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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

(1R,2R)-1,2-Cyclohexanedimethanol

Cas:65376-05-8

Min.Order:1 Kilogram

FOB Price: $80.0 / 100.0

Type:Lab/Research institutions

inquiry

Hangzhou Think Chemical Co. Ltd

Lurasidone Intermediates as follows: (3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione[CAS:14805-29-9] (1R,2R)-1,2-Cyclohexanedimethanol[CAS:65376-05-8] HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporatio

High quality (1R,2R)-1,2-Cyclohexanedimethanol supplier in China

Cas:65376-05-8

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

(1R,2R)-1,2-CYCLOHEXANEDIMETHANOL Intermediate of Lurasidone manufacturer

Cas:65376-05-8

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Manufacturer supply (1R,2R)-1,2-Cyclohexanedimethanol CAS 65376-05-8 with attractive price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its int

Manufacturer supply (1R,2R)-1,2-Cyclohexanedimethanol CAS 65376-05-8 with attractive price

Cas:65376-05-8

Min.Order:10 Gram

FOB Price: $10.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (1R,2R)-1,2-Cyclohexanedimethanol

Cas:65376-05-8

Min.Order:1

Negotiable

Type:Other

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

(1R,2R)-1,2-Cyclohexanedimethanol

Cas:65376-05-8

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

inquiry

Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less tha

(1R,2R)-1,2-Cyclohexanedimethanol

Cas:65376-05-8

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s

(1R,2R)-1,2-Cyclohexanedimethanol Manufacturer/High quality/Best price/In stock

Cas:65376-05-8

Min.Order:1 Kilogram

FOB Price: $7.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(1R,2R)-1,2-CYCLOHEXANEDIMETHANOL

Cas:65376-05-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/841.html Product Name (1R,2R)-1,2-Bis(hydroxymethyl)cyclohexane CAS No.

(1R,2R)-1,2-Cyclohexanedimethanol

Cas:65376-05-8

Min.Order:1 Gram

FOB Price: $65.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

(1R,2R)-1,2-CYCLOHEXANEDIMETHANOL

Cas:65376-05-8

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU-CHEM 65376-05-8 (1R,2R)-1,2-CYCLOHEXANEDIMETHANOL

Cas:65376-05-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

(1R, 2R) -1, 2-Bis (hydroxymethyl) Cyclohexane :65376-05-8

Cas:65376-05-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Lurasidone intermediate/(1R,2R)-1,2-Cyclohexanedimethanol CAS 65376-05-8

Cas:65376-05-8

Min.Order:25 Kilogram

FOB Price: $100.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 65376-05-8 with best quality

Cas:65376-05-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product (1R,2R)-1,2-Cyclohexanedimethanol Cas NO 65376-05-8 Product Information: Systematic Name: (1R,2R)-cyclohexane-1,2-diyldimethanol CAS NO: 65376-05-8 Molecular Formula: C8H16O2 Molecular Weight: 144.21 Purity: 99%

(1R,2R)-1,2-Cyclohexanedimethanol

Cas:65376-05-8

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

99% (1R,2R)-1,2-CYCLOHEXANEDIMETHANOL CAS: 65376-05-8

Cas:65376-05-8

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

(1R,2R)-1,2-Cyclohexanedimethanol 65376-05-8

Cas:65376-05-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

(1R,2R)-1,2-CYCLOHEXANEDIMETHANOL 99%

Cas:65376-05-8

Min.Order:1 Kilogram

FOB Price: $68.0 / 75.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

(1R,2R)-1,2-CYCLOHEXANEDIMETHANOL CAS: 65376-05-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qualit

(1R,2R)-1,2-CYCLOHEXANEDIMETHANOL CAS: 65376-05-8

Cas:65376-05-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(1R,2R)-1,2-Cyclohexanedimethanol

Cas:65376-05-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

(1R,2R)-Cyclohexane-1,2-diyldimethanol cas:65376-05-8

Cas:65376-05-8

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

(1R,2R)-1,2-Cyclohexanedimethanol

Cas:65376-05-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

(1R,2R)-1,2-Cyclohexanedimethanol

Cas:65376-05-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Product name: sodium metabisulfite / sodium metabisulphite Molecular weight: 190.10 Specification: 25Kg woven bag Quality guarantee period: 6 months Appearance:white powder Storage:Room Temperature Package:Carton(The aluminum foil

(1R,2R)-1,2-Cyclohexanedimethano

Cas:65376-05-8

Min.Order:10 Gram

FOB Price: $1.0 / 10.0

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(1R,2R)-Cyclohexane-1,2-diyldimethanol

Cas:65376-05-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(1R,2R)-1,2-Cyclohexanedimethanol

Cas:65376-05-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Jingye Medicine & Chemical Co., Ltd

98%Suzhou Jingye Medicine & Chemical Co., Ltd (Former: Suzhou Daxin Chemical Agent Factory) is a Hi-tech private enterprise, which is a professional manufacturer of hydrogenous products. It is located in Suzhou New District Chemical Area, about

(1R,2R)-1,2-Cyclohexanedimethanol

Cas:65376-05-8

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

(1R,2R)-1,2-CYCLOHEXANEDIMETHANOL

Cas:65376-05-8

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Synthetic route

(1R,2R)-1,2-cyclohexanedicarboxylic acid dimethyl ester
140459-96-7

(1R,2R)-1,2-cyclohexanedicarboxylic acid dimethyl ester

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

Conditions
ConditionsYield
With hydrogen In methanol at 190℃; under 52505.3 Torr; Temperature; Pressure; Solvent;94%
Stage #1: (1R,2R)-1,2-cyclohexanedicarboxylic acid dimethyl ester With diisobutylaluminium hydride In toluene at -5 - 20℃; for 6h; Inert atmosphere;
Stage #2: With hydrogenchloride; water In toluene at -5 - 40℃; for 13h;
74%
With lithium aluminium tetrahydride In diethyl ether
Stage #1: (1R,2R)-1,2-cyclohexanedicarboxylic acid dimethyl ester With diisobutylaluminium hydride In toluene at 0 - 20℃; for 4h; Inert atmosphere;
Stage #2: With hydrogenchloride In water at 0 - 40℃; for 18h;
With methanol; sodium tetrahydroborate In tetrahydrofuran at 40℃; for 3h; Temperature; Reflux;
(1R,2R)-(-)-trans-cyclohexane-1,2-dicarboxylic acid
46022-05-3

(1R,2R)-(-)-trans-cyclohexane-1,2-dicarboxylic acid

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

Conditions
ConditionsYield
With sodium tetrahydroborate; iodine In tetrahydrofuran at 0℃; for 5h; Reflux;88.4%
With Red-Al In tetrahydrofuran; toluene for 5h; Inert atmosphere; Reflux;85.2%
Multi-step reaction with 2 steps
1: diethyl ether
2: LiAlH4 / diethyl ether
View Scheme
(-)-(1R,2R)-trans-2-(hydroxymethyl)cyclohexanoic acid
65376-04-7

(-)-(1R,2R)-trans-2-(hydroxymethyl)cyclohexanoic acid

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether for 12h; Heating;80%
With lithium aluminium tetrahydride
bis(D-menthyl) (1R,2R)-cyclohexane-1,2-dicarboxylate

bis(D-menthyl) (1R,2R)-cyclohexane-1,2-dicarboxylate

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether at 0 - 20℃; for 19h; Inert atmosphere;76%
(+/-)-trans-2-(hydroxymethyl)cyclohexylmethanol
76155-27-6

(+/-)-trans-2-(hydroxymethyl)cyclohexylmethanol

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

Conditions
ConditionsYield
With C11H19NO
(+/-)-trans-2-(hydroxymethyl)cyclohexylmethanol
76155-27-6

(+/-)-trans-2-(hydroxymethyl)cyclohexylmethanol

A

trans-2-(hydroxymethyl)cyclohexanecarboxylic acid
57280-65-6, 65376-04-7, 80795-84-2, 93379-40-9

trans-2-(hydroxymethyl)cyclohexanecarboxylic acid

B

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

C

(1S,2S)-(–)-1,2-di(hydroxymethyl)cyclohexane
3205-34-3

(1S,2S)-(–)-1,2-di(hydroxymethyl)cyclohexane

D

(-)-(1R,2R)-trans-2-(hydroxymethyl)cyclohexanoic acid
65376-04-7

(-)-(1R,2R)-trans-2-(hydroxymethyl)cyclohexanoic acid

Conditions
ConditionsYield
With sodium hydroxide; NAD; silver nitrate; glycine; Flavin mononucleotide Product distribution; multistep reaction, other trans-diols, stereospecificity;
diethyl trans-1,2,3,6-tetrahydrophthalate
96946-89-3

diethyl trans-1,2,3,6-tetrahydrophthalate

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

Conditions
ConditionsYield
Stage #1: diethyl trans-1,2,3,6-tetrahydrophthalate With hydrogen; palladium on activated charcoal
Stage #2: With lithium aluminium tetrahydride
(3aR,7aS)-1,3,3a,4,7,7a-hexahydroisobenzofuran-1-one
65376-03-6

(3aR,7aS)-1,3,3a,4,7,7a-hexahydroisobenzofuran-1-one

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 86 percent / H2 / Pd/C / methanol
2: 34 percent / NaOH / H2O / 192 h / 130 °C
3: 80 percent / LiAlH4 / diethyl ether / 12 h / Heating
View Scheme
cis-1,2-cyclohexanedimethanol
15753-50-1

cis-1,2-cyclohexanedimethanol

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 80 percent / NAD+, FMN, pH 9, HLADH, NaOH, glycine / Ambient temperature
2: 34 percent / NaOH / H2O / 192 h / 130 °C
3: 80 percent / LiAlH4 / diethyl ether / 12 h / Heating
View Scheme
cis-1,6-dihydroxymethyl-3-cyclohexene
439919-46-7

cis-1,6-dihydroxymethyl-3-cyclohexene

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 83 percent / NAD+, FMN, pH 9, HLADH, NaOH, glycine / 48 h / 20 °C
2: 86 percent / H2 / Pd/C / methanol
3: 34 percent / NaOH / H2O / 192 h / 130 °C
4: 80 percent / LiAlH4 / diethyl ether / 12 h / Heating
View Scheme
(3aR,7aS)-hexahydroisobenzofuran-1-one
89395-29-9

(3aR,7aS)-hexahydroisobenzofuran-1-one

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 34 percent / NaOH / H2O / 192 h / 130 °C
2: 80 percent / LiAlH4 / diethyl ether / 12 h / Heating
View Scheme
1,2-cis-cyclohexanedicarboxylic anhydride
13149-00-3

1,2-cis-cyclohexanedicarboxylic anhydride

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: LiAlH4
2: 80 percent / NAD+, FMN, pH 9, HLADH, NaOH, glycine / Ambient temperature
3: 34 percent / NaOH / H2O / 192 h / 130 °C
4: 80 percent / LiAlH4 / diethyl ether / 12 h / Heating
View Scheme
phthalic acid dimethyl ester
131-11-3

phthalic acid dimethyl ester

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Raney nickel; methanol / 50 - 60 °C / 73550.8 Torr / Hydrogenation.Behandeln des Reaktionsprodukts mit methanol. Natriummethylat
2: LiAlH4; diethyl ether
3: (1R)-menthyl isocyanate
View Scheme
dimethyl cyclohexane-trans-1,2-dicarboxylate
3205-35-4

dimethyl cyclohexane-trans-1,2-dicarboxylate

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LiAlH4; diethyl ether
2: (1R)-menthyl isocyanate
View Scheme
(x)C8H11N*C8H12O4

(x)C8H11N*C8H12O4

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogenchloride / water
2.1: sulfuric acid / 18 h / 40 °C
3.1: diisobutylaluminium hydride / toluene / 6 h / -5 - 20 °C / Inert atmosphere
3.2: 13 h / -5 - 40 °C
View Scheme
trans-1,2-cyclohexanedicarboxylic acid
2305-32-0

trans-1,2-cyclohexanedicarboxylic acid

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: ethanol / 6.5 h / -70 - 20 °C / Resolution of racemate
2.1: hydrogenchloride / water
3.1: sulfuric acid / 18 h / 40 °C
4.1: diisobutylaluminium hydride / toluene / 6 h / -5 - 20 °C / Inert atmosphere
4.2: 13 h / -5 - 40 °C
View Scheme
Multi-step reaction with 2 steps
1.1: ethanol / 30 h / 35 - 75 °C
1.2: 1 h
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 65 °C
View Scheme
Multi-step reaction with 2 steps
1.1: (R)-1-phenyl-ethyl-amine / methanol; isopropyl alcohol / 30 - 40 °C
2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 25 - 30 °C
2.2: 1 h
View Scheme
Multi-step reaction with 4 steps
1: (R)-1-phenyl-ethyl-amine / methanol; isopropyl alcohol / 30 - 40 °C
2: tetrahydrofuran / 1 h / 25 - 30 °C
3: tetrahydrofuran / 45 - 50 °C
4: sodium tetrahydroborate; water / tetrahydrofuran / 1 h
View Scheme
(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: palladium; hydrogen / methanol / 30 - 35 °C
2.1: ethanol / 30 h / 35 - 75 °C
2.2: 1 h
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 65 °C
View Scheme
racemic trans-cyclohexane-1,2-dicarboxylic acid

racemic trans-cyclohexane-1,2-dicarboxylic acid

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: methanol / 0 - 35 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: Red-Al / tetrahydrofuran; toluene / 5 h / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 3 steps
1: (R)-1-phenyl-ethyl-amine / 5 °C
2: sulfuric acid / 4 h / Reflux
3: sodium tetrahydroborate; methanol / tetrahydrofuran / 3 h / 40 °C / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: diisopropylamine / ethanol / 3 h / -72 - 20 °C
2.1: sulfuric acid / 20 h / 10 - 50 °C
3.1: diisobutylaluminium hydride / toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.2: 18 h / 0 - 40 °C
View Scheme
(R,R)-1,2-cyclohexane dicarboxylic acid (R)-1-phenylethyl amine salt

(R,R)-1,2-cyclohexane dicarboxylic acid (R)-1-phenylethyl amine salt

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sulfuric acid / 20 h / 10 - 50 °C
2.1: diisobutylaluminium hydride / toluene / 4 h / 0 - 20 °C / Inert atmosphere
2.2: 18 h / 0 - 40 °C
View Scheme
dimethyl cis-1,2-cyclohexanedicarboxylate
1687-29-2

dimethyl cis-1,2-cyclohexanedicarboxylate

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium methylate / methanol / 4 h / Inert atmosphere; Reflux
1.2: 4 h / 75 °C / Inert atmosphere
1.3: 0 - 5 °C / pH 2 / Inert atmosphere
2.1: Red-Al / tetrahydrofuran; toluene / 5 h / Inert atmosphere; Reflux
View Scheme
C16H16N4O6

C16H16N4O6

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrahydrofuran / 45 - 50 °C
2: sodium tetrahydroborate; water / tetrahydrofuran / 1 h
View Scheme
((R,R)-cyclohexane-1,2-diyl)bis((1H-imidazol-1-yl)methanone)

((R,R)-cyclohexane-1,2-diyl)bis((1H-imidazol-1-yl)methanone)

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

Conditions
ConditionsYield
With sodium tetrahydroborate; water In tetrahydrofuran for 1h;15.5 g
(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

((1R,2R)-2-(((tert-butyldimethylsilyl)oxy)methyl)cyclohexyl)methanol
146611-58-7

((1R,2R)-2-(((tert-butyldimethylsilyl)oxy)methyl)cyclohexyl)methanol

Conditions
ConditionsYield
Stage #1: (+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane With n-butyllithium In tetrahydrofuran; cyclohexane at 0 - 20℃; for 3.25h; Inert atmosphere;
Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran; cyclohexane at 20℃; for 1h; Inert atmosphere;
99%
(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

8-oxabicyclo[4,3,0]nonane-7-one
2611-01-0

8-oxabicyclo[4,3,0]nonane-7-one

Conditions
ConditionsYield
With (CH3)5C5*Ir(-OCH2C(C6H5)2NH-) In acetone at 20℃; for 36h;98%
(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

p-methoxybenzyl chloride
824-94-2

p-methoxybenzyl chloride

A

((1R,2R)-2-{[(4-methoxybenzyl)oxy]methyl}cyclohexyl)methanol

((1R,2R)-2-{[(4-methoxybenzyl)oxy]methyl}cyclohexyl)methanol

B

C24H32O4

C24H32O4

Conditions
ConditionsYield
Stage #1: (+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane With sodium hydride In N,N-dimethyl-formamide; mineral oil at -20℃; for 0.5h; Inert atmosphere;
Stage #2: p-methoxybenzyl chloride In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h; Inert atmosphere;
A 97%
B 2%
(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

(1R,2R)-2-{[(4-methoxybenzyl)oxy]methyl}cyclohexanecarbaldehyde

(1R,2R)-2-{[(4-methoxybenzyl)oxy]methyl}cyclohexanecarbaldehyde

Conditions
ConditionsYield
Stage #1: (+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane With oxalyl dichloride; dimethyl sulfoxide In dichloromethane at -60℃; Inert atmosphere;
Stage #2: With triethylamine In dichloromethane at -50 - 20℃; Inert atmosphere;
94%
(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

(1R,2R)-(-)-trans-cyclohexane-1,2-diylbis(methylene)dimethanesulfonate
186204-35-3

(1R,2R)-(-)-trans-cyclohexane-1,2-diylbis(methylene)dimethanesulfonate

Conditions
ConditionsYield
With triethylamine at 0 - 5℃; Industrial scale;92.6%
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;92%
With triethylamine In chloroform at 0 - 20℃; for 5h;90.8%
(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

(R)-trans-1,2-bis-(toluene-4-sulfonyloxymethyl)-cyclohexane
3205-36-5, 7436-01-3, 59461-66-4, 62208-94-0, 76155-28-7, 95810-29-0

(R)-trans-1,2-bis-(toluene-4-sulfonyloxymethyl)-cyclohexane

Conditions
ConditionsYield
With triethylamine In dichloromethane at -10 - 0℃; for 3h; Concentration;92.5%
(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

C18H17N3O2S

C18H17N3O2S

C32H38N6O4S2

C32H38N6O4S2

Conditions
ConditionsYield
Stage #1: (+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane With sodium hydroxide In tetrahydrofuran
Stage #2: C18H17N3O2S In tetrahydrofuran at 70℃; for 2h; Reagent/catalyst; Solvent; Temperature;
74%
(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

C18H17N3O2S

C18H17N3O2S

C20H27N3O3S

C20H27N3O3S

Conditions
ConditionsYield
Stage #1: (+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane With sodium hydroxide In tetrahydrofuran
Stage #2: C18H17N3O2S In tetrahydrofuran at -10℃;
32%
(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

trans-8-oxabicyclo[4.3.0]nonan-7-ol

trans-8-oxabicyclo[4.3.0]nonan-7-ol

Conditions
ConditionsYield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In water; dimethyl sulfoxide at 23℃; for 2h;
(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

ethyl (+/-)-(2E)-3-[(1RS,2SR)-2-(hydroxymethyl)-cyclohexyl]-2-propenoate

ethyl (+/-)-(2E)-3-[(1RS,2SR)-2-(hydroxymethyl)-cyclohexyl]-2-propenoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: o-iodoxybenzoic acid / dimethylsulfoxide; H2O / 2 h / 23 °C
2: benzene / 16 h / Heating
View Scheme
(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

ethyl (+/-)-(2E)-3-[(1RS,2SR)-2-(iodomethyl)cyclohexyl]-2-propenoate

ethyl (+/-)-(2E)-3-[(1RS,2SR)-2-(iodomethyl)cyclohexyl]-2-propenoate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: o-iodoxybenzoic acid / dimethylsulfoxide; H2O / 2 h / 23 °C
2: benzene / 16 h / Heating
3: 94 percent / triethylamine / CH2Cl2 / 0 °C
4: 84 percent / sodium iodide / acetone / 14 h / Heating
View Scheme
(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

ethyl (+/-)-(2E)-3-{(1RS,2SR)-2-[(methanesulfonyloxy)methyl]cyclohexane}-2-propenoate

ethyl (+/-)-(2E)-3-{(1RS,2SR)-2-[(methanesulfonyloxy)methyl]cyclohexane}-2-propenoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: o-iodoxybenzoic acid / dimethylsulfoxide; H2O / 2 h / 23 °C
2: benzene / 16 h / Heating
3: 94 percent / triethylamine / CH2Cl2 / 0 °C
View Scheme
(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

(+/-)-(1RS,3aSR,7aSR)-1,3,3a,4,5,6,7,7a-octahydrobenzo[c]thiophene-1-acetic acid

(+/-)-(1RS,3aSR,7aSR)-1,3,3a,4,5,6,7,7a-octahydrobenzo[c]thiophene-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: o-iodoxybenzoic acid / dimethylsulfoxide; H2O / 2 h / 23 °C
2: benzene / 16 h / Heating
3: 94 percent / triethylamine / CH2Cl2 / 0 °C
4: 84 percent / sodium iodide / acetone / 14 h / Heating
5: 97 percent / ethanol / 120 h / Heating
6: 75 percent / potassium hydroxide; water / 8 h / Heating
View Scheme
(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

(+/-)-(1SR,3aSR,7aSR)-1,3,3a,4,5,6,7,7a-octahydrobenzo[c]thiophene-1-acetic acid

(+/-)-(1SR,3aSR,7aSR)-1,3,3a,4,5,6,7,7a-octahydrobenzo[c]thiophene-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: o-iodoxybenzoic acid / dimethylsulfoxide; H2O / 2 h / 23 °C
2: benzene / 16 h / Heating
3: 94 percent / triethylamine / CH2Cl2 / 0 °C
4: 84 percent / sodium iodide / acetone / 14 h / Heating
5: 97 percent / ethanol / 120 h / Heating
6: 10 percent Chromat. / potassium hydroxide; water / 8 h / Heating
View Scheme
(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

ethyl (+/-)-(1RS,3aSR,7aSR)-2-benzyl-2,3,3a,4,5,6,7,7a-octahydro-1H-isoindole-1-acetate

ethyl (+/-)-(1RS,3aSR,7aSR)-2-benzyl-2,3,3a,4,5,6,7,7a-octahydro-1H-isoindole-1-acetate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: o-iodoxybenzoic acid / dimethylsulfoxide; H2O / 2 h / 23 °C
2: benzene / 16 h / Heating
3: 94 percent / triethylamine / CH2Cl2 / 0 °C
4: 84 percent / sodium iodide / acetone / 14 h / Heating
5: 70 percent / triethylamine / 120 h / Heating
View Scheme
(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

(E)-3-((1R,2S)-2-Carbamimidoylsulfanylmethyl-cyclohexyl)-acrylic acid ethyl ester; hydriodide

(E)-3-((1R,2S)-2-Carbamimidoylsulfanylmethyl-cyclohexyl)-acrylic acid ethyl ester; hydriodide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: o-iodoxybenzoic acid / dimethylsulfoxide; H2O / 2 h / 23 °C
2: benzene / 16 h / Heating
3: 94 percent / triethylamine / CH2Cl2 / 0 °C
4: 84 percent / sodium iodide / acetone / 14 h / Heating
5: 97 percent / ethanol / 120 h / Heating
View Scheme
(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane
65376-05-8

(+)-(1R,2R)-trans-1,2-bis(hydroxymethyl)cyclohexane

(3aR)-trans-octahydro-isobenzofuran
4743-54-8, 10479-79-5, 13149-01-4

(3aR)-trans-octahydro-isobenzofuran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine
2: aqueous KOH-solution
View Scheme

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