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Shandong Xinhua Pharmaceutical Co.,Ltd

intermediate for pharmaceuticals and dyestuff Appearance:Yellow powder Storage:tightly from light Package:25kg/bag Application:intermediate for pigment Transportation:SEA Port:Qingdao

Edaravone

Cas:89-25-8

Min.Order:1000 Kilogram

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Edaravone

Cas:89-25-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 89-25-8 Edaravone

Cas:89-25-8

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

inquiry

Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carb

Edarvone CAS 89-25-8

Cas:89-25-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Cas 89-25-8 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:Store at RT

High quality 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Cas 89-25-8 with best price

Cas:89-25-8

Min.Order:1 Kilogram

FOB Price: $110.0 / 115.0

Type:Trading Company

inquiry

Hefei TNJ chemical industry co.,ltd

Quick Details CAS No.: 89-25-8 Other Names: 2,4-dihydro-5-methyl-2-phenyl-3h-pyrazol-3-one MF: C10H10N2O EINECS No.: 201-891-0 Place of Origin: Anhui, China (Mainland) Type: Agrochemical Intermediates, Pharmaceutical Interm

Edarvone/CAS 89-25-8

Cas:89-25-8

Min.Order:1 Metric Ton

FOB Price: $5000.0

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one

Cas:89-25-8

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

EAST CHEMSOURCES LIMITED

1-Phenyl-3-Methyl-5-Pyrazolone 【Product name】 1-Phenyl-3-Methyl-5-Pyrazolone 【Property】 light yellow crystal or powder 【Main application】 Mainly used in manufacturing pharmacy

1-Phenyl-3-Methyl-5-Pyrazolone

Cas:89-25-8

Min.Order:1 Kilogram

FOB Price: $2.0 / 3.0

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Edaravone

Cas:89-25-8

Min.Order:1

Negotiable

Type:Other

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Edaravone manufacturer with low price

Cas:89-25-8

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 3-Methyl-1-phenyl-2-pyrazolin-5-one 89-25-8 ISO Producer

Cas:89-25-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Edaravone

Cas:89-25-8

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:3-Methyl-1-phenyl-2-pyrazolin-5-one CAS NO:89-25-8 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security wit

High purity Edaravone CAS 89-25-8 supplied by manufacturer CAS NO.89-25-8

Cas:89-25-8

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one

Cas:89-25-8

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Basic information Product Name: 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Synonyms: TIMTEC-BB SBB003801;PMP;MONOPYRAZOLONE;MCI-186;EDARAVONE;C

89-25-8

Cas:89-25-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product name Edaravone CAS 89-25-8 Assay 99% Appearance Light yellow powder

Edaravone

Cas:89-25-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Edaravone Powder CAS No. 89-25-8

Cas:89-25-8

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Standard CAS 89-25-8 with best quality

Cas:89-25-8

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Items Result Appearance White Content 99.0%min Moisture <0.04% Brand

1-Phenyl-3-Methyl-5-Pyrazole CAS:89-25-8

Cas:89-25-8

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

3-Methyl-1-phenyl-2-pyrazolin-5-one 89-25-8

Cas:89-25-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Shanghai Minstar Chemical Co., Ltd

Product Name: 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one CAS: 89-25-8 MF: C10H10N2O MW: 174.2 EINECS: 201-891-0 Mol File: 89-25-8.mol 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Structure 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one

Cas:89-25-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

108-45-2 cas m-Phenylenediamine / MPD 1,3-Phenylenediamine: Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once

m-Phenylenediamine / MPD 1,3-Phenylenediamine

Cas:89-25-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

3-Methyl-1-phenyl-2-pyrazoline-5-one 89-25-8 with best price

Cas:89-25-8

Min.Order:1 Kilogram

FOB Price: $80.0 / 100.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High quality edaravone CAS 89-25-8 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and expo

High quality edaravone CAS 89-25-8

Cas:89-25-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3-Methyl-1-phenyl-2-pyrazolin-5-one

Cas:89-25-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

High quality 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one CAS NO.89-25-8

Cas:89-25-8

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:89-25-8

Cas:89-25-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

edaravone cas:89-25-8

Cas:89-25-8

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

inquiry

Lonwin Chemical Group Limited

1 2 3 4 5 Share on facebookShare on twitterShare on emailShare on printMore Sharing Services Edaravone CAS: 89-25-8 Specification Items Standard Result Assay (Ursolic acid) 9

Factory supply Edaravone

Cas:89-25-8

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Synthetic route

ethyl acetoacetate
141-97-9

ethyl acetoacetate

phenylhydrazine
100-63-0

phenylhydrazine

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
In acetic acid Heating;100%
for 0.166667h; Irradiation;100%
at 0 - 90℃; for 1.5h;100%
acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

phenylhydrazine
100-63-0

phenylhydrazine

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
With acetic acid for 3h; Reflux;98%
With cellulose sulfuric acid In water at 20℃; for 0.133333h; Knorr Pyrazole Synthesis; Green chemistry; regioselective reaction;92%
With Fe3O4(at)SiO2-bonded N-propyl-diethylenetetrasulfamic acid In water at 20℃; for 0.416667h; Catalytic behavior; Green chemistry;82%
4-methyleneoxetan-2-one
674-82-8

4-methyleneoxetan-2-one

phenylhydrazine
100-63-0

phenylhydrazine

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
Stage #1: 4-methyleneoxetan-2-one With ammonium hydroxide at 10℃; for 0.5h;
Stage #2: phenylhydrazine at 60℃; for 2h;
Stage #3: With hydrogenchloride In water for 1h; pH=5;
93%
5-methyl-2-phenylpyrazolidin-3-one
13292-56-3

5-methyl-2-phenylpyrazolidin-3-one

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
With sodium anthraquinone-2-sulfonate; palladium diacetate; potassium carbonate In chlorobenzene at 110℃; for 6h; Reagent/catalyst;92%
N-acetoacetylphenylhydroxyloamine
27991-08-8

N-acetoacetylphenylhydroxyloamine

A

N-Phenylhydroxylamine
100-65-2

N-Phenylhydroxylamine

B

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
With phenylhydrazine In chloroform for 3h; Ambient temperature;A 90%
B 81%
phenylhydrazine hydrochloride
59-88-1

phenylhydrazine hydrochloride

ethyl acetoacetate
141-97-9

ethyl acetoacetate

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
In ethanol at 75℃; for 7h;85%
In ethanol at 50 - 70℃; for 5h; Reflux;85%
With ammonia at 95℃; for 6h; pH=6;85%
phenylhydrazine hydrochloride
59-88-1

phenylhydrazine hydrochloride

ethyl acetoacetate
141-97-9

ethyl acetoacetate

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

A

edaravone
89-25-8

edaravone

B

4,4-methine-bis-(3-methyl-1-phenyl-2-pyrazolin-5-one)
61466-03-3, 4174-09-8

4,4-methine-bis-(3-methyl-1-phenyl-2-pyrazolin-5-one)

Conditions
ConditionsYield
With p-toluenesulfonic acid monohydrate at 110℃; for 1h; Kinetics; Reagent/catalyst; Temperature;A 78%
B 12%
With pyridine hydrochloride at 140℃; for 24h; Kinetics; Reagent/catalyst;A 39%
B 47%
5-isopropoxy-3-methyl-1-phenyl-1H-pyrazole

5-isopropoxy-3-methyl-1-phenyl-1H-pyrazole

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
With hydrogen bromide; acetic acid at 140℃; for 2h; Inert atmosphere;76%
carbon monoxide
201230-82-2

carbon monoxide

chloroacetone
78-95-5

chloroacetone

phenylhydrazine
100-63-0

phenylhydrazine

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
With palladium diacetate; triethylamine; triphenylphosphine In tetrahydrofuran at 110℃; under 20521.4 Torr; for 10h; Temperature; Reagent/catalyst; Solvent; Time; Autoclave; regioselective reaction;72%
ethyl acetoacetate
141-97-9

ethyl acetoacetate

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
With phenylhydrazine In ethanol67%
With phenylhydrazine In 1,4-dioxane; water11.17 g (64%)
tert-butyl acetoacetate
1694-31-1

tert-butyl acetoacetate

phenylhydrazine
100-63-0

phenylhydrazine

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
In ethanol at 50 - 80℃; for 7h; Temperature; Darkness;60.98%
3-Methyl-1-phenyl-2-pyrazoline-4,5-dione
881-05-0

3-Methyl-1-phenyl-2-pyrazoline-4,5-dione

N,N-dimethyl-aniline
121-69-7

N,N-dimethyl-aniline

malononitrile
109-77-3

malononitrile

A

bis-p-(N,N-dimethylaminophenyl)malonitrile
27781-29-9

bis-p-(N,N-dimethylaminophenyl)malonitrile

B

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
In ethanol for 2h; Heating;A 60%
B n/a
5-(fluoro-dimethylsilanyl)-3-methyl-1-phenyl-1H-pyrazole
387353-94-8

5-(fluoro-dimethylsilanyl)-3-methyl-1-phenyl-1H-pyrazole

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
With potassium fluoride; 3-chloro-benzenecarboperoxoic acid In N,N-dimethyl-formamide at -100℃;58%
3-Methyl-1-phenyl-2-pyrazoline-4,5-dione
881-05-0

3-Methyl-1-phenyl-2-pyrazoline-4,5-dione

N,N-diethylaniline
91-66-7

N,N-diethylaniline

malononitrile
109-77-3

malononitrile

A

bis-p-(N,N-diethylaminophenyl)malonitrile
27781-21-1

bis-p-(N,N-diethylaminophenyl)malonitrile

B

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
In ethanol for 2h; Heating;A 55%
B 42%
(4E)-4-benzylidene-5-methyl-2-phenyl-3,4-dihydropyrazol-3(3H)-one
130691-00-8

(4E)-4-benzylidene-5-methyl-2-phenyl-3,4-dihydropyrazol-3(3H)-one

2-amino-benzenethiol
137-07-5

2-amino-benzenethiol

A

2-Phenylbenzothiazole
883-93-2

2-Phenylbenzothiazole

B

edaravone
89-25-8

edaravone

C

4-phenyl-3-methyl-1-phenylpyrazolo[3,4-b][1,5]benzothiazepine

4-phenyl-3-methyl-1-phenylpyrazolo[3,4-b][1,5]benzothiazepine

Conditions
ConditionsYield
With acetic acid In ethanol for 3h; Heating;A 25%
B n/a
C 55%
formaldehyd
50-00-0

formaldehyd

1-Methoxymethyl-5-methyl-2-phenyl-1,2-dihydro-pyrazol-3-one
98395-57-4

1-Methoxymethyl-5-methyl-2-phenyl-1,2-dihydro-pyrazol-3-one

A

C21H20N4O2
98395-58-5

C21H20N4O2

B

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
With hydrogenchloride In methanol for 0.166667h; Heating;A 53%
B 46%
1-Methoxymethyl-5-methyl-2-phenyl-1,2-dihydro-pyrazol-3-one
98395-57-4

1-Methoxymethyl-5-methyl-2-phenyl-1,2-dihydro-pyrazol-3-one

A

C21H20N4O2
98395-58-5

C21H20N4O2

B

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
With hydrogenchloride In methanol for 0.166667h; Heating;A 53%
B 46%
3-phenylaminobut-2-enoic acid ethyl ester
6287-35-0, 17469-23-7, 66558-23-4

3-phenylaminobut-2-enoic acid ethyl ester

phenylhydrazine hydrochloride
59-88-1

phenylhydrazine hydrochloride

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
With potassium acetate In ethanol at 25℃; for 1h;50%
(E)-4-(4-chlorobenzylidene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
897030-44-3

(E)-4-(4-chlorobenzylidene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one

2-amino-benzenethiol
137-07-5

2-amino-benzenethiol

A

2-(4-chlorophenyl)benzothiazole
6265-91-4

2-(4-chlorophenyl)benzothiazole

B

edaravone
89-25-8

edaravone

C

4-(4-chlorophenyl)-3-methyl-1-phenylpyrazolo[3,4-b][1,5]benzothiazepine

4-(4-chlorophenyl)-3-methyl-1-phenylpyrazolo[3,4-b][1,5]benzothiazepine

Conditions
ConditionsYield
With acetic acid In ethanol for 3h; Heating;A 20%
B n/a
C 50%
polymer, product of polymerization of 4-vinylbenzyl-polytetrahydrofuran with styrene and 1,4-bis(4-vinylphenoxy)butane, with polytetrahydrofuran chain terminated with 2-phenylhydrazonopropylcarbonyloxy group

polymer, product of polymerization of 4-vinylbenzyl-polytetrahydrofuran with styrene and 1,4-bis(4-vinylphenoxy)butane, with polytetrahydrofuran chain terminated with 2-phenylhydrazonopropylcarbonyloxy group

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
With trifluoroacetic acid In acetonitrile at 20℃; for 0.5h;48%
polymer, product derived from polytetrahydrofuran-grafted 5-hydroxypentyl-JandaJel (polytetrahydrofuran wt percent 33.4) with substituted polytetrahydrofuran chain end-OH group on 2-phenylhydrazonopropylcarbonyloxy group

polymer, product derived from polytetrahydrofuran-grafted 5-hydroxypentyl-JandaJel (polytetrahydrofuran wt percent 33.4) with substituted polytetrahydrofuran chain end-OH group on 2-phenylhydrazonopropylcarbonyloxy group

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
With trifluoroacetic acid In acetonitrile at 20℃; for 0.5h;47%
cyclohexanone
108-94-1

cyclohexanone

(Z)-3-(5-Chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-cyano-acrylic acid ethyl ester

(Z)-3-(5-Chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-cyano-acrylic acid ethyl ester

A

edaravone
89-25-8

edaravone

B

2-Oxo-5,6,7,8-tetrahydro-2H-chromene-3-carbonitrile

2-Oxo-5,6,7,8-tetrahydro-2H-chromene-3-carbonitrile

Conditions
ConditionsYield
With piperidine In ethanol for 8h; Heating;A n/a
B 45%
(Z)-3-(5-Chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-cyano-acrylic acid ethyl ester

(Z)-3-(5-Chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-cyano-acrylic acid ethyl ester

A

edaravone
89-25-8

edaravone

B

2-Oxo-5,6,7,8-tetrahydro-2H-chromene-3-carbonitrile

2-Oxo-5,6,7,8-tetrahydro-2H-chromene-3-carbonitrile

Conditions
ConditionsYield
With piperidine; cyclohexanone In ethanol for 8h; Heating;A n/a
B 45%
E-1-phenyl-3-methyl-4-<(4-nitrophenyl)methylene>-5-pyrazolone
132603-48-6

E-1-phenyl-3-methyl-4-<(4-nitrophenyl)methylene>-5-pyrazolone

2-amino-benzenethiol
137-07-5

2-amino-benzenethiol

A

2-(4-nitrophenyl)benzothiazole
22868-34-4

2-(4-nitrophenyl)benzothiazole

B

edaravone
89-25-8

edaravone

C

4-(4-nitrophenyl)-3-methyl-1-phenylpyrazolo[3,4-b][1,5]benzothiazepine

4-(4-nitrophenyl)-3-methyl-1-phenylpyrazolo[3,4-b][1,5]benzothiazepine

Conditions
ConditionsYield
With acetic acid In ethanol for 3h; Heating;A 15%
B n/a
C 45%
polymer, product derived from polytetrahydrofuran-grafted 5-hydroxypentyl-JandaJel (polytetrahydrofuran wt percent 49.9) with substituted polytetrahydrofuran chain end-OH group on 2-phenylhydrazonopropylcarbonyloxy group

polymer, product derived from polytetrahydrofuran-grafted 5-hydroxypentyl-JandaJel (polytetrahydrofuran wt percent 49.9) with substituted polytetrahydrofuran chain end-OH group on 2-phenylhydrazonopropylcarbonyloxy group

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
With trifluoroacetic acid In acetonitrile at 20℃; for 0.5h;42%
phenylhydrazine hydrochloride
59-88-1

phenylhydrazine hydrochloride

ethyl 3-aminobut-2-enoate
626-34-6

ethyl 3-aminobut-2-enoate

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
With potassium acetate In ethanol at 25℃; for 0.75h;40%
phenylhydrazine
100-63-0

phenylhydrazine

resin-OCOCH2COMe

resin-OCOCH2COMe

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
In dichloromethane at 20℃; for 22h;40%
(Z)-3-pyrrolidin-1-yl-but-2-enoic acid ethyl ester
70526-06-6

(Z)-3-pyrrolidin-1-yl-but-2-enoic acid ethyl ester

phenylhydrazine hydrochloride
59-88-1

phenylhydrazine hydrochloride

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
With potassium acetate In ethanol at 25℃; for 1.41667h;21%
4-isopropylidene-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one
22123-17-7

4-isopropylidene-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one

edaravone
89-25-8

edaravone

Conditions
ConditionsYield
With piperidine In benzene for 48h; Product distribution; Ambient temperature;8%
C22H18NO(1+)*I3(1-)
121572-86-9

C22H18NO(1+)*I3(1-)

edaravone
89-25-8

edaravone

6,8-Dimethyl-7-[3-methyl-5-oxo-1-phenyl-1,5-dihydro-pyrazol-(4Z)-ylidene]-2,3-diphenyl-7H-indolizin-1-one
121030-55-5

6,8-Dimethyl-7-[3-methyl-5-oxo-1-phenyl-1,5-dihydro-pyrazol-(4Z)-ylidene]-2,3-diphenyl-7H-indolizin-1-one

Conditions
ConditionsYield
With pyridine for 1h; Ambient temperature;100%
2-(4,6-dimethyl-3-cyano-2-pyridinylthio)benzenediazonium nitrate

2-(4,6-dimethyl-3-cyano-2-pyridinylthio)benzenediazonium nitrate

edaravone
89-25-8

edaravone

4-[(4',6'-dimethyl-3'-cyano-2'-pyridinylthio)-2-phenylhydrazono]-5-methyl-2-phenyl-2,4-dihydropyrazole-3-one

4-[(4',6'-dimethyl-3'-cyano-2'-pyridinylthio)-2-phenylhydrazono]-5-methyl-2-phenyl-2,4-dihydropyrazole-3-one

Conditions
ConditionsYield
Stage #1: 2-(4,6-dimethyl-3-cyano-2-pyridinylthio)benzenediazonium nitrate; 3-methyl-1-phenylpyrazolin-5-(4H)-one for 0.0833333h; grinding;
Stage #2: With trimethylamine at 20℃; under 375.038 Torr; for 12h; Further stages.;
100%
α-bromoacetophenone
70-11-1

α-bromoacetophenone

edaravone
89-25-8

edaravone

(5-methyl-2-phenyl-2H-pyrazol-3-yl) (2-oxo-2-phenylethyl) ether

(5-methyl-2-phenyl-2H-pyrazol-3-yl) (2-oxo-2-phenylethyl) ether

Conditions
ConditionsYield
Stage #1: α-bromoacetophenone; 3-methyl-1-phenylpyrazolin-5-(4H)-one at 20℃; for 1h; ball-milling;
Stage #2: With sodium carbonate Further stages.;
100%
edaravone
89-25-8

edaravone

3-methyl-1-phenyl-1H-pyrazole-5(4H)-thione
22717-42-6

3-methyl-1-phenyl-1H-pyrazole-5(4H)-thione

Conditions
ConditionsYield
With Lawessons reagent In toluene Reflux;100%
With Lawessons reagent In toluene for 2h; Reflux;97%
With Lawessons reagent for 0.0833333h; Irradiation; microwave;70%
With Lawessons reagent In toluene at 110℃; for 2h; Inert atmosphere;
edaravone
89-25-8

edaravone

4-methoxycarbonyl aniline
619-45-4

4-methoxycarbonyl aniline

C18H16N4O3

C18H16N4O3

Conditions
ConditionsYield
Stage #1: 4-methoxycarbonyl aniline With hydrogenchloride; sodium nitrite In water at 0 - 40℃; for 1h;
Stage #2: 3-methyl-1-phenylpyrazolin-5-(4H)-one With sodium hydroxide In water at 2 - 5℃; for 1h;
99.6%
benzoyl chloride
98-88-4

benzoyl chloride

edaravone
89-25-8

edaravone

(3-methyl-1-phenyl-1H-pyrazol-5-yl) benzoate
56159-67-2

(3-methyl-1-phenyl-1H-pyrazol-5-yl) benzoate

Conditions
ConditionsYield
Stage #1: edaravone With potassium hydroxide In water; acetonitrile for 0.5h;
Stage #2: benzoyl chloride In dichloromethane; water; acetonitrile for 0.0833333h;
99%
With triethylamine In chloroform for 1h; Heating;90%
for 0.133333h; microwave irradiation;87%
acetic anhydride
108-24-7

acetic anhydride

edaravone
89-25-8

edaravone

(3-methyl-1-phenyl-1H-pyrazol-5-yl) acetate
138853-66-4

(3-methyl-1-phenyl-1H-pyrazol-5-yl) acetate

Conditions
ConditionsYield
With triethylamine In chloroform for 1h; Heating;99%
at 20℃; for 12h;65%
With 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one at 70 - 80℃;
4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

edaravone
89-25-8

edaravone

malononitrile
109-77-3

malononitrile

6-amino-4-(4-chlorophenyl)-5-cyano-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole
76973-35-8

6-amino-4-(4-chlorophenyl)-5-cyano-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride In water at 90℃; for 6h;99%
With imidazole spacer and sulfonic acid tagged silica coated magnetite nanoparticle In neat (no solvent) at 20℃; for 0.333333h; Catalytic behavior; Reagent/catalyst; Temperature;98%
With Fe3O4 (at) tris(hydroxymethyl)aminomethane-SO3H nanoparticles In ethanol; water at 100℃; for 0.0833333h;98%
benzaldehyde
100-52-7

benzaldehyde

edaravone
89-25-8

edaravone

malononitrile
109-77-3

malononitrile

6-amino-1,4-dihydro-3-methyl-1,4-diphenylpyrano[2,3-c]pyrazole-5-carbonitrile
53316-57-7

6-amino-1,4-dihydro-3-methyl-1,4-diphenylpyrano[2,3-c]pyrazole-5-carbonitrile

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride In water at 90℃; for 6h;99%
With rac-Pro-OH at 25℃; for 0.0833333h;99%
With trichloroacetic acid at 100℃; for 0.05h; neat (no solvent);98%
benzaldehyde
100-52-7

benzaldehyde

edaravone
89-25-8

edaravone

4,4'-(phenylmethylene)bis(3-methyl-1-phenyl-pyrazol-5-ol)
57303-46-5

4,4'-(phenylmethylene)bis(3-methyl-1-phenyl-pyrazol-5-ol)

Conditions
ConditionsYield
With MCM-41 nanoparticles-supported guanine bonded with zirconium(IV) In ethanol at 80℃; for 0.333333h; Green chemistry; chemoselective reaction;99%
With Mn/lysine(at)CoFe2O4 nanocomposite at 80℃; for 1h;99%
With 3-aminopropylated silica gel In acetonitrile at 20℃; for 0.166667h; tandem Knoevenagel-Michael reaction;98%
4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

edaravone
89-25-8

edaravone

malononitrile
109-77-3

malononitrile

6-amino-4-(4-methoxyphenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
53316-60-2

6-amino-4-(4-methoxyphenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

Conditions
ConditionsYield
With rac-Pro-OH at 25℃; for 0.166667h;99%
With sodium fluoride In methanol; water at 25℃; for 0.1h; Sonication;98%
With N-benzyl-N,N,N-triethylammonium chloride In water at 90℃; for 6h;96%
1-(3-methyl-2-butenyl)-pyrrol-2-carbaldehyde
110719-45-4

1-(3-methyl-2-butenyl)-pyrrol-2-carbaldehyde

edaravone
89-25-8

edaravone

2,4-dihydro-5-methyl-4-<1'-(3-methyl-2-butenyl)pyrrol-2-yl>methylene-2-phenyl-3H-pyrazol-3-one
110719-46-5

2,4-dihydro-5-methyl-4-<1'-(3-methyl-2-butenyl)pyrrol-2-yl>methylene-2-phenyl-3H-pyrazol-3-one

Conditions
ConditionsYield
With ethylenediamine diacetic acid In acetonitrile99%
4-nitrobenzenediazonium chloride
100-05-0

4-nitrobenzenediazonium chloride

edaravone
89-25-8

edaravone

5-methyl-4-(2-(4-nitrophenyl)hydrazono)-2-phenyl-2,4-dihydro-3H-pyrazol-3one

5-methyl-4-(2-(4-nitrophenyl)hydrazono)-2-phenyl-2,4-dihydro-3H-pyrazol-3one

Conditions
ConditionsYield
With trimethylamine at 20℃; under 375.038 Torr; for 12h;99%
4-methoxy-benzenediazonium; nitrate

4-methoxy-benzenediazonium; nitrate

edaravone
89-25-8

edaravone

4-(4-methoxyphenylhydrazono)-3-methyl-1-phenyl-4,5-dihydropyrazole-5-one

4-(4-methoxyphenylhydrazono)-3-methyl-1-phenyl-4,5-dihydropyrazole-5-one

Conditions
ConditionsYield
With trimethylamine at 20℃; under 375.038 Torr; for 12h;99%
4-methyl-benzoyl chloride
874-60-2

4-methyl-benzoyl chloride

edaravone
89-25-8

edaravone

3-methyl-1-phenyl-1H-pyrazol-5-yl 4-methylbenzoate

3-methyl-1-phenyl-1H-pyrazol-5-yl 4-methylbenzoate

Conditions
ConditionsYield
Stage #1: edaravone With potassium hydroxide In water; acetonitrile for 0.5h;
Stage #2: 4-methyl-benzoyl chloride In dichloromethane; water; acetonitrile for 0.0833333h;
99%
for 0.133333h; microwave irradiation;37%
4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

edaravone
89-25-8

edaravone

(3-methyl-1-phenyl-1H-pyrazol-5-yl) 4-chlorobenzoate

(3-methyl-1-phenyl-1H-pyrazol-5-yl) 4-chlorobenzoate

Conditions
ConditionsYield
With triethylamine In chloroform for 1h; Heating;99%
for 0.133333h; microwave irradiation;81%
With 1,1-dichloroethane; triethylamine at 50 - 60℃;
4-methyl-benzaldehyde
104-87-0

4-methyl-benzaldehyde

edaravone
89-25-8

edaravone

malononitrile
109-77-3

malononitrile

3-methyl-6-amino-5-cyano-4-(4-methylphenyl)-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole
53316-59-9

3-methyl-6-amino-5-cyano-4-(4-methylphenyl)-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride In water at 90℃; for 6h;99%
With imidazole spacer and sulfonic acid tagged silica coated magnetite nanoparticle In neat (no solvent) at 20℃; for 0.75h;94%
With [amberlite IRA900OH]-supported L-prolinate In ethanol for 0.3h; Catalytic behavior; Reflux;94%
2,4-dichlorobenzaldeyhde
874-42-0

2,4-dichlorobenzaldeyhde

edaravone
89-25-8

edaravone

malononitrile
109-77-3

malononitrile

6-amino-4-(2, 4-dichlorophenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2, 3-c]pyrazole-5-carbonitrile

6-amino-4-(2, 4-dichlorophenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2, 3-c]pyrazole-5-carbonitrile

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride In water at 90℃; for 6h;99%
With imidazole spacer and sulfonic acid tagged silica coated magnetite nanoparticle In neat (no solvent) at 20℃; for 0.25h;97%
With triethylammonium acetate at 20℃; for 0.5h;96%
pyridoxal hydrochloride
65-22-5

pyridoxal hydrochloride

edaravone
89-25-8

edaravone

1-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-methyl-1,3-dihydro-furo[3,4-c]pyridin-7-ol
854010-13-2

1-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-methyl-1,3-dihydro-furo[3,4-c]pyridin-7-ol

Conditions
ConditionsYield
With sodium carbonate In water at 10 - 20℃; pH=2.04; Reagent/catalyst; pH-value;99%
With sodium hydroxide In water at 20℃; for 0.5h;6.8%
With sodium hydroxide In water at 20 - 30℃; for 2h; pH=6.3 - 12.1; Time;
4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

edaravone
89-25-8

edaravone

4,4′-[(4-flurophenyl)methylene]-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)

4,4′-[(4-flurophenyl)methylene]-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)

Conditions
ConditionsYield
In ethanol at 78℃; for 0.0833333h; Green chemistry;99%
With 2-carbamoylhydrazine-1-sulfonic acid In neat (no solvent) at 60℃; for 0.416667h; Reagent/catalyst; Green chemistry;97%
With phosphomolybdic acid In ethanol at 20℃; for 4h;94%
N,N-phenylbistrifluoromethane-sulfonimide
37595-74-7

N,N-phenylbistrifluoromethane-sulfonimide

edaravone
89-25-8

edaravone

trifluoromethanesulfonic acid 5-methyl-2-phenyl-2H-pyrazol-3-yl ester
276249-49-1

trifluoromethanesulfonic acid 5-methyl-2-phenyl-2H-pyrazol-3-yl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 35℃; for 3h;99%
(2-nitroethenyl)benzene
102-96-5

(2-nitroethenyl)benzene

edaravone
89-25-8

edaravone

(R)-5-methyl-4-(2-nitro-1-phenylethyl)-2-phenyl-2H-pyrazol-3-ol
1440200-00-9

(R)-5-methyl-4-(2-nitro-1-phenylethyl)-2-phenyl-2H-pyrazol-3-ol

Conditions
ConditionsYield
With quinine In chloroform at 20℃; for 4h; Solvent; Temperature; Reagent/catalyst; Michael Addition; enantioselective reaction;99%
With C33H30F6N4O3 In dichloromethane at 20℃; for 24h; Michael Addition; Inert atmosphere; enantioselective reaction;96%
With C31H39N3O9S; benzoic acid In toluene at 20℃; Inert atmosphere;95%
With C29H32N4O2S In chloroform at -30℃; for 12h; Michael Addition; enantioselective reaction;95.3%
With C40H31F6N3O2 In 1,2-dichloro-ethane at 20℃; for 24h; Catalytic behavior; Reagent/catalyst; Solvent; Michael Addition; enantioselective reaction;93%
1-chloro-4-(2-nitrovinyl)benzene
706-07-0

1-chloro-4-(2-nitrovinyl)benzene

edaravone
89-25-8

edaravone

(R)-4-(1-(4-chlorophenyl)-2-nitroethyl)-3-methyl-1-phenyl-1H-pyrazol-5-ol
1451195-14-4

(R)-4-(1-(4-chlorophenyl)-2-nitroethyl)-3-methyl-1-phenyl-1H-pyrazol-5-ol

Conditions
ConditionsYield
With quinine In chloroform at 20℃; for 4h; Michael Addition; enantioselective reaction;99%
With C31H39N3O9S; benzoic acid In toluene at 20℃; for 12h; Schlenk technique; Inert atmosphere; enantioselective reaction;99%
With C40H31F6N3O2 In 1,2-dichloro-ethane at 20℃; for 18h; Michael Addition; enantioselective reaction;95%
With C29H32N4O2S In chloroform at -30℃; for 12h; Michael Addition; enantioselective reaction;93.7%
With C31H39N3O9S; benzoic acid In toluene at 20℃; Inert atmosphere;
terephthalaldehyde,
623-27-8

terephthalaldehyde,

edaravone
89-25-8

edaravone

4,4'-(1,4-phenylenebis(methanylylidene))bis(3-methyl-1-phenyl-1H-pyrazol)-5(4H)-one
306765-12-8

4,4'-(1,4-phenylenebis(methanylylidene))bis(3-methyl-1-phenyl-1H-pyrazol)-5(4H)-one

Conditions
ConditionsYield
With sulfuric acid-modified polyethyleneglycol-6000 In neat (no solvent) at 70℃; for 0.05h; Knoevenagel Condensation; Green chemistry;99%
3-nitro-β-nitrostyrene
882-26-8

3-nitro-β-nitrostyrene

edaravone
89-25-8

edaravone

(R)-3-methyl-4-(2-nitro-1-(3-nitrophenyl)ethyl)-1-phenyl-1H-pyrazol-5-ol
1451195-21-3

(R)-3-methyl-4-(2-nitro-1-(3-nitrophenyl)ethyl)-1-phenyl-1H-pyrazol-5-ol

Conditions
ConditionsYield
With quinine In chloroform at 20℃; for 6h; Michael Addition; enantioselective reaction;99%
With C29H32N4O2S In chloroform at -30℃; for 18h; Michael Addition; enantioselective reaction;93.2%
With C40H31F6N3O2 In 1,2-dichloro-ethane at 20℃; for 24h; Michael Addition; enantioselective reaction;92%
2-cyclohexyl-1-nitroethene
50598-92-0

2-cyclohexyl-1-nitroethene

edaravone
89-25-8

edaravone

(R)-4-(1-cyclohexyl-2-nitro-ethyl)-5-methyl-2-phenyl-2H-pyrazol-3-ol
1451195-27-9

(R)-4-(1-cyclohexyl-2-nitro-ethyl)-5-methyl-2-phenyl-2H-pyrazol-3-ol

Conditions
ConditionsYield
With quinine In chloroform at 20℃; for 12h; Michael Addition; enantioselective reaction;99%
nitrostyrene
5153-67-3

nitrostyrene

edaravone
89-25-8

edaravone

(R)-5-methyl-4-(2-nitro-1-phenylethyl)-2-phenyl-2H-pyrazol-3-ol
1440200-00-9

(R)-5-methyl-4-(2-nitro-1-phenylethyl)-2-phenyl-2H-pyrazol-3-ol

Conditions
ConditionsYield
With C31H39N3O9S; benzoic acid In toluene at 20℃; for 12h; Reagent/catalyst; Solvent; Time; Schlenk technique; Inert atmosphere; enantioselective reaction;99%
Stage #1: nitrostyrene With (S)-3-(3,5-bis(trifluoromethyl)phenylamino)-4-(1-phenyl-2-(piperidin-1-yl)ethylamino)cyclobut-3-ene-1,2-dione In 1,2-dichloro-ethane for 0.166667h; Michael Addition; Inert atmosphere;
Stage #2: edaravone In 1,2-dichloro-ethane at 20℃; for 24h; Michael Addition; Inert atmosphere; enantioselective reaction;
n/a
1-naphthaldehyde
66-77-3

1-naphthaldehyde

edaravone
89-25-8

edaravone

4,4'-(naphthalen-1-ylmethanediyl)bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)
1433750-55-0

4,4'-(naphthalen-1-ylmethanediyl)bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)

Conditions
ConditionsYield
With 2-carbamoylhydrazine-1-sulfonic acid In neat (no solvent) at 60℃; for 0.75h; Reagent/catalyst; Green chemistry;99%
With zinc(II) oxide In ethanol; water for 0.5h; Catalytic behavior; Reflux;93%
Stage #1: 1-naphthaldehyde; 3-methyl-1-phenylpyrazolin-5-(4H)-one With zinc(II) oxide In ethanol; water Knoevenagel Condensation; Reflux; Green chemistry;
Stage #2: With zinc(II) oxide In ethanol; water Michael Addition; Reflux; Green chemistry;
90%
3-nitro-2H-1-benzopyran
92210-53-2

3-nitro-2H-1-benzopyran

edaravone
89-25-8

edaravone

C19H17N3O4

C19H17N3O4

Conditions
ConditionsYield
With quinine In dichloromethane at -15℃; for 96h; Catalytic behavior; Solvent; Temperature; Reagent/catalyst; Michael Addition; enantioselective reaction;99%
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