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AstaTech ( Chengdu) BioPharmaceutical Corp.

in stock Package:1kg,10kg Application:Pharmaceutical intermediates

BENZOFURAN-6-CARBOXYLIC ACID

Cas:77095-51-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

6-Benzofurancarboxylic acid Manufacturer/High quality/Best price/In stock

Cas:77095-51-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up by HPLC 6-Benzofurancarboxylic Acid 77095-51-3

Cas:77095-51-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

6-Benzofurancarboxylic acid CAS No.:77095-51-3 Name: 6-Benzofurancarboxylic acid Molecular Structure Molecular Formula: C9H6O3

High purity 6-Benzofurancarboxylic acid CAS No.:77095-51-3

Cas:77095-51-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

6-Benzofurancarboxylic acid

Cas:77095-51-3

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

6-Benzofurancarboxylic acid

Cas:77095-51-3

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

1-Benzofuran-6-carboxylic acid

Cas:77095-51-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

benzofuran-6-carboxylic acid Basic information Product Name: benzofuran-6-carboxylic acid Synonyms: benzofuran-6-carboxylic acid;6-Benzofurancarboxylic acid;1-benzo

benzofuran-6-carboxylic acid

Cas:77095-51-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 77095-51-3 with competitive price

Cas:77095-51-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d

1-Benzofuran-6-carboxylic acid

Cas:77095-51-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

inquiry

Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

China Biggest Factory Manufacturer Supply benzofuran-6-carboxylic acid CAS 77095-51-3

Cas:77095-51-3

Min.Order:100 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

benzofuran-6-carboxylic acid CAS:77095-51-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality org

benzofuran-6-carboxylic acid CAS:77095-51-3

Cas:77095-51-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

6-Benzofurancarboxylicacid

Cas:77095-51-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price

USP standard purity 99% 1-benzofuran-6-carboxylic acid CAS NO.77095-51-3

Cas:77095-51-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

6-Benzofurancarboxylicacid

Cas:77095-51-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

6-benzofurancarboxylic acid

Cas:77095-51-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

6-BENZOFURANCARBOXYLIC ACID 77095-51-3

Cas:77095-51-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

BENZOFURAN-6-CARBOXYLIC ACID

Cas:77095-51-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

1-benzofuran-6-carboxylic acid

Cas:77095-51-3

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Hope Chem Co., Ltd

1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product

Benzofuran-6-carboxylic acid

Cas:77095-51-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

6-Benzofurancarboxylicacid

Cas:77095-51-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

benzofuran-6-carboxylic acid

Cas:77095-51-3

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

benzofuran-6-carboxylic acid/High quality/Best price

Cas:77095-51-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

1-Benzofuran-6-carboxylic acid

Cas:77095-51-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Senova Pharma

Multi-target purpose intermediate with wide usage Commercial production from grams to tons, with technical documents package support, and audit and inspection support. With high purity and optimized and stable process. Appearance:white s

Lifitegrast KSM/ intermediate

Cas:77095-51-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Siwei Development Group Ltd.

Product name: 6-Benzofurancarboxylic Acid CAS No.:77095-51-3 Molecule Formula:C9H6O3 Molecule Weight:162.14 Purity: 99.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Standard TESTING

High Quality 6-Benzofurancarboxylic Acid on stock

Cas:77095-51-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

benzofuran-6-carboxylic acid

Cas:77095-51-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

benzofuran-6-carboxylicacid

Cas:77095-51-3

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: benzofuran-6-carboxylic acid Synonyms: Lifitegrast Intermediate 1;Benzofuran-6-Caboxylic Acid;benzofuran-6-carboxylic acid;6-Benzofurancarboxylic acid;1-benzofuran-6-carboxylic acid;Lifitegrast Impurity 29 CAS: 77095-51-3 MF:

benzofuran-6-carboxylic acid

Cas:77095-51-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

USP standard purity 99% 1-benzofuran-6-carboxylic acid CAS NO.77095-51-3

Cas:77095-51-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Synthetic route

methyl benzofuran-6-carboxylate
588703-29-1

methyl benzofuran-6-carboxylate

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
With lithium hydroxide; water In tetrahydrofuran at 20℃; for 1h;100%
Stage #1: methyl benzofuran-6-carboxylate With lithium hydroxide In methanol; water at 20℃;
Stage #2: With hydrogenchloride In water
97%
With water; lithium hydroxide In methanol97%
ethyl benzofuran-6-carboxylate
1289646-90-7

ethyl benzofuran-6-carboxylate

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; methanol97%
methyl 3-hydroxy-4-[(trimethylsilyl)ethynyl]benzoate
478169-68-5

methyl 3-hydroxy-4-[(trimethylsilyl)ethynyl]benzoate

methanol
67-56-1

methanol

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
Stage #1: methyl 3-hydroxy-4-[(trimethylsilyl)ethynyl]benzoate With copper(l) iodide; triethylamine In ethanol at 75℃; for 3h;
Stage #2: methanol With pyrographite In ethanol for 1h; Heating / reflux;
Stage #3: With sodium hydroxide In ethanol at 20℃;
93%
C12H14O3Si

C12H14O3Si

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
With copper(l) iodide; triethylamine In ethanol at 75 - 85℃; for 3h;92%
benzo[b]furan-6-carbonitrile
17450-68-9

benzo[b]furan-6-carbonitrile

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
With water; sodium hydroxide at 90℃;85%
benzofuran-6-carboxaldehyde
123297-88-1

benzofuran-6-carboxaldehyde

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
With dihydrogen peroxide; sodium hydroxide In water at 75 - 90℃;70%
carbon dioxide
124-38-9

carbon dioxide

6-bromo-benzofuran
128851-73-0

6-bromo-benzofuran

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
Stage #1: 6-bromo-benzofuran With magnesium; ethylene dibromide In tetrahydrofuran at 70℃; for 2h;
Stage #2: carbon dioxide In tetrahydrofuran at -40℃;
24%
methyl 3-hydroxy-4-[(trimethylsilyl)ethynyl]benzoate
478169-68-5

methyl 3-hydroxy-4-[(trimethylsilyl)ethynyl]benzoate

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: CuI; Et3N / ethanol / 3 h / 75 °C
1.2: DARCO / ethanol; methanol / 1 h / Heating
2.1: aq. NaOH / 20 °C
View Scheme
methyl 3-hydroxy-4-iodobenzoate
157942-12-6

methyl 3-hydroxy-4-iodobenzoate

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 91 percent / Pd(PPh3)2Cl2; CuI; Et3N / tetrahydrofuran; CHCl3 / 4 h / 50 °C
2.1: CuI; Et3N / ethanol / 3 h / 75 °C
2.2: DARCO / ethanol; methanol / 1 h / Heating
3.1: aq. NaOH / 20 °C
View Scheme
3-hydroxy-4-(2-propenyl)benzoic acid
103204-81-5

3-hydroxy-4-(2-propenyl)benzoic acid

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: SOCl2, DMF / 3 h
2: 0.5 h
3: 1.) O3, 2.) (CH3)2S / 1.) MeOH, -70 deg C, 15 min, 2.) MeOH, RT, overnight
4: 85percent H3PO4 / 100 °C
5: 87 percent / 35percent aq. KOH / methanol / 100 °C
View Scheme
methyl 3-(prop-2-enyloxy)benzoate
79250-46-7

methyl 3-(prop-2-enyloxy)benzoate

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 27 percent / 1 h / 230 °C
2: SOCl2, DMF / 3 h
3: 0.5 h
4: 1.) O3, 2.) (CH3)2S / 1.) MeOH, -70 deg C, 15 min, 2.) MeOH, RT, overnight
5: 85percent H3PO4 / 100 °C
6: 87 percent / 35percent aq. KOH / methanol / 100 °C
View Scheme
methyl 3-hydroxy-4-(2-propenyl)benzoate
79950-41-7

methyl 3-hydroxy-4-(2-propenyl)benzoate

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) O3, 2.) (CH3)2S / 1.) MeOH, -70 deg C, 15 min, 2.) MeOH, RT, overnight
2: 85percent H3PO4 / 100 °C
3: 87 percent / 35percent aq. KOH / methanol / 100 °C
View Scheme
4-Allyl-3-hydroxy-benzoyl chloride

4-Allyl-3-hydroxy-benzoyl chloride

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 0.5 h
2: 1.) O3, 2.) (CH3)2S / 1.) MeOH, -70 deg C, 15 min, 2.) MeOH, RT, overnight
3: 85percent H3PO4 / 100 °C
4: 87 percent / 35percent aq. KOH / methanol / 100 °C
View Scheme
methyl 2-hydroxy-2,3-dihydrobenzofuran-6-carboxylate
166599-86-6

methyl 2-hydroxy-2,3-dihydrobenzofuran-6-carboxylate

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 85percent H3PO4 / 100 °C
2: 87 percent / 35percent aq. KOH / methanol / 100 °C
View Scheme
methyl 4-formyl-3-hydroxybenzoate
24589-98-8

methyl 4-formyl-3-hydroxybenzoate

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

methyl 3-hydroxy-4-[(trimethylsilyl)ethynyl]benzoate
478169-68-5

methyl 3-hydroxy-4-[(trimethylsilyl)ethynyl]benzoate

A

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

B

N-[(1S,2R,4R)-7-Azabicyclo[2.2.1]hept-2-yl]-1-benzofuran-6-carboxamide hydrochloride
501892-53-1

N-[(1S,2R,4R)-7-Azabicyclo[2.2.1]hept-2-yl]-1-benzofuran-6-carboxamide hydrochloride

Conditions
ConditionsYield
With sodium hydroxide; copper(I) iodide In methanol; ethanol; water; triethylamineA n/a
B 1.83 g (93%)
6-hydroxybenzofuran
13196-11-7

6-hydroxybenzofuran

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dichloromethane / 72 h / 20 °C
2: 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 6 h / 70 °C / 6000.6 Torr
3: lithium hydroxide / methanol; water / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: dichloromethane / 72 h
2: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 6 h / 70 °C / 6000.6 Torr / Autoclave
3: lithium hydroxide; water / methanol
View Scheme
6-hydroxybenzofuran-3-one
6272-26-0

6-hydroxybenzofuran-3-one

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine / acetone / 20 °C
2.1: sodium tetrahydroborate / methanol / 20 °C
2.2: 2 h / 20 °C
2.3: 20 °C / Darkness; Inert atmosphere
3.1: dichloromethane / 72 h / 20 °C
4.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 6 h / 70 °C / 6000.6 Torr
5.1: lithium hydroxide / methanol; water / 20 °C
View Scheme
Multi-step reaction with 6 steps
1: triethylamine / acetone
2: sodium tetrahydroborate / methanol / 20 °C
3: hydrogenchloride; water / tetrahydrofuran / 28 °C / Inert atmosphere; Darkness
4: dichloromethane / 72 h
5: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 6 h / 70 °C / 6000.6 Torr / Autoclave
6: lithium hydroxide; water / methanol
View Scheme
trifluoromethanesulfonic acid benzofuran-6-yl ester
227752-25-2

trifluoromethanesulfonic acid benzofuran-6-yl ester

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 6 h / 70 °C / 6000.6 Torr
2: lithium hydroxide / methanol; water / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 6 h / 70 °C / 6000.6 Torr / Autoclave
2: lithium hydroxide; water / methanol
View Scheme
6-(tert-butyl-dimethylsilanyloxy)-[2H]-benzofuran-3-one
299912-77-9

6-(tert-butyl-dimethylsilanyloxy)-[2H]-benzofuran-3-one

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium tetrahydroborate / methanol / 20 °C
1.2: 2 h / 20 °C
1.3: 20 °C / Darkness; Inert atmosphere
2.1: dichloromethane / 72 h / 20 °C
3.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 6 h / 70 °C / 6000.6 Torr
4.1: lithium hydroxide / methanol; water / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: sodium tetrahydroborate / methanol / 20 °C
2: hydrogenchloride; water / tetrahydrofuran / 28 °C / Inert atmosphere; Darkness
3: dichloromethane / 72 h
4: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 6 h / 70 °C / 6000.6 Torr / Autoclave
5: lithium hydroxide; water / methanol
View Scheme
(1-benzofuran-6-yloxy)(tert-butyl)dimethylsilane

(1-benzofuran-6-yloxy)(tert-butyl)dimethylsilane

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogenchloride; water / tetrahydrofuran / 28 °C / Inert atmosphere; Darkness
2: dichloromethane / 72 h
3: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 6 h / 70 °C / 6000.6 Torr / Autoclave
4: lithium hydroxide; water / methanol
View Scheme
6-bromo-benzofuran
128851-73-0

6-bromo-benzofuran

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: isopropylmagnesium bromide / tetrahydrofuran / 0.5 h / -25 °C
1.2: -25 °C
2.1: sodium hydroxide; dihydrogen peroxide / water / 75 - 90 °C
View Scheme
Multi-step reaction with 2 steps
1: tetrahydrofuran / Reflux
2: sodium hydroxide; water / 90 °C
View Scheme
3-Carboxyphenol
99-06-9

3-Carboxyphenol

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: methanesulfonic acid / 3 h / 80 °C / Large scale
2: thionyl chloride / 3 h / 60 °C / Large scale
3: potassium tert-butylate / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere; Large scale
4: sodium hydroxide / methanol; water / 1 h / 20 - 35 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1: sodium hydroxide; sodium hypochlorite / methanol / 72 h / 0 - 30 °C
2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran; chloroform / 4 h / 50 - 60 °C / Inert atmosphere
3: copper(l) iodide; triethylamine / ethanol / 3 h / 75 - 85 °C
View Scheme
4-formyl-3-hydroxybenzoic acid
619-12-5

4-formyl-3-hydroxybenzoic acid

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: thionyl chloride / 3 h / 60 °C / Large scale
2: potassium tert-butylate / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere; Large scale
3: sodium hydroxide / methanol; water / 1 h / 20 - 35 °C / Large scale
View Scheme
3-hydroxy-4-iodobenzoic acid
58123-77-6

3-hydroxy-4-iodobenzoic acid

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran; chloroform / 4 h / 50 - 60 °C / Inert atmosphere
2: copper(l) iodide; triethylamine / ethanol / 3 h / 75 - 85 °C
View Scheme
benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

benzofuran-6-carboxylic chloride

benzofuran-6-carboxylic chloride

Conditions
ConditionsYield
With thionyl chloride; N,N-dimethyl-formamide In toluene Inert atmosphere; Heating;100%
With thionyl chloride In benzene for 3h; Heating;
With methanesulfonyl chloride; triethylamine
benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

C10H9Cl2NO2*C2HF3O2

C10H9Cl2NO2*C2HF3O2

2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3 ,4-tetrahydroisoquinoline-6-carboxylic acid

2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3 ,4-tetrahydroisoquinoline-6-carboxylic acid

Conditions
ConditionsYield
Stage #1: benzofuran-6-carboxylic acid With N-ethyl-N,N-diisopropylamine; HATU In tetrahydrofuran at 20 - 30℃; for 2h; Inert atmosphere;
Stage #2: C10H9Cl2NO2*C2HF3O2 In tetrahydrofuran at 20 - 30℃;
98%
methanol
67-56-1

methanol

benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

methyl benzofuran-6-carboxylate
588703-29-1

methyl benzofuran-6-carboxylate

Conditions
ConditionsYield
With sulfuric acid at 20℃;96%
benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

(S)-2-(8-chloro-2,3-dihydro-1H-pyrrole[3,2,1-ij]isoquinazolin-7-carbonylamino)-3-(3-(methanesulfonyl)phenyl)propanoic acid benzyl ester trifluoroacetate salt

(S)-2-(8-chloro-2,3-dihydro-1H-pyrrole[3,2,1-ij]isoquinazolin-7-carbonylamino)-3-(3-(methanesulfonyl)phenyl)propanoic acid benzyl ester trifluoroacetate salt

(S)-2-(8-chloro-2-(benzofuran-6-carbonyl)-2,3-dihydro-1H-pyrrole[3,2,1-ij]quinazolin-7-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid benzyl ester

(S)-2-(8-chloro-2-(benzofuran-6-carbonyl)-2,3-dihydro-1H-pyrrole[3,2,1-ij]quinazolin-7-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid benzyl ester

Conditions
ConditionsYield
Stage #1: benzofuran-6-carboxylic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: (S)-2-(8-chloro-2,3-dihydro-1H-pyrrole[3,2,1-ij]isoquinazolin-7-carbonylamino)-3-(3-(methanesulfonyl)phenyl)propanoic acid benzyl ester trifluoroacetate salt In N,N-dimethyl-formamide at 20℃; for 12h;
95%
benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

dichloro quinoline ester
851784-90-2

dichloro quinoline ester

C20H15Cl2NO4
851784-92-4

C20H15Cl2NO4

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dmap In DMF (N,N-dimethyl-formamide) at 20℃; for 15h;92%
Stage #1: benzofuran-6-carboxylic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In tetrahydrofuran at 25 - 35℃; for 0.5h;
Stage #2: dichloro quinoline ester In tetrahydrofuran at 25 - 35℃; for 3h;
benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

4-(4-methoxybenzyl)-6-piperidin-4-ylpyrimidin-2-amine
198554-72-2

4-(4-methoxybenzyl)-6-piperidin-4-ylpyrimidin-2-amine

4-[1-(1-benzofuran-6-ylcarbonyl)piperidin-4-yl]-6-(4-methoxybenzyl)pyrimidin-2-amine
198554-13-1

4-[1-(1-benzofuran-6-ylcarbonyl)piperidin-4-yl]-6-(4-methoxybenzyl)pyrimidin-2-amine

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In chloroform at 20℃;88%
benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3 ,4-tetrahydroisoquinoline-6-carboxylic acid

2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3 ,4-tetrahydroisoquinoline-6-carboxylic acid

Conditions
ConditionsYield
Stage #1: benzofuran-6-carboxylic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 0℃; for 3h; Inert atmosphere;
Stage #2: 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid In dichloromethane at 30℃; for 8h; Reagent/catalyst; Temperature; Solvent;
87.01%
benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

(S)-2-(5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid
851785-70-1

(S)-2-(5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid
1025967-78-5

(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -10 - 20℃; Reagent/catalyst; Solvent; Temperature;83.8%
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 10 - 20℃; for 1.5h;
benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

(S)-2-(5-(7-dichloro-1,2,3,4-tetrahydroisoquinolin-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid) hydrochloride

(S)-2-(5-(7-dichloro-1,2,3,4-tetrahydroisoquinolin-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid) hydrochloride

N-cyclohexyl-cyclohexanamine
101-83-7

N-cyclohexyl-cyclohexanamine

lifitegrast dicyclohexylamine salt

lifitegrast dicyclohexylamine salt

Conditions
ConditionsYield
Stage #1: benzofuran-6-carboxylic acid; (S)-2-(5-(7-dichloro-1,2,3,4-tetrahydroisoquinolin-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid) hydrochloride In dichloromethane; dimethyl sulfoxide at 0 - 5℃; for 2h;
Stage #2: N-cyclohexyl-cyclohexanamine In water at 0 - 25℃; for 41h; pH=8.3; Temperature;
65%
benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

6a-naltrexamine hydrochloride
67025-97-2, 84774-95-8

6a-naltrexamine hydrochloride

17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(benzofuran-6-carboxamido)morphinan

17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(benzofuran-6-carboxamido)morphinan

Conditions
ConditionsYield
Stage #1: benzofuran-6-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide for 1h; Molecular sieve; Cooling with ice; Inert atmosphere;
Stage #2: 6a-naltrexamine hydrochloride In N,N-dimethyl-formamide at 20℃; Inert atmosphere;
Stage #3: With potassium carbonate In methanol at 20℃; Inert atmosphere;
62%
benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

20'-aminovinblastine

20'-aminovinblastine

C55H63N5O10

C55H63N5O10

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 23℃; for 12h; Inert atmosphere;54%
benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

C19H19Cl2N3O4S
851784-86-6

C19H19Cl2N3O4S

C28H23Cl2N3O6S

C28H23Cl2N3O6S

Conditions
ConditionsYield
Stage #1: benzofuran-6-carboxylic acid With N-ethyl-N,N-diisopropylamine; HATU In DMF (N,N-dimethyl-formamide) at 20℃; for 0.5h;
Stage #2: C19H19Cl2N3O4S In DMF (N,N-dimethyl-formamide) at 45℃; for 12h;
50%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 45℃;
benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

6β-naltrexamine
67025-97-2

6β-naltrexamine

17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(benzofuran-6-carboxamido)morphinan

17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(benzofuran-6-carboxamido)morphinan

Conditions
ConditionsYield
Stage #1: benzofuran-6-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide for 1h; Molecular sieve; Cooling with ice; Inert atmosphere;
Stage #2: 6β-naltrexamine In N,N-dimethyl-formamide at 20℃; Inert atmosphere;
Stage #3: With potassium carbonate In methanol at 20℃; Inert atmosphere;
44%
benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-6-carboxamide

N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-6-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 18h;
With N-ethyl-N,N-diisopropylamine; HATU In DMF (N,N-dimethyl-formamide) at 0℃; for 18h;
benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

6-(4,4-dimethyl-2-oxazolin-2-yl)benzofuran

6-(4,4-dimethyl-2-oxazolin-2-yl)benzofuran

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: thionyl chloride / benzene / 3 h / Heating
2: CH2Cl2 / 3 h / Ambient temperature
3: thionyl chloride / 12 h / Ambient temperature
View Scheme
benzofuran-6-carboxylic acid
77095-51-3

benzofuran-6-carboxylic acid

benzofuran-6-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide

benzofuran-6-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride / benzene / 3 h / Heating
2: CH2Cl2 / 3 h / Ambient temperature
View Scheme

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