Product Name

  • Name

    Isoxepac

  • EINECS 611-268-9
  • CAS No. 55453-87-7
  • Article Data15
  • CAS DataBase
  • Density 1.349 g/cm3
  • Solubility
  • Melting Point 130-132oC
  • Formula C16H12O4
  • Boiling Point 528.2 °C at 760 mmHg
  • Molecular Weight 268.269
  • Flash Point 203.8 °C
  • Transport Information
  • Appearance Light-yellow to pale-white crystalline powder
  • Safety 36/37-45
  • Risk Codes 25-62
  • Molecular Structure Molecular Structure of 55453-87-7 (Isoxepac)
  • Hazard Symbols T
  • Synonyms 11-Oxo-6,11-dihydrodibenz[b,e]oxepin-2-aceticacid;6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid;Artil;HP 549;NSC 300907;P 720549;
  • PSA 63.60000
  • LogP 2.43710

Synthetic route

4-(2-carboxybenzyloxy) phenyl acetic acid
55453-89-9

4-(2-carboxybenzyloxy) phenyl acetic acid

isoxepac
55453-87-7

isoxepac

Conditions
ConditionsYield
Stage #1: 4-(2-carboxybenzyloxy) phenyl acetic acid With trifluoroacetic anhydride In chlorobenzene at 20℃; for 4h;
Stage #2: boron trifluoride diethyl etherate In chlorobenzene at -10 - 0℃; for 0.666667h;		96.4%
Stage #1: 4-(2-carboxybenzyloxy) phenyl acetic acid With trifluorormethanesulfonic acid; trifluoroacetic anhydride In toluene at 20 - 35℃; for 1h;
Stage #2: With water In toluene		71.3%
With acetic anhydride at 80 - 90℃; for 2h; Large scale;69.9%
4-hydroxyphenylacetate
156-38-7

4-hydroxyphenylacetate

2-(chloromethyl)benzoic acid
85888-81-9

2-(chloromethyl)benzoic acid

isoxepac
55453-87-7

isoxepac

Conditions
ConditionsYield
Stage #1: 4-hydroxyphenylacetate With potassium hydroxide In methanol at 20℃; for 1h; Friedel-Crafts Acylation;
Stage #2: 2-(chloromethyl)benzoic acid In methanol Reflux;
Stage #3: With Eaton′s Reagent at 80℃; for 2h; Reagent/catalyst; Solvent; Concentration;		79.3%
methyl 2-bromomethylbenzoate
2417-73-4

methyl 2-bromomethylbenzoate

isoxepac
55453-87-7

isoxepac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: K2CO3, KI / butan-2-one / 24 h / Heating
2: KOH / aq. ethanol / Heating
3: 1.) (CF3CO)2O, 2.) 10percent aq. HCl / 1.) CH2Cl2, reflux, 4 h, 2.) acetone, reflux, 24 h
View Scheme
(4-hydroxy-phenyl)-acetic acid ethyl ester
17138-28-2

(4-hydroxy-phenyl)-acetic acid ethyl ester

isoxepac
55453-87-7

isoxepac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: K2CO3, KI / butan-2-one / 24 h / Heating
2: KOH / aq. ethanol / Heating
3: 1.) (CF3CO)2O, 2.) 10percent aq. HCl / 1.) CH2Cl2, reflux, 4 h, 2.) acetone, reflux, 24 h
View Scheme
2-(4-Ethoxycarbonylmethyl-phenoxymethyl)-benzoic acid methyl ester

2-(4-Ethoxycarbonylmethyl-phenoxymethyl)-benzoic acid methyl ester

isoxepac
55453-87-7

isoxepac

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: KOH / aq. ethanol / Heating
2: 1.) (CF3CO)2O, 2.) 10percent aq. HCl / 1.) CH2Cl2, reflux, 4 h, 2.) acetone, reflux, 24 h
View Scheme
4-benzyloxy-3-carboxyphenylacetic acid
69031-39-6

4-benzyloxy-3-carboxyphenylacetic acid

isoxepac
55453-87-7

isoxepac

Conditions
ConditionsYield
In methylene chloride-nitromethane; 4-benzyloxy-3-chlorocarbonylphenylacetyl chloride
4-hydroxyphenylacetate
156-38-7

4-hydroxyphenylacetate

isoxepac
55453-87-7

isoxepac

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium methylate / N,N-dimethyl-formamide; methanol / 120 - 135 °C
1.2: 5 - 10 °C
2.1: acetic acid / 2.5 h / 70 - 75 °C
View Scheme
2-benzofuran-1(3H)-one
87-41-2

2-benzofuran-1(3H)-one

isoxepac
55453-87-7

isoxepac

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium methylate / N,N-dimethyl-formamide; methanol / 120 - 135 °C
1.2: 5 - 10 °C
2.1: acetic acid / 2.5 h / 70 - 75 °C
View Scheme
4-(2-methoxycarbonylbenzyloxy)phenyl acetic acid
1009378-92-0

4-(2-methoxycarbonylbenzyloxy)phenyl acetic acid

isoxepac
55453-87-7

isoxepac

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / ethanol / 3 h / Reflux; Large scale
1.2: pH 1 - 2 / Large scale
2.1: acetic anhydride / 2 h / 80 - 90 °C / Large scale
View Scheme
o-(chloromethyl)benzoic acid methyl ester
34040-62-5

o-(chloromethyl)benzoic acid methyl ester

isoxepac
55453-87-7

isoxepac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / ethanol / 24 h / Reflux
2.1: potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / ethanol / 3 h / Reflux; Large scale
2.2: pH 1 - 2 / Large scale
3.1: acetic anhydride / 2 h / 80 - 90 °C / Large scale
View Scheme
Methyl 4-hydroxyphenylacetate
14199-15-6

Methyl 4-hydroxyphenylacetate

isoxepac
55453-87-7

isoxepac

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / ethanol / 24 h / Reflux
2.1: potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / ethanol / 3 h / Reflux; Large scale
2.2: pH 1 - 2 / Large scale
3.1: acetic anhydride / 2 h / 80 - 90 °C / Large scale
View Scheme
isoxepac
55453-87-7

isoxepac

11-hydroxy-2-(2-hydroxyethyl)-6,11-dihydrodibenz[b,e]oxepin
56427-65-7

11-hydroxy-2-(2-hydroxyethyl)-6,11-dihydrodibenz[b,e]oxepin

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran for 1h; Ambient temperature;98%
isoxepac
55453-87-7

isoxepac

benzyl alcohol
100-51-6

benzyl alcohol

(11-oxo-6,11-dihydro-dibenzo[b,e]oxepin-2-yl)-acetic acid benzyl ester
60548-16-5

(11-oxo-6,11-dihydro-dibenzo[b,e]oxepin-2-yl)-acetic acid benzyl ester

Conditions
ConditionsYield
toluene-4-sulfonic acid In toluene Reflux;98%
isoxepac
55453-87-7

isoxepac

tert-butyl alcohol
75-65-0

tert-butyl alcohol

tert-butyl 11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-acetate

tert-butyl 11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-acetate

Conditions
ConditionsYield
With 1-methyl-1H-imidazole; di-tert-butyl dicarbonate; triethylamine In toluene at 50℃; for 8.5h; Reagent/catalyst; Solvent; Temperature;97%
Stage #1: isoxepac With trifluoroacetic anhydride In toluene at 20℃; for 1h;
Stage #2: tert-butyl alcohol In toluene at 20 - 80℃; for 4h;		79.9%
isoxepac
55453-87-7

isoxepac

(Z)-11-(3-dimethylaminopropylidene)-6,11-dihydro-dibenz-[b,e]oxepine-2-acetic acid hydrobromide
951006-73-8

(Z)-11-(3-dimethylaminopropylidene)-6,11-dihydro-dibenz-[b,e]oxepine-2-acetic acid hydrobromide

Conditions
ConditionsYield
Stage #1: anhydrous 3-(dimethylamino)propyltriphenylphosphonium bromide hydrobromide With sodium hydride In tetrahydrofuran at 20 - 60℃; for 3.66667h;
Stage #2: isoxepac In tetrahydrofuran at 10 - 25℃; for 20 - 30h; Wittig Reaction;
Stage #3: With hydrogen bromide In 2-methyltetrahydrofuran; water; isopropyl alcohol pH=4.3 - 13.8; Product distribution / selectivity;		96.95%
Stage #1: (3-dimethylaminopropyl)-triphenylphosphoniumbromide With sodium hydride In tetrahydrofuran at 20 - 60℃; for 2.5h;
Stage #2: isoxepac In tetrahydrofuran at 15 - 25℃; for 40h; Wittig Reaction;
Stage #3: With hydrogen bromide In water; butan-1-ol at 0 - 25℃; pH=4.2 - 12.59; Product distribution / selectivity;		53.5%
isoxepac
55453-87-7

isoxepac

isopropyl alcohol
67-63-0

isopropyl alcohol

(11-oxo-6,11-dihydro-dibenzo[b,e]oxepin-2-yl)-acetic acid isopropyl ester
56427-76-0

(11-oxo-6,11-dihydro-dibenzo[b,e]oxepin-2-yl)-acetic acid isopropyl ester

Conditions
ConditionsYield
toluene-4-sulfonic acid Reflux;96%
methanol
67-56-1

methanol

isoxepac
55453-87-7

isoxepac

methyl 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetate
55689-64-0

methyl 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetate

Conditions
ConditionsYield
With tert.-butylnitrite at 40℃; for 48h;96%
With thionyl chloride at 0 - 20℃; for 24.5h;
With thionyl chloride at 0 - 25℃; for 24.5h;
isoxepac
55453-87-7

isoxepac

ethanol
64-17-5

ethanol

ethyl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate
55453-90-2

ethyl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

Conditions
ConditionsYield
With toluene-4-sulfonic acid for 2h; Reflux;94%
toluene-4-sulfonic acid Reflux;93%
isoxepac
55453-87-7

isoxepac

butan-1-ol
71-36-3

butan-1-ol

(11-oxo-6,11-dihydro-dibenzo[b,e]oxepin-2-yl)-acetic acid butyl ester
60548-14-3

(11-oxo-6,11-dihydro-dibenzo[b,e]oxepin-2-yl)-acetic acid butyl ester

Conditions
ConditionsYield
With sulfuric acid at 115℃;93%
With sulfuric acid at 115℃; for 2h; Dean Stark apparatus;93%
isoxepac
55453-87-7

isoxepac

N-(3-chloropropyl)-N,N-dimethylamine hydrochloride

N-(3-chloropropyl)-N,N-dimethylamine hydrochloride

olopatadine hydrochloride
140462-76-6

olopatadine hydrochloride

Conditions
ConditionsYield
Stage #1: N-(3-chloropropyl)-N,N-dimethylamine hydrochloride With potassium bromide for 1h; Inert atmosphere;
Stage #2: With N,N,N,N,N,N-hexamethylphosphoric triamide In dimethyl sulfoxide for 2h; Reflux;
Stage #3: isoxepac In dimethyl sulfoxide at 20℃; for 1h; Reagent/catalyst; Solvent;		90.5%
isoxepac
55453-87-7

isoxepac

Cyclopropylamine
765-30-0

Cyclopropylamine

N-cyclopropyl-2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetamide

N-cyclopropyl-2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetamide

Conditions
ConditionsYield
Stage #1: isoxepac With 1,1'-carbonyldiimidazole In dichloromethane for 1h;
Stage #2: Cyclopropylamine In dichloromethane at 20℃; for 2h;		90%
Stage #1: isoxepac With 1,1'-carbonyldiimidazole In dichloromethane for 1h;
Stage #2: Cyclopropylamine In dichloromethane at 20℃; for 2h;		90%
isoxepac
55453-87-7

isoxepac

1-bromo-3-propanol
627-18-9

1-bromo-3-propanol

3-bromopropyl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

3-bromopropyl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 24h; Inert atmosphere;89%
isoxepac
55453-87-7

isoxepac

6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-carboxaldehyde
66801-46-5

6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-carboxaldehyde

Conditions
ConditionsYield
With tris(bipyridine)ruthenium(II) dichloride hexahydrate; 1-λ3-benzo[d][1,2]iodaoxol-3(1H)-one In 2,2,2-trifluoroethanol at 40℃; for 3h; UV-irradiation;86%
With oxygen; copper diacetate In dimethyl sulfoxide at 120℃;
isoxepac
55453-87-7

isoxepac

monomethyl monopotassium malonate
38330-80-2

monomethyl monopotassium malonate

C19H16O5

C19H16O5

Conditions
ConditionsYield
Stage #1: isoxepac With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;
Stage #2: monomethyl monopotassium malonate With magnesium chloride In dichloromethane at 20℃; for 24h; Inert atmosphere;		86%
isoxepac
55453-87-7

isoxepac

isobutene
115-11-7

isobutene

tert-butyl 11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-acetate

tert-butyl 11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-acetate

Conditions
ConditionsYield
Stage #1: isoxepac With potassium carbonate; trichlorophosphate In water; chlorobenzene at 40℃;
Stage #2: isobutene In water; chlorobenzene at 40℃; for 8h; Product distribution / selectivity;		85.3%
isoxepac
55453-87-7

isoxepac

hex-5-en-3-yn-1-ol
28916-38-3

hex-5-en-3-yn-1-ol

hex-5-en-3-yn-1-yl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

hex-5-en-3-yn-1-yl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

Conditions
ConditionsYield
With dmap; diisopropyl-carbodiimide In dichloromethane at 20℃; for 12h; Inert atmosphere; Schlenk technique;84%
isoxepac
55453-87-7

isoxepac

2-(chloromethyl)dibenzo[b,e]oxepin-11(6H)-one
66801-38-5

2-(chloromethyl)dibenzo[b,e]oxepin-11(6H)-one

Conditions
ConditionsYield
With tris(bipyridine)ruthenium(II) dichloride hexahydrate; dibenzenesulfonamide; 1-λ3-benzo[d][1,2]iodaoxol-3(1H)-one; tetrabutyl-ammonium chloride In dichloromethane at 40℃; for 24h; Inert atmosphere; Schlenk technique; Irradiation;82%
isoxepac
55453-87-7

isoxepac

(4-vinyl-phenyl)-methanol
1074-61-9

(4-vinyl-phenyl)-methanol

4-vinylbenzyl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

4-vinylbenzyl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

Conditions
ConditionsYield
With dmap; diisopropyl-carbodiimide In dichloromethane82%
isoxepac
55453-87-7

isoxepac

N,N-dimethyl-3-bromopropylamine
53929-74-1

N,N-dimethyl-3-bromopropylamine

olopatadine
113806-05-6

olopatadine

Conditions
ConditionsYield
Stage #1: N,N-dimethyl-3-bromopropylamine With zinc dibromide In tetrahydrofuran at 10 - 20℃; for 0.166667h; Inert atmosphere;
Stage #2: With naphthalene; lithium In tetrahydrofuran at 65 - 70℃; Inert atmosphere;
Stage #3: isoxepac In tetrahydrofuran at 0 - 25℃; for 16.5h; Reagent/catalyst; Temperature;		81.2%
isoxepac
55453-87-7

isoxepac

2,2,2-trifluoroethanol
75-89-8

2,2,2-trifluoroethanol

2,2,2-trifluoroethyl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

2,2,2-trifluoroethyl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

Conditions
ConditionsYield
With thionyl chloride; triethylamine at 0 - 40℃; for 12.3333h; Inert atmosphere;80%
N-hydroxyphthalimide
524-38-9

N-hydroxyphthalimide

isoxepac
55453-87-7

isoxepac

1,3-dioxoisoindolin-2-yl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

1,3-dioxoisoindolin-2-yl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;80%
With dmap; diisopropyl-carbodiimide In dichloromethane at 20℃; for 1h;71%
With dmap; diisopropyl-carbodiimide In dichloromethane
isoxepac
55453-87-7

isoxepac

2,2,2,-trichloroethoxycarbonyl azide

2,2,2,-trichloroethoxycarbonyl azide

2,2,2-trichloroethyl ((11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)methyl)carbamate

2,2,2-trichloroethyl ((11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)methyl)carbamate

Conditions
ConditionsYield
With dmap; copper diacetate In acetonitrile at 80℃; for 3h; Schlenk technique; Sealed tube;80%
3-(N,N-dimethylamino)propylmagnesium chloride
19070-16-7

3-(N,N-dimethylamino)propylmagnesium chloride

isoxepac
55453-87-7

isoxepac

11-hydroxy-11-(3-dimethylaminopropyl)-6,11-dihydrodibenz[b,e] oxepin-2-acetic acid

11-hydroxy-11-(3-dimethylaminopropyl)-6,11-dihydrodibenz[b,e] oxepin-2-acetic acid

Conditions
ConditionsYield
Stage #1: 3-(N,N-dimethylamino)propylmagnesium chloride; isoxepac In tetrahydrofuran; toluene at 5 - 18℃; for 2.08333h;
Stage #2: With water; acetic acid In tetrahydrofuran; toluene		79.7%
isoxepac
55453-87-7

isoxepac

4-bromo-5, 5, 5-trifluoropentan-1-ol

4-bromo-5, 5, 5-trifluoropentan-1-ol

4-bromo-5,5,5-trifluoropentyl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

4-bromo-5,5,5-trifluoropentyl 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃; for 12.5h; Inert atmosphere;79%
isoxepac
55453-87-7

isoxepac

methylamine hydrochloride
593-51-1

methylamine hydrochloride

N-methyl-2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetamide

N-methyl-2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetamide

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane78%
isoxepac
55453-87-7

isoxepac

dibenzenesulfonamide
2618-96-4

dibenzenesulfonamide

N-[(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)methyl]-N-phenylsulfonylbenzenesulfonamide

N-[(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)methyl]-N-phenylsulfonylbenzenesulfonamide

Conditions
ConditionsYield
With tris(bipyridine)ruthenium(II) dichloride hexahydrate; 1-λ3-benzo[d][1,2]iodaoxol-3(1H)-one In dichloromethane at 40℃; for 24h; Inert atmosphere; Schlenk technique; Irradiation;75%
isoxepac
55453-87-7

isoxepac

1-(1-hydroxybutan-2-yl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate

1-(1-hydroxybutan-2-yl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate

1-(1-(2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetoxy)butan-2-yl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate

1-(1-(2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetoxy)butan-2-yl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 24h;72%
isoxepac
55453-87-7

isoxepac

Propargylamine
2450-71-7

Propargylamine

C19H15NO3

C19H15NO3

Conditions
ConditionsYield
With 1,1'-carbonyldiimidazole In dichloromethane at 0 - 20℃; for 2h;72%
isoxepac
55453-87-7

isoxepac

6,11-dihydro-11-oxodibenz[b,e]oxepin-2-carboxylic acid
66801-40-9

6,11-dihydro-11-oxodibenz[b,e]oxepin-2-carboxylic acid

Conditions
ConditionsYield
With tris(bipyridine)ruthenium(II) dichloride hexahydrate; [bis(acetoxy)iodo]benzene; oxygen In 2,2,2-trifluoroethanol for 24h; UV-irradiation;70%

Isoxepac Chemical Properties

Molecular structure of Isoxepac (CAS NO.55453-87-7) is:

Product Name: Isoxepac
CAS Registry Number: 55453-87-7
IUPAC Name: 2-(11-oxo-6H-benzo[c][2]benzoxepin-2-yl)acetic acid
Molecular Weight: 268.26408 [g/mol]
Molecular Formula: C16H12O4
XLogP3: 2.4
H-Bond Donor: 1
H-Bond Acceptor: 4 
Surface Tension: 58.8 dyne/cm
Density: 1.349 g/cm3
Flash Point: 203.8 °C
Enthalpy of Vaporization: 84.52 kJ/mol
Boiling Point: 528.2 °C at 760 mmHg
Vapour Pressure: 5.51E-12 mmHg at 25°C
Product Categories: APIs Intermediate

Isoxepac Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 240mg/kg (240mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 227, Pg. 142, 1977.
mouse LD50 oral 500mg/kg (500mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 227, Pg. 142, 1977.
rabbit LD50 oral 160mg/kg (160mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 227, Pg. 142, 1977.
rat LD50 oral 143mg/kg (143mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 227, Pg.

Isoxepac Specification

 Isoxepac , its cas register number is 55453-87-7. It also can be called 6,11-Dihydro-11-oxodibenz(b,e)oxepin-2-acetic acid ; Arelix ; Artil ; Dibenz(b,e)oxepin-2-acetic acid, 6,11-dihydro-11-oxo- ; Isoxepacum [INN-Latin] .It is a light-yellow to pale-white crystalline powder.

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