Product Description Product website: http://www.finerchem.com/pro01en/id/691.html Product Name Isoxepac CAS No. 55453-87-7
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:55453-87-7
Min.Order:1 Kilogram
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:55453-87-7
Min.Order:1 Metric Ton
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Type:Manufacturers
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:55453-87-7
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:Slightly yellow or off white powder Storage:Refrigerator Pack
Cas:55453-87-7
Min.Order:1 Kilogram
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inquiryhigh quality Appearance:White or off white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:55453-87-7
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:55453-87-7
Min.Order:1 Gram
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:55453-87-7
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:55453-87-7
Min.Order:1 Kilogram
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inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powder 2. Fact
Cas:55453-87-7
Min.Order:1 Kilogram
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:55453-87-7
Min.Order:1 Kilogram
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Cas:55453-87-7
Min.Order:10 Gram
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Type:Trading Company
inquiryIsoxepac CAS:55453-87-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s
Cas:55453-87-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Product Name: Isoxepac Synonyms: e)oxepin-2-aceticacid,6,11-dihydro-11-oxo-dibenz(;hp549;DIBENZ[B,E]OXEPIN-2-ACETIC ACID, 6,11-DIOHYDRO-11-OXO;6,11-Hydro-11-Oxo-Dibenz[B,E]Oxepin-2-Acetic Acid;Olapatadine;6,11-DIHYDRO-11-OXO-DIBENZ[B,E]OXEPIN-2-A
Cas:55453-87-7
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Cas:55453-87-7
Min.Order:0
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Type:Manufacturers
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:55453-87-7
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediates Tr
Product Name: Isoxepac Synonyms: Olopatadine Impurity 3(Olopatadine USP RC C);6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-acetic acid, 97.0%;e)oxepin-2-aceticacid,6,11-dihydro-11-oxo-dibenz(;hp549;DIBENZ[B,E]OXEPIN-2-ACETIC ACID, 6,11-DIOHYDRO-11-O
HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp
4-(2-carboxybenzyloxy) phenyl acetic acid
isoxepac
Conditions | Yield |
---|---|
Stage #1: 4-(2-carboxybenzyloxy) phenyl acetic acid With trifluoroacetic anhydride In chlorobenzene at 20℃; for 4h; Stage #2: boron trifluoride diethyl etherate In chlorobenzene at -10 - 0℃; for 0.666667h; | 96.4% |
Stage #1: 4-(2-carboxybenzyloxy) phenyl acetic acid With trifluorormethanesulfonic acid; trifluoroacetic anhydride In toluene at 20 - 35℃; for 1h; Stage #2: With water In toluene | 71.3% |
With acetic anhydride at 80 - 90℃; for 2h; Large scale; | 69.9% |
Conditions | Yield |
---|---|
Stage #1: 4-hydroxyphenylacetate With potassium hydroxide In methanol at 20℃; for 1h; Friedel-Crafts Acylation; Stage #2: 2-(chloromethyl)benzoic acid In methanol Reflux; Stage #3: With Eaton′s Reagent at 80℃; for 2h; Reagent/catalyst; Solvent; Concentration; | 79.3% |
methyl 2-bromomethylbenzoate
isoxepac
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: K2CO3, KI / butan-2-one / 24 h / Heating 2: KOH / aq. ethanol / Heating 3: 1.) (CF3CO)2O, 2.) 10percent aq. HCl / 1.) CH2Cl2, reflux, 4 h, 2.) acetone, reflux, 24 h View Scheme |
(4-hydroxy-phenyl)-acetic acid ethyl ester
isoxepac
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: K2CO3, KI / butan-2-one / 24 h / Heating 2: KOH / aq. ethanol / Heating 3: 1.) (CF3CO)2O, 2.) 10percent aq. HCl / 1.) CH2Cl2, reflux, 4 h, 2.) acetone, reflux, 24 h View Scheme |
isoxepac
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: KOH / aq. ethanol / Heating 2: 1.) (CF3CO)2O, 2.) 10percent aq. HCl / 1.) CH2Cl2, reflux, 4 h, 2.) acetone, reflux, 24 h View Scheme |
4-benzyloxy-3-carboxyphenylacetic acid
isoxepac
Conditions | Yield |
---|---|
In methylene chloride-nitromethane; 4-benzyloxy-3-chlorocarbonylphenylacetyl chloride |
4-hydroxyphenylacetate
isoxepac
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium methylate / N,N-dimethyl-formamide; methanol / 120 - 135 °C 1.2: 5 - 10 °C 2.1: acetic acid / 2.5 h / 70 - 75 °C View Scheme |
2-benzofuran-1(3H)-one
isoxepac
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium methylate / N,N-dimethyl-formamide; methanol / 120 - 135 °C 1.2: 5 - 10 °C 2.1: acetic acid / 2.5 h / 70 - 75 °C View Scheme |
4-(2-methoxycarbonylbenzyloxy)phenyl acetic acid
isoxepac
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / ethanol / 3 h / Reflux; Large scale 1.2: pH 1 - 2 / Large scale 2.1: acetic anhydride / 2 h / 80 - 90 °C / Large scale View Scheme |
o-(chloromethyl)benzoic acid methyl ester
isoxepac
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium carbonate / ethanol / 24 h / Reflux 2.1: potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / ethanol / 3 h / Reflux; Large scale 2.2: pH 1 - 2 / Large scale 3.1: acetic anhydride / 2 h / 80 - 90 °C / Large scale View Scheme |
Methyl 4-hydroxyphenylacetate
isoxepac
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium carbonate / ethanol / 24 h / Reflux 2.1: potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / ethanol / 3 h / Reflux; Large scale 2.2: pH 1 - 2 / Large scale 3.1: acetic anhydride / 2 h / 80 - 90 °C / Large scale View Scheme |
isoxepac
11-hydroxy-2-(2-hydroxyethyl)-6,11-dihydrodibenz[b,e]oxepin
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran for 1h; Ambient temperature; | 98% |
isoxepac
benzyl alcohol
(11-oxo-6,11-dihydro-dibenzo[b,e]oxepin-2-yl)-acetic acid benzyl ester
Conditions | Yield |
---|---|
toluene-4-sulfonic acid In toluene Reflux; | 98% |
isoxepac
tert-butyl alcohol
Conditions | Yield |
---|---|
With 1-methyl-1H-imidazole; di-tert-butyl dicarbonate; triethylamine In toluene at 50℃; for 8.5h; Reagent/catalyst; Solvent; Temperature; | 97% |
Stage #1: isoxepac With trifluoroacetic anhydride In toluene at 20℃; for 1h; Stage #2: tert-butyl alcohol In toluene at 20 - 80℃; for 4h; | 79.9% |
isoxepac
(Z)-11-(3-dimethylaminopropylidene)-6,11-dihydro-dibenz-[b,e]oxepine-2-acetic acid hydrobromide
Conditions | Yield |
---|---|
Stage #1: anhydrous 3-(dimethylamino)propyltriphenylphosphonium bromide hydrobromide With sodium hydride In tetrahydrofuran at 20 - 60℃; for 3.66667h; Stage #2: isoxepac In tetrahydrofuran at 10 - 25℃; for 20 - 30h; Wittig Reaction; Stage #3: With hydrogen bromide In 2-methyltetrahydrofuran; water; isopropyl alcohol pH=4.3 - 13.8; Product distribution / selectivity; | 96.95% |
Stage #1: (3-dimethylaminopropyl)-triphenylphosphoniumbromide With sodium hydride In tetrahydrofuran at 20 - 60℃; for 2.5h; Stage #2: isoxepac In tetrahydrofuran at 15 - 25℃; for 40h; Wittig Reaction; Stage #3: With hydrogen bromide In water; butan-1-ol at 0 - 25℃; pH=4.2 - 12.59; Product distribution / selectivity; | 53.5% |
isoxepac
isopropyl alcohol
(11-oxo-6,11-dihydro-dibenzo[b,e]oxepin-2-yl)-acetic acid isopropyl ester
Conditions | Yield |
---|---|
toluene-4-sulfonic acid Reflux; | 96% |
methanol
isoxepac
methyl 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetate
Conditions | Yield |
---|---|
With tert.-butylnitrite at 40℃; for 48h; | 96% |
With thionyl chloride at 0 - 20℃; for 24.5h; | |
With thionyl chloride at 0 - 25℃; for 24.5h; |
isoxepac
ethanol
ethyl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid for 2h; Reflux; | 94% |
toluene-4-sulfonic acid Reflux; | 93% |
isoxepac
butan-1-ol
(11-oxo-6,11-dihydro-dibenzo[b,e]oxepin-2-yl)-acetic acid butyl ester
Conditions | Yield |
---|---|
With sulfuric acid at 115℃; | 93% |
With sulfuric acid at 115℃; for 2h; Dean Stark apparatus; | 93% |
isoxepac
olopatadine hydrochloride
Conditions | Yield |
---|---|
Stage #1: N-(3-chloropropyl)-N,N-dimethylamine hydrochloride With potassium bromide for 1h; Inert atmosphere; Stage #2: With N,N,N,N,N,N-hexamethylphosphoric triamide In dimethyl sulfoxide for 2h; Reflux; Stage #3: isoxepac In dimethyl sulfoxide at 20℃; for 1h; Reagent/catalyst; Solvent; | 90.5% |
isoxepac
Cyclopropylamine
Conditions | Yield |
---|---|
Stage #1: isoxepac With 1,1'-carbonyldiimidazole In dichloromethane for 1h; Stage #2: Cyclopropylamine In dichloromethane at 20℃; for 2h; | 90% |
Stage #1: isoxepac With 1,1'-carbonyldiimidazole In dichloromethane for 1h; Stage #2: Cyclopropylamine In dichloromethane at 20℃; for 2h; | 90% |
isoxepac
1-bromo-3-propanol
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 24h; Inert atmosphere; | 89% |
isoxepac
6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-carboxaldehyde
Conditions | Yield |
---|---|
With tris(bipyridine)ruthenium(II) dichloride hexahydrate; 1-λ3-benzo[d][1,2]iodaoxol-3(1H)-one In 2,2,2-trifluoroethanol at 40℃; for 3h; UV-irradiation; | 86% |
With oxygen; copper diacetate In dimethyl sulfoxide at 120℃; |
Conditions | Yield |
---|---|
Stage #1: isoxepac With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; for 2h; Inert atmosphere; Stage #2: monomethyl monopotassium malonate With magnesium chloride In dichloromethane at 20℃; for 24h; Inert atmosphere; | 86% |
Conditions | Yield |
---|---|
Stage #1: isoxepac With potassium carbonate; trichlorophosphate In water; chlorobenzene at 40℃; Stage #2: isobutene In water; chlorobenzene at 40℃; for 8h; Product distribution / selectivity; | 85.3% |
isoxepac
hex-5-en-3-yn-1-ol
Conditions | Yield |
---|---|
With dmap; diisopropyl-carbodiimide In dichloromethane at 20℃; for 12h; Inert atmosphere; Schlenk technique; | 84% |
isoxepac
2-(chloromethyl)dibenzo[b,e]oxepin-11(6H)-one
Conditions | Yield |
---|---|
With tris(bipyridine)ruthenium(II) dichloride hexahydrate; dibenzenesulfonamide; 1-λ3-benzo[d][1,2]iodaoxol-3(1H)-one; tetrabutyl-ammonium chloride In dichloromethane at 40℃; for 24h; Inert atmosphere; Schlenk technique; Irradiation; | 82% |
isoxepac
(4-vinyl-phenyl)-methanol
Conditions | Yield |
---|---|
With dmap; diisopropyl-carbodiimide In dichloromethane | 82% |
Conditions | Yield |
---|---|
Stage #1: N,N-dimethyl-3-bromopropylamine With zinc dibromide In tetrahydrofuran at 10 - 20℃; for 0.166667h; Inert atmosphere; Stage #2: With naphthalene; lithium In tetrahydrofuran at 65 - 70℃; Inert atmosphere; Stage #3: isoxepac In tetrahydrofuran at 0 - 25℃; for 16.5h; Reagent/catalyst; Temperature; | 81.2% |
isoxepac
2,2,2-trifluoroethanol
Conditions | Yield |
---|---|
With thionyl chloride; triethylamine at 0 - 40℃; for 12.3333h; Inert atmosphere; | 80% |
N-hydroxyphthalimide
isoxepac
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; | 80% |
With dmap; diisopropyl-carbodiimide In dichloromethane at 20℃; for 1h; | 71% |
With dmap; diisopropyl-carbodiimide In dichloromethane |
isoxepac
Conditions | Yield |
---|---|
With dmap; copper diacetate In acetonitrile at 80℃; for 3h; Schlenk technique; Sealed tube; | 80% |
3-(N,N-dimethylamino)propylmagnesium chloride
isoxepac
Conditions | Yield |
---|---|
Stage #1: 3-(N,N-dimethylamino)propylmagnesium chloride; isoxepac In tetrahydrofuran; toluene at 5 - 18℃; for 2.08333h; Stage #2: With water; acetic acid In tetrahydrofuran; toluene | 79.7% |
isoxepac
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃; for 12.5h; Inert atmosphere; | 79% |
isoxepac
methylamine hydrochloride
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane | 78% |
isoxepac
dibenzenesulfonamide
Conditions | Yield |
---|---|
With tris(bipyridine)ruthenium(II) dichloride hexahydrate; 1-λ3-benzo[d][1,2]iodaoxol-3(1H)-one In dichloromethane at 40℃; for 24h; Inert atmosphere; Schlenk technique; Irradiation; | 75% |
isoxepac
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 24h; | 72% |
Conditions | Yield |
---|---|
With 1,1'-carbonyldiimidazole In dichloromethane at 0 - 20℃; for 2h; | 72% |
isoxepac
6,11-dihydro-11-oxodibenz[b,e]oxepin-2-carboxylic acid
Conditions | Yield |
---|---|
With tris(bipyridine)ruthenium(II) dichloride hexahydrate; [bis(acetoxy)iodo]benzene; oxygen In 2,2,2-trifluoroethanol for 24h; UV-irradiation; | 70% |
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