,the company has been strictly controllingproduct quality and striving their factory to achieve 53-86-1 98%MIN and low price,we already have rich experienceand understanding

buy 53-86-1 98%MIN supplier

Cas:53-86-1

Min.Order:1 Gram

FOB Price: $15.0

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Name Indometacin Synonyms 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid Molecular Formula C19H16ClNO4

Indomethacin

Cas:53-86-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-ylacetic acidCAS NO.:53-86-1

Cas:53-86-1

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White to off-white powder Storage:ln stock Package:25kg/Barrel Application:Anti-inflammatory, antipyretic effect is obvious, mainly used for rheumatic arthritis, ankylosing photospondylitis, osteoarthritis, etc. that are not easy to toler

Cheap Price Ready Stock Indometacin

Cas:53-86-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

99%min Indometacin 53-86-1 Anti-inflammatory Analgesics

Cas:53-86-1

Min.Order:10 Gram

Negotiable

Type:Other

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Hefei TNJ chemical industry co.,ltd

We are one of the domestic largest manufacturers of API; We are always supplier of products with higher quality and at more competitive price; We are supplier of safe and ecofriendly products ; We provide stable supply and efficient servic

Manufacturer of Indometacin at Factory Price

Cas:53-86-1

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exporting

Indometacin [53-86-1]

Cas:53-86-1

Min.Order:1 Gram

Negotiable

Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Pharmaceutical Grade Analgesic Anti-Inflammatory Indometacin Material Pure Indometacin

Cas:53-86-1

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate

high quality Indometacin99%

Cas:53-86-1

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Lab/Research institutions

inquiry

Synthetic route

indomethacin ethyl ester
16401-99-3

indomethacin ethyl ester

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
With sodium hydroxide In methanol; water for 1h; Reflux;99%
With lithium hydroxide monohydrate In water at 25℃; for 6h;657 mg
5-Methoxy-2-methylindole-3-acetic acid
2882-15-7

5-Methoxy-2-methylindole-3-acetic acid

4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
Stage #1: 5-Methoxy-2-methylindole-3-acetic acid With potassium tert-butylate In tetrahydrofuran at -78℃; for 1h; Large scale;
Stage #2: 4-chloro-benzoyl chloride In tetrahydrofuran at 20℃; for 16h; Large scale;
97%
Stage #1: 5-Methoxy-2-methylindole-3-acetic acid With potassium tert-butylate In tetrahydrofuran at -78℃; for 1h;
Stage #2: 4-chloro-benzoyl chloride In tetrahydrofuran at 20℃; for 16h;
95%
With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hexamethylsilazane 1.) THF; Multistep reaction;
4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

ethyl 2-(5-methoxy-2-methyl-1H-indol-3-yl)acetate
17536-38-8

ethyl 2-(5-methoxy-2-methyl-1H-indol-3-yl)acetate

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
Stage #1: ethyl 2-(5-methoxy-2-methyl-1H-indol-3-yl)acetate With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.333333h; Inert atmosphere;
Stage #2: 4-chloro-benzoyl chloride In tetrahydrofuran at 25℃; for 10h; Inert atmosphere;
Stage #3: With lithium hydroxide monohydrate; water In tetrahydrofuran at 25℃; for 6h; Inert atmosphere;
92%
<1-(4-chlorobenzoyl)-2-methyl-5-methoxyindol-3-yl>acetaldehyde
24438-49-1

<1-(4-chlorobenzoyl)-2-methyl-5-methoxyindol-3-yl>acetaldehyde

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
With N-hydroxyphthalimide; oxygen In acetonitrile at 80℃; for 30h; Schlenk technique;91%
With N-hydroxyphthalimide; oxygen In acetonitrile at 30℃; under 760.051 Torr; for 3h; Schlenk technique;91%
With sodium chlorite; sodium dihydrogenphosphate In tetrahydrofuran; water; tert-butyl alcohol at 20℃; for 0.5h; Schlenk technique;78%
With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene In tetrahydrofuran; water; tert-butyl alcohol at 20℃; for 0.5h;28.4 mg
2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid benzyl ester
26001-79-6

2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid benzyl ester

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In ethyl acetate at 20℃; for 0.666667h;84%
With palladium 10% on activated carbon; hydrogen In ethyl acetate
With 10% Pd/C; hydrogen In ethyl acetate
indomethacin methyl ester
1601-18-9

indomethacin methyl ester

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
With pyridine; lithium iodide for 20h; Reflux;84%
Stage #1: indomethacin methyl ester With pyridine; lithium iodide for 20h; Reflux;
Stage #2: With hydrogenchloride; water at 0℃;
83%
With pyridine; lithium iodide for 20h; Reflux;83%
acemetacin tert-butyl ester
75302-98-6

acemetacin tert-butyl ester

A

C20H18ClNO3

C20H18ClNO3

B

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
With pyridine; iodine; aluminium In acetonitrile at 80℃; for 18h; chemoselective reaction;A 20%
B 70%
sodium 2-(4-chlorobenzoyl)-2-(4-methoxyphenyl)-1-hydrazosulfonate

sodium 2-(4-chlorobenzoyl)-2-(4-methoxyphenyl)-1-hydrazosulfonate

levulinic acid
123-76-2

levulinic acid

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
With formic acid In acetic acid for 6h; Heating;66%
acemetacin tert-butyl ester
75302-98-6

acemetacin tert-butyl ester

A

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

B

acemetacin
53164-05-9

acemetacin

Conditions
ConditionsYield
With iodine; aluminium In acetonitrile at 20℃; for 6h; chemoselective reaction;A 30%
B 66%
5-methyl-2-furanone
591-12-8

5-methyl-2-furanone

N1-(4-chlorobenzoyl)-4-methoxyphenylhydrazine
16390-07-1

N1-(4-chlorobenzoyl)-4-methoxyphenylhydrazine

A

5-Methoxy-2-methylindole-3-acetic acid
2882-15-7

5-Methoxy-2-methylindole-3-acetic acid

B

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
With sulfuric acid In acetonitrile for 24h; Fischer indole reaction; Heating;A n/a
B 65%
4-methoxyphenylhydrazine hydrochloride
19501-58-7

4-methoxyphenylhydrazine hydrochloride

4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

levulinic acid
123-76-2

levulinic acid

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
Stage #1: 4-methoxyphenylhydrazine hydrochloride With aldehyde resin; triethylamine In dichloromethane at 45℃;
Stage #2: 4-chloro-benzoyl chloride With pyridine at 80℃;
Stage #3: levulinic acid With trifluoroacetic acid In 1,2-dichloro-ethane at 70℃;
63%
Stage #1: 4-methoxyphenylhydrazine hydrochloride With polystyrene aldehyde resin; triethylamine In 1,2-dichloro-ethane at 45℃;
Stage #2: 4-chloro-benzoyl chloride With pyridine at 80℃;
Stage #3: levulinic acid With trifluoroacetic acid In 1,2-dichloro-ethane at 70℃;
1-(4-Chlorbenzoyl)-5-methoxy-2-methyl-1H-indolyl-3-essigsaeure-2-oxo-propylester
137138-23-9

1-(4-Chlorbenzoyl)-5-methoxy-2-methyl-1H-indolyl-3-essigsaeure-2-oxo-propylester

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
With buffer pH 8.0 In 1,4-dioxane; acetonitrile at 57℃; half-life time of hydrolysis at different pH;
2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetoxy]-2'-hydroxy-diethyloxide
78458-11-4

2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetoxy]-2'-hydroxy-diethyloxide

A

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

B

diethylene glycol
111-46-6

diethylene glycol

Conditions
ConditionsYield
With isotonic phosphate buffer at 32℃; chemical and enzymatic stability; other temperature and reagents, other pH; other olygoethylene derivatives as substrates;
(1,3-dioxo-2,3-dihydro-1H-2-isoindolyl)methyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-3-indolyl]acetate

(1,3-dioxo-2,3-dihydro-1H-2-isoindolyl)methyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-3-indolyl]acetate

A

phthalimide
136918-14-4

phthalimide

B

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
With phosphate buffer pH 7.4 In 1,4-dioxane; water at 37℃; for 6h; Rate constant; var. of pH, also in rabbit plasma;
4‐formylphenyl 2‐(1‐(4‐chlorobenzoyl)‐5‐methoxy‐2‐methyl‐1H‐indol‐3‐yl)acetate

4‐formylphenyl 2‐(1‐(4‐chlorobenzoyl)‐5‐methoxy‐2‐methyl‐1H‐indol‐3‐yl)acetate

A

4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

B

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
With water In 1,4-dioxane at 37℃; Rate constant; t1/2; also without alkali;
[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2-formyl-phenyl ester

[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2-formyl-phenyl ester

A

salicylaldehyde
90-02-8

salicylaldehyde

B

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
With water In 1,4-dioxane at 27℃; Kinetics; Thermodynamic data; other temp.; ΔH (excit.), ΔS (excit.); t1/2; also without alkali;
[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2,5-dioxo-pyrrolidin-1-ylmethyl ester
1026091-18-8

[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2,5-dioxo-pyrrolidin-1-ylmethyl ester

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
With Tween 80; potassium chloride In phosphate buffer at 37℃; pH=7.4; Kinetics; Further Variations:; pH-values; also in 80 percent human plasma or 10 percent rat liver homogenate; Hydrolysis;
[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2,3-dioxo-2,3-dihydro-indol-1-ylmethyl ester
1026676-65-2

[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2,3-dioxo-2,3-dihydro-indol-1-ylmethyl ester

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
With Tween 80; potassium chloride In phosphate buffer at 37℃; pH=7.4; Kinetics; Further Variations:; pH-values; also in 80 percent human plasma or 10 percent rat liver homogenate; Hydrolysis;
acemetacin
53164-05-9

acemetacin

A

5-Methoxy-2-methylindole-3-acetic acid
2882-15-7

5-Methoxy-2-methylindole-3-acetic acid

B

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

C

5-methoxy-2-methylindol-3-yl acetic acid carboxymethyl ester

5-methoxy-2-methylindol-3-yl acetic acid carboxymethyl ester

D

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
In water at 30℃; Kinetics; Further Variations:; pH-values; Temperatures;
C23H20ClN3O4

C23H20ClN3O4

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
With water In acetonitrile at 39℃; pH=7.1; Kinetics;
1-(4-Chlorbenzoyl)-5-methoxy-2-methyl-3-indolylessigsaeure-(2-diethylamino)ethylester
78667-03-5

1-(4-Chlorbenzoyl)-5-methoxy-2-methyl-3-indolylessigsaeure-(2-diethylamino)ethylester

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
With pooled human serum at 37℃; Kinetics;
[2-(1-pyrrolidino)]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate

[2-(1-pyrrolidino)]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
With pooled human serum at 37℃; Kinetics;
[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid 2-piperidin-1-yl-ethyl ester

[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid 2-piperidin-1-yl-ethyl ester

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
With pooled human serum at 37℃; Kinetics;
[2-(4-morpholino)]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate

[2-(4-morpholino)]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
With pooled human serum at 37℃; Kinetics;
1-(4-Chlorbenzoyl)-5-methoxy-2-methyl-3-indolylessigsaeure-(2-dimethylamino)ethylester
76812-37-8

1-(4-Chlorbenzoyl)-5-methoxy-2-methyl-3-indolylessigsaeure-(2-dimethylamino)ethylester

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
With pooled human serum at 37℃; Kinetics;
sodium 2-(4-methoxyphenyl)diazene-1-sulfonate
5354-81-4

sodium 2-(4-methoxyphenyl)diazene-1-sulfonate

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 75 percent / Zn; aq. AcOH / 4 h / 20 °C
2: 88 percent / AcONa / acetic acid / 6 h
3: 66 percent / HCOOH / acetic acid / 6 h / Heating
View Scheme
4-methoxy-aniline
104-94-9

4-methoxy-aniline

4-[Ph2(AcO)2Bi]-C6H4-OCH2-polystyrene cross-linked with divinylbenzene

4-[Ph2(AcO)2Bi]-C6H4-OCH2-polystyrene cross-linked with divinylbenzene

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: aq. HCl; NaNO2 / 0.5 h / -5 - 0 °C
1.2: 38 g / aq. Na2SO3; NaOH / 0.5 h / 5 °C
2.1: 75 percent / Zn; aq. AcOH / 4 h / 20 °C
3.1: 88 percent / AcONa / acetic acid / 6 h
4.1: 66 percent / HCOOH / acetic acid / 6 h / Heating
View Scheme
4-Methoxyphenylhydrazin-β-sulfonsaeure Natriumsalz

4-Methoxyphenylhydrazin-β-sulfonsaeure Natriumsalz

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 88 percent / AcONa / acetic acid / 6 h
2: 66 percent / HCOOH / acetic acid / 6 h / Heating
View Scheme
N-(4-chlorobenzoyl)-2-iodo-4-methoxyaniline
873657-14-8

N-(4-chlorobenzoyl)-2-iodo-4-methoxyaniline

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 54 percent / tri-2-furylphosphine; CuI; Pd2(dba)3 / Bu4NCl / dimethylformamide / 2 h / 20 °C
2: TBAF; AcOH / tetrahydrofuran / 5 h / 20 °C
3: IBX / ethyl acetate / 2 h / 80 °C
4: 28.4 mg / 2-methyl-2-butene; NaH2PO4*H2O; NaClO2 / 2-methyl-propan-2-ol; tetrahydrofuran; H2O / 0.5 h / 20 °C
View Scheme
1-Adamantanamine
768-94-5

1-Adamantanamine

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

C19H16ClNO4*C10H17N

C19H16ClNO4*C10H17N

Conditions
ConditionsYield
In methanol at 20℃;100%
tert-butyl (2,2-difluoro-3-hydroxypropyl)carbamate

tert-butyl (2,2-difluoro-3-hydroxypropyl)carbamate

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

C27H29ClF2N2O6

C27H29ClF2N2O6

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃;100%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid 2,5-dioxopyrrolidin-1-yl ester
104425-42-5

[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid 2,5-dioxopyrrolidin-1-yl ester

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 3h;99%
With dicyclohexyl-carbodiimide In DMF (N,N-dimethyl-formamide); dichloromethane at 0 - 20℃;92%
With dicyclohexyl-carbodiimide In 1,4-dioxane for 8h; Ambient temperature;91%
4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

4‐formylphenyl 2‐(1‐(4‐chlorobenzoyl)‐5‐methoxy‐2‐methyl‐1H‐indol‐3‐yl)acetate

4‐formylphenyl 2‐(1‐(4‐chlorobenzoyl)‐5‐methoxy‐2‐methyl‐1H‐indol‐3‐yl)acetate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h;99%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;28%
With pyridine; toluene-4-sulfonic acid; acetic acid; dicyclohexyl-carbodiimide 1.) r.t., 24 h, 2.) 4 deg C, 24 h; Yield given. Multistep reaction;
[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Indomethacin amide
6264-33-1

Indomethacin amide

Conditions
ConditionsYield
Stage #1: [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid With oxalyl dichloride In dichloromethane at 0 - 20℃; for 1h; Inert atmosphere;
Stage #2: With ammonium hydroxide In tetrahydrofuran at 0℃; for 1h;
99%
With N-cyclohexyl-N'-(2-morpholinoethyl)carbodiimide para-toluenesulfonate; ammonia; benzotriazol-1-ol In 1,4-dioxane; DMF (N,N-dimethyl-formamide); ethyl acetate at 0 - 20℃;95%
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonium chloride; benzotriazol-1-ol In N,N-dimethyl-formamide at 20℃; Substitution;84%
n-Pent-4-enyl alcohol
821-09-0

n-Pent-4-enyl alcohol

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

pent-4-en-1-yl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate
1019777-27-5

pent-4-en-1-yl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 24h; Inert atmosphere;99%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 40h; Inert atmosphere;87%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 48h; Inert atmosphere;84%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 12h; Schlenk technique; Inert atmosphere;30%
[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

(4-chlorophenyl)(3-(2-hydroxyethyl)-5-methoxy-2-methyl-1H-indol-1-yl)methanone
16130-32-8

(4-chlorophenyl)(3-(2-hydroxyethyl)-5-methoxy-2-methyl-1H-indol-1-yl)methanone

Conditions
ConditionsYield
With borane-THF In tetrahydrofuran at 5℃; for 18h;98%
With dimethylsulfide borane complex In tetrahydrofuran at 20℃; for 22h; Cooling with ice;91%
With dimethylsulfide borane complex In tetrahydrofuran at 0 - 20℃; for 12h; Inert atmosphere;90%
2,2,2,-trichloroethoxycarbonyl azide

2,2,2,-trichloroethoxycarbonyl azide

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

2,2,2-trichloroethyl-((1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-yl)methyl)carbamic acid ester

2,2,2-trichloroethyl-((1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-yl)methyl)carbamic acid ester

Conditions
ConditionsYield
With dmap; copper diacetate In acetonitrile at 80℃; for 0.25h; Schlenk technique; Sealed tube;98%
With dmap; copper diacetate In acetonitrile at 80℃; for 3h; Curtius Rearrangement; Inert atmosphere;93%
N-tert-butoxycarbonyl-O-diethylcarbamoyl-N-bromopropylhydroxylamine

N-tert-butoxycarbonyl-O-diethylcarbamoyl-N-bromopropylhydroxylamine

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

3-((tert-butoxycarbonyl)((diethylcarbamoyl)oxy)amino)propyl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate

3-((tert-butoxycarbonyl)((diethylcarbamoyl)oxy)amino)propyl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 60℃;98%
ethanol
64-17-5

ethanol

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

indomethacin ethyl ester
16401-99-3

indomethacin ethyl ester

Conditions
ConditionsYield
With dmap; diisopropyl-carbodiimide In dichloromethane at 20℃; for 16h;97%
Stage #1: [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid With oxalyl dichloride In dichloromethane at 20℃; for 2h;
Stage #2: ethanol With triethylamine In dichloromethane for 0.5h;
93%
With toluene-4-sulfonic acid In toluene at 140℃; for 6h; Dean-Stark;90%
(E)-hept-2-en-1-ol
33467-76-4

(E)-hept-2-en-1-ol

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid hept-2-enyl ester

[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid hept-2-enyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 5h; Esterification;97%
[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

benzylamine
100-46-9

benzylamine

N-benzyl-2-[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetamide
572875-44-6

N-benzyl-2-[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetamide

Conditions
ConditionsYield
With zirconium(IV) chloride In tetrahydrofuran at 70℃; for 24h; Molecular sieve; Inert atmosphere;97%
With (2-iodo-4',5-dimethoxy-[1,1'-biphenyl]-3-yl)boronic acid In dichloromethane at 24 - 25℃; for 6h; Molecular sieve;94%
With (2-bromophenyl)boronic acid In dichloromethane at 25℃; for 48h; Molecular sieve;93%
With bis(cyclopentadienyl)titanium dichloride In tetrahydrofuran at 70℃; for 24h; Molecular sieve; Sealed tube; Inert atmosphere;85%
2-(Trimethylsilyl)ethanol
2916-68-9

2-(Trimethylsilyl)ethanol

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

2-(trimethylsilyl)ethyl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate
1224508-94-4

2-(trimethylsilyl)ethyl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 25℃; Inert atmosphere;97%
isopropyloxycarbonyloxymethyl iodide
258841-42-8

isopropyloxycarbonyloxymethyl iodide

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

[(1-methyl)ethoxycarbonyloxy]methyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetate
1268602-80-7

[(1-methyl)ethoxycarbonyloxy]methyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetate

Conditions
ConditionsYield
Stage #1: [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid With N,N,N',N'-tetramethylguanidine In N,N-dimethyl acetamide at -15℃; Inert atmosphere;
Stage #2: isopropyloxycarbonyloxymethyl iodide In N,N-dimethyl acetamide at -15℃; Inert atmosphere;
96.6%
[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetyl chloride
20357-37-3

1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetyl chloride

Conditions
ConditionsYield
With thionyl chloride In benzene at 65 - 70℃; for 1h;96.5%
With oxalyl dichloride In dichloromethane at 0 - 20℃; for 3.5h;96%
With oxalyl dichloride In dichloromethane at 20℃; for 8h; Inert atmosphere;96%
2-Butoxyethanol
111-76-2

2-Butoxyethanol

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2-butoxy-ethyl ester

[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2-butoxy-ethyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 5h; Esterification;96%
cyclohexylethan-1-ol
4442-79-9

cyclohexylethan-1-ol

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2-cyclohexyl-ethyl ester

[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2-cyclohexyl-ethyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 5h; Esterification;96%
3,3-dimethylbutanol
624-95-3

3,3-dimethylbutanol

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

3,3-dimethylbutyl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate
1224508-90-0

3,3-dimethylbutyl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate

Conditions
ConditionsYield
With 3-{[(ethylimino)methylene]-amino}-N,N,N-trimethyl-1-propanaminium iodide; dmap In dichloromethane at 0 - 20℃; Inert atmosphere;96%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 25℃; Inert atmosphere;96%
1-methylbutylzinc bromide

1-methylbutylzinc bromide

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

2-(5-methoxy-2-methyl-1-(4-(pentan-2-yl)benzoyl)-1H-indol-3-yl)acetic acid

2-(5-methoxy-2-methyl-1-(4-(pentan-2-yl)benzoyl)-1H-indol-3-yl)acetic acid

Conditions
ConditionsYield
Stage #1: [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid With C40H55Cl5N3Pd In toluene at 0℃; for 0.0833333h; Negishi Coupling; Inert atmosphere; Cooling with ice;
Stage #2: 1-methylbutylzinc bromide In tetrahydrofuran; toluene at 23℃; for 2h; Inert atmosphere;
96%
[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

Cyclopropylamine
765-30-0

Cyclopropylamine

2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-N-cyclopropylacetamide

2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-N-cyclopropylacetamide

Conditions
ConditionsYield
Stage #1: [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran for 2h;
Stage #2: Cyclopropylamine In tetrahydrofuran at 20℃; for 2h;
96%
[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

syringic aldehyde
134-96-3

syringic aldehyde

C28H24ClNO7

C28H24ClNO7

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In chloroform at 20℃; Steglich Esterification; Inert atmosphere;96%
8-Bromo-1-octene
2695-48-9

8-Bromo-1-octene

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

oct-7-en-1-yl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate

oct-7-en-1-yl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 4h; Inert atmosphere;96%
tert-Butyl chloroacetate
107-59-5

tert-Butyl chloroacetate

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

acemetacin tert-butyl ester
75302-98-6

acemetacin tert-butyl ester

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; sodium carbonate In toluene at 75℃; for 45h; Large scale;95.7%
iodomethyl pivaloate
53064-79-2

iodomethyl pivaloate

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

pivaloyloxymethyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetate
99199-42-5

pivaloyloxymethyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetate

Conditions
ConditionsYield
Stage #1: [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid With N,N,N',N'-tetramethylguanidine In N,N-dimethyl acetamide at -10 - 20℃; Inert atmosphere;
Stage #2: iodomethyl pivaloate In N,N-dimethyl acetamide at -20 - -15℃;
95.5%
4-Fluorophenol
371-41-5

4-Fluorophenol

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 4-fluoro-phenyl ester

[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 4-fluoro-phenyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 5h; Esterification;95%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 24h; Inert atmosphere;
2-phenylethanol
60-12-8

2-phenylethanol

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

phenethyl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate
63170-54-7

phenethyl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 5h; Esterification;95%
With C10H10Zr(2+)*2CF3O3S(1-)*C4H8O at 80℃; for 24h; Sealed tube;70%
[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide
15992-10-6

2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide

Conditions
ConditionsYield
Stage #1: [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid With chloroformic acid ethyl ester
Stage #2: With ammonium hydroxide; sodium hydroxide
95%
Stage #1: [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid With 4-methyl-morpholine; chloroformic acid ethyl ester In tetrahydrofuran at -10℃; for 0.5h;
Stage #2: With ammonium hydroxide In tetrahydrofuran at 20℃; for 3h;
Stage #3: With water; sodium hydroxide In tetrahydrofuran
88%
Multi-step reaction with 3 steps
1.1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h / -10 °C
1.2: 0.5 h
2.1: ammonium hydroxide / tetrahydrofuran / 3 h / 20 °C
3.1: sodium hydroxide / tetrahydrofuran
View Scheme
O-<3-Hydroxypropyl>hydroxylamine
343925-76-8

O-<3-Hydroxypropyl>hydroxylamine

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methylindol-3-yl}-N-(3-hydroxypropoxy)acetamide

2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methylindol-3-yl}-N-(3-hydroxypropoxy)acetamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃;95%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃;95%
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