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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min -----------------------------------------------------------------------------------------------

High purity Various Specifications topiramate CAS:97240-79-4

Cas:97240-79-4

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Hefei Zhaobo Technology Co., Ltd.

Topiramate CAS 97240-79-4 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control syste

Topiramate CAS 97240-79-4

Cas:97240-79-4

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Topiramate

Cas:97240-79-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

Description 1)Product Name: Topiramate 2)CAS:97240-79-4 3)Molecular Formula:C12H21NO8S 4)Molecular Weight:339.36 5

CAS:97240-79-4 Topiramate factory sales

Cas:97240-79-4

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Topiramate manufacturer with low price

Cas:97240-79-4

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Topiramate Cas 97240-79-4 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Powder Storage:2-8°C Package:1kg/foil bag, 25kg/drum or as you requir

Wholesale high quality Topiramate Cas 97240-79-4 with specialized factory

Cas:97240-79-4

Min.Order:1 Gram

FOB Price: $135.0

Type:Trading Company

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Hefei TNJ chemical industry co.,ltd

Specifications 97240-79-4 Topiramate Topiramate in stock High quality Topiramate Topiramate powder Appearance:White to off-white powder Storage:dry environment Package:25kg/drum or as your needs Application:Central Nervous System Agents Tra

Topiramate 97240-79-4

Cas:97240-79-4

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Topiramate

Cas:97240-79-4

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Topiramate

Cas:97240-79-4

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Topiramate 97240-79-4 GMP Manufacturer

Cas:97240-79-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.

Customer services: Custom synthesis(mg to kg scale) Reference compounds Building blocks and scaffolds Synthesis route optimization Appearance:whilt powder Storage:cool and dryer Package:durm Applicati

topiramate CAS NO.97240-79-4

Cas:97240-79-4

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Topiramate

Cas:97240-79-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Topiramate

Cas:97240-79-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Topiramate CAS NO:97240-79-4 Grade:Medical scientific research and export Molecular formula:C12H21NO8S Molecular weight: 339.37 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Dat

Topiramate / CAS:97240-79-4 / raw material/ high-quality

Cas:97240-79-4

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Topiramate Basic information Broad-spectrum anti-epileptic drugs Pharmacological effects Pharmacokinetics Dosage Clinical evaluationAdverse reactions and precautions Chemical Properties Product Name:

TIANFU-CHEM CAS:97240-79-4 Topiramate

Cas:97240-79-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Topiramate

Cas:97240-79-4

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 97240-79-4 with best quality

Cas:97240-79-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Topiramate/ LIDE PHARMA- Factory supply / Best price

Cas:97240-79-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Name Topiramate Synonyms McN-4853; RWJ-17021; 2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate Molecular Formula C12H21NO8S Molecular Weight 339.36 CAS Reg

Toiramate

Cas:97240-79-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White crystal Storage:Store in sealed containers at cool & d

Topiramate Pharmaceutical Raw Materials CAS 97240-79-4 for Seizures

Cas:97240-79-4

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate

High purity Topiramate 99%

Cas:97240-79-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Hangzhou Maytime Bio-Tech Co.,Ltd.

HP90351 Topiramate CAS 97240-79-4 HP90351 Topiramate CAS 97240-79-4 Topiramate CAS 97240-79-4 Brand: Hyper MW: 339.36 MSDS: Avaiable MF : C12H21N

High quality Topiramate/Topamax/Tracrium/Toiramate 97240-79-4 USP (TMP)

Cas:97240-79-4

Min.Order:1 Milligram

Negotiable

Type:Other

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Broad-spectrum anti-epileptic drugs Topiramate with CAS:97240-79-4

Cas:97240-79-4

Min.Order:50 Gram

FOB Price: $26.0 / 31.5

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Topiramate CAS:97240-79-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Topiramate CAS:97240-79-4

Cas:97240-79-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful

Factory stock, favorable price CAS 97240-79-4 Topiramate

Cas:97240-79-4

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Shanxi Ankesi Biotechnology Co., Ltd

Our Advantage 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good q

Topiramate CAS 97240-79-4 Topiramate with safe delivery AKS

Cas:97240-79-4

Min.Order:1 Kilogram

FOB Price: $45.0 / 60.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Topiramate

Cas:97240-79-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Top quality Topiramate with reasonable price and fast delivery on hot selling

Cas:97240-79-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

topiramate CAS97240-79-4

Cas:97240-79-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

2,3,4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose chlorosulfonic acid ester
150609-95-3

2,3,4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose chlorosulfonic acid ester

topiramate
97240-79-4

topiramate

Conditions
ConditionsYield
With ammonia In tetrahydrofuran; hexane at 20℃; for 3h; Solvent; Temperature;96.7%
With ammonia In tetrahydrofuran; Petroleum ether at 20℃; for 3h; Solvent;95.2%
With pyridine; SULFAMIDE In 5,5-dimethyl-1,3-cyclohexadiene at 128 - 133℃; for 3h;91.1%
C15H26N2O8S

C15H26N2O8S

topiramate
97240-79-4

topiramate

Conditions
ConditionsYield
With hydrazine hydrate In ethanol at 20℃; for 1h;90%
2,3;4,5-di-O-isopropylidene-β-D-fructopyranose
20880-92-6

2,3;4,5-di-O-isopropylidene-β-D-fructopyranose

topiramate
97240-79-4

topiramate

Conditions
ConditionsYield
With pyridine; 2,2,2-trifluoro-1-(trifluoromethyl)ethyl sulfamate In dichloromethane at 30℃; for 8h;88%
With 4-methyl-morpholine; sulphamoyl chloride In di-isopropyl ether; N,N-dimethyl-formamide at 5℃; for 1h; Product distribution / selectivity; Crude product recrystalization;76%
With sulphamoyl chloride; triethylamine In di-isopropyl ether; N,N-dimethyl acetamide at 5℃; for 1h; Product distribution / selectivity; Crude product recrystalization;75%
N-benzyloxycarbonyl-2,3: 4,5-di-O-(1-methylethylidene)-β-D-fructopyranosaminosulfonates potassium salt

N-benzyloxycarbonyl-2,3: 4,5-di-O-(1-methylethylidene)-β-D-fructopyranosaminosulfonates potassium salt

topiramate
97240-79-4

topiramate

Conditions
ConditionsYield
With palladium on activated charcoal In methanol at 20℃; under 9000.9 Torr; for 3h;83%
N-[(diphenylamino)carbonyl]-2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate

N-[(diphenylamino)carbonyl]-2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate

topiramate
97240-79-4

topiramate

Conditions
ConditionsYield
With water; sodium acetate; acetic acid In acetone at 68 - 70℃; for 1 - 1.5h; pH=3.5; Product distribution / selectivity; Heating / reflux;67%
With sodium acetate; acetic acid In water; acetone at 68 - 70℃; for 1 - 1.5h; pH=3.5; Product distribution / selectivity; Heating / reflux;67%
With water In acetone at 70℃; for 2h; pH=3.5; aq. acetate buffer;
N-{[methyl(phenyl)amino]carbonyl}-2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate

N-{[methyl(phenyl)amino]carbonyl}-2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate

topiramate
97240-79-4

topiramate

Conditions
ConditionsYield
With water; sodium acetate; acetic acid In acetone at 70℃; for 2 - 2.5h; pH=3.5; Product distribution / selectivity; Heating / reflux;63%
With sodium acetate; acetic acid In water; acetone at 70℃; for 2 - 2.5h; pH=3.5; Product distribution / selectivity; Heating / reflux;63%
N-[(diethylamino)carbonyl]-2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate
876403-98-4

N-[(diethylamino)carbonyl]-2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate

topiramate
97240-79-4

topiramate

Conditions
ConditionsYield
Stage #1: N-[(diethylamino)carbonyl]-2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate With sodium hydroxide; water; acetic acid In acetone at 78 - 79℃; for 1 - 8.5h; pH=2.5 - 5; Heating / reflux;
Stage #2: With sodium hydroxide In water; acetone Product distribution / selectivity;
61%
With sodium hydroxide; acetic acid In water; acetone at 78 - 79℃; for 1 - 8.5h; pH=2.5 - 5.0; Product distribution / selectivity; Heating / reflux;61%
With water; sodium acetate; acetic acid In acetonitrile at 80℃; for 1.5 - 2h; pH=3.5; Product distribution / selectivity;
2,3-O-(1-Methylethylidene)-β-D-fructopyranose 1-sulfamate
106881-41-8

2,3-O-(1-Methylethylidene)-β-D-fructopyranose 1-sulfamate

orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

Trifluoroacetaldehyde ethyl hemiacetal
433-27-2

Trifluoroacetaldehyde ethyl hemiacetal

topiramate
97240-79-4

topiramate

Conditions
ConditionsYield
With sulfuric acid30%
2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose azidosulfate
106881-35-0

2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose azidosulfate

topiramate
97240-79-4

topiramate

Conditions
ConditionsYield
With hydrogen; 5%-palladium/activated carbon In ethyl acetate under 2844.39 - 3102.97 Torr; for 8h;
2,2,7,7,-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b,4',5'-d]pyran-3a-ylmethyl (E)-benzylidenesulfamate

2,2,7,7,-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b,4',5'-d]pyran-3a-ylmethyl (E)-benzylidenesulfamate

topiramate
97240-79-4

topiramate

Conditions
ConditionsYield
With hydrogenchloride; water In acetone at 20℃; for 1.5h; Product distribution / selectivity;
N-(2-methoxycarbonylphenyl)carbonyl-2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate
627538-01-6

N-(2-methoxycarbonylphenyl)carbonyl-2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate

topiramate
97240-79-4

topiramate

Conditions
ConditionsYield
With sodium hydroxide In DMF (N,N-dimethyl-formamide) at 20 - 80℃; for 12h; Product distribution / selectivity;
N-phenoxycarbonyl-2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate

N-phenoxycarbonyl-2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate

topiramate
97240-79-4

topiramate

Conditions
ConditionsYield
With hydrogen; palladium on activated carbon In ethanol at 20℃; under 2585.81 Torr; for 5h; Product distribution / selectivity;
topiramate base

topiramate base

topiramate
97240-79-4

topiramate

Conditions
ConditionsYield
In water; acetone at 0 - 35℃; Purification / work up;
D-Fructose
57-48-7

D-Fructose

topiramate
97240-79-4

topiramate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuric acid
2: SULFAMIDE; pyridine / 5,5-dimethyl-1,3-cyclohexadiene / 130 - 140 °C
View Scheme
D-fructose
7660-25-5

D-fructose

topiramate
97240-79-4

topiramate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: zinc(II) chloride / 2 h / 58 °C
2: sulfuryl dichloride; 1H-imidazole / dichloromethane / 2.5 h / 0 °C / Molecular sieve
3: ammonia / ethanol / 6 h / 20 °C / Green chemistry; Industrial scale
View Scheme
fructopyranose
6347-01-9

fructopyranose

topiramate
97240-79-4

topiramate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sulfuric acid / acetone / 0 - 15 °C / Inert atmosphere; Large scale
2: sulfuryl dichloride; pyridine / dichloromethane; toluene / 3 h / -10 - 20 °C
3: ammonia / tetrahydrofuran; hexane / 3 h / 20 °C
View Scheme
topiramate
97240-79-4

topiramate

2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose azidosulfate
106881-35-0

2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose azidosulfate

Conditions
ConditionsYield
With fluorosulfonyl azide; potassium hydrogencarbonate In tert-butyl methyl ether; water; N,N-dimethyl-formamide at 20℃; for 0.0833333h;99%
1-phenylpyrrolidin-2-one
4641-57-0

1-phenylpyrrolidin-2-one

topiramate
97240-79-4

topiramate

((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methyl ((E)-1-phenylpyrrolidin-2-ylidene)sulfamate

((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methyl ((E)-1-phenylpyrrolidin-2-ylidene)sulfamate

Conditions
ConditionsYield
With diazoacetic acid ethyl ester; zinc trifluoromethanesulfonate In cyclohexane for 12h; Reflux; stereoselective reaction;98%
methanol
67-56-1

methanol

topiramate
97240-79-4

topiramate

methyl D-fructopyranoside sulfamate
106881-46-3, 106881-47-4

methyl D-fructopyranoside sulfamate

Conditions
ConditionsYield
With hydrogenchloride at 23℃; for 24h;94%
ethyl iodide
75-03-6

ethyl iodide

topiramate
97240-79-4

topiramate

N-ethyl topiramate

N-ethyl topiramate

Conditions
ConditionsYield
With potassium fluoride on basic alumina In acetonitrile at 80℃; for 48h;88%
4-phthalimidobutyric acid
3130-75-4

4-phthalimidobutyric acid

topiramate
97240-79-4

topiramate

C24H30N2O11S

C24H30N2O11S

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;88%
topiramate
97240-79-4

topiramate

methyl iodide
74-88-4

methyl iodide

2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose methylsulfamate
97240-80-7

2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose methylsulfamate

Conditions
ConditionsYield
With potassium fluoride on basic alumina In acetonitrile at 80℃; for 48h;86%
topiramate
97240-79-4

topiramate

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

C15H26N2O8S

C15H26N2O8S

Conditions
ConditionsYield
With thionyl chloride In chloroform at 60℃; for 3h;80%
N-Acetylimidazole
2466-76-4

N-Acetylimidazole

topiramate
97240-79-4

topiramate

Acetyl-sulfamic acid (3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-3a-ylmethyl ester; compound with 1H-imidazole

Acetyl-sulfamic acid (3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-3a-ylmethyl ester; compound with 1H-imidazole

Conditions
ConditionsYield
In toluene for 7h; Heating;78%
1-iodo-propane
107-08-4

1-iodo-propane

topiramate
97240-79-4

topiramate

N-propyl topiramate

N-propyl topiramate

Conditions
ConditionsYield
With potassium fluoride on basic alumina In acetonitrile at 80℃; for 48h;77%
benzyl bromide
100-39-0

benzyl bromide

topiramate
97240-79-4

topiramate

A

N,N'-dibenzyl topiramate

N,N'-dibenzyl topiramate

B

N-benzyl topiramate

N-benzyl topiramate

Conditions
ConditionsYield
With potassium fluoride on basic alumina In acetonitrile at 80℃; for 36h;A 7%
B 77%
bromobenzene
108-86-1

bromobenzene

topiramate
97240-79-4

topiramate

((3aR,5aS,8aS,8bR)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methyl phenylsulfamate
106881-36-1

((3aR,5aS,8aS,8bR)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methyl phenylsulfamate

Conditions
ConditionsYield
With (1,2-dimethoxyethane)dichloronickel(II); (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 30℃; for 24h; Inert atmosphere; Irradiation; Sealed tube;73%
topiramate
97240-79-4

topiramate

1-bromomethyl-4-bromobenzene
589-15-1

1-bromomethyl-4-bromobenzene

A

N-(4-bromobenzyl)topiramate

N-(4-bromobenzyl)topiramate

B

N,N-di(4-bromobenzyl)topiramate

N,N-di(4-bromobenzyl)topiramate

Conditions
ConditionsYield
With potassium fluoride on basic alumina In acetonitrile at 80℃; for 36h;A 68%
B 11%
topiramate
97240-79-4

topiramate

(bromomethyl)pentafluorobenzene
1765-40-8

(bromomethyl)pentafluorobenzene

A

C19H22F5NO8S

C19H22F5NO8S

B

N,N-di(pentaflourobenzyl)topiramate

N,N-di(pentaflourobenzyl)topiramate

Conditions
ConditionsYield
With potassium fluoride on basic alumina In acetonitrile at 80℃; for 36h;A 64%
B 28%
ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

topiramate
97240-79-4

topiramate

C36H59NO11S

C36H59NO11S

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 6h;60%
diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

topiramate
97240-79-4

topiramate

Acetanilid
103-84-4

Acetanilid

ethyl N-phenyl-N-((E)-1-(((((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methoxy)sulfonyl)imino)ethyl)glycinate

ethyl N-phenyl-N-((E)-1-(((((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methoxy)sulfonyl)imino)ethyl)glycinate

Conditions
ConditionsYield
With zinc trifluoromethanesulfonate In cyclohexane at 90℃; for 12h;57%
topiramate
97240-79-4

topiramate

α-bromoacetophenone
70-11-1

α-bromoacetophenone

A

C20H27NO9S

C20H27NO9S

B

C28H33NO10S

C28H33NO10S

Conditions
ConditionsYield
With potassium fluoride on basic aluminaA 54%
B 33%
(S)-N-acetylphenylalanine
3618-96-0

(S)-N-acetylphenylalanine

topiramate
97240-79-4

topiramate

methyl (1-(((((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methoxy)sulfonyl)imino)ethyl)-L-phenylalaninate

methyl (1-(((((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methoxy)sulfonyl)imino)ethyl)-L-phenylalaninate

Conditions
ConditionsYield
With diazoacetic acid ethyl ester; manganese(II) perchlorate hexahydrate In cyclohexane at 90℃; for 12h; chemoselective reaction;48%
1-(Trimethylsilyloxy)cyclohexene
6651-36-1

1-(Trimethylsilyloxy)cyclohexene

topiramate
97240-79-4

topiramate

4,5-O-cyclohexylidene-2,3-O-(1-methyl-ethylidene)-β-D-fructopyranose sulfamate
106881-40-7

4,5-O-cyclohexylidene-2,3-O-(1-methyl-ethylidene)-β-D-fructopyranose sulfamate

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran for 0.0833333h;43%
topiramate
97240-79-4

topiramate

3,6-dioxa-2-thia-1-azaspiro<4.5>decane-8α,9α,10β-triol 2,2-dioxide

3,6-dioxa-2-thia-1-azaspiro<4.5>decane-8α,9α,10β-triol 2,2-dioxide

Conditions
ConditionsYield
With Amberlite IR-45 (anion-exchange resin, hydroxide form); trifluoroacetic acid for 18h; Ambient temperature;43%
topiramate
97240-79-4

topiramate

2,3-O-(1-Methylethylidene)-β-D-fructopyranose 1-sulfamate
106881-41-8

2,3-O-(1-Methylethylidene)-β-D-fructopyranose 1-sulfamate

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran at 45℃; for 3.5h;31%
berberine chloride
633-65-8

berberine chloride

topiramate
97240-79-4

topiramate

C31H35N2O11S(1+)*Cl(1-)

C31H35N2O11S(1+)*Cl(1-)

Conditions
ConditionsYield
In ethanol for 16h; Reflux;20%

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