Product Name : Amantadine Hcl CAS NO: 665-66-7 MF: C10H15NH2.HCL Molecular weight: 187.71 Appearance: White crystalline powder Content: 99% Usage Of Amantadine Hcl 1) As Anti-virus medicine Used to make intermediate of anti-virus medicine
Cas:665-66-7
Min.Order:100 Kilogram
Negotiable
Type:Trading Company
inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
Cas:665-66-7
Min.Order:1 Metric Ton
Negotiable
Type:Manufacturers
inquirySICHUAN ZHONGBANG with its subsidiaries LUZHOU FUBANG& LUZHOU DAZHOU are specializing in the research, development, manufacturing and trade of fine chemicals, pesticide intermediates and pharmaceutical intermediates.
Cas:665-66-7
Min.Order:0 Metric Ton
FOB Price: $18.0
Type:Manufacturers
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:665-66-7
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryItems Standard Result Appearance White crystals or crystalliine powder Complies Identification In
Cas:665-66-7
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Manufacturers
inquiryAdamantanamine hydrochloride CAS 665-66-7 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals i
Cas:665-66-7
Min.Order:25 Kilogram
FOB Price: $10.0
Type:Trading Company
inquiryhigh quality Located in Zhengdong New District, Zhengzhou of Henan province, Henan Allgreen Chemical Co.,Ltd is comprehensive high-tech modern enterprises integrating professional R&D, production and sales. Strong technical force, with a long
Cas:665-66-7
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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Cas:665-66-7
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
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Min.Order:1 Kilogram
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Type:Manufacturers
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Cas:665-66-7
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryHebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car
Cas:665-66-7
Min.Order:1 Metric Ton
FOB Price: $1.0 / 2.0
Type:Trading Company
inquiryName:1-Adamantanamine hydrochloride CAS NO:665-66-7 Grade:Medical scientific research and export Molecular formula:C10H17N Molecular weight:151.2487 Product Quality 12 years of chemical raw materials Mature operation of the industry Syst
Cas:665-66-7
Min.Order:25 Kilogram
FOB Price: $2.0 / 3.0
Type:Other
inquiryTIANFUCHEM--665-66-7--2-Bromoacetophenone in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business relation
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Min.Order:1 Metric Ton
FOB Price: $2000.0
Type:Lab/Research institutions
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Cas:665-66-7
Min.Order:1 Kilogram
FOB Price: $0.9 / 1.0
Type:Lab/Research institutions
inquiryHebei Nengqian Chemical Import and Export Co., LTD.. is located in xingtai City, Hebei Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutica
Cas:665-66-7
Min.Order:1 Gram
FOB Price: $12.0 / 15.0
Type:Trading Company
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Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryChemical Name: Amantadine Hydrochloride Synonyms: 1-Adamantanamine hydrochloride; Amantadine HCl CAS No.: 665-66-7 Molecular Formula: C10H15NH2HCl Purity: 98.0-102.0% Properties: white crystal powder, odourless; soluble in water, ethano
Cas:665-66-7
Min.Order:1 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryAppearance:White Crystalline solid Storage:Room temperature Package:25kg/drum Application:Antiviral API Transportation:Express/Sea/Air Port:Any port in china
Cas:665-66-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:665-66-7
Min.Order:10 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:665-66-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:665-66-7
Min.Order:10 Gram
FOB Price: $2.22
Type:Trading Company
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Cas:665-66-7
Min.Order:1 Kilogram
FOB Price: $30.0
Type:Trading Company
inquiry1-Adamantanamine hydrochloride CAS: 665-66-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality org
Cas:665-66-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
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Cas:665-66-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct Detail Minimum Order Qty. 10 Gram
Cas:665-66-7
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
Cas:665-66-7
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
1-Adamantanamine hydrochloride CAS: 665-66-7 Specification mp >300 °c(lit.) storage temp. -20°c freezer solubility h2o: 50 mg/ml water solubility soluble sensitive hygroscopic
Cas:665-66-7
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Cas:665-66-7
Min.Order:1 Kilogram
FOB Price: $70.0 / 90.0
Type:Lab/Research institutions
inquiryConditions | Yield |
---|---|
With hydroxylamine hydrochloride In ethanol for 2h; Reflux; | 100% |
With hydrogenchloride In water; toluene at 0 - 20℃; for 1h; Product distribution / selectivity; | |
With hydrogenchloride In diethyl ether |
1-Azidoadamantane
amantadine hydrochloride
Conditions | Yield |
---|---|
With propan-1-ol; 2,2'-azobis(isobutyronitrile); phenylsilane; bis(tri-n-butyltin)oxide In benzene Reduction; Heating; | 99% |
2,2,2-trichloroethyl (adamantan-1-yl)carbamate
amantadine hydrochloride
Conditions | Yield |
---|---|
Stage #1: 2,2,2-trichloroethyl 1-adamantylcarbamate With acetic acid; zinc Stage #2: With acetyl chloride In methanol Heating; | 99% |
Conditions | Yield |
---|---|
Stage #1: N-(1-adamantyl)acetamide With sodium heptadecanoic acid; β‐cyclodextrin; sodium hydroxide In ethanol; water for 20h; Reflux; Stage #2: With hydrogenchloride In water at 70℃; | 96.5% |
Stage #1: N-(1-adamantyl)acetamide With propylene glycol; potassium hydroxide In water at 125 - 130℃; for 8h; Green chemistry; Stage #2: With hydrogenchloride In dichloromethane; water at 55 - 60℃; for 1h; Temperature; Time; Green chemistry; | 82% |
Stage #1: N-(1-adamantyl)acetamide With methanol; water; sodium hydroxide at 145℃; for 8h; Autoclave; Stage #2: With hydrogenchloride In dichloromethane; water at 50℃; for 0.5h; Autoclave; | 82.2% |
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water at 85 - 90℃; for 1h; | 93% |
Conditions | Yield |
---|---|
Stage #1: 1-nitroadamantane With iron(III) chloride hexahydrate; hydrazine hydrate In diethyl ether; ethanol at 40℃; Inert atmosphere; Stage #2: With hydrogenchloride In water at 70℃; for 0.5h; | 89.5% |
Stage #1: 1-nitroadamantane With C36H56Cl3CrN2O; magnesium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In tetrahydrofuran at 60℃; for 24h; Inert atmosphere; Schlenk technique; Stage #2: With hydrogenchloride In tetrahydrofuran; water; ethyl acetate at 20℃; | 83% |
adamantylmagnesium bromide
amantadine hydrochloride
Conditions | Yield |
---|---|
Stage #1: adamantylmagnesium bromide With N,N,N,N,N,N-hexamethylphosphoric triamide; copper(I) cyanide*lithium chloride; 4,4'-bis(4-trifluoromethyl)benzophenone O-methylsulfonyloxime In tetrahydrofuran at 0℃; for 1h; Substitution; Stage #2: With hydrogenchloride In water; acetone at 25℃; for 0.5h; Hydrolysis; | 82% |
Multi-step reaction with 2 steps 1: chlorobenzene; diethyl ether / 0.5 h / 0 °C 2: 334 mg / aq. HCl / ethanol / 10 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: CuCN*2LiCl / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.5 h / 0 °C 2: aq. HCl View Scheme |
Conditions | Yield |
---|---|
Stage #1: 1-Adamantyl bromide With urea at 180 - 240℃; Stage #2: With hydrogenchloride In water Temperature; | 49.7% |
1-(Chloroamino)adamantane
A
N,N-dichloro-adamantan-1-amine
B
amantadine hydrochloride
Conditions | Yield |
---|---|
silica gel In methanol; dichloromethane disproportionation; Yields of byproduct given; |
amantadine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride Yield given; |
amantadine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol for 10h; Heating; | 334 mg |
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: nitric acid / 0.5 h / 25 - 30 °C 2: acetic acid / 0.5 h / 125 °C 3: acetic acid; nitric acid / water / 125 °C 4: sodium hydroxide / water 5: hydrogenchloride / diethyl ether View Scheme | |
Multi-step reaction with 2 steps 1.1: Nitrogen dioxide; ozone / 0.5 h / -78 - 30 °C 2.1: iron(III) chloride hexahydrate; hydrazine hydrate / ethanol; diethyl ether / 40 °C / Inert atmosphere 2.2: 0.5 h / 70 °C View Scheme |
1-nitroxyadamantane
amantadine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: acetic acid / 0.5 h / 125 °C 2: acetic acid; nitric acid / water / 125 °C 3: sodium hydroxide / water 4: hydrogenchloride / diethyl ether View Scheme |
1-(carbamoylamino)adamantne
amantadine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: acetic acid; nitric acid / water / 125 °C 2: sodium hydroxide / water 3: hydrogenchloride / diethyl ether View Scheme | |
With hydrogenchloride; pyrographite In water at 70℃; for 1h; pH=3 - 4; Industrial scale; | 6.4 kg |
amantadine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide / water 2: hydrogenchloride / diethyl ether View Scheme |
Conditions | Yield |
---|---|
Stage #1: 1-acetyladamantane With tetrabutylammomium bromide; sodium hydroxide In water; ethylene glycol at 40 - 190℃; for 12h; Autoclave; Stage #2: With hydrogenchloride In water; ethylene glycol pH=4; |
adamantane
A
amantadine hydrochloride
B
adamantan-2-amine hydrochloride
Conditions | Yield |
---|---|
Stage #1: adamantane With methanol; cerium(III) chloride; di-tert-butyl-diazodicarboxylate; tetrabutyl-ammonium chloride In acetonitrile at 20℃; for 10h; Irradiation; Inert atmosphere; Sealed tube; Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; for 1h; Reagent/catalyst; Further stages; |
Trimethyl orthoacetate
amantadine hydrochloride
N-(1-adamantyl)acetamide
Conditions | Yield |
---|---|
In methanol at 135℃; for 0.25h; Microwave irradiation; | 100% |
2,3,4-trifluorophenyl isocyanate
amantadine hydrochloride
1-(adamantan-1-yl)-3-(2,3,4-trifluorophenyl)urea
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; Inert atmosphere; | 100% |
2,2'-dithiodibenzoic acid dichloride
amantadine hydrochloride
N,N'-bis(1-adamantyl)-2,2'-dithiodibenzamide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 5.5h; | 98% |
With triethylamine In dichloromethane at -15℃; for 0.25h; |
amantadine hydrochloride
alpha cyclodextrin
poly(ethylene glycol) 3500, bis[N-(1-adamantyl)aminocarbonyl]-terminated, inclusion complex with α-cyclodextrin, prepared with 1-adamantylamine and proton sponge
Conditions | Yield |
---|---|
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate In N,N-dimethyl-formamide at 4℃; | 95% |
Benzyl isothiocyanate
amantadine hydrochloride
1-(adamantane-2-yl)-3-benzylthiourea
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 80℃; for 8h; | 95% |
Conditions | Yield |
---|---|
With sodium carbonate In ethanol for 15h; Heating; | 94% |
Conditions | Yield |
---|---|
With sodium chloride; sodium hydroxide In water | 94% |
With sodium hydroxide In water | |
With sodium hydroxide In dichloromethane; water |
4-((3-formyl-4-hydroxyphenyl)diazenyl)benzenesulfonamide
amantadine hydrochloride
Conditions | Yield |
---|---|
With acetic acid Reflux; | 94% |
2-hydroxy-5-(p-chlorophenylazo)benzaldehyde
amantadine hydrochloride
Conditions | Yield |
---|---|
With acetic acid Reflux; | 94% |
2,4-Dinitrofluorobenzene
amantadine hydrochloride
N-(2,4-dinitrophenyl)adamantan-1-amine
Conditions | Yield |
---|---|
With triethylamine In acetonitrile for 48h; Reflux; Darkness; | 93% |
With potassium carbonate; triethylamine In acetonitrile for 48h; pH=8 - 9; Darkness; | 50% |
Boc-Glu-OBn
amantadine hydrochloride
N-(tert-butyloxycarbonyl)-L-glutamic acid α-benzyl ester γ-(1-adamantylamide)
Conditions | Yield |
---|---|
With diphenylphosphoranyl azide; diethylamine In N,N-dimethyl-formamide at 0 - 25℃; for 21h; | 92% |
amantadine hydrochloride
phenyl isothiocyanate
1-(adamantane-2-yl)-3-phenylthiourea
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 80℃; for 8h; | 92% |
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 80℃; for 8h; | 92% |
Conditions | Yield |
---|---|
With sulfuric acid; nitric acid at 10 - 15℃; | 90% |
With sulfuric acid; nitric acid at 0 - 10℃; for 2h; | 81% |
Stage #1: amantadine hydrochloride With sulfuric acid; nitric acid at 0 - 20℃; Inert atmosphere; Stage #2: With sodium hydroxide In water | 72% |
Conditions | Yield |
---|---|
With aq. HCl In water stirring mixture of adamantane deriv., vanadium compd., water and DMF for few sec. at room temp., adjusting pH to 3 by addn. of 0.1 M aqueous HCl; filtration, keeping in air at room temp. for 2 w, elem. anal.; | 90% |
amantadine hydrochloride
N,N'-di(tert-butylcarbamate)adamantylamino-D-histidine amide
Conditions | Yield |
---|---|
With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; trimethylamine In dichloromethane at 20℃; Cooling with ice; | 90% |
Conditions | Yield |
---|---|
In hydrogenchloride; methanol adamantan-1-aminium chloride, 18-crown-6 were dissolved in MeOH, CuCl2 was added followed by concd. aq. HCl; filtered, slow evapd. at room temp., elam. anal.; | 90% |
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