Camptothecin Extract Main Contents: Camptothecin Plant Resource: Camptotheca acuminata CAS#: 7689-03-4 Main Specification: 92%, 95%,98%, 99% HPLC Appearance: Light Yellow Needle-like crystal Molecular Weight: C20H16N2O4 Molecul
Cas:7689-03-4
Min.Order:1 Kilogram
FOB Price: $3985.0
Type:Trading Company
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:7689-03-4
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryItems Standard Result Appearance Yellowish crystals powder Conforms Assay(HPLC) 99%min
Cas:7689-03-4
Min.Order:1 Kilogram
FOB Price: $3950.0 / 4450.0
Type:Manufacturers
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:7689-03-4
Min.Order:1 Metric Ton
Negotiable
Type:Manufacturers
inquiryQuickDetails Type:HerbalExtract,pharmaceuticalingredients Variety:10-Hydroxycamptothecin Form:Powder …Appearance:yellow solid Storage:Preserve in tightly sealed,light and oxygen resistant containers Pa
hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:7689-03-4
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Manufacturers
inquiryUnique advantages for Camptothecin Cas 7689-03-4 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Pale yellow crystal powder Storage:Store at 2-8°C Package:100g,1kg/foil b
Cas:7689-03-4
Min.Order:100 Gram
Negotiable
Type:Trading Company
inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:7689-03-4
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:7689-03-4
Min.Order:1
Negotiable
Type:Other
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:7689-03-4
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:7689-03-4
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryTIANFUCHEM-- 7689-03-4--High purity (+)-Camptothecin in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business
Cas:7689-03-4
Min.Order:1 Metric Ton
FOB Price: $2000.0
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:7689-03-4
Min.Order:1 Kilogram
FOB Price: $1.0 / 20.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:7689-03-4
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryProduct Name: (+)-Camptothecin CAS: 7689-03-4 MF: C20H16N2O4 MW: 348.35 EINECS: 444-280-6 Appearance: Light yellow crystalline powder Appearance:Light yellow crystalline powder Storage:Store in cool and dry place, away from sun light. Package:25
Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
Cas:7689-03-4
Min.Order:10 Gram
Negotiable
Type:Other
inquiry10-Hydroxy camptothecin in bulk supply Favorable price,high quality Bulk stock, prompt delivery Purity 99% Free sample Appearance:yellow solid Storage:dry and cool place Package:1kg/pack Application:Hydroxy camptothecin and its derivatives are u
Cas:7689-03-4
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryHanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d
We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:7689-03-4
Min.Order:10 Gram
FOB Price: $2.0
Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:7689-03-4
Min.Order:1 Gram
FOB Price: $20.0 / 25.0
Type:Trading Company
inquiry(+)-Camptothecin CAS: 7689-03-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermed
Cas:7689-03-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:7689-03-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAbout Product Details
Cas:7689-03-4
Min.Order:500 Kilogram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
(+)-Camptothecin CAS: 7689-03-4 Specification Appearance & Physical State light yellow crystal powde Density 1.51 g/cm3 Boiling Point 264ºC Melting Point 260ºC Flash Point 41
1.strict raw material selection 2.mature production process 3.perfect quality control system 4.intimate servcie 5.competitive price 6.downstream customization 7.has a number of highly qualified engineers and experts to provide guida
Cas:7689-03-4
Min.Order:100 Gram
Negotiable
Type:Trading Company
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Specification : 1,6-DIHYDROXY-7-GLUCURONOSYLFLAVO
Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h
Cas:7689-03-4
Min.Order:100 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:7689-03-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryC29H39N3O3Si2
camptothecin
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether; ethanol Pinner reaction; Heating; | 92% |
camptothecin 20-(2-bromo)-n-butyrate
camptothecin
Conditions | Yield |
---|---|
With methanol; ammonia In tetrahydrofuran for 12h; Product distribution / selectivity; | 89% |
(E)-N-(2-aminobenzylidene)-4-methylaniline
(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
camptothecin
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene Heating; 1) 30 min, 2) 3 h; | 84.4% |
With toluene-4-sulfonic acid In toluene Heating; 1.) 30 min, 2.) 3 h with Dean-Stark trap; | 84% |
With toluene-4-sulfonic acid In toluene | 73% |
With toluene-4-sulfonic acid 1.) toluene, reflux, 30 min, 2.) toluene, reflux, 3 h; Yield given. Multistep reaction; |
4-ethyl-1,12-dihydro-14H-pyrano[3',4':6,7indolizino[1,2-b]]quinolin-14-one
camptothecin
Conditions | Yield |
---|---|
Stage #1: 4-ethyl-1,12-dihydro-14H-pyrano[3',4':6,7indolizino[1,2-b]]quinolin-14-one With potassium osmate; hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; methanesulfonamide; potassium carbonate; potassium hexacyanoferrate(III) In water; tert-butyl alcohol at 0℃; Stage #2: With iodine; calcium carbonate In methanol; water at 40℃; | 83% |
Multi-step reaction with 2 steps 1: K2CO3; MeSO2NH2; K3Fe(CN)6 / OsO4; (DHQD)2-Py / 2-methyl-propan-2-ol; H2O / 7 h / 0 °C 2: I2; CaCO3 / methanol; H2O / 24 h / 20 °C View Scheme | |
With methanol; iodine; calcium carbonate In water Sharpless Dihydroxylation; | |
Multi-step reaction with 2 steps 1: potassium carbonate; hydroquinidine (2,5-diphenyl-4,6-pyrimidinediyl) diether; potassium hexacyanoferrate(III); potassium osmate(VI) dihydrate; methanesulfonamide / water; tert-butyl alcohol / 72 h / 0 °C / Inert atmosphere 2: iodine; calcium carbonate / methanol; water / 20 h / 40 °C / Inert atmosphere View Scheme |
(S)-O-methylcamptothecin
camptothecin
Conditions | Yield |
---|---|
With hydrogen bromide for 0.416667h; Heating; | 81% |
A
camptothecin-20-(N-succinamidoglycinate)
C
camptothecin-20-(N-succinimidoglycinate)
D
camptothecin
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water; N,N-dimethyl-formamide; acetonitrile at -2 - 20℃; for 3.5h; pH=5.9 - 6.0; | A n/a B 80% C n/a D n/a |
Conditions | Yield |
---|---|
With hydrogenchloride; acetic acid In 1,4-dioxane; water at 90℃; for 19h; | 80% |
(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
2-aminobenzaldehyde
camptothecin
Conditions | Yield |
---|---|
With chloro-trimethyl-silane In N,N-dimethyl-formamide at 100℃; Friedlaender Quinoline Synthesis; | 78% |
With toluene-4-sulfonic acid In toluene for 2h; Heating; | 57% |
Conditions | Yield |
---|---|
With sulfuric acid In 1,4-dioxane for 0.5h; Irradiation; | A 75% B 11.5% |
1,2,6,7-tetrahydrocamptothecin
A
(S)-10-hydroxycamptothecin
B
camptothecin
Conditions | Yield |
---|---|
With lead(IV) acetate; trifluoroacetic acid for 0.25h; Ambient temperature; | A 73.5% B 12% |
phenyl isocyanate
(S)-4-ethyl-4-hydroxy-6-iodo-7-(prop-2-yn-1-yl)-1,7-dihydro-3H-pyrano[3,4-c]pyridino-3,8(4H)-dione
camptothecin
Conditions | Yield |
---|---|
With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; potassium carbonate; triethylamine In acetonitrile at 20℃; for 24h; Inert atmosphere; Schlenk technique; Irradiation; | 73% |
With hexamethyldistannane In benzene at 70℃; for 5h; Irradiation; | 63% |
With hexamethyldistannane In benzene | 21.8 mg (63%) |
camptothecin 20-(4-bromo)-n-butyrate
camptothecin
Conditions | Yield |
---|---|
With methanol; ammonia In tetrahydrofuran for 12h; Product distribution / selectivity; | 72% |
4-ethyl-1,12-dihydro-14H-pyrano[3',4':6,7indolizino[1,2-b]]quinolin-14-one
A
(R)-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H)-dione
B
camptothecin
Conditions | Yield |
---|---|
Stage #1: 4-ethyl-1,12-dihydro-14H-pyrano[3',4':6,7indolizino[1,2-b]]quinolin-14-one With methanesulfonamide; potassium carbonate; potassium hexacyanoferrate(III); hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; potassium dioxotetrahydroxoosmate(VI) In water; tert-butyl alcohol at 0℃; for 40h; Sharpless dihydroxylation; Stage #2: With iodine; calcium carbonate In methanol; water at 40℃; for 15h; Further stages.; | A n/a B 71% |
N-(2-(1,3-dioxolan-2-yl))phenylamine
(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
camptothecin
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene for 3h; Heating; | 69% |
N-(2-(1,3-dioxolan-2-yl))phenylamine
4'-ethyl-1',4',7',8'-tetrahydro-4'-hydroxy-3'H,10'H-spiro[1,3-dioxolane-2,6'-pyrano[3,4-f]indolizine]-3',10'-dione
camptothecin
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water for 4h; Friedlaender synthesis; Reflux; | 66% |
(S)-7-[(2-chloroquinolin-3-yl)methyl]-4-ethyl-4-hydroxy-1Hpyrano[3,4-c]pyridine-3,8(4H,7H)-dione
camptothecin
Conditions | Yield |
---|---|
With bis(triphenylphosphine) palladium (Il) acetate; potassium acetate In acetonitrile at 100℃; for 12h; Heck reaction; | 64% |
With bis(acetato)bis(triphenylphosphine)palladium(0); potassium acetate In acetonitrile at 100℃; for 12h; Heck reaction; Inert atmosphere; optical yield given as %ee; | 64% |
Conditions | Yield |
---|---|
With sulfuric acid; sodium nitrite In water for 1h; Heating; | A 60% B n/a |
(-)-O,21-dihydrocamptothecin
camptothecin
Conditions | Yield |
---|---|
With iodine; calcium carbonate In methanol; water at 20℃; for 96h; | 60% |
With iodine; calcium carbonate In methanol; water at 40℃; for 24h; Inert atmosphere; optical yield given as %ee; | |
With iodine; calcium carbonate In methanol; water at 40℃; for 20h; Inert atmosphere; | 59 mg |
tert-butyldimethylsilane
Camptothecin 1-oxide
A
camptothecin
B
(20S)-7-tert-butyldimethylsilylcamptothecin
Conditions | Yield |
---|---|
With di-tert-butyl peroxide; triisopropylsilanethiol | A 60% B 20% C n/a |
(S)-7-(2-Bromo-quinolin-3-ylmethyl)-4-ethyl-4-hydroxy-1,7-dihydro-4H-pyrano[3,4-c]pyridine-3,8-dione
camptothecin
Conditions | Yield |
---|---|
With palladium diacetate; tetrabutylammomium bromide; potassium acetate In N,N-dimethyl-formamide at 90℃; for 3h; | 59% |
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In toluene Heating; | 55% |
With palladium diacetate; potassium carbonate; triphenylphosphine In toluene for 16h; Heck reaction; Reflux; Inert atmosphere; |
camptothecin 20-(5-bromo)-n-pentanoate
camptothecin
Conditions | Yield |
---|---|
With methanol; ammonia In tetrahydrofuran for 120h; Product distribution / selectivity; | 59% |
4-ethyl-1,12-dihydro-14-H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H)-dione
camptothecin
Conditions | Yield |
---|---|
Stage #1: 4-ethyl-1,12-dihydro-14-H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H)-dione With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.5h; enolization; Stage #2: With (+)-(2S,8aS)-(camphorylsulfonyl)oxaziridine In tetrahydrofuran at -78℃; for 3h; Substitution; asymmetric hydroxylation; | 53% |
(S)-4-ethyl-4-hexanoyloxy-1,12-dihydro-4H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
camptothecin
Conditions | Yield |
---|---|
With methanol; ammonia In tetrahydrofuran for 120h; Product distribution / selectivity; | 42% |
acetic acid
1,2,6,7-tetrahydrocamptothecin
A
(S)-10-hydroxycamptothecin
B
(S)-9-acetoxy-4-ethyl-4-hydroxy-1,12-dihydro-4H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
C
camptothecin
Conditions | Yield |
---|---|
With lead(IV) acetate for 0.25h; Ambient temperature; | A 30.9% B 20.8% C 8.1% |
phenyl isocyanate
(S)-4-Ethyl-4-hydroxy-6-iodo-3-oxo-7-allyl-1H-pyrano[3,4-c]-8-pyridone
camptothecin
Conditions | Yield |
---|---|
With hexamethyldistannane In benzene Irradiation; | 21% |
camptothecin-21-isopropylamide
A
camptothecin
B
N-Isopropyl-17-hydroxycamptothecin Lactam
C
N-Isopropyl-17-oxocamptothecin Lactam
Conditions | Yield |
---|---|
With manganese(IV) oxide In dichloromethane for 72h; Ambient temperature; | A 3.4% B 8.1% C 12% |
camtothecin-20-O-methyl carbonate
camptothecin
Conditions | Yield |
---|---|
With lithium hydrogensulfide In N,N,N,N,N,N-hexamethylphosphoric triamide |
camptothecin
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In methanol for 0.333333h; Ambient temperature; | |
With hydrogen; palladium 10% on activated carbon In 1,4-dioxane; methanol at 20℃; for 1 - 5h; |
camptothecin
camptothecin
Conditions | Yield |
---|---|
With Britton-Robinson's buffer pH 6.0; water at 37℃; Equilibrium constant; Kinetics; Thermodynamic data; Ea, A, var. pH, var. temp., var. time; | |
With PBS buffer at 37℃; pH=7.4; Kinetics; |
benzyloxyacetic acid
camptothecin
Conditions | Yield |
---|---|
With dmap; diisopropyl-carbodiimide In dichloromethane at 20℃; for 12h; | 100% |
With dmap In dichloromethane for 12h; | 100% |
With dmap; diisopropyl-carbodiimide In dichloromethane at 20℃; for 12h; | 100% |
With dmap; bis-2-propyl carbonate In dichloromethane at 0℃; for 3h; | 65% |
N-(tert-butoxycarbonyl)-glycine N-carboxyanhydride
camptothecin
camptothecin N-tert-butyoxylcarboxylglycine ester
Conditions | Yield |
---|---|
With dmap In dichloromethane for 8h; Heating; | 100% |
camptothecin
20(S)-camptothecin sodium salt
Conditions | Yield |
---|---|
With sodium hydroxide; water at 50℃; for 1h; | 100% |
With sodium hydroxide; water at 50℃; for 2h; |
Conditions | Yield |
---|---|
sulfuric acid In ethanol at 80 - 120℃; for 14h; | 99% |
With pyridine at 40℃; for 48h; | 94% |
With pyridine at 35 - 45℃; for 48h; | 94% |
t-BuOCO-Gly-Sar-OH
camptothecin
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20 - 25℃; for 15h; | 99% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 15h; | 99% |
camptothecin
(-)-O,21-dihydrocamptothecin
Conditions | Yield |
---|---|
With potassium borohydride In methanol at 20℃; Inert atmosphere; | 99% |
With potassium borohydride In methanol at 20℃; for 1h; | 98.4% |
With sodium tetrahydroborate In methanol at 20℃; | 90% |
camptothecin
3-fluoro-4-cyanophenoxyacetic acid
camptothecin-20-O-4-cyano-3-fluorophenoxyacetate
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 20h; | 98.7% |
camptothecin
(R,S)-2-chloropropionic acid
camptothecin-20-O-2-chloropropionate
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2h; | 98.1% |
Conditions | Yield |
---|---|
With pyridine at 40℃; for 48h; | 98% |
With pyridine | 98% |
triethylsilyl chloride
camptothecin
20(S)-O-triethylsilylcamptothecin
Conditions | Yield |
---|---|
With 1H-imidazole; dmap In N,N-dimethyl-formamide at 20℃; for 60h; | 98% |
With 1H-imidazole; dmap In N,N-dimethyl-formamide at 20℃; Inert atmosphere; | 98% |
With 1H-imidazole; dmap In N,N-dimethyl-formamide for 46h; Inert atmosphere; | |
Stage #1: camptothecin With 1H-imidazole In N,N-dimethyl-formamide for 0.166667h; Inert atmosphere; Stage #2: triethylsilyl chloride With dmap In N,N-dimethyl-formamide | |
With 1H-imidazole; dmap In N,N-dimethyl-formamide for 46.1667h; |
succinic acid anhydride
camptothecin
(S)-4-((4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl)oxy)-4-oxobutanoic acid
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 0 - 20℃; for 4h; | 98% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 0 - 20℃; for 4h; Inert atmosphere; | 98% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane for 4h; Inert atmosphere; Cooling with ice; | 90% |
Conditions | Yield |
---|---|
With dmap; diisopropyl-carbodiimide In dichloromethane at 0 - 20℃; | 98% |
Conditions | Yield |
---|---|
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 20℃; for 12h; Inert atmosphere; | 98% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; Inert atmosphere; | 98% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 25℃; for 12h; | 55% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 12h; | 55% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 7h; | 97.5% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2h; | 97.5% |
Conditions | Yield |
---|---|
With dmap; 2-chloro-1-methyl-pyridinium iodide In N,N-dimethyl acetamide at 50℃; | 97.4% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2h; | 97% |
With dmap In dichloromethane for 5h; Cooling with ice; | 71% |
In dichloromethane for 5h; Cooling with ice; | 71% |
With dmap; bis-2-propyl carbonate In dichloromethane at 0℃; for 4h; | 67% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2h; |
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid
camptothecin
Boc-Inp-CPT
Conditions | Yield |
---|---|
Stage #1: N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 0.5h; Stage #2: camptothecin In dichloromethane at 20℃; for 18h; | 97% |
Conditions | Yield |
---|---|
With dmap; diisopropyl-carbodiimide In dichloromethane at 0 - 20℃; | 97% |
camptothecin
Camptothecin 1-oxide
Conditions | Yield |
---|---|
With sodium perborate; acetic acid at 30 - 90℃; for 0.833333h; | 96.46% |
With dihydrogen peroxide; acetic acid at 70 - 80℃; for 3.5h; | 90.6% |
With dihydrogen peroxide In acetic acid at 70 - 80℃; for 3.5h; | 90.6% |
Conditions | Yield |
---|---|
Stage #1: camptothecin With sulfuric acid; formamide; trifluoroacetic acid; iron(II) sulfate In water at 5℃; Stage #2: tert.-butylhydroperoxide In water at 0℃; for 1h; | 96.1% |
With sulfuric acid; iron(II) sulfate In water; acetic acid for 1h; Ambient temperature; | 79% |
camptothecin
8-methyl-7-propionylindolizino[1,2-b]quinoline-9(11H)-one
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate for 0.116667h; Ambient temperature; microwave irradiation; | 96% |
for 0.116667h; Irradiation; | 96% |
With sodium azide; 18-crown-6 ether In N,N-dimethyl-formamide at 110 - 120℃; for 18h; Mechanism; | 94% |
Boc-(R)-Ala
camptothecin
Conditions | Yield |
---|---|
With dmap; scandium tris(trifluoromethanesulfonate); diisopropyl-carbodiimide In dichloromethane at -8 - 20℃; for 2.5h; | 96% |
BOC-glycine
camptothecin
camptothecin N-tert-butyoxylcarboxylglycine ester
Conditions | Yield |
---|---|
With dmap; diisopropyl-carbodiimide In dichloromethane at 0 - 20℃; | 96% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2h; | 94.8% |
With dmap; diisopropyl-carbodiimide In dichloromethane at 0℃; for 1h; | 86.2% |
Conditions | Yield |
---|---|
With sulfuric acid; dihydrogen peroxide; acetic acid at -5 - 5℃; for 0.166667h; Temperature; | 95.4% |
With sulfuric acid; dihydrogen peroxide; iron(II) sulfate In water for 3h; Ambient temperature; | 77% |
With sulfuric acid; dihydrogen peroxide; iron(II) sulfate for 3h; Ambient temperature; | 77% |
camptothecin
3-[4-(4-fluorophenyl)-1-piperazinyl]propionic acid
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 7h; | 95.2% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane Ambient temperature; | 95% |
L-N-Boc-Ala
camptothecin
20-O-(N-(tert-butoxycarbonyl)alanyl)camptothecin
Conditions | Yield |
---|---|
With dmap; scandium tris(trifluoromethanesulfonate); diisopropyl-carbodiimide In dichloromethane at -8 - 20℃; for 2.5h; | 95% |
With dmap; diisopropyl-carbodiimide In dichloromethane at 0 - 20℃; | 94% |
With dmap; diisopropyl-carbodiimide In dichloromethane at 0℃; for 1h; | 86.2% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane Ambient temperature; | 95% |
1H-benzo[d][1,2,3]triazol-1-yl (2-(pyridin-2-yldisulfaneyl)ethyl) carbonate
camptothecin
camptothecin-(4-pyridyldisulfanyl)ethyl carbonate
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 20℃; | 95% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View