Chengdu AstaTech Chemical Technology Co., Ltd. is a wholly-owned subsidiary of AstaTech (Chengdu) BioPharmaceutical Co., Ltd. It has overall accountability for AstaTech’s product list and sales and promotion of chemical reagents in China. The company
Cas:114772-54-2
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inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:114772-54-2
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryItems Standard Result Assay 98%min ----------------------------------------------------------------------------------------------
Cas:114772-54-2
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inquiryProduct Description Product Name 4-Bromomethyl-2-cyanobiphenyl CAS No. 114772-54-2 Appearance White powder Assay ≥99% Capacity 200mt/year Min.packing 100g
Cas:114772-54-2
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inquiry4-Bromomethyl-2-cyanobiphenyl CAS No.:114772-54-2 Name 4-Bromomethyl-2-cyanobiphenyl Synonyms 4'-Bromomethyl-2-biphenylcarbonitrile Molecular Structure Molecular Formula C14H
Cas:114772-54-2
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inquiryGood quality Good price Promptly delivery Appearance:white powder Storage:dry dondition Package:According to the demand of customer Application:intermediate Transportation:According to the demand of customer Port:shanghai
Cas:114772-54-2
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:114772-54-2
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inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:114772-54-2
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:114772-54-2
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inquiryProduct Name: 4-Bromomethyl-2-cyanobiphenyl Synonyms: 4-BroMoMethyl-2-cyanophenyl;4-BroMoMethyl-2-cyanobiphenyl, 98% 5GR;4-(2-Cyanophenyl)benzyl BroMide;4'-Bromomethylbiphenyl-2-carbonitrile 2-Cyano-4'-bromomethylbiphenyl;Br-OT
Cas:114772-54-2
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:114772-54-2
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:114772-54-2
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inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:114772-54-2
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryName: 4-Bromomethyl-2-Cyanobiphenyl Synonyms: 4-Bromomethyl-2-Biphenylcarbonitrile CAS:114772-54-2 MF: C14H10BrN Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/drum Application:Pharmaceutical in
Cas:114772-54-2
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inquiryAppearance:White crystalline powder Storage:Room temperature Package:25kg/drum Application:Pharmaceutical intermediates Transportation:Express/Sea/Air Port:Any port in china
Cas:114772-54-2
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:114772-54-2
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:114772-54-2
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inquiryHanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d
Cas:114772-54-2
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inquiryProduct :4-Bromomethyl-2-cyanobiphenyl CAS No. 114772-54-2 !--?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /--> Storage:store in sealed container Package:25kgs/fiber drum Application:As sartan intermediate Port:sh
Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:114772-54-2
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inquiry4-Bromomethyl-2-cyanobiphenyl CAS:114772-54-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality or
Cas:114772-54-2
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiry4-Bromomethyl-2-cyanobiphenyl CAS: 114772-54-2 Specification product name 4-bromomethyl-2-cyanobiphenyl cas no. 114772-54-2 appearance white powder assay ≥99% capacity 200mt/yea
Cas:114772-54-2
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:114772-54-2
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:114772-54-2
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inquiryTriumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and quality c
Cas:114772-54-2
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiry2-Cyano-4'-methylbiphenyl
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane | 96% |
With bromine In water; 1,2-dichloro-ethane at 84℃; for 0.25h; Temperature; Solvent; Irradiation; Flow reactor; | 96.3% |
With bromine In 1,2-dichloro-ethane at 70℃; for 0.5h; Reagent/catalyst; Temperature; Time; Irradiation; | 94% |
2-cyano-4-methylbiphenyl
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With 5,5-dibromohydantoin In dichloromethane at 50℃; for 0.5h; Temperature; Reagent/catalyst; Irradiation; | 94% |
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane at 100℃; for 2h; |
2-Cyano-4'-methylbiphenyl
1,2-dichloro-ethane
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With bromine In water | 89.4% |
With N-Bromosuccinimide In water | 79.6% |
2-Cyano-4'-methylbiphenyl
A
2-(4,4-dibromomethylphenyl)benzonitrile
B
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With N-Bromosuccinimide; Azo-bis(2,4-dimethyl-valeronitril) In dichloromethane at 45 - 50℃; for 2 - 5h; Industry scale; | A n/a B 82% |
With sodium bromate; hydrogen bromide In dichloromethane; water at 0 - 20℃; UV-irradiation; | A 10% B 80% |
With sodium bromate; azobis(2-cyanobutane); bromine In water; chlorobenzene at 70 - 80℃; for 6h; | A n/a B 69% |
2-Cyano-4'-methylbiphenyl
2,2'-azobis (2,4-dimethyl valeronitrile)
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With N-Bromosuccinimide In dichloromethane; water | 80.5% |
2-Cyano-4'-methylbiphenyl
chlorobenzene
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With bromine | 75% |
2-cyanobenzoic acid
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 71 percent / copper(II) oxide; potassium carbonate; potassium fluoride / palladium(II) bromide; 1,10-phenanthroline / quinoline / 24 h / 170 °C 2: 45 percent / N-bromosuccinimide; azobis(isobutyronitrile) / CCl4; cyclohexane / 18 h / 75 °C View Scheme |
ammonium 2-(aminocarbonyl)benzoate
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 72 percent / acetic anhydride; pyridine 2: 71 percent / copper(II) oxide; potassium carbonate; potassium fluoride / palladium(II) bromide; 1,10-phenanthroline / quinoline / 24 h / 170 °C 3: 45 percent / N-bromosuccinimide; azobis(isobutyronitrile) / CCl4; cyclohexane / 18 h / 75 °C View Scheme |
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tetrahydrofuran / 2 h / 20 °C 2: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 3: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: magnesium / tetrahydrofuran 2: hydrogenchloride 3: thionyl chloride / water; toluene 4: dibenzoyl peroxide View Scheme |
N-(2-hydroxy-1,1-dimethyl)-2-methoxybenzamide
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: thionyl chloride / 1 h / 25 °C 2: tetrahydrofuran / 2 h / 20 °C 3: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 4: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme |
4,4-dimethyl-2-(4'-methyl-biphenyl-2-yl)-4,5-dihydrooxazole
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 2: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride 2: thionyl chloride / water; toluene 3: dibenzoyl peroxide View Scheme |
2-Methoxybenzoic acid
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 95 percent / thionyl chloride / 18 h / 20 °C 2: CH2Cl2 / 2 h / 20 °C 3: thionyl chloride / 1 h / 25 °C 4: tetrahydrofuran / 2 h / 20 °C 5: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 6: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme |
2-Methoxybenzoyl chloride
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: CH2Cl2 / 2 h / 20 °C 2: thionyl chloride / 1 h / 25 °C 3: tetrahydrofuran / 2 h / 20 °C 4: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 5: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme |
chlorobenzene
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
In water |
2-Cyano-4'-methylbiphenyl
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
In water; chlorobenzene | |
In water; chlorobenzene |
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
tetrachloromethane
2-Cyano-4'-methylbiphenyl
dibenzoyl peroxide
B
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
azobisisobutyronitrile
2-Cyano-4'-methylbiphenyl
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With N-Bromosuccinimide In water; chlorobenzene | |
With N-Bromosuccinimide In water; chlorobenzene | |
With N-Bromosuccinimide In tetrachloromethane | |
With N-Bromosuccinimide In tetrachloromethane | |
With N-Bromosuccinimide In tetrachloromethane |
2-Cyano-4'-methylbiphenyl
dibenzoyl peroxide
B
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With N-Bromosuccinimide In tetrachloromethane |
2-Cyano-4'-methylbiphenyl
dibenzoyl peroxide
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With N-Bromosuccinimide In tetrachloromethane | |
With N-Bromosuccinimide In tetrachloromethane |
o-cyanobromobenzene
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / ethanol; water; toluene / 80 °C / Inert atmosphere 2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 40 h / 80 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / N,N-dimethyl-formamide / Inert atmosphere 2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane View Scheme | |
Multi-step reaction with 2 steps 1.1: palladium dichloride / methanol; toluene / 0.17 h / 20 °C / Inert atmosphere 1.2: 12 h / 110 °C / Inert atmosphere 2.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chlorobenzene / 6 h / 70 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / toluene / 6 h / 110 °C / Inert atmosphere 2: sodium bromate; sodium metabisulfite / ethyl acetate; water / 5 h / 0 - 25 °C View Scheme |
4-methylphenylboronic acid
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / ethanol; water; toluene / 80 °C / Inert atmosphere 2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 40 h / 80 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1.1: palladium dichloride / methanol; toluene / 0.17 h / 20 °C / Inert atmosphere 1.2: 12 h / 110 °C / Inert atmosphere 2.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chlorobenzene / 6 h / 70 °C / Inert atmosphere View Scheme |
benzaldehyde N,N-dimethylhydrazone
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 4-(dimethylamino)picolinaldehyde N,N-dibenzylhydrazone; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tetrahydrofuran / 24 h / 80 °C / Inert atmosphere 2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium phosphate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 3: magnesium bis(monoperoxyphthalate)hexahydrate / methanol / 0 h / 20 °C 4: sodium metabisulfite; sodium bromate / water; ethyl acetate / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: 4-(dimethylamino)picolinaldehyde N,N-dibenzylhydrazone; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tetrahydrofuran / 24 h / 80 °C / Inert atmosphere 2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium phosphate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 3: magnesium bis(monoperoxyphthalate)hexahydrate / methanol / 0 h / 20 °C 4: sodium metabisulfite; sodium bromate / water; ethyl acetate / 20 °C View Scheme |
2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde N,N-dimethylhydrazone
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium phosphate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 2: magnesium bis(monoperoxyphthalate)hexahydrate / methanol / 0 h / 20 °C 3: sodium metabisulfite; sodium bromate / water; ethyl acetate / 20 °C View Scheme |
4′-methyl-[1,1′-biphenyl]-2-carbaldehyde N,N-dimethylhydrazone
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: magnesium bis(monoperoxyphthalate)hexahydrate / methanol / 0 h / 20 °C 2: sodium metabisulfite; sodium bromate / water; ethyl acetate / 20 °C View Scheme |
tributyl(p-tolyl)stannane
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / N,N-dimethyl-formamide / Inert atmosphere 2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane View Scheme |
2-Chlorobenzonitrile
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: manganese(ll) chloride; chloro-trimethyl-silane / tetrahydrofuran / -5 - 0 °C / Inert atmosphere; Green chemistry 1.2: 9 h / -5 - 25 °C / Inert atmosphere; Green chemistry 2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / 80 °C / Green chemistry View Scheme |
4-tolylmagnesium chloride
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: manganese(ll) chloride; chloro-trimethyl-silane / tetrahydrofuran / -5 - 0 °C / Inert atmosphere; Green chemistry 1.2: 9 h / -5 - 25 °C / Inert atmosphere; Green chemistry 2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / 80 °C / Green chemistry View Scheme |
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Methyl 3-nitro-4-valerylaminobenzoate
4-[(2'-Cyano-biphenyl-4-ylmethyl)-pentanoyl-amino]-3-nitro-benzoic acid methyl ester
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide for 15h; Ambient temperature; | 100% |
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
ethyl butyroyl acetate
ethyl 2-<(2'-cyanobiphenyl-4-yl)methyl>-3-oxohexanoate
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; lithium chloride In tetrahydrofuran for 15h; Heating; | 98% |
With N-ethyl-N,N-diisopropylamine; lithium chloride In tetrahydrofuran for 15h; Heating; | |
With N-ethyl-N,N-diisopropylamine; lithium chloride In tetrahydrofuran for 15h; Heating; Yield given; |
L-valine benzyl ester p-toluenesulfonate salt
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
(S)-2-[(2'-cyanobiphenyl-4-ylmethyl)amino]-3-methylbutyric acid benzyl ester hydrochloride
Conditions | Yield |
---|---|
Stage #1: L-valine benzyl ester p-toluenesulfonate salt With sodium hydroxide In 5,5-dimethyl-1,3-cyclohexadiene; water at 20℃; pH=< 8.5 - 9; Large scale; Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In 5,5-dimethyl-1,3-cyclohexadiene at 60℃; for 3.41667h; Large scale; Stage #3: With hydrogenchloride In 5,5-dimethyl-1,3-cyclohexadiene; water at 72℃; for 2h; Dean-Stark; Large scale; | 98% |
Stage #1: L-valine benzyl ester p-toluenesulfonate salt; 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile With tetrabutylammomium bromide; potassium carbonate; potassium iodide In water; toluene at 50 - 55℃; for 25h; Stage #2: With hydrogenchloride In water; toluene pH=1 - 2; Product distribution / selectivity; | 90% |
Stage #1: L-valine benzyl ester p-toluenesulfonate salt; 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile With tetrabutylammomium bromide; potassium carbonate; potassium iodide In water; toluene Stage #2: With hydrogenchloride In water; toluene pH=1 - 2; Product distribution / selectivity; | 90% |
N-phenylpentanamide
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
Stage #1: N-phenylpentanamide With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.166667h; Inert atmosphere; Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere; | 98% |
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
N-(2'-cyanobiphenyl-4-ylmethyl)-N-propyl-amine
Conditions | Yield |
---|---|
96% |
methyl 4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylate hydrochloride
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
2-cyano-4'-[2"-n-propyl-4"-methyl-6"-methylcarboxylate-benzimidazole-1"-ylmethyl]biphenyl
Conditions | Yield |
---|---|
Stage #1: methyl 4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylate hydrochloride With sodium carbonate; sodium iodide In acetone Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In acetone for 15h; Product distribution / selectivity; Reflux; | 95% |
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
2-Mercaptobenzothiazole
4'-(benzothiazol-2-ylsulfanylmethyl)-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In acetonitrile at 20℃; for 1.33333h; | 94.7% |
2-(4-fluoro-benzylsulfanyl)-3H-quinazolin-4-thione
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
C29H20FN3S2
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12h; Inert atmosphere; | 94% |
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
methyl 4-hydroxylbenzoate
Conditions | Yield |
---|---|
With potassium carbonate In butanone at 78 - 80℃; for 2h; | 93.5% |
2-butyl-4-(4-fluorophenyl)-1H-imidazole-5-carbaldehyde
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
4'-[{2-butyl-4-(4-fluorophenyl)-5-formyl-1H-imidazol-1-yl}methyl]biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 4h; | 93.2% |
Ethyl 3-oxoheptanoate
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
2-(2'-Cyano-biphenyl-4-ylmethyl)-3-oxo-heptanoic acid ethyl ester
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; lithium chloride In tetrahydrofuran for 15h; Heating; | 93% |
With N-ethyl-N,N-diisopropylamine; lithium chloride In tetrahydrofuran for 15h; Heating; | |
With N-ethyl-N,N-diisopropylamine; lithium chloride In tetrahydrofuran for 15h; Heating; Yield given; |
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
(6-Butyl-2-oxo-1,2-dihydro-pyridin-3-ylmethyl)-carbamic acid tert-butyl ester
6-butyl-1-(2'-cyanobiphenyl-4-ylmethyl)-1,2-dihydro-2-oxo-3-tert-butoxycarbonylaminomethyl pyridine
Conditions | Yield |
---|---|
With n-butyllithium In tetrahydrofuran; hexane for 72h; Heating; | 92% |
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
dimethyl amine
4'-((dimethylamino)methyl)-[1,1'-biphenyl]-2-carbonitrile
Conditions | Yield |
---|---|
In diethyl ether; water at 20℃; | 92% |
8-bromo-7-(but-2-yn-1-yl)-3-methyl-2,,6-dihydro-1H-purine-2,6-dione
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 55℃; for 6h; | 92% |
benzoimidazole
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
4′-((1H-benzo[d]imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-carbonitrile
Conditions | Yield |
---|---|
Stage #1: benzoimidazole With potassium hydroxide In dimethyl sulfoxide at 100℃; for 2h; Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In dimethyl sulfoxide for 12h; | 92% |
5-methyl-3-oxo-hexanoic acid ethyl ester
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
2-(2'-Cyano-biphenyl-4-ylmethyl)-5-methyl-3-oxo-hexanoic acid ethyl ester
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; lithium chloride In tetrahydrofuran for 15h; Heating; | 91% |
2-propyl-1H-benzimidazole
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
4’-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile
Conditions | Yield |
---|---|
Stage #1: 2-propyl-1H-benzimidazole With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In N,N-dimethyl-formamide at 0 - 20℃; | 91% |
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 3h; Cooling with ice; | 70% |
Stage #1: 2-propyl-1H-benzimidazole With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h; Inert atmosphere; Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In N,N-dimethyl-formamide at 20℃; Inert atmosphere; |
quinazoline-4(3H)-thione
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
C22H15N3S
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12h; Inert atmosphere; | 91% |
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
In nitromethane for 7.5h; Heating; | 91% |
7-amino-4-(azidomethyl)-2H-chromen-2-one
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With sodium carbonate In acetone for 6h; Reflux; | 90.5% |
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide for 0.0208333h; microwave irradiation; | 90% |
Stage #1: 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With potassium carbonate; tetrabutylammomium bromide In water at 25 - 30℃; for 2h; Inert atmosphere; Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In water at 55 - 60℃; Product distribution / selectivity; | 84.2% |
With tetrabutylammomium bromide; sodium hydroxide In Isopropyl acetate at 0 - 30℃; for 12h; Solvent; | 39% |
4-amino-phenol
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide Reflux; | 90% |
4-trifluoromethylphenylamine
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide Reflux; | 90% |
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
Stage #1: 5-chloro-1,7’-dimethyl-2’-propyl-1H,3’H-2,5’-bibenzo[d]imidazole With sodium hydroxide In water; acetone for 0.5h; Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In water; acetone at 25℃; | 90% |
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
Conditions | Yield |
---|---|
With hydroxylamine hydrochloride; sodium methylate In tetrahydrofuran; methanol at 20 - 30℃; Solvent; Reagent/catalyst; Temperature; | 89.9% |
With hydroxylamine hydrochloride; sodium carbonate In dimethyl sulfoxide at 25 - 80℃; Reagent/catalyst; Solvent; Temperature; | 85.4% |
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
2-nitro-aniline
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide Reflux; | 89% |
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