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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--58909-56-1--(6R-trans)-7-amino-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid factory price Our company was built in 2009 with an ISO certifica

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Qingdao Beluga Import and Export Co., LTD

(6R-trans)-7-amino-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid CAS:58909-56-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological co

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

7-ACT

Cas:58909-56-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

7-Amino-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio]methyl]cephalosporanic acid

Cas:58909-56-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

7-Amino-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio]methyl]cephalosporanic acid

Cas:58909-56-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

7-Amino-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio]methyl]cephalosporanic acid

Cas:58909-56-1

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of service

7-Amino-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio]methyl]cephalosporanic acid

Cas:58909-56-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis:

Ceftriaxone Impurity E

Cas:58909-56-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

7-Amino-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio]methyl]cephalosporanic acid

Cas:58909-56-1

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

7-ACT

Cas:58909-56-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment .5) We can do different t

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

BOC Sciences

BOC Sciences is committed to supplying cost-effective products and services. We provide Ceftriaxone Impurity E. An intermediate in the synthesis of cephalosporin antibiotics, Ceftriaxone and Cefixime More information please visit: www.bocsci.com/c

Ceftriaxone Impurity E

Cas:58909-56-1

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Hubei Langyou International Trading Co., Ltd

7-Amino-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio]methyl]cephalosporanic acid Application:7-Amino-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio]methyl]cephalosporanic acid

Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

Ceftriaxone EP Impurity E CAS No.58909-56-1

Cas:58909-56-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:White to Off-White Solid Storage:Keep it in dry,shady and cool place Package:as your requirement Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by Sea

Hangzhou Fandachem Co.,Ltd

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-amino-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-,(6R,7R)- cas 58909-56-1Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place

Synthetic route

2-methyl-3-mercapto-5-oxo-6-hydroxy-2,5-dihydro-1,2,4-triazine
58909-39-0

2-methyl-3-mercapto-5-oxo-6-hydroxy-2,5-dihydro-1,2,4-triazine

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

Conditions
ConditionsYield
With boron trifluoride dimethyl carbonate complex; methanesulfonic acid at 10 - 12℃; for 0.383333h; Reagent/catalyst;95.1%
With boron trifluoride dimethyl carbonate complex; edetate disodium at 30℃; for 0.833333h; Time;90%
With boron trifluoride In acetonitrile at 10 - 30℃; for 0.5h;85.71%
7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

1,2,3,4-Tetrahydro-2-methyl-3-thioxo-1,2,4-triazine-5,6-dione

1,2,3,4-Tetrahydro-2-methyl-3-thioxo-1,2,4-triazine-5,6-dione

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

Conditions
ConditionsYield
With ethylenediaminetetraacetic acid; acetonitrile boron trifluoride complex at 30℃; for 0.333333h;88%
(6R,7R)-7-(4-Carboxy-butyrylamino)-3-(6-hydroxy-2-methyl-5-oxo-2,5-dihydro-[1,2,4]triazin-3-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-7-(4-Carboxy-butyrylamino)-3-(6-hydroxy-2-methyl-5-oxo-2,5-dihydro-[1,2,4]triazin-3-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

Conditions
ConditionsYield
With sodium hydroxide; glutaryl-7-aminocephalosporanic acid acylase In water at 25℃; pH=8.0; Enzyme kinetics; Enzymatic reaction;
C18H14N5O9PS2

C18H14N5O9PS2

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

Conditions
ConditionsYield
With ethylenediaminetetraacetic acid; sulphurous acid; sodium hydrogensulfite; triethylamine In ethanol; dichloromethane at 0 - 5℃; for 4h;95.7%
(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate
80756-85-0

(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

ceftriaxone disodium
74578-69-1

ceftriaxone disodium

Conditions
ConditionsYield
Stage #1: (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate; 7-aminoceftrizine With triethylamine In methanol at -2 - 3℃;
Stage #2: With sodium 2-ethylhexanoic acid In water; isopropyl alcohol at 26 - 30℃; for 2h; Product distribution / selectivity;
95.5%
With sodium metabisulfite; edetate disodium; triethylamine In ethanol; water at 1 - 3℃; for 3h; Time;91%
diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate

diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

ceftriaxone disodium
74578-69-1

ceftriaxone disodium

Conditions
ConditionsYield
Stage #1: 7-aminoceftrizine With N,O-bis-(trimethylsilyl)-acetamide In dichloromethane at 20℃; for 2h;
Stage #2: diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate In dichloromethane at 20℃; for 4h;
Stage #3: With sodium hydroxide In dichloromethane; water at 15 - 20℃; pH=7.5 - 7.8;
94.6%
Stage #1: 7-aminoceftrizine With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane In dichloromethane at 20℃; for 2h;
Stage #2: diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate In dichloromethane at 20℃; for 18h;
Stage #1: 7-aminoceftrizine With N,O-bis-(trimethylsilyl)-acetamide In DMF (N,N-dimethyl-formamide) at 20℃; for 2h;
Stage #2: diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate In DMF (N,N-dimethyl-formamide) at 20℃; for 4h;
Stage #3: With sodium hydroxide In DMF (N,N-dimethyl-formamide); water at 15 - 20℃; pH=7.5 - 7.8;
Stage #1: 7-aminoceftrizine With N,N'-bis(trimethylsilyl)urea In dichloromethane at 20℃; for 2h;
Stage #2: diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate In dichloromethane at 20℃; for 10h;
Stage #3: With sodium hydroxide In dichloromethane; water at 15 - 20℃; pH=7.5 - 7.8;
C14H24N3O5PS2

C14H24N3O5PS2

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

Conditions
ConditionsYield
With ethylenediaminetetraacetic acid; sulphurous acid; sodium hydrogensulfite; triethylamine In ethanol; dichloromethane at 0 - 5℃; for 4h;93.4%
C18H14N5O10PS

C18H14N5O10PS

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

Conditions
ConditionsYield
With ethylenediaminetetraacetic acid; sulphurous acid; sodium hydrogensulfite; triethylamine In ethanol; dichloromethane at 0 - 5℃; for 4h;93.3%
diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate

diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

Conditions
ConditionsYield
With ethylenediaminetetraacetic acid; sulphurous acid; sodium hydrogensulfite; triethylamine In ethanol; dichloromethane at 0 - 5℃; for 4h;92.8%
4-(diethylphosphoryl)-2-(2-amino-4-thiazolyl)-2-syn-(2-methoxyimino)acetate
179258-53-8

4-(diethylphosphoryl)-2-(2-amino-4-thiazolyl)-2-syn-(2-methoxyimino)acetate

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

Conditions
ConditionsYield
With ethylenediaminetetraacetic acid; sulphurous acid; sodium hydrogensulfite; triethylamine In ethanol; dichloromethane at 0 - 5℃; for 4h;91.7%
C20H20N3O5PS2

C20H20N3O5PS2

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

Conditions
ConditionsYield
With ethylenediaminetetraacetic acid; sulphurous acid; sodium hydrogensulfite; triethylamine In ethanol; dichloromethane at 0 - 5℃; for 4h;91.6%
C8H12N3O5PS2

C8H12N3O5PS2

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

Conditions
ConditionsYield
With ethylenediaminetetraacetic acid; sulphurous acid; sodium hydrogensulfite; triethylamine In ethanol; dichloromethane at 0 - 5℃; for 4h;91.2%
2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid
91868-79-0

2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

ceftriaxone disodium
74578-69-1

ceftriaxone disodium

Conditions
ConditionsYield
Stage #1: 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid With isopropyl chloroformate; triethylamine In dichloromethane; acetonitrile at -5 - 20℃; for 5h;
Stage #2: 7-aminoceftrizine In dichloromethane; acetonitrile at 20℃; for 6h;
89.18%
2-mercapto-benzothiazolyl-(Z)-2-(2-aminothiazol-4-yl)-2-methoxyimino acetate

2-mercapto-benzothiazolyl-(Z)-2-(2-aminothiazol-4-yl)-2-methoxyimino acetate

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

7-[[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyimino]acetamido]-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio]methyl]-3-cephem-4-carboxylic acid disodium salt

7-[[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyimino]acetamido]-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio]methyl]-3-cephem-4-carboxylic acid disodium salt

Conditions
ConditionsYield
Stage #1: 2-mercapto-benzothiazolyl-(Z)-2-(2-aminothiazol-4-yl)-2-methoxyimino acetate; 7-aminoceftrizine With triethylamine In tetrahydrofuran; water at 0 - 5℃;
Stage #2: With sodium 2-ethylhexanoic acid
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

1,1,1,3,3,3-hexamethyl-disilazane
999-97-3

1,1,1,3,3,3-hexamethyl-disilazane

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

C18H29N5O5S2Si2
847835-82-9

C18H29N5O5S2Si2

Conditions
ConditionsYield
In dichloromethane for 8h; Heating / reflux;
In dichloromethane at 20℃; for 8h; Product distribution / selectivity; Heating / reflux;
N,O-bis-(trimethylsilyl)-acetamide
10416-59-8

N,O-bis-(trimethylsilyl)-acetamide

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

C18H29N5O5S2Si2
847835-82-9

C18H29N5O5S2Si2

Conditions
ConditionsYield
In dichloromethane at 25 - 30℃; for 2h;
N,O-bis-(trimethylsilyl)-acetamide
10416-59-8

N,O-bis-(trimethylsilyl)-acetamide

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

(7R,8R)-7-(trimethylsilylamino)-3-[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thiomethyl]-3-cephem-4-carboxylic acid

(7R,8R)-7-(trimethylsilylamino)-3-[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thiomethyl]-3-cephem-4-carboxylic acid

Conditions
ConditionsYield
In dichloromethane at 20℃; for 2 - 3h;
2-amino-4-thiazoleglyoxylic acid (Z)-O-[[(3,4-dihydroxyphenyl)sulphonyl]methyl] oxime
121170-86-3

2-amino-4-thiazoleglyoxylic acid (Z)-O-[[(3,4-dihydroxyphenyl)sulphonyl]methyl] oxime

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

(6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-[[[(3,4-dihydroxyphenyl)sulphonyl]methoxy]imino]acetamido]-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium salt

(6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-[[[(3,4-dihydroxyphenyl)sulphonyl]methoxy]imino]acetamido]-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium salt

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

7-bromoacetamido-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio)methyl)cephalosporanic acid

7-bromoacetamido-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio)methyl)cephalosporanic acid

Conditions
ConditionsYield
Stage #1: 2-Bromoacetyl bromide; 7-aminoceftrizine With sodium hydrogencarbonate; triethylamine In water; toluene for 2h;
Stage #2: In water pH=3; Product distribution / selectivity; Acidic conditions;
Stage #1: 2-Bromoacetyl bromide; 7-aminoceftrizine With triethylamine In water; ethyl acetate at 0 - 10℃;
Stage #2: In water; ethyl acetate pH=3; Product distribution / selectivity; Acidic conditions;
Stage #1: 2-Bromoacetyl bromide; 7-aminoceftrizine With sodium hydrogencarbonate; triethylamine In water; acetone for 1h;
Stage #2: With hydrogenchloride In water; acetone pH=3; Product distribution / selectivity;
Stage #1: 2-Bromoacetyl bromide; 7-aminoceftrizine With sodium hydrogencarbonate; triethylamine In water; propiononitrile at 0 - 10℃;
Stage #2: In water; propiononitrile pH=3; Product distribution / selectivity; Acidic conditions;
Stage #1: 2-Bromoacetyl bromide; 7-aminoceftrizine With triethylamine In dichloromethane; water for 2h;
Stage #2: With hydrogenchloride In water pH=3; Product distribution / selectivity;
4-chloro-2(Z)-metoxyimino-3-oxobutyric acid chloride
117683-58-6

4-chloro-2(Z)-metoxyimino-3-oxobutyric acid chloride

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

C17H17ClN6O8S2
614751-38-1

C17H17ClN6O8S2

Conditions
ConditionsYield
Stage #1: 7-aminoceftrizine With N,O-bis-(trimethylsilyl)-acetamide In dichloromethane at 35 - 40℃; for 1.5h;
Stage #2: 4-chloro-2(Z)-metoxyimino-3-oxobutyric acid chloride In dichloromethane at -10℃; for 0.25h;
Stage #3: With sodium carbonate In dichloromethane; water at 4 - 7℃; for 1h; pH=5 - 6;
Stage #1: 7-aminoceftrizine With N,N'-bis(trimethylsilyl)urea In dichloromethane at 35 - 40℃; for 5h;
Stage #2: 4-chloro-2(Z)-metoxyimino-3-oxobutyric acid chloride In dichloromethane at -15℃; for 0.25h;
Stage #3: With sodium carbonate In dichloromethane; water at 4 - 7℃; pH=5.8 - 6;
C18H16N3O5PS2

C18H16N3O5PS2

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

Conditions
ConditionsYield
With ethylenediaminetetraacetic acid; sulphurous acid; sodium hydrogensulfite; triethylamine In ethanol; dichloromethane at 0 - 5℃; for 4h;
(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate
80756-85-0

(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

Conditions
ConditionsYield
With ethylenediaminetetraacetic acid; sulphurous acid; sodium hydrogensulfite; triethylamine In ethanol; dichloromethane at 0 - 5℃; for 4h;
2-(2-amino-1,3-thiazol-4-yl)-1-(1,3-benzothiazol-2-ylsulfanyl)-2-(methoxyimino)ethan-1-one
94088-75-2

2-(2-amino-1,3-thiazol-4-yl)-1-(1,3-benzothiazol-2-ylsulfanyl)-2-(methoxyimino)ethan-1-one

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

ceftriaxone

ceftriaxone

Conditions
ConditionsYield
With N,N,N',N'-tetramethylguanidine In ethanol; dichloromethane at -10 - -5℃; for 4h; Reagent/catalyst;
7-aminoceftrizine
58909-56-1

7-aminoceftrizine

7-(α-((N,N'-diisopropylamidino)thio)acetylamino)-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio)methyl) cephalosporanic acid

7-(α-((N,N'-diisopropylamidino)thio)acetylamino)-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio)methyl) cephalosporanic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / water; ethyl acetate / 0 - 10 °C
1.2: pH 3 / Acidic conditions
2.1: diethylamine / dichloromethane; acetone / pH 5.0 - 7.5 / Heating / reflux
View Scheme
2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid
91868-79-0

2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid

7-aminoceftrizine
58909-56-1

7-aminoceftrizine

ceftriaxone

ceftriaxone

Conditions
ConditionsYield
With sulfuryl dichloride; pyrographite; sodium hydrogensulfite; N,N,N',N'-tetramethylguanidine In dichloromethane; water; N,N-dimethyl-formamide at 20℃; for 0.5h;

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