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Xian Changyue Biological Technology Co., Ltd.

Our advantage Free sample and unconditional assume respons 100% natural porduct, without any synthetize ingredient Manufacturer direct supply, provide OEM, R&D service ISO/HACCP/KOSHER/GMP/FDA Leading plant extract manufact

Artemisinin

Cas:63968-64-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Weihai Moochun Bio-Tech Co., Ltd.

latin name: artemisia annua l. cas no.: 63968-64-9 specification: artemisinin 98% test:hplc molecular formula: c15h22o5 molecular weight: 282.34 appearance: white crystalline fine powder origin:china appearance:fine white po

GMP factory manufacturing Artemisia annua extract

Cas:63968-64-9

Min.Order:0 Metric Ton

FOB Price: $280.0 / 291.0

Type:Trading Company

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Greenutra Resource Inc

annual artemisia P.E. Latin Name: Artemisia annua L. CAS No.: 63968-64-9 Specification: Artemisinin 98% Test:HPLC Molecular Formula: C15H22O5 Molecular Weight: 282.34 Appearance: White crystalline fine powder Origin:Ch

Artemisia annua extract

Cas:63968-64-9

Min.Order:1 Kilogram

FOB Price: $240.0

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Artemisinin

Cas:63968-64-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White powder Complies Assay(HPLC) 98%min 99.8%

High purity Various Specifications artemisinin CAS:63968-64-9

Cas:63968-64-9

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Artemisinin supplier in China

Cas:63968-64-9

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

About us We are a Professionally Managed Biotech Company exclusively into the manufacturing, Marketing and Exporting of Plant Extracts and Health Care Products.There are 15 experts in our research team. We insist in innovation and pr

Artemisinin 63968-64-9

Cas:63968-64-9

Min.Order:1 Kilogram

FOB Price: $800.0 / 1000.0

Type:Other

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

artemisinin CAS NO.63968-64-9

Cas:63968-64-9

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Artemisinin Cas 63968-64-9 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:Cool dry place Package:1kg/foill bag;25

Pure Artemisia annua extract Artemisinin Cas 63968-64-9 with high quality and best price

Cas:63968-64-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xi'an Quanao Biotech Co., Ltd.

We are: Focus on the research, production and sale of Plant and Animal extract, Medical intermediate, complete coverage six industries. Product grade: Medicine, Health care product, Cosmetics, Food,Feed, Biopesticide. Hot selling market: Europe,

Pharmaceutical Using Artemisia Annua Leaf Extract Artemisinin 98% Powder

Cas:63968-64-9

Min.Order:1 Kilogram

FOB Price: $290.0 / 295.0

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Artemisinin 63968-64-9 GMP Manufacturer

Cas:63968-64-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Artemisinin

Cas:63968-64-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.

Arteannuin CAS No.:63968-64-9 Appearance:white Storage:cool and dry Package:durm Application:api Transportation:by sea or by air Port:shanghai

Arteannuin CAS No.:63968-64-9

Cas:63968-64-9

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Artemisinin

Cas:63968-64-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:artemisinin CAS no:63968-64-9 Grade:Scientific research and export Molecular formula:C15H22O5 Molecular weight:282.3322 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage

artemisinin/cas:63968-64-9/high quality/artemisinin material

Cas:63968-64-9

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Artemisinin Basic information Product Name: Artemisinin Synonyms: [3r-(3r,5as,6s,8as,9r,10r,12s,12ar**)]-decahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-

TIANFU-CHEM Artemisinin 63968-64-9

Cas:63968-64-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Artemisinin Extract Powder CAS:63968-64-9

Cas:63968-64-9

Min.Order:1 Kilogram

FOB Price: $10.0 / 16.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 63968-64-9 with best quality

Cas:63968-64-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

favorable quality artemisinin,artemisinin affordable price,63968-64-9 definition

Cas:63968-64-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in t

Bulk supply pure herbal artemisinin artemisia annua extract powder 99% artemisinin CAS NO.63968-64-9

Cas:63968-64-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Vanz Pharm Co.,Ltd

cas 32499-92-6 99 % D-glucuronolactone powder Product Name: D-GLUCURONO-3,6-LACTONE CAS: 32499-92-6 MF: C6H8O6 MW: 176.12 EINECS: 251-053-3 Appearance:white Storage:room Package:drum Application:Artemisia annua is used as antim

cas 32499-92-6 99 % D-glucuronolactone powder

Cas:63968-64-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product name Artemisinin Appearance White Crystal Powder CAS No. 63968-64-9 MF C15H22O5 Purity 99% Appearance:White Crystal Powder Storage:Store in cool and dry place, away from sun li

Artemisinin CAS:63968-64-9

Cas:63968-64-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:powder Storage:Store in sealed containers at cool & dry pla

High Assay Artemisinin CAS No.: 63968-64-9 Plant Extract

Cas:63968-64-9

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate

Topsale Artemisia 63968-64-9 /annua extract

Cas:63968-64-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

We have two GMP facilities in Hubei Province and cooperative factories in Zhejiang Province We are concentrating on the R&D and technical service of APIs and pharmaceutical intermediates FDA Approved Appearance:Clear colorless Storage:2-8

GMP Factory Price Pharmaceutical Chemical High Purity 99% Artemisinin in Stock

Cas:63968-64-9

Min.Order:1 Kilogram

FOB Price: $150.0

Type:Trading Company

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Treatment of malaria drugs Artemisinin with CAS:63968-64-9

Cas:63968-64-9

Min.Order:1 Kilogram

FOB Price: $319.0 / 330.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Artemisinin CAS:63968-64-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Artemisinin CAS:63968-64-9

Cas:63968-64-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

best price,best quality and fast delivery assurance available in sample product and customization with years of export experience along with excellent quality, advanced services and competitive prices the quality of products conform u

Natural sweet wormwood Artemisia carvifolia Extract 98% Artemisinin CAS NO.63968-64-9

Cas:63968-64-9

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Synthetic route

(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl carbamate

(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl carbamate

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

Conditions
ConditionsYield
With [bis(acetoxy)iodo]benzene; magnesium oxide; Rh2(fb)4 In dichloromethane for 24h; Heating;96%
4α-hydroperoxy-amorph-5-en-12-oic acid
85031-60-3

4α-hydroperoxy-amorph-5-en-12-oic acid

A

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

B

(3R,3a,6R,6aS,10aS)-3a,4,5,6,6a,7,8,8a-octahydro-3,6,9-trimethylnaphtho[8a,1-b]furan-2(3H)-one
104196-16-9

(3R,3a,6R,6aS,10aS)-3a,4,5,6,6a,7,8,8a-octahydro-3,6,9-trimethylnaphtho[8a,1-b]furan-2(3H)-one

Conditions
ConditionsYield
With oxygen; trifluoroacetic acid In toluene Flow reactor; chemoselective reaction;A 81%
B 7%
4-chloro-3-nitrobenzoate
96-99-1

4-chloro-3-nitrobenzoate

7β-hydroxyartemisinin

7β-hydroxyartemisinin

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃; for 12h; Inert atmosphere;75%
4α-hydroperoxy-amorph-5-en-12-oic acid
85031-60-3

4α-hydroperoxy-amorph-5-en-12-oic acid

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

Conditions
ConditionsYield
With oxygen; copper(I) triflate at 20℃; Temperature;65%
(3R)-dihydroarteannuin B acid methyl carbonate
1267472-30-9

(3R)-dihydroarteannuin B acid methyl carbonate

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

Conditions
ConditionsYield
With oxygen; trifluoroacetic acid; 5,10,15,20-tetraphenyl-21H,23H-porphine In dichloromethane at -10 - 20℃; for 22h; Photochemical reaction;62.2%
(3R)-dihydroarteannuin B acid ethyl carbonate
1267472-33-2

(3R)-dihydroarteannuin B acid ethyl carbonate

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

Conditions
ConditionsYield
With oxygen; trifluoroacetic acid; 5,10,15,20-tetraphenyl-21H,23H-porphine In dichloromethane at -10 - 20℃; for 22h; Photochemical reaction;62%
With 5,10,15,20-tetraphenyl-21H,23H-porphine; trifluoroacetic acid In dichloromethane at -15 - -10℃; Irradiation; Industrial scale;370 kg
(3R)-dihydroarteannuin B acid benzyl carbonate
1267472-35-4

(3R)-dihydroarteannuin B acid benzyl carbonate

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

Conditions
ConditionsYield
With oxygen; trifluoroacetic acid; 5,10,15,20-tetraphenyl-21H,23H-porphine In dichloromethane at -10 - 20℃; for 22h; Photochemical reaction;59.2%
dihydroartemisinic acid
85031-59-0, 110715-68-9, 126643-10-5

dihydroartemisinic acid

A

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

B

arteanniun H
207446-83-1

arteanniun H

Conditions
ConditionsYield
Stage #1: dihydroartemisinic acid With oxygen; 5,15,10,20-tetraphenylporphyrin In dichloromethane Irradiation; High pressure;
Stage #2: With oxygen; trifluoroacetic acid In dichloromethane; toluene at 25℃; for 0.333333h;
A 59.1%
B 6.1%
Multi-step reaction with 2 steps
1: 5,15,10,20-tetraphenylporphyrin; oxygen / dichloromethane / -20 °C / Flow reactor; UV-irradiation
2: trifluoroacetic acid; oxygen / toluene / 0.33 h / 25 °C / 750.08 Torr / Flow reactor
View Scheme
Multi-step reaction with 2 steps
1: 5,15,10,20-tetraphenylporphyrin; oxygen / dichloromethane / -20 °C / Flow reactor; UV-irradiation
2: trifluoroacetic acid; oxygen / toluene / 0.33 h / 50 °C / 750.08 Torr / Flow reactor
View Scheme
Multi-step reaction with 2 steps
1: 5,15,10,20-tetraphenylporphyrin; oxygen / dichloromethane / 60 °C / Flow reactor; UV-irradiation
2: trifluoroacetic acid; oxygen / toluene / 0.33 h / 25 °C / 750.08 Torr / Flow reactor
View Scheme
Multi-step reaction with 2 steps
1: 5,15,10,20-tetraphenylporphyrin; oxygen / dichloromethane / 60 °C / Flow reactor; UV-irradiation
2: trifluoroacetic acid; oxygen / toluene / 0.33 h / 50 °C / 750.08 Torr / Flow reactor
View Scheme
(3R)-dihydroarteannuin B acid 2,2,2-trichloroethyl carbonate
1267472-31-0

(3R)-dihydroarteannuin B acid 2,2,2-trichloroethyl carbonate

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

Conditions
ConditionsYield
With oxygen; trifluoroacetic acid; 5,10,15,20-tetraphenyl-21H,23H-porphine In dichloromethane at -10 - 20℃; for 22h; Photochemical reaction;58.7%
(3R)-dihydroarteannuin B acid phenyl carbonate
1267472-37-6

(3R)-dihydroarteannuin B acid phenyl carbonate

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

Conditions
ConditionsYield
With oxygen; trifluoroacetic acid; 5,10,15,20-tetraphenyl-21H,23H-porphine In dichloromethane at -10 - 20℃; for 22h; Photochemical reaction;58.4%
dihydroartemisinic acid
85031-59-0, 110715-68-9, 126643-10-5

dihydroartemisinic acid

A

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

B

(4R,4aS,7R,8S)-4,7-Dimethyl-8-(3-oxo-butyl)-4,4a,5,6,7,8-hexahydro-isochromen-3-one
105231-07-0

(4R,4aS,7R,8S)-4,7-Dimethyl-8-(3-oxo-butyl)-4,4a,5,6,7,8-hexahydro-isochromen-3-one

Conditions
ConditionsYield
Stage #1: dihydroartemisinic acid With oxygen; 5,15,10,20-tetraphenylporphyrin In dichloromethane Irradiation; High pressure;
Stage #2: With oxygen; trifluoroacetic acid In dichloromethane; toluene at 0℃; for 1h; Solvent; Temperature; Time;
A 55.6%
B 6.8%
Stage #1: dihydroartemisinic acid With oxygen; 5,15,10,20-tetraphenylporphyrin In dichloromethane Irradiation; High pressure;
Stage #2: With oxygen; trifluoroacetic acid In dichloromethane; toluene at -15℃; for 0.333333h;
A 18%
B 21.3%
Multi-step reaction with 2 steps
1: 5,15,10,20-tetraphenylporphyrin; oxygen / dichloromethane / -20 °C / Flow reactor; UV-irradiation
2: trifluoroacetic acid; oxygen / toluene / 1 h / 0 °C / 750.08 Torr / Flow reactor
View Scheme
Multi-step reaction with 2 steps
1: 5,15,10,20-tetraphenylporphyrin; oxygen / dichloromethane / 60 °C / Flow reactor; UV-irradiation
2: trifluoroacetic acid; oxygen / toluene / 1 h / 0 °C / 750.08 Torr / Flow reactor
View Scheme
(3R)-dihydroarteannuin B acid 2-chloroethyl carbonate
1267472-43-4

(3R)-dihydroarteannuin B acid 2-chloroethyl carbonate

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

Conditions
ConditionsYield
With oxygen; trifluoroacetic acid; 5,10,15,20-tetraphenyl-21H,23H-porphine In dichloromethane at -10 - 20℃; for 22h; Photochemical reaction;54.9%
(3R)-dihydroarteannuin B acid propyl carbonate
1267472-39-8

(3R)-dihydroarteannuin B acid propyl carbonate

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

Conditions
ConditionsYield
With oxygen; trifluoroacetic acid; 5,10,15,20-tetraphenyl-21H,23H-porphine In dichloromethane at -10 - 20℃; for 22h; Photochemical reaction;54.5%
dihydroartemisinic acid
85031-59-0, 110715-68-9, 126643-10-5

dihydroartemisinic acid

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

Conditions
ConditionsYield
Stage #1: dihydroartemisinic acid With oxygen; 5,15,10,20-tetraphenylporphyrin In dichloromethane under 8625.86 Torr;
Stage #2: With oxygen; trifluoroacetic acid In dichloromethane at 0℃; for 2h;
50%
Stage #1: dihydroartemisinic acid With oxygen; 5,15,10,20-tetraphenylporphyrin In dichloromethane under 8625.86 Torr; UV-irradiation;
Stage #2: With oxygen; trifluoroacetic acid In dichloromethane at 0℃; under 760.051 Torr; for 2h; Pressure; Temperature; Solvent;
50%
Stage #1: dihydroartemisinic acid With oxygen; 5,15,10,20-tetraphenylporphyrin In dichloromethane at 0℃; under 760.051 Torr; for 0.0333333h;
Stage #2: With trifluoroacetic acid In dichloromethane at 0℃; for 2h; Time; Temperature; Concentration; UV-irradiation;
50%
dihydroartemisinic acid
85031-59-0, 110715-68-9, 126643-10-5

dihydroartemisinic acid

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

Conditions
ConditionsYield
With porphyrin; trifluoroacetic acid In toluene at 25℃; Temperature; Reagent/catalyst; Irradiation;50%
(+)-deoxoartemisinin
126189-95-5

(+)-deoxoartemisinin

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

Conditions
ConditionsYield
With ruthenium trichloride; sodium periodate49%
dihydroartemisinic acid
85031-59-0, 110715-68-9, 126643-10-5

dihydroartemisinic acid

A

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

B

(3R,3a,6R,6aS,10aS)-3a,4,5,6,6a,7,8,8a-octahydro-3,6,9-trimethylnaphtho[8a,1-b]furan-2(3H)-one
104196-16-9

(3R,3a,6R,6aS,10aS)-3a,4,5,6,6a,7,8,8a-octahydro-3,6,9-trimethylnaphtho[8a,1-b]furan-2(3H)-one

C

arteanniun H
207446-83-1

arteanniun H

Conditions
ConditionsYield
Stage #1: dihydroartemisinic acid With oxygen; 5,15,10,20-tetraphenylporphyrin In dichloromethane Irradiation; High pressure;
Stage #2: With oxygen; trifluoroacetic acid In dichloromethane; toluene at 50℃; for 0.333333h;
A 47%
B 5.5%
C 7.2%
5α-hydroperoxy-amorph-5-en-12-oic acid methyl ester
85031-63-6

5α-hydroperoxy-amorph-5-en-12-oic acid methyl ester

A

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

B

(R)-2-((4R,4aS)-4,7-Dimethyl-2,3,4,4a,5,6-hexahydro-naphthalen-1-yl)-propionic acid methyl ester

(R)-2-((4R,4aS)-4,7-Dimethyl-2,3,4,4a,5,6-hexahydro-naphthalen-1-yl)-propionic acid methyl ester

C

(R)-2-[(1S,3S,4R)-2-Formyl-2-[(2R,4aS,5R,8S)-8-((R)-1-methoxycarbonyl-ethyl)-2,5-dimethyl-2,3,4,4a,5,6,7,8-octahydro-naphthalen-2-ylperoxy]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester
422565-48-8

(R)-2-[(1S,3S,4R)-2-Formyl-2-[(2R,4aS,5R,8S)-8-((R)-1-methoxycarbonyl-ethyl)-2,5-dimethyl-2,3,4,4a,5,6,7,8-octahydro-naphthalen-2-ylperoxy]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester

D

(R)-2-[(1S,3S,4R)-2-Formyl-2-[(2S,3R,6S)-6-((R)-1-methoxycarbonyl-ethyl)-3-methyl-2-(3-oxo-butyl)-cyclohex-(E)-ylidenemethoxy]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester

(R)-2-[(1S,3S,4R)-2-Formyl-2-[(2S,3R,6S)-6-((R)-1-methoxycarbonyl-ethyl)-3-methyl-2-(3-oxo-butyl)-cyclohex-(E)-ylidenemethoxy]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester

Conditions
ConditionsYield
In chloroform-d1 for 2556.75h; Further byproducts given;A 3%
B 40%
C 4%
D n/a
dihydroartemisinic acid
85031-59-0, 110715-68-9, 126643-10-5

dihydroartemisinic acid

A

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

B

(3R,3a,6R,6aS,10aS)-3a,4,5,6,6a,7,8,8a-octahydro-3,6,9-trimethylnaphtho[8a,1-b]furan-2(3H)-one
104196-16-9

(3R,3a,6R,6aS,10aS)-3a,4,5,6,6a,7,8,8a-octahydro-3,6,9-trimethylnaphtho[8a,1-b]furan-2(3H)-one

C

(4R,4aS,7R,8S)-4,7-Dimethyl-8-(3-oxo-butyl)-4,4a,5,6,7,8-hexahydro-isochromen-3-one
105231-07-0

(4R,4aS,7R,8S)-4,7-Dimethyl-8-(3-oxo-butyl)-4,4a,5,6,7,8-hexahydro-isochromen-3-one

D

arteanniun H
207446-83-1

arteanniun H

Conditions
ConditionsYield
Stage #1: dihydroartemisinic acid With oxygen; 5,15,10,20-tetraphenylporphyrin In dichloromethane Irradiation; High pressure;
Stage #2: With oxygen; trifluoroacetic acid In dichloromethane; toluene at 75℃; for 0.333333h;
A 31.2%
B 6.1%
C 9.6%
D 7.5%
4-((7R,8S)-3-methoxy-4,7-dimethyl-3-((triisopropylsilyl)oxy)-4,4a,5,6,7,8-hexahydro-3H-isochromen-8-yl)butan-2-one
1393603-22-9

4-((7R,8S)-3-methoxy-4,7-dimethyl-3-((triisopropylsilyl)oxy)-4,4a,5,6,7,8-hexahydro-3H-isochromen-8-yl)butan-2-one

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

Conditions
ConditionsYield
Stage #1: 4-((7R,8S)-3-methoxy-4,7-dimethyl-3-((triisopropylsilyl)oxy)-4,4a,5,6,7,8-hexahydro-3H-isochromen-8-yl)butan-2-one With ammonium molibdate; dihydrogen peroxide In water; tert-butyl alcohol at 20℃; for 72h;
Stage #2: With toluene-4-sulfonic acid In dichloromethane at 20℃; for 72h;
29%
(R)-2-[(1S,3S,4R)-2-[1-Methoxy-meth-(Z)-ylidene]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester
87322-20-1

(R)-2-[(1S,3S,4R)-2-[1-Methoxy-meth-(Z)-ylidene]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

Conditions
ConditionsYield
Stage #1: (R)-2-[(1S,3S,4R)-2-[1-Methoxy-meth-(Z)-ylidene]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester With hydrogenchloride; oxygen; rose bengal In methanol at -78℃; for 4h; UV-irradiation;
Stage #2: With perchloric acid for 28h;
10%
dehydroqinghaosu
101020-89-7

dehydroqinghaosu

A

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

B

(+)-9-epiartemisinin
113472-97-2

(+)-9-epiartemisinin

C

9β-hydroxydeoxy-11-epi-artemisinin

9β-hydroxydeoxy-11-epi-artemisinin

D

9β-hydroxy-11-epi-artemisinin

9β-hydroxy-11-epi-artemisinin

Conditions
ConditionsYield
With Aspergillus niger NRRL 599; culture medium In water; acetone at 25℃; for 240h; Hydrogenation; oxidation; deoxygenation;A n/a
B 8.9%
C 5.5%
D 7.1%
artemisinic acid
80286-58-4

artemisinic acid

A

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

B

(1R,5S,8R,9S,12R,14R)-8,12-dimethyl-4-methylidene-2,13-dioxatetracyclo[7.5.0.01,5.012,14]tetradecan-3-one
50906-56-4

(1R,5S,8R,9S,12R,14R)-8,12-dimethyl-4-methylidene-2,13-dioxatetracyclo[7.5.0.01,5.012,14]tetradecan-3-one

Conditions
ConditionsYield
In water at 30℃; for 2h; cell-free extract from Artemisia annua L. (Asteraceae), EDTA, HEPES with DDT buffer, pH 7.15; Title compound not separated from byproducts;
(2R,1'S,3'S,4'S)-2-<4'-methyl-3'-(3''-oxobutyl)-2'(E)-<(trimethylsilyl)methylene>cyclohexyl>propionic acid
116399-93-0

(2R,1'S,3'S,4'S)-2-<4'-methyl-3'-(3''-oxobutyl)-2'(E)-<(trimethylsilyl)methylene>cyclohexyl>propionic acid

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

Conditions
ConditionsYield
With ozone; trifluoroacetic acid 1.) MeOH, -78 deg C, 2.) CHCl3, H2O; Yield given. Multistep reaction;
(2R,1'S,3'S,4'S)-2-<4'-methyl-3'-(3''-oxobutyl)-2'(E)-<(trimethylsilyl)methylene>cyclohexyl>propionic acid
116399-93-0

(2R,1'S,3'S,4'S)-2-<4'-methyl-3'-(3''-oxobutyl)-2'(E)-<(trimethylsilyl)methylene>cyclohexyl>propionic acid

A

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

B

2-deoxyartemisinin
72826-63-2

2-deoxyartemisinin

Conditions
ConditionsYield
With oxygen; ozone; trifluoroacetic acid 1.) CH2Cl2, -78 deg C, 2.) CDCl3; Yield given. Multistep reaction. Yields of byproduct given;
2,5,5-trimethyl-2-<2'-<4''-(1(S)-carboxyethyl)-1''(R)-methyl-3''-<(trimethylsilyl)methylene>cyclohex-2''-yl>ethyl>-1,3-dioxane
116400-02-3

2,5,5-trimethyl-2-<2'-<4''-(1(S)-carboxyethyl)-1''(R)-methyl-3''-<(trimethylsilyl)methylene>cyclohex-2''-yl>ethyl>-1,3-dioxane

A

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

B

2-deoxyartemisinin
72826-63-2

2-deoxyartemisinin

Conditions
ConditionsYield
With 2,6-di-tert-butyl-4-methyl-phenol; sulfuric acid; oxygen; silica gel; ozone 1.) CH2Cl2, -78 deg C, 2 min, 2.) CH2Cl2, 22 deg C, overnight; Yield given. Multistep reaction. Yields of byproduct given;
Sodium; (R)-2-[(1S,3S,4R)-2-[1-methoxy-meth-(Z)-ylidene]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionate

Sodium; (R)-2-[(1S,3S,4R)-2-[1-methoxy-meth-(Z)-ylidene]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionate

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

Conditions
ConditionsYield
With formic acid; oxygen 1.) MeOH, irradiation, -78 ded C, 2.) CH2Cl2, 0 deg C, 24 h; Yield given;
Benzoic acid (2R,4aR,5R,8R,8aS)-5-((R)-1-methoxycarbonyl-ethyl)-3,8-dimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-2-yl ester

Benzoic acid (2R,4aR,5R,8R,8aS)-5-((R)-1-methoxycarbonyl-ethyl)-3,8-dimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-2-yl ester

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

Conditions
ConditionsYield
Yield given. Multistep reaction;
C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

dihydroartemisinin
71939-50-9

dihydroartemisinin

Conditions
ConditionsYield
With diisobutylaluminium hydride In dichloromethane at -78℃; for 1.25h;100%
With methanol; sodium tetrahydroborate at 0℃; for 3h; Inert atmosphere;100%
With sodium tetrahydroborate In methanol at 0 - 20℃; for 0.5h; Inert atmosphere; Green chemistry;98%
With sodium tetrahydroborate In methanol at 0℃; for 1h;91%
With sodium tetrahydroborate In methanol at 0 - 5℃; for 3h;79%
C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

dihydroartesiminin
81496-81-3

dihydroartesiminin

Conditions
ConditionsYield
With sodium tetrahydroborate; N-benzyl-N,N,N-triethylammonium chloride In water; toluene at -10 - 0℃; for 5h; Solvent; Inert atmosphere; Large scale;99.6%
With sodium tetrahydroborate In methanol at 0℃;
With diisobutylaluminium hydride at -78℃;
C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

dihydroartemisinin
71939-50-9

dihydroartemisinin

Conditions
ConditionsYield
With methanol; sodium tetrahydroborate at 0℃; for 3h;98%
With sodium tetrahydroborate In methanol at 0 - 5℃; for 3.33333h;97.15%
With sodium tetrahydroborate In methanol for 1.25h;96%
C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

2-deoxyartemisinin
72826-63-2

2-deoxyartemisinin

Conditions
ConditionsYield
With zinc In acetic acid for 2.5h; Ambient temperature;98%
With hydrogen; Lindlar's catalyst In methanol for 10h;88%
With hydrogen; Lindlar's catalyst In methanol Ambient temperature;86%
succinic acid anhydride
108-30-5

succinic acid anhydride

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

artesunate
88495-63-0

artesunate

Conditions
ConditionsYield
Stage #1: C12H13O2(CH3)3(O)(OO) With sodium tetrahydroborate; cation exchange resin In tetrahydrofuran at 20 - 35℃; for 0.666667h;
Stage #2: succinic acid anhydride With triethylamine In tetrahydrofuran at 20 - 35℃; for 1h;
96%
Stage #1: C12H13O2(CH3)3(O)(OO) With sodium tetrahydroborate; D-glucose In 1,4-dioxane at 20 - 30℃; for 2h;
Stage #2: succinic acid anhydride In 1,4-dioxane at 20 - 30℃; for 2h;
93%
Stage #1: C12H13O2(CH3)3(O)(OO) With sodium tetrahydroborate; cation exchange resin In tetrahydrofuran at 20 - 35℃; for 0.75h;
Stage #2: succinic acid anhydride With sodium hydrogencarbonate In tetrahydrofuran at 20 - 35℃; for 1.25h;
93%
C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

7β-hydroxyartemisinin

7β-hydroxyartemisinin

Conditions
ConditionsYield
With sodium phosphite; phosphite dehydrogenase; P450 variant IV-H4; oxygen; nicotinamide adenine dinucleotide phosphate In aq. phosphate buffer at 20℃; for 12h; pH=8; Reagent/catalyst; Time;92%
C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

9α-hydroxyartemisinin

9α-hydroxyartemisinin

Conditions
ConditionsYield
With sodium phosphite; phosphite dehydrogenase; P450 variant II-H10; oxygen; nicotinamide adenine dinucleotide phosphate In aq. phosphate buffer at 20℃; for 12h; pH=8;91%
methanol
67-56-1

methanol

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

A

(R)-2-((1R,4S,4aR,7R,9aS)-4a-Formyl-7-hydroxy-1,7-dimethyl-octahydro-5,6-dioxa-benzocyclohepten-4-yl)-propionic acid methyl ester
95851-77-7

(R)-2-((1R,4S,4aR,7R,9aS)-4a-Formyl-7-hydroxy-1,7-dimethyl-octahydro-5,6-dioxa-benzocyclohepten-4-yl)-propionic acid methyl ester

B

(R)-2-[(1S,3S,4R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester
103740-01-8

(R)-2-[(1S,3S,4R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester

Conditions
ConditionsYield
With sulfuric acid for 0.166667h;A n/a
B 90%
C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

acetyl chloride
75-36-5

acetyl chloride

dihydroartemisinin acetate
75887-51-3

dihydroartemisinin acetate

Conditions
ConditionsYield
Stage #1: C12H13O2(CH3)3(O)(OO) With sodium tetrahydroborate
Stage #2: acetyl chloride With pyridine
90%
C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

6a-hydroxy-artemisinin

6a-hydroxy-artemisinin

Conditions
ConditionsYield
With sodium phosphite; phosphite dehydrogenase; P450 variant X-F11; oxygen; nicotinamide adenine dinucleotide phosphate In aq. phosphate buffer at 20℃; for 12h; pH=8; Reagent/catalyst; Time;90%
dehydroqinghaosu
101020-89-7

dehydroqinghaosu

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

C30H42O10

C30H42O10

Conditions
ConditionsYield
Stage #1: C12H13O2(CH3)3(O)(OO) With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.75h;
Stage #2: dehydroqinghaosu In tetrahydrofuran at -78℃; for 5h; Further stages.;
88%
C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

(trifluoromethyl)trimethylsilane
81290-20-2

(trifluoromethyl)trimethylsilane

(1S,4R,5R,8R,9R,10R,12R,13R)-1,5,9-trimethyl-10-(trifluoromethyl)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol
185418-56-8

(1S,4R,5R,8R,9R,10R,12R,13R)-1,5,9-trimethyl-10-(trifluoromethyl)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran for 25h; Ambient temperature;87%
C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

A

(3aS,4R,6aS,7R,10S,10aR)-10-(acetyloxy)octahydro-4,7-dimethyl-8H,10H-furo[3,2-i][2]benzopyran-8-one
98379-74-9

(3aS,4R,6aS,7R,10S,10aR)-10-(acetyloxy)octahydro-4,7-dimethyl-8H,10H-furo[3,2-i][2]benzopyran-8-one

B

(3R,3aS,6R,6aS,8R,9S,10aS,10bR)-octahydro-8-hydroxy-3,6,9-trimethyl-10aH-9,10b-epoxypyrano[4,3,2-jk][2]benzoxepin-2(3H)-one

(3R,3aS,6R,6aS,8R,9S,10aS,10bR)-octahydro-8-hydroxy-3,6,9-trimethyl-10aH-9,10b-epoxypyrano[4,3,2-jk][2]benzoxepin-2(3H)-one

Conditions
ConditionsYield
With pyridine; iron(III) chloride In acetonitrile for 36h;A 85%
B 8%
With meso-tetraphenylporphyrin iron(III) chloride; N-acetylcystein In dichloromethane for 0.75h;A 74%
B n/a
With 1H-imidazole; iron(III) trifluoromethanesulfonate; N-acetylcystein In acetonitrile for 18h;A 41%
B 50%
C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

9-fluoroartemisinin
1037585-91-3

9-fluoroartemisinin

Conditions
ConditionsYield
Stage #1: C12H13O2(CH3)3(O)(OO) With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1h;
Stage #2: With N-fluorobenzene sulfonamide In tetrahydrofuran at -78℃; for 1h; Further stages.;
85%
C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

allyl halogenide

allyl halogenide

(3R,6R,9S,12S,12aR)-9-allyl-3,6,9-trimethyloctahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one

(3R,6R,9S,12S,12aR)-9-allyl-3,6,9-trimethyloctahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one

Conditions
ConditionsYield
Stage #1: C12H13O2(CH3)3(O)(OO) With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere;
Stage #2: With N,N,N,N,N,N-hexamethylphosphoric triamide In tetrahydrofuran; hexane at -78℃; Inert atmosphere;
Stage #3: allyl halogenide With diethylzinc In tetrahydrofuran; hexane at -78 - 20℃; Inert atmosphere;
82%
C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

(trifluoromethyl)trimethylsilane
81290-20-2

(trifluoromethyl)trimethylsilane

trimethylsilyl (1S,4R,5R,8R,9R,10R,12S,13R)-1,5,9-trimethyl-10-(trifluoromethyl)-11,14,15,16-tetraoxatetracyclo[10.3.1.0.4,1308,13]hexadec-10-yl ether
405261-71-4

trimethylsilyl (1S,4R,5R,8R,9R,10R,12S,13R)-1,5,9-trimethyl-10-(trifluoromethyl)-11,14,15,16-tetraoxatetracyclo[10.3.1.0.4,1308,13]hexadec-10-yl ether

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 0 - 20℃; for 7h;79%
propan-1-ol
71-23-8

propan-1-ol

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

C18H30O5

C18H30O5

Conditions
ConditionsYield
Stage #1: C12H13O2(CH3)3(O)(OO) With sodium tetrahydroborate; amberlyst-15 In tetrahydrofuran at 20℃; for 0.5h;
Stage #2: propan-1-ol In dichloromethane at 20℃; for 72h;
79%
C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

A

(3aS,4R,6aS,7R,10S,10aR)-10-(acetyloxy)octahydro-4,7-dimethyl-8H,10H-furo[3,2-i][2]benzopyran-8-one
98379-74-9

(3aS,4R,6aS,7R,10S,10aR)-10-(acetyloxy)octahydro-4,7-dimethyl-8H,10H-furo[3,2-i][2]benzopyran-8-one

B

3α-hydroxydeoxyartemisinin

3α-hydroxydeoxyartemisinin

Conditions
ConditionsYield
With iron(II) chloride In acetonitrile for 0.0333333h; Mechanism; Ambient temperature;A 78%
B 17%
With iron(II) chloride In acetonitrile for 0.25h; Ambient temperature;A 78%
B 17%
C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

2-deuteriodihydroqinghaosu

2-deuteriodihydroqinghaosu

Conditions
ConditionsYield
With sodium borodeuteride In methanol for 1h; Reduction;77%
C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

(trifluoromethyl)trimethylsilane
81290-20-2

(trifluoromethyl)trimethylsilane

C16H23F3O5

C16H23F3O5

Conditions
ConditionsYield
Stage #1: C12H13O2(CH3)3(O)(OO); (trifluoromethyl)trimethylsilane With tetrabutyl ammonium fluoride In tetrahydrofuran at 0℃; for 2h;
Stage #2: With water at 20℃; for 0.5h; Further stages.;
77%
C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

(R)-2-[(1S,3S,4R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester
103740-01-8

(R)-2-[(1S,3S,4R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester

Conditions
ConditionsYield
With sulfuric acid In methanol75%
With iron(III) chloride In diethyl ether for 1.5h;
With trifluoroacetic acid In methanol Heating;
C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

10-deoxoartemisinin

10-deoxoartemisinin

Conditions
ConditionsYield
With sodium tetrahydroborate; boron trifluoride diethyl etherate In tetrahydrofuran75%
Multi-step reaction with 2 steps
1: 100 percent / DIBAL-H / CH2Cl2 / 1.25 h / -78 °C
2: 1.) Et3SiH, 2.) BF3*OEt2 / 1.) CH2Cl2, -78 deg C, 10 min, 2.) CH2Cl2, -78 deg C, 3 h
View Scheme
pentan-1-ol
71-41-0

pentan-1-ol

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

C20H34O5

C20H34O5

Conditions
ConditionsYield
Stage #1: C12H13O2(CH3)3(O)(OO) With sodium tetrahydroborate; amberlyst-15 In tetrahydrofuran at 20℃; for 0.5h;
Stage #2: pentan-1-ol In dichloromethane at 20℃; for 56h;
74%
C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

ethylene glycol
107-21-1

ethylene glycol

C18H30O6

C18H30O6

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In benzene for 17h; Reflux;74%
methanol
67-56-1

methanol

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

(R)-methyl 2-((3R,6R,9aR)-9a-formyl-3-methoxy-3,6-dimethyloctahydro-3H-benzo[c][1,2]dioxepin-9-yl)propanoate
95851-75-5

(R)-methyl 2-((3R,6R,9aR)-9a-formyl-3-methoxy-3,6-dimethyloctahydro-3H-benzo[c][1,2]dioxepin-9-yl)propanoate

Conditions
ConditionsYield
With trifluoroacetic acid for 5h; Reflux;73%
With sulfuric acid for 3h; Yield given;
Butane-1,4-diol
110-63-4

Butane-1,4-diol

C12H13O2(CH3)3(O)(OO)
63968-64-9

C12H13O2(CH3)3(O)(OO)

C19H32O6

C19H32O6

Conditions
ConditionsYield
Stage #1: C12H13O2(CH3)3(O)(OO) With sodium tetrahydroborate; amberlyst-15 In tetrahydrofuran at 20℃; for 0.5h;
Stage #2: Butane-1,4-diol In dichloromethane at 20℃; for 55h;
73%
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