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inquiryUnique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:pharmaceutical intermediate Transpo
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inquiry7-MAC English name: 7-MAC Chemical name: (7S)-benzhydryl 7-amino-7-methoxy-3-((1-methyl-1H-tetrazol-5-ylthio)methyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Category involve
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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Products: 7-MAC; Methoxycephalosporin Name: 7beta-amino-7alpha-methoxy-3-(1-methyl-1H-tetrazole-5-thiomethyl) -8-oxo-5-sulfo-1-aza bicyclic [4.2.0] octyl-2-ene-2-formic acid diphenylmethyl ester English Name: 7beta-amino-7alpha-methoxy-3
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
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inquiryWuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides
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inquiryAbout Product Details Items Specifications Test Results Appearance White to white crystalline powde
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
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J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryHuarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.
Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of service
High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
Conditions | Yield |
---|---|
With pyridine; bis(trichloromethyl) carbonate In dichloromethane at -25 - 5℃; for 3h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere; | 94.1% |
(6R-cis)-7-methoxy-3-<<(1-methyl-1-H-tetrazol-5-yl)thio>methyl>-8-oxo<(phenylacetyl)amino>-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
Conditions | Yield |
---|---|
With pyridine; phosphorus pentachloride In methanol; dichloromethane at -30 - 5℃; for 4h; Reagent/catalyst; | 91% |
Stage #1: (6R-cis)-7-methoxy-3-<<(1-methyl-1-H-tetrazol-5-yl)thio>methyl>-8-oxo<(phenylacetyl)amino>-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester With pyridine; phosphorus pentachloride In dichloromethane at 5 - 8℃; for 2h; Stage #2: In methanol at -30 - -10℃; for 2h; | 90% |
2-amino-benzenethiol
(6R,7S)-7-[1-Chloro-but-(E)-ylideneamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
A
2-propylbenzo[d]thiazole
B
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
C
(6R,7S)-7-Butyrylamino-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
With pyridine In dichloromethane for 1.5h; Ambient temperature; | A 45% B 15% C 23% |
(6R,7S)-7-[1-Chloro-but-(E)-ylideneamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
A
2-propylbenzo[d]thiazole
B
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
C
(6R,7S)-7-Butyrylamino-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
With pyridine; 2-amino-benzenethiol In dichloromethane for 1.5h; Ambient temperature; | A 45% B 15% C 23% |
2-amino-benzenethiol
A
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
Conditions | Yield |
---|---|
With pyridine In dichloromethane Ambient temperature; | A 25% B 35% |
A
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
Conditions | Yield |
---|---|
With pyridine; 2-amino-benzenethiol In dichloromethane Ambient temperature; | A 25% B 35% |
(6R)-7t-(3,5-di-tert-butyl-4-hydroxy-benzylideneamino)-7c-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
Conditions | Yield |
---|---|
With girard's reagent T In methanol; ethyl acetate Ambient temperature; |
(6R,7S)-7-(5-Benzhydryloxycarbonyl-5-tert-butoxycarbonylamino-pentanoylamino)-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: phosgene-pyridine / CH2Cl2 / Ambient temperature 2: 25 percent / pyridine / CH2Cl2 / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: phosgene-pyridine / CH2Cl2 / Ambient temperature 2: 25 percent / pyridine, o-amino-benzenethiol / CH2Cl2 / Ambient temperature View Scheme |
(6R,7S)-7-Butyrylamino-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: phosgene-pyridine / CH2Cl2 / 3 h / Ambient temperature 2: 15 percent / pyridine, o-amino-benzenethiol / CH2Cl2 / 1.5 h / Ambient temperature View Scheme |
7β-amino-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>ceph-3-em-4-oic acid benzhydryl ester
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: (i) benzene, (ii) PbO2, 1,2-dichloroethane, (iii) /BRN= 1098229/, benzene 2: Girard T / ethyl acetate; methanol / Ambient temperature View Scheme |
7-Aminocephalosporanic acid
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: boron trifluoride diethyl etherate / acetonitrile / 2.5 h / 50 °C 2.1: sodium hydrogencarbonate / water; acetone / 3.67 h / 0 - 20 °C 3.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / -20 °C 4.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 6 h / 0 °C 5.1: phosphorus trichloride / dichloromethane / 3 h / Reflux 6.1: tert-butylhypochlorite / tetrahydrofuran; methanol / 0.37 h / -78 °C / Inert atmosphere 7.1: pyridine; phosphorus pentachloride / dichloromethane / 2 h / 5 - 8 °C 7.2: 2 h / -30 - -10 °C View Scheme | |
Multi-step reaction with 7 steps 1: boron trifluoride diethyl etherate / acetonitrile / 2.5 h / 50 °C 2: sodium hydrogencarbonate / acetone; water / 3 h / 0 - 25 °C 3: dicyclohexyl-carbodiimide; dmap / dichloromethane / -20 °C 4: 3-chloro-benzenecarboperoxoic acid / chloroform / 6 h / 0 - 5 °C 5: phosphorus trichloride / dichloromethane / 3 h / Reflux 6: tert-butylhypochlorite; lithium methanolate / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere 7: pyridine; phosphorus pentachloride / dichloromethane; methanol / 4 h / -30 - 5 °C View Scheme |
(6R,7R)-7-amino-3-[(1H-1-methyltetrazol-5-yl)thio]methylceph-3-em-4-carboxylic acid
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: sodium hydrogencarbonate / water; acetone / 3.67 h / 0 - 20 °C 2.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / -20 °C 3.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 6 h / 0 °C 4.1: phosphorus trichloride / dichloromethane / 3 h / Reflux 5.1: tert-butylhypochlorite / tetrahydrofuran; methanol / 0.37 h / -78 °C / Inert atmosphere 6.1: pyridine; phosphorus pentachloride / dichloromethane / 2 h / 5 - 8 °C 6.2: 2 h / -30 - -10 °C View Scheme | |
Multi-step reaction with 6 steps 1: sodium hydrogencarbonate / acetone; water / 3 h / 0 - 25 °C 2: dicyclohexyl-carbodiimide; dmap / dichloromethane / -20 °C 3: 3-chloro-benzenecarboperoxoic acid / chloroform / 6 h / 0 - 5 °C 4: phosphorus trichloride / dichloromethane / 3 h / Reflux 5: tert-butylhypochlorite; lithium methanolate / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere 6: pyridine; phosphorus pentachloride / dichloromethane; methanol / 4 h / -30 - 5 °C View Scheme |
(6R,7R)-3-((1-methyl-1H-tetrazol-5-ylthio)methyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-aza-bicyclo [4.2.0]oct-2-ene-2-carboxylic acid
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / -20 °C 2.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 6 h / 0 °C 3.1: phosphorus trichloride / dichloromethane / 3 h / Reflux 4.1: tert-butylhypochlorite / tetrahydrofuran; methanol / 0.37 h / -78 °C / Inert atmosphere 5.1: pyridine; phosphorus pentachloride / dichloromethane / 2 h / 5 - 8 °C 5.2: 2 h / -30 - -10 °C View Scheme | |
Multi-step reaction with 5 steps 1: dicyclohexyl-carbodiimide; dmap / dichloromethane / -20 °C 2: 3-chloro-benzenecarboperoxoic acid / chloroform / 6 h / 0 - 5 °C 3: phosphorus trichloride / dichloromethane / 3 h / Reflux 4: tert-butylhypochlorite; lithium methanolate / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere 5: pyridine; phosphorus pentachloride / dichloromethane; methanol / 4 h / -30 - 5 °C View Scheme |
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 6 h / 0 °C 2.1: phosphorus trichloride / dichloromethane / 3 h / Reflux 3.1: tert-butylhypochlorite / tetrahydrofuran; methanol / 0.37 h / -78 °C / Inert atmosphere 4.1: pyridine; phosphorus pentachloride / dichloromethane / 2 h / 5 - 8 °C 4.2: 2 h / -30 - -10 °C View Scheme | |
Multi-step reaction with 4 steps 1: 3-chloro-benzenecarboperoxoic acid / chloroform / 6 h / 0 - 5 °C 2: phosphorus trichloride / dichloromethane / 3 h / Reflux 3: tert-butylhypochlorite; lithium methanolate / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere 4: pyridine; phosphorus pentachloride / dichloromethane; methanol / 4 h / -30 - 5 °C View Scheme |
C31H28N6O5S2
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: phosphorus trichloride / dichloromethane / 3 h / Reflux 2.1: tert-butylhypochlorite / tetrahydrofuran; methanol / 0.37 h / -78 °C / Inert atmosphere 3.1: pyridine; phosphorus pentachloride / dichloromethane / 2 h / 5 - 8 °C 3.2: 2 h / -30 - -10 °C View Scheme | |
Multi-step reaction with 3 steps 1: phosphorus trichloride / dichloromethane / 3 h / Reflux 2: tert-butylhypochlorite; lithium methanolate / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere 3: pyridine; phosphorus pentachloride / dichloromethane; methanol / 4 h / -30 - 5 °C View Scheme |
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
Glyoxilic acid
Conditions | Yield |
---|---|
Stage #1: Glyoxilic acid With 1,1'-carbonyldiimidazole In dichloromethane Stage #2: diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate In dichloromethane at 40℃; for 10h; Reagent/catalyst; | 98.8% |
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
Conditions | Yield |
---|---|
With 1,1'-carbonyldiimidazole In ethyl acetate at 40℃; for 10h; | 98.6% |
chlorocarbonyl-[4-(4-methoxy-benzyloxy)-phenyl]-acetic acid 4-methoxy-benzyl ester
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
(6R,7S)-7-Methoxy-7-{2-(4-methoxy-benzyloxycarbonyl)-2-[4-(4-methoxy-benzyloxy)-phenyl]-acetylamino}-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
With pyridine | 75% |
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at -10℃; | 51.5% |
gloutaric dichloride
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
Conditions | Yield |
---|---|
With pyridine In dichloromethane Cooling with ice; | 17% |
L-α-[[[(4-methoxyphenyl)-methoxy]carbonyl]amino]-2-thiopheneacetic acid
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
(6R)-7c-methoxy-7t-[(Ξ)-2-(4-methoxy-benzyloxycarbonylamino)-2-thiophen-2-yl-acetylamino]-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
(i) diisopropylethylamine, isobutyl chloroformate, CH2Cl2, (ii) /BRN= 5406406/; Multistep reaction; |
cyanomethylmercapto acetyl chloride
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
Cefmetazole
Conditions | Yield |
---|---|
(i) PhNEt2, 1,2-dichloroethane, (ii) CF3CO2H, anisole; Multistep reaction; |
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
(6R)-7c-methoxy-7t-[2-(1-methyl-4-nitro-1H-imidazol-2-ylsulfanyl)-acetylamino]-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Conditions | Yield |
---|---|
(i) PhNEt2, 1,2-dichloro-ethane, (ii) CF3CO2H, anisole; Multistep reaction; |
(3-methyl-5-nitro-3H-imidazol-4-ylsulfanyl)-acetyl chloride
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
(6R)-7c-methoxy-7t-[2-(3-methyl-5-nitro-3H-imidazol-4-ylsulfanyl)-acetylamino]-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Conditions | Yield |
---|---|
(i) PhNEt2, 1,2-dichloro-ethane, (ii) CF3CO2H, anisole; Multistep reaction; |
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
(6R)-7c-methoxy-7t-[2-(1-methyl-5-nitro-1H-imidazol-2-ylsulfanyl)-acetylamino]-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Conditions | Yield |
---|---|
(i) PhNEt2, 1,2-dichloro-ethane, (ii) CF3CO2H, anisole; Multistep reaction; |
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
(6R)-7c-methoxy-7t-[2-(1-methyl-5-nitro-1H-imidazol-4-ylsulfanyl)-acetylamino]-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Conditions | Yield |
---|---|
(i) PhNEt2, 1,2-dichloro-ethane, (ii) CF3CO2H, anisole; Multistep reaction; |
(R)-2-amino-4-thiophen-2-yl-4H-oxazol-5-one; hydrochloride
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
(6R)-7c-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-7t-((R)-2-thiophen-2-yl-2-ureido-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
With methyloxirane In dichloromethane; N,N-dimethyl-formamide |
(S)-2-amino-4-thiophen-2-yl-4H-oxazol-5-one; hydrochloride
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
(6R)-7c-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-7t-((S)-2-thiophen-2-yl-2-ureido-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
With methyloxirane In dichloromethane; N,N-dimethyl-formamide |
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
Carbonic acid benzyl ester 4-chlorocarbonylmethyl-phenyl ester
(6R,7S)-7-[2-(4-Benzyloxycarbonyloxy-phenyl)-acetylamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 0℃; for 0.5h; Yield given; |
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 75 percent / pyridine 2: 100 percent / AlCl3, anisole / 0.5 h / 0 °C View Scheme |
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: (i) diisopropylethylamine, isobutyl chloroformate, CH2Cl2, (ii) /BRN= 5406406/ 2: CF3CO2H, anisole View Scheme |
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
(6R)-7c-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-7t-((S)-2-thiophen-2-yl-2-ureido-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: propyleneoxide / CH2Cl2; dimethylformamide 2: CF3CO2H, anisole / CH2Cl2 View Scheme |
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
(6R)-7c-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-7t-((R)-2-thiophen-2-yl-2-ureido-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: propyleneoxide / CH2Cl2; dimethylformamide 2: CF3CO2H, anisole / CH2Cl2 View Scheme |
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
2-Bromoacetyl bromide
7-bromoacetamide-7-methoxy-3-(1-methyl-1H-5-tetrazolyl)thiomethyl-3-cephem-4-carboxylic acid diphenyl methyl ester
Conditions | Yield |
---|---|
Stage #1: diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate; 2-Bromoacetyl bromide With pyridine In dichloromethane at -30 - -20℃; for 1h; Stage #2: With N-Bromosuccinimide In methanol; dichloromethane at 0 - 5℃; for 1h; | |
With N,N-dimethyl-aniline In ethyl acetate at -5 - 0℃; |
methanol
(6R-cis)-7-amino-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-7-(methylthio)-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester
diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate
2-Bromoacetyl bromide
7-bromoacetamide-7-methoxy-3-(1-methyl-1H-5-tetrazolyl)thiomethyl-3-cephem-4-carboxylic acid diphenyl methyl ester
Conditions | Yield |
---|---|
Stage #1: (6R-cis)-7-amino-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-7-(methylthio)-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenylmethyl ester; diphenylmethyl (6R,7S)-7-amino-7-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-Δ3-cephem-4-carboxylate; 2-Bromoacetyl bromide With pyridine In dichloromethane at -30 - -20℃; for 1h; Stage #2: In dichloromethane; water at 0 - 5℃; Stage #3: methanol With N-Bromosuccinimide; sodium thiosulfate Purification / work up; more than 3 stages; |
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