As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:586-76-5
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:586-76-5
Min.Order:1 Kilogram
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Type:Manufacturers
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:586-76-5
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Manufacturers
inquiryUnique advantages of 4-Bromobenzoic acid Cas 586-76-5 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to light red crystalline powder Storage:Cool dry place Packag
Cas:586-76-5
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:586-76-5
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:586-76-5
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryTIANFUCHEM--586-76-5--4-Bromobenzoic acid factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business rel
Cas:586-76-5
Min.Order:1 Metric Ton
FOB Price: $2000.0
Type:Lab/Research institutions
inquiryOur advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity ≥99% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package c
Cas:586-76-5
Min.Order:1 Kilogram
FOB Price: $5.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:586-76-5
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
Cas:586-76-5
Min.Order:1 Kilogram
FOB Price: $10.0 / 20.0
Type:Trading Company
inquiryAbout Product Details
Cas:586-76-5
Min.Order:1 Kilogram
FOB Price: $3.0 / 5.0
Type:Lab/Research institutions
inquiryProduct Name: 4-Bromobenzoic acid Synonyms: 4-bromo-benzoicaci;Benzoic acid, p-bromo-;Benzoicacid,4-bromo-;p-bromobenzenecarboxylicacid;p-bromo-benzoicaci;p-Carboxybromobenzene;4-Bromobenzoic aicd;4-Brom-be
1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea
Cas:586-76-5
Min.Order:1 Gram
FOB Price: $2.0
Type:Lab/Research institutions
inquiryAppearance:White to beige to pink-brownish Storage:Sealed in dry,Room Temperature Package:25kg/Barrel Application:An important fine chemical used as an analytical reagent and as an intermediate in organic synthesis. It is used in organic synthesis a
Cas:586-76-5
Min.Order:50 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:586-76-5
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:586-76-5
Min.Order:1 Kilogram
FOB Price: $82.4 / 86.2
Type:Trading Company
inquiry4-Bromobenzoic acid CAS:586-76-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interme
Cas:586-76-5
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:586-76-5
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Cas:586-76-5
Min.Order:1 Kilogram
FOB Price: $40.0 / 50.0
Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Appearance:white or yellowish white flaky crystal Storage:Keep the sun from direct sunlight ;prevention against high temperature Package:As customer request Application:Used for research and industrial manufacture. Transportatio
Cas:586-76-5
Min.Order:100 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:586-76-5
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:586-76-5
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:586-76-5
Min.Order:100 Gram
FOB Price: $100.0 / 2000.0
Type:Lab/Research institutions
inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Cas:586-76-5
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryConditions | Yield |
---|---|
With sodium chromate(VI); sulfuric acid | 100% |
With tert.-butylhydroperoxide; water at 20℃; for 14h; Inert atmosphere; | 99% |
With sulfuric acid; ozone; acetic acid; manganese(II) acetate at 16℃; for 1.25h; Product distribution / selectivity; | 98% |
Conditions | Yield |
---|---|
With aluminum oxide; potassium hydroxide In toluene for 22h; Product distribution; Ambient temperature; | 100% |
Stage #1: 4-methoxycarbonylphenyl bromide With sodium hydroxide In tetrahydrofuran; water at 20℃; Stage #2: With hydrogenchloride In water at 0℃; pH=2; | 100% |
With iodine; aluminium In acetonitrile at 80℃; for 18h; | 99% |
1-isocyanato-1-phenyl-2,2,2-trifluoroethyl 4-bromobenzoate
p-Chlorothiophenol
A
4-Bromobenzoic acid
B
1-phenyl-1-(4-chlorophenylthio)-2,2,2-trifluoroethyl isocyanate
Conditions | Yield |
---|---|
In benzene 1.) 20 deg C, 12 h, 2.) reflux, 3 h; | A 100% B 87% |
Conditions | Yield |
---|---|
With amphiphilic resin-supported phosphine-palladium; water; potassium carbonate at 25℃; under 760 Torr; for 12h; hydroxycarbonylation; | 100% |
With water; potassium carbonate In acetonitrile at 100℃; under 3750.38 Torr; for 0.0161111h; | 93% |
With water; palladium diacetate; potassium carbonate at 20℃; under 760.051 Torr; for 6h; | 91% |
para-bromoacetophenone
phenylboronic acid
A
biphenyl-4-acetaldehyde
B
4-Bromobenzoic acid
C
biphenyl-4-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: para-bromoacetophenone; phenylboronic acid; immobilized 4-bromobenzoic acid With potassium carbonate In water; N,N-dimethyl-formamide Stage #2: With potassium hydroxide In ethanol; water | A 100% B 19% C 81% |
Conditions | Yield |
---|---|
With magnesium In tetrahydrofuran at -78℃; for 0.5h; | 99% |
Conditions | Yield |
---|---|
With tert.-butylhydroperoxide; di-tert-butyl peroxide; silica-supported selenamide In water; tert-butyl alcohol at 75℃; for 7h; | 99% |
With 4H3N*4H(1+)*CuMo6O18(OH)6(4-); water; oxygen; sodium carbonate at 50℃; under 760.051 Torr; for 12h; | 99% |
With sheep hemoglobin; oxygen In water at 20℃; under 760.051 Torr; for 150h; pH=7.0; Catalytic behavior; Darkness; Green chemistry; Enzymatic reaction; chemoselective reaction; | 99% |
bis-(4-bromo-benzylidene)-hydrazine
4-Bromobenzoic acid
Conditions | Yield |
---|---|
With poly(diselanediyl-1,2-phenylene); dihydrogen peroxide In tetrahydrofuran for 20h; Heating; | 99% |
With [bis(acetoxy)iodo]benzene In tetrahydrofuran at 20℃; for 4h; Green chemistry; | 80% |
p-bromobenzaldehyde tosylhydrazone
4-Bromobenzoic acid
Conditions | Yield |
---|---|
With silica-supported selenamide; dihydrogen peroxide In tetrahydrofuran at 55℃; for 42h; | 99% |
With poly(diselanediyl-1,2-phenylene); dihydrogen peroxide In tetrahydrofuran for 10h; Heating; | 90% |
carbon dioxide
2-(4-bromophenyl)-5,5-dimethyl-1,3,2-dioxaborinane
4-Bromobenzoic acid
Conditions | Yield |
---|---|
With potassium tert-butylate; copper(l) chloride; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In tetrahydrofuran at 70℃; under 760.051 Torr; for 24h; | 99% |
With (1,3-bis(2,6-diisopropyl-4-(morpholinomethyl)phenyl)imidazolidin-2-ylidene)copper(I) bromide; potassium tert-butylate In tetrahydrofuran under 760.051 Torr; for 24h; Inert atmosphere; Schlenk technique; Reflux; Green chemistry; | 94% |
Stage #1: carbon dioxide; 2-(4-bromophenyl)-5,5-dimethyl-1,3,2-dioxaborinane With copper(l) iodide; 5,5-bis(4,5-dihydrooxazol-2-yl)nonane; cesium fluoride In N,N-dimethyl-formamide at 90℃; under 760.051 Torr; for 10h; Stage #2: With hydrogenchloride; water In N,N-dimethyl-formamide | 86% |
Stage #1: carbon dioxide; 2-(4-bromophenyl)-5,5-dimethyl-1,3,2-dioxaborinane With potassium tert-butylate; silver(I) acetate; triphenylphosphine In 1,4-dioxane at 100℃; under 15201 Torr; for 8h; Inert atmosphere; Autoclave; Stage #2: With hydrogenchloride In tetrahydrofuran; water Inert atmosphere; | 71% |
Conditions | Yield |
---|---|
With silica-supported Jones reagent In dichloromethane for 0.035h; | 98.3% |
With C30H24AgBr4N8(1+)*AgBr2(1-); potassium hydroxide In 1,2-dimethoxyethane at 60℃; for 24h; Molecular sieve; Schlenk technique; | 98% |
With diethylene glycol dimethyl ether at 70℃; for 0.5h; Sonication; | 98% |
4-bromobenzaldehyde oxime
4-Bromobenzoic acid
Conditions | Yield |
---|---|
With poly(diselanediyl-1,2-phenylene); dihydrogen peroxide In tetrahydrofuran for 28h; Heating; | 98% |
With silica-supported selenamide; dihydrogen peroxide In tetrahydrofuran at 55℃; for 37h; | 96% |
With [hydroxy(tosyloxy)iodo]benzene; water In dimethyl sulfoxide at 20℃; for 24h; | 89% |
Conditions | Yield |
---|---|
With Oxone In water; acetonitrile for 15h; Reflux; | 98% |
With sodium periodate; sulfuric acid In water at 95℃; for 12h; | 81% |
With tert.-butylhydroperoxide at 100℃; for 5h; | 75% |
With tert.-butylhydroperoxide In water at 80℃; for 12h; Green chemistry; |
Conditions | Yield |
---|---|
Stage #1: carbon dioxide; (4-bromophenyl)zinc iodide With lithium chloride In N,N-dimethyl-formamide at 50℃; under 760.051 Torr; for 48h; Stage #2: With hydrogenchloride; water In N,N-dimethyl-formamide | 98% |
Conditions | Yield |
---|---|
With 40% potassium fluoride/alumina for 0.0666667h; Microwave irradiation; Neat (no solvent); | A 97% B 91% |
Conditions | Yield |
---|---|
Stage #1: 1-bromo-4-ethenyl-benzene With tert.-butylhydroperoxide; iron(III) chloride hexahydrate; sodium hydroxide In water at 80℃; for 10h; Stage #2: With hydrogenchloride In water at 20℃; | 96% |
With Oxone In water; acetonitrile for 12h; Reflux; | 90% |
With sodium periodate; 2C16H13N2O10Ru2(1-)*Ca(2+) In water at 45℃; for 16h; Green chemistry; | 90% |
1-(4-bromophenyl)ethane-1,2-diol
4-Bromobenzoic acid
Conditions | Yield |
---|---|
With tert.-butylhydroperoxide; potassium tert-butylate In water at 80℃; for 8h; | 96% |
Conditions | Yield |
---|---|
Stage #1: para-bromoacetophenone With tert.-butylhydroperoxide; sodium hydroxide; tungsten(VI) oxide In water at 80℃; for 8h; Stage #2: With hydrogenchloride In water | 95% |
Stage #1: para-bromoacetophenone With iodine; dimethyl sulfoxide In chlorobenzene at 130℃; for 3h; Stage #2: With tert.-butylhydroperoxide In chlorobenzene at 20 - 130℃; for 5h; | 89% |
With Oxone; trifluoroacetic acid In 1,4-dioxane for 10h; Reflux; Green chemistry; | 85% |
Conditions | Yield |
---|---|
With tert.-butylhydroperoxide; copper(ll) bromide In acetic anhydride | A 3% B 95% |
Conditions | Yield |
---|---|
With potassium hydroxide; oxygen In 1,2-dimethoxyethane at 70℃; for 3h; | 95% |
Multi-step reaction with 3 steps 1: alcohol / Sonnenlicht 2: acetyl chloride / 100 °C 3: alcoholic KOH-solution View Scheme |
1-(4-bromophenyl)-2,2,2-trichloroethan-1-ol
4-Bromobenzoic acid
Conditions | Yield |
---|---|
With sodium hydroxide; dihydrogen peroxide In methanol for 10h; | 95% |
Conditions | Yield |
---|---|
With acetic acid In titanium | A n/a B 95% |
Conditions | Yield |
---|---|
With 1-butyl-3-methylimidazolium hydrogen sulfate; water at 60 - 65℃; for 2.2h; Green chemistry; | 95% |
(Z)-3-chloro-3-(4-bromophenyl)acrylic acid
4-Bromobenzoic acid
Conditions | Yield |
---|---|
With trichlorophosphate at 80℃; for 0.5h; | 94% |
Conditions | Yield |
---|---|
With Amberlyst A-26 (OH-); dihydrogen peroxide In 1,4-dioxane at 20℃; for 10h; | 93% |
With Oxone In water; acetonitrile for 24h; Reflux; | 86% |
1,4-bromoiodobenzene
diphenylmethylsilanecarboxylic acid
4-Bromobenzoic acid
Conditions | Yield |
---|---|
With potassium trimethylsilonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium(0) In toluene at 40℃; for 0.333333h; | 93% |
methanol
4-bromo-benzaldehyde
A
4-Bromobenzoic acid
B
4-methoxycarbonylphenyl bromide
Conditions | Yield |
---|---|
With C12H22N6(2+)*2C2F6NO4S2(1-); 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 55℃; for 16h; Reagent/catalyst; Molecular sieve; | A 7% B 93% |
With dihydrogen peroxide; calcium chloride at 65℃; for 48h; Reagent/catalyst; | A n/a B 81% |
With 3,3'-dimethyl-1,1'-(hexane-1,6-diyl)diimidazolium glutarate; 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 55℃; for 16h; Reagent/catalyst; Temperature; Molecular sieve; | A 11% B 78% |
With dihydrogen peroxide at 20℃; for 8h; |
Conditions | Yield |
---|---|
With aluminium trichloride; dimethylsulfide for 16h; Ambient temperature; | 92.5% |
Stage #1: Ethyl 4-bromobenzoate With iron(III) chloride In tetrachloromethane at 85℃; for 24h; Inert atmosphere; Stage #2: With hydrogenchloride; water In tetrachloromethane Inert atmosphere; | 92% |
Stage #1: Ethyl 4-bromobenzoate With sodium hydroxide In water at 20℃; Stage #2: With hydrogenchloride In water |
Conditions | Yield |
---|---|
Stage #1: 4-bromo-benzaldehyde With potassium hydroxide for 0.0833333h; Cannizzaro Reaction; Milling; Inert atmosphere; Sealed tube; Green chemistry; Stage #2: With hydrogenchloride In water Green chemistry; | A 92% B 92% |
With sodium hydroxide In water at 15℃; for 3h; Cannizzaro Reaction; | A 90% B n/a |
With [(hydrotris(3,5-diphenylpyrazole-1-yl)borate)-FeII(benzilate)]; oxygen In benzene at 20℃; Inert atmosphere; | A 85% B 40% |
Conditions | Yield |
---|---|
Stage #1: 4-bromo-1-ethynylbenzene With tert.-butylhydroperoxide; iron(III) chloride hexahydrate; sodium hydroxide In water at 80℃; for 10h; Stage #2: With hydrogenchloride In water at 20℃; | 92% |
With Oxone; trifluoroacetic acid In 1,4-dioxane for 10h; Reflux; Green chemistry; | 89% |
With methyl 3,5-bis((1H-1,2,4-triazol-1-yl)methyl)benzoate; oxygen; sodium acetate; nickel dibromide at 120℃; under 760.051 Torr; for 48h; | 79% |
Conditions | Yield |
---|---|
With pyridine; sodium hydrogencarbonate; 4-chloro-3-nitro-chromen-2-one In N,N-dimethyl-formamide at 18 - 60℃; for 0.3h; | 100% |
With potassium carbonate In dichloromethane at 20℃; for 0.416667h; | 80% |
Stage #1: 4-Bromobenzoic acid With Bromotrichloromethane; triphenylphosphine In dichloromethane for 5h; Reflux; Stage #2: With triethylamine In dichloromethane for 8h; Reflux; | 79% |
Conditions | Yield |
---|---|
With thionyl chloride In dichloromethane for 18h; Heating; | 100% |
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane for 1h; Product distribution / selectivity; | 100% |
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h; Reflux; | 100% |
4-Bromobenzoic acid
2-Methylphenylboronic acid
4-(2-methylphenyl)benzoic acid
Conditions | Yield |
---|---|
With disodium hydrogenphosphate; disodium bis(2-aminopyrimidine-4,6-diolate)palladium acetate In water at 50 - 120℃; for 0.166667h; Microwave irradiation; | 100% |
With disodium hydrogenphosphate; Pd(OAc)2(2-amino-4,6-dihydroxypyrimidine disodium salt)2 In water at 120℃; for 0.166667h; Suzuki-Miyaura coupling; Microwave irradiation; | 99% |
With 4C3H6N6*Pd(2+)*2C2H3O2(1-); sodium carbonate In water at 80℃; for 2h; Suzuki-Miyaura Coupling; Green chemistry; | 97% |
2,2-dimethyl-propanol-1
4-Bromobenzoic acid
4-Bromo-benzoic acid 2,2-dimethyl-propyl ester
Conditions | Yield |
---|---|
With sulfuric acid In toluene | 100% |
Conditions | Yield |
---|---|
With sodium carbonate; Pd-complex on fluorous reversed silica gel In water at 80℃; for 16h; Suzuki reaction; | 100% |
With potassium carbonate; carbapalladacycle complex*periodic mesoporous organosilica for 24h; Suzuki coupling; Heating; | 100% |
With sodium phosphate; palladium on activated charcoal In water; isopropyl alcohol at 20℃; for 3.5h; Suzuki-Miyaura coupling reaction; | 100% |
Conditions | Yield |
---|---|
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,4-dioxane for 2h; Heating; | 100% |
(R)-4-hydroxymethyl-2-phenyl-4,5-dihydrooxazol-4-ylmethyl acetate
4-Bromobenzoic acid
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 1h; | 100% |
4-Bromobenzoic acid
m-tolylboronic acid
3'‐methyl‐(1,1'‐biphenyl)‐4‐carboxylic acid
Conditions | Yield |
---|---|
With disodium hydrogenphosphate; disodium bis(2-aminopyrimidine-4,6-diolate)palladium acetate In water at 50 - 120℃; for 0.166667h; Microwave irradiation; | 100% |
With 4C3H6N6*Pd(2+)*2C2H3O2(1-); sodium carbonate In water at 80℃; for 2h; Suzuki-Miyaura Coupling; Green chemistry; | 99% |
Stage #1: 4-Bromobenzoic acid; m-tolylboronic acid; palladium diacetate In water at 20℃; for 0.0833333h; Suzuki-Miyaura coupling; Stage #2: With potassium hydroxide In water at 20 - 75℃; for 2h; | 90% |
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 105℃; for 5h; Suzuki Coupling; Inert atmosphere; |
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 20h; | 100% |
Stage #1: 4-Bromobenzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #2: morpholine In N,N-dimethyl-formamide at 20℃; for 18h; | 99% |
Stage #1: 4-Bromobenzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h; Stage #2: morpholine With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2h; | |
Stage #1: 4-Bromobenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 25℃; for 1h; Stage #2: morpholine With triethylamine In dichloromethane at 0 - 25℃; for 16h; |
4-Bromobenzoic acid
tert–butyl (2–aminophenyl)carbamate
N-(2-t-butoxycarbonylaminophenyl)-4-bromobenzamide
Conditions | Yield |
---|---|
With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In N,N-dimethyl-formamide at 20℃; for 20h; | 100% |
Conditions | Yield |
---|---|
With sulfuric acid In methanol for 16h; Reflux; | 100% |
With sulfuric acid In methanol | 97% |
With sulfuric acid; sodium carbonate | 97% |
Conditions | Yield |
---|---|
Stage #1: 4-Bromobenzoic acid With 4-(Methylamino)pyridine; diisopropyl-carbodiimide In dichloromethane at 20℃; Stage #2: With hydroxylamine In dichloromethane; water at 20℃; Further stages.; | 100% |
Stage #1: 4-Bromobenzoic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 23℃; for 1h; Inert atmosphere; Stage #2: In tetrahydrofuran at 23℃; for 12h; Inert atmosphere; | 85% |
Stage #1: 4-Bromobenzoic acid With 4-methyl-morpholine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In ethyl acetate; acetonitrile at 0℃; for 0.25h; Stage #2: With hydroxylamine hydrochloride In ethyl acetate; acetonitrile Ultrasonication; | 83% |
Conditions | Yield |
---|---|
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 20℃; for 36h; | 100% |
N1-tert-butyl-5-((tert-butyldimethylsilyloxy)methyl)benzene-1,2-disulfonamide
4-Bromobenzoic acid
4-bromo-N-(4-((tert-butyldimethylsilyloxy)methyl)-2-(N-tert-butylsulfamoyl)phenylsulfonyl)benzamide
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; | 100% |
4-Bromobenzoic acid
4-bromo-N-(4-((tert-butyldimethylsilyloxy)methyl)-2-(N-tert-butylsulfamoyl)phenylsulfonyl)benzamide
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; | 100% |
4-Bromobenzoic acid
1-t-Butoxycarbonylpiperazine
4-(4-bromobenzoyl)piperazine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 18h; | 100% |
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 15h; | 94% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h; | |
Stage #1: 4-Bromobenzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: 1-t-Butoxycarbonylpiperazine In N,N-dimethyl-formamide at 20℃; |
4-Bromobenzoic acid
tert-butyl 2-(aminomethyl)-pyrrolidine-1-carboxylate
2-(4-bromobenzoylaminomethyl)pyrrolidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With 4-methyl-morpholine; HATU In N,N-dimethyl-formamide for 3h; | 100% |
Conditions | Yield |
---|---|
With 1,1'-carbonyldiimidazole In tetrahydrofuran at 60℃; Inert atmosphere; | 100% |
With 1-ethyl-3-(3-dimethyl-aminopropyl) carbodiimide; benzotriazol-1-ol; triethylamine In dichloromethane at 20℃; | 83% |
Stage #1: 4-Bromobenzoic acid With chloroformic acid ethyl ester; triethylamine In dichloromethane at 0℃; for 0.5h; Inert atmosphere; Stage #2: 1-amino-2-propene In dichloromethane Inert atmosphere; | 38% |
Stage #1: 4-Bromobenzoic acid With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 0.166667h; Inert atmosphere; Stage #2: 1-amino-2-propene In dichloromethane at 0 - 20℃; Inert atmosphere; |
4-aminotetrahydropyran
4-Bromobenzoic acid
4-bromo-N-(tetrahydropyran-4-yl)benzamide
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 16h; Cooling with ice; | 100% |
4-Bromobenzoic acid
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 48h; | 100% |
4-Bromobenzoic acid
N-BOC-1,2-diaminoethane
tert-butyl (2-(4-bromobenzamido)ethyl)carbamate
Conditions | Yield |
---|---|
With oxalyl dichloride In tetrahydrofuran; N,N-dimethyl-formamide at 0 - 20℃; for 3h; | 100% |
Conditions | Yield |
---|---|
With sulfuric acid Heating; | 99.6% |
With sulfuric acid for 12h; Heating; | 98% |
With sulfuric acid for 4h; Fischer esterification; Reflux; | 98% |
Conditions | Yield |
---|---|
With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine In 1,2-dichloro-ethane at 20℃; for 5h; | 99% |
With sulfuric acid Reflux; | 98% |
With sulfuric acid for 3h; Heating; | 97% |
Conditions | Yield |
---|---|
With copper(I) oxide; tetra(n-butyl)ammonium hydroxide; 1,10-phenanthroline-4,7-diol In water at 110℃; for 24h; Inert atmosphere; Schlenk technique; Sealed tube; Green chemistry; | 99% |
Stage #1: 4-Bromobenzoic acid With copper(l) iodide; cesium hydroxide; 5-bromo-2-(1H-imidazol-2-yl)pyridine In water; dimethyl sulfoxide at 100℃; for 36h; Inert atmosphere; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide pH=1 - 2; Inert atmosphere; | 91% |
With copper(I) oxide; 2-pyridinealdoxime; cesium hydroxide; tetrabutylammomium bromide In water at 110℃; for 48h; Inert atmosphere; | 87% |
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