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Yangzhou Qinyuan Pharmatech Co.,Ltd

Cas no. 641571-10-0 Nilotinib Nilotinib Intermediates Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manufacturer. 2.Professional team.

Nilotinib

Cas:641571-10-0

Min.Order:100 Gram

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Nilotinib Manufacturer/High quality/Best price/In stock

Cas:641571-10-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up by HPLC Nilotinib 641571-10-0

Cas:641571-10-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance Off-white to pale yellow powder Pale yellow powder Identification

High purity Nilotinib CAS:641571-10-0

Cas:641571-10-0

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Nilotinib 641571-10-0 API

Cas:641571-10-0

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Almost white powder Storage:cool dry place Package:10g/100g/1kg/foil bag Application:medicine raw material Transpo

Manufacturer high quality Nilotinib Cas 641571-10-0 with good price

Cas:641571-10-0

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Nilotinib 641571-10-0 GMP Manufacturer

Cas:641571-10-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Nilotinib

Cas:641571-10-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Nilotinib

Cas:641571-10-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Nilotinib CAS:641571-10-0 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability P

High purity Nilotinib CAS:641571-10-0

Cas:641571-10-0

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Nilotinib

Cas:641571-10-0

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Nilotinib

Cas:641571-10-0

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 641571-10-0 with best quality

Cas:641571-10-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

1. Introduction of Nilotinib Nilotinib is one kind of white to off white powder or off-white solid. The IUPAC Name of this chemical is 4-Methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamid

Nilotinib

Cas:641571-10-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Antimex Chemical Limied

We are one of reliable manufacturer and supplier of chemicals in China , our own R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the

Nilotinib

Cas:641571-10-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

API Imatinib Nilotinib Manufacturer 641571-10-0 For Cancer Treatment

Cas:641571-10-0

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem (China) Co.,Ltd is Sp

Top purity API Nilotinib,Treat for chronic myelogenous leukemia 641571-10-0

Cas:641571-10-0

Min.Order:100 Gram

FOB Price: $10.0

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Anticancer Apis Raw Material Nilotinib Powder / 99% Purity Raw Powder Nilotinib

Cas:641571-10-0

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Nilotinib CAS:641571-10-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Nilotinib CAS:641571-10-0

Cas:641571-10-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Nilotinib

Cas:641571-10-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

High Quality 99% Purity CAS 641571-10-0 Nilotinib

Cas:641571-10-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:641571-10-0

Cas:641571-10-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

nilotinib

Cas:641571-10-0

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

High Purity Nilotinib CAS 641571-10-0 with Fast Shipment

Cas:641571-10-0

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Nilotinib 641571-10-0

Cas:641571-10-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

first-class Nilotinib/Nilotinib global trader/641571-10-0 in stock

Cas:641571-10-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Nilotinib & its intermediates

Cas:641571-10-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

afine-Nilotinib

Cas:641571-10-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Nilotinib

Cas:641571-10-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

carbon monoxide
201230-82-2

carbon monoxide

5-bromo-2-methylphenyl(4-(pyridin-3-yl)pyrimidin-2-yl)-carbamic acid tert-butyl ester

5-bromo-2-methylphenyl(4-(pyridin-3-yl)pyrimidin-2-yl)-carbamic acid tert-butyl ester

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
Stage #1: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline; carbon monoxide; 5-bromo-2-methylphenyl(4-(pyridin-3-yl)pyrimidin-2-yl)-carbamic acid tert-butyl ester With bis(benzonitrile)palladium(II) dichloride; triethylamine; 1,2-bis-(diphenylphosphino)ethane; phenol In N,N-dimethyl-formamide at 90 - 105℃; under 6000.6 Torr; for 48h; Molecular sieve; Inert atmosphere; Autoclave;
Stage #2: With trifluoroacetic acid In ethanol Inert atmosphere;
Stage #3: With potassium hydroxide In ethanol; water pH=6 - 9; Reagent/catalyst; Solvent; Pressure; Inert atmosphere;
100%
4-methyl-N-[3-(4-methyl-1H-imidazolyl)-5-trifluoromethylphenyl]-3-guanidinobenzamide nitrate

4-methyl-N-[3-(4-methyl-1H-imidazolyl)-5-trifluoromethylphenyl]-3-guanidinobenzamide nitrate

3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
55314-16-4, 75415-01-9, 123367-26-0

3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
With sodium hydroxide In ethanol for 40h; Reagent/catalyst; Reflux;95.2%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoic acid
641569-94-0

4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoic acid

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
Stage #1: 4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid With thionyl chloride In 1-methyl-pyrrolidin-2-one at 60℃; for 1.25h;
Stage #2: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline In 1-methyl-pyrrolidin-2-one at 90℃; for 3h; Product distribution / selectivity;
94%
Stage #1: 4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid With thionyl chloride In 1-methyl-pyrrolidin-2-one at 60℃; for 1.25h;
Stage #2: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline In 1-methyl-pyrrolidin-2-one at 90℃; for 3h;
Stage #3: With sodium hydroxide In 1-methyl-pyrrolidin-2-one; water at 80℃; pH=11 - 12; Product distribution / selectivity;
94%
Stage #1: 4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid With thionyl chloride In 1-methyl-pyrrolidin-2-one at 60℃; for 1.5h;
Stage #2: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline In 1-methyl-pyrrolidin-2-one at 90℃; for 0.5h;
90%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester

4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
With trimethylaluminum In toluene for 5h; Concentration; Time; Reflux;91%
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

methyl 4-methyl-3 -[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate
917392-54-2

methyl 4-methyl-3 -[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 0 - 20℃; for 12h; Inert atmosphere;90%
With sodium t-butanolate In tetrahydrofuran at 0 - 20℃; for 12h; Inert atmosphere;81%
With potassium tert-butylate In tetrahydrofuran at -5 - 20℃; for 30h; Inert atmosphere; Large scale;68%
nilotinib trihydrochloride

nilotinib trihydrochloride

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
With sodium hydroxide In methanol; water at 45 - 70℃;90%
With sodium hydroxide In methanol; water at 45 - 70℃;90%
3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
55314-16-4, 75415-01-9, 123367-26-0

3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / butan-1-ol / 12 h / Inert atmosphere; Reflux
2: C43H63ClNO2PPd; caesium carbonate / 1,4-dioxane / 1.5 h / 120 °C / Inert atmosphere
3: potassium tert-butylate / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: sodium hydroxide / butan-1-ol / 12 h / Inert atmosphere; Reflux
2: C43H63ClNO2PPd; caesium carbonate / 1,4-dioxane / 1.5 h / 120 °C / Inert atmosphere
3: potassium tert-butylate / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere
4: 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; tris-(dibenzylideneacetone)dipalladium(0); potassium phosphate / 1,4-dioxane / 12 h / 120 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydroxide / butan-1-ol / 12 h / Inert atmosphere; Reflux
1.2: 0.33 h / 25 - 125 °C
1.3: 1 h / 25 - 35 °C
2.1: Carbonyldiimidazole; 1H-imidazole hydrochloride / 1-methyl-pyrrolidin-2-one / 2 h / 20 - 55 °C / Inert atmosphere
2.2: 24 h / 50 - 105 °C / Inert atmosphere
View Scheme
4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: C43H63ClNO2PPd; caesium carbonate / 1,4-dioxane / 1.5 h / 120 °C / Inert atmosphere
2: potassium tert-butylate / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: C43H63ClNO2PPd; caesium carbonate / 1,4-dioxane / 1.5 h / 120 °C / Inert atmosphere
2: potassium tert-butylate / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere
3: 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; tris-(dibenzylideneacetone)dipalladium(0); potassium phosphate / 1,4-dioxane / 12 h / 120 °C / Inert atmosphere
View Scheme
[3-bromo-5-(trifluoromethyl)phenyl]amine
54962-75-3

[3-bromo-5-(trifluoromethyl)phenyl]amine

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; tris-(dibenzylideneacetone)dipalladium(0); potassium phosphate / 1,4-dioxane; toluene / 12 h / 120 °C / Inert atmosphere
2: potassium tert-butylate / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: copper(l) iodide; 8-quinolinol; potassium carbonate / dimethyl sulfoxide / 18 h / 120 °C / Inert atmosphere; Sealed tube
2: sodium t-butanolate / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: copper(l) iodide; 8-quinolinol; potassium carbonate / dimethyl sulfoxide / 18 h / 120 °C / Inert atmosphere; Sealed tube
2.1: thionyl chloride; N,N-dimethyl-formamide / 6 h / Reflux
2.2: 6 h / 0 - 20 °C
View Scheme
(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
55314-16-4, 75415-01-9, 123367-26-0

(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / butan-1-ol / 24 h / Reflux
2: 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane; tert-butyl alcohol / 7 h / 100 °C
View Scheme
4-methyl-3-nitrobenzoic acid
96-98-0

4-methyl-3-nitrobenzoic acid

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: thionyl chloride / chloroform; N,N-dimethyl-formamide / 3 h / Reflux
2.1: chloroform; N,N-dimethyl-formamide / 5 h / 10 - 20 °C
3.1: tin(ll) chloride / methanol / 10 °C / Reflux
3.2: 2 h / 10 - 15 °C
4.1: hydrogenchloride / water; butan-1-ol / 20 h / 90 - 95 °C / pH 2-3
4.2: 2 h / 20 °C
5.1: butan-1-ol / 9 h / 110 - 115 °C
View Scheme
Multi-step reaction with 5 steps
1.1: thionyl chloride / chloroform; N,N-dimethyl-formamide / 3 h / Reflux
2.1: chloroform / 5 h / 10 - 20 °C
3.1: tin(ll) chloride / methanol / 3 h / 10 °C / Reflux
3.2: 20 °C
4.1: hydrogenchloride / water; butan-1-ol / 20 h / 90 - 95 °C / pH 2 - 3
5.1: butan-1-ol / 9 h / 110 - 115 °C
View Scheme
4-methyl-3-nitrobenzoyl chloride
10397-30-5

4-methyl-3-nitrobenzoyl chloride

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: chloroform; N,N-dimethyl-formamide / 5 h / 10 - 20 °C
2.1: tin(ll) chloride / methanol / 10 °C / Reflux
2.2: 2 h / 10 - 15 °C
3.1: hydrogenchloride / water; butan-1-ol / 20 h / 90 - 95 °C / pH 2-3
3.2: 2 h / 20 °C
4.1: butan-1-ol / 9 h / 110 - 115 °C
View Scheme
Multi-step reaction with 4 steps
1.1: chloroform / 5 h / 10 - 20 °C
2.1: tin(ll) chloride / methanol / 3 h / 10 °C / Reflux
2.2: 20 °C
3.1: hydrogenchloride / water; butan-1-ol / 20 h / 90 - 95 °C / pH 2 - 3
4.1: butan-1-ol / 9 h / 110 - 115 °C
View Scheme
4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-nitrobenzamide hydrochloride
1449570-25-5

4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-nitrobenzamide hydrochloride

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: tin(ll) chloride / methanol / 10 °C / Reflux
1.2: 2 h / 10 - 15 °C
2.1: hydrogenchloride / water; butan-1-ol / 20 h / 90 - 95 °C / pH 2-3
2.2: 2 h / 20 °C
3.1: butan-1-ol / 9 h / 110 - 115 °C
View Scheme
Multi-step reaction with 3 steps
1: tin(ll) chloride / methanol / 10 °C / Reflux
2: hydrogenchloride / butan-1-ol; water / 20 h / 90 - 95 °C / pH 2 - 3
3: butan-1-ol / 9 h / 110 - 115 °C
View Scheme
Multi-step reaction with 3 steps
1.1: tin(ll) chloride / methanol / 3 h / 10 °C / Reflux
1.2: 20 °C
2.1: hydrogenchloride / water; butan-1-ol / 20 h / 90 - 95 °C / pH 2 - 3
3.1: butan-1-ol / 9 h / 110 - 115 °C
View Scheme
3-amino-p-toluic acid
2458-12-0

3-amino-p-toluic acid

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: thionyl chloride; N,N-dimethyl-formamide / chloroform / 3 h / Reflux
2: chloroform / 10 - 20 °C
3: tin(ll) chloride / methanol / 10 °C / Reflux
4: hydrogenchloride / butan-1-ol; water / 20 h / 90 - 95 °C / pH 2 - 3
5: butan-1-ol / 9 h / 110 - 115 °C
View Scheme
3-amino-4-methylbenzoyl chloride

3-amino-4-methylbenzoyl chloride

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: chloroform / 10 - 20 °C
2: tin(ll) chloride / methanol / 10 °C / Reflux
3: hydrogenchloride / butan-1-ol; water / 20 h / 90 - 95 °C / pH 2 - 3
4: butan-1-ol / 9 h / 110 - 115 °C
View Scheme
3-amino-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide
915711-42-1

3-amino-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / butan-1-ol; water / 20 h / 90 - 95 °C / pH 2 - 3
2: butan-1-ol / 9 h / 110 - 115 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrogenchloride / water; butan-1-ol / 20 h / 90 - 95 °C / pH 2 - 3
2: butan-1-ol / 9 h / 110 - 115 °C
View Scheme
methyl 3-(4-oxopyrimidin-2-ylamino)-4-methylbenzoate
1451042-82-2

methyl 3-(4-oxopyrimidin-2-ylamino)-4-methylbenzoate

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / tetrahydrofuran / 16 h / -5 - 20 °C / Inert atmosphere
2.1: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 3.5 h / 50 °C / Inert atmosphere
2.2: 0.5 h / 20 °C / Inert atmosphere
2.3: 22 h / Inert atmosphere; Reflux
View Scheme
3-amino-4-methyl benzoic acid methyl ester
18595-18-1

3-amino-4-methyl benzoic acid methyl ester

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogenchloride / water / 1.5 h / 130 - 160 °C / Inert atmosphere
2.1: potassium tert-butylate / tetrahydrofuran / 16 h / -5 - 20 °C / Inert atmosphere
3.1: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 3.5 h / 50 °C / Inert atmosphere
3.2: 0.5 h / 20 °C / Inert atmosphere
3.3: 22 h / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: hydrogenchloride / ethanol; water / 6 h / 25 - 85 °C / Inert atmosphere
1.2: 0.75 h / 0 - 5 °C
2.1: sodium hydroxide / butan-1-ol / 12 h / Inert atmosphere; Reflux
2.2: 0.33 h / 25 - 125 °C
2.3: 1 h / 25 - 35 °C
3.1: Carbonyldiimidazole; 1H-imidazole hydrochloride / 1-methyl-pyrrolidin-2-one / 2 h / 20 - 55 °C / Inert atmosphere
3.2: 24 h / 50 - 105 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1: butan-1-ol / 50 - 55 °C
2: potassium carbonate / N,N-dimethyl-formamide / -10 - 0 °C
3: hydrogenchloride / butan-1-ol; water / 90 - 100 °C
4: butan-1-ol; water / 90 - 100 °C
5: potassium carbonate / N,N-dimethyl-formamide / 100 - 110 °C
View Scheme
Multi-step reaction with 5 steps
1.1: triethylamine / methanol; dichloromethane / 24 h / 40 °C
2.1: dichloromethane / 12 h / 20 °C
3.1: sodium hydroxide / 36 h / 110 - 120 °C
4.1: lithium hydroxide; water / methanol; tetrahydrofuran / 12 h / 20 °C
5.1: thionyl chloride; N,N-dimethyl-formamide / 6 h / Reflux
5.2: 6 h / 0 - 20 °C
View Scheme
3-[(aminoiminomethyl)amino]-4-methylbenzoic acid methylester mononitrate
1025716-99-7

3-[(aminoiminomethyl)amino]-4-methylbenzoic acid methylester mononitrate

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydroxide / butan-1-ol / 12 h / Inert atmosphere; Reflux
1.2: 0.33 h / 25 - 125 °C
1.3: 1 h / 25 - 35 °C
2.1: Carbonyldiimidazole; 1H-imidazole hydrochloride / 1-methyl-pyrrolidin-2-one / 2 h / 20 - 55 °C / Inert atmosphere
2.2: 24 h / 50 - 105 °C / Inert atmosphere
View Scheme
N-(2-methyl-5-nitrophenyl)guanidinium hydrochloride
1207534-99-3

N-(2-methyl-5-nitrophenyl)guanidinium hydrochloride

3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
55314-16-4, 75415-01-9, 123367-26-0

3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / propan-1-ol / 24 h / Reflux
2: thionyl chloride
View Scheme
Nilotinib hydrochloride

Nilotinib hydrochloride

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
With sodium hydroxide In 1-methyl-pyrrolidin-2-one; water at 20 - 25℃; for 3h;
nilotinib
641571-10-0

nilotinib

levulinic acid
123-76-2

levulinic acid

nilotinib hydrochloride di-levulinic acid co-crystal

nilotinib hydrochloride di-levulinic acid co-crystal

Conditions
ConditionsYield
Stage #1: nilotinib; levulinic acid at 55 - 60℃;
Stage #2: With hydrogenchloride In isopropyl alcohol at 55 - 60℃; for 1h; Temperature;
99.5%
nilotinib
641571-10-0

nilotinib

nilotinib trihydrochloride

nilotinib trihydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water; acetone at 20 - 25℃; for 5h;98%
With methanol; acetyl chloride at 0 - 5℃;75%
With methanol; acetyl chloride for 2h;75%
nilotinib
641571-10-0

nilotinib

glycolic Acid
79-14-1

glycolic Acid

nilotinib diglycolate

nilotinib diglycolate

Conditions
ConditionsYield
In ethyl acetate at 20 - 25℃; for 16h;97%
nilotinib
641571-10-0

nilotinib

4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide dihydrochloride

4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide dihydrochloride

Conditions
ConditionsYield
With hydrogenchloride In N,N-dimethyl acetamide; water at 24 - 30℃; for 1.5h; Product distribution / selectivity;96%
With hydrogenchloride In ethanol; water at 20 - 70℃; for 18h;90%
With hydrogenchloride In methanol; water at 55 - 60℃; for 0.1h;140 g
nilotinib
641571-10-0

nilotinib

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-benzamide fumarate

4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-benzamide fumarate

Conditions
ConditionsYield
In ethanol; butan-1-ol at 90 - 95℃; Temperature; Solvent;93.6%
nilotinib
641571-10-0

nilotinib

levulinic acid
123-76-2

levulinic acid

nilotinib dilevulinate

nilotinib dilevulinate

Conditions
ConditionsYield
In ethyl acetate at 50℃;92%
nilotinib
641571-10-0

nilotinib

sodium dodecyl-sulfate
151-21-3

sodium dodecyl-sulfate

nilotinib lauryl sulfate salt

nilotinib lauryl sulfate salt

Conditions
ConditionsYield
With hydrogen bromide In methanol; water at 25 - 60℃; for 2h;88.81%
nilotinib
641571-10-0

nilotinib

2,5-dihydroxybenzoic acid.
490-79-9

2,5-dihydroxybenzoic acid.

nilotinib gentisate

nilotinib gentisate

Conditions
ConditionsYield
In acetone at 20 - 55℃; Temperature; Solvent;87%
nilotinib
641571-10-0

nilotinib

benzoic acid
65-85-0

benzoic acid

nilotinib dibenzoate

nilotinib dibenzoate

Conditions
ConditionsYield
In ethyl acetate Reflux;84%
nilotinib
641571-10-0

nilotinib

Nilotinib hydrochloride

Nilotinib hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol Product distribution / selectivity; Reflux;83%
With hydrogenchloride In methanol; water for 0.5h; Product distribution / selectivity;72.6%
With hydrogenchloride In ethanol; acetone at 24 - 30℃; for 5h; Product distribution / selectivity;58%
nilotinib
641571-10-0

nilotinib

saccharin
81-07-2

saccharin

nilotinib saccharinate

nilotinib saccharinate

Conditions
ConditionsYield
In methanol at 30 - 60℃; Temperature;83%
nilotinib
641571-10-0

nilotinib

nilotinib glycerophosphate

nilotinib glycerophosphate

Conditions
ConditionsYield
In water; acetone at 20 - 25℃; for 45h;81%
nilotinib
641571-10-0

nilotinib

oxalic acid
144-62-7

oxalic acid

4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide mono-oxalate

4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide mono-oxalate

Conditions
ConditionsYield
In 2-methoxy-ethanol at 55 - 100℃; for 0.5h;78.7%
nilotinib
641571-10-0

nilotinib

maleic acid
110-16-7

maleic acid

nilotinib maleate
1353151-43-5

nilotinib maleate

Conditions
ConditionsYield
In 2,2,2-trifluoroethanol at 45 - 50℃; for 3h; Product distribution / selectivity;74%
nilotinib
641571-10-0

nilotinib

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide p-toluenesulfonate
923288-94-2

4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide p-toluenesulfonate

Conditions
ConditionsYield
In ethyl acetate at 20 - 76℃; Product distribution / selectivity;
In ethyl acetate at 76℃; for 5h; Product distribution / selectivity;
In tetrahydrofuran at 50℃; Product distribution / selectivity;
nilotinib
641571-10-0

nilotinib

methanesulfonic acid
75-75-2

methanesulfonic acid

4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide methanesulfonate
923288-92-0

4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide methanesulfonate

Conditions
ConditionsYield
In ethyl acetate at 25 - 76℃; Product distribution / selectivity;
In ethyl acetate at 20 - 76℃; for 5h; Product distribution / selectivity;
In tetrahydrofuran at 50℃; Product distribution / selectivity;
nilotinib
641571-10-0

nilotinib

ethanesulfonic acid
594-45-6

ethanesulfonic acid

4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide ethanesulfonate
923288-97-5

4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide ethanesulfonate

Conditions
ConditionsYield
In acetone at 50℃; Product distribution / selectivity;
In tetrahydrofuran at 50℃; Product distribution / selectivity;
In acetone at 50℃; Product distribution / selectivity;

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