Cas no. 641571-10-0 Nilotinib Nilotinib Intermediates Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manufacturer. 2.Professional team.
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:641571-10-0
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inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:641571-10-0
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inquiryItems Standard Result Appearance Off-white to pale yellow powder Pale yellow powder Identification
Cas:641571-10-0
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Type:Manufacturers
inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
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inquiryUnique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Almost white powder Storage:cool dry place Package:10g/100g/1kg/foil bag Application:medicine raw material Transpo
Cas:641571-10-0
Min.Order:10 Gram
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:641571-10-0
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inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:641571-10-0
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:Nilotinib CAS:641571-10-0 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability P
Cas:641571-10-0
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inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:641571-10-0
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inquiry1. Introduction of Nilotinib Nilotinib is one kind of white to off white powder or off-white solid. The IUPAC Name of this chemical is 4-Methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamid
We are one of reliable manufacturer and supplier of chemicals in China , our own R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the
Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
Cas:641571-10-0
Min.Order:10 Gram
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Type:Other
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem (China) Co.,Ltd is Sp
Cas:641571-10-0
Min.Order:100 Gram
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Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:641571-10-0
Min.Order:10 Gram
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Type:Trading Company
inquiryNilotinib CAS:641571-10-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
Cas:641571-10-0
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
Cas:641571-10-0
Min.Order:10 Gram
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Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:641571-10-0
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:641571-10-0
Min.Order:10 Gram
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Type:Lab/Research institutions
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:641571-10-0
Min.Order:10 Kilogram
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Type:Trading Company
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:641571-10-0
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
carbon monoxide
nilotinib
Conditions | Yield |
---|---|
Stage #1: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline; carbon monoxide; 5-bromo-2-methylphenyl(4-(pyridin-3-yl)pyrimidin-2-yl)-carbamic acid tert-butyl ester With bis(benzonitrile)palladium(II) dichloride; triethylamine; 1,2-bis-(diphenylphosphino)ethane; phenol In N,N-dimethyl-formamide at 90 - 105℃; under 6000.6 Torr; for 48h; Molecular sieve; Inert atmosphere; Autoclave; Stage #2: With trifluoroacetic acid In ethanol Inert atmosphere; Stage #3: With potassium hydroxide In ethanol; water pH=6 - 9; Reagent/catalyst; Solvent; Pressure; Inert atmosphere; | 100% |
3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
nilotinib
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol for 40h; Reagent/catalyst; Reflux; | 95.2% |
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoic acid
nilotinib
Conditions | Yield |
---|---|
Stage #1: 4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid With thionyl chloride In 1-methyl-pyrrolidin-2-one at 60℃; for 1.25h; Stage #2: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline In 1-methyl-pyrrolidin-2-one at 90℃; for 3h; Product distribution / selectivity; | 94% |
Stage #1: 4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid With thionyl chloride In 1-methyl-pyrrolidin-2-one at 60℃; for 1.25h; Stage #2: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline In 1-methyl-pyrrolidin-2-one at 90℃; for 3h; Stage #3: With sodium hydroxide In 1-methyl-pyrrolidin-2-one; water at 80℃; pH=11 - 12; Product distribution / selectivity; | 94% |
Stage #1: 4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid With thionyl chloride In 1-methyl-pyrrolidin-2-one at 60℃; for 1.5h; Stage #2: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline In 1-methyl-pyrrolidin-2-one at 90℃; for 0.5h; | 90% |
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
nilotinib
Conditions | Yield |
---|---|
With trimethylaluminum In toluene for 5h; Concentration; Time; Reflux; | 91% |
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
methyl 4-methyl-3 -[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate
nilotinib
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran at 0 - 20℃; for 12h; Inert atmosphere; | 90% |
With sodium t-butanolate In tetrahydrofuran at 0 - 20℃; for 12h; Inert atmosphere; | 81% |
With potassium tert-butylate In tetrahydrofuran at -5 - 20℃; for 30h; Inert atmosphere; Large scale; | 68% |
nilotinib
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; water at 45 - 70℃; | 90% |
With sodium hydroxide In methanol; water at 45 - 70℃; | 90% |
3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
nilotinib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide / butan-1-ol / 12 h / Inert atmosphere; Reflux 2: C43H63ClNO2PPd; caesium carbonate / 1,4-dioxane / 1.5 h / 120 °C / Inert atmosphere 3: potassium tert-butylate / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1: sodium hydroxide / butan-1-ol / 12 h / Inert atmosphere; Reflux 2: C43H63ClNO2PPd; caesium carbonate / 1,4-dioxane / 1.5 h / 120 °C / Inert atmosphere 3: potassium tert-butylate / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere 4: 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; tris-(dibenzylideneacetone)dipalladium(0); potassium phosphate / 1,4-dioxane / 12 h / 120 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium hydroxide / butan-1-ol / 12 h / Inert atmosphere; Reflux 1.2: 0.33 h / 25 - 125 °C 1.3: 1 h / 25 - 35 °C 2.1: Carbonyldiimidazole; 1H-imidazole hydrochloride / 1-methyl-pyrrolidin-2-one / 2 h / 20 - 55 °C / Inert atmosphere 2.2: 24 h / 50 - 105 °C / Inert atmosphere View Scheme |
4-pyridin-3-ylpyrimidin-2-ylamine
nilotinib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: C43H63ClNO2PPd; caesium carbonate / 1,4-dioxane / 1.5 h / 120 °C / Inert atmosphere 2: potassium tert-butylate / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: C43H63ClNO2PPd; caesium carbonate / 1,4-dioxane / 1.5 h / 120 °C / Inert atmosphere 2: potassium tert-butylate / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere 3: 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; tris-(dibenzylideneacetone)dipalladium(0); potassium phosphate / 1,4-dioxane / 12 h / 120 °C / Inert atmosphere View Scheme |
[3-bromo-5-(trifluoromethyl)phenyl]amine
nilotinib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; tris-(dibenzylideneacetone)dipalladium(0); potassium phosphate / 1,4-dioxane; toluene / 12 h / 120 °C / Inert atmosphere 2: potassium tert-butylate / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: copper(l) iodide; 8-quinolinol; potassium carbonate / dimethyl sulfoxide / 18 h / 120 °C / Inert atmosphere; Sealed tube 2: sodium t-butanolate / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1.1: copper(l) iodide; 8-quinolinol; potassium carbonate / dimethyl sulfoxide / 18 h / 120 °C / Inert atmosphere; Sealed tube 2.1: thionyl chloride; N,N-dimethyl-formamide / 6 h / Reflux 2.2: 6 h / 0 - 20 °C View Scheme |
(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
nilotinib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide / butan-1-ol / 24 h / Reflux 2: 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; tert-butyl alcohol / 7 h / 100 °C View Scheme |
4-methyl-3-nitrobenzoic acid
nilotinib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: thionyl chloride / chloroform; N,N-dimethyl-formamide / 3 h / Reflux 2.1: chloroform; N,N-dimethyl-formamide / 5 h / 10 - 20 °C 3.1: tin(ll) chloride / methanol / 10 °C / Reflux 3.2: 2 h / 10 - 15 °C 4.1: hydrogenchloride / water; butan-1-ol / 20 h / 90 - 95 °C / pH 2-3 4.2: 2 h / 20 °C 5.1: butan-1-ol / 9 h / 110 - 115 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: thionyl chloride / chloroform; N,N-dimethyl-formamide / 3 h / Reflux 2.1: chloroform / 5 h / 10 - 20 °C 3.1: tin(ll) chloride / methanol / 3 h / 10 °C / Reflux 3.2: 20 °C 4.1: hydrogenchloride / water; butan-1-ol / 20 h / 90 - 95 °C / pH 2 - 3 5.1: butan-1-ol / 9 h / 110 - 115 °C View Scheme |
4-methyl-3-nitrobenzoyl chloride
nilotinib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: chloroform; N,N-dimethyl-formamide / 5 h / 10 - 20 °C 2.1: tin(ll) chloride / methanol / 10 °C / Reflux 2.2: 2 h / 10 - 15 °C 3.1: hydrogenchloride / water; butan-1-ol / 20 h / 90 - 95 °C / pH 2-3 3.2: 2 h / 20 °C 4.1: butan-1-ol / 9 h / 110 - 115 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: chloroform / 5 h / 10 - 20 °C 2.1: tin(ll) chloride / methanol / 3 h / 10 °C / Reflux 2.2: 20 °C 3.1: hydrogenchloride / water; butan-1-ol / 20 h / 90 - 95 °C / pH 2 - 3 4.1: butan-1-ol / 9 h / 110 - 115 °C View Scheme |
4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-nitrobenzamide hydrochloride
nilotinib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: tin(ll) chloride / methanol / 10 °C / Reflux 1.2: 2 h / 10 - 15 °C 2.1: hydrogenchloride / water; butan-1-ol / 20 h / 90 - 95 °C / pH 2-3 2.2: 2 h / 20 °C 3.1: butan-1-ol / 9 h / 110 - 115 °C View Scheme | |
Multi-step reaction with 3 steps 1: tin(ll) chloride / methanol / 10 °C / Reflux 2: hydrogenchloride / butan-1-ol; water / 20 h / 90 - 95 °C / pH 2 - 3 3: butan-1-ol / 9 h / 110 - 115 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: tin(ll) chloride / methanol / 3 h / 10 °C / Reflux 1.2: 20 °C 2.1: hydrogenchloride / water; butan-1-ol / 20 h / 90 - 95 °C / pH 2 - 3 3.1: butan-1-ol / 9 h / 110 - 115 °C View Scheme |
3-amino-p-toluic acid
nilotinib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: thionyl chloride; N,N-dimethyl-formamide / chloroform / 3 h / Reflux 2: chloroform / 10 - 20 °C 3: tin(ll) chloride / methanol / 10 °C / Reflux 4: hydrogenchloride / butan-1-ol; water / 20 h / 90 - 95 °C / pH 2 - 3 5: butan-1-ol / 9 h / 110 - 115 °C View Scheme |
nilotinib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: chloroform / 10 - 20 °C 2: tin(ll) chloride / methanol / 10 °C / Reflux 3: hydrogenchloride / butan-1-ol; water / 20 h / 90 - 95 °C / pH 2 - 3 4: butan-1-ol / 9 h / 110 - 115 °C View Scheme |
3-amino-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide
nilotinib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / butan-1-ol; water / 20 h / 90 - 95 °C / pH 2 - 3 2: butan-1-ol / 9 h / 110 - 115 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride / water; butan-1-ol / 20 h / 90 - 95 °C / pH 2 - 3 2: butan-1-ol / 9 h / 110 - 115 °C View Scheme |
methyl 3-(4-oxopyrimidin-2-ylamino)-4-methylbenzoate
nilotinib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium tert-butylate / tetrahydrofuran / 16 h / -5 - 20 °C / Inert atmosphere 2.1: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 3.5 h / 50 °C / Inert atmosphere 2.2: 0.5 h / 20 °C / Inert atmosphere 2.3: 22 h / Inert atmosphere; Reflux View Scheme |
3-amino-4-methyl benzoic acid methyl ester
nilotinib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogenchloride / water / 1.5 h / 130 - 160 °C / Inert atmosphere 2.1: potassium tert-butylate / tetrahydrofuran / 16 h / -5 - 20 °C / Inert atmosphere 3.1: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 3.5 h / 50 °C / Inert atmosphere 3.2: 0.5 h / 20 °C / Inert atmosphere 3.3: 22 h / Inert atmosphere; Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: hydrogenchloride / ethanol; water / 6 h / 25 - 85 °C / Inert atmosphere 1.2: 0.75 h / 0 - 5 °C 2.1: sodium hydroxide / butan-1-ol / 12 h / Inert atmosphere; Reflux 2.2: 0.33 h / 25 - 125 °C 2.3: 1 h / 25 - 35 °C 3.1: Carbonyldiimidazole; 1H-imidazole hydrochloride / 1-methyl-pyrrolidin-2-one / 2 h / 20 - 55 °C / Inert atmosphere 3.2: 24 h / 50 - 105 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1: butan-1-ol / 50 - 55 °C 2: potassium carbonate / N,N-dimethyl-formamide / -10 - 0 °C 3: hydrogenchloride / butan-1-ol; water / 90 - 100 °C 4: butan-1-ol; water / 90 - 100 °C 5: potassium carbonate / N,N-dimethyl-formamide / 100 - 110 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: triethylamine / methanol; dichloromethane / 24 h / 40 °C 2.1: dichloromethane / 12 h / 20 °C 3.1: sodium hydroxide / 36 h / 110 - 120 °C 4.1: lithium hydroxide; water / methanol; tetrahydrofuran / 12 h / 20 °C 5.1: thionyl chloride; N,N-dimethyl-formamide / 6 h / Reflux 5.2: 6 h / 0 - 20 °C View Scheme |
3-[(aminoiminomethyl)amino]-4-methylbenzoic acid methylester mononitrate
nilotinib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydroxide / butan-1-ol / 12 h / Inert atmosphere; Reflux 1.2: 0.33 h / 25 - 125 °C 1.3: 1 h / 25 - 35 °C 2.1: Carbonyldiimidazole; 1H-imidazole hydrochloride / 1-methyl-pyrrolidin-2-one / 2 h / 20 - 55 °C / Inert atmosphere 2.2: 24 h / 50 - 105 °C / Inert atmosphere View Scheme |
N-(2-methyl-5-nitrophenyl)guanidinium hydrochloride
3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
nilotinib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / propan-1-ol / 24 h / Reflux 2: thionyl chloride View Scheme |
nilotinib
Conditions | Yield |
---|---|
With sodium hydroxide In 1-methyl-pyrrolidin-2-one; water at 20 - 25℃; for 3h; |
Conditions | Yield |
---|---|
Stage #1: nilotinib; levulinic acid at 55 - 60℃; Stage #2: With hydrogenchloride In isopropyl alcohol at 55 - 60℃; for 1h; Temperature; | 99.5% |
nilotinib
Conditions | Yield |
---|---|
With hydrogenchloride In water; acetone at 20 - 25℃; for 5h; | 98% |
With methanol; acetyl chloride at 0 - 5℃; | 75% |
With methanol; acetyl chloride for 2h; | 75% |
Conditions | Yield |
---|---|
In ethyl acetate at 20 - 25℃; for 16h; | 97% |
nilotinib
Conditions | Yield |
---|---|
With hydrogenchloride In N,N-dimethyl acetamide; water at 24 - 30℃; for 1.5h; Product distribution / selectivity; | 96% |
With hydrogenchloride In ethanol; water at 20 - 70℃; for 18h; | 90% |
With hydrogenchloride In methanol; water at 55 - 60℃; for 0.1h; | 140 g |
nilotinib
(2E)-but-2-enedioic acid
Conditions | Yield |
---|---|
In ethanol; butan-1-ol at 90 - 95℃; Temperature; Solvent; | 93.6% |
Conditions | Yield |
---|---|
In ethyl acetate at 50℃; | 92% |
Conditions | Yield |
---|---|
With hydrogen bromide In methanol; water at 25 - 60℃; for 2h; | 88.81% |
Conditions | Yield |
---|---|
In acetone at 20 - 55℃; Temperature; Solvent; | 87% |
Conditions | Yield |
---|---|
In ethyl acetate Reflux; | 84% |
nilotinib
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol Product distribution / selectivity; Reflux; | 83% |
With hydrogenchloride In methanol; water for 0.5h; Product distribution / selectivity; | 72.6% |
With hydrogenchloride In ethanol; acetone at 24 - 30℃; for 5h; Product distribution / selectivity; | 58% |
Conditions | Yield |
---|---|
In methanol at 30 - 60℃; Temperature; | 83% |
nilotinib
lysophosphatidic acid
Conditions | Yield |
---|---|
In water; acetone at 20 - 25℃; for 45h; | 81% |
nilotinib
oxalic acid
Conditions | Yield |
---|---|
In 2-methoxy-ethanol at 55 - 100℃; for 0.5h; | 78.7% |
Conditions | Yield |
---|---|
In 2,2,2-trifluoroethanol at 45 - 50℃; for 3h; Product distribution / selectivity; | 74% |
nilotinib
toluene-4-sulfonic acid
4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide p-toluenesulfonate
Conditions | Yield |
---|---|
In ethyl acetate at 20 - 76℃; Product distribution / selectivity; | |
In ethyl acetate at 76℃; for 5h; Product distribution / selectivity; | |
In tetrahydrofuran at 50℃; Product distribution / selectivity; |
nilotinib
methanesulfonic acid
4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide methanesulfonate
Conditions | Yield |
---|---|
In ethyl acetate at 25 - 76℃; Product distribution / selectivity; | |
In ethyl acetate at 20 - 76℃; for 5h; Product distribution / selectivity; | |
In tetrahydrofuran at 50℃; Product distribution / selectivity; |
nilotinib
ethanesulfonic acid
4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide ethanesulfonate
Conditions | Yield |
---|---|
In acetone at 50℃; Product distribution / selectivity; | |
In tetrahydrofuran at 50℃; Product distribution / selectivity; | |
In acetone at 50℃; Product distribution / selectivity; |
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