Our advantage Free sample and unconditional assume respons 100% natural porduct, without any synthetize ingredient Manufacturer direct supply, provide OEM, R&D service ISO/HACCP/KOSHER/GMP/FDA Leading plant extract manufact
latin name: artemisia annua l. cas no.: 63968-64-9 specification: artemisinin 98% test:hplc molecular formula: c15h22o5 molecular weight: 282.34 appearance: white crystalline fine powder origin:china appearance:fine white po
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inquiryannual artemisia P.E. Latin Name: Artemisia annua L. CAS No.: 63968-64-9 Specification: Artemisinin 98% Test:HPLC Molecular Formula: C15H22O5 Molecular Weight: 282.34 Appearance: White crystalline fine powder Origin:Ch
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inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:63968-64-9
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inquiryItems Standard Result Appearance White powder Complies Assay(HPLC) 98%min 99.8%
Cas:63968-64-9
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:63968-64-9
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inquiryAbout us We are a Professionally Managed Biotech Company exclusively into the manufacturing, Marketing and Exporting of Plant Extracts and Health Care Products.There are 15 experts in our research team. We insist in innovation and pr
Cas:63968-64-9
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:63968-64-9
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inquiryUnique advantages of Artemisinin Cas 63968-64-9 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:Cool dry place Package:1kg/foill bag;25
Cas:63968-64-9
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inquiryWe are: Focus on the research, production and sale of Plant and Animal extract, Medical intermediate, complete coverage six industries. Product grade: Medicine, Health care product, Cosmetics, Food,Feed, Biopesticide. Hot selling market: Europe,
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:63968-64-9
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inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:63968-64-9
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inquiryArteannuin CAS No.:63968-64-9 Appearance:white Storage:cool and dry Package:durm Application:api Transportation:by sea or by air Port:shanghai
Cas:63968-64-9
Min.Order:0 Metric Ton
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:artemisinin CAS no:63968-64-9 Grade:Scientific research and export Molecular formula:C15H22O5 Molecular weight:282.3322 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage
Cas:63968-64-9
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Type:Other
inquiryArtemisinin Basic information Product Name: Artemisinin Synonyms: [3r-(3r,5as,6s,8as,9r,10r,12s,12ar**)]-decahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-
Cas:63968-64-9
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:63968-64-9
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:63968-64-9
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in t
Cas:63968-64-9
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inquirycas 32499-92-6 99 % D-glucuronolactone powder Product Name: D-GLUCURONO-3,6-LACTONE CAS: 32499-92-6 MF: C6H8O6 MW: 176.12 EINECS: 251-053-3 Appearance:white Storage:room Package:drum Application:Artemisia annua is used as antim
Cas:63968-64-9
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryProduct name Artemisinin Appearance White Crystal Powder CAS No. 63968-64-9 MF C15H22O5 Purity 99% Appearance:White Crystal Powder Storage:Store in cool and dry place, away from sun li
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:powder Storage:Store in sealed containers at cool & dry pla
Cas:63968-64-9
Min.Order:100 Gram
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Type:Other
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate
Cas:63968-64-9
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Type:Lab/Research institutions
inquiryWe have two GMP facilities in Hubei Province and cooperative factories in Zhejiang Province We are concentrating on the R&D and technical service of APIs and pharmaceutical intermediates FDA Approved Appearance:Clear colorless Storage:2-8
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inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
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Min.Order:10 Gram
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Type:Trading Company
inquiryArtemisinin CAS:63968-64-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates
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Min.Order:1 Gram
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Type:Lab/Research institutions
inquirybest price,best quality and fast delivery assurance available in sample product and customization with years of export experience along with excellent quality, advanced services and competitive prices the quality of products conform u
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inquiryC12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
With [bis(acetoxy)iodo]benzene; magnesium oxide; Rh2(fb)4 In dichloromethane for 24h; Heating; | 96% |
4α-hydroperoxy-amorph-5-en-12-oic acid
A
C12H13O2(CH3)3(O)(OO)
B
(3R,3a,6R,6aS,10aS)-3a,4,5,6,6a,7,8,8a-octahydro-3,6,9-trimethylnaphtho[8a,1-b]furan-2(3H)-one
Conditions | Yield |
---|---|
With oxygen; trifluoroacetic acid In toluene Flow reactor; chemoselective reaction; | A 81% B 7% |
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃; for 12h; Inert atmosphere; | 75% |
4α-hydroperoxy-amorph-5-en-12-oic acid
C12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
With oxygen; copper(I) triflate at 20℃; Temperature; | 65% |
(3R)-dihydroarteannuin B acid methyl carbonate
C12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
With oxygen; trifluoroacetic acid; 5,10,15,20-tetraphenyl-21H,23H-porphine In dichloromethane at -10 - 20℃; for 22h; Photochemical reaction; | 62.2% |
(3R)-dihydroarteannuin B acid ethyl carbonate
C12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
With oxygen; trifluoroacetic acid; 5,10,15,20-tetraphenyl-21H,23H-porphine In dichloromethane at -10 - 20℃; for 22h; Photochemical reaction; | 62% |
With 5,10,15,20-tetraphenyl-21H,23H-porphine; trifluoroacetic acid In dichloromethane at -15 - -10℃; Irradiation; Industrial scale; | 370 kg |
(3R)-dihydroarteannuin B acid benzyl carbonate
C12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
With oxygen; trifluoroacetic acid; 5,10,15,20-tetraphenyl-21H,23H-porphine In dichloromethane at -10 - 20℃; for 22h; Photochemical reaction; | 59.2% |
dihydroartemisinic acid
A
C12H13O2(CH3)3(O)(OO)
B
arteanniun H
Conditions | Yield |
---|---|
Stage #1: dihydroartemisinic acid With oxygen; 5,15,10,20-tetraphenylporphyrin In dichloromethane Irradiation; High pressure; Stage #2: With oxygen; trifluoroacetic acid In dichloromethane; toluene at 25℃; for 0.333333h; | A 59.1% B 6.1% |
Multi-step reaction with 2 steps 1: 5,15,10,20-tetraphenylporphyrin; oxygen / dichloromethane / -20 °C / Flow reactor; UV-irradiation 2: trifluoroacetic acid; oxygen / toluene / 0.33 h / 25 °C / 750.08 Torr / Flow reactor View Scheme | |
Multi-step reaction with 2 steps 1: 5,15,10,20-tetraphenylporphyrin; oxygen / dichloromethane / -20 °C / Flow reactor; UV-irradiation 2: trifluoroacetic acid; oxygen / toluene / 0.33 h / 50 °C / 750.08 Torr / Flow reactor View Scheme | |
Multi-step reaction with 2 steps 1: 5,15,10,20-tetraphenylporphyrin; oxygen / dichloromethane / 60 °C / Flow reactor; UV-irradiation 2: trifluoroacetic acid; oxygen / toluene / 0.33 h / 25 °C / 750.08 Torr / Flow reactor View Scheme | |
Multi-step reaction with 2 steps 1: 5,15,10,20-tetraphenylporphyrin; oxygen / dichloromethane / 60 °C / Flow reactor; UV-irradiation 2: trifluoroacetic acid; oxygen / toluene / 0.33 h / 50 °C / 750.08 Torr / Flow reactor View Scheme |
(3R)-dihydroarteannuin B acid 2,2,2-trichloroethyl carbonate
C12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
With oxygen; trifluoroacetic acid; 5,10,15,20-tetraphenyl-21H,23H-porphine In dichloromethane at -10 - 20℃; for 22h; Photochemical reaction; | 58.7% |
(3R)-dihydroarteannuin B acid phenyl carbonate
C12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
With oxygen; trifluoroacetic acid; 5,10,15,20-tetraphenyl-21H,23H-porphine In dichloromethane at -10 - 20℃; for 22h; Photochemical reaction; | 58.4% |
dihydroartemisinic acid
A
C12H13O2(CH3)3(O)(OO)
B
(4R,4aS,7R,8S)-4,7-Dimethyl-8-(3-oxo-butyl)-4,4a,5,6,7,8-hexahydro-isochromen-3-one
Conditions | Yield |
---|---|
Stage #1: dihydroartemisinic acid With oxygen; 5,15,10,20-tetraphenylporphyrin In dichloromethane Irradiation; High pressure; Stage #2: With oxygen; trifluoroacetic acid In dichloromethane; toluene at 0℃; for 1h; Solvent; Temperature; Time; | A 55.6% B 6.8% |
Stage #1: dihydroartemisinic acid With oxygen; 5,15,10,20-tetraphenylporphyrin In dichloromethane Irradiation; High pressure; Stage #2: With oxygen; trifluoroacetic acid In dichloromethane; toluene at -15℃; for 0.333333h; | A 18% B 21.3% |
Multi-step reaction with 2 steps 1: 5,15,10,20-tetraphenylporphyrin; oxygen / dichloromethane / -20 °C / Flow reactor; UV-irradiation 2: trifluoroacetic acid; oxygen / toluene / 1 h / 0 °C / 750.08 Torr / Flow reactor View Scheme | |
Multi-step reaction with 2 steps 1: 5,15,10,20-tetraphenylporphyrin; oxygen / dichloromethane / 60 °C / Flow reactor; UV-irradiation 2: trifluoroacetic acid; oxygen / toluene / 1 h / 0 °C / 750.08 Torr / Flow reactor View Scheme |
(3R)-dihydroarteannuin B acid 2-chloroethyl carbonate
C12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
With oxygen; trifluoroacetic acid; 5,10,15,20-tetraphenyl-21H,23H-porphine In dichloromethane at -10 - 20℃; for 22h; Photochemical reaction; | 54.9% |
(3R)-dihydroarteannuin B acid propyl carbonate
C12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
With oxygen; trifluoroacetic acid; 5,10,15,20-tetraphenyl-21H,23H-porphine In dichloromethane at -10 - 20℃; for 22h; Photochemical reaction; | 54.5% |
dihydroartemisinic acid
C12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
Stage #1: dihydroartemisinic acid With oxygen; 5,15,10,20-tetraphenylporphyrin In dichloromethane under 8625.86 Torr; Stage #2: With oxygen; trifluoroacetic acid In dichloromethane at 0℃; for 2h; | 50% |
Stage #1: dihydroartemisinic acid With oxygen; 5,15,10,20-tetraphenylporphyrin In dichloromethane under 8625.86 Torr; UV-irradiation; Stage #2: With oxygen; trifluoroacetic acid In dichloromethane at 0℃; under 760.051 Torr; for 2h; Pressure; Temperature; Solvent; | 50% |
Stage #1: dihydroartemisinic acid With oxygen; 5,15,10,20-tetraphenylporphyrin In dichloromethane at 0℃; under 760.051 Torr; for 0.0333333h; Stage #2: With trifluoroacetic acid In dichloromethane at 0℃; for 2h; Time; Temperature; Concentration; UV-irradiation; | 50% |
dihydroartemisinic acid
C12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
With porphyrin; trifluoroacetic acid In toluene at 25℃; Temperature; Reagent/catalyst; Irradiation; | 50% |
(+)-deoxoartemisinin
C12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
With ruthenium trichloride; sodium periodate | 49% |
dihydroartemisinic acid
A
C12H13O2(CH3)3(O)(OO)
B
(3R,3a,6R,6aS,10aS)-3a,4,5,6,6a,7,8,8a-octahydro-3,6,9-trimethylnaphtho[8a,1-b]furan-2(3H)-one
C
arteanniun H
Conditions | Yield |
---|---|
Stage #1: dihydroartemisinic acid With oxygen; 5,15,10,20-tetraphenylporphyrin In dichloromethane Irradiation; High pressure; Stage #2: With oxygen; trifluoroacetic acid In dichloromethane; toluene at 50℃; for 0.333333h; | A 47% B 5.5% C 7.2% |
5α-hydroperoxy-amorph-5-en-12-oic acid methyl ester
A
C12H13O2(CH3)3(O)(OO)
C
(R)-2-[(1S,3S,4R)-2-Formyl-2-[(2R,4aS,5R,8S)-8-((R)-1-methoxycarbonyl-ethyl)-2,5-dimethyl-2,3,4,4a,5,6,7,8-octahydro-naphthalen-2-ylperoxy]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester
Conditions | Yield |
---|---|
In chloroform-d1 for 2556.75h; Further byproducts given; | A 3% B 40% C 4% D n/a |
dihydroartemisinic acid
A
C12H13O2(CH3)3(O)(OO)
B
(3R,3a,6R,6aS,10aS)-3a,4,5,6,6a,7,8,8a-octahydro-3,6,9-trimethylnaphtho[8a,1-b]furan-2(3H)-one
C
(4R,4aS,7R,8S)-4,7-Dimethyl-8-(3-oxo-butyl)-4,4a,5,6,7,8-hexahydro-isochromen-3-one
D
arteanniun H
Conditions | Yield |
---|---|
Stage #1: dihydroartemisinic acid With oxygen; 5,15,10,20-tetraphenylporphyrin In dichloromethane Irradiation; High pressure; Stage #2: With oxygen; trifluoroacetic acid In dichloromethane; toluene at 75℃; for 0.333333h; | A 31.2% B 6.1% C 9.6% D 7.5% |
4-((7R,8S)-3-methoxy-4,7-dimethyl-3-((triisopropylsilyl)oxy)-4,4a,5,6,7,8-hexahydro-3H-isochromen-8-yl)butan-2-one
C12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
Stage #1: 4-((7R,8S)-3-methoxy-4,7-dimethyl-3-((triisopropylsilyl)oxy)-4,4a,5,6,7,8-hexahydro-3H-isochromen-8-yl)butan-2-one With ammonium molibdate; dihydrogen peroxide In water; tert-butyl alcohol at 20℃; for 72h; Stage #2: With toluene-4-sulfonic acid In dichloromethane at 20℃; for 72h; | 29% |
(R)-2-[(1S,3S,4R)-2-[1-Methoxy-meth-(Z)-ylidene]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester
C12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
Stage #1: (R)-2-[(1S,3S,4R)-2-[1-Methoxy-meth-(Z)-ylidene]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester With hydrogenchloride; oxygen; rose bengal In methanol at -78℃; for 4h; UV-irradiation; Stage #2: With perchloric acid for 28h; | 10% |
Conditions | Yield |
---|---|
With Aspergillus niger NRRL 599; culture medium In water; acetone at 25℃; for 240h; Hydrogenation; oxidation; deoxygenation; | A n/a B 8.9% C 5.5% D 7.1% |
artemisinic acid
A
C12H13O2(CH3)3(O)(OO)
B
(1R,5S,8R,9S,12R,14R)-8,12-dimethyl-4-methylidene-2,13-dioxatetracyclo[7.5.0.01,5.012,14]tetradecan-3-one
Conditions | Yield |
---|---|
In water at 30℃; for 2h; cell-free extract from Artemisia annua L. (Asteraceae), EDTA, HEPES with DDT buffer, pH 7.15; Title compound not separated from byproducts; |
(2R,1'S,3'S,4'S)-2-<4'-methyl-3'-(3''-oxobutyl)-2'(E)-<(trimethylsilyl)methylene>cyclohexyl>propionic acid
C12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
With ozone; trifluoroacetic acid 1.) MeOH, -78 deg C, 2.) CHCl3, H2O; Yield given. Multistep reaction; |
(2R,1'S,3'S,4'S)-2-<4'-methyl-3'-(3''-oxobutyl)-2'(E)-<(trimethylsilyl)methylene>cyclohexyl>propionic acid
A
C12H13O2(CH3)3(O)(OO)
B
2-deoxyartemisinin
Conditions | Yield |
---|---|
With oxygen; ozone; trifluoroacetic acid 1.) CH2Cl2, -78 deg C, 2.) CDCl3; Yield given. Multistep reaction. Yields of byproduct given; |
2,5,5-trimethyl-2-<2'-<4''-(1(S)-carboxyethyl)-1''(R)-methyl-3''-<(trimethylsilyl)methylene>cyclohex-2''-yl>ethyl>-1,3-dioxane
A
C12H13O2(CH3)3(O)(OO)
B
2-deoxyartemisinin
Conditions | Yield |
---|---|
With 2,6-di-tert-butyl-4-methyl-phenol; sulfuric acid; oxygen; silica gel; ozone 1.) CH2Cl2, -78 deg C, 2 min, 2.) CH2Cl2, 22 deg C, overnight; Yield given. Multistep reaction. Yields of byproduct given; |
C12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
With formic acid; oxygen 1.) MeOH, irradiation, -78 ded C, 2.) CH2Cl2, 0 deg C, 24 h; Yield given; |
C12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
Yield given. Multistep reaction; |
C12H13O2(CH3)3(O)(OO)
dihydroartemisinin
Conditions | Yield |
---|---|
With diisobutylaluminium hydride In dichloromethane at -78℃; for 1.25h; | 100% |
With methanol; sodium tetrahydroborate at 0℃; for 3h; Inert atmosphere; | 100% |
With sodium tetrahydroborate In methanol at 0 - 20℃; for 0.5h; Inert atmosphere; Green chemistry; | 98% |
With sodium tetrahydroborate In methanol at 0℃; for 1h; | 91% |
With sodium tetrahydroborate In methanol at 0 - 5℃; for 3h; | 79% |
C12H13O2(CH3)3(O)(OO)
dihydroartesiminin
Conditions | Yield |
---|---|
With sodium tetrahydroborate; N-benzyl-N,N,N-triethylammonium chloride In water; toluene at -10 - 0℃; for 5h; Solvent; Inert atmosphere; Large scale; | 99.6% |
With sodium tetrahydroborate In methanol at 0℃; | |
With diisobutylaluminium hydride at -78℃; |
C12H13O2(CH3)3(O)(OO)
dihydroartemisinin
Conditions | Yield |
---|---|
With methanol; sodium tetrahydroborate at 0℃; for 3h; | 98% |
With sodium tetrahydroborate In methanol at 0 - 5℃; for 3.33333h; | 97.15% |
With sodium tetrahydroborate In methanol for 1.25h; | 96% |
C12H13O2(CH3)3(O)(OO)
2-deoxyartemisinin
Conditions | Yield |
---|---|
With zinc In acetic acid for 2.5h; Ambient temperature; | 98% |
With hydrogen; Lindlar's catalyst In methanol for 10h; | 88% |
With hydrogen; Lindlar's catalyst In methanol Ambient temperature; | 86% |
Conditions | Yield |
---|---|
Stage #1: C12H13O2(CH3)3(O)(OO) With sodium tetrahydroborate; cation exchange resin In tetrahydrofuran at 20 - 35℃; for 0.666667h; Stage #2: succinic acid anhydride With triethylamine In tetrahydrofuran at 20 - 35℃; for 1h; | 96% |
Stage #1: C12H13O2(CH3)3(O)(OO) With sodium tetrahydroborate; D-glucose In 1,4-dioxane at 20 - 30℃; for 2h; Stage #2: succinic acid anhydride In 1,4-dioxane at 20 - 30℃; for 2h; | 93% |
Stage #1: C12H13O2(CH3)3(O)(OO) With sodium tetrahydroborate; cation exchange resin In tetrahydrofuran at 20 - 35℃; for 0.75h; Stage #2: succinic acid anhydride With sodium hydrogencarbonate In tetrahydrofuran at 20 - 35℃; for 1.25h; | 93% |
C12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
With sodium phosphite; phosphite dehydrogenase; P450 variant IV-H4; oxygen; nicotinamide adenine dinucleotide phosphate In aq. phosphate buffer at 20℃; for 12h; pH=8; Reagent/catalyst; Time; | 92% |
C12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
With sodium phosphite; phosphite dehydrogenase; P450 variant II-H10; oxygen; nicotinamide adenine dinucleotide phosphate In aq. phosphate buffer at 20℃; for 12h; pH=8; | 91% |
methanol
C12H13O2(CH3)3(O)(OO)
A
(R)-2-((1R,4S,4aR,7R,9aS)-4a-Formyl-7-hydroxy-1,7-dimethyl-octahydro-5,6-dioxa-benzocyclohepten-4-yl)-propionic acid methyl ester
B
(R)-2-[(1S,3S,4R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester
Conditions | Yield |
---|---|
With sulfuric acid for 0.166667h; | A n/a B 90% |
Conditions | Yield |
---|---|
Stage #1: C12H13O2(CH3)3(O)(OO) With sodium tetrahydroborate Stage #2: acetyl chloride With pyridine | 90% |
C12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
With sodium phosphite; phosphite dehydrogenase; P450 variant X-F11; oxygen; nicotinamide adenine dinucleotide phosphate In aq. phosphate buffer at 20℃; for 12h; pH=8; Reagent/catalyst; Time; | 90% |
Conditions | Yield |
---|---|
Stage #1: C12H13O2(CH3)3(O)(OO) With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.75h; Stage #2: dehydroqinghaosu In tetrahydrofuran at -78℃; for 5h; Further stages.; | 88% |
C12H13O2(CH3)3(O)(OO)
(trifluoromethyl)trimethylsilane
(1S,4R,5R,8R,9R,10R,12R,13R)-1,5,9-trimethyl-10-(trifluoromethyl)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In tetrahydrofuran for 25h; Ambient temperature; | 87% |
C12H13O2(CH3)3(O)(OO)
A
(3aS,4R,6aS,7R,10S,10aR)-10-(acetyloxy)octahydro-4,7-dimethyl-8H,10H-furo[3,2-i][2]benzopyran-8-one
Conditions | Yield |
---|---|
With pyridine; iron(III) chloride In acetonitrile for 36h; | A 85% B 8% |
With meso-tetraphenylporphyrin iron(III) chloride; N-acetylcystein In dichloromethane for 0.75h; | A 74% B n/a |
With 1H-imidazole; iron(III) trifluoromethanesulfonate; N-acetylcystein In acetonitrile for 18h; | A 41% B 50% |
C12H13O2(CH3)3(O)(OO)
9-fluoroartemisinin
Conditions | Yield |
---|---|
Stage #1: C12H13O2(CH3)3(O)(OO) With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1h; Stage #2: With N-fluorobenzene sulfonamide In tetrahydrofuran at -78℃; for 1h; Further stages.; | 85% |
C12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
Stage #1: C12H13O2(CH3)3(O)(OO) With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: With N,N,N,N,N,N-hexamethylphosphoric triamide In tetrahydrofuran; hexane at -78℃; Inert atmosphere; Stage #3: allyl halogenide With diethylzinc In tetrahydrofuran; hexane at -78 - 20℃; Inert atmosphere; | 82% |
C12H13O2(CH3)3(O)(OO)
(trifluoromethyl)trimethylsilane
trimethylsilyl (1S,4R,5R,8R,9R,10R,12S,13R)-1,5,9-trimethyl-10-(trifluoromethyl)-11,14,15,16-tetraoxatetracyclo[10.3.1.0.4,1308,13]hexadec-10-yl ether
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In tetrahydrofuran at 0 - 20℃; for 7h; | 79% |
Conditions | Yield |
---|---|
Stage #1: C12H13O2(CH3)3(O)(OO) With sodium tetrahydroborate; amberlyst-15 In tetrahydrofuran at 20℃; for 0.5h; Stage #2: propan-1-ol In dichloromethane at 20℃; for 72h; | 79% |
C12H13O2(CH3)3(O)(OO)
A
(3aS,4R,6aS,7R,10S,10aR)-10-(acetyloxy)octahydro-4,7-dimethyl-8H,10H-furo[3,2-i][2]benzopyran-8-one
Conditions | Yield |
---|---|
With iron(II) chloride In acetonitrile for 0.0333333h; Mechanism; Ambient temperature; | A 78% B 17% |
With iron(II) chloride In acetonitrile for 0.25h; Ambient temperature; | A 78% B 17% |
C12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
With sodium borodeuteride In methanol for 1h; Reduction; | 77% |
Conditions | Yield |
---|---|
Stage #1: C12H13O2(CH3)3(O)(OO); (trifluoromethyl)trimethylsilane With tetrabutyl ammonium fluoride In tetrahydrofuran at 0℃; for 2h; Stage #2: With water at 20℃; for 0.5h; Further stages.; | 77% |
C12H13O2(CH3)3(O)(OO)
(R)-2-[(1S,3S,4R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester
Conditions | Yield |
---|---|
With sulfuric acid In methanol | 75% |
With iron(III) chloride In diethyl ether for 1.5h; | |
With trifluoroacetic acid In methanol Heating; |
C12H13O2(CH3)3(O)(OO)
Conditions | Yield |
---|---|
With sodium tetrahydroborate; boron trifluoride diethyl etherate In tetrahydrofuran | 75% |
Multi-step reaction with 2 steps 1: 100 percent / DIBAL-H / CH2Cl2 / 1.25 h / -78 °C 2: 1.) Et3SiH, 2.) BF3*OEt2 / 1.) CH2Cl2, -78 deg C, 10 min, 2.) CH2Cl2, -78 deg C, 3 h View Scheme |
Conditions | Yield |
---|---|
Stage #1: C12H13O2(CH3)3(O)(OO) With sodium tetrahydroborate; amberlyst-15 In tetrahydrofuran at 20℃; for 0.5h; Stage #2: pentan-1-ol In dichloromethane at 20℃; for 56h; | 74% |
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In benzene for 17h; Reflux; | 74% |
methanol
C12H13O2(CH3)3(O)(OO)
(R)-methyl 2-((3R,6R,9aR)-9a-formyl-3-methoxy-3,6-dimethyloctahydro-3H-benzo[c][1,2]dioxepin-9-yl)propanoate
Conditions | Yield |
---|---|
With trifluoroacetic acid for 5h; Reflux; | 73% |
With sulfuric acid for 3h; Yield given; |
Conditions | Yield |
---|---|
Stage #1: C12H13O2(CH3)3(O)(OO) With sodium tetrahydroborate; amberlyst-15 In tetrahydrofuran at 20℃; for 0.5h; Stage #2: Butane-1,4-diol In dichloromethane at 20℃; for 55h; | 73% |
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