Products

Refine

Country

Business Type

Certificate

Display

Yangzhou Qinyuan Pharmatech Co.,Ltd

Cas no. 641571-11-1 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Nilotinib Intermediates Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Cas:641571-11-1

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Hangzhou Maytime Bio-Tech Co.,Ltd.

We are Top supplier for below nilotinib intermediates 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid 641569-94-0 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

High quality Nilotinib intermediate CAS:641571-11-1

Cas:641571-11-1

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou Johoo Chemical Co., Ltd

High quality products. Always supply highest grade to you. Purity:≥98% Reasonable & Competitive Price. Huge capacity determines the lowest shared cost. The more you buy the more competitive prices you will get. The sincerest and most pro

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Manufacturer/High quality/Best price/In stock

Cas:641571-11-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance Off-white to brown powder Off-white powder Identification H

High purity Various Specifications 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline CAS:641571-11-1

Cas:641571-11-1

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 3-(4-Methyl-1H-Imidazol-1-Yl)-5-(Trifluoromethyl)Aniline supplier in China

Cas:641571-11-1

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Nanjing Yuance Industry&Trade Co., Ltd.

Purity 99% with good quality Competitive price Fast delivery Appearance:Powder or liquid Storage:Store in cool dry place Package:25 kg/drum Application:Pharmaceutical intermediates Port:Shanghai, Nanjing

3-(trifluoromethyl)-5-(4-methyl-1H-imidazol-1-yl)benzenamine

Cas:641571-11-1

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hangzhou Think Chemical Co. Ltd

Nilotinib Intermediate 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline[CAS:641571-11-1] HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline for Nilotinib

Cas:641571-11-1

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality Oled CAS 641571-11-1 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Cas:641571-11-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Cas:641571-11-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-aniline

Cas:641571-11-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

High quality Nilotinib intermediate CAS:641571-11-1

Cas:641571-11-1

Min.Order:1 Kilogram

FOB Price: $400.0

Type:Trading Company

inquiry

Hubei DiBo chemical co., LTD

Name:3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline CAS:641571-11-1 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

high quality 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Cas:641571-11-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Cas:641571-11-1

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Cas:641571-11-1

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 641571-11-1 with competitive price

Cas:641571-11-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline CAS:641571-11-1

Cas:641571-11-1

Min.Order:1 Kilogram

FOB Price: $38.0 / 59.0

Type:Trading Company

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product Name 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline CAS No. 641571-11-1

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Cas:641571-11-1

Min.Order:1 Gram

FOB Price: $6.0

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline CAS NO 641571-11-1

Cas:641571-11-1

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 641571-11-1

Cas:641571-11-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline CAS: 641571-11-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, spe

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline CAS: 641571-11-1

Cas:641571-11-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Cas:641571-11-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:641571-11-1

Cas:641571-11-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

3-(4-Methyl-1H-Imidazol-1-Yl)-5-(Trifluoromethyl)Aniline

Cas:641571-11-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TIANFUCHEM-- 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Cas:641571-11-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Appearance:almost white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Cas:641571-11-1

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Cas:641571-11-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS641571-11-1 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Cas:641571-11-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

4-methyl-1H-imidazole
822-36-6

4-methyl-1H-imidazole

[3-bromo-5-(trifluoromethyl)phenyl]amine
54962-75-3

[3-bromo-5-(trifluoromethyl)phenyl]amine

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
With copper(l) iodide; (+)-D-glucosamine hydrochloride; caesium carbonate In water; dimethyl sulfoxide at 90℃; for 12h; Temperature; Concentration;96.18%
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) In toluene; tert-butyl alcohol at 120℃; for 8h; Inert atmosphere;91%
With copper(l) iodide; 1-(5,6,7,8-tetrahydroquinolin-8-yl)ethan-1-one; caesium carbonate In N,N-dimethyl-formamide at 110℃; for 18h; Inert atmosphere; Sealed tube;91%
C23H18F6N6O

C23H18F6N6O

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
With sodium hydroxide In m-xylene; isopropyl alcohol for 25h; Reflux;92.8%
4-methyl-1-(3-nitro-5-(trifluoromethyl)phenyl)-1H-imidazole
916975-92-3

4-methyl-1-(3-nitro-5-(trifluoromethyl)phenyl)-1H-imidazole

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
With iron(III) chloride; hydrazine hydrate; pyrographite In ethanol at 50 - 60℃; Reagent/catalyst; Temperature;91.3%
With palladium In methanol at 25℃; for 5h;86%
With palladium on activated charcoal; hydrogen In methanol at 25℃; for 5h;86%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzohydrazide

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzohydrazide

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
Stage #1: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzohydrazide With sulfuric acid; sodium nitrite In methanol at 15 - 25℃; for 0.416667h;
Stage #2: In methanol at 55 - 75℃; for 0.416667h; Concentration; Reagent/catalyst; Temperature;
90%
N-(3-amino-5-(trifluoromethyl)phenyl)acetamide
455279-96-6

N-(3-amino-5-(trifluoromethyl)phenyl)acetamide

formaldehyd
50-00-0

formaldehyd

2-oxopropanal
78-98-8

2-oxopropanal

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
Stage #1: N-(3-amino-5-(trifluoromethyl)phenyl)acetamide With ammonium chloride In ethanol; acetone at 0 - 20℃;
Stage #2: formaldehyd; 2-oxopropanal In ethanol; water; acetone at 65 - 70℃;
85.4%
3-(4-methyl-imidazol-1-yl)-5-trifluoromethylbenzoic acid
641571-13-3

3-(4-methyl-imidazol-1-yl)-5-trifluoromethylbenzoic acid

tert-butyl alcohol
75-65-0

tert-butyl alcohol

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
Stage #1: 3-(4-methyl-imidazol-1-yl)-5-trifluoromethylbenzoic acid; tert-butyl alcohol With diphenyl phosphoryl azide; triethylamine for 16h; Reflux;
Stage #2: With sodium hydroxide In propan-1-ol; para-xylene; water for 30h; Solvent; Reagent/catalyst; Reflux;
79.5%
N-(4-methoxybenzyl)-3-(4-methyl-1H-imidazol-1yl)-5-trifluoromethylaniline

N-(4-methoxybenzyl)-3-(4-methyl-1H-imidazol-1yl)-5-trifluoromethylaniline

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
With trifluoroacetic acid at 20 - 25℃; for 2h; Reagent/catalyst; Temperature;78%
4-methyl-1H-imidazole
822-36-6

4-methyl-1H-imidazole

3-iodo-5-trifluoromethylaniline
389571-69-1

3-iodo-5-trifluoromethylaniline

A

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

B

3-(5-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

3-(5-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
With potassium phosphate at 110℃; for 30h; Reagent/catalyst;A 65.2%
B n/a
4-methyl-1H-imidazole
822-36-6

4-methyl-1H-imidazole

[3-bromo-5-(trifluoromethyl)phenyl]amine
54962-75-3

[3-bromo-5-(trifluoromethyl)phenyl]amine

A

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

B

3-(5-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

3-(5-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
With copper(l) iodide; caesium carbonate; rac-diaminocyclohexane In diethylene glycol dimethyl ether at 24℃; for 24h; Reagent/catalyst; Inert atmosphere;A 64.9%
B n/a
With copper(I) oxide; potassium phosphate; N1,N2-bis(furan-2-ylmethyl)oxalamide In dimethyl sulfoxide at 120℃; for 24h; Overall yield = 89 %;
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline hydrochloride
917391-26-5

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline hydrochloride

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
With potassium hydrogencarbonate In ethanol; water at 0 - 45℃; for 3.5h; Product distribution / selectivity;32.8%
With potassium hydrogencarbonate In methanol; water at 20 - 40℃; for 3h; Product distribution / selectivity;
N-(3-(4-methyl-1H-1-imidazolyl)-5-trifluoromethylbenzene) tert-butoxycarbonylamine

N-(3-(4-methyl-1H-1-imidazolyl)-5-trifluoromethylbenzene) tert-butoxycarbonylamine

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
Stage #1: N-(3-(4-methyl-1H-1-imidazolyl)-5-trifluoromethylbenzene) tert-butoxycarbonylamine With hydrogenchloride In isopropyl alcohol at 60℃; for 5h;
Stage #2: With sodium hydrogencarbonate In water; isopropyl alcohol
4-methyl-1H-imidazole
822-36-6

4-methyl-1H-imidazole

3-fluoro-5-trifluoromethylaniline
454-67-1

3-fluoro-5-trifluoromethylaniline

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
Stage #1: 4-methyl-1H-imidazole With sodium hydride In tetrahydrofuran at 20 - 25℃; for 0.25h;
Stage #2: 3-fluoro-5-trifluoromethylaniline In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 20 - 165℃; for 22.25h; Product distribution / selectivity;
1-fluoro-3-(trifluoromethyl)-5-nitrobenzene
454-73-9

1-fluoro-3-(trifluoromethyl)-5-nitrobenzene

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: caesium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C
2: palladium / methanol / 5 h / 25 °C
View Scheme
Multi-step reaction with 2 steps
1: caesium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C
2: palladium on activated charcoal; hydrogen / methanol / 5 h / 25 °C
View Scheme
Multi-step reaction with 2 steps
1: caesium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C
2: palladium on activated charcoal; hydrogen / methanol / 5 h / 25 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate
2: tin(ll) chloride; hydrogenchloride / water
View Scheme
α,α,α-trifluorotoluene
98-08-8

α,α,α-trifluorotoluene

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: nitric acid; sulfuric acid / 2 h / 40 °C
2: nitric acid; sulfuric acid; bromine / 4 h / 70 °C
3: iron; hydrogenchloride / ethanol / 1.5 h / 40 °C
4: D-glucosamine hydrochloride; copper(l) iodide; caesium carbonate / dimethyl sulfoxide; water / 10 h / 100 °C
View Scheme
Multi-step reaction with 4 steps
1: nitric acid; sulfuric acid / 8 h / 0 - 20 °C
2: sulfuric acid; bromine / 14 h / 60 - 70 °C / Cooling with ice
3: potassium carbonate; triethylamine; copper(l) iodide; isoquinolin-8-ol / N,N-dimethyl-formamide / 5 h / 100 - 140 °C
4: iron(III) chloride; pyrographite; hydrazine hydrate / ethanol / 50 - 60 °C
View Scheme
3-trifluoromethylnitrobenzene
98-46-4

3-trifluoromethylnitrobenzene

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: nitric acid; sulfuric acid; bromine / 4 h / 70 °C
2: iron; hydrogenchloride / ethanol / 1.5 h / 40 °C
3: D-glucosamine hydrochloride; copper(l) iodide; caesium carbonate / dimethyl sulfoxide; water / 10 h / 100 °C
View Scheme
Multi-step reaction with 3 steps
1: sulfuric acid; bromine / 14 h / 60 - 70 °C / Cooling with ice
2: potassium carbonate; triethylamine; copper(l) iodide; isoquinolin-8-ol / N,N-dimethyl-formamide / 5 h / 100 - 140 °C
3: iron(III) chloride; pyrographite; hydrazine hydrate / ethanol / 50 - 60 °C
View Scheme
[3-bromo-5-(trifluoromethyl)phenyl]amine
54962-75-3

[3-bromo-5-(trifluoromethyl)phenyl]amine

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: N-ethyl-N,N-diisopropylamine; dmap / toluene
1.2: 5 h
2.1: trifluoroacetic acid / 2 h / 20 - 25 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium cyanoborohydride / tetrahydrofuran / 24 h / 20 °C
2.1: 8-quinolinol; 1-methyl-pyrrolidin-2-one / water / Inert atmosphere
2.2: 5 h / 140 - 145 °C / Inert atmosphere
3.1: trifluoroacetic acid / 2 h / 20 - 25 °C
View Scheme
ethyl 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoate

ethyl 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoate

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrazine hydrate / ethanol / 16 h / 78 °C
2.1: sodium nitrite; sulfuric acid / methanol / 0.42 h / 15 - 25 °C
2.2: 0.42 h / 55 - 75 °C
View Scheme
sodium 3-bromo-5-trifluoromethylbenzoate

sodium 3-bromo-5-trifluoromethylbenzoate

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; copper(l) iodide / N,N-dimethyl-formamide / 60 h / 115 °C / Molecular sieve
1.2: 30 - 35 °C / Molecular sieve
2.1: hydrazine hydrate / ethanol / 16 h / 78 °C
3.1: sodium nitrite; sulfuric acid / methanol / 0.42 h / 15 - 25 °C
3.2: 0.42 h / 55 - 75 °C
View Scheme
3-bromo-5-(trifluoromethyl)benzoic acid
328-67-6

3-bromo-5-(trifluoromethyl)benzoic acid

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; copper(l) iodide / N,N-dimethyl-formamide / 72 h / 115 °C / Molecular sieve
1.2: Molecular sieve
2.1: hydrazine hydrate / methanol / 16 h / 65 °C
3.1: sodium nitrite; sulfuric acid / methanol / 0.42 h / 15 - 25 °C
3.2: 0.42 h / 55 - 75 °C
View Scheme
Multi-step reaction with 3 steps
1.1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; copper(l) iodide / 1,4-dioxane / 72 h / 115 °C / Molecular sieve
2.1: hydrazine hydrate / methanol / 16 h / 65 °C
3.1: sodium nitrite; sulfuric acid / methanol / 0.42 h / 15 - 25 °C
3.2: 0.42 h / 55 - 75 °C
View Scheme
3-(4-methyl-imidazol-1-yl)-5-trifluoromethylbenzoic acid
641571-13-3

3-(4-methyl-imidazol-1-yl)-5-trifluoromethylbenzoic acid

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrazine hydrate / methanol / 16 h / 65 °C
2.1: sodium nitrite; sulfuric acid / methanol / 0.42 h / 15 - 25 °C
2.2: 0.42 h / 55 - 75 °C
View Scheme
3-bromo-5-trifluoromethylbenzoic acid methyl ester

3-bromo-5-trifluoromethylbenzoic acid methyl ester

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; copper(l) iodide / N,N-dimethyl-formamide / 105 °C / Molecular sieve
2.1: hydrazine hydrate / methanol / 16 h / 65 °C
3.1: sodium nitrite; sulfuric acid / methanol / 0.42 h / 15 - 25 °C
3.2: 0.42 h / 55 - 75 °C
View Scheme
3-fluoro-5-trifluoromethyl-benzonitrile
149793-69-1

3-fluoro-5-trifluoromethyl-benzonitrile

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide; water / 1.5 h / 25 - 35 °C
2.1: sodium amide / N,N-dimethyl acetamide / 1 h / 25 - 35 °C
2.2: 12 h / 25 - 85 °C
3.1: sodium hydroxide; bromine / water / 3.33 h / 0 - 95 °C
View Scheme
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzamide
917391-28-7

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzamide

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
With bromine; sodium hydroxide In water at 0 - 95℃; for 3.33333h;80 g
3-bromo-5-fluorobenzotrifluoride
130723-13-6

3-bromo-5-fluorobenzotrifluoride

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydride / 1-methyl-pyrrolidin-2-one
2: palladium diacetate / toluene
3: hydrogenchloride / water
View Scheme
1-[3-bromo-5-(trifluoromethyl)phenyl]-4-methyl-1H-imidazole
917391-27-6

1-[3-bromo-5-(trifluoromethyl)phenyl]-4-methyl-1H-imidazole

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium diacetate / toluene
2: hydrogenchloride / water
View Scheme
C24H18F3N3

C24H18F3N3

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
With hydrogenchloride In water
5-(trifluoromethyl)benzene-1,3-diamine
368-53-6

5-(trifluoromethyl)benzene-1,3-diamine

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: N-ethyl-N,N-diisopropylamine / toluene / 0 - 10 °C
2.1: ammonium chloride / ethanol; acetone / 0 - 20 °C
2.2: 65 - 70 °C
View Scheme
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 0 - 10 °C
2.1: ammonium chloride / ethanol; acetone / 0 - 20 °C
2.2: 65 - 70 °C
View Scheme
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

carbon monoxide
201230-82-2

carbon monoxide

5-bromo-2-methylphenyl(4-(pyridin-3-yl)pyrimidin-2-yl)-carbamic acid tert-butyl ester

5-bromo-2-methylphenyl(4-(pyridin-3-yl)pyrimidin-2-yl)-carbamic acid tert-butyl ester

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
Stage #1: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline; carbon monoxide; 5-bromo-2-methylphenyl(4-(pyridin-3-yl)pyrimidin-2-yl)-carbamic acid tert-butyl ester With bis(benzonitrile)palladium(II) dichloride; triethylamine; 1,2-bis-(diphenylphosphino)ethane; phenol In N,N-dimethyl-formamide at 90 - 105℃; under 6000.6 Torr; for 48h; Molecular sieve; Inert atmosphere; Autoclave;
Stage #2: With trifluoroacetic acid In ethanol Inert atmosphere;
Stage #3: With potassium hydroxide In ethanol; water pH=6 - 9; Reagent/catalyst; Solvent; Pressure; Inert atmosphere;
100%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

3-acetylamino-4-methylbenzoic acid
6946-14-1

3-acetylamino-4-methylbenzoic acid

3-acetamido-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-trifluoromethylphenyl]benzamide

3-acetamido-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-trifluoromethylphenyl]benzamide

Conditions
ConditionsYield
Stage #1: 3-acetylamino-4-methylbenzoic acid With thionyl chloride In dichloromethane for 4h; Reflux;
Stage #2: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline With triethylamine; aniline In dichloromethane for 8h; Reflux;
95.1%
Stage #1: 3-acetylamino-4-methylbenzoic acid With thionyl chloride In dichloromethane for 4h; Reflux;
Stage #2: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline With triethylamine In dichloromethane for 8h; Reflux;
94.7%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

3-((tert-butoxycarbonyl)amino)-4-methylbenzoic acid methyl ester
330807-44-8

3-((tert-butoxycarbonyl)amino)-4-methylbenzoic acid methyl ester

N-(2-methyl-5-((3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamoyl)phenyl)carbamic acid tert-butyl ester

N-(2-methyl-5-((3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamoyl)phenyl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at -10 - 0℃; Reagent/catalyst; Solvent; Temperature;95%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoic acid
641569-94-0

4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoic acid

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
Stage #1: 4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid With thionyl chloride In 1-methyl-pyrrolidin-2-one at 60℃; for 1.25h;
Stage #2: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline In 1-methyl-pyrrolidin-2-one at 90℃; for 3h; Product distribution / selectivity;
94%
Stage #1: 4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid With thionyl chloride In 1-methyl-pyrrolidin-2-one at 60℃; for 1.25h;
Stage #2: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline In 1-methyl-pyrrolidin-2-one at 90℃; for 3h;
Stage #3: With sodium hydroxide In 1-methyl-pyrrolidin-2-one; water at 80℃; pH=11 - 12; Product distribution / selectivity;
94%
Stage #1: 4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid With thionyl chloride In 1-methyl-pyrrolidin-2-one at 60℃; for 1.5h;
Stage #2: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline In 1-methyl-pyrrolidin-2-one at 90℃; for 0.5h;
90%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)azide

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)azide

Conditions
ConditionsYield
Stage #1: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 1.5h;
Stage #2: With sodium azide In water at 0 - 5℃; for 3h;
93.73%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

C17H13ClN4O

C17H13ClN4O

4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyridin-2-yl)pyrimidin-2-yl)amino)benzamide

4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyridin-2-yl)pyrimidin-2-yl)amino)benzamide

Conditions
ConditionsYield
Stage #1: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline; C17H13ClN4O In 1-methyl-pyrrolidin-2-one at 60℃; for 3h;
Stage #2: With potassium hydroxide In 1-methyl-pyrrolidin-2-one; water at 80℃;
Stage #3: With potassium carbonate In 1-methyl-pyrrolidin-2-one; water at 40 - 60℃; for 2h; Solvent;
93%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

methyl 3-azido-4-methylbenzoate
855304-57-3

methyl 3-azido-4-methylbenzoate

3-azido-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide
1408000-52-1

3-azido-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at -20 - 20℃;92%
With potassium tert-butylate In tetrahydrofuran at -20 - 20℃;92%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester

4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
With trimethylaluminum In toluene for 5h; Concentration; Time; Reflux;91%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

acetyl chloride
75-36-5

acetyl chloride

N-[3-(4-methyl-1H-1-imidazolyl)-5-trifluoromethylbenzene]acetamide

N-[3-(4-methyl-1H-1-imidazolyl)-5-trifluoromethylbenzene]acetamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 35℃; for 2h;90.1%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

methyl 4-methyl-3 -[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate
917392-54-2

methyl 4-methyl-3 -[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 0 - 20℃; for 12h; Inert atmosphere;90%
With sodium t-butanolate In tetrahydrofuran at 0 - 20℃; for 12h; Inert atmosphere;81%
With potassium tert-butylate In tetrahydrofuran at -5 - 20℃; for 30h; Inert atmosphere; Large scale;68%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

N-(3-(4-methyl-1H-1-imidazolyl)-5-trifluoromethylbenzene) tert-butoxycarbonylamine

N-(3-(4-methyl-1H-1-imidazolyl)-5-trifluoromethylbenzene) tert-butoxycarbonylamine

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 35℃; for 12h;86.5%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

methyl 4-methyl-3-(4-(pyridin-3-yl)thiazol-2-ylamino)benzoate
1186620-63-2

methyl 4-methyl-3-(4-(pyridin-3-yl)thiazol-2-ylamino)benzoate

N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-phenyl)-4-methyl-3-(4-pyridin-3-yl-thiazol-2-ylamino)-benzamide
1234798-38-9

N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-phenyl)-4-methyl-3-(4-pyridin-3-yl-thiazol-2-ylamino)-benzamide

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at -20 - 20℃;86%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

3-iodo-4-methylbenzoyl chloride
52107-98-9

3-iodo-4-methylbenzoyl chloride

3-iodo-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide
926922-18-1

3-iodo-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide

Conditions
ConditionsYield
Stage #1: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline; 3-iodo-4-methylbenzoyl chloride In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere;
Stage #2: With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran
85%
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 2h;4.60 g
With N-ethyl-N,N-diisopropylamine; dmap In tetrahydrofuran at 20℃; for 2h;
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

4-methyl-3-(4-pyrazine-2-yl-pyrimidine-2-yl-amino)-benzoic acid ethyl ester
926038-04-2

4-methyl-3-(4-pyrazine-2-yl-pyrimidine-2-yl-amino)-benzoic acid ethyl ester

Radotinib

Radotinib

Conditions
ConditionsYield
Stage #1: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline With potassium tert-butylate In tetrahydrofuran at -20℃; for 0.5h;
Stage #2: 4-methyl-3-(4-pyrazine-2-yl-pyrimidine-2-yl-amino)-benzoic acid ethyl ester In tetrahydrofuran at -20 - 20℃;
85%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

3-iodo-4-toluic acid
82998-57-0

3-iodo-4-toluic acid

3-iodo-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide
926922-18-1

3-iodo-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide

Conditions
ConditionsYield
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; thionyl chloride; water84.3%
Stage #1: 3-iodo-4-toluic acid With thionyl chloride for 6h;
Stage #2: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline With N-ethyl-N,N-diisopropylamine In chloroform at 60℃; for 5h;
57%
Stage #1: 3-iodo-4-toluic acid With thionyl chloride for 1h; Reflux;
Stage #2: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 2h;
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

3-((tert-butoxycarbonyl)amino)-4-methylbenzoic acid ethyl ester

3-((tert-butoxycarbonyl)amino)-4-methylbenzoic acid ethyl ester

N-(2-methyl-5-((3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamoyl)phenyl)carbamic acid tert-butyl ester

N-(2-methyl-5-((3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamoyl)phenyl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
With potassium tert-butylate In N,N-dimethyl-formamide at -10 - -5℃; Reagent/catalyst; Solvent; Temperature;84%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

4-methyl-3-(4-pyrazine-2-yl-pyrimidine-2-yl-amino)-benzoic acid methyl ester
1207665-71-1

4-methyl-3-(4-pyrazine-2-yl-pyrimidine-2-yl-amino)-benzoic acid methyl ester

Radotinib

Radotinib

Conditions
ConditionsYield
Stage #1: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline With potassium tert-butylate In tetrahydrofuran at -20℃; for 0.5h;
Stage #2: 4-methyl-3-(4-pyrazine-2-yl-pyrimidine-2-yl-amino)-benzoic acid methyl ester In tetrahydrofuran at -20 - 20℃; Product distribution / selectivity;
83%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

methyl 3-(4-oxopyrimidin-2-ylamino)-4-methylbenzoate
1451042-82-2

methyl 3-(4-oxopyrimidin-2-ylamino)-4-methylbenzoate

4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(6-oxo-1,6-dihydropyrimidin-2-ylamino)benzamide
1451042-83-3

4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(6-oxo-1,6-dihydropyrimidin-2-ylamino)benzamide

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at -5 - 20℃; for 16h; Inert atmosphere;83%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

4-methyl-3-(4-thiazole-2-yl-pyrimidine-2-yl-amino)benzoic acid ethyl ester
926038-03-1

4-methyl-3-(4-thiazole-2-yl-pyrimidine-2-yl-amino)benzoic acid ethyl ester

4-methyl-N-[3-(4-methylimidazole-1-yl)-5-trifluoromethyl-phenyl]-3-(4-thiazole-2-yl-pyrimidine-2-yl-amino)benzamide

4-methyl-N-[3-(4-methylimidazole-1-yl)-5-trifluoromethyl-phenyl]-3-(4-thiazole-2-yl-pyrimidine-2-yl-amino)benzamide

Conditions
ConditionsYield
Stage #1: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline With potassium tert-butylate In tetrahydrofuran at -20℃; for 0.5h;
Stage #2: 4-methyl-3-(4-thiazole-2-yl-pyrimidine-2-yl-amino)benzoic acid ethyl ester In tetrahydrofuran at -20 - 20℃;
81%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

methyl 4-formylbenzoate
1571-08-0

methyl 4-formylbenzoate

methyl 4-({[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]amino}methyl)benzoate

methyl 4-({[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]amino}methyl)benzoate

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In chloroform at 20℃;81%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

4-methyl-3-(4-thiazole-2-yl-pyrimidine-2-yl-amino)benzoic acid methyl ester
1207665-69-7

4-methyl-3-(4-thiazole-2-yl-pyrimidine-2-yl-amino)benzoic acid methyl ester

4-methyl-N-[3-(4-methylimidazole-1-yl)-5-trifluoromethyl-phenyl]-3-(4-thiazole-2-yl-pyrimidine-2-yl-amino)benzamide

4-methyl-N-[3-(4-methylimidazole-1-yl)-5-trifluoromethyl-phenyl]-3-(4-thiazole-2-yl-pyrimidine-2-yl-amino)benzamide

Conditions
ConditionsYield
Stage #1: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline With potassium tert-butylate In tetrahydrofuran at -20℃; for 0.5h;
Stage #2: 4-methyl-3-(4-thiazole-2-yl-pyrimidine-2-yl-amino)benzoic acid methyl ester In tetrahydrofuran at -20 - 20℃; Product distribution / selectivity;
80%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

3-(4-imidazole-1-yl-pyrimidine-2-yl amino)-4-methyl-benzoic acid methyl ester
1207665-73-3

3-(4-imidazole-1-yl-pyrimidine-2-yl amino)-4-methyl-benzoic acid methyl ester

3-(4-imidazole-1-yl-pyrimidine-2-yl-amino)-4-methyl-N-[3-(4-methyl-imidazole-1-yl)-5-trifluoromethyl-phenyl] benzamide

3-(4-imidazole-1-yl-pyrimidine-2-yl-amino)-4-methyl-N-[3-(4-methyl-imidazole-1-yl)-5-trifluoromethyl-phenyl] benzamide

Conditions
ConditionsYield
Stage #1: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline With sodium t-butanolate In tetrahydrofuran at -20℃; for 0.5h;
Stage #2: 3-(4-imidazole-1-yl-pyrimidine-2-yl amino)-4-methyl-benzoic acid methyl ester In tetrahydrofuran at -20 - 20℃; Product distribution / selectivity;
76%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

3-(4-imidazole-1-yl-pyrimidine-2-yl-amino)-4-methyl-benzoic acid ethyl ester
926038-10-0

3-(4-imidazole-1-yl-pyrimidine-2-yl-amino)-4-methyl-benzoic acid ethyl ester

3-(4-imidazole-1-yl-pyrimidine-2-yl-amino)-4-methyl-N-[3-(4-methyl-imidazole-1-yl)-5-trifluoromethyl-phenyl] benzamide

3-(4-imidazole-1-yl-pyrimidine-2-yl-amino)-4-methyl-N-[3-(4-methyl-imidazole-1-yl)-5-trifluoromethyl-phenyl] benzamide

Conditions
ConditionsYield
Stage #1: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline With potassium tert-butylate In tetrahydrofuran at -20℃; for 0.5h;
Stage #2: 3-(4-imidazole-1-yl-pyrimidine-2-yl-amino)-4-methyl-benzoic acid ethyl ester In tetrahydrofuran at -20 - 20℃;
73%

Downstream Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View