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Synthetic route

ethyleneimine
151-56-4

ethyleneimine

N,N',N''-triethylenephosphoramide
545-55-1

N,N',N''-triethylenephosphoramide

Conditions
ConditionsYield
With ammonia; trichlorophosphate; benzene
With triethylamine; trichlorophosphate; benzene
Thiotepa
52-24-4

Thiotepa

A

N,N',N''-triethylenephosphoramide
545-55-1

N,N',N''-triethylenephosphoramide

B

C6H15Cl3N3OP
27780-83-2

C6H15Cl3N3OP

C

C6H15Cl3N3PS
93598-04-0

C6H15Cl3N3PS

D

C6H13ClN3OP
118694-55-6

C6H13ClN3OP

E

C6H13ClN3PS
90877-51-3

C6H13ClN3PS

F

C6H14Cl2N3PS
93598-03-9

C6H14Cl2N3PS

Conditions
ConditionsYield
In hydrogenchloride at 37℃; for 1h; Product distribution; different concentration of acid;
N,N',N''-triethylenephosphoramide
545-55-1

N,N',N''-triethylenephosphoramide

C6H18N3OPS3
13884-65-6

C6H18N3OPS3

Conditions
ConditionsYield
With hydrogenchloride; lithium thiophosphate powder In water; N,N-dimethyl-formamide at 25℃;92%
N,N',N''-triethylenephosphoramide
545-55-1

N,N',N''-triethylenephosphoramide

C6H15N3O10P4S3(6-)*6Li(1+)
83822-74-6

C6H15N3O10P4S3(6-)*6Li(1+)

Conditions
ConditionsYield
With hydrogenchloride; lithium thiophosphate powder In water for 0.333333h; Ambient temperature;62%
N,N',N''-triethylenephosphoramide
545-55-1

N,N',N''-triethylenephosphoramide

C6H15Br3N3OP
57856-86-7

C6H15Br3N3OP

Conditions
ConditionsYield
With hydrogen bromide Ambient temperature;
N,N',N''-triethylenephosphoramide
545-55-1

N,N',N''-triethylenephosphoramide

C6H21N3O10P4S3

C6H21N3O10P4S3

Conditions
ConditionsYield
With hydrogenchloride; trisodium thiophosphate Ambient temperature;

Raw Materials

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