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Cas:957-68-6
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryDayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. Near 20 years DayangChem has provi
Cas:957-68-6
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryName:7-Aminocephalosporanic acid CAS NO: 957-68-6 Grade:Medical scientific research and export Molecular formula:C10H12N2O5S Molecular weight:272.2777 Product Quality 12 years of chemical raw materials Mature operation of the industry Syst
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/796.html Product Name 7-Aminocephalosporanic acid CAS No. 957-68-6
Cas:957-68-6
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryProduct Name 7-Aminocephalosporanic acid Synonyms (6r,7s)-3-(acetyloxymethyl)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;7-AMINOCEPHALOSPORANIC
Appearance:White to off-white powder Storage:2-8°C Package:25kg/drum Application:Potent antibacterial that inhibits bacterial transpeptidase and β-lactamase activity in Staphylococcus aureus. Transportation:Express/Sea/Air Port:any port in china
Cas:957-68-6
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inquiryOur Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High qu
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inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:storage in a dr
Cas:957-68-6
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inquiry7-Aminocephalosporanic acid Basic information Product Name: 7-Aminocephalosporanic acid Synonyms: Cefazolin Sodium EP Impurity H (7-Aminocephalosporanic Acid);Cephalothin Impurity C(EP)(7-ACA);Aminocephalosporanic;Cefazolin EP Impurity H;7-ACA
Cas:957-68-6
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inquiryOverview of Our Factories Our Factories production lines Our Factories R&D ability Our Factories warehouse Our Factorie
Cas:957-68-6
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:957-68-6
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inquiry7-Aminocephalosporanic acid CAS:957-68-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic
Cas:957-68-6
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:957-68-6
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Appearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:As customer request Port:Qingda
Cas:957-68-6
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inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qu
Cas:957-68-6
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:957-68-6
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryOur Advantages Production: Advanced chemical equipment with years of experience.Staffs for producing various extract products. Quality Control:A complete set of Testing Professional and Analysis Equipment ensures the Quality Requirements and Speci
Cas:957-68-6
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:957-68-6
Min.Order:10 Gram
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inquiry957-68-6Appearance:Write or almost white crystalline powder Storage:Store in dry, dark and ventilated place Package:according to customers' requirements Application:Pharmaceutical Intermediates / Active Pharmaceutical Ingredients / For Chemical Resea
Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediates Tr
Cas:957-68-6
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inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Cas:957-68-6
Min.Order:10 Gram
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Type:Lab/Research institutions
inquiryConditions | Yield |
---|---|
With phosphate buffer; enzyme derivative DAO; enzyme derivative GA at 25℃; for 2h; pH 8; | 96% |
With glutaryl acylase; D-aminoacid oxidase In water for 2.5h; pH = 8, O2; | 96% |
With D-amino acid oxidase; glutaryl acylase; oxygen In phosphate buffer at 25℃; for 3h; pH=8; |
benzhydryl 7-aminocephalosporanate
7-Aminocephalosporanic acid
Conditions | Yield |
---|---|
With formic acid at 40 - 45℃; for 0.5h; Product distribution; | 84% |
cephalosporin C
A
2-oxohexanedioic acid
B
7β-(5-carboxy-5-oxopentanamido)cephalosporanic acid
C
7-Aminocephalosporanic acid
Conditions | Yield |
---|---|
With sodium hydroxide; D-amino acid oxidase; bovine catalase (on glyoxyl agarose); glutaryl acylase (immobilized on polyethyleneimine) In phosphate buffer at 25℃; for 3h; pH=8; Enzymatic reaction; | A n/a B 2.5% C 80% |
Conditions | Yield |
---|---|
With potassium chloride In water at 30℃; Equilibrium constant; |
3-acetoxymethyl-7(R)-glutaroylaminoceph-3-em-4-carboxylic acid
7-Aminocephalosporanic acid
Conditions | Yield |
---|---|
With sodium hydroxide; glutaryl-7-aminocephalosporanic acid acylase In water at 25℃; pH=8.0; Enzyme kinetics; Enzymatic reaction; | |
With water at 37℃; for 0.5h; pH=7.5; Kinetics; Reagent/catalyst; aq. phosphate buffer; Enzymatic reaction; | |
With recombinant VAC enzyme at 25℃; for 0.166667h; pH=8; Kinetics; Reagent/catalyst; aq. buffer; Enzymatic reaction; |
3-acetoxymethyl-7(R)-glutaroylaminoceph-3-em-4-carboxylic acid
A
1,5-pentanedioic acid
B
7-Aminocephalosporanic acid
Conditions | Yield |
---|---|
With sodium hydroxide; glutaryl acylase (immobilized on polyethyleneimine) In phosphate buffer at 25℃; for 0.5h; pH=8.0; Enzymatic reaction; |
7β-(5-carboxy-5-oxopentanamido)cephalosporanic acid
A
2-oxohexanedioic acid
B
7-Aminocephalosporanic acid
Conditions | Yield |
---|---|
With sodium hydroxide; glutaryl acylase (immobilized on polyethyleneimine) In phosphate buffer at 25℃; for 0.5h; pH=8.0; Enzymatic reaction; |
7-Aminocephalosporanic acid
Conditions | Yield |
---|---|
With hydrogenchloride; 2-(Dimethylamino)pyridine; potassium hydroxide; acetic anhydride In water; ethyl acetate; acetone |
(6R)-3-acetoxymethyl-7t-((R)-5-amino-5-carboxy-pentanoylamino)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; monosodium salt
7-Aminocephalosporanic acid
Conditions | Yield |
---|---|
With water at 25℃; pH=8; aq. phosphate buffer; Enzymatic reaction; |
7β-(5-carboxy-5-oxopentanamido)cephalosporanic acid
7-Aminocephalosporanic acid
Conditions | Yield |
---|---|
With water at 37℃; for 1h; pH=7.5; Kinetics; Reagent/catalyst; aq. phosphate buffer; Enzymatic reaction; |
(6R)-3-acetoxymethyl-8-oxo-7t-pentanoylamino-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
7-Aminocephalosporanic acid
Conditions | Yield |
---|---|
With recombinant VAC enzyme at 25℃; for 0.166667h; pH=8; Kinetics; Reagent/catalyst; aq. buffer; Enzymatic reaction; |
7-Aminocephalosporanic acid
Conditions | Yield |
---|---|
With recombinant VAC enzyme at 25℃; for 0.166667h; pH=8; Kinetics; Reagent/catalyst; aq. buffer; Enzymatic reaction; |
7-Aminocephalosporanic acid
Conditions | Yield |
---|---|
With recombinant VAC enzyme at 25℃; for 0.166667h; pH=8; Kinetics; Reagent/catalyst; aq. buffer; Enzymatic reaction; |
2-methyl-3-mercapto-5-oxo-6-hydroxy-2,5-dihydro-1,2,4-triazine
2-(2-amino-1,3-thiazol-4-yl)-1-(1,3-benzothiazol-2-ylsulfanyl)-2-(methoxyimino)ethan-1-one
7-Aminocephalosporanic acid
Conditions | Yield |
---|---|
Stage #1: 2-methyl-3-mercapto-5-oxo-6-hydroxy-2,5-dihydro-1,2,4-triazine; 7-Aminocephalosporanic acid With carbonic acid dimethyl ester at 35℃; for 1h; Stage #2: 2-(2-amino-1,3-thiazol-4-yl)-1-(1,3-benzothiazol-2-ylsulfanyl)-2-(methoxyimino)ethan-1-one for 0.166667h; Stage #3: With triethylamine at 10℃; for 4h; Concentration; Temperature; | 99.5% |
Conditions | Yield |
---|---|
With gamma-Al2O2-O22-Na+; zeolite In water at 20℃; for 2h; Large scale; | 99.4% |
With solid base catalyst; zeolite In water at 20℃; for 2h; Large scale; | 99.1% |
2,3-cyclopentenopyridine
(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate
7-Aminocephalosporanic acid
cefpirome Sulfate
Conditions | Yield |
---|---|
With sulfuric acid for 0.0666667h; Time; Microwave irradiation; | 99% |
pyridine
(Z)-(2-carboxyprop-2-oxyimino)-2-(2-aminothiazole-4-yl)-acetylchloride monohydrochloride
7-Aminocephalosporanic acid
ceftazidime
Conditions | Yield |
---|---|
at -16℃; for 2h; Concentration; Temperature; Sonication; Industrial scale; | 98.9% |
1-methyl-5-mercaptotetrazole
7-Aminocephalosporanic acid
(6R,7R)-7-amino-3-[(1H-1-methyltetrazol-5-yl)thio]methylceph-3-em-4-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 1-methyl-5-mercaptotetrazole With boron trifluoride dimethyl carbonate complex; carbonic acid dimethyl ester at 10 - 12℃; for 0.166667h; Stage #2: 7-Aminocephalosporanic acid at 25℃; for 0.75h; Stage #3: With chloroacetyl chloride In N,N-dimethyl-formamide at 0℃; for 0.75h; | 98% |
With pyridine; tetrabutoxytitanium; titanium tetrachloride In acetonitrile at 5 - 30℃; for 3h; Reagent/catalyst; | 98% |
With boron trifluoride In acetonitrile at 30℃; for 1.5h; | 94.7% |
7-Aminocephalosporanic acid
(1H-tetrazol-1-yl)-2-acetic acid methyl ester
7-((tetrazol-1'-yl)acetylamino)-3-acetyloxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Conditions | Yield |
---|---|
With phosphate buffer; PGA E. coli A at 4℃; pH 6.5; | 98% |
With penicillin G acylase In water at 4℃; pH = 6.5; | 98% |
7-Aminocephalosporanic acid
(6R,7R)-3-[[(5-methyl-1,3,4-thiadiazolyl-2-yl)thio]methyl]-7-[2-(3,5-dichloro-4-pyridone-1-acetylamido)]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
Conditions | Yield |
---|---|
Stage #1: C10H7Cl2N3O2S2; 7-Aminocephalosporanic acid With sodium hydroxide In water; acetonitrile at 30℃; for 3h; Stage #2: With sodium hydrogencarbonate; pyrographite In water; acetonitrile at 30 - 40℃; for 2h; pH=8; | 97.5% |
7-Aminocephalosporanic acid
Conditions | Yield |
---|---|
With boron trifluoride | 97% |
Conditions | Yield |
---|---|
Stage #1: 5-methyl-1,2,3,4-tetrazole With sulfuric acid at 20℃; for 0.333333h; Stage #2: 7-Aminocephalosporanic acid at 20℃; Reagent/catalyst; | 96.21% |
With borane-THF In tetrahydrofuran at 55℃; for 6h; Temperature; Concentration; | 95% |
7-Aminocephalosporanic acid
{(Z)-3-[4-Benzhydryloxy-5-(4-methoxy-benzyloxy)-1-oxy-pyridin-2-yl]-isoxazol-5-ylmethoxyimino}-[2-(trityl-amino)-thiazol-4-yl]-acetic acid
(6R,7R)-3-Acetoxymethyl-7-{2-{(Z)-3-[4-benzhydryloxy-5-(4-methoxy-benzyloxy)-1-oxy-pyridin-2-yl]-isoxazol-5-ylmethoxyimino}-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Conditions | Yield |
---|---|
With pyridine; trichlorophosphate Substitution; | 96% |
Conditions | Yield |
---|---|
Stage #1: 7-Aminocephalosporanic acid With sodium carbonate In water; acetone at -5℃; for 0.166667h; Schotten-Baumann reaction; Stage #2: phenylacetyl chloride In water; acetone for 4h; Schotten-Baumann reaction; Stage #3: With hydrogenchloride In water; ethyl acetate; acetone pH=3 - 3.5; | 96% |
With sodium hydrogencarbonate In acetone at 20℃; for 17h; pH=8.0; Schotten-Baumann method; | 83% |
Stage #1: 7-Aminocephalosporanic acid; phenylacetyl chloride With sodium hydrogencarbonate In water; acetone at 20℃; for 16h; Schotten-Baumann reaction; Stage #2: With hydrogenchloride In dichloromethane; water; acetone pH=2; | 55% |
oxalyl dichloride
7-Aminocephalosporanic acid
(6R)-3-acetoxymethyl-7t-(2-(Z)-tert-butoxycarbonylmethoxyimino-2-furan-2-yl-acetylamino)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In N-methyl-acetamide; dichloromethane; water; triethylamine; acetone | 96% |
With sodium hydrogencarbonate In N-methyl-acetamide; dichloromethane; water; triethylamine; acetone | 96% |
Conditions | Yield |
---|---|
Stage #1: 2-mercapto-1,3,4-thiadiazole; 7-Aminocephalosporanic acid With boron trifluoride dimethyl carbonate complex; carbonic-acid; carbonic acid dimethyl ester at 0 - 10℃; for 1h; Stage #2: With hydrogenchloride In water at -5 - 0℃; Reagent/catalyst; | 96% |
C14H20N2O6S2
7-Aminocephalosporanic acid
7β-<(Z)-2-(2-tert-butoxycarbonylaminothiazol-4-yl)-2-pentenoylamino>-3-acetoxymethyl-3-cephem-4-carboxylic acid
Conditions | Yield |
---|---|
With diisopropylamine; rac-Pro-OH In methanol at 15 - 20℃; Temperature; | 95.8% |
2-methyl-3-mercapto-5-oxo-6-hydroxy-2,5-dihydro-1,2,4-triazine
7-Aminocephalosporanic acid
7-aminoceftrizine
Conditions | Yield |
---|---|
With boron trifluoride dimethyl carbonate complex; methanesulfonic acid at 10 - 12℃; for 0.383333h; Reagent/catalyst; | 95.1% |
With boron trifluoride dimethyl carbonate complex; edetate disodium at 30℃; for 0.833333h; Time; | 90% |
With boron trifluoride In acetonitrile at 10 - 30℃; for 0.5h; | 85.71% |
Conditions | Yield |
---|---|
Stage #1: 1-methyl-5-mercaptotetrazole; 7-Aminocephalosporanic acid With boron trifluoride In acetonitrile at 35 - 39℃; Stage #2: With hydrogenchloride In water; acetonitrile at 10 - 32℃; for 0.666667h; Reagent/catalyst; | 95.1% |
Stage #1: 1-methyl-5-mercaptotetrazole With acetonitrile boron trifluoride complex at 30℃; for 0.5h; Stage #2: 7-Aminocephalosporanic acid at 30℃; for 1h; |
7-Aminocephalosporanic acid
cefotaxime
Conditions | Yield |
---|---|
Stage #1: 7-Aminocephalosporanic acid With triethylamine In dichloromethane at 2 - 4℃; for 0.5h; Inert atmosphere; Stage #2: AE-active thioester In dichloromethane at 2 - 4℃; for 1h; Temperature; | 95.1% |
2-mercapto-5-methyl-1,3,4-thiadiazole
7-Aminocephalosporanic acid
(6R,7R)-7-amino-3-(5-methyl-1,3,4-thiadiazol-2-ylthiomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Conditions | Yield |
---|---|
With boron trifluoride dimethyl carbonate complex; acetic acid at 5 - 10℃; Temperature; | 95% |
With boron trifluoride dimethyl carbonate complex; carbonic acid dimethyl ester at 20 - 30℃; for 1h; Reagent/catalyst; | 92.1% |
With boron trifluoride In acetonitrile at 30℃; for 1.5h; | 86% |
(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate
7-Aminocephalosporanic acid
cefotaxime
Conditions | Yield |
---|---|
With TEA In dichloromethane at 20℃; for 1h; Substitution; | 95% |
With triethylamine In dichloromethane at 20℃; for 1h; | 95% |
Stage #1: (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate; 7-Aminocephalosporanic acid With triethylamine In methanol at 0 - 5℃; Stage #2: With hydrogenchloride In methanol; water at 0 - 5℃; for 1h; pH=2.3 - 2.5; | |
Stage #1: (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate; 7-Aminocephalosporanic acid With triethylamine In 1,2-dimethoxyethane at -5 - 0℃; Stage #2: With hydrogenchloride In 1,2-dimethoxyethane; water for 1h; pH=2.6 - 2.8; Product distribution / selectivity; |
2-mercapto-1,3,4-thiadiazole
7-Aminocephalosporanic acid
7-amino-3-[2-(1,3,4)-thiadiazolyl]thiomethyl-3-cephem-4-carboxylic acid
Conditions | Yield |
---|---|
With boron trifluoride dimethyl carbonate complex; carbonic-acid; carbonic acid dimethyl ester at 0 - 10℃; under 2 Torr; Reagent/catalyst; | 95% |
With hydrogenchloride; boron trifluoride dimethyl carbonate complex In dichloromethane at 20 - 30℃; pH=3.5; Reagent/catalyst; Large scale; | 93% |
2-mercapto-5-methyl-1,3,4-thiadiazole
7-Aminocephalosporanic acid
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate; acetic acid at 5 - 10℃; Temperature; | 95% |
7-Aminocephalosporanic acid
7-amino-3-[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazine-3-mercapto)methyl]-3 cephalosporin-4-carboxylic acid
Conditions | Yield |
---|---|
With titanium tetrachloride; tetrabutyl titanium; N-ethyl-N,N-diisopropylamine In dichloromethane at 5℃; for 4h; | 95% |
7-Aminocephalosporanic acid
7-amino-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-3-cephem-4-carboxylic acid hydrochloride
Conditions | Yield |
---|---|
Stage #1: benzothiazol-2-yl-2-(2-amino-4-thiazolyl)-2(Z)-methoxyiminoacetate; 7-Aminocephalosporanic acid With boron trifluoride In acetonitrile at 5 - 50℃; for 3.5h; Large scale; Stage #2: With hydrogenchloride In water; acetonitrile at 18℃; for 1h; Large scale; | 95% |
7-Aminocephalosporanic acid
cefotaxime
Conditions | Yield |
---|---|
Stage #1: 7-Aminocephalosporanic acid With N,O-bis-(trimethylsilyl)-acetamide In dichloromethane at 20℃; for 1h; Stage #2: diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate In dichloromethane at 20℃; for 8h; Stage #3: With sodium hydroxide In dichloromethane; water at 15 - 20℃; pH=7.5 - 7.8; | 94.4% |
Stage #1: 7-Aminocephalosporanic acid With N,O-bis-(trimethylsilyl)-acetamide In DMF (N,N-dimethyl-formamide) at 20 - 25℃; Stage #2: diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate In DMF (N,N-dimethyl-formamide) at 20℃; for 18h; | 93.5% |
chloroacetyl chloride
7-Aminocephalosporanic acid
7-chloroacetamidocephalosporanic acid
Conditions | Yield |
---|---|
Stage #1: 7-Aminocephalosporanic acid With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane In dichloromethane at 20℃; for 1h; Stage #2: chloroacetyl chloride With copper(I) oxide at 0 - 20℃; for 1h; | 94% |
With sodium hydrogencarbonate In water; acetone for 3h; | 88.4% |
In ethyl acetate |
S(4),5,5-trimethyldithiohydantoin
7-Aminocephalosporanic acid
(6R,7R)-7-Amino-3-(4,4-dimethyl-5-methylsulfanyl-4H-imidazol-2-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Conditions | Yield |
---|---|
With chlorosulfonic acid In acetonitrile at 0℃; | 94% |
dichloroacethyl chloride
7-Aminocephalosporanic acid
(6R)-3-acetoxymethyl-7t-(2,2-dichloro-acetylamino)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 7-Aminocephalosporanic acid With sodium hydrogencarbonate In water at 0 - 35℃; Stage #2: dichloroacethyl chloride In water at 0 - 5℃; for 0.5h; Reagent/catalyst; | 93.6% |
Conditions | Yield |
---|---|
With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile at -5 - 0℃; for 1h; Temperature; | 93.1% |
Conditions | Yield |
---|---|
With aluminum oxide for 0.0333333h; microwave irradiation; | 93% |
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