Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:60456-26-0
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiry(R)-Glycidyl butyrate Manufacturer Factory CAS 60456-26-0 (R)-Glycidyl butyrate Manufacturer High quality Best price In stock factory CAS 60456-26-0 (R)-Glycidyl butyrate COA TDS price MSDS Name (R)-Glycidyl butyrate Synonyms Oxi
Cas:60456-26-0
Min.Order:5 Kiloliter
FOB Price: $3.5 / 5.0
Type:Manufacturers
inquiryProduct Name: (R)-Glycidyl butyrate Synonyms: Butanoic acid,(2R)-2-oxiranylmethyl ester;(2R)-(-)-GLYCIDYL BUTYRATE;BUTYRIC ACID (R)-GLYCIDYL ESTER;(R)-(-)-GLYCIDYL BUTYRATE;(R)-GLYCIDYL BUTYRATE;(R)-OXIRANE-2-METHANOL BUTYRATE;R(-)-OXIRANE-2-METHA
Cas:60456-26-0
Min.Order:1 Kilogram
FOB Price: $300.0
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:60456-26-0
Min.Order:1 Kilogram
FOB Price: $3.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:60456-26-0
Min.Order:10 Gram
FOB Price: $146.0 / 176.0
Type:Trading Company
inquiry1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;
1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:60456-26-0
Min.Order:1 Kilogram
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inquiry(R)-Glycidyl butyrate CAS:60456-26-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic int
Cas:60456-26-0
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:60456-26-0
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryHebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several
Cas:60456-26-0
Min.Order:25 Gram
FOB Price: $90.0 / 100.0
Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:60456-26-0
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:60456-26-0
Min.Order:4 Kilogram
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Type:Lab/Research institutions
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:60456-26-0
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Type:Other
inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:60456-26-0
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:60456-26-0
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiry(R)-Glycidyl butyrateAppearance:Pls see the Details Storage:Keep away of light, hot, water, Store in dry, dark and ventilated place Package:according to customers' requirements Application:Steroids, Cosmetics Ingredients, APIs, Intermediates, OLED&Ba
Superior quality, moderate price & quick delivery. Appearance:colourless liquid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediat
Cas:60456-26-0
Min.Order:1 Gram
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Type:Trading Company
inquiryProduct name: (R)-(-)-Glycidyl Butyrate CAS No.:60456-26-0 Molecule Formula:C7H12O3 Molecule Weight:144.16 Purity: 99% Package: 25kg/drum Description:Colorless or light yellow liquid Manufacture Standards:Enterprise Standard TEST
Cas:60456-26-0
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp
Cas:60456-26-0
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:60456-26-0
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:60456-26-0
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:60456-26-0
Min.Order:1 Metric Ton
FOB Price: $1.5
Type:Trading Company
inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
Product Name: (R)-Glycidyl butyrate Synonyms: (2R)-(-)-GLYCIDYL BUTYRATE;BUTYRIC ACID (R)-GLYCIDYL ESTER;(R)-(-)-GLYCIDYL BUTYRATE;(R)-GLYCIDYL BUTYR…Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:aluminum foil bag,carton
High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
butyric acid-3-chloro-(S)-2-hydroxy-propyl ester
(R)-glycidyl butyrate
Conditions | Yield |
---|---|
With sodium hydroxide for 12h; Reflux; | 90% |
With potassium phosphate; [(S,S)-(salen)Co(II)]2*Al(NO3)3 In various solvent(s) at 20℃; | 40% |
With potassium tert-butylate In 1,2-dichloro-ethane at 0℃; for 1h; | 72.0 %Chromat. |
Conditions | Yield |
---|---|
With calcium oxide In 2-methyltetrahydrofuran at 20℃; for 6h; Green chemistry; chemoselective reaction; | 89% |
(+/-)-glycidyl butyrate
A
1-sn-monobutyroylglycerol
B
(R)-glycidyl butyrate
C
(S)-2,3-dihydroxypropyl butyrate
Conditions | Yield |
---|---|
With [(S,S)-N,N’-bis(3,5-di-tertbutylsalicylidene)-1,2-cyclohexanediaminato(2-)]cobalt(II); air; acetic acid In tetrahydrofuran at 0 - 20℃; | A n/a B 46% C n/a |
(+/-)-glycidyl butyrate
A
(R)-glycidyl butyrate
B
(S)-2,3-dihydroxypropyl butyrate
Conditions | Yield |
---|---|
With [(S,S)-N,N’-bis(3,5-di-tertbutylsalicylidene)-1,2-cyclohexanediaminato(2-)]cobalt(II); air; acetic acid In tetrahydrofuran at 0 - 20℃; | A 46% B n/a |
(+/-)-glycidyl butyrate
A
(R)-glycidyl butyrate
B
(R)-oxiranemethanol
Conditions | Yield |
---|---|
With sodium phosphate buffer; 25 kDa lipase-like enzyme immobilized on DEAE-Sepharose In 1,4-dioxane; water at 25℃; for 10h; pH=7.00; | A n/a B 45% |
With thermomyces lanuginosa In 1,4-dioxane; aq. phosphate buffer at 30℃; for 2h; pH=7; Temperature; Resolution of racemate; Enzymatic reaction; | A n/a B n/a |
(+/-)-glycidyl butyrate
A
butyric acid-3-chloro-(S)-2-hydroxy-propyl ester
B
butyric acid-3-chloro-(R)-2-hydroxy-propyl ester
C
(R)-glycidyl butyrate
D
(S)-glycidyl butyrate
Conditions | Yield |
---|---|
With hydrogenchloride; (R,R)-[Co(salen)]2*GaCl3 In diethyl ether at 0 - 4℃; for 4h; | A 45% B n/a C n/a D 43% |
(+/-)-glycidyl butyrate
A
(R)-glycidyl butyrate
B
(S)-2,3-dihydroxypropyl butyrate
C
(S)-glycidyl butyrate
Conditions | Yield |
---|---|
With (acetao)(aqua)(S,S)-N,N′-bis(3,5-di-tert-butylsalicylidene-1,2-cyclohexanediamino)-cobalt(III); water In tetrahydrofuran at 0℃; for 12h; Jacobsen rearrangement; optical yield given as %ee; | A 40% B n/a C n/a |
(+/-)-glycidyl butyrate
A
(R)-glycidyl butyrate
B
(R)-oxiranemethanol
C
(S)-oxiranemethanol
Conditions | Yield |
---|---|
With Rhizopus oryzae lipase on dextran sulfate coated Sepabeads In water at 25℃; pH=7; Enzymatic reaction; Title compound not separated from byproducts; |
Conditions | Yield |
---|---|
With triethylamine; dmap In dichloromethane at 0 - 20℃; for 1h; Product distribution / selectivity; | n/a |
Conditions | Yield |
---|---|
With Rhizopus oryzae lipase/polystyrene fibers at 35℃; for 1h; Kinetics; |
(+/-)-glycidyl butyrate
A
1-sn-monobutyroylglycerol
B
(R)-glycidyl butyrate
C
(S)-glycidyl butyrate
Conditions | Yield |
---|---|
With 4CF3O3S(1-)*Co(3+)*Y(3+)*C36H52N2O2(2-); water In neat (no solvent) at 20℃; for 12h; Overall yield = 19 %; enantioselective reaction; | A n/a B n/a C n/a |
4-(methylthio)phenyl isocyanate
(R)-glycidyl butyrate
(R)-<3-<4-(methylthio)phenyl>-2-oxo-5-oxazolidinyl>methyl butyrate
Conditions | Yield |
---|---|
With Tributylphosphine oxide; lithium bromide In xylene for 2h; Heating; | 100% |
(R)-glycidyl butyrate
2,6-diaminopurine
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide at 100℃; for 4h; | 100% |
(R)-glycidyl butyrate
(R)-3-(3-Fluoro-4-morpholin-4-yl-phenyl)-5-hydroxymethyl-oxazolidine-2-thione
Conditions | Yield |
---|---|
Stage #1: (R)-glycidyl butyrate; 4-(2-fluoro-4-isothiocyanato-phenyl)-morpholine With Triphenylphosphine oxide; lithium bromide In xylene at 110 - 115℃; for 1h; Stage #2: With sodium methylate In methanol at 26 - 28℃; for 2h; Further stages.; | 100% |
Conditions | Yield |
---|---|
With chromium(III) octaethylporphyrinato tetracarbonylcobaltate at 40℃; under 46543.3 Torr; for 6h; | 100% |
(R)-glycidyl butyrate
Conditions | Yield |
---|---|
Stage #1: benzyl (5-iodopyridin-2-yl)carbamate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1.33333h; Inert atmosphere; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran at -78℃; for 1h; Inert atmosphere; | 99% |
(R)-glycidyl butyrate
Conditions | Yield |
---|---|
Stage #1: benzyl (3-((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)carbamate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1.33333h; Inert atmosphere; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran at -78℃; for 1h; Inert atmosphere; | 98% |
2-[4-[[(benzyloxy)carbonyl]amino]-2-fluorophenyl]-hexahydro-1H-spiro[cyclopenta[c]pyrrole-5,2'-[1,3]dioxolane]
(R)-glycidyl butyrate
(5R)-3-(3-fluoro-4-(tetrahydro-1H-spiro[cyclopenta[c]pyrrole-5,2'-[1,3]dioxolane]-2(3H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: 2-[4-[[(benzyloxy)carbonyl]amino]-2-fluorophenyl]-hexahydro-1H-spiro[cyclopenta[c]pyrrole-5,2'-[1,3]dioxolane] With n-butyllithium In tetrahydrofuran at -78℃; for 1h; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran at -78 - 20℃; for 12.5h; Stage #3: With water; ammonium chloride In tetrahydrofuran | 97% |
1-(4-benzyloxycarbonylamino-phenyl)-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester
(R)-glycidyl butyrate
Conditions | Yield |
---|---|
Stage #1: 1-(4-benzyloxycarbonylamino-phenyl)-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; hexane at -78 - 20℃; Stage #3: With ammonium chloride In tetrahydrofuran; hexane | 96% |
1-(4-benzyloxycarbonylamino-phenyl)-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester
(R)-glycidyl butyrate
1-[4-((5R)-hydroxymethyl-2-oxooxazolidin-3-yl)phenyl]-3-azabicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: 1-(4-benzyloxycarbonylamino-phenyl)-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; hexane at -78 - 20℃; | 96% |
N-phenyl methyl carbamate
(R)-glycidyl butyrate
(R)-5-(hydroxymethyl)-3-phenyl-2-oxooxazolidine
Conditions | Yield |
---|---|
Stage #1: N-phenyl methyl carbamate With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1.63333h; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; hexane at -78 - 20℃; for 22.1h; | 95% |
(R)-glycidyl butyrate
Conditions | Yield |
---|---|
Stage #1: benzyl (4-((tert-butyldimethylsilyl)oxy)-3-fluorophenyl)carbamate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1.33333h; Inert atmosphere; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran at -78℃; for 1h; Inert atmosphere; | 94% |
5-(4-benzyloxycarbonylamino-2-fluorophenyl)[1,2,5]triazepane-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester
(R)-glycidyl butyrate
5(R)-(hydroxymethyl)-3-(3-fluoro-4-(1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)[1,2,5]triazepan-5-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: 5-(4-benzyloxycarbonylamino-2-fluorophenyl)[1,2,5]triazepane-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.166667h; Inert atmosphere; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; hexane at -78 - 20℃; for 23.1667h; Inert atmosphere; | 93% |
(R)-glycidyl butyrate
[4-(5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-3-fluoro-phenyl]-carbamic acid benzyl ester
(5R)-3-[4-(5,7-Dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-3-fluorophenyl]-5-(hydroxymethyl)-2-oxazolidinone
Conditions | Yield |
---|---|
Stage #1: [4-(5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-3-fluoro-phenyl]-carbamic acid benzyl ester With n-butyllithium In tetrahydrofuran at -78℃; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran at -78 - 20℃; | 92% |
Stage #1: [4-(5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-3-fluoro-phenyl]-carbamic acid benzyl ester With n-butyllithium In tetrahydrofuran Stage #2: (R)-glycidyl butyrate In tetrahydrofuran at -78 - 20℃; |
(R)-glycidyl butyrate
(5-oxo-5,6,7,8-tetrahydro-naphthalen-2-yl)-carbamic acid benzyl ester
(R)-5-hydroxymethyl-3-(5-oxo-5,6,7,8-tetrahydro-naphthalen-2-yl)-oxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: (5-oxo-5,6,7,8-tetrahydro-naphthalen-2-yl)-carbamic acid benzyl ester With lithium hexamethyldisilazane In tetrahydrofuran at -70℃; for 1h; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran at -70 - 20℃; | 92% |
(R)-glycidyl butyrate
N-benzyloxycarbonyl-3-fluoro-4-(4-phenylpiperazinyl)aniline
(R)-[N-3-(3'-fluoro-4'-(4"-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methanol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride; n-butyllithium In tetrahydrofuran; hexane at -61 - 95℃; for 1h; Inert atmosphere; | 90.86% |
Stage #1: N-benzyloxycarbonyl-3-fluoro-4-(4-phenylpiperazinyl)aniline With n-butyllithium In tetrahydrofuran at -78℃; for 1.33333h; Inert atmosphere; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran at -78 - 20℃; | 77.21% |
Stage #1: N-benzyloxycarbonyl-3-fluoro-4-(4-phenylpiperazinyl)aniline With n-butyllithium In tetrahydrofuran at -78℃; for 1.33333h; Inert atmosphere; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran at -78 - 20℃; for 17h; | 77.21% |
Stage #1: N-benzyloxycarbonyl-3-fluoro-4-(4-phenylpiperazinyl)aniline With n-butyllithium In tetrahydrofuran; hexane at -78℃; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; hexane at -78 - 20℃; |
(R)-glycidyl butyrate
Conditions | Yield |
---|---|
Stage #1: 2,2-dimethyl-propionic acid 4-(4-benzyloxycarbonylamino-2-fluoro-phenoxy)-piperidin-1-yl ester With n-butyllithium at -78℃; Stage #2: (R)-glycidyl butyrate at -78 - 20℃; | 90% |
benzyl [4-(2-oxopyrrolidin-1-yl)phenyl]carbamate
(R)-glycidyl butyrate
(5R)-5-(hydroxymethyl)-3-[4-(2-oxopyrrolidin-1-yl)phenyl]-1,3-oxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: benzyl [4-(2-oxopyrrolidin-1-yl)phenyl]carbamate With n-butyllithium; i-Amyl alcohol In tetrahydrofuran; hexane at -78℃; for 0.166667h; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; hexane at -78 - 20℃; | 90% |
With n-butyllithium In tetrahydrofuran; diethyl ether; hexane; water |
(R)-glycidyl butyrate
Conditions | Yield |
---|---|
Stage #1: C14H12BrNO3 With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1.33333h; Inert atmosphere; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran at -78℃; for 1h; Inert atmosphere; | 90% |
Conditions | Yield |
---|---|
Stage #1: C26H37FN2O3Si With n-butyllithium In tetrahydrofuran at -78℃; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran at -78 - 25℃; | 89% |
(4-benzyloxy-3-fluorophenyl)carbamic acid benzyl ester
(R)-glycidyl butyrate
(R)-3-(4-benzyloxy-3-fluoro-phenyl)-5-(hydroxymethyl)-oxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: (4-benzyloxy-3-fluorophenyl)carbamic acid benzyl ester With lithium hexamethyldisilazane In tetrahydrofuran; hexane at 20℃; for 1h; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; hexane at 0 - 20℃; for 0.5h; Stage #3: With sodium methylate In tetrahydrofuran; methanol; hexane for 0.25h; Reagent/catalyst; Solvent; | 88.5% |
Stage #1: (4-benzyloxy-3-fluorophenyl)carbamic acid benzyl ester With lithium hexamethyldisilazane In tetrahydrofuran; hexane at 20℃; for 1h; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; hexane at 0℃; for 0.5h; Stage #3: With sodium methylate In tetrahydrofuran; methanol; hexane at 20℃; for 0.25h; | 88.5% |
Stage #1: (4-benzyloxy-3-fluorophenyl)carbamic acid benzyl ester With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; hexane for 0.5h; | 87% |
With n-butyllithium at -60℃; for 24h; | 80% |
With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; for 0.25h; Cooling with acetone-dry ice; | 65.5% |
C28H37FN4O6
(R)-glycidyl butyrate
5(R)-(hydroxymethyl)-3-(3-fluoro-4-(1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)[1,2,5]triazepan-5-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: C28H37FN4O6 With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.166667h; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; hexane at 20℃; for 0.333333h; Stage #3: With potassium carbonate In methanol at 20℃; for 6h; | 88% |
Stage #1: C28H37FN4O6 With n-butyllithium In tetrahydrofuran; hexane at -78℃; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; hexane at -78 - 20℃; Stage #3: With potassium carbonate In methanol at 20℃; for 6h; | 88% |
(3,4-Dichloro-phenyl)-carbamic acid benzyl ester
(R)-glycidyl butyrate
C10H9Cl2NO3
Conditions | Yield |
---|---|
Stage #1: (3,4-Dichloro-phenyl)-carbamic acid benzyl ester With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.75h; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; hexane at -78 - 20℃; | 88% |
(R)-glycidyl butyrate
N-carbobenzoxy-3-fluoro-4-(N-carbobenzoxypiperazin-1-yl)aniline
(R)-[N-3-[3-fluoro-4-[N-1-(4-carbobenzoxy)piperazinyl]-phenyl]-2-oxo-5-oxazolidinyl]methanol
Conditions | Yield |
---|---|
Stage #1: N-carbobenzoxy-3-fluoro-4-(N-carbobenzoxypiperazin-1-yl)aniline With n-butyllithium In tetrahydrofuran; hexane at -78℃; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; hexane at -60 - 20℃; | 87% |
Stage #1: N-carbobenzoxy-3-fluoro-4-(N-carbobenzoxypiperazin-1-yl)aniline With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1.63333h; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; hexane at -78 - 20℃; for 22.1h; | 85% |
Stage #1: N-carbobenzoxy-3-fluoro-4-(N-carbobenzoxypiperazin-1-yl)aniline With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1.5h; Inert atmosphere; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; hexane at -78 - 20℃; for 4.5h; | 82% |
With n-butyllithium 1.) THF, hexane, -78 deg C, 1.5 h, 2.) THF, hexane, a) -78 deg C, 1 h, b) RT, 3.5 h; Yield given. Multistep reaction; | |
With n-butyllithium In tetrahydrofuran at -78℃; Inert atmosphere; |
(1α,5α,6α)-3-(4-benzyloxycarbonylamino-2,6-difluorophenyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid tert-butyl ester
(R)-glycidyl butyrate
(R)-(1α,5α,6α)-3-[2,6-difluoro-4-(5-hydroxymethyl-2-oxooxazolidin-3-yl)phenyl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: (1α,5α,6α)-3-(4-benzyloxycarbonylamino-2,6-difluorophenyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid tert-butyl ester With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1.5h; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran at 20℃; for 16h; | 87% |
5-(4-benzyloxycarbonylamino-2,6-difluorophenyl)[1,2,5]oxadiazepane-2-carboxylic acid tert-butyl ester
(R)-glycidyl butyrate
5(R)-(hydroxymethyl)-3-(3,5-difluoro-4-(2-(tertbutoxycarbonyl)[1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: 5-(4-benzyloxycarbonylamino-2,6-difluorophenyl)[1,2,5]oxadiazepane-2-carboxylic acid tert-butyl ester With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.166667h; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; hexane at -78 - 20℃; for 19.1667h; Stage #3: With potassium carbonate In methanol for 0.25h; | 87% |
Stage #1: 5-(4-benzyloxycarbonylamino-2,6-difluorophenyl)[1,2,5]oxadiazepane-2-carboxylic acid tert-butyl ester With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.166667h; Inert atmosphere; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; hexane at -78 - 20℃; for 23.1667h; Inert atmosphere; | 87% |
Stage #1: 5-(4-benzyloxycarbonylamino-2,6-difluorophenyl)[1,2,5]oxadiazepane-2-carboxylic acid tert-butyl ester; (R)-glycidyl butyrate With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; for 19.3h; Inert atmosphere; Stage #2: With potassium carbonate In methanol for 0.25h; | 87% |
[4-(3,6-dihydro-2H-pyridin-1-yl)-3-fluoro-phenyl]-carbamic acid benzyl ester
(R)-glycidyl butyrate
3-[4-(3,6-dihydro-2H-pyridin-1-yl)-3-fluoro-phenyl]-5-hydroxymethyl-oxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: [4-(3,6-dihydro-2H-pyridin-1-yl)-3-fluoro-phenyl]-carbamic acid benzyl ester With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.5h; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran at -78 - 20℃; | 87% |
(4-bromo-3-fluorophenyl)carbamic acid benzyl ester
(R)-glycidyl butyrate
(5R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With lithium tert-butoxide In tetrahydrofuran; methanol; N,N-dimethyl-formamide at 0 - 20℃; for 3h; | 87% |
Stage #1: (4-bromo-3-fluorophenyl)carbamic acid benzyl ester With lithium tert-butoxide In tetrahydrofuran; N,N-dimethyl-formamide at 0℃; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; methanol; N,N-dimethyl-formamide at 20℃; for 3h; | 87% |
Stage #1: (4-bromo-3-fluorophenyl)carbamic acid benzyl ester With n-butyllithium In tetrahydrofuran; hexane; tert-butyl alcohol at 0℃; for 0.5h; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; hexane; tert-butyl alcohol at 0 - 20℃; | 86.4% |
4-(((benzyloxy)carbonyl)amino)-2-fluorobenzoic acid
(R)-glycidyl butyrate
Conditions | Yield |
---|---|
Stage #1: 4-(((benzyloxy)carbonyl)amino)-2-fluorobenzoic acid With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1.33333h; Inert atmosphere; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran at -78℃; for 1h; Inert atmosphere; | 87% |
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