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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 7-Amino-3-Methoxycephalosporanic Acid(7-Amca) supplier in China

Cas:957-68-6

Min.Order:0 Metric Ton

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Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% 7-Aminocephalosporanic acid 957-68-6 GMP Manufacturer

Cas:957-68-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. Near 20 years DayangChem has provi

High purity 7-Aminocephalosporanic acid 98% TOP1 supplier

Cas:957-68-6

Min.Order:100 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

7-Aminocephalosporanic acid

Cas:957-68-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:7-Aminocephalosporanic acid CAS NO: 957-68-6 Grade:Medical scientific research and export Molecular formula:C10H12N2O5S Molecular weight:272.2777 Product Quality 12 years of chemical raw materials Mature operation of the industry Syst

7-Aminocephalosporanic acid/cas:957-68-6/Raw material spot

Cas:957-68-6

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/796.html Product Name 7-Aminocephalosporanic acid CAS No. 957-68-6

7-Aminocephalosporanic acid

Cas:957-68-6

Min.Order:1 Gram

FOB Price: $34.0 / 43.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

7-Aminocephalosporanic acid

Cas:957-68-6

Min.Order:1 Gram

FOB Price: $1000.0 / 1300.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 957-68-6 with best quality

Cas:957-68-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TIANFUCHEM--957-68-6---7-Aminocephalosporanic acid

Cas:957-68-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name 7-Aminocephalosporanic acid Synonyms (6r,7s)-3-(acetyloxymethyl)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;7-AMINOCEPHALOSPORANIC

7-Aminocephalosporanic acid

Cas:957-68-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White to off-white powder Storage:2-8°C Package:25kg/drum Application:Potent antibacterial that inhibits bacterial transpeptidase and β-lactamase activity in Staphylococcus aureus. Transportation:Express/Sea/Air Port:any port in china

7-Aminocephalosporanic acid factory price

Cas:957-68-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High qu

99% 7-Aminocephalosporanic acid;7-ACA 957-68-6

Cas:957-68-6

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:storage in a dr

Hotsale 7-Aminocephalosporanic acid 98.0%

Cas:957-68-6

Min.Order:1 Kilogram

FOB Price: $11.0

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

7-Aminocephalosporanic acid Basic information Product Name: 7-Aminocephalosporanic acid Synonyms: Cefazolin Sodium EP Impurity H (7-Aminocephalosporanic Acid);Cephalothin Impurity C(EP)(7-ACA);Aminocephalosporanic;Cefazolin EP Impurity H;7-ACA

7-Aminocephalosporanic acid.

Cas:957-68-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Leader Biochemical Group

Overview of Our Factories Our Factories production lines Our Factories R&D ability Our Factories warehouse Our Factorie

China Biggest Factory & Manufacturer supply 7-Aminocephalosporanic Acid/7-ACA

Cas:957-68-6

Min.Order:1 Metric Ton

FOB Price: $30.0 / 35.0

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

7-Aminocephalosporanic acid cephalosporins

Cas:957-68-6

Min.Order:1 Kilogram

FOB Price: $70.0 / 100.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

7-Aminocephalosporanic acid CAS:957-68-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

7-Aminocephalosporanic acid CAS:957-68-6

Cas:957-68-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

7-ACA

Cas:957-68-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

7-Aminocephalosporanic acid CAS 957-68-6

Cas:957-68-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:957-68-6

Cas:957-68-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Triumph International Development Limilted

Appearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:As customer request Port:Qingda

7-Aminocephalosporanic Acid 957-68-6

Cas:957-68-6

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Lab/Research institutions

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Wuhan ZeShanCheng Biomedical Technology Co., Ltd.

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qu

7-Aminocephalosporanic acid

Cas:957-68-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

7-Aminocephalosporanic acid

Cas:957-68-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

7-Aminocephalosporanic acid

Cas:957-68-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hefei Zhaobo Technology Co., Ltd.

Our Advantages Production: Advanced chemical equipment with years of experience.Staffs for producing various extract products. Quality Control:A complete set of Testing Professional and Analysis Equipment ensures the Quality Requirements and Speci

7-Amino-3-Methoxycephalosporanic Acid(7-Amca)CAS 957-68-6

Cas:957-68-6

Min.Order:1 Kilogram

FOB Price: $150.0 / 180.0

Type:Trading Company

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 7-Amino-3-Methoxycephalosporanic Acid(7-Amca)

Cas:957-68-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

957-68-6Appearance:Write or almost white crystalline powder Storage:Store in dry, dark and ventilated place Package:according to customers' requirements Application:Pharmaceutical Intermediates / Active Pharmaceutical Ingredients / For Chemical Resea

7-Aminocephalosporanic acid

Cas:957-68-6

Min.Order:1 Gram

Negotiable

Type:Other

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediates Tr

7-Aminocephalosporanic acid

Cas:957-68-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

7-Aminocephalosporanic acid

Cas:957-68-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

cephalosporin C
61-24-5

cephalosporin C

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

Conditions
ConditionsYield
With phosphate buffer; enzyme derivative DAO; enzyme derivative GA at 25℃; for 2h; pH 8;96%
With glutaryl acylase; D-aminoacid oxidase In water for 2.5h; pH = 8, O2;96%
With D-amino acid oxidase; glutaryl acylase; oxygen In phosphate buffer at 25℃; for 3h; pH=8;
benzhydryl 7-aminocephalosporanate
27266-61-1, 54600-89-4

benzhydryl 7-aminocephalosporanate

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

Conditions
ConditionsYield
With formic acid at 40 - 45℃; for 0.5h; Product distribution;84%
cephalosporin C
61-24-5

cephalosporin C

A

2-oxohexanedioic acid
3184-35-8

2-oxohexanedioic acid

B

7β-(5-carboxy-5-oxopentanamido)cephalosporanic acid
28242-83-3

7β-(5-carboxy-5-oxopentanamido)cephalosporanic acid

C

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

Conditions
ConditionsYield
With sodium hydroxide; D-amino acid oxidase; bovine catalase (on glyoxyl agarose); glutaryl acylase (immobilized on polyethyleneimine) In phosphate buffer at 25℃; for 3h; pH=8; Enzymatic reaction;A n/a
B 2.5%
C 80%
acetic acid
64-19-7

acetic acid

2-(Amino-propylcarbamoyl-methyl)-5-methylene-5,6-dihydro-2H-[1,3]thiazine-4-carboxylic acid

2-(Amino-propylcarbamoyl-methyl)-5-methylene-5,6-dihydro-2H-[1,3]thiazine-4-carboxylic acid

A

propylamine
107-10-8

propylamine

B

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

Conditions
ConditionsYield
With potassium chloride In water at 30℃; Equilibrium constant;
3-acetoxymethyl-7(R)-glutaroylaminoceph-3-em-4-carboxylic acid
27920-90-7

3-acetoxymethyl-7(R)-glutaroylaminoceph-3-em-4-carboxylic acid

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

Conditions
ConditionsYield
With sodium hydroxide; glutaryl-7-aminocephalosporanic acid acylase In water at 25℃; pH=8.0; Enzyme kinetics; Enzymatic reaction;
With water at 37℃; for 0.5h; pH=7.5; Kinetics; Reagent/catalyst; aq. phosphate buffer; Enzymatic reaction;
With recombinant VAC enzyme at 25℃; for 0.166667h; pH=8; Kinetics; Reagent/catalyst; aq. buffer; Enzymatic reaction;
3-acetoxymethyl-7(R)-glutaroylaminoceph-3-em-4-carboxylic acid
27920-90-7

3-acetoxymethyl-7(R)-glutaroylaminoceph-3-em-4-carboxylic acid

A

1,5-pentanedioic acid
110-94-1

1,5-pentanedioic acid

B

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

Conditions
ConditionsYield
With sodium hydroxide; glutaryl acylase (immobilized on polyethyleneimine) In phosphate buffer at 25℃; for 0.5h; pH=8.0; Enzymatic reaction;
7β-(5-carboxy-5-oxopentanamido)cephalosporanic acid
28242-83-3

7β-(5-carboxy-5-oxopentanamido)cephalosporanic acid

A

2-oxohexanedioic acid
3184-35-8

2-oxohexanedioic acid

B

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

Conditions
ConditionsYield
With sodium hydroxide; glutaryl acylase (immobilized on polyethyleneimine) In phosphate buffer at 25℃; for 0.5h; pH=8.0; Enzymatic reaction;
7-[(2-carbomethoxy-1-methylethylene)amino]-3-hydroxymethyl-3-cephem-4-carboxylic acid potassium salt

7-[(2-carbomethoxy-1-methylethylene)amino]-3-hydroxymethyl-3-cephem-4-carboxylic acid potassium salt

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

Conditions
ConditionsYield
With hydrogenchloride; 2-(Dimethylamino)pyridine; potassium hydroxide; acetic anhydride In water; ethyl acetate; acetone
(6R)-3-acetoxymethyl-7t-((R)-5-amino-5-carboxy-pentanoylamino)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; monosodium salt
51762-04-0

(6R)-3-acetoxymethyl-7t-((R)-5-amino-5-carboxy-pentanoylamino)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; monosodium salt

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

Conditions
ConditionsYield
With water at 25℃; pH=8; aq. phosphate buffer; Enzymatic reaction;
7β-(5-carboxy-5-oxopentanamido)cephalosporanic acid
28242-83-3

7β-(5-carboxy-5-oxopentanamido)cephalosporanic acid

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

Conditions
ConditionsYield
With water at 37℃; for 1h; pH=7.5; Kinetics; Reagent/catalyst; aq. phosphate buffer; Enzymatic reaction;
(6R)-3-acetoxymethyl-8-oxo-7t-pentanoylamino-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
3595-18-4

(6R)-3-acetoxymethyl-8-oxo-7t-pentanoylamino-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

Conditions
ConditionsYield
With recombinant VAC enzyme at 25℃; for 0.166667h; pH=8; Kinetics; Reagent/catalyst; aq. buffer; Enzymatic reaction;
(6R,7R)-3-Acetoxymethyl-7-(3-carboxy-propionylamino)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-3-Acetoxymethyl-7-(3-carboxy-propionylamino)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

Conditions
ConditionsYield
With recombinant VAC enzyme at 25℃; for 0.166667h; pH=8; Kinetics; Reagent/catalyst; aq. buffer; Enzymatic reaction;
glutaryl-7-aminocephalosporanic acid

glutaryl-7-aminocephalosporanic acid

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

Conditions
ConditionsYield
With recombinant VAC enzyme at 25℃; for 0.166667h; pH=8; Kinetics; Reagent/catalyst; aq. buffer; Enzymatic reaction;
2-methyl-3-mercapto-5-oxo-6-hydroxy-2,5-dihydro-1,2,4-triazine
58909-39-0

2-methyl-3-mercapto-5-oxo-6-hydroxy-2,5-dihydro-1,2,4-triazine

2-(2-amino-1,3-thiazol-4-yl)-1-(1,3-benzothiazol-2-ylsulfanyl)-2-(methoxyimino)ethan-1-one
94088-75-2

2-(2-amino-1,3-thiazol-4-yl)-1-(1,3-benzothiazol-2-ylsulfanyl)-2-(methoxyimino)ethan-1-one

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

ceftriaxone sodium

ceftriaxone sodium

Conditions
ConditionsYield
Stage #1: 2-methyl-3-mercapto-5-oxo-6-hydroxy-2,5-dihydro-1,2,4-triazine; 7-Aminocephalosporanic acid With carbonic acid dimethyl ester at 35℃; for 1h;
Stage #2: 2-(2-amino-1,3-thiazol-4-yl)-1-(1,3-benzothiazol-2-ylsulfanyl)-2-(methoxyimino)ethan-1-one for 0.166667h;
Stage #3: With triethylamine at 10℃; for 4h; Concentration; Temperature;
99.5%
furane-2-monocarboxylic acid
4741-45-1

furane-2-monocarboxylic acid

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

(6R,7R)-7-amino-3-(furan-2-carbonylsulfanylmethyl)cephalosporanic acid

(6R,7R)-7-amino-3-(furan-2-carbonylsulfanylmethyl)cephalosporanic acid

Conditions
ConditionsYield
With gamma-Al2O2-O22-Na+; zeolite In water at 20℃; for 2h; Large scale;99.4%
With solid base catalyst; zeolite In water at 20℃; for 2h; Large scale;99.1%
2,3-cyclopentenopyridine
533-37-9

2,3-cyclopentenopyridine

(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate
80756-85-0

(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

cefpirome Sulfate
98753-19-6

cefpirome Sulfate

Conditions
ConditionsYield
With sulfuric acid for 0.0666667h; Time; Microwave irradiation;99%
pyridine
110-86-1

pyridine

(Z)-(2-carboxyprop-2-oxyimino)-2-(2-aminothiazole-4-yl)-acetylchloride monohydrochloride
354808-44-9

(Z)-(2-carboxyprop-2-oxyimino)-2-(2-aminothiazole-4-yl)-acetylchloride monohydrochloride

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

Conditions
ConditionsYield
at -16℃; for 2h; Concentration; Temperature; Sonication; Industrial scale;98.9%
1-methyl-5-mercaptotetrazole
13183-79-4

1-methyl-5-mercaptotetrazole

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

(6R,7R)-7-amino-3-[(1H-1-methyltetrazol-5-yl)thio]methylceph-3-em-4-carboxylic acid
24209-38-9

(6R,7R)-7-amino-3-[(1H-1-methyltetrazol-5-yl)thio]methylceph-3-em-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: 1-methyl-5-mercaptotetrazole With boron trifluoride dimethyl carbonate complex; carbonic acid dimethyl ester at 10 - 12℃; for 0.166667h;
Stage #2: 7-Aminocephalosporanic acid at 25℃; for 0.75h;
Stage #3: With chloroacetyl chloride In N,N-dimethyl-formamide at 0℃; for 0.75h;
98%
With pyridine; tetrabutoxytitanium; titanium tetrachloride In acetonitrile at 5 - 30℃; for 3h; Reagent/catalyst;98%
With boron trifluoride In acetonitrile at 30℃; for 1.5h;94.7%
7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

(1H-tetrazol-1-yl)-2-acetic acid methyl ester
55633-19-7

(1H-tetrazol-1-yl)-2-acetic acid methyl ester

7-((tetrazol-1'-yl)acetylamino)-3-acetyloxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
32510-61-5

7-((tetrazol-1'-yl)acetylamino)-3-acetyloxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With phosphate buffer; PGA E. coli A at 4℃; pH 6.5;98%
With penicillin G acylase In water at 4℃; pH = 6.5;98%
C10H7Cl2N3O2S2

C10H7Cl2N3O2S2

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

(6R,7R)-3-[[(5-methyl-1,3,4-thiadiazolyl-2-yl)thio]methyl]-7-[2-(3,5-dichloro-4-pyridone-1-acetylamido)]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
63521-15-3

(6R,7R)-3-[[(5-methyl-1,3,4-thiadiazolyl-2-yl)thio]methyl]-7-[2-(3,5-dichloro-4-pyridone-1-acetylamido)]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt

Conditions
ConditionsYield
Stage #1: C10H7Cl2N3O2S2; 7-Aminocephalosporanic acid With sodium hydroxide In water; acetonitrile at 30℃; for 3h;
Stage #2: With sodium hydrogencarbonate; pyrographite In water; acetonitrile at 30 - 40℃; for 2h; pH=8;
97.5%
7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

(3-Mercapto-5-methyl-[1,2,4]triazol-4-yl)-acetic acid ethyl ester

(3-Mercapto-5-methyl-[1,2,4]triazol-4-yl)-acetic acid ethyl ester

(6R,7R)-7-Amino-3-(4-ethoxycarbonylmethyl-5-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-7-Amino-3-(4-ethoxycarbonylmethyl-5-methyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With boron trifluoride97%
5-methyl-1,2,3,4-tetrazole
4076-36-2

5-methyl-1,2,3,4-tetrazole

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

7-amino-3-[2-(5-methyl-2H-tetrazolyl)methyl]cephalosporanic acid

7-amino-3-[2-(5-methyl-2H-tetrazolyl)methyl]cephalosporanic acid

Conditions
ConditionsYield
Stage #1: 5-methyl-1,2,3,4-tetrazole With sulfuric acid at 20℃; for 0.333333h;
Stage #2: 7-Aminocephalosporanic acid at 20℃; Reagent/catalyst;
96.21%
With borane-THF In tetrahydrofuran at 55℃; for 6h; Temperature; Concentration;95%
7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

{(Z)-3-[4-Benzhydryloxy-5-(4-methoxy-benzyloxy)-1-oxy-pyridin-2-yl]-isoxazol-5-ylmethoxyimino}-[2-(trityl-amino)-thiazol-4-yl]-acetic acid
159048-31-4

{(Z)-3-[4-Benzhydryloxy-5-(4-methoxy-benzyloxy)-1-oxy-pyridin-2-yl]-isoxazol-5-ylmethoxyimino}-[2-(trityl-amino)-thiazol-4-yl]-acetic acid

(6R,7R)-3-Acetoxymethyl-7-{2-{(Z)-3-[4-benzhydryloxy-5-(4-methoxy-benzyloxy)-1-oxy-pyridin-2-yl]-isoxazol-5-ylmethoxyimino}-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
1026067-80-0

(6R,7R)-3-Acetoxymethyl-7-{2-{(Z)-3-[4-benzhydryloxy-5-(4-methoxy-benzyloxy)-1-oxy-pyridin-2-yl]-isoxazol-5-ylmethoxyimino}-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With pyridine; trichlorophosphate Substitution;96%
7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

phenylacetyl chloride
103-80-0

phenylacetyl chloride

cephaloram
859-07-4

cephaloram

Conditions
ConditionsYield
Stage #1: 7-Aminocephalosporanic acid With sodium carbonate In water; acetone at -5℃; for 0.166667h; Schotten-Baumann reaction;
Stage #2: phenylacetyl chloride In water; acetone for 4h; Schotten-Baumann reaction;
Stage #3: With hydrogenchloride In water; ethyl acetate; acetone pH=3 - 3.5;
96%
With sodium hydrogencarbonate In acetone at 20℃; for 17h; pH=8.0; Schotten-Baumann method;83%
Stage #1: 7-Aminocephalosporanic acid; phenylacetyl chloride With sodium hydrogencarbonate In water; acetone at 20℃; for 16h; Schotten-Baumann reaction;
Stage #2: With hydrogenchloride In dichloromethane; water; acetone pH=2;
55%
oxalyl dichloride
79-37-8

oxalyl dichloride

2-t-butoxycarbonylmethoxyimino-2-(fur-2-yl)acetic acid

2-t-butoxycarbonylmethoxyimino-2-(fur-2-yl)acetic acid

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

(6R)-3-acetoxymethyl-7t-(2-(Z)-tert-butoxycarbonylmethoxyimino-2-furan-2-yl-acetylamino)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
56869-87-5

(6R)-3-acetoxymethyl-7t-(2-(Z)-tert-butoxycarbonylmethoxyimino-2-furan-2-yl-acetylamino)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In N-methyl-acetamide; dichloromethane; water; triethylamine; acetone96%
With sodium hydrogencarbonate In N-methyl-acetamide; dichloromethane; water; triethylamine; acetone96%
2-mercapto-1,3,4-thiadiazole
18686-82-3

2-mercapto-1,3,4-thiadiazole

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

C10H10N4O3S3*ClH

C10H10N4O3S3*ClH

Conditions
ConditionsYield
Stage #1: 2-mercapto-1,3,4-thiadiazole; 7-Aminocephalosporanic acid With boron trifluoride dimethyl carbonate complex; carbonic-acid; carbonic acid dimethyl ester at 0 - 10℃; for 1h;
Stage #2: With hydrogenchloride In water at -5 - 0℃; Reagent/catalyst;
96%
C14H20N2O6S2
153012-24-9

C14H20N2O6S2

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

7β-<(Z)-2-(2-tert-butoxycarbonylaminothiazol-4-yl)-2-pentenoylamino>-3-acetoxymethyl-3-cephem-4-carboxylic acid
107185-27-3

7β-<(Z)-2-(2-tert-butoxycarbonylaminothiazol-4-yl)-2-pentenoylamino>-3-acetoxymethyl-3-cephem-4-carboxylic acid

Conditions
ConditionsYield
With diisopropylamine; rac-Pro-OH In methanol at 15 - 20℃; Temperature;95.8%
2-methyl-3-mercapto-5-oxo-6-hydroxy-2,5-dihydro-1,2,4-triazine
58909-39-0

2-methyl-3-mercapto-5-oxo-6-hydroxy-2,5-dihydro-1,2,4-triazine

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

Conditions
ConditionsYield
With boron trifluoride dimethyl carbonate complex; methanesulfonic acid at 10 - 12℃; for 0.383333h; Reagent/catalyst;95.1%
With boron trifluoride dimethyl carbonate complex; edetate disodium at 30℃; for 0.833333h; Time;90%
With boron trifluoride In acetonitrile at 10 - 30℃; for 0.5h;85.71%
1-methyl-5-mercaptotetrazole
13183-79-4

1-methyl-5-mercaptotetrazole

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

C10H14N6O3S2

C10H14N6O3S2

Conditions
ConditionsYield
Stage #1: 1-methyl-5-mercaptotetrazole; 7-Aminocephalosporanic acid With boron trifluoride In acetonitrile at 35 - 39℃;
Stage #2: With hydrogenchloride In water; acetonitrile at 10 - 32℃; for 0.666667h; Reagent/catalyst;
95.1%
Stage #1: 1-methyl-5-mercaptotetrazole With acetonitrile boron trifluoride complex at 30℃; for 0.5h;
Stage #2: 7-Aminocephalosporanic acid at 30℃; for 1h;
AE-active thioester

AE-active thioester

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

Conditions
ConditionsYield
Stage #1: 7-Aminocephalosporanic acid With triethylamine In dichloromethane at 2 - 4℃; for 0.5h; Inert atmosphere;
Stage #2: AE-active thioester In dichloromethane at 2 - 4℃; for 1h; Temperature;
95.1%
2-mercapto-5-methyl-1,3,4-thiadiazole
29490-19-5

2-mercapto-5-methyl-1,3,4-thiadiazole

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

(6R,7R)-7-amino-3-(5-methyl-1,3,4-thiadiazol-2-ylthiomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
30246-33-4

(6R,7R)-7-amino-3-(5-methyl-1,3,4-thiadiazol-2-ylthiomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With boron trifluoride dimethyl carbonate complex; acetic acid at 5 - 10℃; Temperature;95%
With boron trifluoride dimethyl carbonate complex; carbonic acid dimethyl ester at 20 - 30℃; for 1h; Reagent/catalyst;92.1%
With boron trifluoride In acetonitrile at 30℃; for 1.5h;86%
(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate
80756-85-0

(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

cefotaxime
63527-52-6

cefotaxime

Conditions
ConditionsYield
With TEA In dichloromethane at 20℃; for 1h; Substitution;95%
With triethylamine In dichloromethane at 20℃; for 1h;95%
Stage #1: (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate; 7-Aminocephalosporanic acid With triethylamine In methanol at 0 - 5℃;
Stage #2: With hydrogenchloride In methanol; water at 0 - 5℃; for 1h; pH=2.3 - 2.5;
Stage #1: (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate; 7-Aminocephalosporanic acid With triethylamine In 1,2-dimethoxyethane at -5 - 0℃;
Stage #2: With hydrogenchloride In 1,2-dimethoxyethane; water for 1h; pH=2.6 - 2.8; Product distribution / selectivity;
2-mercapto-1,3,4-thiadiazole
18686-82-3

2-mercapto-1,3,4-thiadiazole

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

7-amino-3-[2-(1,3,4)-thiadiazolyl]thiomethyl-3-cephem-4-carboxylic acid
24209-43-6

7-amino-3-[2-(1,3,4)-thiadiazolyl]thiomethyl-3-cephem-4-carboxylic acid

Conditions
ConditionsYield
With boron trifluoride dimethyl carbonate complex; carbonic-acid; carbonic acid dimethyl ester at 0 - 10℃; under 2 Torr; Reagent/catalyst;95%
With hydrogenchloride; boron trifluoride dimethyl carbonate complex In dichloromethane at 20 - 30℃; pH=3.5; Reagent/catalyst; Large scale;93%
2-mercapto-5-methyl-1,3,4-thiadiazole
29490-19-5

2-mercapto-5-methyl-1,3,4-thiadiazole

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

C11H12N4O3S3*ClH

C11H12N4O3S3*ClH

Conditions
ConditionsYield
With boron trifluoride diethyl etherate; acetic acid at 5 - 10℃; Temperature;95%
7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

2,6-dimethyl-5-oxo-1,2,4-triazine-3-thiol

2,6-dimethyl-5-oxo-1,2,4-triazine-3-thiol

7-amino-3-[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazine-3-mercapto)methyl]-3 cephalosporin-4-carboxylic acid
58909-56-1

7-amino-3-[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazine-3-mercapto)methyl]-3 cephalosporin-4-carboxylic acid

Conditions
ConditionsYield
With titanium tetrachloride; tetrabutyl titanium; N-ethyl-N,N-diisopropylamine In dichloromethane at 5℃; for 4h;95%
benzothiazol-2-yl-2-(2-amino-4-thiazolyl)-2(Z)-methoxyiminoacetate

benzothiazol-2-yl-2-(2-amino-4-thiazolyl)-2(Z)-methoxyiminoacetate

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

7-amino-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-3-cephem-4-carboxylic acid hydrochloride
68350-02-7

7-amino-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-3-cephem-4-carboxylic acid hydrochloride

Conditions
ConditionsYield
Stage #1: benzothiazol-2-yl-2-(2-amino-4-thiazolyl)-2(Z)-methoxyiminoacetate; 7-Aminocephalosporanic acid With boron trifluoride In acetonitrile at 5 - 50℃; for 3.5h; Large scale;
Stage #2: With hydrogenchloride In water; acetonitrile at 18℃; for 1h; Large scale;
95%
diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate

diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

cefotaxime
63527-52-6

cefotaxime

Conditions
ConditionsYield
Stage #1: 7-Aminocephalosporanic acid With N,O-bis-(trimethylsilyl)-acetamide In dichloromethane at 20℃; for 1h;
Stage #2: diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate In dichloromethane at 20℃; for 8h;
Stage #3: With sodium hydroxide In dichloromethane; water at 15 - 20℃; pH=7.5 - 7.8;
94.4%
Stage #1: 7-Aminocephalosporanic acid With N,O-bis-(trimethylsilyl)-acetamide In DMF (N,N-dimethyl-formamide) at 20 - 25℃;
Stage #2: diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate In DMF (N,N-dimethyl-formamide) at 20℃; for 18h;
93.5%
chloroacetyl chloride
79-04-9

chloroacetyl chloride

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

7-chloroacetamidocephalosporanic acid
28240-16-6

7-chloroacetamidocephalosporanic acid

Conditions
ConditionsYield
Stage #1: 7-Aminocephalosporanic acid With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane In dichloromethane at 20℃; for 1h;
Stage #2: chloroacetyl chloride With copper(I) oxide at 0 - 20℃; for 1h;
94%
With sodium hydrogencarbonate In water; acetone for 3h;88.4%
In ethyl acetate
S(4),5,5-trimethyldithiohydantoin
124876-25-1

S(4),5,5-trimethyldithiohydantoin

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

(6R,7R)-7-Amino-3-(4,4-dimethyl-5-methylsulfanyl-4H-imidazol-2-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
124876-28-4

(6R,7R)-7-Amino-3-(4,4-dimethyl-5-methylsulfanyl-4H-imidazol-2-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With chlorosulfonic acid In acetonitrile at 0℃;94%
dichloroacethyl chloride
79-36-7

dichloroacethyl chloride

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

(6R)-3-acetoxymethyl-7t-(2,2-dichloro-acetylamino)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
28307-26-8

(6R)-3-acetoxymethyl-7t-(2,2-dichloro-acetylamino)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: 7-Aminocephalosporanic acid With sodium hydrogencarbonate In water at 0 - 35℃;
Stage #2: dichloroacethyl chloride In water at 0 - 5℃; for 0.5h; Reagent/catalyst;
93.6%
C21H16N6O3S

C21H16N6O3S

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

cefotaxime
63527-52-6

cefotaxime

Conditions
ConditionsYield
With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile at -5 - 0℃; for 1h; Temperature;93.1%
indole-3-acetic acid
87-51-4

indole-3-acetic acid

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

7-((indol-3'-yl)-acetylamino)-3-acetyloxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

7-((indol-3'-yl)-acetylamino)-3-acetyloxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With aluminum oxide for 0.0333333h; microwave irradiation;93%
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