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Cas:55268-74-1
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inquiry1. GMP AVALIABLE ; 2. IN STOCK 3. FAST REPLY QUALIFED ; EFFICIENCY; RESPONSIBLE Appearance:WHITE POWDER Storage:in cool Package:25kg/drum / 25kg/bag Application:active pharmaceutical ingredient Transportation:sea/air both ok Port:any
Items Standard Result Appearance A white or almost white crystalline powder White powder Identification
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inquiryBOC Sciences is committed to supplying cost-effective products and services. We provide Praziquantel (Cas No:55268-74-1). More information, please visit the website:https://www.bocsci.com/description.asp cas=55268-74-1 Package:according to the cli
1. Molecular formula: C19H24N2O2 2. Molecular weight: 312.41 3. Packing: 25kg/drum 4. Appearance: white or almost white crystalline powder 5. Melting range: 136-142℃ 6. Annual supply: 10 tons 7. Grade: pharmaceutical grade 8. Loss on drying: 0
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inquiryPraziquantel Veterinary CAS Number: 55268-74-1 Molecular Formula: C19H24N2O2 Molecular Weight: 312.41 Packing 25kg/drum Capacity 8-10 T/M Storage Keep tightly closed in light-resistant containers Application Anti-worm. It is adapt
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The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Assay: 98.5%~101.0% (USP40); Stable supply with over 20Mt annually; Appearance:White or practically white crystalline powder Storage:room temprature Package:1kg/bag, 25kg/drum Application:Anti-schistosomal; sensory transient receptor potential me
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryItems Specification Appearance White crystalline powder Identification Positive Melting Point 136 ~ 142° Loss on Drying ≤ 0.5% Residue on Ignition ≤ 0.1% Heavy Metals ≤ 20ppm Phosphate ≤ 0.05% Related Substances A≤ 0.
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inquiryName:PRAZIQUANTEL CAS NO: 55268-74-1 Grade:Medical scientific research and export Molecular formula:C19H24N2O2 Molecular weight: 312.41 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability
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inquiryPraziquantel Basic information The treatment of schistosomiasis Chemical Properties Application Production method Category Toxicity grading Acute toxicity Flammability and hazardous characteristics Storage Characteristics
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inquirycas 55268-74-1 99% Praziquantel powder Product Name: Praziquantel CAS: 55268-74-1 MF: C19H24N2O2 MW: 312.41 EINECS: 259-559-6 Appearance:white Storage:room Package:drum Applica
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inquiryName: Praziquantel Synonyms: 2-Cyclohexyl-carbonyl-1,3,4,6,7,11b-hexahydro-2H-pyrazine(2,1-a)isoquinoline-4-one CAS:55268-74-1 MF: C19H24N2O2 Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/drum
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Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
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Cas:55268-74-1
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inquiryAPIs Best price; High Quality; Superior Service; Fast delivery. Appearance:White crystalline powder Storage:Stored in a cool & dried place Package:25kg/fiber drum or according to your requirements Application:pharmaceutical ,food or oth
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inquiry4-(cyclohexanecarbonyl)-6-hydroxy-1-phenethylpiperazin-2-one
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
With hydrogenchloride at 0℃; | 95% |
With sulfuric acid | 3.0 g (95%) |
With sulfuric acid In dichloromethane at 0 - 5℃; for 4h; | 170.1 g |
4-(cyclohexanecarbonyl)-6-hydroxy-1-phenethylpiperazin-2-one
B
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
In 12N-hydrochloric acid | A 95% B n/a |
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen In methanol at 20℃; under 760.051 Torr; for 19h; Solvent; Inert atmosphere; | 93% |
cyclohexanylcarbonyl chloride
2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
With triethylamine In 1,2-dimethoxyethane for 15h; Ambient temperature; | 90% |
With sodium carbonate In dichloromethane for 2h; Ambient temperature; | 85% |
With triethylamine In 1,2-dimethoxyethane for 20h; Ambient temperature; | 70% |
1-[2-(2-bromophenyl)ethyl]-4-(cyclohexylcarbonyl)-1,3,4-trihydropyrazin-2-one
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In toluene for 16h; Heating; | 90% |
Multi-step reaction with 2 steps 1: caesium carbonate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere 2: palladium on activated charcoal; hydrogen / methanol / 19 h / 20 °C / 760.05 Torr / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: caesium carbonate; tetrakis(triphenylphosphine) palladium(0) / 2-methyltetrahydrofuran / 22 h / 80 °C / Inert atmosphere 2: palladium on activated charcoal; hydrogen / methanol / 19 h / 20 °C / 760.05 Torr / Inert atmosphere View Scheme |
N-(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)cyclohexanecarboxylic acid amide
chloroacetyl chloride
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane at 20 - 25℃; for 0.7h; | 88% |
Stage #1: N-(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)cyclohexanecarboxylic acid amide; chloroacetyl chloride With sodium hydroxide In dichloromethane for 0.5h; Stage #2: With N-benzyl-N,N,N-triethylammonium chloride In dichloromethane for 2h; Reflux; | 81% |
Stage #1: N-(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)cyclohexanecarboxylic acid amide; chloroacetyl chloride With sodium hydroxide In dichloromethane at 20℃; for 0.5h; Stage #2: With benzyltrimethylammonium chloride In dichloromethane for 2h; Reflux; | 78% |
Stage #1: N-(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)cyclohexanecarboxylic acid amide; chloroacetyl chloride With sodium hydroxide In dichloromethane at 0℃; for 0.5h; Stage #2: With tetrabutylammomium bromide In dichloromethane for 3h; Reflux; | 68% |
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water Inert atmosphere; | 56% |
cyclohexanylcarbonyl chloride
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
Stage #1: C14H22N2O3*0.5H2O4S at 35 - 45℃; for 10h; Stage #2: cyclohexanylcarbonyl chloride With lithium hydroxide In water at 5℃; for 5h; | 86.5% |
1-Cyclohexylcarbonylaminomethyl-2-chloracetyl-1,2,3,4-tetrahydro-isochinolin
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In benzene at 80℃; for 0.7h; | 86% |
cyclohexanylcarbonyl chloride
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
Stage #1: C14H22N2O3*H3O4P With phosphoric acid at 10 - 20℃; for 12h; Stage #2: cyclohexanylcarbonyl chloride With calcium bicarbonate In water at 0℃; for 5h; | 86% |
cyclohexanylcarbonyl chloride
N-2-phenylethyl 2-N-(2,2-dimethoxyethylamino)acetamide hydrochloride
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
Stage #1: N-2-phenylethyl 2-N-(2,2-dimethoxyethylamino)acetamide hydrochloride With sulfuric acid In dichloromethane at 5 - 20℃; for 3.5h; Cooling with ice; Industrial scale; Stage #2: cyclohexanylcarbonyl chloride With sodium carbonate at 5 - 20℃; for 2.5h; Reagent/catalyst; Solvent; Temperature; Industrial scale; | 85.1% |
N-(2,2-dimethoxyethyl)-N-(2-oxo-2-(2-phenethylamino)-ethyl)cyclohexanecarboxamide
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
With methanesulfonic acid In 1,2-dichloro-ethane for 6h; Heating; | 85% |
Stage #1: N-(2,2-dimethoxyethyl)-N-(2-oxo-2-(2-phenethylamino)-ethyl)cyclohexanecarboxamide With methanesulfonic acid at 0 - 70℃; for 6h; Pictet-Spengler cyclisation; Stage #2: With water; sodium hydroxide pH=8; Pictet-Spengler cyclisation; Cooling with ice; | 65% |
Multi-step reaction with 2 steps 1: 95 percent / methanesulfonic acid / CH2Cl2 / 3 h / Ambient temperature 2: conc. H2SO4 / 3 h / Ambient temperature View Scheme |
cyclohexanylcarbonyl chloride
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
Stage #1: C14H22N2O3*H2O4S With sulfuric acid at 0 - 5℃; for 10h; Stage #2: cyclohexanylcarbonyl chloride With sodium carbonate In water at 0℃; for 4.5h; | 85% |
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane at 20℃; for 10h; Reagent/catalyst; Solvent; Temperature; Cooling with ice; | 76.8% |
N-(2,2-diethoxy)ethyl-N-2-phenylethyl 2-N-cyclohexylcarbonylaminoacetamide
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
With methanesulfonic acid In dichloromethane for 48h; Heating; | 73% |
Multi-step reaction with 2 steps 1: 91 percent / methanesulfonic acid / CH2Cl2 / 3 h / Ambient temperature 2: conc. H2SO4 / 3 h / Ambient temperature View Scheme |
cyclohexanylcarbonyl chloride
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
Stage #1: C14H22N2O3*(x)ClH at 10 - 15℃; for 8h; Stage #2: cyclohexanylcarbonyl chloride With calcium hydroxide In water at 10℃; for 4h; | 70.9% |
4-(cyclohexylcarbonyl)-3,4-dihydro-1-(2-phenylethyl)-2(1H)-pyrazinone
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
With sulfuric acid at 20℃; for 3h; | 70% |
With sulfuric acid for 3h; Ambient temperature; Yield given; |
cyclohexanecarboxylic acid {[(2-ethoxy-2-(polystyryl)oxy-ethyl)-phenethyl-carbamoyl]-methyl}-amide, via coupling with (cyclohexanecarbonyl-amino)-acetic acid
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
With methanesulfonic acid In nitromethane at 60℃; for 16h; | 57% |
Cyclohexanecarboxylic acid bicyclo[4.2.0]octa-1,3,5-trien-7-ylmethyl-[(methoxymethyl-carbamoyl)-methyl]-amide
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
at 400 - 425℃; for 8h; | 49% |
N-(2-phenylethyl)-N-(cyanomethyl)amide of cyclohexylcarbonylglycine
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
With formic acid; sulfuric acid; nickel 1.) water, reflux, 1 h, 2.) 20 deg C, 3 h; Yield given. Multistep reaction; | |
Multi-step reaction with 2 steps 1: 53 percent / formic acid, Raney Ni / H2O / 1 h / Heating 2: 70 percent / conc. H2SO4 / 3 h / 20 °C View Scheme |
(cyclohexanecarbonyl-amino)-acetic acid
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 88 percent / PyBroP; 1-hydroxy-7-azabenzotriazole; DIPEA / CH2Cl2 / 48 h / 20 °C 2: 76 percent / tin(II) trifluoromethanesulfonate / acetone / 48 h / 40 °C 3: 90 percent / AIBN; Bu3SnH / toluene / 16 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: 1.) dicyclohexylcarbodiimide / 1.) CHCl3, 20 deg C, 30 min, 2.) CHCl3, 20 deg C, 76 h 2: 53 percent / formic acid, Raney Ni / H2O / 1 h / Heating 3: 70 percent / conc. H2SO4 / 3 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: 1.) dicyclohexylcarbodiimide / 1.) CHCl3, 20 deg C, 30 min, 2.) CHCl3, 20 deg C, 76 h 2: 1.) Raney Ni, formic acid, 2.) conc. H2SO4 / 1.) water, reflux, 1 h, 2.) 20 deg C, 3 h View Scheme |
2-(2-bromophenyl)ethanamine
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 40 percent / NaBH(OAc)3 / 1,2-dichloro-ethane; various solvent(s) / 3 h / 20 °C 2: 88 percent / PyBroP; 1-hydroxy-7-azabenzotriazole; DIPEA / CH2Cl2 / 48 h / 20 °C 3: 76 percent / tin(II) trifluoromethanesulfonate / acetone / 48 h / 40 °C 4: 90 percent / AIBN; Bu3SnH / toluene / 16 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: 68 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt; DMAP / CH2Cl2 / 16 h / 20 °C 2: 60 percent / tin(II) trifluoromethanesulfonate / acetone / 40 °C 3: 90 percent / AIBN; Bu3SnH / toluene / 16 h / Heating View Scheme |
phenylmethyl 2-(cyclohexylcarbonylamino)acetate
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 98 percent / H2 / Pd/C / aq. ethanol / 1.5 h 2: 88 percent / PyBroP; 1-hydroxy-7-azabenzotriazole; DIPEA / CH2Cl2 / 48 h / 20 °C 3: 76 percent / tin(II) trifluoromethanesulfonate / acetone / 48 h / 40 °C 4: 90 percent / AIBN; Bu3SnH / toluene / 16 h / Heating View Scheme |
(2,2-dimethoxyethyl)-[2-(2-bromophenyl)ethyl]amine
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 88 percent / PyBroP; 1-hydroxy-7-azabenzotriazole; DIPEA / CH2Cl2 / 48 h / 20 °C 2: 76 percent / tin(II) trifluoromethanesulfonate / acetone / 48 h / 40 °C 3: 90 percent / AIBN; Bu3SnH / toluene / 16 h / Heating View Scheme |
2-[N-(2,2-dimethoxyethyl)cyclohexylcarbonylamino]acetic acid
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 68 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt; DMAP / CH2Cl2 / 16 h / 20 °C 2: 60 percent / tin(II) trifluoromethanesulfonate / acetone / 40 °C 3: 90 percent / AIBN; Bu3SnH / toluene / 16 h / Heating View Scheme |
phenylmethyl 2-[N-(2,2-dimethoxyethyl)cyclohexylcarbonylamino]acetate
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 98 percent / H2 / Pd/C / aq. ethanol 2: 68 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt; DMAP / CH2Cl2 / 16 h / 20 °C 3: 60 percent / tin(II) trifluoromethanesulfonate / acetone / 40 °C 4: 90 percent / AIBN; Bu3SnH / toluene / 16 h / Heating View Scheme |
N-(2,2-dimethoxyethyl)-N-(2-oxo-2-(2-(2-bromophenyl)ethylamino)ethyl)cyclohexanecarboxamide
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 60 percent / tin(II) trifluoromethanesulfonate / acetone / 40 °C 2: 90 percent / AIBN; Bu3SnH / toluene / 16 h / Heating View Scheme |
N-(2,2-dimethoxyethyl)-N-[2-(2-bromophenyl)ethyl]-2-(cyclohexylcarbonylamino)acetamide
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 76 percent / tin(II) trifluoromethanesulfonate / acetone / 48 h / 40 °C 2: 90 percent / AIBN; Bu3SnH / toluene / 16 h / Heating View Scheme |
Cyclohexanecarboxylic acid
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 61 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 4-dimethylaminopyridine / CH2Cl2 / 16 h / 20 °C 2: 98 percent / H2 / Pd/C / aq. ethanol / 1.5 h 3: 88 percent / PyBroP; 1-hydroxy-7-azabenzotriazole; DIPEA / CH2Cl2 / 48 h / 20 °C 4: 76 percent / tin(II) trifluoromethanesulfonate / acetone / 48 h / 40 °C 5: 90 percent / AIBN; Bu3SnH / toluene / 16 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1: 61 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 4-dimethylaminopyridine / CH2Cl2 / 16 h / 20 °C 2: 98 percent / H2 / Pd/C / aq. ethanol / 1.5 h 3: 88 percent / PyBroP; 1-hydroxy-7-azabenzotriazole; DIPEA / CH2Cl2 / 48 h / 20 °C 4: 76 percent / tin(II) trifluoromethanesulfonate / acetone / 48 h / 40 °C 5: 90 percent / AIBN; Bu3SnH / toluene / 16 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1: 82 percent / PyBroP; 1-hydroxy-7-azabenzotriazole; DIPEA / CH2Cl2 / 16 h / 20 °C 2: 98 percent / H2 / Pd/C / aq. ethanol 3: 68 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt; DMAP / CH2Cl2 / 16 h / 20 °C 4: 60 percent / tin(II) trifluoromethanesulfonate / acetone / 40 °C 5: 90 percent / AIBN; Bu3SnH / toluene / 16 h / Heating View Scheme |
N-(2-phenylethyl)aminoacetaldehyde diethyl acetal
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) NEt3 / 1.) CH2Cl2, 0 deg C, 1 h; 2.) CH2Cl2, reflux, 7 h 2: 91 percent / methanesulfonic acid / CH2Cl2 / 3 h / Ambient temperature 3: conc. H2SO4 / 3 h / Ambient temperature View Scheme |
N,N-dimethyl-formamide
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
Stage #1: N,N-dimethyl-formamide With trichlorophosphate at 20℃; for 1h; Stage #2: 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one at 60℃; for 5h; Vilsmeier formylation; Stage #3: With perchloric acid In methanol | 95% |
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one
Conditions | Yield |
---|---|
With hydrogenchloride In water Reflux; | 91.2% |
With hydrogenchloride In ethanol for 60h; Reflux; | 83% |
Stage #1: 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one With hydrogenchloride; water for 24h; Reflux; Stage #2: With sodium hydroxide In water regioselective reaction; | 80% |
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In dichloromethane for 168h; Ambient temperature; | 81% |
Multi-step reaction with 2 steps 1: 38 percent / sulfur / 2 h / 180 °C 2: 73 percent / 85percent MCPBA / CH2Cl2 View Scheme |
4-methoxy-benzaldehyde
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
2-(cyclohexylcarbonyl)-3-(4-methoxybenzylidene)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol for 3h; Claisen-Schmidt Condensation; Reflux; | 75% |
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
With Lawessons reagent In toluene for 3h; Heating; | 70% |
thiophene-2-carbaldehyde
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
2-(cyclohexylcarbonyl)-3-(thiophen-2-methylene)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol for 3h; Claisen-Schmidt Condensation; Reflux; | 70% |
4-methylpiperidin
formaldehyd
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
2-(cyclohexylcarbonyl)-3-((4-methylpiperidin-1-yl)methyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
Stage #1: 4-methylpiperidin; formaldehyd In ethanol for 0.5h; Mannich Aminomethylation; Reflux; Stage #2: 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one In ethanol for 8h; Reflux; | 65% |
1-methyl-piperazine
formaldehyd
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
2-2-(cyclohexylcarbonyl)-3-((4-methylpiperazin-1-yl)methyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
Stage #1: 1-methyl-piperazine; formaldehyd In ethanol for 0.5h; Mannich Aminomethylation; Reflux; Stage #2: 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one In ethanol for 8h; Reflux; | 60% |
formaldehyd
di-n-propylamine
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
2-(cyclohexylcarbonyl)-3-dipropylaminomethyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
Stage #1: formaldehyd; di-n-propylamine In ethanol for 0.5h; Mannich Aminomethylation; Reflux; Stage #2: 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one In ethanol for 8h; Reflux; | 60% |
formaldehyd
ethanolamine
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
2-2-(cyclohexylcarbonyl)-3-((2-hydroxyethylamino)methyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
Stage #1: formaldehyd; ethanolamine In ethanol for 0.5h; Mannich Aminomethylation; Reflux; Stage #2: 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one In ethanol for 8h; Reflux; | 60% |
benzaldehyde
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
2-(cyclohexylcarbonyl)-3-benzylidene-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol for 3h; Claisen-Schmidt Condensation; Reflux; | 60% |
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one
Conditions | Yield |
---|---|
With Lawessons reagent In toluene for 3h; Heating; | 50% |
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