Shandong Kehui Pharmaceutical Co., Ltd. is a modern high-tech pharmaceutical company that strictly complies with GMP requirements and produces high standards. The company was established in May 2017 and is located in the Yellow River Delta Medicine V
Product Name: Felodipine Synonyms: ,ethylmethylester;ethylmethyl4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedica;Felodipine, 98%, Selective L-type Ca2+ channel blocker;Clevidipine Butyrate Impurity 2;4-(2,3-Dichlorophenyl)-2,6-di
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Min.Order:100 Gram
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inquiryProduct name: Felodipine CAS No.: 72509-76-3 Quality standard: USP24 Assay: 99%min MF:C18H19Cl2NO4 Use:calcium antagonist Appearance: White Crystaline Powder Appearance:White powder Storage:Store in cool and dry place, away from sun light.
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Min.Order:10 Gram
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Min.Order:1 Gram
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Cas:72509-76-3
Min.Order:10 Gram
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Type:Trading Company
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inquiryFelodipine Basic information Product Name: Felodipine Synonyms: ,ethylmethylester;ethylmethyl4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedica;4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylic acid methyl
2-<(2,3-dichlorophenyl)methylene>-3-oxobutanoic acid ethyl ester
methyl 3-aminocrotonate
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Conditions | Yield |
---|---|
In ethanol for 0.075h; Irradiation; Teflon vessel, microwave oven; | 96% |
ethyl 3-aminobut-2-enoate
acetoacetic acid methyl ester
2,3-dichlorobenzylaldehyde
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Conditions | Yield |
---|---|
Stage #1: ethyl 3-aminobut-2-enoate; acetoacetic acid methyl ester; 2,3-dichlorobenzylaldehyde With piperidine; pyridine In neat (no solvent) at 75 - 80℃; for 9h; Stage #2: With ethanol for 1h; Reagent/catalyst; Solvent; Reflux; | 94.3% |
(Z)-methyl 2-(2,3-dichlorobenzylidene)-3-oxobutanoate
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Conditions | Yield |
---|---|
In isopropyl alcohol for 12h; Heating / reflux; | 86% |
C33H34Cl2N2O7S
sodium methylate
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Conditions | Yield |
---|---|
In methanol chemoselective reaction; | 84% |
2-<(2,3-dichlorophenyl)methylene>-3-oxobutanoic acid ethyl ester
1,1,1-Triphenyl-3-methyl-4-(methoxycarbonyl)-2-aza-1λ5-phosphabuta-1,3-diene
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Conditions | Yield |
---|---|
In dichloromethane at 40℃; for 24h; | 82% |
methyl iodide
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 25℃; for 24h; | 70% |
acetoacetic acid methyl ester
2,3-dichlorobenzylaldehyde
A
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
B
4-(-2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl ester
C
4-(2,3-dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester
Conditions | Yield |
---|---|
Stage #1: acetoacetic acid methyl ester; 2,3-dichlorobenzylaldehyde; piperidine; 2-Picolinic acid In isopropyl alcohol at 40 - 45℃; for 6h; Stage #2: ethyl aminocrotonate In isopropyl alcohol for 4h; Heating / reflux; | A 66% B n/a C n/a |
ethyl 3-aminobut-2-enoate
2,3-dichlorobenzylaldehyde
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Conditions | Yield |
---|---|
In hexane; isopropyl alcohol | 62% |
ethyl 2-(2,3-dichlorobenzylidene)-3-oxobutanoate
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 71 percent / 2-methyl-propan-2-ol / 96 h / 25 °C 2: 72.7 percent / DBU / methanol / 48 h / 25 °C 3: 70 percent / K2CO3 / dimethylformamide / 24 h / 25 °C View Scheme |
4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-cyano-ethyl) ester 5-ethyl ester
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 72.7 percent / DBU / methanol / 48 h / 25 °C 2: 70 percent / K2CO3 / dimethylformamide / 24 h / 25 °C View Scheme |
C32H33Cl2NO7S
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: pyridine / 4 h / Reflux 2: toluene-4-sulfonic acid / ethanol; water / 2 h / 20 °C / Inert atmosphere 3: methanol View Scheme |
C38H42Cl2N2O8S
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: toluene-4-sulfonic acid / ethanol; water / 2 h / 20 °C / Inert atmosphere 2: methanol View Scheme |
ethyl 3-aminobut-2-enoate
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: pyridine / 4 h / Reflux 2: toluene-4-sulfonic acid / ethanol; water / 2 h / 20 °C / Inert atmosphere 3: methanol View Scheme |
ethylene glycol
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
1-ethenyl-2-pyrrolidinone
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
ethyl aminocrotonate
(Z)-methyl 2-(2,3-dichlorobenzylidene)-3-oxobutanoate
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Conditions | Yield |
---|---|
at 25 - 30℃; for 11h; Product distribution / selectivity; |
ethyl acetoacetate
acetoacetic acid methyl ester
2,3-dichlorobenzylaldehyde
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Conditions | Yield |
---|---|
With ammonium acetate In ethanol at 80℃; for 2h; Hantzsch Pyridine Synthesis; |
(E/Z)-methyl 2-(2,3-dichlorobenzylidene)acetoacetate
ethyl aminocrotonate
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Conditions | Yield |
---|---|
at 90℃; for 0.15h; Microwave irradiation; |
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Dehydrofelodipine
Conditions | Yield |
---|---|
With potassium carbonate; eosin Y bis(tetrabutyl ammonium salt) In methanol; water at 20℃; for 12h; Irradiation; Green chemistry; | 83% |
With potassium carbonate In ethanol; water at 20℃; for 12h; | 83.1% |
Stage #1: ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate With hydrogenchloride In water Stage #2: With nickel In water at 20℃; for 4h; | 72.4% |
With potassium phosphate; ethylenediaminetetraacetic acid; Emulgen 911; human liver cytochrome b5; human liver HL 39 lipid extract; rabbit liver NADPH-P-450 reductase; yeast P-450 IIIA4; magnesium chloride In water Rate constant; other human liver enzymes; |
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
A
(R)-Felodipine
B
(S)-Felodipine
Conditions | Yield |
---|---|
With α1-acid glycoprotein HPLC column resolution of racemate; | |
With Chiralpak IC In ethanol; hexane; isopropyl alcohol Reagent/catalyst; Solvent; Resolution of racemate; |
1,4-diaza-bicyclo[2.2.2]octane
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Conditions | Yield |
---|---|
In ethanol at 20℃; |
N,N-dimethyl acetamide
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Conditions | Yield |
---|---|
at 50℃; |
1,3-dimethyl-2-imidazolidinone
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Conditions | Yield |
---|---|
at 50℃; |
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
tetramethylurea
Conditions | Yield |
---|---|
at 50℃; |
4,4'-bipyridine
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Conditions | Yield |
---|---|
In acetone at 20℃; Solvent; |
4,4'-bipyridine
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Conditions | Yield |
---|---|
In acetone at 20℃; |
1H-imidazole
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate
Conditions | Yield |
---|---|
In methanol for 0.5h; |
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