hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:78755-80-3
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Trading Company
inquiry7-Fluoro-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dione CAS:78755-80-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates,
Cas:78755-80-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:78755-80-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:78755-80-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Cas:78755-80-3
Min.Order:0
Negotiable
Type:Manufacturers
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:78755-80-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:78755-80-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:78755-80-3
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
Cas:78755-80-3
Min.Order:0
Negotiable
Type:Trading Company
inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
Cas:78755-80-3
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Lab/Research institutions
inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
Cas:78755-80-3
Min.Order:0
Negotiable
Type:Other
inquiry1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.
Cas:78755-80-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquirybest seller Application:API
Cas:78755-80-3
Min.Order:0
Negotiable
Type:Manufacturers
inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
Cas:78755-80-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryWe product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate
Cas:78755-80-3
Min.Order:0
Negotiable
Type:Trading Company
inquiryFactory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China
Cas:78755-80-3
Min.Order:0
Negotiable
Type:Trading Company
inquirybest seller Application:API
Cas:78755-80-3
Min.Order:0
Negotiable
Type:Trading Company
inquiry7-Fluoro-3,4-dihydro-4-methyl-1H-1,4-benzodiazepine-2,5-dioneAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express
Cas:78755-80-3
Min.Order:0
Negotiable
Type:Other
inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
Cas:78755-80-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryGood Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen
Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
Cas:78755-80-3
Min.Order:0
Negotiable
Type:Other
inquirybest seller Application:API
Cas:78755-80-3
Min.Order:0
Negotiable
Type:Trading Company
inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
Cas:78755-80-3
Min.Order:0
Negotiable
Type:Trading Company
inquiryBest Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP
Cas:78755-80-3
Min.Order:0
Negotiable
Type:Trading Company
inquiryOur mission is to provide high-quality and innovative products to our customers. By offering a broad range of products, custom synthesis and personalized services, Bide can help scientists speeding up their research in the chemical and pharmaceutical
Cas:78755-80-3
Min.Order:0
Negotiable
Type:Other
inquiry1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G
Cas:78755-80-3
Min.Order:10 Milligram
Negotiable
Type:Lab/Research institutions
inquiry
Cas:78755-80-3
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryChangzhou Extraordinary Pharmatech co., LTD. As a leading chemical manufacturer and supplier in China.DAS authentication is passed.We can provide the popular precursor chemicals, we have our own strong R & D team, have our own laboratories and fa
Cas:78755-80-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryWatson International Ltd' has a very strong R&D and technical capacity supported by FCAD's platform. The subsidiaries under FCAD Group have accumulated much know-how of different fine chemical branches. For example, Apnoke Scientific L
Cas:78755-80-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry5-fluoroisatoic anhydride
sarcosine
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
Conditions | Yield |
---|---|
With pyridine at 5℃; for 7h; Reflux; | 76% |
In dimethyl sulfoxide at 157℃; for 2h; | |
With pyridine at 100℃; for 8h; | 5.34 g |
2-amino-5-fluorobenzoic acid
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1,4-dioxane / 1 h / Cooling; Reflux 2: dimethyl sulfoxide / 2 h / 157 °C View Scheme |
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one
Conditions | Yield |
---|---|
With Dimethyl-p-toluidine; trichlorophosphate In toluene at 100℃; for 2h; | 86% |
With N,N-dimethyl-aniline; trichlorophosphate In acetonitrile at 80 - 90℃; for 3h; Large scale; |
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
7-fluoro-4-methyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In 1,4-dioxane at 0 - 20℃; for 4h; Inert atmosphere; | 62% |
Ethyl isocyanoacetate
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
flumazenil
Conditions | Yield |
---|---|
Multistep reaction; |
3-(isocyanomethyl)-5-methyl-1,2,4-oxadiazole
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
Conditions | Yield |
---|---|
Yield given. Multistep reaction; |
5-Ethyl-3-isocyanomethyl-1,2,4-oxadiazole
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
Conditions | Yield |
---|---|
Yield given. Multistep reaction; |
3-(isocyanomethyl)-5-isopropyl-1,2,4-oxadiazole
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
Conditions | Yield |
---|---|
Yield given. Multistep reaction; |
3-(isocyanomethyl)-5-n-propyl-1,2,4-oxadiazole
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
Conditions | Yield |
---|---|
Yield given. Multistep reaction; |
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
flumazenil
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 86 percent / phosphorus oxychloride; N,N-dimethyl-p-toluidine / toluene / 2 h / 100 °C 2.1: LHMDS / tetrahydrofuran / 1.5 h / -35 °C 2.2: N,N-dimethyl-p-toluidine / tetrahydrofuran / 3 h / -40 - -35 °C 2.3: 98 percent / acetic acid / tetrahydrofuran / 6 h / pH 5 - 7 / Heating View Scheme | |
Multi-step reaction with 3 steps 1.1: 86 percent / phosphorus oxychloride; N,N-dimethyl-p-toluidine / toluene / 2 h / 100 °C 2.1: LHMDS / tetrahydrofuran / 2 h / -30 °C 2.2: N,N-dimethyl-p-toluidine / tetrahydrofuran / -35 °C / pH 7 3.1: acetic acid / tetrahydrofuran / pH 5 / Heating View Scheme |
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 86 percent / phosphorus oxychloride; N,N-dimethyl-p-toluidine / toluene / 2 h / 100 °C 2: 100 percent / ethanol / 0.5 h View Scheme |
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 86 percent / phosphorus oxychloride; N,N-dimethyl-p-toluidine / toluene / 2 h / 100 °C 2.1: LHMDS / tetrahydrofuran / 2 h / -30 °C 2.2: N,N-dimethyl-p-toluidine / tetrahydrofuran / -35 °C 3.1: 100 percent / acetic acid / tetrahydrofuran / Heating View Scheme | |
Multi-step reaction with 4 steps 1.1: 86 percent / phosphorus oxychloride; N,N-dimethyl-p-toluidine / toluene / 2 h / 100 °C 2.1: LHMDS / tetrahydrofuran / 2 h / -30 °C 2.2: N,N-dimethyl-p-toluidine / tetrahydrofuran / -35 °C 3.1: tetrahydrofuran / 20 °C 4.1: 100 percent / acetic acid / tetrahydrofuran / Heating View Scheme |
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 86 percent / phosphorus oxychloride; N,N-dimethyl-p-toluidine / toluene / 2 h / 100 °C 2: 73 percent / LHMDS / tetrahydrofuran / 16 h / -30 °C View Scheme |
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 86 percent / phosphorus oxychloride; N,N-dimethyl-p-toluidine / toluene / 2 h / 100 °C 2.1: LHMDS / tetrahydrofuran / 2 h / -30 °C 2.2: N,N-dimethyl-p-toluidine / tetrahydrofuran / -35 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: 86 percent / phosphorus oxychloride; N,N-dimethyl-p-toluidine / toluene / 2 h / 100 °C 2.1: LHMDS / tetrahydrofuran / 2 h / -30 °C 2.2: N,N-dimethyl-p-toluidine / tetrahydrofuran / -35 °C 3.1: tetrahydrofuran / 20 °C View Scheme |
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 86 percent / phosphorus oxychloride; N,N-dimethyl-p-toluidine / toluene / 2 h / 100 °C 2.1: LHMDS / tetrahydrofuran / 2 h / -30 °C 2.2: N,N-dimethyl-p-toluidine / tetrahydrofuran / -35 °C View Scheme |
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 86 percent / phosphorus oxychloride; N,N-dimethyl-p-toluidine / toluene / 2 h / 100 °C 2.1: LHMDS / tetrahydrofuran / 2 h / -30 °C 2.2: N,N-dimethyl-p-toluidine / tetrahydrofuran / -35 °C / pH 7 View Scheme |
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 86 percent / phosphorus oxychloride; N,N-dimethyl-p-toluidine / toluene / 2 h / 100 °C 2.1: LHMDS / tetrahydrofuran / 2 h / -30 °C 2.2: N,N-dimethyl-p-toluidine / tetrahydrofuran / -35 °C / pH 7 3.1: acetic acid / tetrahydrofuran / pH 5 / Heating View Scheme |
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 2: 1) NaH, molecular sieves / 1) THF, r.t., 2) THF, reflux View Scheme |
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 2: 1) NaH, molecular sieves / 1) THF, r.t., 2) THF, reflux View Scheme |
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 2: 1) NaH, molecular sieves / 1) THF, r.t., 2) THF, reflux View Scheme |
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 2: 1) NaH, molecular sieves / 1) THF, r.t., 2) THF, reflux View Scheme |
Ethyl isocyanoacetate
potassium tert-butylate
diethyl chlorophosphate
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
flumazenil
Conditions | Yield |
---|---|
In N-methyl-acetamide; water; acetic acid |
dichloroamine
Ethyl isocyanoacetate
potassium tert-butylate
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
flumazenil
Conditions | Yield |
---|---|
With sodium hydrogencarbonate; acetic acid; trichlorophosphate In N-methyl-acetamide; chloroform; water; 2,3-Dimethylaniline |
diethyl chlorophosphate
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
Conditions | Yield |
---|---|
Stage #1: 7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.333333h; Inert atmosphere; Stage #2: diethyl chlorophosphate In tetrahydrofuran at -35 - 0℃; Inert atmosphere; |
tert-Butyl isocyanoacetate
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
Conditions | Yield |
---|---|
With sodium hydride; diethyl chlorophosphate In tetrahydrofuran; N,N-dimethyl-formamide |
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
methyl (2E)-3-(7-fluoro-4-methyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-1-yl)acrylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / 1,4-dioxane / 4 h / 0 - 20 °C / Inert atmosphere 2: methanol / 1 h / 20 °C View Scheme |
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / 1,4-dioxane / 4 h / 0 - 20 °C / Inert atmosphere 2: methanol / 1 h / 20 °C View Scheme |
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
1-acetyl-7-fluoro-4-methyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / 1,4-dioxane / 4 h / 0 - 20 °C / Inert atmosphere 2: acetonitrile / 1 h / 20 °C / Reflux View Scheme |
7-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione
methyl (2E)-3-(1-acetyl-7-fluoro-1,2,3,5-tetrahydro-4H-1,4-benzodiazepin-4-yl)acrylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: lithium aluminium tetrahydride / 1,4-dioxane / 4 h / 0 - 20 °C / Inert atmosphere 2: acetonitrile / 1 h / 20 °C / Reflux 3: acetonitrile / 120 h / Reflux View Scheme |
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